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Immunonutrition

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https://www.readbyqxmd.com/read/29623417/peri-operative-oral-immunonutrition-in-malnourished-ovarian-cancer-patients-assessed-by-the-nutritional-risk-screening
#1
Linda Hertlein, Christine Zeder-Göß, Sophie Fürst, Daniela Bayer, Fabian Trillsch, Bastian Czogalla, Sven Mahner, Alexander Burges, Peter Rittler
OBJECTIVES: Aim of this study was to determine whether peri-operative immunonutrition can decrease complications and the length of stay (LOS) in malnourished ovarian cancer patients. STUDY DESIGN: Patients suspicious for advanced ovarian cancer before histopathological diagnosis and a nutritional risk score (NRS) ≥ 3 received oral immune-modulating diets (IMDs) for 5 days pre-operative and at least 5 days post-operative. Parameters for clinical outcome were infectious and non-infectious complications during hospital stay, and time of hospitalization...
April 5, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29596212/perioperative-nutritional-optimization-in-spine-surgery
#2
Rabia Qureshi, Mohammad Rasool, Varun Puvanesarajah, Hamid Hassanzadeh
Nutritional optimization in patients undergoing spine surgery is important as improved surgical outcomes and decreased rates of complications have been noted in optimized patients. With the increasingly high numbers of elderly patient and patients with metabolic comorbidities undergoing spine procedures, perioperative nutritional status should be enhanced for the best possible surgical outcomes. Methods of optimization include preoperative screening with Nutritional Risk Score or other scoring systems, looking for changes in body mass index, detecting sarcopenia, and screening for metabolic abnormalities...
April 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29594107/effects-of-enteral-immunonutrition-in-esophageal-cancer
#3
REVIEW
Kenji Mimatsu, Nobutada Fukino, Yasuo Ogasawara, Yoko Saino, Takatsugu Oida
Background: Immunonutrition (IN) significantly reduces the incidence of postoperative infectious complications and the length of hospitalization in patients undergoing major elective surgery for gastrointestinal malignances. However, the clinical benefit of IN in patients who have undergone esophagectomy for esophageal cancer is unclear. Moreover, the effect of enteral IN in patients during preoperative adjuvant chemoradiotherapy and in patients treated with concurrent chemoradiotherapy for advanced esophageal cancer is unknown...
February 2018: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/29533110/the-impact-of-postoperative-enteral-immunonutrition-on-postoperative-complications-and-survival-in-gastric-cancer-patients-randomized-clinical-trial
#4
Lucyna Scislo, Radoslaw Pach, Anna Nowak, Elzbieta Walewska, Malgorzata Gadek, Philip Brandt, Grazyna Puto, Antoni M Szczepanik, Jan Kulig
BACKGROUND: Immunomodulating enteral nutrition in the perioperative period may reduce postoperative complications in cancer patients. Little is known if this effect translates to the better survival. The aim of study was to assess the impact of postoperative immunomodulating enteral nutrition on postoperative complications and survival of gastric cancer patients. METHODS: A group of 98 gastric cancer patients was randomly assigned for postoperative immunomodulating enteral nutrition n = 44 (Reconvan, Fresenius Kabi, Bad Homburg, Germany), or standard enteral nutrition n = 54 (Peptisorb, Nutricia, Schipol, The Netherlands)...
March 13, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29521674/feasibility-of-laparoscopy-assisted-gastrectomy-for-gastric-cancer-in-elderly-patients-a-case-control-study
#5
Nobuhiro Tsuchiya, Chikara Kunisaki, Hirochika Makino, Jun Kimura, Ryo Takagawa, Sho Sato, Yusaku Tanaka, Kei Sato, Hiroshi Miyamoto, Takashi Kosaka, Hirotoshi Akiyama, Itaru Endo, Kentaro Sakamaki, Takeharu Yamanaka
PURPOSE: The present study evaluated the safety and effectiveness of laparoscopic gastrectomy (LG) in elderly gastric cancer patients. PATIENTS AND METHODS: This study included 78 gastric cancer patients aged 80 years or above [39 in the LG group and 39 in the open gastrectomy group (matched)]. Patient characteristics, surgical outcomes, survival time, and immunonutritional status were compared. RESULTS: Mean blood loss was significantly lower in the LG group, although the operation time did not differ...
April 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29518432/perioperative-immunonutrition-modulates-inflammatory-response-after-radical-cystectomy-results-of-a-pilot-randomized-controlled-clinical-trial
#6
Jill M Hamilton-Reeves, Abigail Stanley, Misty D Bechtel, Thomas M Yankee, Prabhakar Chalise, Lauren K Hand, Eugene K Lee, Woodson Smelser, Moben Mirza, Hadley Wyre, Holly Hull, Susan E Carlson, Jeffrey M Holzbeierlein
PURPOSE: Poor preoperative nutritional status is associated with higher complication rates in bladder cancer patients after radical cystectomy (RC). Given the short lag time between diagnosis and RC, we compared a short-term Specialized IMmunonutrition (SIM) to a standard oral nutrition supplement (ONS) on the acute inflammatory response and arginine status in RC patients. MATERIALS AND METHODS: Twenty-nine men received SIM (n = 14) or ONS (n = 15) to drink three cartons/day for five days before and five days after RC in a prospective, randomized study...
March 5, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29465425/optimization-of-nutrition-during-allogeneic-hematologic-stem-cell-transplantation
#7
Annic Baumgartner, Katja Hoskin, Philipp Schuetz
PURPOSE OF REVIEW: Malnutrition before and during hematopoietic stem cell transplantation (HSCT) is an independent risk factor for mortality in patients undergoing hematopoietic stem cell transplantation. Yet, optimal use of nutritional support to improve outcomes remains controversial. Our aim was to do an up-to-date literature review regarding nutritional therapy in allogeneic HSCT, the neutropenic diet and the use of immunonutrients. RECENT FINDINGS: Several observational studies find malnutrition to be associated with poor outcome, increased complications and lower overall survival...
February 19, 2018: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29420749/prospective-randomized-investigation-implementing-immunonutritional-therapy-using-a-nutritional-supplement-with-a-high-blend-ratio-of-%C3%AF-3-fatty-acids-during-the-perioperative-period-for-head-and-neck-carcinomas
#8
Nobuhiro Hanai, Hoshino Terada, Hitoshi Hirakawa, Hidenori Suzuki, Daisuke Nishikawa, Shintaro Beppu, Yasuhisa Hasegawa
Objectives: The purpose of this study is to evaluate whether a nutritional supplement with a high blend ratio of ω-3 fatty acids can minimize weight loss and attenuate increases in inflammatory marker levels during the perioperative period in patients undergoing surgery for head and neck carcinoma. Methods: Patients with ≥5% weight loss within 6 months were considered as targets for aggressive nutritional intervention. Among these patients, those with head and neck squamous cell carcinoma, who underwent major invasive surgery with free flap reconstruction were included in the present study...
February 6, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29413016/nutritional-therapy-in-gastrointestinal-cancers
#9
REVIEW
Priscila Garla, Dan Linetzky Waitzberg, Alweyd Tesser
Malnutrition is the most frequent nutritional disorder in patients with gastrointestinal cancer and is associated with cachexia syndrome, worsening of prognosis, and shortened survival rate. Early nutrition screening, assessment, and intervention are able to favorably modify the clinical evolution of affected patients. The adequate provision of nutritional requirements has been associated with improvement of immunologic status, and avoidance of further complications related to poor nutritional status, surgical treatment, and anticancer therapy...
March 2018: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/29368455/effect-of-preoperative-immunonutrition-on-postoperative-short-term-outcomes-of-patients-with-head-and-neck-squamous-cell-carcinoma
#10
Carla Aeberhard, Catherine Mayer, Simone Meyer, Simon Andreas Mueller, Philipp Schuetz, Zeno Stanga, Roland Giger
BACKGROUND: Patients with head and neck squamous cell carcinoma (HNSCC) often acquire an impaired nutritional status resulting in compromised outcomes. Perioperative immunonutrition may have a positive effect on outcomes after elective surgery. METHODS: Short-term outcomes before and after implementation of preoperative immunonutrition were retrospectively assessed. Regression models adjusted for outcome predictors were used to compare the length of stay (LOS) in the hospital, local infections, and general complications...
January 24, 2018: Head & Neck
https://www.readbyqxmd.com/read/29338698/enteral-immunonutrition-versus-enteral-nutrition-for-gastric-cancer-patients-undergoing-a-total-gastrectomy-a-systematic-review-and-meta-analysis
#11
Ying Cheng, Junfeng Zhang, Liwei Zhang, Juan Wu, Zhen Zhan
BACKGROUND: Nutrition support is a common means for patients with gastric cancer, especially for those undergoing elective surgery. Recently, enteral immunonutrition (EIN) was increasingly found to be more effective than enteral nutrition (EN) in enhancing the host immunity and eventually improving the prognosis of gastric cancer patients undergoing gastrectomy. However, the results reported were not consistent. This meta-analysis aimed to assess the impact of EIN for patients with GC on biochemical, immune indices and clinical outcomes...
January 16, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29335838/effect-of-immunonutrition-on-colorectal-cancer-patients-undergoing-surgery-a-meta-analysis
#12
Jing Xu, Xian Sun, Qianqian Xin, Ying Cheng, Zhen Zhan, Junfeng Zhang, Juan Wu
PURPOSE: Immunonutrition has been used to prevent the complications after colorectal elective surgery. This systematic review aimed to analyze and assess the effect of immunonutrition on colorectal cancer patients who received elective surgery. METHODS: Three electronic databases (Medline, Embase, Cochrane) were used to search the latent studies which investigated the effects of enteral immunonutrition (EIN) compared with standard enteral nutrition (EN) or parenteral immunonutrition (PIN) compared with standard parenteral nutrition (PN) on colorectal cancer patients who are undergoing surgery until 21st of April, 2017...
March 2018: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29238571/immunonutrition-within-enhanced-recovery-after-surgery-eras-an-unresolved-matter
#13
EDITORIAL
Ruchir Gupta, Anthony Senagore
Preoperative malnutrition because of poor oral intake significantly increases the risk of adverse events after surgery and leads to increased length of stay. While immunonutrition has been utilized in the non-ERAS setting, its utility in both minimally invasive surgery and ERAS pathway procedures remain poorly defined. There are at least ten meta-analyses regarding the assessment of immunonutrition, but virtually, all of these were performed in an era prior to minimally invasive surgery, adoption of enhanced recovery protocols, and an understanding of the assessment and physiology of sarcopenia...
2017: Perioperative Medicine
https://www.readbyqxmd.com/read/29185631/-myths-and-reality-about-immunonutrition-in-uro-oncology
#14
Yannick Cerantola
Postoperative morbidity remains a nightmare (although vivid), both for the patient and the surgeon. One phantasmagorical idea would be to give the patient a « magic potion » preoperatively aiming at eliminating the risk of postoperative complication. The purpose of the present review is to summarize the current knowledge on the potential benefits of immunonutrition administered to urological cancers patients. After a brief summary on the role of immunity in cancer surveillance and treatment, the rationale about administrating oral nutritional supplements able to modulate the patient's immune system before cystectomy for bladder cancer will be highlighted...
November 29, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29181067/preoperative-immunonutrition-regulates-tumor-infiltrative-lymphocytes-and-increases-tumor-angiogenesis-in-gastric-cancer-patients
#15
Kivanc Derya Peker, Sidika Seyma Ozkanli, Cebrail Akyuz, Orhan Uzun, Necdet Fatih Yasar, Mustafa Duman, Sinan Yol
Introduction: An increased number of tumor infiltrative lymphocytes (TILs) is considered a favorable prognostic factor in various cancers because it is a marker of antitumoral activity of the immune system. In this prospective, non-randomized clinical trial, we evaluated the impact of preoperative immunonutrition on tumor infiltrative lymphocytes and neoangiogenesis in cancerous tissue in patients with locoregional and resectable gastric adenocarcinoma. Material and methods: Patients with locoregional and resectable gastric adenocarcinoma were divided non-randomly into two study groups...
October 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29169443/perioperative-preparation-and-nutritional-considerations-for-patients-undergoing-urinary-diversion
#16
REVIEW
Jessie R Gills, Jeffrey M Holzbeierlein
Patients undergoing urinary diversion are at high risk for complications in the perioperative period. The exact cause of these complications remains poorly defined but is likely multifactorial. Current efforts to optimize patients in the perioperative period, including prehabilitation, smoking cessation, recognition and treatment of comorbid conditions and malnutrition, immunonutrition supplementation, carbohydrate loading, and prevention of known complications and implementation of enhanced recovery after surgery pathways, seem beneficial in helping to improve outcomes in this at-risk population...
February 2018: Urologic Clinics of North America
https://www.readbyqxmd.com/read/29156839/the-benefit-of-immunonutrition-in-patients-undergoing-hepatectomy-a-systematic-review-and-meta-analysis
#17
Chengshuo Zhang, Baomin Chen, Ao Jiao, Feng Li, Bowen Wang, Ning Sun, Jialin Zhang
Perioperative immunonutrition in liver resection remains doubtful. A systematic review and meta-analysis was conducted to compare postoperative outcomes between patients undergoing hepatectomy who received perioperative immunonutrition and those who did not.A PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Knowledge database search was performed to retrieve all of the randomized controlled trials (RCTs) evaluating the value of perioperative immunonutrition in patients undergoing hepatectomy until the end of September 2016...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29130226/-prevention-and-treatment-of-perioperative-non-surgery-related-complications-in-elderly-patients-with-gastric-cancer
#18
Sheng Lu, Min Yan
The incidence of elderly gastric cancer patients is increasing, since the average life span is longer than ever before and the medical management is improved. Elderly patients usually have more comorbidities due to gradual loss of immunonutritional and functional status, leading to a higher rate of non-surgery-related postoperative morbidity and mortality. Along with the development of surgical and nursing technique, more and more surgeons would perform surgical procedures on elderly gastric cancer patients without hesitation...
October 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29066730/neutrophil-lymphocyte-ratio-plus-prognostic-nutritional-index-predicts-the-outcomes-of-patients-with-unresectable-hepatocellular-carcinoma-after-transarterial-chemoembolization
#19
Chang Liu, Lei Li, Wu-Sheng Lu, Hua Du, Lu-Nan Yan, Jia-Yin Yang, Tian-Fu Wen, Guo-Jun Zeng, Li Jiang, Jian Yang
For many malignancies, inflammation-based scores correlate with survival. The neutrophil-to-lymphocyte ratio (NLR) and prognostic nutritional index (PNI) are immunonutritional indices associated with postoperative outcomes in patients with hepatocellular carcinoma (HCC). We evaluated whether a combined preoperative NLR and PNI score was prognostically superior to either index alone in 793 patients with unresectable HCC after transarterial chemoembolization. Patient demographic, clinical, and pathological data were also collected and analysed...
October 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29035319/nutritional-therapy-in-liver-transplantation
#20
REVIEW
Ahmed Hammad, Toshimi Kaido, Vusal Aliyev, Claudia Mandato, Shinji Uemoto
Protein-energy malnourishment is commonly encountered in patients with end-stage liver disease who undergo liver transplantation. Malnutrition may further increase morbidity, mortality and costs in the post-transplantation setting. The importance of carefully assessing the nutritional status during the work-up of patients who are candidates for liver replacement is widely recognized. The metabolic abnormalities induced by liver failure render the conventional assessment of nutritional status to be challenging...
October 16, 2017: Nutrients
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