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https://www.readbyqxmd.com/read/28706923/influence-of-abo-blood-group-on-sports-performance
#1
Giuseppe Lippi, Giorgio Gandini, Gian Luca Salvagno, Spyros Skafidas, Luca Festa, Elisa Danese, Martina Montagnana, Fabian Sanchis-Gomar, Cantor Tarperi, Federico Schena
BACKGROUND: Despite being a recessive trait, the O blood group is the most frequent worldwide among the ABO blood types. Since running performance has been recognized as a major driver of evolutionary advantage in humans, we planned a study to investigate whether the ABO blood group may have an influence on endurance running performance in middle-aged recreational athletes. METHODS: The study population consisted of 52 recreational, middle-aged, Caucasian athletes (mean age: 49±13 years, body mass index, 23...
June 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28706727/pd_manager-an-mhealth-platform-for-parkinson-s-disease-patient-management
#2
Kostas M Tsiouris, Dimitrios Gatsios, George Rigas, Dragana Miljkovic, Barbara Koroušić Seljak, Marko Bohanec, Maria T Arredondo, Angelo Antonini, Spyros Konitsiotis, Dimitrios D Koutsouris, Dimitrios I Fotiadis
PD_Manager is a mobile health platform designed to cover most of the aspects regarding the management of Parkinson's disease (PD) in a holistic approach. Patients are unobtrusively monitored using commercial wrist and insole sensors paired with a smartphone, to automatically estimate the severity of most of the PD motor symptoms. Besides motor symptoms monitoring, the patient's mobile application also provides various non-motor self-evaluation tests for assessing cognition, mood and nutrition to motivate them in becoming more active in managing their disease...
June 2017: Healthcare Technology Letters
https://www.readbyqxmd.com/read/28698090/the-superior-frontal-transsulcal-approach-to-the-anterior-ventricular-system-exploring-the-sulcal-and-subcortical-anatomy-using-anatomic-dissections-and-dti-tractography
#3
Christos Koutsarnakis, Faidon Liakos, Aristotelis V Kalyvas, Georgios P Skandalakis, Spyros Komaitis, Fotini Christidi, Efstratios Karavasilis, Evangellia Liouta, George Stranjalis
OBJECTIVE: To explore the superior frontal sulcus morphology, trajectory of the applied surgical corridor and white matter bundles that are traversed during the superior frontal transsulcal transventricular approach METHODS: Twenty (20) normal, adult, formalin-fixed cerebral hemispheres and two (2) cadaveric heads were included in the study. The superior frontal sulcus (SFS) topography, morphology and dimensions were recorded in all specimens. Fourteen (14) hemispheres were investigated through the fiber dissection technique while the remaining six (6) were explored using coronal cuts...
July 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28685492/role-of-intramuscular-levofolinate-administration-in%C3%A2-the%C3%A2-treatment-of-hereditary-folate-malabsorption-report-of-three-cases
#4
Emanuela Manea, Paul Gissen, Simon Pope, Simon J Heales, Spyros Batzios
Hereditary folate malabsorption is a rare autosomal recessive disorder caused by impaired active folate transport across membranes and into the central nervous system due to loss-of-function mutations in proton-coupled folate transporter (PCFT). Newborns with this condition have initially normal folate stores, but as they are unable to absorb dietary folate and use rapidly their stores because of their growth demands, symptoms appear in the early infancy. Significant neurological morbidity usually follows the initial non-specific clinical presentation and delayed initiation of treatment...
July 7, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28684976/use-of-costic-acid-a-natural-extract-from-dittrichia-viscosa-for-the-control-of-varroa-destructor-a-parasite-of-the-european-honey-bee
#5
Kalliopi Sofou, Demosthenis Isaakidis, Apostolos Spyros, Anita Büttner, Athanassios Giannis, Haralambos E Katerinopoulos
Costic acid has been isolated from the plant Dittrichia viscosa and its efficacy against Varroa destructor, a parasite of Apis mellifera, the European honey bee, has been studied. Costic acid exhibited potent in vivo acaricidal activity against the parasite. Initial experiments showed that the compound is not toxic for human umbilical vein endothelial cells (HUVEC) at concentrations of up to 230 micromolar (μM), indicating that costic acid could be used as a safe, low-cost and efficient agent for controlling varroosis in honey bee colonies...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28678776/crystal-structures-of-agonist-bound-human-cannabinoid-receptor-cb1
#6
Tian Hua, Kiran Vemuri, Spyros P Nikas, Robert B Laprairie, Yiran Wu, Lu Qu, Mengchen Pu, Anisha Korde, Shan Jiang, Jo-Hao Ho, Gye Won Han, Kang Ding, Xuanxuan Li, Haiguang Liu, Michael A Hanson, Suwen Zhao, Laura M Bohn, Alexandros Makriyannis, Raymond C Stevens, Zhi-Jie Liu
The cannabinoid receptor 1 (CB1) is the principal target of the psychoactive constituent of marijuana, the partial agonist Δ(9)-tetrahydrocannabinol (Δ(9)-THC). Here we report two agonist-bound crystal structures of human CB1 in complex with a tetrahydrocannabinol (AM11542) and a hexahydrocannabinol (AM841) at 2.80 Å and 2.95 Å resolution, respectively. The two CB1-agonist complexes reveal important conformational changes in the overall structure, relative to the antagonist-bound state, including a 53% reduction in the volume of the ligand-binding pocket and an increase in the surface area of the G-protein-binding region...
July 5, 2017: Nature
https://www.readbyqxmd.com/read/28677397/c1-azacycloalkyl-hexahydrocannabinols
#7
Thanh C Ho, Naoyuki Shimada, Marcus A Tius, Spyros P Nikas, Wen Zhang, Alexandros Makriyannis
We report the design, synthesis, and biological evaluation of a novel class of cannabinergic ligands namely C1'-azacycloalkyl hexahydrocannabinols. Our synthetic approaches utilize an advanced common chiral intermediate triflate from which all analogs could be derived. Key synthetic steps involve microwave assisted Liebeskind-Srogl C-C cross-coupling and palladium-catalyzed decarboxylative coupling reactions. The C1'-N-methyl-azetidinyl- and C1'-N-methyl-pyrrolidinyl-analogs were found to be high affinity ligands for the CB1 and CB2 cannabinoid receptors...
July 5, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28666479/desert-dust-outbreaks-and-respiratory-morbidity-in-athens-greece
#8
Stavroula-Myrto Trianti, Evangelia Samoli, Sophia Rodopoulou, Klea Katsouyanni, Spyros A Papiris, Anna Karakatsani
BACKGROUND: Ambient particulate matter (PM) has an adverse effect on respiratory morbidity. Desert dust outbreaks contribute to increased PM levels but the toxicity of desert dust mixed with anthropogenic pollutants needs clarification. METHODS: We identified 132 days with desert dust episodes and 177 matched days by day of the week, season, temperature and humidity between 2001 and 2006 in Athens, Greece. We collected data on regulated pollutants and daily emergency outpatient visits and admissions for respiratory causes...
July 1, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28659922/a-poly-lactic-co-glycolic-acid-nanovaccine-based-on-chimeric-peptides-from-different-leishmania-infantum-proteins-induces-dendritic-cells-maturation-and-promotes-peptide-specific-ifn%C3%AE-producing-cd8-t-cells-essential-for-the-protection-against-experimental-visceral
#9
Evita Athanasiou, Maria Agallou, Spyros Tastsoglou, Olga Kammona, Artemis Hatzigeorgiou, Costas Kiparissides, Evdokia Karagouni
Visceral leishmaniasis, caused by Leishmania (L.) donovani and L. infantum protozoan parasites, can provoke overwhelming and protracted epidemics, with high case-fatality rates. An effective vaccine against the disease must rely on the generation of a strong and long-lasting T cell immunity, mediated by CD4(+) TH1 and CD8(+) T cells. Multi-epitope peptide-based vaccine development is manifesting as the new era of vaccination strategies against Leishmania infection. In this study, we designed chimeric peptides containing HLA-restricted epitopes from three immunogenic L...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28659858/biometric-digital-health-technology-for-measuring-motor-function-in-parkinson-s-disease-results-from-a-feasibility-and-patient-satisfaction-study
#10
Georgia Mitsi, Enrique Urrea Mendoza, Benjamin D Wissel, Elena Barbopoulou, Alok K Dwivedi, Ioannis Tsoulos, Athanassios Stavrakoudis, Alberto J Espay, Spyros Papapetropoulos
OBJECTIVES: To assess the feasibility, predictive value, and user satisfaction of objectively quantifying motor function in Parkinson's disease (PD) through a tablet-based application (iMotor) using self-administered tests. METHODS: PD and healthy controls (HCs) performed finger tapping, hand pronation-supination and reaction time tasks using the iMotor application. RESULTS: Thirty-eight participants (19 with PD and 17 HCs) were recruited in the study...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28646455/human-nucleus-pulposus-intervertebral-disc-cells-becoming-senescent-using-different-treatments-exhibit-a-similar-transcriptional-profile-of-catabolic-and-inflammatory-genes
#11
Sotiris-Spyros Vamvakas, Eleni Mavrogonatou, Dimitris Kletsas
PURPOSE: Chronic low back pain has been associated with intervertebral disc (IVD) degeneration, which is characterized by the accumulation of extracellular matrix (ECM)-degrading proteases and inflammatory molecules in the degenerate tissue. IVD degeneration could be the outcome of natural organismal ageing and/or of the exposure of the disc to cumulative stressful environmental stimuli and is accompanied by an increased population of senescent cells in the tissue. On the other hand, senescent cells are known to secrete proteolytic enzymes and inflammatory molecules, which can contribute to ECM catabolism...
June 23, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28644379/physical-forces-may-cause-the-hoxd-gene-cluster-elongation
#12
Spyros Papageorgiou
Hox gene collinearity was discovered be Edward B. Lewis in 1978. It consists of the Hox1, Hox2, Hox3 ordering of the Hox genes in the chromosome from the telomeric to the centromeric side of the chromosome. Surprisingly, the spatial activation of the Hox genes in the ontogenetic units of the embryo follows the same ordering along the anterior-posterior embryonic axis. The chromosome microscale differs from the embryo macroscale by 3 to 4 orders of magnitude. The traditional biomolecular mechanisms are not adequate to comprise phenomena at so divergent spatial domains...
June 23, 2017: Biology
https://www.readbyqxmd.com/read/28628993/the-impact-of-silver-nanoparticles-on-marine-plankton-dynamics-dependence-on-coating-size-and-concentration
#13
Anastasia Tsiola, Paraskevi Pitta, Agnès Junyer Callol, Margarita Kagiorgi, Ioanna Kalantzi, Kyriaki Mylona, Ioulia Santi, Claudio Toncelli, Spyros Pergantis, Manolis Tsapakis
During this study, three microcosm experiments were carried out with natural coastal seawater, collected in the Eastern Mediterranean Sea, in order to assess the effect of silver nanoparticle (AgNP) exposure to natural plankton communities. The impact of coating (branched-polyethyleneimine: BPEI vs. poly-vinylpyrrolidone: PVP), size (40 vs. 60nm), concentration (200, 500, 2000, 5000 and 10,000ng Ag L(-1)) and silver form (dissolved Ag(+) vs. AgNPs) were tested. The results of chlorophyll a concentration revealed that PVP AgNPs caused a higher toxicity than BPEI AgNPs, and this was possibly related to the measured higher dissolution rate...
June 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28627547/probing-the-electronic-structure-of-a-copper-ii-complex-by-cw-and-pulse-epr-spectroscopy
#14
Zoi G Lada, Yiannis Sanakis, Catherine P Raptopoulou, Vassilis Psycharis, Spyros P Perlepes, George Mitrikas
Nucleophilic attack by the carbanion (-):CH2COCH3 at the carbonyl group of di-2-pyridyl ketone, (py)2CO, in the presence of Cu(II) under moderately basic conditions has yielded the cationic mononuclear complex [Cu{(py)2C(CH2COCH3)(OH)}2](NO3)2·2H2O (1·2H2O) in ∼40% yield, where (py)2C(CH2COCH3)(OH) is the ligand bis(2-pyridine-2-yl)butane-1-ol-3-one. The Cu(II) atom of the cation sits on a crystallographically imposed inversion center. The neutral molecule is coordinated to the metal ion as a tridentate fac chelating ligand through the hydroxyl oxygen atom and two 2-pyridyl nitrogen atoms...
June 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28623062/salvage-of-the-foot-for-recurrent-malignant-peripheral-nerve-sheath%C3%A2-tumor
#15
Meletis Rozis, Eustratios Papadelis, Andreas Mavrogenis, Spyridon Koufos, Vasilios Polyzois, Spyros Pneumaticos
Malignant peripheral nerve sheath tumors are rare soft tissue tumors accounting for 3% to 10% of all soft tissue tumors. They are strongly related to neurofibromatosis type 1, an autosomal dominant disease, and are characterized by aggressive biologic behavior, high local recurrence rates, and frequent metastases. Although the major nerves of the lower extremities are a common location of these tumors, scarce cases have been reported of malignant peripheral nerve sheath tumors involving the interdigital nerves of the foot...
June 13, 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28622419/the-risk-of-hepatocellular-carcinoma-is-decreasing-after-the-first-5-years-of-entecavir-or-tenofovir-in-caucasians-with-chronic-hepatitis-b
#16
George V Papatheodoridis, Ramazan Idilman, George N Dalekos, Maria Buti, Heng Chi, Florian van Boemmel, Jose Luis Calleja, Vana Sypsa, John Goulis, Spilios Manolakopoulos, Alessandro Loglio, Spyros Siakavelas, Onur Keskın, Nikolaos Gatselis, Bettina E Hansen, Maria Lehretz, Juan de la Revilla, Savvoula Savvidou, Anastasia Kourikou, Ioannis Vlachogiannakos, Kostantinos Galanis, Cihan Yurdaydin, Thomas Berg, Massimo Colombo, Rafael Esteban, Harry L A Janssen, Pietro Lampertico
Whether there is a change of hepatocellular carcinoma (HCC) incidence in chronic hepatitis B (CHB) patients under long-term therapy with potent nucleos(t)ide analogues is currently unclear. We therefore assessed the HCC incidence beyond year 5 of entecavir/tenofovir therapy and tried to determine possible factors associated with late HCC occurrence. This European 10-center, cohort study included 1951 adult Caucasian CHB patients without HCC at baseline who received entecavir/tenofovir for ≥1 year. Of them, 1205 (62%) patients without HCC within the first 5 years of therapy have been followed for 5-10 (median: 6...
June 16, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28621372/molecular-dynamics-simulation-of-the-local-concentration-and-structure-in-multicomponent-aerosol-nanoparticles-under-atmospheric-conditions
#17
Katerina S Karadima, Vlasis G Mavrantzas, Spyros N Pandis
Molecular dynamics (MD) simulations were employed to investigate the local structure and local concentration in atmospheric nanoparticles consisting of an organic compound (cis-pinonic acid or n-C30H62), sulfate and ammonium ions, and water. Simulations in the isothermal-isobaric (NPT) statistical ensemble under atmospheric conditions with a prespecified number of molecules of the abovementioned compounds led to the formation of a nanoparticle. Calculations of the density profiles of all the chemical species in the nanoparticle, the corresponding radial pair distribution functions, and their mobility inside the nanoparticle revealed strong interactions developing between sulfate and ammonium ions...
June 28, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28611262/relative-adrenal-insufficiency-is-associated-with-the-clinical-outcome-in-patients-with-stable-decompensated-cirrhosis
#18
Evangelos Cholongitas, Ioannis Goulis, Eirini Pagkalidou, Anna Haidich, Apostolos Karagiannis, Theodora Nakouti, Chrysoula Pipili, Theodora Oikonomou, Spyros Gerou, Evangelos Akriviadis
BACKGROUND: The clinical impact of relative adrenal insufficiency (AI) on patients with stable decompensated cirrhosis (DeCi) has not been yet elucidated. AIM: Explore the association between AI and outcome [death or liver transplantation (LT)] in patients with DeCi. MATERIAL AND METHODS: Patients with DeCi presenting no active complication have been included. Clinical and laboratory data, including serum levels of corticosteroid-binding globulin (CBG), interleukin (IL)-1b, IL-6 and tumor necrosis factor (TNFα) were recorded in each participant...
August 1, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28605445/evaluation-of-two-automated-systems-for-colistin-susceptibility-testing-of-carbapenem-resistant-acinetobacter-baumannii-clinical-isolates
#19
Sophia Vourli, Konstantina Dafopoulou, Georgia Vrioni, Athanassios Tsakris, Spyros Pournaras
Background: Colistin is commonly needed for the treatment of infections due to carbapenem-resistant Acinetobacter baumannii (CRAB) and the determination of its in vitro activity is obviously important. However, the accurate routine antimicrobial susceptibility testing (AST) of colistin is still challenging. The only acceptable method for colistin AST is broth microdilution (BMD); disc and gradient diffusion assays are inappropriate and the performance of semi-automated systems has not been validated...
June 12, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28605206/the-effect-of-a-holistic-self-management-plan-on-asthma-control
#20
Eirini Grammatopoulou, Emmanouil K Skordilis, Aikaterini Haniotou, Zarotis John, Spyros Athanasopoulos
The holistic self-management plan includes lifelong actions that enable patients to cope with their disease. The present study was designed to evaluate the effect of a holistic self-management plan on asthma control. A 12-month controlled study was conducted. Adult patients with mild-to-moderate asthma (n = 24) who attended the emergency asthma department were randomized to two groups: One group followed four educational sessions and three personal home sessions (n = 12), while a second group received a short manual with asthma information (n = 12)...
June 12, 2017: Physiotherapy Theory and Practice
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