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Paul van de Heyning, Santiago L Arauz, Marcus Atlas, Wolf-Dieter Baumgartner, Marco Caversaccio, Ronel Chester-Browne, Patricia Estienne, Javier Gavilan, Benoit Godey, Wolfgang Gstöttner, Demin Han, Rudolph Hagen, Martin Kompis, Vlad Kuzovkov, Luis Lassaletta, Franc Lefevre, Yongxin Li, Joachim Müller, Lorne Parnes, Andrea Kleine Punte, Christopher Raine, Gunesh Rajan, Adriana Rivas, José Antonio Rivas, Nicola Royle, Georg Sprinzl, Kurt Stephan, Adam Walkowiak, Yuri Yanov, Kim Zimmermann, Patrick Zorowka, Henryk Skarzynski
One of the many parameters that can affect cochlear implant (CI) users' performance is the site of presentation of electrical stimulation, from the CI, to the auditory nerve. Evoked compound action potential (ECAP) measurements are commonly used to verify nerve function by stimulating one electrode contact in the cochlea and recording the resulting action potentials on the other contacts of the electrode array. The present study aimed to determine if the ECAP amplitude differs between the apical, middle, and basal region of the cochlea, if double peak potentials were more likely in the apex than the basal region of the cochlea, and if there were differences in the ECAP threshold and recovery function across the cochlea...
November 30, 2016: Cochlear Implants International
Paweł Mateusz Nowak, Michał Woźniakiewicz, Maciej Michalik, Leszek Fiedor, Paweł Kościelniak
The choice between bare and coated capillaries is a key decision in the development and use of any methods based on capillary electrophoresis. In this work several permanently and dynamically coated capillaries were successfully implemented in a previously developed micellar electrokinetic chromatography (MEKC) assay of the plant membrane enzyme chlorophyllase. The results obtained demonstrate the rationale behind the use of capillary coating, which is crucial for successful optimization of both the off-line mode and the on-line/electrophoretically mediated microanalysis assay mode...
November 25, 2016: Analytical and Bioanalytical Chemistry
S Hoth, I Herisanu, M Praetorius
BACKGROUND: When setting the electrical stimulation level of cochlear implants during individual adjustment of the speech processor, especially in children, objective measures such as intracochlearly measured electrically evoked compound action potentials (eCAP) and intraoperative observation of electrically elicited stapedial reflexes (eSR) are indispensable. The benefit of these objective measures is based on the correlation between the derived response thresholds and psychometric data...
December 2016: HNO
Ruben H M van Eijl, Patrick J Buitenhuis, Inge Stegeman, Sjaak F L Klis, Wilko Grolman
OBJECTIVES/HYPOTHESIS: The variability in speech perception between cochlear implant users is thought to result from the degeneration of the auditory nerve. Degeneration of the auditory nerve, histologically assessed, correlates with electrophysiologically acquired measures, such as electrically evoked compound action potentials (eCAPs) in experimental animals. To predict degeneration of the auditory nerve in humans, where histology is impossible, this paper reviews the correlation between speech perception and eCAP recordings in cochlear implant patients...
November 2, 2016: Laryngoscope
Graziela Aparecida Nogueira de Almeida Ribeiro, Helenice Brizolla Giampietro, Lídia Barbieri Belarmino, Wilson Salgado-Júnior
Background: The psychologist who works in bariatric surgery has a role to receive, evaluate, prepare and educate the patient who will undergo the surgical procedure. Psychological evaluation becomes important in so far as allows us to obtain data on personal and familiar history and allow tracing of possible psychopathology. Aim: To collect data on psychological evaluations of patients in a bariatric surgery service of a public hospital in order to describe the psychological profile of patients in this service...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
Anna Kłak, Filip Raciborski, Edyta Krzych-Fałta, Dagmara Opoczyńska-Świeżewska, Jakub Szymański, Agnieszka Lipiec, Barbara Piekarska, Adam Sybilski, Aneta Tomaszewska, Bolesław Samoliński
INTRODUCTION: The aim of the study is to indicate the relation between the use of alternative medicine and the occurrence of allergic diseases in the Polish population of adults in the age of 20-44 years. Moreover the additional aim of the study is to define the relation between the sex, age and place of living and the use of alternative medicine. MATERIAL AND METHODS: The data from the project Epidemiology of Allergic Diseases in Poland (ECAP) has been used for analysis...
2016: Pneumonologia i Alergologia Polska
Fanny Sunden, Ishraq AlSadhan, Artem Y Lyubimov, Susanne Ressl, Helen Wiersma-Koch, Jamar Borland, Clayton L Brown, Tory A Johnson, Zorawar Singh, Daniel Herschlag
Naively one might have expected an early division between phosphate monoesterases and diesterases of the alkaline phosphatase (AP) superfamily. On the contrary, prior results and our structural and biochemical analyses of phosphate monoesterase PafA, from Chryseobacterium meningosepticum, indicate similarities to a superfamily phosphate diesterase [Xanthomonas citri nucleotide pyrophosphatase/phosphodiesterase (NPP)] and distinct differences from the three metal ion AP superfamily monoesterase, from Escherichia coli AP (EcAP)...
November 2, 2016: Journal of the American Chemical Society
Edyta Krzych-Fałta, Konrad Furmanczyk, Bolesław Samolinski, Barbara Piekarska, Piotr Samel-Kowalik, Agnieszka Lipiec, Filip Raciborski, Adam Sybilski
OBJECTIVE: The aim of this study was to estimate the reference values for nasal inspiratory flow in the study population in Poland as part of the project on Epidemiology of Allergic Diseases in Poland (ECAP). MATERIALS AND METHOD: The study subjects were a group of 4,137 people: 1,136 children aged 6-7 years (561 girls and 575 boys), 1,123 adolescents aged 13-14 years (546 girls, 577 boys) and 1,878 adults (1,145 women, 733 men), residing in seven large Polish cities...
September 2016: Annals of Agricultural and Environmental Medicine: AAEM
S Redana, A Sharp, H Lote, K Mohammed, E Papadimitraki, M Capelan, A Ring
OBJECTIVES: To determine the incidence and risk factors for thromboembolic events (TE) and febrile neutropenia (FN) in patients receiving systemic chemotherapy for early breast cancer (EBC). METHODS: 325 patients received FEC75, FEC100-T or ECaP for EBC in 2013. RESULTS: TE occurred in 7.4% and FN in 19.1% of patients. Risk factors for TE were: central venous catheter (p = 0.011). Risk factors for FN were: FEC100-T treatment versus FEC75 and ECaP (p ≤ 0...
December 2016: Breast: Official Journal of the European Society of Mastology
Xin Luo, Ching-Chih Wu
In cochlear implants (CIs), standard partial tripolar (pTP) mode reduces current spread by returning a fraction of the current to two adjacent flanking electrodes within the cochlea. Symmetric electrode spanning (i.e., separating both the apical and basal return electrodes from the main electrode by one electrode) has been shown to increase the pitch of pTP stimuli, when the ratio of intracochlear return current was fixed. To explain the pitch increase caused by symmetric spanning in pTP mode, this study measured the electrical potentials of both standard and symmetrically spanned pTP stimuli on a main electrode EL8 in five CI ears using electrical field imaging (EFI)...
December 2016: Journal of the Association for Research in Otolaryngology: JARO
Junyi Zhang, Zhixin Kang, Fen Wang
A Mg-Gd-Nd-Zn-Zr alloy was processed by equal channel angular pressing (ECAP) at 375°C. The grain size of Mg-Gd-Nd-Zn-Zr alloy was refined to ~2.5μm with the spherical precipitates (β1 phase) distributing in the matrix. The mechanical properties of ECAPed alloy were significantly improved as a result of the grain refinement and precipitation strengthening. The corrosion rate of the ECAPed magnesium alloy in simulated body fluid dramatically decreased from 0.236mm/a to 0.126mm/a due to the strong basal texture and refined microstructure...
November 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Kara C Schvartz-Leyzac, Bryan E Pfingst
Electrically evoked compound action potential (ECAP) measures of peak amplitude, and amplitude-growth function (AGF) slope have been shown to reflect characteristics of cochlear health (primarily spiral ganglion density) in anesthetized cochlear-implanted guinea pigs. Likewise, the effect of increasing the interphase gap (IPG) in each of these measures also reflects SGN density in the implanted guinea pig. Based on these findings, we hypothesize that suprathreshold ECAP measures, and also how they change as the IPG is increased, have the potential to be clinically applicable in human subjects...
November 2016: Hearing Research
Lachlan J Kelsey, Janet T Powell, Paul E Norman, Karol Miller, Barry J Doyle
Aneurysms of the common iliac artery (CIAA) are most commonly seen in association with an abdominal aortic aneurysm (AAA). Isolated CIAAs, in the absence of an AAA, are uncommon. Similar to AAAs, CIAA may develop intraluminal thrombus (ILT). As isolated CIAAs have a contralateral common iliac artery for comparison, they provide an opportunity to study the haemodynamic mechanisms behind ILT formation. In this study, we compared a large isolated CIAA and the contralateral iliac artery using computational fluid dynamics (CFD) to determine if haemodynamic metrics correlate with the location of ILT...
August 10, 2016: International Journal for Numerical Methods in Biomedical Engineering
Jeffrey A Melvin, Lauren P Lashua, Megan R Kiedrowski, Guanyi Yang, Berthony Deslouches, Ronald C Montelaro, Jennifer M Bomberger
Antimicrobial-resistant infections are an urgent public health threat, and development of novel antimicrobial therapies has been painstakingly slow. Polymicrobial infections are increasingly recognized as a significant source of severe disease and also contribute to reduced susceptibility to antimicrobials. Chronic infections also are characterized by their ability to resist clearance, which is commonly linked to the development of biofilms that are notorious for antimicrobial resistance. The use of engineered cationic antimicrobial peptides (eCAPs) is attractive due to the slow development of resistance to these fast-acting antimicrobials and their ability to kill multidrug-resistant clinical isolates, key elements for the success of novel antimicrobial agents...
May 2016: MSphere
Miquel de la Torre Villalobos, Luis Miguel Martin-López, María Isabel Fernández Sanmartín, Elena Pujals Altes, Silvia Gasque Llopis, Santiago Batlle Vila, Victor Pérez-Solá, Patricia Novo Navarro, Isabel Gómez Simón, Cristina Fresno González, Ester Camprodon Rosanas, Antonio Bulbena Vilarrasa
BACKGROUND: Cardiovascular and metabolic monitoring of patients on antipsychotic medication is essential. This becomes more important in those of paediatric age, as they are more vulnerable, and also because prescriptions of this kind of drugs are still increasing. AIM: To evaluate the monitoring of cardiovascular and metabolic risk factors in a group of children and young people on antipsychotic medication. METHOD: A descriptive cross-sectional study was conducted in which a group of 220 patients aged 8-17 years, diagnosed with a mental disorder and on antipsychotic treatment...
June 9, 2016: Revista de Psiquiatrí́a y Salud Mental
F Christov, P Munder, L Berg, H Bagus, S Lang, D Arweiler-Harbeck
INTRODUCTION: Electric compound action potentials (ECAPs) provide information about the nerve's and device's function in and after cochlear implantation. In general, lower ECAP values are expected to generate better results. Aim was an analysis of ECAPs in the course of time as a function of the patient's age and electrode design. PATIENTS AND METHODS: Between 2008 and 2013, 168 patients of eight defined age groups were included into the investigation. NRTs were measured intraoperatively, after 6 and after 12months...
June 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
Alessandro Scorpecci, Alessandra D'Elia, Paolo Malerba, Italo Cantore, Patrizia Consolino, Franco Trabalzini, Gaetano Paludetti, Nicola Quaranta
In uncooperative patients, electrical compound action potential (ECAP) thresholds are reliable in predicting T-levels, but are not in determining the C-level profile. The present study aims to assess if the C-level profile can be predicted by a new objective procedure (C-NRT) which uses the amplitude growth function (AGF) and is based on the assumption that equal ECAP amplitudes elicit equal loudness percepts. This is a correlational study conducted in five tertiary care referral hospitals with 21 post-lingually deaf adult cochlear implant users...
May 30, 2016: European Archives of Oto-rhino-laryngology
Lauren P Lashua, Jeffrey A Melvin, Berthony Deslouches, Joseph M Pilewski, Ronald C Montelaro, Jennifer M Bomberger
OBJECTIVES: Chronic infections with the opportunistic pathogen Pseudomonas aeruginosa are responsible for the majority of the morbidity and mortality in patients with cystic fibrosis (CF). While P. aeruginosa infections may initially be treated successfully with standard antibiotics, chronic infections typically arise as bacteria transition to a biofilm mode of growth and acquire remarkable antimicrobial resistance. To address the critical need for novel antimicrobial therapeutics that can effectively suppress chronic bacterial infections in challenging physiological environments, such as the CF lung, we have rationally designed a de novo engineered cationic antimicrobial peptide, the 24-residue WLBU2, with broad-spectrum antibacterial activity for pan-drug-resistant P...
August 2016: Journal of Antimicrobial Chemotherapy
Harkamaljot Kandail, Mohamad Hamady, Xiao Yun Xu
PURPOSE: To quantify the hemodynamic impact of a flared renal stent on the performance of fenestrated stent-grafts (FSGs) by analyzing flow patterns and wall shear stress-derived parameters in flared and nonflared FSGs in different physiologic scenarios. METHODS: Hypothetical models of FSGs were created with and without flaring of the proximal portion of the renal stent. Flared FSGs with different dilation angles and protrusion lengths were examined, as well as a nonplanar flared FSG to account for lumbar curvature...
October 2016: Journal of Endovascular Therapy
Agnieszka Witecka, Aleksandra Bogucka, Akiko Yamamoto, Kristián Máthis, Tomáš Krajňák, Jakub Jaroszewicz, Wojciech Święszkowski
In vitro degradation behavior of squeeze cast (CAST) and equal channel angular pressed (ECAP) ZM21 magnesium alloy (2.0wt% Zn-0.98wt% Mn) was studied using immersion tests up to 4w in three different biological environments. Hanks' Balanced Salt Solution (Hanks), Earle's Balanced Salt Solution (Earle) and Eagle minimum essential medium supplemented with 10% (v/v) fetal bovine serum (E-MEM+10% FBS) were used to investigate the effect of carbonate buffer system, organic compounds and material processing on the degradation behavior of the ZM21 alloy samples...
August 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
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