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https://www.readbyqxmd.com/read/29344218/atra-increases-iodine-uptake-and-inhibits-the-proliferation-and-invasiveness-of-human-anaplastic-thyroid-carcinoma-sw1736-cells-involvement-of-%C3%AE-catenin-phosphorylation-inhibition
#1
Ling Lan, Spyros Basourakos, Dai Cui, Xuemei Zuo, Wei Deng, Lili Huo, Hailing Chen, Guoying Zhang, Lili Deng, Bingyin Shi, Yong Luo
All-trans-retinoic acid (ATRA) can enhance iodine uptake capability of thyroid tumors, but the mechanisms remain poorly understood. The aim of the present study was to investigate the effects of ATRA on isotope susceptibility, proliferation and invasion of anaplastic thyroid carcinoma (ATC) and potential mechanisms. SW1736 cells were treated with 1 µmol/l ATRA or 1% ethanol for 5 days. A cell line stably expressing β-catenin-shRNA was established. An iodine uptake assay was performed using 125I. Proliferation and invasiveness were tested using MTT and Transwell assays, respectively...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29334161/the-role-of-neurosonology-in-the-diagnosis-and-management-of-patients-with-carotid-artery-disease-a-review
#2
REVIEW
Odysseas Kargiotis, Apostolos Safouris, Georgios Magoufis, Maria Georgala, Andromachi Roussopoulou, Eleftherios Stamboulis, Konstantinos G Moulakakis, Andreas Lazaris, George Geroulakos, Spyros Vasdekis, Georgios Tsivgoulis
Carotid artery disease (CAD) is a common cause of ischemic stroke with high rates of recurrence. Carotid endarterectomy (CEA) or carotid artery stenting (CAS) are highly recommended for the secondary prevention of symptomatic CAD during the first 14 days following the index event of transient ischemic attack or minor stroke. CEA or CAS may also be offered in selected cases with severe asymptomatic stenosis. Herein, we review the utility of neurosonology in the diagnosis and pre-/peri-interventional assessment of CAD patients who undergo carotid revascularization procedures...
January 15, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29333074/laparoendoscopic-rendezvous-may-be-an-effective-alternative-to-a-failed-preoperative-endoscopic-retrograde-cholangiopancreatography-in-patients-with-cholecystocholedocholithiasis
#3
Fotios Tsiopoulos, Andreas Kapsoritakis, Athanassios Psychos, Anastasios Manolakis, Konstantinos Oikonomou, George Tzovaras, Ioannis Baloyiannis, Alexandra Tsikrika, Spyros Potamianos
Background: Endoscopic retrograde cholangiopancreatography (ERCP), followed by laparoscopic cholecystectomy (LC), remains the standard way of management for patients with cholecystocholedocholithiasis. Laparoendoscopic rendezvous (LERV), a combined procedure for removing the gallbladder laparoscopically and clearing the common bile duct (CBD) endoscopically at the same time, could be an attractive alternative. The aim of this study was to compare LERV with classic ERCP in patients with cholecystocholedocholithiasis...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29329486/cost-effectiveness-of-guided-internet-based-interventions-for-depression-in-comparison-with-control-conditions-an-individual-participant-data-meta-analysis
#4
REVIEW
Spyros Kolovos, Johanna M van Dongen, Heleen Riper, Claudia Buntrock, Pim Cuijpers, David D Ebert, Anna S Geraedts, Robin M Kenter, Stephanie Nobis, Andrea Smith, Lisanne Warmerdam, Jill A Hayden, Maurits W van Tulder, Judith E Bosmans
BACKGROUND: There is limited evidence on the cost effectiveness of Internet-based treatments for depression. The aim was to evaluate the cost effectiveness of guided Internet-based interventions for depression compared to controls. METHODS: Individual-participant data from five randomized controlled trials (RCT), including 1,426 participants, were combined. Cost-effectiveness analyses were conducted at 8 weeks, 6 months, and 12 months follow-up. RESULTS: The guided Internet-based interventions were more costly than the controls, but not statistically significant (12 months mean difference = €406, 95% CI: - 611 to 1,444)...
January 12, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29325070/vaccine-induced-antibody-responses-modify-the-association-between-t-cell-immune-responses-and-hiv-1-infection-risk-in-hvtn-505
#5
Youyi Fong, Xiaoying Shen, Vicki C Ashley, Aaron Deal, Kelly E Seaton, Chenchen Yu, Shannon P Grant, Guido Ferrari, Allan C deCamp, Robert T Bailer, Richard A Koup, David Montefiori, Barton F Haynes, Marcella Sarzotti-Kelsoe, Barney S Graham, Lindsay N Carpp, Scott M Hammer, Magda Sobieszczyk, Shelly Karuna, Edith Swann, Edwin DeJesus, Mark Mulligan, Ian Frank, Susan Buchbinder, Richard M Novak, M Juliana McElrath, Spyros Kalams, Michael Keefer, Nicole A Frahm, Holly E Janes, Peter B Gilbert, Georgia D Tomaras
Background: HVTN 505 was an HIV-1 preventive vaccine efficacy trial of a DNA/recombinant adenovirus serotype 5 (rAd5) vaccine regimen. We assessed antibody responses measured one month post-final vaccination (Month 7) as correlates of HIV-1 acquisition risk. Methods: Binding antibody responses were quantified in serum samples from 25 primary endpoint vaccine cases (diagnosed with HIV-1 infection between Month 7 and 24) and 125 randomly sampled frequency-matched vaccine controls (HIV-1 negative at Month 24)...
January 8, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29316212/renal-artery-stenting-for-atherosclerotic-renal-artery-stenosis-identified-in-patients-with-coronary-artery-disease-does-captopril-renal-scintigraphy-predict-outcomes
#6
Spyros Stratigis, Kostas Stylianou, Periklis P Kyriazis, Eleftheria-Kleio Dermitzaki, Dimitra Lygerou, Paraskevi Syngelaki, Stavros Stratakis, Sophia Koukouraki, Fragiskos Parthenakis, Dimitrios Tsetis, Eugene Daphnis
The authors evaluated the effectiveness of percutaneous renal revascularization (PRR) with stenting for the treatment of atherosclerotic renal artery stenosis (ARAS) in patients with coronary artery disease and the usefulness of captopril renal scintigraphy for predicting clinical outcomes after PRR. Sixty-four consecutive patients, referred for evaluation of suspected ARAS, after coronary angiography, underwent baseline captopril renal scintigraphy followed by renal angiography. Forty-four patients (68.7%) were diagnosed with a significant ARAS≥ 60% and were treated with PRR plus medical therapy...
January 6, 2018: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/29286656/physical-and-chemical-properties-of-3-methyl-1-2-3-butanetricarboxylic-acid-mbtca-aerosol
#7
Evangelia Kostenidou, Eleni Karnezi, Agata Kolodziejczyk, Rafal Szmigielski, Spyros Pandis
The properties and the chemical fate of later generation products of the oxidation of biogenic organic compounds are mostly unknown. The properties of fresh MBTCA aerosol, a later generation product of the oxidation of monoterpenes in the atmosphere, were determined combining an Aerosol Mass Spectrometer (AMS), a thermodenuder, and a scanning mobility particle sizer. Based on its AMS spectrum m/z 141.055 (C7H9O3+) could be used as an MBTCA signature. The MBTCA particle density was 1.43±0.04 g cm-3, its saturation concentration was (1...
December 29, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29280429/case-report-carbapenemase-producing-enterobacteriaceae-in-an-asylum-seeker-with-multidrug-resistant-tuberculosis
#8
Sofanne J Ravensbergen, Christina Louka, Mariëtte Lokate, Erik Bathoorn, Spyros Pournaras, Tjip S van der Werf, Wiel C M de Lange, Ymkje Stienstra, Onno W Akkerman
A Syrian asylum seeker with multidrug-resistant tuberculosis (TB) developed a bronchopleural fistula after pneumonectomy. Although screening tests were negative on admission, carbapenemase-producing Enterobacteriaceae were cultured after a few months of TB treatment. Prevalence of multidrug-resistant organisms is reported to be increased in asylum seekers compared with the general Dutch population. Arduous conditions during transit and interrupted health care delivery in our patient led to multiple-resistant microorganisms that complicated treatment...
December 26, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29279778/intraoperative-use-of-cbct-for-identification-and-localization-of-calcified-canals-a-clinical-technique
#9
Spyros Floratos, Maria-Elpida Miltiadous
Localization of calcified canals has always been a challenge in the field of endodontics. The following report of three cases describes a technique for the identification and negotiation of obliterated canals by use of cone beam computed tomography (CBCT) intraoperatively. Canal orifices could not be found clinically in all three cases. Gutta-percha points were placed and compacted at the position where the canal orifices were estimated to be. Intraoperative CBCT was taken, and the distance between the gutta-percha points and the canal orifices was calculated at all planes of space in the first two cases...
2017: Case Reports in Dentistry
https://www.readbyqxmd.com/read/29277688/ability-of-using-different-dry-powder-inhalers-during-copd-exacerbations
#10
Andriana I Papaioannou, Yiolanda Herodotou, Ioannis Tomos, Vasiliki Apollonatou, Galateia Verykokou, Evgenia Papathanasiou, Effrosyni D Manali, Stelios Loukides, Spyros A Papiris
BACKGROUND: Guidelines suggest that patients hospitalized for acute COPD exacerbations (AECOPD) are treated with short acting bronchodilators. Long acting bronchodilators, offer longer symptom relief but since they are usually administered via Dry Powder Inhalers (DPIs) it is considered that during AECOPD patients would not be able to achieve appropriate inspiratory flow (IF) to receive appropriate drug doses. The aim of the present study was to evaluate whether patients admitted to the hospital for AECOPD, are able to achieve the necessary IF using different DPIs...
December 19, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29277133/tinzaparin-in-intermediate-dose-for-the-treatment-of-superficial-vein-thrombosis-results-from-an-observational-multicenter-study-seven-study
#11
Athanasios Giannoukas, Christos Karathanos, Konstantinos Nikolakopoulos, Georgios Georgiadis, Chrisostomos Maltezos, Christos Ioannou, Spyros Vasdekis, Georgios Trelopoulos
Objectives Low-molecular-weight heparins are recommended in the treatment of superficial vein thrombosis but with low grade of evidence. This study was conducted to assess the treatment outcomes of acute superficial vein thrombosis with intermediate dose of Tinzaparin. Methods Retrospective analysis of records from outpatients over a period of 16 months treated in seven centers with Tinzaparin 0.5 ml (10,000 anti-Xa IU) once daily for a period that was at the treating physician's discretion. All the patients were followed up for at least 12 weeks...
January 1, 2017: Phlebology
https://www.readbyqxmd.com/read/29277041/new-insight-on-the-adsorption-capacity-of-metallogels-for-antimonite-and-antimonate-removal-from-experimental-to-theoretical-study
#12
Deng You, Xiaoye Min, Lingling Liu, Zhong Ren, Xiao Xiao, Spyros G Pavlostathis, Jinming Luo, Xubiao Luo
Development of high capacity material for antimonite (Sb(III)) and antimonate (Sb(V)) removal is the key to solving water antimony contamination. Three-dimensional Cu(II)-specific metallogels (Cu-MG), which are considered to have high density adsorption sites for antimony (Sb), were first applied to adsorb Sb(III) and Sb(V). Batch assays resulted in adsorption capacities of Cu-MG for Sb(III) and Sb(V) at 102.4 mg/g and 264.1 mg/g, respectively. In addition, the adsorption capacity for Sb(III) was up to 225...
December 16, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29240986/the-essential-elements-of-a-risk-governance-framework-for-current-and-future-nanotechnologies
#13
Vicki Stone, Martin Führ, Peter H Feindt, Hans Bouwmeester, Igor Linkov, Stefania Sabella, Finbarr Murphy, Kilian Bizer, Lang Tran, Marlene Ågerstrand, Carlos Fito, Torben Andersen, Diana Anderson, Enrico Bergamaschi, John W Cherrie, Sue Cowan, Jean-Francois Dalemcourt, Michael Faure, Silke Gabbert, Agnieszka Gajewicz, Teresa F Fernandes, Danail Hristozov, Helinor J Johnston, Terry C Lansdown, Stefan Linder, Hans J P Marvin, Martin Mullins, Kai Purnhagen, Tomasz Puzyn, Araceli Sanchez Jimenez, Janeck J Scott-Fordsmand, George Streftaris, Martie van Tongeren, Nicolas H Voelcker, George Voyiatzis, Spyros N Yannopoulos, P Marijn Poortvliet
Societies worldwide are investing considerable resources into the safe development and use of nanomaterials. Although each of these protective efforts is crucial for governing the risks of nanomaterials, they are insufficient in isolation. What is missing is a more integrative governance approach that goes beyond legislation. Development of this approach must be evidence based and involve key stakeholders to ensure acceptance by end users. The challenge is to develop a framework that coordinates the variety of actors involved in nanotechnology and civil society to facilitate consideration of the complex issues that occur in this rapidly evolving research and development area...
December 14, 2017: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/29235524/multibit-memory-operation-of-metal-oxide-bi-layer-memristors
#14
Spyros Stathopoulos, Ali Khiat, Maria Trapatseli, Simone Cortese, Alexantrou Serb, Ilia Valov, Themis Prodromakis
Emerging nanoionic memristive devices are considered as the memory technology of the future and have been winning a great deal of attention due to their ability to perform fast and at the expense of low-power and -space requirements. Their full potential is envisioned that can be fulfilled through their capacity to store multiple memory states per cell, which however has been constrained so far by issues affecting the long-term stability of independent states. Here, we introduce and evaluate a multitude of metal-oxide bi-layers and demonstrate the benefits from increased memory stability via multibit memory operation...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29209528/cancer-and-the-arts-metastasis-as-perceived-through-the-ages
#15
Spyros Retsas
No abstract text is available yet for this article.
2017: ESMO Open
https://www.readbyqxmd.com/read/29185762/impacts-of-future-european-emission-reductions-on-aerosol-particle-number-concentrations-accounting-for-effects-of-ammonia-amines-and-organic-species
#16
Jan Julin, Benjamin Murphy, David Patoulias, Christos Fountoukis, Tinja Olenius, Spyros Pandis, Ilona Riipinen
Although currently unregulated, atmospheric ultrafine particles (<100 nm) pose risks for health due to e.g. their capability to penetrate deep into the respiratory system. Ultrafine particles, often minor contributors to atmospheric particulate mass, typically dominate aerosol particle number concentrations. We simulated the response of particle number concentrations over Europe to recent estimates of future emission reductions of aerosol particles and their precursors. We used the chemical transport model PMCAMx-UF, with novel updates including state-of-the-art descriptions of ammonia and dimethylamine new particle formation (NPF) pathways and the condensation of organic compounds onto particles...
November 29, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29181143/myeloid-neoplasms-with-isolated-isochromosome-17q-a-yet-to-be-defined-entity
#17
Eleftheria Lamprianidou, Chryssoula Kordella, Menelaos Papoutselis, Zoi Bezyrgiannidou, Evangelia Nakou, Spyros Papamichos, Emmanouil Spanoudakis, Andreas Giannopoulos, Katerina Zoi, Ioannis Kotsianidis
Myeloid neoplasms with isolated isochromosome 17q [MN i(17q)] has been described as a distinct entity with poor prognosis. However, literature reports show a considerable clinical and molecular heterogeneity. We describe a 58-year-old male patient who was diagnosed as refractory anemia with multilineage dysplasia and ringed sideroblasts with isolated i(17q). Though he initially responded well to erythropoietin, he gradually progressed to an aggressive form of MDS/MPN refractory to azacytidine and died 29 months after the first diagnosis...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/29177975/hepatic-safety-analysis-of-trabectedin-results-of-a-pharmacokinetic-study-with-trabectedin-in-patients-with-hepatic-impairment-and-experience-from-a-phase-3-clinical-trial
#18
Emiliano Calvo, Analia Azaro, Jordi Rodon, Luc Dirix, Manon Huizing, Francis Mark Senecal, Patricia LoRusso, Lorrin Yee, Italo Poggesi, Jan de Jong, Spyros Triantos, Youn C Park, Roland E Knoblauch, Trilok V Parekh, George D Demetri, Margaret von Mehren
Purpose Trabectedin is metabolized by the liver and has been associated with transient, noncumulative transaminase elevation. Two recent studies further characterize hepatic tolerability with trabectedin therapy: a phase 1 pharmacokinetic study (Study #1004; NCT01273493) in patients with advanced malignancies and hepatic impairment (HI), and a phase 3 study (Study #3007; NCT01343277) of trabectedin vs. dacarbazine in patients with advanced sarcomas and normal hepatic function. Methods In Study #1004, patients received a single 3-h intravenous (IV) infusion of trabectedin: control group, trabectedin 1...
November 27, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29177612/evaluation-of-colistin-stability-in-agar-and-comparison-of-four-methods-for-mic-testing-of-colistin
#19
Agata Turlej-Rogacka, Basil Britto Xavier, Lore Janssens, Christine Lammens, Olympia Zarkotou, Spyros Pournaras, Herman Goossens, Surbhi Malhotra-Kumar
Susceptibility testing for colistin remains challenging primarily due to its inherent properties. We evaluated colistin stability in agar and reproducibility of colistin MICs obtained by agar dilution, broth macro- and micro-dilution and MIC gradient strips on 3-7 iterations of each method using clinical Klebsiella pneumoniae (susceptible-CS, and resistant-CR, n = 2 each), mcr-harboring Escherichia coli (n = 2), and reference strains E. coli ATCC25922 and Pseudomonas aeruginosa ATCC27853. MICs for reference strains were not in the given range using Etest and broth microdilution (ATCC25922, 0...
November 25, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29174439/vascular-inflammation-and-metabolic-activity-in-hematopoietic-organs-and-liver-in-familial-combined-hyperlipidemia-and-heterozygous-familial-hypercholesterolemia
#20
Konstantinos Toutouzas, John Skoumas, Iosif Koutagiar, Georgios Benetos, Nikoletta Pianou, Alexandros Georgakopoulos, Spyros Galanakos, Alexios Antonopoulos, Maria Drakopoulou, Evangelos K Oikonomou, Pavlos Kafouris, Emmanouil Athanasiadis, Marinos Metaxas, George Spyrou, Zoi Pallantza, Nikolaos Galiatsatos, Constantina Aggeli, Charalampos Antoniades, Georgia Keramida, Adrien M Peters, Constantinos D Anagnostopoulos, Dimitris Tousoulis
BACKGROUND: Familial dyslipidemias of either heterozygous (heFH) or combined (FCH) type lead to accelerated atherogenesis and increased cardiovascular risk. OBJECTIVE: The aim of this study was to investigate in statin-naïve adult patients with familial dyslipidemias whether inflammatory activation and liver, spleen and bone marrow metabolic activity differ compared with normolipidemic subjects and between dyslipidemic groups. METHODS: Fourteen patients with FCH, 14 with heFH, and 14 normolipidemic individuals were enrolled...
November 2, 2017: Journal of Clinical Lipidology
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