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https://www.readbyqxmd.com/read/27884176/localization-of-bleeding-sites-in-patients-with-hemoptysis-based-on-their-chest-computed-tomography-findings-a-retrospective-cohort-study
#1
Hyun Ju Seon, Yun-Hyeon Kim, Yong-Soo Kwon
BACKGROUND: The aim of this study was to propose a localization strategy for bleeding sites in hemoptysis patients using their chest computed tomography (CT) findings. METHODS: Between January 2005 and July 2009, the chest CT findings of 161 hemoptysis patients were retrospectively reviewed. Following chest CT, the lobe with the most prominent ground glass attenuation (GGA) or specific lesions with the potential to cause pulmonary hemorrhage were analysed to develop a localization strategy for bleeding sites...
November 25, 2016: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/27868188/patency-of-paediatric-endotracheal-tubes-for-airway-instrumentation
#2
J Elfgen, P K Buehler, J Thomas, M Kemper, S Imach, M Weiss
BACKGROUND: Airway exchange catheters (AEC) and fiberoptic bronchoscopes (FOB) for tracheal intubation are selected so that there is only a minimal gap between their outer and inner diameter of endotracheal tube (ETT) to minimize the risk of impingement during airway instrumentation. This study aimed to test the ease of passage of FOBs and AECs through paediatric ETT of different sizes and from different manufacturers when using current recommendations for dimensional equipment compatibility taken from text books and manufacturers information...
November 20, 2016: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/27867133/fiberoptic-bronchoscopy-and-remifentanil-target-controlled-infusion-in-critically-ill-patients-with-acute-hypoxaemic-respiratory-failure-a-descriptive-study
#3
Saïda Rezaiguia-Delclaux, Florent Laverdure, Talna Kortchinsky, Léa Lemasle, Audrey Imbert, François Stéphan
INTRODUCTION: Sedation optimizes patient comfort and ease of execution during fiberoptic bronchoscopy (FOB). Our objective was to describe the safety and efficacy of remifentanil-TCI during FOB in non-intubated, hypoxaemic, thoracic-surgery ICU patients. METHODS: Consecutive spontaneously breathing adults requiring FOB after thoracic surgery were included if they had hypoxaemia (PaO2/FiO2 < 300mmHg or need for non-invasive ventilation [NIV]) and prior FOB failure under topical anaesthesia...
November 17, 2016: Anaesthesia, Critical Care & Pain Medicine
https://www.readbyqxmd.com/read/27849324/pre-operative-stool-analysis-for-intestinal-parasites-and-fecal-occult-blood-in-patients-with-acute-appendicitis
#4
Sinan Hatipoğlu, Uğur Lök, Umut Gülaçtı, Tuncay Çelik
BACKGROUND: Etiology of acute appendicitis (AA) rarely involves parasitic infections of gastrointestinal (GI) tract. Preoperative diagnosis of parasitic infections in appendix remains difficult, although parasites can sometimes be observed inside the lumen during histopathological examination. The aim of the present study was to prospectively screen prevalence and species of intestinal parasites and adherence of fecal occult blood (FOB) in patients admitted to emergency department (ED) with clinical symptoms of AA who underwent appendectomy...
September 2016: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/27836611/a-sers-nano-tag-based-fiber-optic-strategy-for-in-situ-immunoassay-in-unprocessed-whole-blood
#5
Xiaokun Li, Youlin Zhang, Bin Xue, Xianggui Kong, Xiaomin Liu, Langping Tu, Yulei Chang, Hong Zhang
Assay technologies capable of detecting biomarker concentrations in unprocessed whole blood samples are fundamental for applications in medical diagnostics. SERS nano-tags integrated fiber-optic biosensor (FOB) was realized for the first time for in situ immunoassay in whole blood. The reliability and sensitivity of this method rely, in a large extent, on the quality and properties of the SERS nano-tags. The constructed silica-coated Ag SERS nano-tags as labels were used in a rapid and specific in situ FOB immune sensor to detect alpha fetoprotein (AFP) in unprocessed blood samples...
October 28, 2016: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27829418/hepatoprotective-potential-of-fagonia-olivieri-dc-against-acetaminophen-induced-toxicity-in-rat
#6
Umbreen Rashid, Muhammad Rashid Khan, Moniba Sajid
BACKGROUND: Fagonia olivieri (DC) being used for the treatment of diabetes, cancer, fever and claimed to be effective in many other stress related disorders. In this study we have evaluated the F. olivieri whole methanol extract and its derived fractions for various in vitro and in vivo antioxidant studies. METHODS: The crude methanol extract of the whole plant of F. olivieri (FOM) and its derived fractions; n-hexane (FOH), chloroform (FOC), ethyl acetate (FOE), n-butanol (FOB) and aqueous (FOA) were evaluated for the total phenolic and flavonoid content and in vitro antioxidant abilities...
November 9, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27828867/a-simple-blind-placement-of-the-left-sided-double-lumen-tubes
#7
Zhi Jun Zong, Qi Ying Shen, Yao Lu, Yuan Hai Li
One-lung ventilation (OLV) has been commonly provided by using a double-lumen tube (DLT). Previous reports have indicated the high incidence of inappropriate DLT positioning in conventional maneuvers.After obtaining approval from the medical ethics committee of First Affiliated Hospital of Anhui Medical University and written consent from patients, 88 adult patients belonging to American society of anesthesiologists (ASA) physical status grade I or II, and undergoing elective thoracic surgery requiring a left-side DLT for OLV were enrolled in this prospective, single-blind, randomized controlled study...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27815549/pregnant-women-s-attitudes-about-topical-microbicides-for-the-prevention-and-treatment-of-bacterial-vaginosis-during-pregnancy
#8
Marina Catallozzi, Lauren Dapena Fraiz, Katharine M Hargreaves, Gregory D Zimet, Lawrence R Stanberry, Adam J Ratner, Shari E Gelber, Susan L Rosenthal
We sought to understand pregnant women's product preference and likelihood of use of topical microbicides for bacterial vaginosis (BV) prevention and treatment. Pregnant women (N = 196) in a obstetrics clinic completed a survey between June 2014 and January 2015 about vaginal product use for BV. This cross-sectional study explored product preferences, likelihood of product use for BV management and father of the baby (FOB) involvement. Most participants were under 30 (68%) and underrepresented minorities (47% Hispanic, 21% African-American)...
November 4, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27795715/is-the-presence-of-the-father-of-the-baby-during-first-prenatal-ultrasound-study-visit-associated-with-improved-pregnancy-outcomes-in-adolescents-and-young-adults
#9
Sara H Lee, Rina Lazebnik, Margaret Kuper-Sassé, Noam Lazebnik
This study examined whether the presence of the father of the baby (FOB) at the first prenatal ultrasound study (US) visit of pregnant adolescents and young adults (AYA) is a marker for improved pregnancy outcomes. Charts of 400 pregnant AYA aged 14-22 years seen at an academic maternity hospital were assessed retrospectively for support persons brought to prenatal US visits. Logistic regression analysis was used to examine the association between FOB presence and gestational age and birth weight. Of 400 charts with support person recorded, 298 charts with first US visit data, singleton birth, and complete gestational data available were analyzed...
2016: International Journal of Pediatrics
https://www.readbyqxmd.com/read/27666511/clinical-cytological-and-microbiological-evaluation-of-bronchoalveolar-lavage-in-children-a-referral-hospital-based-study
#10
Babak Pourakbari, Shima Mahmoudi, Amir Hossein Jafari, Abbas Bahador, Sepideh Keshavarz Valian, Reihaneh Hosseinpour Sadeghi, Setareh Mamishi
INTRODUCTION: Diffuse lung diseases (DLD) in children involve a group of heterogeneous, rare disorders. In spite of the low diagnostic yield in pediatric DLD, bronchoalveolar lavage (BAL) can be used to diagnose specific disorders. There are few studies about microbial and cellular profiles of BAL samples in these patients. This study was conducted to evaluate the clinical, cytological and microbiological evaluation of BAL in children with DLD. METHODS: The clinical, cytological and microbiological profiles of BAL samples of all patients with DLD who underwent the fiberoptic bronchoscopy (FOB) at Children's Medical Center, an Iranian referral pediatrics Hospital during a year were evaluated...
September 22, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27659846/15-th-annual-meeting-of-the-safety-pharmacology-society-focus-on-traditional-sensory-systems
#11
Icilio Cavero, Henry Holzgrefe
INTRODUCTION: This report summarizes and comments key talks on the five traditional senses (ear, vestibular system, vision, taste, olfaction, and touch) which were delivered during the 2015 Annual Meeting of the Safety Pharmacology (SP) Society. AREAS COVERED: The functional observational battery (FOB) can detect major candidate drug liabilities only on ear, touch and vision. Anatomy, physiology, pharmacology, and pathology notions on each sensory system introduce speaker talks...
September 19, 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27649739/the-apo-structure-of-the-leucine-sensor-sestrin2-is-still-elusive
#12
Robert A Saxton, Kevin E Knockenhauer, Thomas U Schwartz, David M Sabatini
Sestrin2 is a GATOR2-interacting protein that directly binds leucine and is required for the inhibition of mTORC1 under leucine deprivation, indicating that it is a leucine sensor for the mTORC1 pathway. We recently reported the structure of Sestrin2 in complex with leucine [Protein Data Bank (PDB) ID, 5DJ4] and demonstrated that mutations in the leucine-binding pocket that alter the affinity of Sestrin2 for leucine result in a corresponding change in the leucine sensitivity of mTORC1 in cells. A lower resolution structure of human Sestrin2 (PDB ID, 5CUF), which was crystallized in the absence of exogenous leucine, showed Sestrin2 to be in a nearly identical conformation as the leucine-bound structure...
2016: Science Signaling
https://www.readbyqxmd.com/read/27637970/supraglottic-jet-oxygenation-and-ventilation-assisted-fibre-optic-bronchoscope-intubation-in-patients-with-difficult-airways
#13
Caineng Wu, Jianqi Wei, Qingyun Cen, Xuefan Sha, Qingxiang Cai, Wuhua Ma, Ying Cao
A difficult airway may lead to hypoxia and brain damage. The WEI Nasal Jet Tube (WNJ) is a new nasal pharyngeal tube that applies supraglottic jet oxygenation and ventilation (SJOV) for patients during tracheal intubation without the need for mask ventilation. We evaluated the effectiveness and safety of SJOV-assisted fibre-optic bronchoscopy (FOB) using the WNJ in the management of difficult tracheal intubations. A total of 50 adult patients with Cormack-Lehane grade ≥3 and general anesthesia with tracheal intubation were randomly assigned to either the laryngeal mask airway (LMA) or WNJ groups...
September 14, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27591769/avoiding-routine-chest-radiography-after-transbronchial-biopsy-is-safe
#14
Gabriel Izbicki, Ayal Romem, Nissim Arish, Clement Cahan, Hava Azulai, Chen Chen-Shuali, Esther Tennenhaus, Zipi Bar-Yosef, Evgeniya Zlotkevich, Ariel Rokach
BACKGROUND: Fiberoptic bronchoscopy (FOB) with transbronchial biopsy (TBB) is complicated by a pneumothorax in 1-4% of cases. Performance of routine post-TBB chest radiography (CXR) results in an extremely low diagnostic yield but nevertheless is the common clinical practice prevailing today. It has previously been suggested that routine post-TBB CXR could be avoided in asymptomatic patients. OBJECTIVE: The objective of this study was to prospectively assess the feasibility and safety of this approach...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27578926/lack-of-efficacy-of-pre-bronchoscopy-inhaled-salbutamol-on-symptoms-and-lung-functions-in-patients-with-pre-existing-airway-obstruction
#15
Anant Mohan, Indrajit Momin, Rosemary Poulose, Charu Mohan, Karan Madan, Vijay Hadda, Randeep Guleria, R M Pandey
BACKGROUND: Fiberoptic bronchoscopy (FOB) may exaggerate symptoms and lung functions in patients with pre-existing airway obstruction. Interventions which can alleviate or minimize this procedure-related bronchospasm, especially in this high-risk group are, therefore, required. METHODS: A double-blinded randomized controlled trial was conducted to evaluate the efficacy of 400 μg of inhaled salbutamol on patients with spirometric evidence of airflow obstruction planned for FOB...
July 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27534836/the-standardized-functional-observational-battery-its-intrinsic-value-remains-in-the-instrument-of-measure-the-rat
#16
David V Gauvin, Joshua D Yoder, David L Holdsworth, Marci L Harter, Jonelle R May, Noelle Cotey, Jill A Dalton, Theodore J Baird
The International Conference on Harmonisation's (ICH) Tripartite Guideline on Safety Pharmacology Studies for Human Pharmaceuticals has adopted the requirement that each new test substance must be tested for effects on the central nervous system prior to "first dose in man". This assessment is required to measure, at a minimum, the effects of the substance on general motor activity, behavioral changes, coordination, sensory/motor reflex responses, and body temperatures. To achieve this goal, ICH S7A recommends a neurobehavioral assessment (usually a functional observational battery (FOB) or modified Irwin test), which is generally undertaken in the rat...
August 14, 2016: Journal of Pharmacological and Toxicological Methods
https://www.readbyqxmd.com/read/27507905/a-randomised-comparison-of-two-faecal-immunochemical-tests-in-population-based-colorectal-cancer-screening
#17
E J Grobbee, M van der Vlugt, A J van Vuuren, A K Stroobants, M W Mundt, W J Spijker, E J C Bongers, E J Kuipers, I Lansdorp-Vogelaar, P M Bossuyt, E Dekker, M C W Spaander
OBJECTIVE: Colorectal cancer screening programmes are implemented worldwide; many are based on faecal immunochemical testing (FIT). The aim of this study was to evaluate two frequently used FITs on participation, usability, positivity rate and diagnostic yield in population-based FIT screening. DESIGN: Comparison of two FITs was performed in a fourth round population-based FIT-screening cohort. Randomly selected individuals aged 50-74 were invited for FIT screening and were randomly allocated to receive an OC -Sensor (Eiken, Japan) or faecal occult blood (FOB)-Gold (Sentinel, Italy) test (March-December 2014)...
August 9, 2016: Gut
https://www.readbyqxmd.com/read/27484225/does-molecular-analysis-increase-the-efficacy-of-bronchoalveolar-lavage-in-the-diagnosis-and-management-of-respiratory-infections-in-hemato-oncological-patients
#18
Ilana Oren, Emilia Hardak, Tsila Zuckerman, Yuval Geffen, Ron Hoffman, Mordechai Yigla, Irit Avivi
OBJECTIVES: The identification of the specific pathogen responsible for a respiratory infection in patients with hematological malignancies (HM) would ensure relevant treatment and prevent toxicity associated with anti-infective therapy. This large-scale study aimed to explore the clinical impact of fiberoptic bronchoscopy with bronchoalveolar lavage (FOB-BAL) in conjunction with molecular analysis on the diagnosis and management of respiratory infections in hemato-oncological patients...
September 2016: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/27449567/evaluation-of-first-generation-synthetic-cannabinoids-on-binding-at-non-cannabinoid-receptors-and-in-a-battery-of-in%C3%A2-vivo-assays-in-mice
#19
Jenny L Wiley, Timothy W Lefever, Julie A Marusich, Megan Grabenauer, Katherine N Moore, John W Huffman, Brian F Thomas
Anecdotal reports suggest that abused synthetic cannabinoids produce cannabis-like "highs," but some of their effects may also differ from traditional cannabinoids such as Δ(9)-tetrahydrocannabinol (THC). This study examined the binding affinities of first-generation indole-derived synthetic cannabinoids at cannabinoid and noncannabinoid receptors and their effects in a functional observational battery (FOB) and drug discrimination in mice. All seven compounds, except JWH-391, had favorable affinity (≤159 nM) for both cannabinoid receptors...
November 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27353256/maintenance-of-b-cells-during-chronic-murine-trypanosoma-brucei-gambiense-infection
#20
J Cnops, F Kauffmann, C De Trez, T Baltz, J Keirsse, M Radwanska, E Muraille, S Magez
African trypanosomosis is a debilitating parasitic disease occurring in large parts of sub-Saharan Africa. Trypanosoma brucei gambiense accounts for 98% of the reported HAT infections and causes a chronic, gradually progressing disease. Multiple experimental murine models for trypanosomosis have demonstrated inflammation-dependent apoptosis of splenic follicular B (FoB) cells and the destruction of B-cell memory against previously encountered pathogens. Here, we report that during murine infection with a chronic T...
October 2016: Parasite Immunology
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