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Myocardial perfusion imaging

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https://www.readbyqxmd.com/read/28721647/rubidium-82-pet-imaging-is-feasible-in-a-rat-myocardial-infarction-model
#1
Adam Ali Ghotbi, Andreas Clemmensen, Kasper Kyhl, Bjarke Follin, Philip Hasbak, Thomas Engstrøm, Rasmus Sejersten Ripa, Andreas Kjaer
BACKGROUND: Small-animal myocardial infarct models are frequently used in the assessment of new cardioprotective strategies. A validated quantification of perfusion using a non-cyclotron-dependent PET tracer would be of importance in monitoring response to therapy. We tested whether myocardial PET perfusion imaging is feasible with Rubidium-82 ((82)Rb) in a small-animal scanner using a rat myocardial infarct model. METHODS: 18 Sprague-Dawley rats underwent permanent coronary artery ligation (infarct group), and 11 rats underwent ischemia-reperfusion (reperfusion group) procedure...
July 18, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28718077/early-risk-stratification-using-rubidium-82-positron-emission-tomography-in-stemi-patients
#2
Adam Ali Ghotbi, Philip Hasbak, Lars Nepper-Christensen, Jacob Lønborg, Kiril Atharovski, Thomas Christensen, Lene Holmvang, Thomas Engstrøm, Rasmus Sejersten Ripa, Andreas Kjær
BACKGROUND: Assessment of infarct size after myocardial infarction is predictive of subsequent morphological changes and clinical outcome. This study aimed to assess subacute post-intervention Rubidium-82 ((82)Rb)-PET imaging in predicting left ventricle ejection fraction, regional wall motion, and final infarct size by CMR at 3-months after STEMI. METHODS: STEMI patients undergoing percutaneous coronary intervention were included prospectively. Rest-only (82)Rb-PET perfusion imaging was performed at median 36 hours [IQR: 22 to 50] after the treatment...
July 17, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28712068/qualitative-angiographic-and-quantitative-myocardial-perfusion-assessment-using-fluorescent-cardiac-imaging-during-graded-coronary-artery-bypass-stenosis
#3
Christian Detter, Detlef Russ, Jan Felix Kersten, Hermann Reichenspurner, Sabine Wipper
Intraoperative graft assessment in coronary artery bypass (CAB) grafting is important to avoid early graft failure. This study aimed to evaluate the accuracy of fluorescent cardiac imaging (FCI) for intraoperative qualitative angiographic and quantitative myocardial perfusion assessment during graded CAB stenosis compared to coronary angiography (CA). After CAB grafting to the left anterior descending coronary artery, graded distal bypass stenoses were created in ten pigs by 25, 50, 75, and 100% flow reduction assessed by transit-time flow measurement (TTFM)...
July 15, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28707262/exercise-n-13-cardiac-positron-emission-tomography-myocardial-perfusion-imaging-detecting-ischemia-in-an-adult-patient-with-anomalous-aortic-origin-of-the-left-main-coronary-artery-from-the-right-coronary-sinus
#4
Matthew R Summers, Hani Najm, James L Gentry Iii, Wael A Jaber
Anomalous aortic origin of a coronary artery is a rare congenital condition that has variable presentations from atypical chest pain to syncope and cardiac arrest. Commonly used myocardial perfusion imaging techniques, stress agents, and perfusion agents may have limited ability to detect inducible ischemia in this rare patient group. We herein describe a unique case of anomalous left main coronary artery from a common right coronary sinus ostium with a subpulmonic and intramyocardial course. This patient had multiple atypical chest pain presentations and multiple-negative pharmacologic single-photon emission-computed tomography stress tests performed...
July 13, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28699019/the-diagnostic-performance-of-spect-mpi-to-predict-functional-significant-coronary-artery-disease-by-fractional-flow-reserve-derived-from-ccta-ffrct-sub-analysis-from-accuracy-and-vct001-studies
#5
Rine Nakanishi, Kazuhiro Osawa, Indre Ceponiene, Glenn Huth, Jason Cole, Michael Kim, Negin Nezarat, Sina Rahmani, Dong Li, Souma Gupta, Campbell Rogers, Christopher Dailing, Matthew J Budoff
Although single photon emission computed tomography-myocardial perfusion image (SPECT-MPI) and fractional flow reserve (FFR) derived from coronary computed tomographic angiography (CCTA) (FFRCT) have permitted functional assessment of coronary artery disease (CAD), the concordance between these modalities has not been well described. The aim of this study is to compare SPECT-MPI and anatomical stenosis by CCTA and invasive coronary angiography to FFRCT for assessing functional significance of CAD. We identified 62 patients with suspected CAD who underwent ≥64 slice coronary CTA and SPECT-MPI within 3 months...
July 11, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28695497/comparison-of-ctac-and-prone-imaging-for-the-detection-of-coronary-artery-disease-using-czt-spect
#6
Shimpei Ito, Akihiro Endo, Taiji Okada, Taku Nakamura, Takashi Sugamori, Nobuyuki Takahashi, Hiroyuki Yoshitomi, Kazuaki Tanabe
BACKGROUND: Cadmium-zinc-telluride (CZT) cameras have improved the evaluation of patients with chest pain. However, inferior/inferolateral attenuation artifacts similar to those seen with conventional Anger cameras persist. We added prone acquisitions and CT attenuation correction (CTAC) to the standard supine image acquisition and analyzed the resulting examinations. METHODS AND RESULTS: Seventy-two patients referred for invasive coronary angiography (CAG), and who also underwent rest/stress myocardial perfusion imaging (MPI) on a CZT camera in the supine and prone positions plus CTAC imaging, to examine known or suspected CAD between April 2013 and March 2014 were included...
July 10, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28695407/nuclear-cardiology-in-china-2017
#7
Gongshun Tang
This paper provides the current state of nuclear cardiology in China and contrasts it with the state of nuclear cardiology in the United States (US). The West China Hospital and New York-Presbyterian Hospital (NYPH) were used as representative hospitals to contrast nuclear cardiology in China and the US, respectively. In 2015, there were 101 medical cyclotrons, 774 SPECT or SPECT/CT, 240 PET/CT, and 6 PET/MR cameras in China. Most (~90%) of the nuclear cardiology studies are gated SPECT myocardial perfusion imaging (MPI), and ~10% are other types of studies including MUGA, PET/CT MPI, and viability studies...
July 10, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28693906/reproducible-computer-assisted-quantification-of-myocardial-perfusion-with-contrast-enhanced-ultrasound
#8
Yuanwei Li, Navtej Chahal, Roxy Senior, Meng-Xing Tang
Myocardial perfusion can be quantified by myocardial contrast echocardiography (MCE) and is used for the diagnosis of coronary artery disease (CAD). However, existing MCE quantification software is highly operator dependent and has poor reproducibility and ease of usage. The aim of this study was to develop robust and easy-to-use software that can perform MCE quantification accurately, reproducibly and rapidly. The developed software has the following features: (i) semi-automatic segmentation of the myocardium; (ii) automatic rejection of MCE data with poor image quality; (iii) automatic computation of perfusion parameters such as myocardial blood flow (MBF)...
July 7, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28692492/criteria-for-the-addition-of-prone-imaging-to-myocardial-perfusion-single-photon-emission-computed-tomography-for-inferior-wall
#9
Koji Nakaya, Masahisa Onoguchi, Yoshihiro Nishimura, Keisuke Kiso, Hideki Otsuka, Yoshifumi Nouno, Takayuki Shibutani, Eisuke Yasuda
OBJECTIVE: Myocardial perfusion single-photon emission computed tomography (SPECT) is occasionally suspected to generate images that represent either ischemia or infarction for the inferior wall [right coronary artery (RCA) disease] or attenuation artifacts because of the diaphragm. We often encounter this. The application of prone imaging is advantageous in the differentiation of RCA disease because of attenuation artifacts. If decreased accumulation of radioisotopes is observed at the site with either RCA disease or attenuation artifacts, then a criterion that enables the addition of prone imaging should be implemented...
July 7, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28687967/relationship-of-non-invasive-quantification-of-myocardial-blood-flow-to-arrhythmic-events-in-patients-with-implantable-cardiac-defibrillators
#10
Michael Ghannam, Krasimira Mikhova, Hong Jun Yun, John J Lazarus, Matthew Konerman, Ashraf Saleh, Richard L Weinberg, Ryan Cunnane, Ravi V Shah, Keri M Hiller, Edward P Ficaro, James R Corbett, Venkatesh L Murthy
BACKGROUND: Ischemia contributes to arrhythmogenesis though its role is incompletely understood. Abnormal myocardial perfusion measured by PET imaging may predict ventricular arrhythmias (VAs) in a high-risk population. METHODS: Patients with implantable cardiac defibrillators who had undergone rubidium-82 cardiac PET imaging were identified. Patients were stratified by median MBF and MFR values for analysis. The Cox proportional hazards model was used to assess the impact of myocardial perfusion on survival free of VT independent of critical covariates...
July 7, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28687538/temporal-trends-of-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-in-patients-with-coronary-artery-disease-a-22-year-experience-from-a-tertiary-academic-medical-center
#11
Hayan Jouni, J Wells Askew, Daniel J Crusan, Todd D Miller, Raymond J Gibbons
BACKGROUND: There has been a gradual decline in the prevalence of abnormal stress single-photon emission computed tomography (SPECT) myocardial perfusion imaging studies among patients without history of coronary artery disease (CAD). The trends of SPECT studies among patients with known CAD have not been evaluated previously. METHODS AND RESULTS: We assessed the Mayo Clinic nuclear cardiology database for all stress SPECT tests performed between January 1991 and December 2012 in patients with history of CAD defined as having previous myocardial infarction, percutaneous coronary intervention, and coronary artery bypass grafting...
July 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28685253/detection-and-quantitation-of-right-ventricular-reversible-perfusion-defects-by-stress-spect-myocardial-perfusion-imaging-a-proof-of-principle-study
#12
Ayman A Farag, Jack Heo, Lindsey Tauxe, Pradeep Bhambhvani, Guido Germano, Paul Kavanagh, Ami E Iskandrian, Fadi G Hage
BACKGROUND: In patients with right dominant coronary circulation, the right ventricular (RV) myocardium and the inferior region of the left ventricular (LV) myocardium share a common source of blood flow. We hypothesized that stress/rest SPECT myocardial perfusion imaging (MPI) could detect reversible perfusion defects in the RV in some patients with LV inferior wall perfusion abnormalities. MATERIAL AND METHODS: We identified 2 groups of patients with LV inferior wall perfusion defects (with or without defects in other regions of LV myocardium) from our database...
July 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28685251/corrected-coronary-opacification-decrease-from-coronary-computed-tomography-angiography-validation-with-quantitative-13n-ammonia-positron-emission-tomography
#13
Dominik C Benz, Christoph Gräni, Paola Ferro, Luis Neumeier, Michael Messerli, Mathias Possner, Olivier F Clerc, Catherine Gebhard, Oliver Gaemperli, Aju P Pazhenkottil, Philipp A Kaufmann, Ronny R Buechel
BACKGROUND: To assess the functional relevance of a coronary artery stenosis, corrected coronary opacification (CCO) decrease derived from coronary computed tomography angiography (CCTA) has been proposed. The present study aims at validating CCO decrease with quantitative 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI). METHODS AND RESULTS: This retrospective study consists of 39 patients who underwent hybrid CCTA/PET-MPI. From CCTA, attenuation in the coronary lumen was measured before and after a stenosis and corrected to the aorta to calculate CCO and its decrease...
July 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28685228/relationship-between-coronary-contrast-flow-quantitative-flow-ratio-and-myocardial-ischemia-assessed-by-spect-mpi
#14
Jeff M Smit, Gerhard Koning, Alexander R van Rosendael, Petra Dibbets-Schneider, Bart J Mertens, J Wouter Jukema, Victoria Delgado, Johan H C Reiber, Jeroen J Bax, Arthur J Scholte
PURPOSE: A new method has been developed to calculate fractional flow reserve (FFR) from invasive coronary angiography, the so-called "contrast-flow quantitative flow ratio (cQFR)". Recently, cQFR was compared to invasive FFR in intermediate coronary lesions showing an overall diagnostic accuracy of 85%. The purpose of this study was to investigate the relationship between cQFR and myocardial ischemia assessed by single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI)...
July 6, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28685008/stress-spect-myocardial-perfusion-imaging-in-end-stage-renal-disease
#15
Yasmeen Golzar, Rami Doukky
PURPOSE OF REVIEW: Patients with end-stage renal disease (ESRD) have an increased risk of cardiovascular morbidity and mortality. Cardiac risk assessment, though challenging, is critical in these high-risk patients, particularly in the pre-transplant population. In this review, we discuss the burden of coronary artery disease in the ESRD population and review the literature on the diagnostic and prognostic performance, clinical value, and future directions of single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) in ESRD patients...
May 2017: Current Cardiovascular Imaging Reports
https://www.readbyqxmd.com/read/28683710/-asystole-after-regadenoson-administration-to-perform-a-myocardial-perfusion-imaging-test
#16
Daniel Briegas Morera, Susana Martín Clavo, María José Estepa Alonso, Juan Francisco Rangel Mayoral
No abstract text is available yet for this article.
July 1, 2017: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/28680214/ectopic-parathyroid-incidentaloma-on-tc99m-sestamibi-myocardial-perfusion-imaging
#17
Rola Aatif Hasan Hussain, Ammar Mohammed Saeed Ali, K Manivannan, S K Chirala
Parathyroid incidentalomas are generally discovered during thyroid surgery.([1]) In the present case, the ectopic parathyroid adenoma was discovered as an incidentaloma in a clinical setting, during the course of clinical evaluation of atypical chest pain by gastroenterology and cardiology.
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28680199/diagnostic-accuracy-of-stress-myocardial-perfusion-imaging-in-indian-diabetic-patients-a-single-centre-experience
#18
Deepa Kumar, Ravinder Singh Sethi, Sandeep Bansal, Padma A Namgyal, Aditi Khurana Sehgal, Tajamul Syed Malik
Diabetics have around 2-4 times increased risk of coronary artery disease(CAD) and it is the most important cause of mortality in these patients. This study was carried out to compare the sensitivity, specificity and accuracy of MPI-SPECT among diabetics and non-diabetics in the Indian population. MATERIAL AND METHODS: This retrospective study included 261 patients; 213 males and 48 females, with 75 diabetic and 186 non-diabetic patients. Only type II diabetics and non-diabetic patients were included in the study...
July 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28674630/a-specialty-specific-multimodality-educational-quality-improvement-initiative-to-deimplement-rarely-appropriate-myocardial-perfusion-imaging
#19
David E Winchester, Carsten Schmalfuss, Christian D Helfrich, Rebecca J Beyth
OBJECTIVE: Investigations of Appropriate Use Criteria (AUC) education have shown a mixed effect on changing provider behaviour. At our facility, rarely appropriate myocardial perfusion imaging (MPI) differs by specialty; awareness of AUC is low. Our objective is to investigate if specialty-specific, multimodality education could reduce rarely appropriate MPI. METHODS: We designed education focused on the rarely appropriate MPI ordered most often by each specialty...
2017: Open Heart
https://www.readbyqxmd.com/read/28673042/independent-prognostic-value-of-left-ventricular-contractile-reserve-and-chronotropic-response-in-patients-with-reduced-left-ventricular-ejection-fraction-undergoing-vasodilator-stress-myocardial-perfusion-imaging-with-rb-82-positron-emission-tomography
#20
Balaji K Tamarappoo, Lee Fong Ling, Manuel Cerqueira, Rory Hachamovitch
Objectives: We evaluated the prognostic value of heart rate reserve (ΔHR) and left ventricular ejection fraction reserve (ΔLVEF) among patients with systolic dysfunction. Background: Inadequate ΔHR (maximal stress HR - resting HR) and ΔLVEF (LVEF at stress - LVEF at rest) in response to stress are associated with adverse cardiac events. However, the significance of an abnormal ΔHR and ΔLVEF in patients with systolic dysfunction has not been described. Methods and results: We performed a retrospective analysis of patients with rest LVEF < 45% who underwent dipyridamole stress-rest gated Rb-82 PET myocardial perfusion imaging (PET-MPI) at the Cleveland Clinic between 2006 and 2009...
June 29, 2017: European Heart Journal Cardiovascular Imaging
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