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https://www.readbyqxmd.com/read/29463075/adverse-effects-of-doping-with-anabolic-androgenic-steroids-aas-in-competitive-athletics-recreational-sports-and-bodybuilding
#1
Elena Vorona, Eberhard Nieschlag
Despite the fact that sports organizations and legislators have introduced various mechanisms to discourage athletes from using performance and appearance enhancing substances a high percentage of athletes admits to their unabated application. In competitive athletics, bodybuilding and in recreational sports anabolic androgenic steroids (AAS) continue to be the substances most abused. This review summarizes the side effects of AAS abuse on organs and system functions in both sexes. High doses of AAS cause a significant increase of erythrocytes und haemoglobin concentration, which may lead to thromboembolism, intracardiac thrombosis and stroke...
February 19, 2018: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29462707/the-diagnostic-value-of-anti-mullerian-hormone-in-early-post-menarche-adolescent-girls-with-polycystic-ovarian-syndrome
#2
Pınar Kocaay, Zeynep Siklar, Sema Buyukfirat, Merih Berberoglu
STUDY OBJECTIVE: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by hyperandrogenism and chronic anovulation, which affects 5-10% of reproductive age females. Diagnosis of adult patients with PCOS is made easily with clinical and laboratory methods and the antimullerian hormone (AMH) level are accepted as a good indicator. However, there is still no complete consensus on the diagnosis of PCOS in adolescents. DESIGN: and Settings: Prospective cohort study, December 2013 to November 2014 PARTICIPANTS: The study was conducted on adolescent girls with oligomenorrhea, with at least two years since menarche...
February 17, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29460643/para-ovarian-adrenal-rest-tumors-gynecologic-manifestations-of-untreated-congenital-adrenal-hyperplasia
#3
Jessica M Sisto, Fong W Liu, Mitchell E Geffner, Michael L Berman
Congenital adrenal hyperplasia (CAH) is an inherited disorder of adrenal steroidogenesis often diagnosed in infancy. Gynecologists may encounter adult patients with CAH due to the clinical effects of increased androgens, e.g. hirsutism, clitoromegaly, oligomenorrhea, or, rarely, pelvic masses. This case report reviews the association of para-ovarian adrenal rest tumors with CAH, and the role of gynecologists in their evaluation and treatment. A 23-year-old woman with CAH (21-hydroxyase deficiency) untreated for the past 5 years presented with a pelvic mass and elevated serum testosterone (1433 ng/dL) and plasma ACTH (1117 pg/mL)...
February 20, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29457756/effects-of-combined-oral-contraceptives-on-the-clinical-and-biochemical-parameters-of-hyperandrogenism-in-patients-with-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#4
Mina Amiri, Ali Kabir, Fatemeh Nahidi, Maryam Shekofteh, Fahimeh Ramezani Tehrani
INTRODUCTION: Nowadays, selection of COCs with maximum antiandrogenic effects is one the main issues in treatment of women with polycystic ovary syndrome (PCOS). OBJECTIVE: This systematic review and meta-analysis aimed to compare the effects of COCs on the clinical and biochemical parameters of hyperandrogenism (HA) in patients with PCOS. METHODS: Electronic databases (PubMed, Scopus, ScienceDirect and web of science) were searched from 1987 to November 2015 to identify clinical trials investigating effect of the various COCs on the clinical and biochemical parameters of HA in patients...
February 19, 2018: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/29440921/adult-onset-acne-prevalence-impact-and-management-challenges
#5
REVIEW
Marco A Rocha, Ediléia Bagatin
Acne is a multifactorial and inflammatory disease of pilosebaceous follicles, which affects most adolescents. Recent epidemiological data revealed a difference in adults affected by this disease. Women have a high prevalence and incidence when compared with men, especially after 25 years of age. In contrast to what was initially thought, most of these patients do not present endocrinopathy capable of leading to the development of the lesions. When present, polycystic ovarian syndrome is the main cause. However, in these cases, acne is rarely the only dermatological manifestation; hirsutism and acanthosis nigricans are often present...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29419804/alpha-difluoromethylornithine-an-irreversible-inhibitor-of-polyamine-biosynthesis-as-a-therapeutic-strategy-against-hyperproliferative-and-infectious-diseases
#6
REVIEW
Nicole LoGiudice, Linh Le, Irene Abuan, Yvette Leizorek, Sigrid C Roberts
The fluorinated ornithine analog α-difluoromethylornithine (DFMO, eflornithine, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase (ODC), the first and rate-limiting enzyme of polyamine biosynthesis. The ubiquitous and essential polyamines have many functions, but are primarily important for rapidly proliferating cells. Thus, ODC is potentially a drug target for any disease state where rapid growth is a key process leading to pathology. The compound was originally discovered as an anticancer drug, but its effectiveness was disappointing...
February 8, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29410349/non-targeted-profiling-of-circulating-micrornas-in-women-with-polycystic-ovary-syndrome-pcos-effects-of-obesity-and-sex-hormones
#7
Mora Murri, María Insenser, Elena Fernández-Durán, José L San-Millán, Manuel Luque-Ramírez, Héctor F Escobar-Morreale
PURPOSE: Circulating micro-ribonucleic acids (miRNAs) are small noncoding RNA molecules that influence gene transcription. We conducted the present profiling study to characterize the expression of circulating miRNAs in lean and obese patients with polycystic ovary syndrome (PCOS), the most common endocrine and metabolic disorder in premenopausal women. BASIC PROCEDURES: We selected 11 control women, 12 patients with PCOS and 12 men so that they were similar in terms of body mass index...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29408736/diagnostic-evaluation-comorbidity-screening-and-treatment-of-polycystic-ovary-syndrome-in-adolescents-in-three-specialty-clinics
#8
Meghna R Sebastian, Constance M Wiemann, Fida Bacha, Sharonda J Alston-Taylor
STUDY OBJECTIVE: A polycystic ovary syndrome (PCOS) diagnosis in adolescence can have significant long-term health implications. The criteria for its diagnosis in adolescents have been subject to much debate. This study aimed to characterize the variability in diagnosis and management among different pediatric specialties. DESIGN, SETTINGS, PARTICIPANTS, AND INTERVENTIONS: This is a retrospective review of electronic medical records of females (11 - 21 years old) who presented to three specialties (adolescent medicine (AM), pediatric endocrinology (ENDO), and gynecology (GYN)), with a post-visit diagnosis of PCOS, menstrual disorders, or hirsutism, at a large tertiary care center, from November 1, 2011- October 31, 2012...
January 31, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29383563/homology-modeling-of-5-alpha-reductase-2-using-available-experimental-data
#9
Jamal Shamsara
5-Alpha-reductase 2 is an interesting pharmaceutical target for the treatment of several diseases, including prostate cancer, benign prostatic hyperplasia, male pattern baldness, acne, and hirsutism. One of the main approaches in computer aided drug design is structure-based drug discovery. However, the experimental 3D structure of 5-alpha-reductase 2 is not available at present. Therefore, a homology modeling method and molecular dynamics simulation were used to develop a reliable model of 5-alpha-reductase 2 for inhibitor pose prediction and virtual screening...
January 30, 2018: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/29377293/a-study-of-androgenic-signs-and-disorders-in-greek-female-patients-with-acne
#10
Clio Dessinioti, Vassiliki Tzanetakou, Chrisa Zisimou, Eftychia Platsidaki, Eftychia Koukkou, Andreas Katsambas, Christina Antoniou
Acne represents an established cutaneous manifestation of hyperandrogenism (1). There are scarce studies of androgenic signs or disorders including polycystic ovary syndrome (PCOS), hirsutism, menstrual irregularities or androgenic alopecia, in patients with acne. This article is protected by copyright. All rights reserved.
January 29, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29370410/gut-microbial-diversity-in-women-with-polycystic-ovary-syndrome-correlates-with-hyperandrogenism
#11
Pedro J Torres, Martyna Siakowska, Beata Banaszewska, Leszek Pawelczyk, Antoni J Duleba, Scott T Kelley, Varykina G Thackray
Context: A majority of women with polycystic ovary syndrome (PCOS) have metabolic abnormalities that result in an increased risk of developing type 2 diabetes and heart disease. Correlative studies have shown an association between changes in the gut microbiome and metabolic disorders. Two recent studies reported a decrease in alpha diversity of the gut microbiome in women with PCOS compared with healthy women. Objective: We investigated whether changes in the gut microbiome correlated with specific clinical parameters in women with PCOS compared to healthy women...
January 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29363047/new-perspectives-on-the-definition-and-management-of-polycystic-ovary-syndrome
#12
REVIEW
R Pasquali, A Gambineri
BACKGROUND: There is a growing debate on the opportunity of improving the understanding in the diagnosis and management of polycystic ovary syndrome (PCOS). OBJECTIVE: This review article summarizes recent research related to the definition of polycystic ovary syndrome (PCOS). METHODS: Review of the recent literature on the topic. RESULTS: New ideas on the definition of hyperandrogenism, based on new scientific data and clinical perspectives are presented...
January 23, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29352423/understanding-and-addressing-hair-disorders-in-transgender-individuals
#13
REVIEW
Yi Gao, Toby Maurer, Paradi Mirmirani
In the United States, an increasing number of individuals are identifying as transgender. Males at birth who identify as females are called male-to-female (MTF) transgender individuals or trans women, and females at birth who identify as males are called female-to-male (FTM) transgender individuals or trans men. The transgender patient population possess unique health concerns disparate from those of the general populace. Exogenous hormone therapy for transgender patients leads to changes in the distribution and pattern of hair growth...
January 19, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29327931/bastimolide-b-an-antimalarial-24-membered-marine-macrolide-possessing-a-tert-butyl-group
#14
Chang-Lun Shao, Xiao-Feng Mou, Fei Cao, Carmenza Spadafora, Evgenia Glukhov, Lena Gerwick, Chang-Yun Wang, William H Gerwick
We reported previously the discovery of the potent antimalarial 40-membered macrolide bastimolide A (1) from the tropical marine cyanobacterium Okeania hirsute. Continued investigation has led to the discovery of a new analogue, bastimolide B (2), a 24-membered polyhydroxy macrolide with a long aliphatic chain and unique terminal tert-butyl group. Its complete structure was determined by a combination of extensive spectroscopic methods and comparative analysis of its methanolysis products with those of bastimolide A...
January 12, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29327300/cant%C3%A3%C2%BA-syndrome-with-coexisting-familial-pituitary-adenoma
#15
Pedro Marques, Rupert Spencer, Patrick J Morrison, Ian M Carr, Mary N Dang, David T Bonthron, Steven Hunter, Márta Korbonits
CONTEXT: Pseudoacromegaly describes conditions with an acromegaly related physical appearance without abnormalities in the growth hormone (GH) axis. Acromegaloid facies, together with hypertrichosis, are typical manifestations of Cantú syndrome. CASE DESCRIPTION: We present a three-generation family with 5 affected members, with marked acromegaloid facies and prominent hypertrichosis, due to a novel missense variant in the ABCC9 gene. The proband, a 2-year-old girl, was referred due to marked hypertrichosis, noticed soon after birth, associated with coarsening of her facial appearance...
January 11, 2018: Endocrine
https://www.readbyqxmd.com/read/29320974/head-to-head-comparison-of-adverse-effects-and-efficacy-between-high-dose-deflazacort-and-high-dose-prednisolone-in-systemic-lupus-erythematosus-a-prospective-cohort-study
#16
A Ganapati, R Ravindran, T David, B Yadav, V Jeyaseelan, L Jeyaseelan, D Danda
Background Deflazacort (DFZ), an oxazoline derivative of prednisolone (PDN), has a dose equivalence of 1.2:1 (mg) to PDN. No study to date has compared adverse effects and efficacy of high doses of DFZ as against high-dose PDN in systemic lupus erythematosus (SLE). Objectives To compare adverse effects of high dose DFZ and PDN in SLE patients, especially in terms of cushingoid features and gain in body weight, 3 and 6 months after initiation of these agents. Methods In both the steroid arms, the following outcome parameters were assessed at 3 and 6 months: (a) cushingoid features by Cushing's Severity Index (CSI) (b) hirsutism by modified Ferriman Gallwey score (c) weight gain by difference (Δ, delta) of weight (in kilograms)...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29283210/ube2a-deficiency-in-two-siblings-a-novel-splicing-variant-inherited-from-a-maternal-germline-mosaicism
#17
Teresa Giugliano, Claudia Santoro, Annalaura Torella, Francesca Del Vecchio Blanco, Pia Bernardo, Vincenzo Nigro, Giulio Piluso
UBE2A deficiency is a syndromic condition of X-linked intellectual disability (ID) characterized by typical dysmorphic features that include synophrys, prominent supraorbital ridges, almond-shaped, and deep-set eyes, large ears, wide mouth, myxedematous appearance, hirsutism, micropenis, and onychodystrophy. To date, only seven familial UBE2A intragenic mutations and nine larger microdeletions encompassing UBE2A have been reported. Here, we describe two siblings with X-linked ID and typical clinical features of UBE2A deficiency caused by a novel hemizygous variant, identified by massively parallel sequencing of X-exome...
December 28, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29280221/what-is-adolescent-polycystic-ovary-syndrome
#18
REVIEW
Alexia S Peña, Michael Metz
The diagnostic criteria for adolescent polycystic ovary syndrome (PCOS) has been derived from adult criteria, which makes diagnosis challenging as criteria include normal physiological events that occur during puberty such as acne, hirsutism, menstrual irregularities, high androgen levels and polycystic ovarian morphology on pelvic ultrasound. The only criteria that applies from the adult criteria is exclusion of other conditions that mimic PCOS. Clinical findings consistent with hyperandrogenaemia during adolescence include inflammatory acne, hirsutism, alopecia and/or menstrual irregularities, which are severe and present 2 years after menarche...
December 27, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29258367/evaluation-of-prolonged-use-of-statins-on-the-clinical-and-biochemical-abnormalities-and-ovulation-dysfunction-in-single-young-women-with-polycystic-ovary-syndrome
#19
Emaduldin Seyam, Saad Al Gelany, Ahmed Abd Al Ghaney, Marwa Abd Allah Mohamed, Ayman Moheb Youseff, Emad Moussa Ibrahim, Eissa M Khalifa, Enas Hefzy
OBJECTIVE: The aim of the current work was to investigate the effects of prolonged use of Statins on the clinical and biochemical abnormalities and ovulation dysfunction in young single women with polycystic ovary syndrome (PCOS). PATIENTS AND METHODS: It was a randomized, double-blind, placebo-controlled study. Where 200 single young women with PCOS were randomized into either 100 (n = 100) women using Simvastatin 20 mg daily considered as group A (study group), or 100 (n = 100) women using placebo and considered as group B (control group), for six months treatment period...
December 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29241757/cutaneous-manifestations-of-obesity-and-themetabolic-syndrome
#20
Tuğba Kevser Uzuncakmak, Necmettin Akdeniz, Ayse Serap Karadag
The cutaneous manifestations of obesity and the associated metabolic syndrome (MetS) may present with a wide variety of cutaneous findings, including acanthosis nigricans, acrochordon, cellulitis, psoriasis, hidradenitis suppurativa, acne, and hirsutism. Being aware of such clinical signs and the underlying systemic disorders may facilitate earlier diagnoses, thereby permitting earlier of therapy initiation and prevention of long-term sequelae. In this process, dermatologists are key figures in the early detection of MetS and its clinical manifestations...
January 2018: Clinics in Dermatology
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