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https://www.readbyqxmd.com/read/29221382/detailed-balance-internal-consistency-and-energy-conservation-in-fragment-orbital-based-surface-hopping
#1
Antoine Carof, Samuele Giannini, Jochen Blumberger
We have recently introduced an efficient semi-empirical non-adiabatic molecular dynamics method for the simulation of charge transfer/transport in molecules and molecular materials, denoted fragment orbital-based surface hopping (FOB-SH) [J. Spencer et al., J. Chem. Phys. 145, 064102 (2016)]. In this method, the charge carrier wavefunction is expanded in a set of charge localized, diabatic electronic states and propagated in the time-dependent potential due to classical nuclear motion. Here we derive and implement an exact expression for the non-adiabatic coupling vectors between the adiabatic electronic states in terms of nuclear gradients of the diabatic electronic states...
December 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29200902/jph203-a-selective-l-type-amino-acid-transporter-1-inhibitor-induces-mitochondria-dependent-apoptosis-in-saos2-human-osteosarcoma-cells
#2
Dae Woo Choi, Do Kyung Kim, Yoshikatsu Kanai, Michael F Wempe, Hitoshi Endou, Jong-Keun Kim
Most normal cells express L-type amino acid transporter 2 (LAT2). However, L-type amino acid transporter 1 (LAT1) is highly expressed in many tumor cells and presumed to support their increased growth and proliferation. This study examined the effects of JPH203, a selective LAT1 inhibitor, on cell growth and its mechanism for cell death in Saos2 human osteosarcoma cells. FOB human osteoblastic cells and Saos2 cells expressed LAT1 and LAT2 together with their associating protein 4F2 heavy chain, but the expression of LAT2 in the Saos2 cells was especially weak...
November 2017: Korean Journal of Physiology & Pharmacology
https://www.readbyqxmd.com/read/29180008/identification-and-characterization-of-human-bone-derived-cells
#3
Sungsin Jo, Jin Kyu Lee, Jinil Han, Bitnara Lee, Suman Kang, Kyu-Tae Hwang, Ye-Soo Park, Tae-Hwan Kim
This study was designed to identify and characterize primary bone-derived cells (BdCs) and investigate the potential role of osteoblast differentiation. Primary BdCs were isolated from surgical bone for comparative analysis with mesenchymal stem cells (MSCs) and fetal osteoblasts (FOBs) and for potential differentiation to mature osteoblasts. Using three different cells, we successfully cultivated human osteoblast differentiation and activity which were evaluated using microarray and biochemical methods. BdCs are more correlated to MSCs in bioinformatics result and similar with FOBs in gene expression...
November 24, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29131830/transcriptome-profiling-and-digital-gene-expression-analysis-of-sweet-potato-for-the-identification-of-putative-genes-involved-in-the-defense-response-against-fusarium-oxysporum-f-sp-batatas
#4
Yuli Lin, Weikun Zou, Shiqiang Lin, Dennis Onofua, Zhijian Yang, Haizhou Chen, Songliang Wang, Xuanyang Chen
Sweet potato production is constrained by Fusarium wilt, which is caused by Fusarium oxysporum f. sp. batatas (Fob). The identification of genes related to disease resistance and the underlying mechanisms will contribute to improving disease resistance via sweet potato breeding programs. In the present study, we performed de novo transcriptome assembly and digital gene expression (DGE) profiling of sweet potato challenged with Fob using Illumina HiSeq technology. In total, 89,944,188 clean reads were generated from 12 samples and assembled into 101,988 unigenes with an average length of 666 bp; of these unigenes, 62,605 (61...
2017: PloS One
https://www.readbyqxmd.com/read/29124010/positive-fecal-occult-blood-test-as-a-diagnostic-cue-for-schistosoma-mansoni-infection-in-a-developed-country
#5
Itaru Nakamura, Kenji Yagi, Takashi Kumagai, Nobuo Ohta
The rise in eco-tourism and travel off the beaten track have increased numbers of tourists with schistosomiasis which is seldom seen in developed countries, although this disease is considered a neglected tropical disease especially in poor communities. A Guinean male living in Japan was seen complaining of severe constipation. He was positive for fecal occult blood (FOB) and underwent colonoscopy. Colonoscopy showed petechiae of the rectal mucosa, with pathologic examination of biopsy tissue showing calcified eggs of the genus Schistosoma...
2017: IDCases
https://www.readbyqxmd.com/read/29090890/clinical-laboratory-improvement-amendments-of-1988-clia-fecal-occult-blood-fob-testing-final-rule
#6
(no author information available yet)
This final rule amends the Clinical Laboratory Improvement Amendments of 1988 (CLIA) regulations to clarify that the waived test categorization applies only to non-automated fecal occult blood tests.
October 20, 2017: Federal Register
https://www.readbyqxmd.com/read/29078671/use-of-autologous-platelet-rich-plasma-prp-in-stopping-massive-hemoptysis-at-the-lung-center-of-the-philippines-a-pilot-study
#7
Armand Gregorio C Sarmiento, Jose Luis J Danguilan, Zenaida M Mariano, Maria Teresa A Barzaga
BACKGROUND: The purpose of this study is to determine the effect of using autologous platelet rich plasma (PRP) in patients having massive hemoptysis within a period of one week. METHODS: This is a prospective cohort study involving 20 consecutive patients admitted who met the criteria for massive hemoptysis from July to October 2011. After stabilizing the patient, fiberoptic bronchoscopy (FOB) was performed for localization of bleeding within 6 hours from diagnosis...
2017: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29074128/a-randomized-controlled-study-of-the-use-of-video-double-lumen-endobronchial-tubes-versus-double-lumen-endobronchial-tubes-in-thoracic-surgery
#8
Jagtar Singh Heir, Shu-Lin Guo, Ronaldo Purugganan, Tim A Jackson, Anupamjeet Kaur Sekhon, Kazim Mirza, Javier Lasala, Lei Feng, Juan P Cata
OBJECTIVE: To compare the incidence of fiberoptic bronchoscope (FOB) use (1) during verification of initial placement and (2) for reconfirmation of correct placement following repositioning, when either a double-lumen tube (DLT) or video double-lumen tube (VDLT) was used for lung isolation during thoracic surgery. DESIGN: A randomized controlled study. SETTING: Single-center university teaching hospital. PARTICIPANTS: The study comprised 80 patients who were 18 years or older requiring lung isolation for surgery...
May 9, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29057487/a-systematic-review-of-nonpharmacological-prenatal-interventions-for-pregnancy-specific-anxiety-and-fear-of-childbirth
#9
Kathrin Stoll, Emma Marie Swift, Nichole Fairbrother, Elizabeth Nethery, Patricia Janssen
BACKGROUND: Despite a sharp increase in the number of publications that report on treatment options for pregnancy-specific anxiety and fear of childbirth (PSA/FoB), no systematic review of nonpharmacological prenatal interventions for PSA/FoB has been published. Our team addressed this gap, as an important first step in developing guidelines and recommendations for the treatment of women with PSA/FoB. METHODS: Two databases (PubMed and Mendeley) were searched, using a combination of 42 search terms...
October 23, 2017: Birth
https://www.readbyqxmd.com/read/28981579/comparison-of-the-paediatric-blade-of-the-pentax-aws-and-ovassapian-airway-in-fibreoptic-tracheal-intubation-in-patients-with-limited-mouth-opening-and-cervical-spine-immobilization-by-a-semi-rigid-neck-collar-a-randomized-controlled-trial
#10
D H Kim, J Y Yoo, S Y Ha, Y J Chae
Background: We compared the performances of the paediatric blade of a Pentax Airway Scope and an Ovassapian airway in fibreoptic tracheal intubation in patients whose necks were stabilized by semi-rigid neck collars. Methods: Ninety patients were enrolled in this prospective, open-label, randomized controlled trial. Patients were randomly allocated to one of two groups (Group OVA-FOB and Group AWS-FOB). The time to tracheal intubation, success rate of tracheal intubation, number of optimization manoeuvres (jaw thrust), and difficulty of manipulation of the fibreoptic bronchoscope were compared between the groups...
November 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/28974913/successful-endotracheal-intubation-with-trachway-after-failed-fiber-optic-manipulations-in-a-patient-with-retropharyngeal-cervical-chordoma
#11
Yi-Ting Chen, Chun-Ning Ho, Kuo-Chuan Hung
A retropharyngeal mass may distort the airway anatomy and reduce the space available for manipulation of intubation devices. We encountered a patient with a cervical chordoma occupying the retropharyngeal space. Fiber-optic orotracheal intubation was attempted to secure the airway. Although the fiber-optic bronchoscope (FOB) was successfully placed into the trachea, the tracheal tube could not be passed through the glottis. An airway was then successfully established with the Trachway device, a video-assisted system with a rigid but malleable intubating stylet...
July 2017: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/28831445/comparison-of-symptom-score-and-bronchoscopy-based-assessment-with-conventional-computed-tomography-based-assessment-of-response-to-chemotherapy-in-lung-cancer
#12
Lakshimikant Baburao Yenge, Digambar Behera, Mandeep Garg, Ashutosh Nath Aggarwal, Navneet Singh
PURPOSE: There is a paucity of literature on symptom score (SS) plus fiberoptic bronchoscopy (FOB) -based response evaluation (RE) to chemotherapy for lung cancer. This study aimed to compare the reliability of RE by SS, chest radiograph (CXR), and FOB with computed tomography (CT) -based assessment (Response Evaluation Criteria in Solid Tumors (RECIST) and WHO criteria) for lung cancer chemotherapy. METHODS: This was a prospective observational study involving treatment-naïve patients with lung cancer planned for chemotherapy, with one or more lesions on FOB and CT...
August 2017: Journal of Global Oncology
https://www.readbyqxmd.com/read/28771240/selecting-a-cut-off-for-colorectal-cancer-screening-with-a-fecal-immunochemical-test
#13
Hermann Brenner, Simone Werner
OBJECTIVES: Fecal immunochemical tests (FITs) for hemoglobin (Hb) are increasingly used for colorectal cancer (CRC) screening. However, cut-offs for defining test positivity are varying widely. We aimed to evaluate the impact of cut-off selection on key indicators of diagnostic performance in a true screening setting. METHODS: We evaluated diagnostic performance of FOB Gold, a widely used quantitative FIT, for detecting advanced neoplasms (AN) across a wide range of possible cut-offs among 1822 participants of screening colonoscopy aged 50-79 years in Germany...
August 3, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28761377/fecal-occult-blood-versus-dna-testing-indirect-comparison-in-a-colorectal-cancer-screening-population
#14
Hermann Brenner, Hongda Chen
BACKGROUND: A multitarget stool DNA test (MSDT) that showed higher sensitivity but lower specificity than a fecal immunochemical test (FIT) for hemoglobin in one recent study from the US and Canada, is increasingly used for colorectal cancer (CRC) screening, despite its ~20-fold higher costs compared to FITs. We aimed to assess diagnostic performance of a quantitative FIT in an independent study among participants of screening colonoscopy and to compare it with the previously reported performance of MSDT...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28756932/fear-of-childbirth-and-depressive-symptoms-among-postnatal-women-a-cross-sectional-survey-from-chhattisgarh-india
#15
Paridhi Jha, Margareta Larsson, Kyllike Christensson, Agneta Skoog Svanberg
BACKGROUND: Prevalence rates of Fear of Birth and postnatal depressive symptoms have not been explored in Chhattisgarh, India. OBJECTIVE: To validate Hindi Wijma Delivery Experience Questionnaire and to study the prevalence of Fear of Birth and depressive symptoms among postnatal women. METHODS: A cross-sectional survey at seventeen public health facilities in two districts of Chhattisgarh, India among postnatal women who gave birth vaginally or through C-section to a live neonate...
July 27, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28689708/the-growing-role-of-biologics-and-biosimilars-in-the-united-states-perspectives-from-the-apha-biologics-and-biosimilars-stakeholder-conference
#16
Judy Crespi-Lofton, Jann B Skelton
OBJECTIVES: The American Pharmacists Association (APhA) convened the Biologics and Biosimilars Stakeholder Conference on November 30, 2016, in Washington DC. The objectives of the Conference were to determine the key issues and challenges within the marketplace for biologics, follow-on biologics (FOBs), and biosimilars, identify potential roles and responsibilities of pharmacists regarding biologic and biosimilar medications, and identify actions or activities that pharmacists may take to optimize the safe and cost-effective use of biologics and biosimilars...
July 6, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28667653/occurrence-of-bronchial-anthracofibrosis-in-respiratory-symptomatics-with-exposure-to-biomass-fuel-smoke
#17
Vikas Pilaniya, Shekhar Kunal, Ashok Shah
INTRODUCTION: Bronchial anthracofibrosis (BAF), confirmed bronchoscopically, is characterised by bluish-black mucosal pigmentation and distortion/narrowing of the bronchus. We investigated the occurrence of BAF in respiratory symptomatics with biomass fuel smoke exposure and evaluated its clinico-radiological attributes and impact on functional status. MATERIAL AND METHODS: Of the eighty subjects evaluated, 60 consented for fiberoptic bronchoscopy (FOB). All 60 subjects also underwent chest radiography, high resolution computed tomography (HRCT) of the thorax, complete pulmonary function testing including diffusion capacity and six-minute-walk test...
2017: Advances in Respiratory Medicine
https://www.readbyqxmd.com/read/28663626/proseal-laryngeal-mask-airway-placement-a-comparison-of-blind-versus-direct-laryngoscopic-insertion-techniques
#18
Pooja Chandrakanth Patil, Manjunath Abloodu Chikkapillappa, Vinayak Seenappa Pujara, Tejesh Channasandra Anandswamy, Leena Harshad Parate, Yatish Bevinaguddaiah
BACKGROUND AND OBJECTIVES: The laryngeal mask airway (LMA) ProSeal is most commonly used supraglottic airway device; it is routinely inserted by blind technique. Although blind insertion technique is most widely used, there are many techniques which are available such as priming the drain tube with a guiding instrument such as a suction catheter, a gum elastic bougie, a Flexi-Slip Stylet, direct laryngoscopy, and even a fiber-optic bronchoscope (FOB). The present study was undertaken to compare and assess the placement of LMA ProSeal using blind versus direct laryngoscopy techniques using FOB...
April 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28643629/faecal-immunochemical-tests-to-triage-patients-with-lower-abdominal-symptoms-for-suspected-colorectal-cancer-referrals-in-primary-care-a-systematic-review-and-cost-effectiveness-analysis
#19
Marie Westwood, Isaac Corro Ramos, Shona Lang, Marianne Luyendijk, Remziye Zaim, Lisa Stirk, Maiwenn Al, Nigel Armstrong, Jos Kleijnen
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer in the UK. Presenting symptoms that can be associated with CRC usually have another explanation. Faecal immunochemical tests (FITs) detect blood that is not visible to the naked eye and may help to select patients who are likely to benefit from further investigation. OBJECTIVES: To assess the effectiveness of FITs [OC-Sensor (Eiken Chemical Co./MAST Diagnostics, Tokyo, Japan), HM-JACKarc (Kyowa Medex/Alpha Laboratories Ltd, Tokyo, Japan), FOB Gold (Sentinel/Sysmex, Sentinel Diagnostics, Milan, Italy), RIDASCREEN Hb or RIDASCREEN Hb/Hp complex (R-Biopharm, Darmstadt, Germany)] for primary care triage of people with low-risk symptoms...
May 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28560146/endobronchial-primary-large-b-cell-non-hodgkin-lymphoma-in-hiv-infected-patient-in-the-highly-active-antiretroviral-therapy-era-description-of-a-case-report
#20
U Caterino, O Tambaro, G Palmiero, F Borrelli, M Cotugno, G Bonadies
We report an unusual case of endobronchial primary large B-cell Non Hodgkin Lymphoma in a HIV-infected patient in the course of effective Highly Active Antiretroviral Therapy (HAART). Diagnosis of large B-cell NHL was obtained by fibreoptic bronchoscopy (FOB) biopsies. Three cycles of R-CHOP chemotherapy (rituximab, vincristine, cyclophosphamide, hydroxydaunorubicin, prednisone) was performed and clinical and radiological remission was obtained after 3 cycles of therapy.
2017: Respiratory Medicine Case Reports
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