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https://www.readbyqxmd.com/read/29915727/comparing-the-frequency-of-polycystic-ovary-syndrome-in-women-with-and-without-epilepsy
#1
Leila Amini, Marjan Hematian, Ali Montazeri, Korosh Gharegozli
Introduction: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders; the impact of epilepsy and antiepileptic drugs influences the function of hypothalamic-pituitary-gonadal axis and dysfunction of the endocrine system and reproductive hormones in women with epilepsy. This study was carried out with an aim of determining and comparing the frequency and intensity of the complications of the hirsutism in women with and without epilepsy in Tehran in 2016-2017. Materials and Methods: This is a cross-sectional-comparative study which was carried out on 338 women of 18-35-year-old women with and without epilepsy who were selected by continuous sampling method...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29914248/anxiety-and-depression-states-of-adolescents-with-polycystic-ovary-syndrome
#2
Hamdi Cihan Emeksiz, Aysun Bideci, Burçin Nalbantoğlu, Ayşin Nalbantoğlu, Cem Çelik, Yasemin Yulaf, Mahmut Orhun Çamurdan, Peyami Cinaz
Background/aim: Various studies have shown that adult patients with polycystic ovary syndrome (PCOS) have higher levels of anxiety and depression compared to their normal counterparts. However, it is still unclear whether these mood disorders already exist in adolescents affected by PCOS. The aim of the present study is to assess differences in anxiety and depression levels between adolescents with PCOS and age- and body mass index (BMI)-matched controls and to determine the possible factor(s) impacting these psychological parameters in adolescents with PCOS...
June 14, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29909741/long-term-follow-up-of-a-female-patient-with-non-classical-11%C3%AE-hydroxylase-deficiency-and-two-novel-mutations-in-cyp11b1
#3
Sabina Zacharieva, Ralitsa Robeva, Silvia Andonova, Radoslava Vazharova, Lubomir Balabanski, Maya Atanasoska, Draga Toncheva, Atanaska Elenkova, Alexey Savov
11β-Hydroxylase deficiency is the second most common enzyme disorder after 21-hydroxylase deficiency causing congenital adrenal hyperplasia (CAH11β ). In females, the clinical phenotype of CAH11β classic forms is associated with ambiguous genitalia, virilization and hypertension, while most common complaints in milder non-classic forms include hirsutism, acne, menstrual disturbances, and infertility. Herein, we present clinical and genetic characteristics of an adult woman with 11β-hydroxylase deficiency, hypertension and infertility; she has been followed up from her first pregnancy to her early menopause...
June 17, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29892487/twin-penile-skin-flap-is-it-the-answer-for-repair-of-long-anterior-urethral-strictures
#4
Diaaeldin Mostafa, Hisham Elshawaf, M Kotb, Abdelwahab Elkassaby
Objective: To present our twin ventral penile skin flap technique for the management of complex long anterior urethral strictures not caused by lichen sclerosis (LS), with evaluation of surgical outcome and complications. Patients and methods: We retrospectively reviewed patients diagnosed with long complex anterior urethral strictures who were all referred to Ain Shams University hospital and operated on by three reconstructive surgeons. The surgical procedure was carried out as follows: exposure of the urethra through a ventral longitudinal penile skin incision and another perineal incision; two ventral longitudinal dartos-based penile skin flaps are used for urethral augmentation as onlay flaps...
June 2018: Arab Journal of Urology
https://www.readbyqxmd.com/read/29885664/zumba-induced-takotsubo-cardiomyopathy-a-case-report
#5
Sana Chams, Skye El Sayegh, Mulham Hamdon, Sarwan Kumar, Zain Kulairi
BACKGROUND: Takotsubo cardiomyopathy or stress cardiomyopathy is characterized by transient left ventricular apical ballooning in the absence of coronary occlusion. The underlying pathophysiological mechanism is still unclear but possible causes have been proposed mainly catecholamine cardiotoxicity, followed by metabolic disturbance, coronary microvascular impairment, and multivessel epicardial coronary artery vasospasm. Takotsubo cardiomyopathy accounts for 1-2% of patients presenting with acute coronary syndrome with the majority of patients diagnosed with Takotsubo cardiomyopathy being women > 55 years of age...
June 10, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29880172/elevated-papp-a-levels-in-lean-patients-with-polycystic-ovary-syndrome
#6
Merve Öztürk, Mesut Öktem, S Özlem Altinkaya, Emel Özalp Öktem, Şehri Elbeg, Ahmet Erdem, Mehmet Erdem
OBJECTIVES: This study aimed to evaluate the serum concentrations of PAPP-A (pregnancy associated placental protein-A), a biomarker which is associated with cardiovascular disease, in patients with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: A total of 62 women with PCOS, and 68 age and body mass index (BMI) matched controls were eligible for the study. Hirsutism scores, hormonal and metabolic profile as well as PAPP-A levels were assessed in each subject...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29878857/long-term-response-of-hirsutism-and-other-hyperandrogenic-symptoms-to-combination-therapy-in-polycystic-ovary-syndrome
#7
Uche Ezeh, Andy Huang, Melanie Landay, Ricardo Azziz
BACKGROUND: Polycystic ovary syndrome (PCOS) affects 5%-15% of women and is the most common cause of hirsutism. Data on the time-course of improvement to suppressive therapy and predictors of that response in PCOS are lacking. The objectives of our study are to determine the long-term response and identify predictors of response in PCOS women treated with suppressive therapy, including spironolactone (SPL) + oral contraceptives (OCs). MATERIALS AND METHODS: Retrospective cross-sectional analysis of 200 women with PCOS (1990 NIH criteria) treated with suppressive therapy in general, and a subgroup of 138 subjects treated with OCP+SPL who had been prospectively included in a biorepository...
June 7, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29875533/a-cross-sectional-study-on-the-proportion-of-anxiety-and-depression-and-determinants-of-quality-of-life-in-polycystic-ovarian-disease
#8
Aparna Prathap, T P Subhalakshmi, P Joseph Varghese
Background: The polycystic ovary syndrome is a disorder characterized by hyperandrogenism, ovulatory dysfunction, and polycystic ovarian morphologic features. Earlier studies have shown that depression was significantly increased in the polycystic ovarian disease (PCOD) group and also that PCOD women had marked reduction in quality of life, impaired emotional well-being, and reduced sexual satisfaction. This study was undertaken with the objectives of studying the proportion of anxiety and depression and assessing the quality of life and its correlates in women with PCOD...
May 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29875531/anxiety-depression-and-quality-of-life-in-women-with-polycystic-ovarian-syndrome
#9
Aditi P Chaudhari, Kaustubh Mazumdar, Pooja Deepak Mehta
Background: Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. Symptoms include amenorrhea, hirsutism, infertility, obesity, acne vulgaris, and androgenic alopecia. PCOS is a stigmatizing condition that affects a woman's identity, mental health and quality of life (QOL). This aspect has not received adequate attention in India. Aims and Objectives: (1) To study the prevalence of anxiety and depression among women suffering from PCOS (2) To determine if symptoms of PCOS were associated with psychiatric morbidity, and (3) To determine the impact of psychiatric morbidity on the QOL...
May 2018: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29860059/influence-of-tumour-suppressor-gene-tp53-brca1-and-brca2-polymorphisms-on-polycystic-ovary-syndrome-in-south-indian-women
#10
Swapna Siddamalla, Tumu Venkat Reddy, Suresh Govatati, Praveen Guruvaiah, Mamata Deenadayal, Sisinthy Shivaji, Manjula Bhanoori
OBJECTIVE: Polycystic Ovary Syndrome (PCOS) is a heterogeneous multifactorial endocrine metabolic disorder. In addition to hyperandrogenism, acne, hirsutism, obesity, oligoanovulation and infertility, insulin resistance is also a common feature in women of PCOS. Tumor suppressor genes (TSGs) perform essential function in the maintenance of genomic stability and regulatory pathways influencing the activity of several replication and transcription factors. The main aim of this study was to investigate the association of Single Nucleotide Polymorphisms of TP53, BRCA1and BRCA2 genes with the susceptibility to PCOS in South Indian women...
May 24, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29851127/simplified-4-item-criteria-for-polycystic-ovary-syndrome-a-bridge-too-far
#11
Inthrani R Indran, Zhongwei Huang, Lay Wai Khin, Jerry K Y Chan, Veronique Viardot-Foucault, E L Yong
OBJECTIVES: Though the Rotterdam 2003 polycystic ovarian syndrome (PCOS) diagnostic criteria is widely used, the need to consider multiple variables makes it unwieldy in clinical practice. We propose a simplified PCOS criteria wherein diagnosis is made if two of the following three items were present: a) oligomenorrhoea b) anti-mullerian hormone (AMH) above threshold and/or c) hyperandrogenism defined as either testosterone above threshold and/or the presence of hirsutism. DESIGN SETTING, AND PARTICIPANTS: This prospective cross-sectional study consists of healthy women (n=157) recruited at an annual hospital health screen for staff and volunteers from the university community, and a patient cohort (n=174) comprising women referred for suspected PCOS...
May 30, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29791179/-virilization-as-demonstration-of-hypertestosteronism-by-ovarian-tumor-case-report
#12
Michal Mokáň, František Nehaj, Juraj Sokol, Peter Vaňuga, Marián Mokáň
Hypertestosteronism as part of hyperandrogenic states in women is generally defined as abundance of male hormones (in this case abundance of testosterone). Spectrum of clinical symptoms include menstrual disorders, amenorrhoea, different range of hirsutism and virilization. Statistically, most androgen secreting tumors are ovarian aetiology (testosterone secreting tumors located in suprarenal gland are very rare). This rare tumor may produce excess amounts of testosterone, as well as its precursor androstenedione...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29763897/does-the-pituitary-gland-volume-change-in-polycystic-ovary-syndrome
#13
Sezen Bozkurt Koseoglu, Funda Dinc Elibol
AIMS: Polycystic ovary syndrome (PCOS) is the commonest cause of menstrual irregularity and hirsutism during reproductive age. We hypothesized in the alterations in the pituitary gland in PCOS. METHODS: We measured the volume of the pituitary gland in 39 PCOS patients and 42 age-matched healthy controls using 0.35 mm thick T1-weighted sagittal cranial images. Serum levels of estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured on days 3-5 of the menstrual cycle of the participants...
May 15, 2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29755223/study-to-evaluate-the-changes-in-polycystic-ovarian-morphology-after-naturopathic-and-yogic-interventions
#14
M Ezhil Ratnakumari, N Manavalan, D Sathyanath, Y Rosy Ayda, K Reka
Background: Polycystic ovarian syndrome (PCOS) is one of the commonest endocrine disorders in women, with a prevalence ranging from 2.2% to 26% in India. Patients with PCOS face challenges including irregular menstrual cycles, hirsutism, acne, acanthosis nigricans, obesity and infertility. 9.13% of South Indian adolescent girls are estimated to suffer from PCOS. The efficacy of Yoga & Naturopathy (Y&N) in the management of polycystic ovarian syndrome requires to be investigated...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29734859/evaluation-of-serum-anti-nuclear-antibody-among-women-with-pcos-a-hospital-based-single-center-cross-sectional-study
#15
Aafia Rashid, Javaid Ahmad Bhat, Mohd Ashraf Ganie, Imtiyaz Ahmad Wani, Moomin Hussain Bhat, Zaffar Amin Shah, Shariq R Masoodi, R K Marwaha
Polycystic ovary syndrome (PCOS), a major endocrinopathy is associated with barrage of metabolic aberrations. Reports in literature on association of PCOS and autoimmunity are conflicting. We aim to evaluate serum levels of anti-nuclear antibody (ANA) among Indian women with PCOS. In this hospital-based single center cross-sectional study, women qualifying a diagnosis of PCOS by Rotterdam criteria 2003 were recruited. Eighty-nine eligible women who consented were enrolled. All these women along with 87 age-matched, healthy controls underwent, clinical (menstrual history, anthropometry, hirsutism scoring), biochemical, hormonal assessment and serum ANA estimation...
May 7, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29725277/use-of-oral-contraceptives-for-management-of-acne-vulgaris-and-hirsutism-in-women-of-reproductive-and-late-reproductive-age
#16
Radosław Słopień, Ewa Milewska, Piotr Rynio, Błażej Męczekalski
Hormonal contraception in both reproductive and late reproductive age, as well as contraceptive action, is used also for other indications like dysmenorrhoea, menstrual disorders, endometriosis, acne vulgaris, and hirsutism. Acne vulgaris and hirsutism are important signs related to hyperandrogenaemia and present a serious medical problem for the patients and a challenge for medical doctors in terms of effective treatment. The application of hormonal contraception to treat acne vulgaris and hirsutism requires knowledge of the mechanism of antiandrogenic actions and the possible contraindications and complications...
March 2018: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/29704382/establishing-the-cut-off-values-of-androgen-markers-in-the-assessment-of-polycystic-ovarian-syndrome
#17
R N D Nadaraja, P Sthaneshwar, N Razali
INTRODUCTION: Hyperandrogenism remains as one of the key features in Polycystic Ovarian Syndrome (PCOS) and can be assessed clinically or determined by biochemical assays. Hirsutism is the most common clinical manifestation of hyperandrogenism. The clinical assessment is subjected to wide variability due to poor interobserver agreement and multiple population factors such as ethnic variation, cosmetic procedures and genetic trait. The difficulty in resolving the androgen excess biochemically is due to a lack of consensus as to which serum androgen should be measured for the diagnosis of PCOS...
April 2018: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29685454/pathophysiology-of-glucocorticoid-signaling
#18
Géraldine Vitellius, Séverine Trabado, Jérôme Bouligand, Brigitte Delemer, Marc Lombès
Glucocorticoids (GC), such as cortisol or dexamethasone, control various physiological functions, notably those involved in development, metabolism, inflammatory processes and stress, and exert most of their effects upon binding to the glucocorticoid receptor (GR, encoded by NR3C1 gene). GC signaling follows several consecutive steps leading to target gene transactivation, including ligand binding, nuclear translocation of ligand-activated GR complexes, DNA binding, coactivator interaction and recruitment of functional transcriptional machinery...
June 2018: Annales D'endocrinologie
https://www.readbyqxmd.com/read/29670770/genetic-variants-associated-with-hyperandrogenemia-in-pcos-pathophysiology
#19
REVIEW
Roshan Dadachanji, Nuzhat Shaikh, Srabani Mukherjee
Polycystic ovary syndrome is a multifactorial endocrine disorder whose pathophysiology baffles many researchers till today. This syndrome is typically characterized by anovulatory cycles and infertility, altered gonadotropin levels, obesity, and bulky multifollicular ovaries on ultrasound. Hyperandrogenism and insulin resistance are hallmark features of its complex pathophysiology. Hyperandrogenemia is a salient feature of PCOS and a major contributor to cosmetic anomalies including hirsutism, acne, and male pattern alopecia in affected women...
2018: Genetics Research International
https://www.readbyqxmd.com/read/29669566/apa-i-polymorphism-in-vdr-gene-is-related-to-metabolic-syndrome-in-polycystic-ovary-syndrome-a-cross-sectional-study
#20
Betânia Rodrigues Santos, Sheila Bunecker Lecke, Poli Mara Spritzer
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine disorder determined by polygenic traits as well as environmental factors. Lower vitamin D levels have been detected in PCOS women and related to hormone and metabolic disturbances. Vitamin D acts in tissues through the vitamin D receptor (VDR). VDR gene variants have been associated with worse metabolic profile in the general population. We investigated the genotype and haplotype distribution of the Bsm-I (rs1544410), Apa-I (rs7975232), and Taq-I (rs731236) VDR gene polymorphisms in PCOS and non-hirsute women from southern Brazil...
April 18, 2018: Reproductive Biology and Endocrinology: RB&E
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