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https://www.readbyqxmd.com/read/28429776/global-distribution-of-particle-phase-state-in-atmospheric-secondary-organic-aerosols
#1
Manabu Shiraiwa, Ying Li, Alexandra P Tsimpidi, Vlassis A Karydis, Thomas Berkemeier, Spyros N Pandis, Jos Lelieveld, Thomas Koop, Ulrich Pöschl
Secondary organic aerosols (SOA) are a large source of uncertainty in our current understanding of climate change and air pollution. The phase state of SOA is important for quantifying their effects on climate and air quality, but its global distribution is poorly characterized. We developed a method to estimate glass transition temperatures based on the molar mass and molecular O:C ratio of SOA components, and we used the global chemistry climate model EMAC with the organic aerosol module ORACLE to predict the phase state of atmospheric SOA...
April 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28428637/surgery-metabolic-surgery-the-cutting-edge-of-diabetes-care
#2
Francesco Rubino, Spyros Panagiotopoulos
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28427842/predominance-of-international-clone-2-oxa-23-producing-acinetobacter-baumannii-clinical-isolates-in-greece-2015-results-of-a-nationwide-study
#3
Spyros Pournaras, Konstantina Dafopoulou, Mariateresa Del Franco, Olympia Zarkotou, Evangelia Dimitroulia, Efi Protonotariou, Aggeliki Poulou, Raffaele Zarrilli, Athanasios Tsakris
In a previous nationwide study in Greece, OXA-58 was the sole carbapenemase present among carbapenem-resistant Acinetobacter baumannii (CRAB) isolated between 2000 and 2009. In this study, the antibiotic resistances, carbapenemase gene content and clonal relatedness of 194 single-patient CRAB clinical isolates collected randomly during 2015 from 11 tertiary hospitals located throughout Greece were investigated. Antimicrobial susceptibility was determined using commercial and dilution methods. PCR for carbapenemase genes were performed...
April 18, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28425061/gray-matter-and-white-matter-changes-in-non-demented-amyotrophic-lateral-sclerosis-patients-with-or-without-cognitive-impairment-a-combined-voxel-based-morphometry-and-tract-based-spatial-statistics-whole-brain-analysis
#4
Foteini Christidi, Efstratios Karavasilis, Franz Riederer, Ioannis Zalonis, Panagiotis Ferentinos, Georgios Velonakis, Sophia Xirou, Michalis Rentzos, Georgios Argiropoulos, Vasiliki Zouvelou, Thomas Zambelis, Athanasios Athanasakos, Panagiotis Toulas, Konstantinos Vadikolias, Efstathios Efstathopoulos, Spyros Kollias, Nikolaos Karandreas, Nikolaos Kelekis, Ioannis Evdokimidis
The phenotypic heterogeneity in amyotrophic lateral sclerosis (ALS) implies that patients show structural changes within but also beyond the motor cortex and corticospinal tract and furthermore outside the frontal lobes, even if frank dementia is not detected. The aim of the present study was to investigate both gray matter (GM) and white matter (WM) changes in non-demented amyotrophic lateral sclerosis (ALS) patients with or without cognitive impairment (ALS-motor and ALS-plus, respectively). Nineteen ALS-motor, 31 ALS-plus and 25 healthy controls (HC) underwent 3D-T1-weighted and 30-directional diffusion-weighted imaging on a 3 T MRI scanner...
April 19, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28423791/medical-text-classification-using-convolutional-neural-networks
#5
Mark Hughes, Irene Li, Spyros Kotoulas, Toyotaro Suzumura
We present an approach to automatically classify clinical text at a sentence level. We are using deep convolutional neural networks to represent complex features. We train the network on a dataset providing a broad categorization of health information. Through a detailed evaluation, we demonstrate that our method outperforms several approaches widely used in natural language processing tasks by about 15%.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28420222/how-sensors-might-help-define-the-external-exposome
#6
REVIEW
Miranda Loh, Dimosthenis Sarigiannis, Alberto Gotti, Spyros Karakitsios, Anjoeka Pronk, Eelco Kuijpers, Isabella Annesi-Maesano, Nour Baiz, Joana Madureira, Eduardo Oliveira Fernandes, Michael Jerrett, John W Cherrie
The advent of the exposome concept, the advancement of mobile technology, sensors, and the "internet of things" bring exciting opportunities to exposure science. Smartphone apps, wireless devices, the downsizing of monitoring technologies, along with lower costs for such equipment makes it possible for various aspects of exposure to be measured more easily and frequently. We discuss possibilities and lay out several criteria for using smart technologies for external exposome studies. Smart technologies are evolving quickly, and while they provide great promise for advancing exposure science, many are still in developmental stages and their use in epidemiology and risk studies must be carefully considered...
April 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28418785/metabolomics-analysis-of-the-osteogenic-differentiation-of-umbilical-cord-blood-mesenchymal-stem-cells-reveals-differential-sensitivity-to-osteogenic-agents
#7
Michail E Klontzas, Spyros I Vernardis, Manolis Heliotis, Eleftherios Tsiridis, Athanasios Mantalaris
Mesenchymal stem cells (MSCs) of fetal origin, such as umbilical cord blood MSCs (UCB MSCs), have emerged as a promising cell source for musculoskeletal tissue regeneration because of their higher proliferation potential, lack of donor site morbidity, and their off-the-shelf potential. MSCs differentiated toward the osteogenic lineage exhibit a specific metabolic phenotype characterized by reliance to oxidative phosphorylation for energy production and reduced glycolytic rates. Currently, limited information exists on the metabolic transitions at different stages of the osteogenic process after osteoinduction with different agents...
April 18, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28413148/incorporating-site-less-clinical-trials-into-drug-development-a-framework-for-action
#8
Irl B Hirsch, Joe Martinez, E Ray Dorsey, Gerald Finken, Alexander Fleming, Chris Gropp, Philip Home, Daniel I Kaufer, Spyros Papapetropoulos
PURPOSE: Options for leveraging available telemedicine technologies, ranging from simple webcams and telephones to smartphone apps and medical-grade wearable sensors, are evolving faster than the culture of clinical research. Until recently, most clinical trials relied on paper-based processes and technology. This cost- and labor-intensive system, while slowly changing, remains an obstacle to new drug development. Alternatives that use existing tools and processes for collecting real-world data in home settings warrant closer examination...
April 13, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28407269/clinical-functional-and-inflammatory-characteristics-in-patients-with-pauci-granulocytic-stable-asthma-comparison-with-different-sputum-phenotypes
#9
Polyxeni Ntontsi, Stelios Loukides, Petros Bakakos, Konstantinos Kostikas, Georgios Papatheodorou, Evgenia Papathanassiou, Georgios Hillas, Nikolaos Koulouris, Spyros Papiris, Andriana I Papaioannou
BACKGROUND: According to induced sputum cell count, four different asthma phenotypes have been recognised(eosinophilic, neutrophilic, mixed and pauci-granulocytic). The aim of the present study was to detect functional and inflammatory characteristics of patients with pauci-granulocytic asthma. METHODS: 240 asthmatic patients were categorised in the four phenotypes according to cell counts in induced sputum. All patients underwent pulmonary function tests, and measurement of FeNO...
April 13, 2017: Allergy
https://www.readbyqxmd.com/read/28399528/phonological-process-occurrence-in-typically-developing-toddlers
#10
Kakia Petinou, Spyros Armostis
BACKGROUND/AIMS: The study examined the phonological development in Cypriot Greek (CG)-speaking, typically developing (TD) toddlers for the purpose of observing occurrences of initial consonant deletion (ICD), regressive assimilation (RAS), and their interactive relationship as a function of time. PARTICIPANTS AND METHODS: Subjects were 8 CG-speaking TD toddlers assessed longitudinally at ages 24-28 and 32-36 months. Word targets from spontaneously produced utterances via language sample collection were analyzed for the percentage of occurrence of ICD and RAS...
April 12, 2017: Folia Phoniatrica et Logopaedica
https://www.readbyqxmd.com/read/28396112/the-association-between-serum-periostin-and-a-type-2-helper-airway-composite-index-in-optimally-treated-asthmatics
#11
Elissavet Konstantellou, Stelios Loukides, Polyxeni Ntontsi, Evgenia Papathanasiou, Konstantinos Kostikas, Georgios Paptheodorou, Georgios Hillas, Spyros Papiris, Nikolaos G Koulouris, Petros Bakakos
No abstract text is available yet for this article.
April 7, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28386903/long-term-broiler-litter-amendments-can-alter-the-soil-s-capacity-to-sorb-monensin
#12
Sarah A Doydora, Peizhe Sun, Miguel Cabrera, Nehru Mantripragada, John Rema, Spyros G Pavlostathis, Ching-Hua Huang, Aaron Thompson
Monensin is a common antiparasitic drug given to poultry that contaminates poultry manure and bedding material (broiler litter). As broiler litter is commonly applied to agricultural fields as fertilizer, monensin could be released beyond the farm if it is not retained or degraded in the soil. This study aimed to assess the impact of long-term surface application of broiler litter (i.e., 17 years) on the capacity of pasture soil to sorb monensin. The soils were exposed to a range of monensin concentrations (0...
April 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28382220/abnormal-central-motor-conduction-at-the-upper-but-not-lower-limbs-correlates-with-severe-cervical-spondylosis-discussion-of-an-unexpected-observation
#13
Spyros N Deftereos
INTRODUCTION: A novel pattern of transcranial magnetic stimulation (TMS) abnormalities in cervical spondylotic myelopathy (CSM) comprising abnormal central motor conduction time (CMCT) to the upper limbs and normal CMCT to the lower limbs was observed. CSM was more severe radiologically and tended to be more severe clinically when this pattern was encountered. CASE PRESENTATION: To further characterize this observation, 414 consecutive TMS evaluations of cervical spondylosis were reviewed...
2017: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/28377145/lung-cancer-in-patients-with-idiopathic-pulmonary-fibrosis
#14
REVIEW
Theodoros Karampitsakos, Vasilios Tzilas, Rodoula Tringidou, Paschalis Steiropoulos, Vasilis Aidinis, Spyros A Papiris, Demosthenes Bouros, Argyris Tzouvelekis
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease of unknown etiology. With a gradually increasing worldwide prevalence and a mortality rate exceeding that of many cancers, IPF diagnosis and management are critically important and require a comprehensive multidisciplinary approach. This approach also involves assessment of comorbid conditions, such as lung cancer, that exerts a dramatic impact on disease survival. Emerging evidence suggests that progressive lung scarring in the context of IPF represents a risk factor for lung carcinogenesis...
April 1, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28369217/evolutionary-adaptation-revealed-by-comparative-genome-analysis-of-woolly-mammoths-and-elephants
#15
Sean D Smith, Joseph K Kawash, Spyros Karaiskos, Ian Biluck, Andrey Grigoriev
Comparative genomics studies typically limit their focus to single nucleotide variants (SNVs) and that was the case for previous comparisons of woolly mammoth genomes. We extended the analysis to systematically identify not only SNVs but also larger structural variants (SVs) and indels and found multiple mammoth-specific deletions and duplications affecting exons or even complete genes. The most prominent SV found was an amplification of RNase L (with different copy numbers in different mammoth genomes, up to 9-fold), involved in antiviral defense and inflammasome function...
March 22, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/28368570/methanogenic-biocathode-microbial-community-development-and-the-role-of-bacteria
#16
Christy M Dykstra, Spyros G Pavlostathis
The cathode microbial community of a methanogenic bioelectrochemical system (BES) is key to the efficient conversion of carbon dioxide (CO2) to methane (CH4) with application to biogas upgrading. The objective of this study was to compare the performance and microbial community composition of a biocathode inoculated with a mixed methanogenic (MM) culture to a biocathode inoculated with an enriched hydrogenotrophic methanogenic (EHM) culture, developed from the MM culture following pre-enrichment with H2 and CO2 as the only externally supplied electron donor and carbon source, respectively...
April 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28357554/outcome-of-treatment-after-failed-endoscopic-third-ventriculostomy-etv-in-infants-with-aqueductal-stenosis-results-from-the-international-infant-hydrocephalus-study-iihs
#17
Abhaya V Kulkarni, Spyros Sgouros, Shlomi Constantini
INTRODUCTION: After an endoscopic third ventriculostomy (ETV) fails, it is unclear how well subsequent treatment fares, especially in comparison to shunts inserted as primary treatment. In this study, we present a further analysis of the infants enrolled a prospective multicentre study who failed ETV and describe the outcome of their subsequent treatment, comparing this to those who received shunt as their primary treatment. METHODS: This was a post hoc analysis of data from the International Infant Hydrocephalus Study (IIHS)-a prospective, multicentre study of infants with hydrocephalus from aqueductal stenosis who received either an ETV or shunt...
March 29, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28349511/risk-of-endometrial-cancer-in-women-treated-with-ovary-stimulating-drugs-for-subfertility
#18
REVIEW
Alkistis Skalkidou, Theodoros N Sergentanis, Spyros P Gialamas, Marios K Georgakis, Theodora Psaltopoulou, Marialena Trivella, Charalampos S Siristatidis, Evangelos Evangelou, Eleni Petridou
BACKGROUND: Medical treatment for subfertility principally involves the use of ovary-stimulating agents, including selective oestrogen receptor modulators (SERMs), such as clomiphene citrate, gonadotropins, gonadotropin-releasing hormone (GnRH) agonists and antagonists, as well as human chorionic gonadotropin. Ovary-stimulating drugs may act directly or indirectly upon the endometrium (lining of the womb). Nulliparity and some causes of subfertility are recognized as risk factors for endometrial cancer...
March 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28347959/the-impact-of-succinate-trace-on-pww0-and-ortho-cleavage-pathway-transcription-in-pseudomonas-putida-mt-2-during-toluene-biodegradation
#19
Argyro Tsipa, Michalis Koutinas, Spyros I Vernardis, Athanasios Mantalaris
Toluene is a pollutant catabolised through the interconnected pWW0 (TOL) and ortho-cleavage pathways of Pseudomonas putida mt-2, while upon succinate and toluene mixtures introduction in batch cultures grown on M9 medium, succinate was previously reported as non-repressing. The effect of a 40 times lower succinate concentration, as compared to literature values, was explored through systematic real-time qPCR monitoring of transcriptional kinetics of the key TOL Pu, Pm and ortho-cleavage PbenR, PbenA promoters in mixed-substrate experiments...
March 16, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28347418/the-application-of-human-spinal-cord-magnetic-resonance-spectroscopy-to-clinical-studies-a-review
#20
Patrik Oliver Wyss, Andreas Hock, Spyros Kollias
This article reviews the current state of magnetic resonance spectroscopy applied in the human spinal cord with respect to its clinical applications and challenges in comparison to investigations in the human brain. Results from several disease processes affecting the spinal cord are presented, and potential advantages of applying clinical MRS in their investigation are emphasized.
April 2017: Seminars in Ultrasound, CT, and MR
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