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https://www.readbyqxmd.com/read/28515051/views-of-women-with-polycystic-ovary-syndrome-a-qualitative-study-in-an-ethnically-diverse-sample
#1
Michelle Hadjiconstantinou, Hamidreza Mani, Naina Patel, Miles Levy, Melanie J Davies, Kamlesh Khunti, Margaret Stone
OBJECTIVE: Polycystic ovary syndrome (PCOS) is a lifelong condition. Its symptoms have been linked with psychological consequences, but less attention has been given to the daily implications of living with PCOS. We aimed to explore women's experiences living with PCOS, and the potential acceptability of group education sessions for this target group. METHODS: Women with PCOS were recruited from an ethnically diverse UK community. Twelve semi-structured interviews were conducted...
May 17, 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28507858/reconstructing-discontinuous-facial-defects-with-simultaneous-ulnar-perforator-free-flaps
#2
Carissa M Thomas, Mofiyinfolu Sokoya, Frederic W-B Deleyiannis
Multiple, simultaneous skin cancers of the face are common. This is the first description of reconstructing discontinuous facial defects (i.e., separate sites of the face) with simultaneous ulnar perforator flaps. The distinct innovations of this multiple flap design are the ability to restrict the harvest site to one extremity, to obtain vein and arterial grafts from the same extremity, and to create multiple flaps with minimal hirsutism and bulk. We present a case of a 57-year-old male with multiple basal cell carcinomas who underwent wide local excisions of the right upper lip and cheek and of the left lower eyelid and infraorbital cheek...
April 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28492053/association-of-ethnicity-fitzpatrick-skin-type-and-hirsutism-a-retrospective-cross-sectional-study-of-women-with-polycystic-ovarian-syndrome
#3
L Afifi, L Saeed, L A Pasch, H G Huddleston, M I Cedars, L T Zane, K Shinkai
BACKGROUND: The complex interplay between ethnicity, Fitzpatrick skin type (FST), and hirsutism in patients with polycystic ovarian syndrome (PCOS) is poorly understood. OBJECTIVE: In this cross-sectional, retrospective analysis, we examined the prevalence, severity, and distribution of hirsutism with clinician-rated site-specific and total modified Ferriman-Gallwey (mFG) visual scoring in a diverse cohort of American patients with PCOS. METHODS: Independent analyses were conducted on the basis of patient-reported FST ratings and ethnicity...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28492032/endocrine-evaluation-of-hirsutism
#4
REVIEW
John Mihailidis, Racha Dermesropian, Pamela Taxel, Pooja Luthra, Jane M Grant-Kels
Hirsutism is defined as excessive terminal hair growth in a male pattern in females. It typically affects 5 to 10% of reproductive-age women. Excessive hair growth can often cause significant psychological and emotional distress. As a result, hirsutism is a common presenting complaint to healthcare professionals, including dermatologists, as women search for cosmetic and medical solutions to their problem. Hirsutism results from excess production of androgens, often from ovarian or adrenal sources. It is typically associated with a metabolic syndrome like polycystic ovarian syndrome (PCOS), but can be idiopathic or medication-induced...
March 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28486593/prevalence-of-obesity-associated-gonadal-dysfunction-in-severely-obese-men-and-women-and-its-resolution-after-bariatric-surgery-a-systematic-review-and-meta-analysis
#5
Hector F Escobar-Morreale, Elisa Santacruz, Manuel Luque-Ramírez, José I Botella Carretero
BACKGROUND: Sexual dimorphism manifests noticeably in obesity-associated gonadal dysfunction. In women, obesity is associated with androgen excess disorders, mostly the polycystic ovary syndrome (PCOS), whereas androgen deficiency is frequently present in obese men in what has been termed as male obesity-associated secondary hypogonadism (MOSH). Obesity-associated gonadal dysfunction, consisting of PCOS in women and MOSH in men, is a frequent finding in patients with severe obesity and it may be ameliorated or even resolve with marked weight loss, especially after bariatric surgery...
May 9, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28472487/11-oxygenated-androgens-are-biomarkers-of-adrenal-volume-and-testicular-adrenal-rest-tumors-in-21-hydroxylase-deficiency
#6
Adina F Turcu, Ashwini Mallappa, Meredith Elman, Nilo A Avila, Jamie Marko, Hamsini Rao, Alexander Tsodikov, Richard J Auchus, Deborah P Merke
Context: Patients with 21-hydroxylase deficiency (21OHD) suffer from long-term complications, which might result from poor disease control and/or glucocorticoid overtreatment. Lack of optimal biomarkers has made it challenging to tailor therapy and to predict long-term outcomes. Objective: To identify biomarkers of disease control and long-term complications in 21OHD. Setting and participants: Cross-sectional study of 114 patients (70 males), ages 2 to 67 (median, 15) years, seen in a tertiary referral center...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28463030/use-of-cyproterone-acetate-ethinylestradiol-in-polycystic-ovary-syndrome-rationale-and-practical-aspects
#7
X Ruan, A Kubba, A Aguilar, A O Mueck
INTRODUCTION: Polycystic ovary syndrome (PCOS) is a common, heterogeneous disorder characterised by hyperandrogenic skin symptoms, irregular menstruation and subfertility, increased risk of endometrial malignancy, and increased risk of preventable diseases associated with metabolic syndrome. Cyproterone acetate (CPA) 2 mg, combined with ethinylestradiol (EE) 35 μg, is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age...
May 2, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28456695/paratubal-cyst-size-correlates-with-obesity-and-dysregulation-of-the-wnt-signaling-pathway
#8
Jennifer E Dietrich, Oluyemisi Adeyemi, Julie Hakim, Xiomara Santos, Jennifer L Bercaw-Pratt, Juan C Bournat, Ching H Chen, Carolina J Jorgez
BACKGROUND: Paratubal cysts (PTC) occur in 7-10% of females, regardless of ages. Although common, PTCs often are found incidentally because of the potential for these cysts to be asymptomatic. SPECIFIC AIMS: To determine if PTC number and size correlated with signs of hyperandrogenism and obesity, as well as to investigate the molecular profiles of these PTCs in samples derived from adolescent females. METHODS: A prospective cohort study was performed in a single children's hospital...
April 26, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28455078/sexual-function-in-infertile-women-with-polycystic-ovary-syndrome-and-unexplained-infertility
#9
Michael P Diamond, Richard S Legro, Christos Coutifaris, Ruben Alvero, Randal D Robinson, Peter A Casson, Gregory M Christman, Hao Huang, Karl R Hansen, Valerie Baker, Rebecca Usadi, Aimee Seungdamrong, G Wright Bates, R Mitchell Rosen, William Schlaff, Daniel Haisenleder, Stephen A Krawetz, Kurt Barnhart, J C Trussell, Nanette Santoro, Esther Eisenberg, Heping Zhang
BACKGROUND: While female sexual dysfunction is a frequent occurrence, characteristics in infertile women are not well delineated. Furthermore, the impact of infertility etiology on the characteristics in women with differing androgen levels observed in women with polycystic ovary syndrome and unexplained infertility has not been assessed. OBJECTIVE: To determine the characteristics of sexual dysfunction in women with polycystic ovary syndrome and unexplained infertility...
April 25, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28450335/books-the-10-minute-clincial-assessment-a-systematic-and-easy-to-follow-guide-from-hirsutism-to-heart-failure-to-self-harm
#10
Hajira Dambha-Miller
No abstract text is available yet for this article.
May 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28450075/congenital-adrenal-hyperplasia
#11
REVIEW
Selma Feldman Witchel
The congenital adrenal hyperplasias (CAH) comprise a family of autosomal recessive disorders that disrupt adrenal steroidogenesis. The most common form is due to21-hydroxylase deficiency associated with mutations in the CYP21A2 gene which is located at chromosome 6p21. The clinical features associated with each disorder of adrenal steroidogenesis represent a clinical spectrum reflecting the consequences of the specific mutations. Treatment goals include normal linear growth velocity and "on-time" puberty in affected children...
April 24, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28447864/the-use-of-cyproterone-acetate-ethinyl-estradiol-in-hyperandrogenic-skin-symptoms-a-review
#12
J Bitzer, T Römer, A Lopes da Silva Filho
INTRODUCTION: Hyperandrogenism affects approximately 10-20% of women of reproductive age. Hyperandrogenic skin symptoms such as hirsutism, acne, seborrhea and alopecia are associated with significant quality of life and psychological impairment. Women with abnormalities in androgen metabolism may have accompanying anovulation and/or polycystic ovary syndrome (PCOS), both of which have reproductive and metabolic implications if left untreated. Cyproterone acetate (CPA), combined with ethinylestradiol (EE), is indicated for the treatment of moderate to severe acne related to androgen-sensitivity (with or without seborrhea) and/or hirsutism, in women of reproductive age...
April 27, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28439055/-calcium-and-bone-metabolism-across-women-s-life-stages-bone-metabolism-and-estrogen-androgen-balance-in-women
#13
Toshiyuki Yasui, Miwa Fukuoka
Androgen as well as estrogen has physical, psychological and sexual roles in women. The action of androgen on bone health in women is important. The androgen receptor is expressed in osteoblasts and osteocytes but the mechanism has not been clarified in women. It has been reported that endogenous testosterone level was positively correlated with bone mineral density and higher testosterone level might be associated with decrease in bone fractures. Also, it has been reported that bone mineral density in women who received testosterone with estrogen was higher than that in women who received estrogen alone...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28420905/effects-of-supervised-aerobic-training-on-the-levels-of-anti-mullerian-hormone-and-adiposity-measures-in-women-with-normo-ovulatory-and-polycystic-ovary-syndrome
#14
Einas Al-Eisa, Sami Ali Gabr, Ahmad Hieder Alghadir
OBJECTIVE: To evaluate the change in the levels of anti-Mullerian hormone, adiponectin, weight loss and fertility parameters in obese women with or without polycystic ovary syndrome, following 12 weeks of supervised aerobic exercise. METHODS: This study was conducted from August 2013 to October 2014 among obese women with or without polycystic ovary syndrome referred to Obstetrics and Gynecology clinic, Mansoura University Hospital, Faculty of Medicine, Mansoura, Egypt...
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28413388/a-case-report-of-cushing-s-disease-presenting-as-hair-loss
#15
Emily G Lefkowitz, Jack P Cossman, John B Fournier
Cushing's syndrome is a rare endocrine disorder that comprises a large group of signs and symptoms resulting from chronic exposure to excess corticosteroids. Most cases of Cushing's syndrome are due to increased adrenocorticotropic hormone production from a pituitary adenoma, which is referred to as Cushing's disease. Most of the signs and symptoms are nonspecific and common in the general population, making a diagnosis often challenging. However, several dermatological manifestations, such as fragile skin, easy bruising, and reddish purple striae, are more discriminatory...
January 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28405549/cutaneous-manifestations-of-polycystic-ovary-syndrome-a-cross-sectional-clinical-study
#16
Mohammad Abid Keen, Iffat Hassan Shah, Gousia Sheikh
BACKGROUND: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women, affecting 5-10% of reproductive-aged women. The dermatologic manifestations of hyperandrogenism, chiefly hirsutism, acne vulgaris, androgenic alopecia, and acanthosis nigricans, are among the cardinal manifestations of PCOS. AIM: To study the incidence and prevalence of various cutaneous manifestations in patients with PCOS and to correlate these skin manifestations with hormonal changes...
March 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28385785/imatinib-and-spironolactone-suppress-hepcidin-expression
#17
Katarzyna Mleczko-Sanecka, Ana Rita da Silva, Debora Call, Joana Neves, Nikolai Schmeer, Georg Damm, Daniel Seehofer, Martina U Muckenthaler
Disorders of iron metabolism are largely attributed to an excessive or insufficient expression of hepcidin, the master regulator of systemic iron homeostasis. Here, we investigated whether drugs targeting genetic regulators of hepcidin can affect iron homeostasis. We focused our efforts on drugs approved for clinical use to enable repositioning strategies and/or to reveal iron-related side effects of widely prescribed therapeutics. To identify hepcidin-modulating therapeutics, we reevaluated data generated by a genome-wide RNAi screen for hepcidin regulators...
April 6, 2017: Haematologica
https://www.readbyqxmd.com/read/28385114/psychological-distress-anger-and-quality-of-life-in-polycystic-ovary-syndrome-associations-with-biochemical-phenotypical-andsocio-demographic-factors
#18
Lidia Borghi, Daniela Leone, Elena Vegni, Valentina Galiano, Corina Lepadatu, Patrizia Sulpizio, Emanuele Garzia
OBJECTIVE: To investigate the association between polycystic ovary syndrome (PCOS) and psychological disturbances, including anger. To analyze whether the biochemical/phenotypical features of PCOS play a role in the type and severity of psychological disorders. MATERIAL AND METHODS: This case-control study included 30 PCOS patients meeting NIH criteria and 30 non-PCOS women referring to Reproductive Medicine Unit for infertility. Complete clinical and biochemical screening and the self-reported psychological data [Symptom Check List 90-R (SCL-90-R); Short-Form Health Survey 36 (SF-36); and State-Trait Anger Expression Inventory-2 (STAXI-2)] were collected...
April 6, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28383189/maternal-hirsutism-and-autism-spectrum-disorders-in-offspring
#19
Brian K Lee, Stefan Arver, Linnea Widman, Renee M Gardner, Cecilia Magnusson, Christina Dalman, Kyriaki Kosidou
Because animal and human studies indicate that androgen exposure can influence neurodevelopment, it has been hypothesized that prenatal exposure to excess androgens may predispose to disorders with male-skewed ratio such as autism spectrum disorders (ASD). Therefore, maternal conditions characterized by hyperandrogenism such as polycystic ovary syndrome (PCOS) or hirsutism may be relevant to child ASD. We previously found in a large Swedish case-control study of 23,748 ASD cases and 208,796 matched controls that PCOS in mothers is associated with increased offspring risk of ASD...
April 6, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/28379593/flutamide-induced-hepatotoxicity-ethical-and-scientific-issues
#20
R Giorgetti, M di Muzio, A Giorgetti, D Girolami, L Borgia, A Tagliabracci
OBJECTIVE: Flutamide (FLU) is a non-steroidal antiandrogen drug approved for the treatment of advanced prostate cancer. While this indication limits the use to male patients, FLU is widely prescribed to women, off-label, for the treatment of polycystic ovary syndrome (POCS) related hirsutism and acne. According to the literature, its assumption is associated with a higher incidence of adverse events in women than in male patients. MATERIALS AND METHODS: A literature search was conducted in main databases targeting unwilling FLU effects in hepatic and reproductive function...
March 2017: European Review for Medical and Pharmacological Sciences
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