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Hashimoto's Thyroiditis

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https://www.readbyqxmd.com/read/28428677/hypothyroidism-in-pediatric-population-bosnian-and-herzegovinian-situation
#1
Edo Hasanbegovic, Snijezana Hasanbegovic, Edin Begic
INTRODUCTION: Thyroid gland diseases in children are in second place by frequency among all endocrine disorders. When interpreting the results of the thyroid function assessment it should be taken into account the significant differences in the concentrations of TSH, thyroid hormones, thyroid binding proteins and calcitonin among children of different ages. GOAL: To present the age and sex structure of the patients diagnosed with hypothyroidism, evaluate diagnostic methods for making diagnosis, evaluation of etiology of hypothyroidism, with special review of the therapeutic modality...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28419663/total-thyroidectomy-for-pressure-symptoms-in-patients-with-hashimoto-s-thyroiditis
#2
Katrina Heggie, Meei Yeung, Simon Grodski, James Lee, Jonathan Serpell
BACKGROUND: Hashimoto's thyroiditis (HT) is rarely on its own the indication for thyroidectomy. However, surgery in patients with HT will be undertaken when there is malignancy and may be required for pressure symptoms. Therefore, this study aimed to investigate the indications for surgery in HT patients. METHODS: The Monash University Endocrine Surgery Database was analysed from 1994 to 2013 for patients with HT. Patients with HT were compared to a similar group of patients with no HT on histopathology...
April 16, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28413173/25-hydroxyvitamin-d-serum-level-in-hashimoto-s-thyroiditis-but-not-graves-disease-is-relatively-deficient
#3
Wencai Ke, Tiange Sun, Yanan Zhang, Leqi He, Qiang Wu, Jun Liu, Bingbing Zha
Vitamin D is a modulator of both the innate and adaptive immune system. As vitamin D deficiency was a risk factor for some autoimmune diseases, we aimed to evaluate the serum vitamin D levels in autoimmune thyroid diseases (AITD) including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT) and investigated the association between serum vitamin D levels and AITD. 175 AITD patients including 51 GD, 61 euthyroid HT (mild HT), 63 euthyroid HT patients with hypothyroidism receiving hormone therapy (treated HT) were recruited from the outpatient department...
April 11, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28407273/comorbidity-of-chronic-spontaneous-urticaria-and-autoimmune-thyroid-diseases-a-systematic-review
#4
REVIEW
Pavel Kolkhir, Martin Metz, Sabine Altrichter, Marcus Maurer
Chronic spontaneous urticaria (CSU) patients are widely held to often have other autoimmune disorders, including autoimmune thyroid disease. Here, we systematically evaluated the literature on the prevalence of thyroid autoimmunity in CSU and vice versa. There is a strong link between CSU and elevated levels of IgG anti-thyroid autoantibodies (AAbs), with most of a large number of studies reporting rates of ≥10%. Levels of IgG against thyroid peroxidase (TPO) are more often elevated in CSU than those of other IgG anti-thyroid AAbs (strong evidence)...
April 13, 2017: Allergy
https://www.readbyqxmd.com/read/28403750/improvement-of-the-classification-quality-in-detection-of-hashimoto-s-disease-with-a-combined-classifier-approach
#5
Zbigniew Omiotek
The purpose of the study was to construct an efficient classifier that, along with a given reduced set of discriminant features, could be used as a part of the computer system in automatic identification and classification of ultrasound images of the thyroid gland, which is aimed to detect cases affected by Hashimoto's thyroiditis. A total of 10 supervised learning techniques and a majority vote for the combined classifier were used. Two models were proposed as a result of the classifier's construction. The first one is based on the K-nearest neighbours method (for K = 7)...
April 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28400827/effects-of-vitamin-d-deficiency-treatment-on-metabolic-markers-in-hashimoto-thyroiditis-patients
#6
Parichehr Vahabi Anaraki, Ashraf Aminorroaya, Massoud Amini, Awat Feizi, Bijan Iraj, Azamosadat Tabatabaei
BACKGROUND: The aim of the current trial was to investigate the effect of Vitamin D treatment on metabolic markers in people with Vitamin D deficiency and thyroid autoimmunity. MATERIALS AND METHODS: In this double-blind, randomized, placebo-controlled clinical trial, 65 Vitamin D deficient euthyroid or hypothyroid patients with positive TPO-Ab were enrolled. They randomly allocated into two groups to receive oral Vitamin D3 (50000 IU weekly) and placebo for 12 weeks...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28394968/-autoimmune-encephalitis-induced-by-antibodies-against-gaba-a-receptor
#7
Pablo González R, Lorena Hudson A, Esteban Basáez M, Marcelo Miranda C
Among autoimmune encephalitides, a prevalent group are those associated with antibodies against the N-Methyl-D-aspartate receptor, which present with behavior abnormalities, psychosis, seizures and abnormal movements. A new variant, mediated by antibodies against the GABA-A receptor, was recen-tly described. We report a 66-years-old female with this form of encephalitis whose main manifestation was the presence of severe seizures leading to status epilepticus. The patient had a good response to immunomodulatory therapy with intravenous methylprednisolone, azathioprine and anticonvulsants...
November 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28392654/concurrent-linear-immunoglobulin-a-dermatosis-hashimoto-thyroiditis-and-immunoglobulin-a-nephropathy-in-an-adult
#8
Ji Young Yang, Inwhee Park, Sue Kyung Kim
No abstract text is available yet for this article.
April 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28387647/management-of-childhood-thyroid-nodules-surgical-and-endocrinological-experience-in-more-than-one-hundred-cases
#9
Emre Divarcı, Ülgen Celtik, Zafer Dökümcü, Orkan Ergün, Geylani Özok, Samim Özen, Damla Gökşen Şimşek, Şükran Darcan, Nazan Çetingül, Aylin Oral, Yeşim Ertan, Bengü Demirağ, Ahmet Çelik
OBJECTIVE: The management of childhood thyroid nodules is still a big challenge for clinicians. In this study, we aimed to present our surgical and endocrinological experience in more than one hundred cases as a large experience in children. METHODS: Retrospective analysis of patients admitted with a thyroid nodule between 2006-2014 was performed. Detailed ultrasonography and fine needle aspiration biopsy(FNAB) were the corner stones of the diagnostic approach. RESULTS: One hundred-three children(72F,31M) with a mean age of 13...
April 7, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28382784/the-impact-of-presence-of-hashimoto-s-thyroiditis-on-diagnostic-accuracy-of-ultrasound-guided-fine-needle-aspiration-biopsy-in-subcentimeter-thyroid-nodules-a-retrospective-study-from-fuscc
#10
Lili Gao, Ben Ma, Li Zhou, Yu Wang, Shuwen Yang, Ning Qu, Yi Gao, Qinghai Ji
The incidence of PTMC has been increasing in the recent years. This study aimed to investigate the diagnostic value of US-FNA in thyroid nodules ≤1 cm and whether the presence of Hashimoto's thyroiditis (HT) in thyroid could influence the accuracy. The patients who accepted US-FNA at FUSCC from December 2012 to November 2015 and followed our criteria were enrolled in this study. We extracted the cytological, pathological, and follow-up US/US-FNA data of patients with subcentimeter nodules. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), false-negative rate (FNR), false-positive rate (FPR), and AUC were calculated to define FNA diagnostic performance in patients...
April 5, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28382505/association-of-established-hypothyroidism-associated-genetic-variants-with-hashimoto-s-thyroiditis
#11
A Barić, L Brčić, S Gračan, V Torlak Lovrić, I Gunjača, M Šimunac, M Brekalo, M Boban, O Polašek, M Barbalić, T Zemunik, A Punda, V Boraska Perica
PURPOSE: Hashimoto's thyroiditis (HT) as a chronic autoimmune disease of the thyroid gland is the most common cause of hypothyroidism. Since HT and hypothyroidism are closely related, the main aim of this study was to explore the association of established hypothyroidism single-nucleotide polymorphisms (SNPs) with HT. METHODS: The case-control dataset included 200 HT cases and 304 controls. Diagnosis of HT cases was based on clinical examination, measurement of thyroid antibodies (TgAb, TPOAb), hormones (TSH and FT4) and ultrasound examination...
April 5, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28382288/routine-calcitonin-measurement-in-nodular-thyroid-disease-management-is-it-worthwhile
#12
Yigit Turk, Ozer Makay, Murat Ozdemir, Gozde Ertunc, Batuhan Demir, Gokhan Icoz, Mahir Akyildiz, Mustafa Yilmaz
PURPOSE: To evaluate the diagnostic accuracy of routine calcitonin measurement in patients with nodular thyroid disease. METHODS: Consecutive patients with nodular thyroid disease (n = 640) were studied. Serum calcitonin levels were measured under basal conditions, and when basal values were between 10-100 pg/mL, testing was repeated after pentagastrin (PG) stimulation. Patients with previously diagnosed or familial medullary thyroid cancer (MTC) were excluded. Patients were operated on when basal or stimulated calcitonin >100 pg/mL or when other surgical indications were present...
April 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28348002/thyroid-function-in-children-and-adolescents-with-hashimoto-s-thyroiditis-after-l-thyroxine-discontinuation
#13
Giorgio Radetti, Mariacarolina Salerno, Chiara Guzzetti, Marco Cappa, Andrea Corrias, Alessandra Cassio, Graziano Cesaretti, Roberto Gastaldi, Mario Rotondi, Fiorenzo Lupi, Antonio Fanolla, Giovanna Weber, Sandro Loche
OBJECTIVE: Thyroid function may recover in patients with Hashimoto's thyroiditis (HT). DESIGN: To investigate thyroid function and the need to resume l-thyroxine treatment after discontinuation. SETTING: Nine Italian Pediatric Endocrinology centers. PATIENTS: 148 children and adolescents (25 m and 123 f) with HT on treatment with l-thyroxine for at least one year. Intervention and Main Outcome measure: Treatment was discontinued in all patients, and serum TSH and fT4 concentrations were measured at the time of treatment discontinuation and then after 2, 6, 12 and 24 months...
March 27, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28337674/painful-hashimoto-s-thyroiditis-myth-or-reality
#14
REVIEW
M Rotondi, V Capelli, P Locantore, A Pontecorvi, L Chiovato
Neck pain is a common complain, being in most cases due to non-thyroidal causes. However, a minority of patients suffer from painful thyroid diseases. Among them, sub-acute thyroiditis (SAT) is the most frequent one. Rare thyroid-related causes of neck pain include hemorrhage within a thyroid nodule as well as Riedel's thyroiditis and suppurative thyroiditis. In the last 30 years, a few cases of a painful variant of Hashimoto's thyroiditis (HT) have been described. Biochemical, ultrasound, and histologic features were clearly suggestive for HT in all of the published cases and definitely ruled out the diagnosis of SAT...
March 24, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28327620/correlation-between-ultrasound-elastography-and-histologic-characteristics-of-papillary-thyroid-carcinoma
#15
Li Yi, Wu Qiong, Wang Yan, Fan Youben, Hu Bing
The aim of this study was to investigate the correlation between elastography and histologic characteristics including fibrosis and calcification. We also wanted to investigate whether other clinicopathologic indexes influence the strain ratio (SR) of papillary thyroid carcinomas (PTCs). We retrospectively reviewed 126 papillary thyroid carcinomas (PTCs) from 103 patients who underwent ultrasonography and elastography before surgery. The histologic characteristics and clinicopathologic indexes were compared with the SR of ultrasound elastography (UE)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28323998/genes-outside-the-major-histocompatibility-complex-locus-are-linked-to-the-development-of-thyroid-autoantibodies-and-thyroiditis-in-nod-h2h4-mice
#16
Sandra M McLachlan, Sylvie Lesage, Roxanne Collin, Bianca Banuelos, Holly A Aliesky, Basil Rapoport
Thyroiditis and autoantibodies to thyroglobulin (TgAb) and thyroid peroxidase (TPOAb) develop spontaneously in NOD.H2h4 mice, a phenotype enhanced by dietary iodine. NOD.H2h4 mice were derived by introducing the major histocompatibility class (MHC) molecule I-Ak from B10.A(4R) mice to nonobese diabetic (NOD) mice. Apart from I-Ak, the genes responsible for the NOD.H2h4 phenotype are unknown. Extending serendipitous observations from crossing BALB/c to NOD.H2h4 mice, thyroid autoimmunity was investigated in both genders of the F1, F2, and the second-generation backcross of F1 to NOD...
April 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28323932/active-surveillance-for-patients-with-papillary-thyroid-microcarcinoma-a-single-center-s-experience-in-korea
#17
Hyemi Kwon, Hye-Seon Oh, Mijin Kim, Suyeon Park, Min Ji Jeon, Won Gu Kim, Won Bae Kim, Young Kee Shong, Dong Eun Song, Jung Hwan Baek, Ki-Wook Chung, Tae Yong Kim
Context: Papillary thyroid microcarcinoma (PTMC) usually has an excellent prognosis. Objective: To evaluate the 3-dimensional structures of PTMCs using serial neck ultrasonography (US) in patients under active surveillance. Design and Setting: A retrospective cohort study. Participants: In total, 192 patients diagnosed with PTMC under active surveillance for more than 1 year were included in a median 30-month follow-up...
March 3, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323630/low-thyroid-hashimoto-s-disease-and-pregnancy
#18
Jeffrey Dach
No Abstract Available.
March 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28323379/effects-of-short-term-levothyroxine-therapy-on-myocardial-injuries-in-patients-with-severe-overt-hypothyroidism-evidence-from-a-cardiac-mri-study
#19
Xia Gao, Zhe Chen, Min Liu, Yu-Mei Jia, Ning Yang, Zhi Yao, Xiao-Meng Feng, Yuan Xu, Guang Wang
PURPOSE: To investigate using magnetic resonance imaging (MRI) myocardial injuries and cardiac function in patients with newly diagnosed severe primary overt hypothyroidism (HT) before and after achieving euthyroidism by short-term levothyroxine treatment. Levothyroxine treatment improves cardiovascular performance and ventricular remodeling in patients with HT, but diffuse myocardial injuries induced by HT are difficult to detect clinically. MATERIALS AND METHODS: Myocardial longitudinal relaxation time (T1 ) mapping using the modified Look-Locker inversion-recovery (MOLLI) sequences at 3...
March 21, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28315909/a-concise-review-of-hashimoto-thyroiditis-ht-and-the-importance-of-iodine-selenium-vitamin-d-and-gluten-on-the-autoimmunity-and-dietary-management-of-ht-patients-points-that-need-more-investigation
#20
REVIEW
Michael I Liontiris, Elias E Mazokopakis
Hashimoto's thyroiditis (HT) is a chronic autoimmune thyroid disease caused by an interaction between genetic factors and environmental conditions, both of which are yet to be fully understood. The management of HT depends on its clinical manifestations, commonly including diffuse or nodular goiter with euthyroidism, subclinical hypothyroidism and permanent hypothyroidism. However, in most cases of patients with HT, lifelong levothyroxine substitution is required. The additional role of diet for the management of HT is usually overlooked...
January 2017: Hellenic Journal of Nuclear Medicine
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