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Hashimoto's Thyroiditis

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https://www.readbyqxmd.com/read/29138707/jejunojejunal-intussusception-due-to-metastatic-melanoma-seven-years-after-the-primer
#1
Alexander Giakoustidis, Thomas Goulopoulos, Anastasios Boutis, George Kavvadias, Aristidis Kainantidis, Thomas Zaraboukas, Dimitrios Giakoustidis
Intestinal intussusception in adults is a rare medical condition accounting for less than 5% of all intussusceptions. Herein we present a 45-year-old patient with a history of abdominal pain and loss of weight. CT scan revealed jejunojejunal intussusceptions. The patient was subjected to exploratory operation and small intestine resection due to a mass causing intestinal intussusception. Pathology confirmed suspected diagnosis of metastatic melanoma to small intestine secondary to melanoma, 7 years after the initial manifestation...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/29137069/graves-disease-following-radioiodine-therapy-for-toxic-adenoma-clinical-case-report
#2
Guohua Shen, Futao Cui, Rui Huang, Anren Kuang
RATIONALE: There is a low risk of developing Graves disease (GD) with elevated thyrotropin receptor antibodies (TRAbs) in patients undergoing radioiodine therapy for toxic adenoma. PATIENT CONCERNS: An old female patient with a history of Hashimoto thyroiditis was referred to our department due to thyrotoxic symptoms. After the administration of radioiodine, a significant remission was achieved. However, after 4 months, she was referred to our department again due to recurrence of hyperthyroid symptoms...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29118989/patients-with-papillary-thyroid-carcinoma-associated-with-high-stimulated-serum-calcitonin-levels
#3
Kursad Unluhizarci, Hulya Akgun, Bahadır Oz, Zuleyha Karaca, Fatih Tanriverdi, Fahrettin Kelestimur
Among various substances produced by C-cells, the most important one is calcitonin (CT) that is used for detection, post-operative follow-up and evaluation of individuals at risk of developing medullary thyroid carcinoma (MTC). However, the role of serum CT measurement in the evaluation of thyroid nodules has been widely discussed, and there is still no consensus about the role of CT in the initial evaluation of all thyroid nodules. Two patients with thyroid nodules whose fine-needle aspiration results were compatible with benign cytology besides having mildly elevated basal serum calcitonin levels were reported...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29118518/insignificant-correlation-between-thyroid-hormone-and-antithyroid-peroxidase-antibodies-in-alopecia-areata-patients-in-northern-rajasthan
#4
Gagandeep Kaur, C M Kuldeep, Puneet Bhargava, Deepak Kumar Mathur, Sonam Sharda, Pulkit Chaturvedi
Background: Alopecia areata (AA) is a common, recurrent form of nonscarring alopecia which often presents as circumscribed patches of spontaneous hair loss. The global prevalence of this disease varies from 0.1% to 0.2% in general population and 7-30 cases per 1000 dermatological patients. The etiology of AA still remains uncertain; however, genetic or environmental factor and autoimmunity are claimed responsible for it. Various autoimmune diseases, such as Hashimoto's thyroiditis, diabetes mellitus, vitiligo, and lupus erythematosus, have been reported in association with AA...
October 2017: International Journal of Trichology
https://www.readbyqxmd.com/read/29117614/the-effect-of-hypolipidemic-agents-on-thyroid-autoimmunity-in-women-with-hashimoto-s-thyroiditis-treated-with-levothyroxine-and-selenomethionine
#5
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
Background Levothyroxine and selenomethionine were found to reduce thyroid antibody titers in patients with Hashimoto's thyroiditis. The same effect was produced by intensive statin therapy. The aim of the present study was to assess whether hypolipidemic agents modulate the impact of thyroid hormone supplementation and selenomethionine on thyroid autoimmunity. Methods The study included 62 women with Hashimoto's thyroiditis treated for at least 6 months with levothyroxine and selenomethionine. On the basis of plasma lipids, women were divided into three groups: women with isolated hypercholesterolemia (group A; n=20), women with isolated hypertriglyceridemia (group B; n=17), and women with normal plasma lipids (group C; n=25)...
November 8, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29115061/carcinoma-showing-thymus-like-elements-report-of-a-case-with-egfr-t790m-mutation
#6
Madhu Rajeshwari, Varsha Singh, Aruna Nambirajan, Asit Ranjan Mridha, Deepali Jain
Carcinoma showing thymus-like differentiation of the thyroid (CASTLE) is a rare tumor involving the thyroid and perithyroidal soft tissues. It shares morphological, immunohistochemical and molecular similarities with thymic carcinomas. Due to its relatively better prognosis, it needs differentiation from other primary and metastatic tumors of this region. A 40-year-old lady presented with a gradually progressive anterior neck swelling for one year. Imaging showed bulky right and left lobes of thyroid along with a solid soft tissue mass in the pretracheal region...
November 8, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29112639/sonographic-features-of-cervical-lymph-nodes-in-patients-with-hashimoto-thyroiditis-and-the-impacts-from-the-levothyroxine-with-prednisone-therapy
#7
Guo-Rong Lyu, Wei-Kun Zheng, Wan-Ling Lin, Li-Ping Zheng, Hai-Xin Guo, Li-Ya Li
OBJECTIVE: This study aimed to evaluate the ultrasonographic pattern of cervical lymph nodes (CLNs) and whether levothyroxine with prednisone therapy is effective for lymphadenopathy in patients with Hashimoto thyroiditis (HT). METHODS: This retrospective study was looking at patients with confirmed diagnosis of HT who underwent comprehensive neck ultrasound examination. We reviewed sonographic findings in 127 patients with HT, 234 euthyroid patients with goiter, and 122 healthy subjects...
November 6, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29093307/warthin-like-papillary-thyroid-carcinoma-with-immunoglobulin-g4-positive-plasma-cells-possibly-related-to-hashimoto-s-thyroiditis
#8
Mitsuyoshi Hirokawa, Eijun Nishihara, Nami Takada, Miyoko Higuchi, Masumi Kotakemori, Toshitetsu Hayashi, Akira Miyauchi
Hashimoto's thyroiditis with heavy lymphoplasmacytic infiltration is a common comorbidity of immunoglobulin G4 (IgG4)-related thyroiditis and Warthin-like papillary thyroid carcinoma (WL-PTC). We hypothesized that WL-PTC may have a strong association with IgG4-related thyroiditis. To validate this hypothesis, we clinically and immunohistochemically studied 17 WL-PTC cases. Fourteen patients (82.4%) had anti-thyroglobulin antibody and were confirmed to have Hashimoto's thyroiditis through microscopic analysis...
November 2, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29083503/risk-factors-stratifying-malignancy-of-nodules-in-contralateral-thyroid-lobe-in-patients-with-preoperative-ultrasound-indicated-unilateral-papillary-thyroid-carcinoma-a-retrospective-analysis-from-single-center
#9
Tian Lv, Changbin Zhu, Zhongming Di
OBJECTIVE: Papillary thyroid carcinoma (PTC) is the most common thyroid carcinoma with a favorable clinical outcome. For unilateral PTC patients with thyroid nodules in the contralateral lobes, the necessity of total thyroidectomy (TT) is still in doubt. In this study, we aimed to define clinical factors that could be indicators for malignancy in nodules in the contralateral thyroid lobe, which could aid the clinician in selecting the appropriate operation approach. DESIGN, PATIENTS AND MEASUREMENTS: This is a retrospective study from Jan 2014 to Dec 2016 conducted in Shanghai Ruijin Hospital...
October 30, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/29071236/performance-and-specificity-of-6-immunoassays-for-tsh-receptor-antibodies-a-multicenter-study
#10
Tanja Diana, Christian Wüster, Paul D Olivo, Angelica Unterrainer, Jochem König, Michael Kanitz, Artur Bossowski, Brigitte Decallonne, George J Kahaly
BACKGROUND: The measurement of TSH receptor (TSHR) antibodies is warranted for diagnosis of Graves' disease (GD). OBJECTIVE: The performance, detection sensitivity, and specificity of 6 TSHR immunoassays were compared. METHODS: Two bioassays and 4 binding assays (Kronus, Immulite, Kryptor, Dynex) were compared in a dilution study performed in patients with autoimmune thyroid disease. Both bioassays were compared to 2 binding assays using stimulatory (M22) and blocking (K1-70) monoclonal antibody (MAb) mixtures...
September 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/29067257/a-study-of-serum-igg4-levels-in-the-clinical-metamorphosis-of-autoimmune-thyroid-disease
#11
Yotsapon Thewjitcharoen, Sirinate Krittiyawong, Sriurai Porramatikul, Ekgaluck Wanothayaroj, Nampetch Lekpittaya, Jirapat Jeamjiraprasert, Soontaree Nakasatien, Thep Himathongkam
BACKGROUND: Measurement of serum IgG4 had been suggested to distinguish the unique subtypes of autoimmune thyroid disease (AITD) which demonstrated patterns of fluctuating between hyperthyroidism and hypothyroidism. However, the clinical utility of serum IgG4 measurement is inconclusive due to few studies having addressed these unusual patients compared with the specificity of serum IgG4 in healthy patients. AIM: To investigate whether elevated serum IgG4 levels could be used as a marker to identify fluctuating AITD patients...
June 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29066479/eosinophil-cationic-protein-in-patients-with-differentiated-thyroid-cancer-treated-with-radioactive-iodine-131
#12
Snezana Zivancevic-Simonovic, Olgica Mihaljevic, Irena Kostic, Nevenka Ilic, Dusan Mihajlovic, Dragan Vasiljevic, Ljiljana Mijatovic-Teodorovic, Svetlana Miletic-Drakulic, Miodrag Colic
Published data indicate the involvement of eosinophil granulocytes and eosinophil cationic protein (ECP) in tumor defense. The aim of this study was to analyze serum ECP concentrations in patients with differentiated thyroid cancer (DTC) before, 3 days and 7 days after radioactive iodine (131-I) therapy. Association of ECP concentrations with histological type of tumor, stage of disease and/or levels of selected T-helper 2 (Th2) cytokines was examined. The study population included 17 DTC patients and 10 control subjects...
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29064805/-key-minerals-significant-for-hypothyroidism-including-hashimoto-s-thyroiditis-function-and-presence-in-food
#13
Anna Kowalczyk, Magdalena Zegan, Ewa Michota-Katulska
Thyroid diseases belong to the most common disorders of the ductless glands. Particular attention is paid to the growing morbidity of autoimmune affliction of the thyroid gland, including Hashimoto's thyroiditis. The main method of treatment is an oral substitution of thyroid hormones. However, the literature pays particular attention to supporting therapy with a diet rich in components essential for the proper functioning of this organ.
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29064111/acoustic-radiation-force-impulse-quantification-in-the-evaluation-of-thyroid-elasticity-in-pediatric-patients-with-hashimoto-thyroiditis
#14
Serap Yucel, Meltem Ceyhan Bilgici, Cengiz Kara, Gulay Can Yilmaz, H Murat Aydin, Muzaffer Elmali, Leman Tomak, Dilek Saglam
OBJECTIVES: To evaluate the parenchymal elasticity of the thyroid gland with acoustic radiation force impulse imaging in pediatric patients with Hashimoto thyroiditis and to compare it with healthy volunteers. METHODS: Twenty-six patients with Hashimoto thyroiditis and 26 healthy volunteers between 6 and 17 years were included. The shear wave velocity (SWV) values of both thyroid lobes in both groups were evaluated. RESULTS: The age and sex characteristics of the controls and patients with Hashimoto thyroiditis were similar...
October 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29058491/a-review-of-primary-thyroid-lymphoma-molecular-factors-diagnosis-and-management
#15
Efstathios T Pavlidis, Theodoros E Pavlidis
Purpose/aim: To focus on current aspects of primary thyroid lymphoma (PTL), which is a rare clinical entity usually manifested by a rapidly growing mass in the neck that can cause pressure symptoms. MATERIALS AND METHODS: Relevant papers in PubMed published through June 2017 were selected to track updated information about PTL with an emphasis on diagnosis and novel therapeutic management. RESULTS: The most frequent cases include non-Hodgkin lymphoma derived from B-cells, mainly diffuse large B-cell lymphoma (DLBCL) followed by mucosa-associated lymphoid tissue (MALT) lymphoma or a mixed type...
October 23, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29055566/serum-interleukin-6-levels-are-increased-in-hiv-infected-patients-that-develop-autoimmune-disease-during-long-term-follow-up
#16
M Trovato, R M Ruggeri, S Sciacchitano, T M Vicchio, I Picerno, G Pellicanò, A Valenti, G Visalli
BACKGROUND: Elevated IL-6 levels have been associated with both autoimmune diseases and treated HIV-seropositive (HIV(+)) subjects. However, few data on classic and trans-signaling IL-6 in autoimmune thyroid diseases and HIV(+) subjects developing autoimmune disorders are currently available. MATERIALS AND METHODS: A total of 102 patients were included in the study. They were subdivided into two groups. Group A consisted in 51 HIV(+) patients, who were followed-up for a period of five years in search of possible occurrence of autoimmune diseases...
October 16, 2017: Immunobiology
https://www.readbyqxmd.com/read/29054761/differential-expression-levels-of-plasma-microrna-in-hashimoto-s-disease
#17
Lijuan Zhao, Xin Zhou, Xia Shan, Lian-Wen Qi, Tongshan Wang, Jun Zhu, Danxia Zhu, Zebo Huang, Lan Zhang, Huo Zhang, Yin Yin, Zhiyan Wang, Wei Zhu, Wenfang Cheng, Lin Jiang
BACKGROUND: The altered expression of circulating miRNAs has been discovered in many autoimmune diseases (ADs). With rare existing research, it is still unclear in Hashimoto's thyroiditis (HT). We detected plasma miRNA expression of HT patients in this three-stage designed study. METHODS: Differently expressed miRNAs (4 HT pools vs. 1 normal control pool) were identified using quantitative reverse transcription polymerase chain reaction (qRT-PCR) based Exiqon panel (miRCURY-Ready-to-Use- PCR-Human- panel-I+II-V1...
October 17, 2017: Gene
https://www.readbyqxmd.com/read/29050166/-clinic-pathological-and-ultrasonographic-features-of-primary-thyroid-lymphoma
#18
X M Zhang, L Nong, X Ran, M Li
Objective: To analyze the ultrasonographic and clinicopathological features of primary thyroid lymphoma(PTL). Methods: The ultrasonographic and clinicopathological featuresof 21 cases of pathologically-confirmed PTLs were analyzed retrospectively. Results: Of all 21 PTLs, 15 cases were diffuse large B-cell lymphoma, 4 were mucosal-associated lymphoid tissue extranodular marginal zone B-cell lymphoma, 1 was small B-cell lymphoma and 1 was classical Hodgkin lymphoma. Eight cases were proved by pathology with concomitant Hashimoto's thyroiditis...
October 10, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29044769/human-papillomavirus-vaccination-of-adult-women-and-risk-of-autoimmune-and-neurological-diseases
#19
A Hviid, H Svanström, N M Scheller, O Grönlund, B Pasternak, L Arnheim-Dahlström
BACKGROUND: Since 2006, human papillomavirus (HPV) vaccines have been introduced in many countries worldwide. Whilst safety studies have been reassuring, focus has been on the primary target group, the young adolescent girls. However, it is also important to evaluate safety in adult women where background disease rates and safety issues could differ significantly. OBJECTIVE: We took advantage of the unique Danish and Swedish nationwide healthcare registers to conduct a cohort study comparing incidence rate ratios (RRs) of 45 preselected serious chronic diseases in quadrivalent HPV (qHPV)-vaccinated and qHPV-unvaccinated adult women 18-44 years of age...
October 18, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29042997/cd19-cd24-hi-cd38-hi-regulatory-b-cells-are-associated-with-insulin-resistance-in-type-i-hashimoto-s-thyroiditis-in-chinese-females
#20
Min Yang, Changji Du, Yinping Wang, Jun Liu
Hashimoto's thyroiditis (HT) is typically associated with insulin resistance. The aim of the present study was to investigate the role of regulatory B cells (Bregs) in insulin resistance in patients with HT. A total of 52 female patients with type I HT and 35 matched healthy volunteers were enrolled. Demographic and laboratorial data were collected. A 75 g oral glucose tolerance test was performed on each subject. Flow cytometry was performed to evaluate the levels of CD19(+)CD24(hi)CD38(hi) Bregs in peripheral blood...
October 2017: Experimental and Therapeutic Medicine
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