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Hashimoto's Thyroiditis

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https://www.readbyqxmd.com/read/28327620/correlation-between-ultrasound-elastography-and-histologic-characteristics-of-papillary-thyroid-carcinoma
#1
Li Yi, Wu Qiong, Wang Yan, Fan Youben, Hu Bing
The aim of this study was to investigate the correlation between elastography and histologic characteristics including fibrosis and calcification. We also wanted to investigate whether other clinicopathologic indexes influence the strain ratio (SR) of papillary thyroid carcinomas (PTCs). We retrospectively reviewed 126 papillary thyroid carcinomas (PTCs) from 103 patients who underwent ultrasonography and elastography before surgery. The histologic characteristics and clinicopathologic indexes were compared with the SR of ultrasound elastography (UE)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28323998/genes-outside-the-major-histocompatibility-complex-mhc-locus-are-linked-to-the-development-of-thyroid-autoantibodies-and-thyroiditis-in-nod-h2h4-mice
#2
Sandra M McLachlan, Sylvie Lesage, Roxanne Collin, Bianca Banuelos, Holly A Aliesky, Basil Rapoport
Thyroiditis and autoantibodies to thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) develop spontaneously in NOD.H2h4 mice, a phenotype enhanced by dietary iodine. NOD.H2h4 mice were derived by introducing the Major Histocompatibility Class (MHC) molecule I-Ak from B10.A(4R) mice to non-obese diabetic (NOD) mice. Apart from I-Ak, the genes responsible for the NOD.H2h4 phenotype are unknown. Extending serendipitous observations from crossing BALB/c to NOD.H2h4 mice, thyroid autoimmunity was investigated in both genders of the F1, F2 and the second generation backcross of F1 to NOD...
January 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323932/active-surveillance-for-patients-with-papillary-thyroid-microcarcinoma-a-single-center-s-experience-in-korea
#3
Hyemi Kwon, Hye-Seon Oh, Mijin Kim, Suyeon Park, Min Ji Jeon, Won Gu Kim, Won Bae Kim, Young Kee Shong, Dong Eun Song, Jung Hwan Baek, Ki-Wook Chung, Tae Yong Kim
Context: Papillary thyroid microcarcinoma (PTMC) usually has an excellent prognosis. Objective: To evaluate the 3-dimensional structures of PTMCs using serial neck ultrasonography (US) in patients under active surveillance. Design and Setting: A retrospective cohort study. Participants: In total, 192 patients diagnosed with PTMC under active surveillance for more than 1 year were included in a median 30-month follow-up...
March 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323630/low-thyroid-hashimoto-s-disease-and-pregnancy
#4
Jeffrey Dach
No Abstract Available.
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28323379/effects-of-short-term-levothyroxine-therapy-on-myocardial-injuries-in-patients-with-severe-overt-hypothyroidism-evidence-from-a-cardiac-mri-study
#5
Xia Gao, Zhe Chen, Min Liu, Yu-Mei Jia, Ning Yang, Zhi Yao, Xiao-Meng Feng, Yuan Xu, Guang Wang
PURPOSE: To investigate using magnetic resonance imaging (MRI) myocardial injuries and cardiac function in patients with newly diagnosed severe primary overt hypothyroidism (HT) before and after achieving euthyroidism by short-term levothyroxine treatment. Levothyroxine treatment improves cardiovascular performance and ventricular remodeling in patients with HT, but diffuse myocardial injuries induced by HT are difficult to detect clinically. MATERIALS AND METHODS: Myocardial longitudinal relaxation time (T1 ) mapping using the modified Look-Locker inversion-recovery (MOLLI) sequences at 3...
March 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28315909/a-concise-review-of-hashimoto-thyroiditis-ht-and-the-importance-of-iodine-selenium-vitamin-d-and-gluten-on-the-autoimmunity-and-dietary-management-of-ht-patients-points-that-need-more-investigation
#6
REVIEW
Michael I Liontiris, Elias E Mazokopakis
Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroid disease caused by an interaction between genetic factors and environmental conditions, both of which are yet to be fully understood. The management of HT depends on its clinical manifestations, commonly including diffuse or nodular goiter with euthyroidism, subclinical hypothyroidism and permanent hypothyroidism. However, in most cases of patients with HT, lifelong levothyroxine substitution is required. The additional role of diet for the management of HT is usually overlooked...
March 20, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28293260/treatment-with-myo-inositol-and-selenium-ensures-euthyroidism-in-patients-with-autoimmune-thyroiditis
#7
Maurizio Nordio, Sabrina Basciani
Clinical evidences have highlighted the efficacy of myo-inositol and selenium in the treatment of autoimmune thyroiditis. Aim of this study was to further analyze the role of myo-inositol plus selenium (Myo-Ins-Se) in restoring a normal thyroid function of Hashimoto's patients with subclinical hypothyroidism. Eighty-six patients with Hashimoto's thyroiditis having thyroid-stimulating hormone (TSH) levels between 3 and 6 mIU/L, elevated serum antithyroid peroxidase (TPOAb) and/or antithyroglobulin (TgAb), and normal free thyroxine (fT4) and free triiodothyronine (fT3) levels were enrolled in the study: one hyperthyroid subject with TSH about 0...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28290237/multiple-nutritional-factors-and-the-risk-of-hashimoto-s-thyroiditis
#8
Shiqian Hu, Margaret P Rayman
Background Hashimoto's Thyroiditis (HT) is considered to be the most common autoimmune disease. It is currently accepted that genetic susceptibility, environmental factors and immune disorders contribute to its development. Regarding nutritional factors, evidence implicates high iodine intake, deficiencies of selenium and iron with a potential relevance of vitamin D status. To elucidate the role of nutritional factors in the risk, pathogenesis and treatment of Hashimoto's Thyroiditis (HT), PubMed and the Cochrane Library were searched for publications on iodine, iron, selenium and vitamin D and risk/treatment of HT...
March 14, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28288723/clinical-features-and-management-of-non-gastrointestinal-non-ocular-extranodal-mucosa-associated-lymphoid-tissue-enmalt-marginal-zone-lymphomas
#9
REVIEW
Estella Matutes, Carlos Montalban
Extranodal mucosa associated lymphoid tissue (ENMALT) marginal zone lymphomas may arise at any site of the body. The most frequent localizations other than gastrointestinal and eye are salivary gland, skin, lung and thyroid. These lymphomas usually arise in a setting of inflammation due to a persistent infection or autoimmune diseases such as Sjogren syndrome in salivary MALT lymphomas and Hashimoto's thryroiditis in thyroid lymphomas. They affect middle-aged patients with a female predominance when lymphoma arises in certain locations...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28288719/marginal-zone-lymphoma-associated-autoimmunity-and-auto-immune-disorders
#10
REVIEW
Larissa Sena Teixeira Mendes, Andrew Wotherspoon
Large epidemiological studies have shown a consistent increased risk for developing lymphoma in the setting of autoimmune disorders (AID). It is known that this link appears to be stronger for some AID and certain non-Hodgkin lymphoma subtypes e.g. Sjögren's syndrome and extra-nodal marginal zone lymphoma of the salivary gland, and thyroid MALT lymphoma in a background of Hashimoto's thyroiditis. B and T-cell hyperactivity due to chronic antigenic stimulation and the consequent presence of acquired lymphoid tissue seems to play a key role in the pathogenesis of AI-related lymphomas...
March 2017: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/28287071/auditory-seizures-in-autoimmune-epilepsy-a-case-with-anti-thyroid-antibodies
#11
Claudia Varrasi, Domizia Vecchio, Luca Magistrelli, Gionata Strigaro, Laura Tassi, Roberto Cantello
In its classic presentation, Hashimoto's encephalopathy is an acute-subacute complex neuropsychiatric syndrome with cognitive impairment, hallucinations, myoclonus, tremor or ataxia, associated with elevated anti-thyroid antibodies. Corticoids and immunotherapy are dramatically effective. However, in some cases, not all the associated features are presented and this delays diagnosis and appropriate treatment. We describe a man with abrupt onset of recurrent auditory seizures resulting in refractory non-convulsive status epilepticus...
March 8, 2017: Epileptic Disorders: International Epilepsy Journal with Videotape
https://www.readbyqxmd.com/read/28276714/diagnostic-significance-of-serum-concentrations-of-soluble-fas-ligand-sfasl-in-children-with-autoimmune-thyroid-disease
#12
Hanna Mikos, Marcin Mikos, Marek Niedziela
INTRODUCTION: The aim of the study was to assess serum levels of sFasL as a marker of thyroid dysfunction in children with autoimmune thyroid disease (AITD). DESIGN: The group comprised 45 newly diagnosed children with Hashimoto's thyroiditis and Graves' disease versus euthyroid control group: 11 with hypothyroidism (10 girls and 1 boy, aged 12.2 ± 1.9 years), 19 children with hyperthyroidism (15 girls and 4 boys, aged 12.4 ± 4.9 years) and 15 healthy subjects (7 girls and 8 boys, aged 10...
February 21, 2017: Autoimmunity
https://www.readbyqxmd.com/read/28273382/hashimoto-s-thyroiditis-relative-recurrence-risk-ratio-and-implications-for-screening-of-first-degree-relatives
#13
Nikita Bothra, Nalini Shah, Manjunath Goroshi, Swati Jadhav, Sheetal Padalkar, Hemangini Thakkar, Gurudayal Singh Toteja, Vyankatesh Shivane, Anurag Lila, Tushar Bandgar
CONTEXT: The relative recurrence risk ratio (λR ) for Hashimoto's thyroiditis (HT) has not been widely studied. The age at which thyroid function evaluation should be initiated for relatives of HT patients remains unclear. OBJECTIVE: To study λR and age-related prevalence of HT in first degree relatives of HT patients. METHODS: First degree relatives (n=861) of 264 HT patients were evaluated for goitre, thyroid function tests, thyroid antibodies (TAb) and urinary iodide concentration (UIC)...
March 8, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28272206/limbic-encephalitis-associated-with-anti-nh2-terminal-of-%C3%AE-enolase-antibodies-a-clinical-subtype-of-hashimoto-encephalopathy
#14
Toru Kishitani, Akiko Matsunaga, Masamichi Ikawa, Kouji Hayashi, Osamu Yamamura, Tadanori Hamano, Osamu Watanabe, Keiko Tanaka, Yasunari Nakamoto, Makoto Yoneda
Several types of autoantibodies have been reported in autoimmune limbic encephalitis (LE), such as antibodies against the voltage-gated potassium channel (VGKC) complex including leucine-rich glioma inactivated 1 (LGI1). We recently reported a patient with autoimmune LE and serum anti-NH2-terminal of α-enolase (NAE) antibodies, a specific diagnostic marker for Hashimoto encephalopathy (HE), who was diagnosed with HE based on the presence of antithyroid antibodies and responsiveness to immunotherapy. This case suggests that LE patients with antibodies to both the thyroid and NAE could be diagnosed with HE and respond to immunotherapy...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28262212/type-b-insulin-resistance-in-peru
#15
Henry Zelada, Dante Gamarra, Hugo Arbañil, Helard Manrique
Type B insulin resistance (IR) is a rare autoimmune disease characterized by the presence of insulin receptor autoantibodies, resulting in a marked IR inducing hyperglycemia. Our first case is a 42-year-old female with a history of RA, SLE and Hashimoto-thyroiditis that presented with cachexia, acanthosis-nigricans, hirsutism, negative anti-insulin-ab and glucose level between 400 to 700 mg/dl, despite a total insulin dose of 1000 IU/day. She received pulses of cyclophosphamide along with prednisone. One year later the patient was off insulin and with HbA1c of 5...
March 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28260699/is-thyroid-autoimmunity-itself-associated-with-psychological-well-being-in-euthyroid-hashimoto-s-thyroiditis
#16
Mehmet Muhittin Yalcin, Alev Eroglu Altinova, Burcak Cavnar, Basak Bolayir, Mujde Akturk, Emre Arslan, Cigdem Ozkan, Nuri Cakir, Fusun Balos Toruner
Recent studies imply that euthyroid Hashimoto's thyroiditis (HT) might be related with impaired HRQoL, depression and anxiety. Ninety three patients with euthyroid HT and 31 age- and gender-matched euthyroid control subjects were enrolled into this study. SF-36 questionnaire, Beck Depression Inventory and Beck Anxiety Inventory tests were used for evaluating HRQoL, depression and anxiety. Beck Depression Inventory scores were higher in patients with HT compared to control subjects (7.5 (4.0-14.75) vs. 5.0 (2...
March 4, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28249644/lymph-node-characteristics-for-predicting-locoregional-recurrence-of-papillary-thyroid-cancer-in-adolescents-and-young-adults
#17
Yungang Sun, Xiang Liu, Wei Ouyang, Huijuan Feng, Juqing Wu, Pan Chen, Jing Wang
PURPOSE: To determine lymph node (LN) characteristics predictive of locoregional recurrence (LRR) in adolescent and young adult (AYA) ages 15-39years presenting with papillary thyroid cancer (PTC) and cervical pathologically proven LN metastases (pN1). METHODS AND MATERIALS: Retrospective chart review was performed for all patients with PTC and nodal metastases who had undergone total thyroidectomy, LN dissection, and postoperative radioactive iodine therapy in a university hospital between 2006 and 2014...
March 2017: Oral Oncology
https://www.readbyqxmd.com/read/28245458/endocrine-autoimmunity-in-down-s-syndrome
#18
Federica Guaraldi, Ruth Rossetto Giaccherino, Fabio Lanfranco, Giovanna Motta, Davide Gori, Emanuela Arvat, Enzio Ghigo, Roberta Giordano
Since the mid 1900s, a significant increase of infectious, hematological, and autoimmune diseases has been reported in patients with Down's syndrome (DS), independent of sex, age, family history, and exposure to other risk factors, suggesting an intrinsic alteration of the immune system. Several in vitro and in vivo studies have demonstrated alterations of both cellular and humoral immunological response mainly, although not exclusively, secondary to alterations of the expression of autoimmune regulator gene (located on chromosome 21), leading to thymic structural and functional impairments...
2017: Frontiers of Hormone Research
https://www.readbyqxmd.com/read/28238453/vitiligo-and-overt-thyroid-diseases-a-nationwide-population-based-study-in-korea
#19
Jung Min Bae, June Hyunkyung Lee, Jae Seung Yun, Byeol Han, Tae Young Han
BACKGROUND: Associations between vitiligo and thyroid diseases have been reported repeatedly. OBJECTIVE: We investigated the associations between vitiligo and overt autoimmune thyroid diseases and thyroid cancer using the Korean National Health Insurance claims database. METHODS: We defined patients with vitiligo as those whose records showed ≥4 physician contacts between 2009 and 2013 in which vitiligo was the principal diagnosis. We also established an age- and sex-matched control group without vitiligo (2 per 1 vitiligo patient)...
February 23, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28229097/pediatric-hypovitaminosis-d-molecular-perspectives-and-clinical-implications
#20
Rafiu Ariganjoye
Vitamin D, a secosteroid, is essential for the development and maintenance of healthy bone in both the adult and pediatric populations. Low level of 25-hydroxy vitamin D (25-(OH)-D) is highly prevalent in children worldwide and has been linked to various adverse health outcomes including rickets, osteomalacia, osteomalacic myopathy, sarcopenia, and weakness, growth retardation, hypocalcemia, seizure and tetany, autism, cardiovascular diseases, diabetes mellitus, cancers (prostate, colon, breast), infectious diseases (viral, tuberculosis), and autoimmune diseases, such as multiple sclerosis and Hashimoto's thyroiditis...
2017: Global Pediatric Health
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