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https://www.readbyqxmd.com/read/28693819/haemodynamics-and-stresses-in-abdominal-aortic-aneurysms-a-fluid-structure-interaction-study-into-the-effect-of-proximal-neck-and-iliac-bifurcation-angle
#1
Corey J Drewe, Louis P Parker, Lachlan J Kelsey, Paul E Norman, Janet T Powell, Barry J Doyle
Our knowledge of how geometry influences abdominal aortic aneurysm (AAA) biomechanics is still developing. Both iliac bifurcation angle and proximal neck angle could impact the haemodynamics and stresses within AAA. Recent comparisons of the morphology of ruptured and intact AAA show that cases with large iliac bifurcation angles are less likely to rupture than those with smaller angles. We aimed to perform fluid-structure interaction (FSI) simulations on a range of idealised AAA geometries to conclusively determine the influence of proximal neck and iliac bifurcation angle on AAA wall stress and haemodynamics...
June 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28691403/effects-of-davallia-formosana-hayata-water-and-alcohol-extracts-on-osteoblastic-mc3t3-e1-cells
#2
Chia-Feng Wu, Yeong-Shenn Lin, Sheng-Chi Lee, Cheng-Yu Chen, Ming-Chang Wu, Jen-Shinn Lin
The Taiwanese native fern Davallia formosana Hayata (DFH) is used to treat bone diseases in classical Chinese medicine. We analyzed MC3T3E1 osteoblasts treated with different concentrations of water and ethanol extracts (10, 25, and 50 [both], and 100 μg/mL [DFE only]) using cell viability, expression of osteoblast differentiation markers [bone morphogenetic protein 2 (BMP-2), collagen 1 (CoL-1), alkaline phosphatase (ALP), and Runt-related transcription factor 2 (Runx 2)], and mineralization. These were significantly increased by DFW or DFE after 24-h incubation compared with the untreated controls...
July 10, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28690494/the-electrically-evoked-compound-action-potential-from-laboratory-to-clinic
#3
REVIEW
Shuman He, Holly F B Teagle, Craig A Buchman
The electrically evoked compound action potential (eCAP) represents the synchronous firing of a population of electrically stimulated auditory nerve fibers. It can be directly recorded on a surgically exposed nerve trunk in animals or from an intra-cochlear electrode of a cochlear implant. In the past two decades, the eCAP has been widely recorded in both animals and clinical patient populations using different testing paradigms. This paper provides an overview of recording methodologies and response characteristics of the eCAP, as well as its potential applications in research and clinical situations...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28688564/utility-of-intraoperative-and-postoperative-radiographs-in-pediatric-cochlear-implant-surgery
#4
Samantha Anne, Jose Miguel Juarez, Amber Shaffer, David Eleff, Dennis Kitsko, Sarah Sydlowski, Erika Woodson, David Chi
OBJECTIVE: Routine plain film radiographs are often obtained to confirm proper placement of electrode after pediatric cochlear implant surgery. Objective is to evaluate necessity of routine radiographs in pediatric cochlear implant cases. STUDY DESIGN: Retrospective review. SETTING: Two tertiary care academic centers. SUBJECTS AND METHODS: Review of all children that underwent cochlear implantation from January 2003 thru June 2015...
August 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28678078/responsiveness-of-the-electrically-stimulated-cochlear-nerve-in-children-with-cochlear-nerve-deficiency
#5
Shuman He, Bahar S Shahsavarani, Tyler C McFayden, Haibo Wang, Katherine E Gill, Lei Xu, Xiuhua Chao, Jianfen Luo, Ruijie Wang, Nancy He
OBJECTIVES: This study aimed to (1) investigate the responsiveness of the cochlear nerve (CN) to a single biphasic-electrical pulse in implanted children with cochlear nerve deficiency (CND) and (2) compare their results with those measured in implanted children with normal-size CNs. DESIGN: Participants included 23 children with CND (CND1 to CND23) and 18 children with normal-size CNs (S1 to S18). All subjects except for CND1 used Cochlear Nucleus cochlear implants with contour electrode arrays in their test ears...
July 1, 2017: Ear and Hearing
https://www.readbyqxmd.com/read/28633960/effect-of-stimulus-level-on-the-temporal-response-properties-of-the-auditory-nerve-in-cochlear-implants
#6
Michelle L Hughes, Sarah A Laurello
Electrically evoked compound action potentials (ECAPs) have been used to examine temporal response patterns of the auditory nerve in cochlear implant (CI) recipients. ECAP responses to individual pulses in a pulse train vary across stimulation rates for individual CI users. For very slow rates, auditory neurons have ample time to discharge, recover, and respond to each pulse in the train. As the pulse rate increases, an alternating ECAP-amplitude pattern occurs. As the stimulation rate increases further, the alternating pattern eventually ceases and the overall ECAP amplitudes are diminished, yielding a relatively stochastic state that presumably reflects a combination of adaptation, desynchronization, and facilitation across fibers...
August 2017: Hearing Research
https://www.readbyqxmd.com/read/28628862/characterization-and-inhibition-studies-of-tissue-nonspecific-alkaline-phosphatase-by-aminoalkanol-derivatives-of-1-7-dimethyl-8-9-diphenyl-4-azatricyclo-5-2-1-0-2-6-dec-8-ene-3-5-10-trione-new-competitive-and-non-competitive-inhibitors-by-capillary-electrophoresis
#7
Błażej Grodner, Mariola Napiórkowska
The article describes the inhibitory effect of two new aminoalkanol derivatives on the enzymatic kinetic of tissue non-specific alkaline phosphatase with use of capillary zone electrophoresis to evaluate the inhibitory effect. This technique allows to investigate of the enzymatic kinetic by the measure of the amounts of the substrate and product in the presence of compound (I) or (II) in the reaction mixture. The separation process was conducted using an eCAP fused-silica capillary. The detector was set at 200nm...
September 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28607224/evaluation-of-focused-multipolar-stimulation-for-cochlear-implants-a-preclinical-safety-study
#8
Robert K Shepherd, Andrew K Wise, Ya Lang Enke, Paul M Carter, James B Fallon
OBJECTIVE: Cochlear implants (CIs) have a limited number of independent stimulation channels due to the highly conductive nature of the fluid-filled cochlea. Attempts to develop highly focused stimulation to improve speech perception in CI users includes the use of simultaneous stimulation via multiple current sources. Focused multipolar (FMP) stimulation is an example of this approach and has been shown to reduce interaction between stimulating channels. However, compared with conventional biphasic current pulses generated from a single current source, FMP is a complex stimulus that includes extended periods of stimulation before charge recovery is achieved, raising questions on whether chronic stimulation with this strategy is safe...
June 13, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28499354/patient-and-care-characteristics-of-self-referrals-treated-by-the-general-practitioner-cooperative-at-emergency-care-access-points-in-the-netherlands
#9
Martijn Rutten, Fieke Vrielink, Marleen Smits, Paul Giesen
BACKGROUND: In the Netherlands, out-of-hours primary care is provided in general practitioner-cooperatives (GPCs). These are increasingly located on site and in collaboration with emergency departments of hospitals (ED). At such sites, also called emergency-care-access-points (ECAP), the GPC is generally responsible for the triage and treatment of self-referrals who used to attend the ED. To evaluate the effects and safety of this novel organisation, we studied the characteristics and the quality of care given by GPCs to self-referrals at ECAPs...
May 12, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28498269/real-time-intracochlear-electrocochleography-obtained-directly-through-a-cochlear-implant
#10
Michael S Harris, William Jason Riggs, Kanthaiah Koka, Leonid M Litvak, Prashant Malhotra, Aaron C Moberly, Brendan P O'Connell, Jourdan Holder, Federico Alberto Di Lella, Carlos Mario Boccio, George B Wanna, Robert F Labadie, Oliver F Adunka
HYPOTHESIS: Utilizing the cochlear implant to record electrophysiologic responses during device placement is a feasible and efficacious technique for monitoring near real-time cochlear physiology during and following electrode insertion. BACKGROUND: Minimizing intracochlear trauma during cochlear implantation has emerged as a highly researched area to help improve patient performance. Currently, conventional cochlear implant technology allows for the recording of electrically evoked compound action potentials (eCAPs)...
July 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28485290/wp%C3%A5-yw-wybranych-czynnik%C3%A3-w-%C3%A5-rodowiskowych-na-maksymalny-przep%C3%A5-yw-nosowy-wdechowy-cz%C3%A4-%C3%A5-%C3%A4-projektu-ecap-epidemiologia-chor%C3%A3-b-alergicznych-w-polsce
#11
Edyta Krzych-Fałta, Konrad Furmańczyk, Barbara Piekarska, Adam Sybilski, Bolesław Samoliński
Celem niniejszej pracy była próba określenia wpływu wybranych czynników/parametrów na wynik maksymalnego przepływu nosowego wdechowego (PNIF, ang. peak nasal inspiratory flow) w badanej populacji polskiej projektu Epidemiologia Chorób Alergicznych w Polsce (ECAP). Materiał/metody: Badaną populację stanowiła grupa dzieci w wieku 6-7 lat (n=1123), młodzieży w wieku 13-14 lat (n=1136) oraz dorosłych (n=1876) zamieszkałych w siedmiu dużych polskich miastach. W badaniu posłużono się pomiarem maksymalnego przepływu nosowego wdechowego (PNIF)...
February 28, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28469553/intracochlear-recordings-of-acoustically-and-electrically-evoked-potentials-in-nucleus-hybrid-l24-cochlear-implant-users-and-their-relationship-to-speech-perception
#12
Jae-Ryong Kim, Viral D Tejani, Paul J Abbas, Carolyn J Brown
The Hybrid cochlear implant (CI) has been developed for individuals with high frequency hearing loss who retain good low frequency hearing. Outcomes have been encouraging but individual variability is high; the health of the cochlea and the auditory nerve may be important factors driving outcomes. Electrically evoked compound action potentials (ECAPs) reflect the response of the auditory nerve to electrical stimulation while electrocochleography (ECochG) reflects the response of the cochlear hair cells and auditory nerve to acoustic stimulation...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28468652/-epicatechin-3-o-%C3%AE-d-allopyranoside-prevent-ovariectomy-induced-bone-loss-in-mice-by-suppressing-rankl-induced-nf-%C3%AE%C2%BAb-and-nfatc-1-signaling-pathways
#13
Hung-Bo Hsiao, Jin-Bin Wu, Wen-Chuan Lin
BACKGROUND: Davallia formosana Hayata is a herb that has been used in Chinese medicine to treat bone diseases, including arthritis, bone fractures and osteoporosis. The rhizome of D. formosana H. has been found to be rich in (-)-Epicatechin 3-O-β-D-allopyranoside (ECAP), which is considered to be the active component of the plant in terms of its antiosteoporotic effect. This study investigated the molecular mechanism of the antiosteoporotic property of ECAP isolated from the roots of D...
May 3, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28432874/delayed-changes-in-auditory-status-in-cochlear-implant-users-with-preserved-acoustic-hearing
#14
Rachel A Scheperle, Viral D Tejani, Julia K Omtvedt, Carolyn J Brown, Paul J Abbas, Marlan R Hansen, Bruce J Gantz, Jacob J Oleson, Marie V Ozanne
This retrospective review explores delayed-onset hearing loss in 85 individuals receiving cochlear implants designed to preserve acoustic hearing at the University of Iowa Hospitals and Clinics between 2001 and 2015. Repeated measures of unaided behavioral audiometric thresholds, electrode impedance, and electrically evoked compound action potential (ECAP) amplitude growth functions were used to characterize longitudinal changes in auditory status. Participants were grouped into two primary categories according to changes in unaided behavioral thresholds: (1) stable hearing or symmetrical hearing loss and (2) delayed loss of hearing in the implanted ear...
April 12, 2017: Hearing Research
https://www.readbyqxmd.com/read/28421414/polyclonal-antibodies-in-microplates-to-predict-the-maximum-adsorption-activities-of-enzyme-mutants-from-cell-lysates
#15
Yiran Feng, Xiaolan Yang, Deqiang Wang, Xiaolei Hu, Huimin Chong, Juan Liao, Chang-Guo Zhan, Fei Liao
With microplate-immobilized polyclonal antibodies against a starting enzyme or its active mutant bearing consistent accessible epitopes, the maximum activity of an adsorbed enzyme/mutant (Vs) was predicted for comparison to recognize weakly-positive mutants. Rabbit antisera against Escherichia coli alkaline phosphatase (ECAP) were fractionated with 33% ammonium sulfate to yield crude polyclonal antibodies for conventional immobilization in 96-well microplates. The response curve of the activities of ECAP/mutant adsorbed by the immobilized polyclonal antibodies to protein quantities from a cell lysate was fit to an approximation model to predict Vs...
June 2017: Protein Journal
https://www.readbyqxmd.com/read/28385501/percutaneous-embolization-of-delayed-external-carotid-artery-pseudoaneurysm-eight-years-after-partial-parathyroidectomy
#16
Antonella Laurito, Holta Kasemi, Andrea Monti, Mauro Maselli, Paola Manzo, Valeria Tavolini, Andrea Gaggiano
External carotid artery pseudoaneurysm (ECAP) is very rare. The usual mechanism is trauma or iatrogenic. We report a case of a patient with an asymptomatic, chronic ECAP secondary to partial parathyroidectomy. Percutaneous injection of the two-component Fibrin Sealant (Tisseel, Baxter int., Deerfield, IL) with the two active ingredients (Sealer Protein Solution and Thrombin Solution) was carried out with successful occlusion of the pseudoaneurysmal sac. The six-month follow up CT scan confirmed the ECAP thrombosis...
April 3, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28338092/high-rate-squeezing-process-of-bulk-metallic-glasses
#17
Jitang Fan
High-rate squeezing process of bulk metallic glasses from a cylinder into an intact sheet achieved by impact loading is investigated. Such a large deformation is caused by plastic flow, accompanied with geometrical confinement, shear banding/slipping, thermo softening, melting and joining. Temperature rise during the high-rate squeezing process makes a main effect. The inherent mechanisms are illustrated. Like high-pressure torsion (HPT), equal channel angular pressing (ECAP) and surface mechanical attrition treatments (SMAT) for refining grain of metals, High-Rate Squeezing (HRS), as a multiple-functions technique, not only creates a new road of processing metallic glasses and other metallic alloys for developing advanced materials, but also directs a novel technology of processing, grain refining, coating, welding and so on for treating materials...
March 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28322774/development-and-reliability-of-the-new-endoscopic-virtual-chromoendoscopy-score-the-picasso-paddington-international-virtual-chromoendoscopy-score-in-ulcerative%C3%A2-colitis
#18
Marietta Iacucci, Marco Daperno, Mark Lazarev, Razvan Arsenascu, Gian Eugenio Tontini, Oluseyi Akinola, Xianyong Sean Gui, Vincenzo Villanacci, Martin Goetz, Mark Lowerison, Brendan Cord Lethebe, Maurizio Vecchi, Helmut Neumann, Subrata Ghosh, Raf Bisschops, Ralf Kiesslich
BACKGROUND AND AIMS: Endoscopic inflammation and healing are important therapeutic endpoints in ulcerative colitis (UC). We developed and validated a new electronic virtual chromoendoscopy (EVC) score that could reflect the full spectrum of mucosal and vascular changes including mucosal healing in UC. METHODS: Eight participants reviewed a 60-minute training module outlining 3 different i-SCAN modes demonstrating the entire spectrum of inflammatory mucosal and vascular changes in UC...
March 18, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28315280/beyond-white-light-optical-enhancement-in-conjunction-with-magnification-colonoscopy-for-the-assessment-of-mucosal-healing-in-ulcerative-colitis
#19
Marietta Iacucci, Ralf Kiesslich, Xianyong Gui, Remo Panaccione, Joan Heatherington, Oluseyi Akinola, Subrata Ghosh
Background and study aim The I-SCAN optical enhancement (OE) system with magnification is a recently introduced combination of optical and digital electronic virtual chromoendoscopy, which enhances mucosal and vascular details. The aim of this pilot study was to investigate the use of I-SCAN OE in the assessment of inflammatory changes in ulcerative colitis (UC). Patients and methods A total of 41 consecutive patients with UC and 9 control patients were examined by I-SCAN OE (Pentax Medical, Tokyo, Japan)...
March 17, 2017: Endoscopy
https://www.readbyqxmd.com/read/28303950/effect-of-grain-structure-on-charpy-impact-behavior-of-copper
#20
Ningning Liang, Yonghao Zhao, Jingtao Wang, Yuntian Zhu
Nanostructured (NS) and ultrafine-grained (UFG) materials have high strength and relatively low ductility. Their toughness has not been comprehensively investigated. Here we report the Charpy impact behavior and the corresponding microstructural evolutions in UFG Cu with equi-axed and elongated grains which were prepared by equal channel angular pressing (ECAP) for 2 and 16 passes at room temperature. It is found that their impact toughness (48 J/cm(2)) is almost comparable to that of coarse grained (CG) Cu: 55 J/cm(2)...
March 17, 2017: Scientific Reports
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