Marcia L Feijoo-Coronel, Bruno Mendes, David Ramírez, Carlos Peña-Varas, Nina Q E de Los Monteros-Silva, Carolina Proaño-Bolaños, Leonardo Camilo de Oliveira, Diego Fernandes Lívio, José Antônio da Silva, José Maurício S F da Silva, Marília Gabriella A G Pereira, Marina Q R B Rodrigues, Mauro M Teixeira, Paulo Afonso Granjeiro, Ketan Patel, Sakthivel Vaiyapuri, José R Almeida
Antimicrobial peptides have been developed based on plant-derived molecular scaffolds for the treatment of infectious diseases. Chenopodin is an abundant seed storage protein in quinoa, an Andean plant with high nutritional and therapeutic properties. Here, we used computer- and physicochemical-based strategies and designed four peptides derived from the primary structure of Chenopodin. Two peptides reproduce natural fragments of 14 amino acids from Chenopodin, named Chen1 and Chen2, and two engineered peptides of the same length were designed based on the Chen1 sequence...
January 14, 2024: Antibiotics