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https://www.readbyqxmd.com/read/29156006/diana-tarbase-v8-a-decade-long-collection-of-experimentally-supported-mirna-gene-interactions
#1
Dimitra Karagkouni, Maria D Paraskevopoulou, Serafeim Chatzopoulos, Ioannis S Vlachos, Spyros Tastsoglou, Ilias Kanellos, Dimitris Papadimitriou, Ioannis Kavakiotis, Sofia Maniou, Giorgos Skoufos, Thanasis Vergoulis, Theodore Dalamagas, Artemis G Hatzigeorgiou
DIANA-TarBase v8 (http://www.microrna.gr/tarbase) is a reference database devoted to the indexing of experimentally supported microRNA (miRNA) targets. Its eighth version is the first database indexing >1 million entries, corresponding to ∼670 000 unique miRNA-target pairs. The interactions are supported by >33 experimental methodologies, applied to ∼600 cell types/tissues under ∼451 experimental conditions. It integrates information on cell-type specific miRNA-gene regulation, while hundreds of thousands of miRNA-binding locations are reported...
November 16, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29151998/hallux-osteoid-osteoma-a-case-report-and-literature-review
#2
REVIEW
Konstantinos C Xarchas, George Kyriakopoulos, Spyros Manthas, Leon Oikonomou
Osteoid osteoma is a benign bone tumour that mostly affects males in the second and third decade of their life. The lesion mainly occurs in long bones, usually in the femur and tibia, causing severe localized pain that is worse at night and responds to nonsteroidal anti-inflammatory drugs (NSAIDs). Diagnosis is usually made on the basis of history and radiographic findings. However, in more unusual locations as the hand and foot, diagnostic issues can arise. Treatment often includes complete removal of the tumor...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/29151692/fecal-calprotectin-measurement-is-a-marker-of-short-term-clinical-outcome-and-presence-of-mucosal-healing-in-patients-with-inflammatory-bowel-disease
#3
Athanasios Kostas, Spyros I Siakavellas, Charalambos Kosmidis, Anna Takou, Joanna Nikou, Georgios Maropoulos, John Vlachogiannakos, George V Papatheodoridis, Ioannis Papaconstantinou, Giorgos Bamias
AIM: To evaluate the utility of fecal calprotectin (FC) in predicting relapse and endoscopic activity during follow-up in an inflammatory bowel disease (IBD) cohort. METHODS: All FC measurements that were obtained during a 3-year period from patients with inflammatory bowel disease in clinical remission were identified. Data regarding the short-term (6 mo) course of the disease were extracted from the medical files. Exclusion criteria were defined as: (1) An established flare of the disease at the time of FC measurement, (2) Loss to follow up within 6 mo from baseline FC measurement, and, (3) Insufficient data on file...
November 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29129457/acute-effects-of-graduated-elastic-compression-stockings-in-patients-with-symptomatic-varicose-veins-a-randomised-double-blind-placebo-controlled-trial
#4
Stavros K Kakkos, Marios Timpilis, Panayiotis Patrinos, Konstantinos M Nikolakopoulos, Chrysanthi P Papageorgopoulou, Anastasia K Kouri, Ioannis Ntouvas, Spyros I Papadoulas, George C Lampropoulos, Ioannis A Tsolakis
OBJECTIVES: To investigate the effectiveness of graduated elastic compression stockings (GECS) below the knee in improving symptoms in patients with varicose veins in the absence of high quality evidence. METHODS: This was a randomised double blind placebo controlled trial. Thirty patients with no experience of elastic stockings, presenting with primary varicose veins causing calf pain or aching were randomised to a GECS (18-21 mmHg at the ankle level, n=15) or a placebo stocking (0 mmHg, n=15)...
November 10, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29117591/effects-of-salinity-and-cod-n-on-denitrification-and-bacterial-community-in-dicyclic-type-electrode-based-biofilm-reactor
#5
Siyuan Zhai, Min Ji, Yingxin Zhao, Spyros G Pavlostathis, Qing Zhao
A dicyclic-type electrode based biofilm electrode reactor (BER) was developed for advanced nitrate removal from saline municipal wastewater. The denitrification efficiency was evaluated with a synthetic feed (NO3(-)-N, 20 mg L(-1)) under different salinity and COD to nitrogen ratios (COD/N). As the salinity increased from 0% to 1.0%, the denitrification performance of both the traditional biofilm reactor (BR) and BER was inhibited; however, the BER showed better adaptation and ability to recover. The BER achieved a high nitrate removal efficiency (≥90%) at a salinity of 1...
October 23, 2017: Chemosphere
https://www.readbyqxmd.com/read/29099646/emphysematous-phenotype-is-characterized-by-low-blood-eosinophils-a-cross-sectional-study
#6
Andriana I Papaioannou, Konstantinos Kostikas, Anastasia Papaporfyriou, Leonidas Angelakis, Evgenia Papathanasiou, Georgios Hillas, Argyro Mazioti, Petros Bakakos, Nikolaos Koulouris, Spyros Papiris, Stelios Loukides
Sputum and blood eosinophils are proposed as candidate biomarkers for the identification of chronic obstructive pulmonary disease (COPD) patients at risk for exacerbation and treatment response. In this study, we evaluated the associations of eosinophils with the presence of emphysema in COPD patients. Induced sputum and blood eosinophil measurements were performed in consecutive COPD patients. Patients underwent lung function testing and high resolution computed tomography (HRCT) of the chest and the presence of emphysema was quantified...
November 3, 2017: COPD
https://www.readbyqxmd.com/read/29091775/single-cell-rna-seq-analysis-of-infiltrating-neoplastic-cells-at-the-migrating-front-of-human-glioblastoma
#7
Spyros Darmanis, Steven A Sloan, Derek Croote, Marco Mignardi, Sophia Chernikova, Peyman Samghababi, Ye Zhang, Norma Neff, Mark Kowarsky, Christine Caneda, Gordon Li, Steven D Chang, Ian David Connolly, Yingmei Li, Ben A Barres, Melanie Hayden Gephart, Stephen R Quake
Glioblastoma (GBM) is the most common primary brain cancer in adults and is notoriously difficult to treat because of its diffuse nature. We performed single-cell RNA sequencing (RNA-seq) on 3,589 cells in a cohort of four patients. We obtained cells from the tumor core as well as surrounding peripheral tissue. Our analysis revealed cellular variation in the tumor's genome and transcriptome. We were also able to identify infiltrating neoplastic cells in regions peripheral to the core lesions. Despite the existence of significant heterogeneity among neoplastic cells, we found that infiltrating GBM cells share a consistent gene signature between patients, suggesting a common mechanism of infiltration...
October 31, 2017: Cell Reports
https://www.readbyqxmd.com/read/29081745/changes-of-functional-and-directed-resting-state-connectivity-are-associated-with-neuronal-oscillations-apoe-genotype-and-amyloid-deposition-in-mild-cognitive-impairment
#8
Lars Michels, Muthuraman Muthuraman, Abdul R Anwar, Spyros Kollias, Sandra E Leh, Florian Riese, Paul G Unschuld, Michael Siniatchkin, Anton F Gietl, Christoph Hock
The assessment of effects associated with cognitive impairment using electroencephalography (EEG) power mapping allows the visualization of frequency-band specific local changes in oscillatory activity. In contrast, measures of coherence and dynamic source synchronization allow for the study of functional and effective connectivity, respectively. Yet, these measures have rarely been assessed in parallel in the context of mild cognitive impairment (MCI) and furthermore it has not been examined if they are related to risk factors of Alzheimer's disease (AD) such as amyloid deposition and apolipoprotein ε4 (ApoE) allele occurrence...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29055751/post-cardiac-arrest-syndrome-pathological-processes-biomarkers-and-vasopressor-support-and-potential-therapeutic-targets
#9
EDITORIAL
Spyros D Mentzelopoulos, Spyros G Zakynthinos
No abstract text is available yet for this article.
October 18, 2017: Resuscitation
https://www.readbyqxmd.com/read/29040163/adipose-tissue-is-enriched-for-activated-and-late-differentiated-cd8-t-cells-and-shows-distinct-cd8-receptor-usage-compared-to-blood-in-hiv-infected-persons
#10
John R Koethe, Wyatt McDonnell, Arion Kennedy, Chike O Abana, Mark Pilkinton, Ian Setliff, Ivelin Georgiev, Louise Barnett, Cindy C Hager, Rita Smith, Spyros A Kalams, Alyssa Hasty, Simon Mallal
BACKGROUND: Adverse viral and medication effects on adipose tissue contribute to the development of metabolic disease in HIV-infected persons, but T cells also have a central role modulating local inflammation and adipocyte function. We sought to characterize potentially pro-inflammatory T cell populations in adipose tissue among persons on long-term antiretroviral therapy, and assess whether adipose tissue CD8 T cells represent an expanded, oligoclonal population. METHODS: We recruited 10 HIV-infected, overweight and obese adults on efavirenz, tenofovir, and emtricitabine for >4 years with consistent viral suppression...
October 14, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28994592/zero-valent-iron-enhances-biocathodic-carbon-dioxide-reduction-to-methane
#11
Christy M Dykstra, Spyros G Pavlostathis
Methanogenic bioelectrochemical systems (BESs), which convert carbon dioxide (CO2) directly to methane (CH4), promise to be an innovative technology for anaerobic digester biogas upgrading. Zero-valent iron (ZVI), which has previously been used to improve CH4 production in anaerobic digesters, has not been explored in methanogenic biocathodes. Thus, the objective of this study was to assess the effect of biocathode ZVI on BES performance at 1 and 2 g/L initial ZVI concentrations and at various cathode potentials (-0...
November 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28972094/cytomegalovirus-cmv-epitope-specific-cd4-t-cells-are-inflated-in-hiv-cmv-subjects
#12
Chike O Abana, Mark A Pilkinton, Silvana Gaudieri, Abha Chopra, Wyatt J McDonnell, Celestine Wanjalla, Louise Barnett, Rama Gangula, Cindy Hager, Dae K Jung, Brian G Engelhardt, Madan H Jagasia, Paul Klenerman, Elizabeth J Phillips, David M Koelle, Spyros A Kalams, Simon A Mallal
Select CMV epitopes drive life-long CD8(+) T cell memory inflation, but the extent of CD4 memory inflation is poorly studied. CD4(+) T cells specific for human CMV (HCMV) are elevated in HIV(+) HCMV(+) subjects. To determine whether HCMV epitope-specific CD4(+) T cell memory inflation occurs during HIV infection, we used HLA-DR7 (DRB1*07:01) tetramers loaded with the glycoprotein B DYSNTHSTRYV (DYS) epitope to characterize circulating CD4(+) T cells in coinfected HLA-DR7(+) long-term nonprogressor HIV subjects with undetectable HCMV plasma viremia...
November 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28971432/cognitive-enhancement-using-ict-and-its-ethical-implications
#13
Spyros Doukakis, Giannis Stamatellos, Nektaria Glinou
The utilization of digital tools aiming at the cognitive enhancement of students and adults, so that they can achieve better performance and professional or academic success, has increased in recent years. This paper focuses on ICT tools such as computer games, programming languages and educational software as means for cognitive enhancement and attempts to highlight their contributions. Issues of design and the limitations of digital tools are discussed. In the final section, the ethical implications of using educational ICT tools for cognitive enhancement from a virtue ethics perspective are presented...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28971429/bullying-in-virtual-learning-communities
#14
Stefanos Nikiforos, Spyros Tzanavaris, Katia Lida Kermanidis
Bullying through the internet has been investigated and analyzed mainly in the field of social media. In this paper, it is attempted to analyze bullying in the Virtual Learning Communities using Natural Language Processing (NLP) techniques, mainly in the context of sociocultural learning theories. Therefore four case studies took place. We aim to apply NLP techniques to speech analysis on communication data of online communities. Emphasis is given on qualitative data, taking into account the subjectivity of the collaborative activity...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28971401/persubs-a-graph-based-algorithm-for-the-identification-of-perturbed-subpathways-caused-by-complex-diseases
#15
Aristidis G Vrahatis, Angeliki Rapti, Spyros Sioutas, Athanasios Tsakalidis
In the era of Systems Biology and growing flow of omics experimental data from high throughput techniques, experimentalists are in need of more precise pathway-based tools to unravel the inherent complexity of diseases and biological processes. Subpathway-based approaches are the emerging generation of pathway-based analysis elucidating the biological mechanisms under the perspective of local topologies onto a complex pathway network. Towards this orientation, we developed PerSub, a graph-based algorithm which detects subpathways perturbed by a complex disease...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28949988/generation-of-an-immortalized-mesenchymal-stem-cell-line-producing-a-secreted-biosensor-protein-for-glucose-monitoring
#16
Evangelia K Siska, Itamar Weisman, Jacob Romano, Zoltán Ivics, Zsuzsanna Izsvák, Uriel Barkai, Spyros Petrakis, George Koliakos
Diabetes is a chronic disease characterized by high levels of blood glucose. Diabetic patients should normalize these levels in order to avoid short and long term clinical complications. Presently, blood glucose monitoring is dependent on frequent finger pricking and enzyme based systems that analyze the drawn blood. Continuous blood glucose monitors are already on market but suffer from technical problems, inaccuracy and short operation time. A novel approach for continuous glucose monitoring is the development of implantable cell-based biosensors that emit light signals corresponding to glucose concentrations...
2017: PloS One
https://www.readbyqxmd.com/read/28947487/cannabinoid-cb1-discrimination-effects-of-endocannabinoids-and-catabolic-enzyme-inhibitors
#17
Michael Z Leonard, Shakiru O Alapafuja, Lipin Ji, Vidyanand G Shukla, Yingpeng Liu, Spyros P Nikas, Alexandros Makriyannis, Jack Bergman, Brian D Kangas
An improved understanding of the endocannabinoid system has provided new avenues of drug discovery and development toward the management of pain and other behavioral maladies. Exogenous cannabinoid type 1 (CB1) receptor agonists such as Δ(9)-tetrahydrocannabinol are increasingly used for their medicinal actions; however, their utility is constrained by concern regarding abuse-related subjective effects. This has led to growing interest in the clinical benefit of indirectly enhancing the activity of the highly labile endocannabinoids N-arachidonoylethanolamine [AEA (or anandamide)] and/or 2-arachidonoylglycerol (2-AG) via catabolic enzyme inhibition...
December 2017: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/28943087/stomatal-opening-involves-polar-not-radial-stiffening-of-guard-cells
#18
Ross Carter, Hugh Woolfenden, Alice Baillie, Sam Amsbury, Sarah Carroll, Eleanor Healicon, Spyros Sovatzoglou, Sioban Braybrook, Julie E Gray, Jamie Hobbs, Richard J Morris, Andrew J Fleming
It has long been accepted that differential radial thickening of guard cells plays an important role in the turgor-driven shape changes required for stomatal pore opening to occur [1-4]. This textbook description derives from an original interpretation of structure rather than measurement of mechanical properties. Here we show, using atomic force microscopy, that although mature guard cells display a radial gradient of stiffness, this is not present in immature guard cells, yet young stomata show a normal opening response...
October 9, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28935908/biometric-monitoring-devices-for-assessing-end-points-in-clinical-trials-developing-an-ecosystem
#19
Stephen P Arnerić, Jesse M Cedarbaum, Sean Khozin, Spyros Papapetropoulos, Derek L Hill, Michael Ropacki, Jane Rhodes, Penny A Dacks, Lynn D Hudson, Mark Forrest Gordon, Volker D Kern, Klaus Romero, George Vradenburg, Rhoda Au, Daniel R Karlin, Maurizio F Facheris, Cheryl J Fitzer-Attas, Ottavio V Vitolo, Jian Wang, Bradley M Miller, Jeffrey A Kaye
No abstract text is available yet for this article.
September 22, 2017: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/28926162/retinal-vessel-morphology-in-rheumatoid-arthritis-association-with-systemic-inflammation-subclinical-atherosclerosis-and-cardiovascular-risk
#20
Panagiota Anyfanti, Areti Triantafyllou, Eugenia Gkaliagkousi, Nikolaos Koletsos, Georgios Athanasopoulos, Xenophon Zabulis, Vasiliki Galanopoulou, Spyros Aslanidis, Stella Douma
OBJECTIVE: Quantification of retinal vessel morphology has emerged as a marker of cardiovascular health. We examined retinal microvascular diameters in RA, particularly in regard with systemic inflammation, subclinical atherosclerosis and cardiovascular risk. METHODS: Retinal images from RA patients and controls were processed using computerized software, to obtain central retinal arteriolar (CRAE) and venular (CRVE) equivalent and arteriovenous ratio (AVR). Subclinical atherosclerosis was assessed with carotid intima-media thickness (cIMT), and 10-year risk of general cardiovascular disease was calculated...
September 19, 2017: Microcirculation: the Official Journal of the Microcirculatory Society, Inc
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