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Prediabetes and weight loss

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https://www.readbyqxmd.com/read/27890521/financial-incentives-for-diabetes-prevention-in-a-medicaid-population-study-design-and-baseline-characteristics
#1
Jay Desai, Gretchen Taylor, Gabriela Vazquez-Benitez, Sara Vine, Julie Anderson, Joyce E Garrett, Todd Gilmer, Houa Vue-Her, Jeff Schiff, Sarah Rinn, Katelyn Engel, Amy Michael, Patrick J O'Connor
BACKGROUND: Medicaid beneficiaries at high risk for diabetes can benefit from the Diabetes Prevention Program (DPP) lifestyle intervention. The We Can Prevent Diabetes (WCPD) trial examined whether financial incentives are more effective than no financial incentives in sustaining participation in the DPP and increasing weight loss. Here we describe the study design and baseline characteristics. METHODS: The WCPD was a 3-arm group-randomized controlled trial. Medicaid beneficiaries were aged 18 to 74 years, had prediabetes or gestational diabetes, and were overweight or obese...
November 23, 2016: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/27828773/implementation-of-the-ymca-diabetes-prevention-program-throughout-an-integrated-health-system-a-translational-study
#2
Ron Adams, Christopher J Hebert, Linda Mcvey, Roger Williams
CONTEXT: HealthSpan Physicians (HSP), an integrated medical system in Northeast Ohio, partnered with the Young Men's Christian Association (YMCA) of Greater Cleveland to implement a referral system for the evidence-based Diabetes Prevention Program (DPP) throughout HSP. The YMCA of USA employs a cost-effective, customized version of the original DPP in which coaches take the place of in-house clinical staff. Efficacy of the YMCA DPP was shown earlier in the DEPLOY Study. OBJECTIVE: To improve outcomes of metrics used in the DEPLOY Study...
2016: Permanente Journal
https://www.readbyqxmd.com/read/27828003/announcement-national-diabetes-month-november-2016
#3
(no author information available yet)
November is National Diabetes Month. In the United States, 29 million persons have diabetes and 86 million adults have prediabetes, putting them at risk for developing type 2 diabetes, heart disease, and stroke (1). Approximately 28% of those with diabetes are undiagnosed (1), and 89% of those with prediabetes do not know they have it (2). Type 2 diabetes, which accounts for 90%-95% of all cases of diagnosed diabetes in the United States, can be prevented through lifestyle changes, such as weight loss, healthy eating, and increased physical activity (1,3)...
November 4, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27804269/early-weight-loss-with-liraglutide-3-0-mg-predicts-1-year-weight-loss-and-is-associated-with-improvements-in-clinical-markers
#4
Ken Fujioka, Patrick M O'Neil, Melanie Davies, Frank Greenway, David C W Lau, Birgitte Claudius, Trine Vang Skjøth, Christine Bjørn Jensen, John P H Wilding
OBJECTIVE: To identify an early response criterion for predicting ≥5% weight loss with liraglutide 3.0 mg at week 56 and to compare efficacy outcomes in early responders (ERs) and early nonresponders (ENRs). METHODS: Using pooled data from the SCALE Obesity and Prediabetes and SCALE Diabetes trials, weight loss of ≥4% at 16 weeks best predicted ≥5% weight loss after 56 weeks. Weight loss and changes in cardiometabolic risk factors and health-related quality of life were evaluated in ERs (≥4% weight loss at week 16) and ENRs (<4% weight loss at week 16) completing 56 weeks' treatment...
November 2016: Obesity
https://www.readbyqxmd.com/read/27796775/the-healthy-living-partnerships-to-prevent-diabetes-and-the-diabetes-prevention-program-a-comparison-of-year-1-and-2-intervention-results
#5
Mara Z Vitolins, Scott P Isom, Caroline S Blackwell, Donna Kernodle, Joyce M Sydell, Carolyn F Pedley, Jeffrey A Katula, L Douglas Case, David C Goff
A number of research studies have attempted to translate the behavioral lifestyle intervention delivered in the Diabetes Prevention Program (DPP). To compare the active interventions of two trials, Diabetes Prevention Program DPP and Healthy Living Partnerships to Prevent Diabetes (HELP PD), after 1 and 2 years of intervention. DPP included 3234 adults with prediabetes randomized to intensive lifestyle intervention, metformin, troglitazone, or placebo. The lifestyle intervention, professionally delivered to individuals in a clinical setting, focused on diet and increased physical activity...
October 28, 2016: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/27706216/clinical-and-economic-impact-of-a-digital-remotely-delivered-intensive-behavioral-counseling-program-on-medicare-beneficiaries-at-risk-for-diabetes-and-cardiovascular-disease
#6
Fang Chen, Wenqing Su, Shawn H Becker, Mike Payne, Cynthia M Castro Sweet, Anne L Peters, Timothy M Dall
BACKGROUND: Type 2 diabetes and cardiovascular disease impose substantial clinical and economic burdens for seniors (age 65 and above) and the Medicare program. Intensive Behavioral Counseling (IBC) interventions like the National Diabetes Prevention Program (NDPP), have demonstrated effectiveness in reducing excess body weight and lowering or delaying morbidity onset. This paper estimated the potential health implications and medical savings of a digital version of IBC modeled after the NDPP...
2016: PloS One
https://www.readbyqxmd.com/read/27659698/lorcaserin-treatment-allows-for-decreased-number-needed-to-treat-for-weight-and-glycemic-parameters-in-week-12-responders-with-%C3%A2-5-weight-loss
#7
Yehuda Handelsman, Randi Fain, Zhixiao Wang, Xuan Li, Ken Fujioka, William Shanahan
OBJECTIVES: Lorcaserin is a serotonin 2C receptor agonist approved for chronic weight management. This analysis explores the number of patients needed to be treated (NNT) with lorcaserin for one more patient to achieve weight loss and glycemic goals. METHODS: This is a post hoc analysis of three Phase 3 studies in adults with and without type 2 diabetes mellitus (T2DM) treated with lorcaserin 10 mg BID or placebo. NNT is reported for patients achieving ≥5% or ≥10% weight loss, achievement of either HbA1c <5...
September 23, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27651911/weight-loss-efficacy-of-a-novel-mobile-diabetes-prevention-program-delivery-platform-with-human-coaching
#8
Andreas Michaelides, Christine Raby, Meghan Wood, Kit Farr, Tatiana Toro-Ramos
OBJECTIVE: To evaluate the weight loss efficacy of a novel mobile platform delivering the Diabetes Prevention Program. RESEARCH DESIGN AND METHODS: 43 overweight or obese adult participants with a diagnosis of prediabetes signed-up to receive a 24-week virtual Diabetes Prevention Program with human coaching, through a mobile platform. Weight loss and engagement were the main outcomes, evaluated by repeated measures analysis of variance, backward regression, and mediation regression...
2016: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/27493797/community-engaged-lifestyle-modification-research-engaging-diabetic-and-prediabetic-african-american-women-in-community-based-interventions
#9
Starla Hairston Blanks, Henrie Treadwell, Anya Bazzell, Whitney Graves, Olivia Osaji, Juanita Dean, James T McLawhorn, Jareese Lee Stroud
Purpose. The I Am Woman (IAW) Program is a community-based, culturally responsive, and gender-specific nutrition, obesity, and diabetes educational prevention program designed for African American women (AAW). Chronic nutrition-related health conditions such as excess body weight, diabetes mellitus, cardiovascular disease, and some forms of cancer are common among many African American women. Methods. IAW engaged AAW at risk for such deleterious health conditions by developing a health education intervention that aimed to support weight loss and management, improve knowledge about healthy lifestyle behavioral choices, and facilitate increased access to comprehensive healthcare...
2016: Journal of Obesity
https://www.readbyqxmd.com/read/27459705/cardiometabolic-risk-factor-changes-observed-in-diabetes-prevention-programs-in-us-settings-a-systematic-review-and-meta-analysis
#10
Uma Mudaliar, Azadeh Zabetian, Michael Goodman, Justin B Echouffo-Tcheugui, Ann L Albright, Edward W Gregg, Mohammed K Ali
BACKGROUND: The Diabetes Prevention Program (DPP) study showed that weight loss in high-risk adults lowered diabetes incidence and cardiovascular disease risk. No prior analyses have aggregated weight and cardiometabolic risk factor changes observed in studies implementing DPP interventions in nonresearch settings in the United States. METHODS AND FINDINGS: In this systematic review and meta-analysis, we pooled data from studies in the United States implementing DPP lifestyle modification programs (focused on modest [5%-7%] weight loss through ≥150 min of moderate physical activity per week and restriction of fat intake) in clinical, community, and online settings...
July 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27459502/mothers-after-gestational-diabetes-in-australia-magda-a-randomised-controlled-trial-of-a-postnatal-diabetes-prevention-program
#11
Sharleen L O'Reilly, James A Dunbar, Vincent Versace, Edward Janus, James D Best, Rob Carter, Jeremy J N Oats, Timothy Skinner, Michael Ackland, Paddy A Phillips, Peter R Ebeling, John Reynolds, Sophy T F Shih, Virginia Hagger, Michael Coates, Carol Wildey
BACKGROUND: Gestational diabetes mellitus (GDM) is an increasingly prevalent risk factor for type 2 diabetes. We evaluated the effectiveness of a group-based lifestyle modification program in mothers with prior GDM within their first postnatal year. METHODS AND FINDINGS: In this study, 573 women were randomised to either the intervention (n = 284) or usual care (n = 289). At baseline, 10% had impaired glucose tolerance and 2% impaired fasting glucose. The diabetes prevention intervention comprised one individual session, five group sessions, and two telephone sessions...
July 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27450685/sleep-duration-and-diabetes-risk-in-american-indian-and-alaska-native-participants-of-a-lifestyle-intervention-project
#12
Daniel S Nuyujukian, Janette Beals, Haixiao Huang, Ann Johnson, Ann Bullock, Spero M Manson, Luohua Jiang
STUDY OBJECTIVES: We examine the association between self-reported sleep duration and diabetes incidence in a national sample of American Indians/ Alaska Natives (AI/ANs) with prediabetes. METHODS: Data were derived from the Special Diabetes Program for Indians Diabetes Prevention demonstration project. This longitudinal analysis included 1,899 participants with prediabetes recruited between January 1, 2006 and July 31, 2009 who reported sleep duration and completed all 16 classes of the lifestyle intervention consisting of diet, exercise, and behavior modification sessions to promote weight loss...
November 1, 2016: Sleep
https://www.readbyqxmd.com/read/27421729/effects-of-exercise-training-alone-vs-a-combined-exercise-and-nutritional-lifestyle-intervention-on-glucose-homeostasis-in-prediabetic-individuals-a-randomised-controlled-trial
#13
Cris A Slentz, Lori A Bateman, Leslie H Willis, Esther O Granville, Lucy W Piner, Gregory P Samsa, Tracy L Setji, Michael J Muehlbauer, Kim M Huffman, Connie W Bales, William E Kraus
AIMS/HYPOTHESIS: Although the Diabetes Prevention Program (DPP) established lifestyle changes (diet, exercise and weight loss) as the 'gold standard' preventive therapy for diabetes, the relative contribution of exercise alone to the overall utility of the combined diet and exercise effect of DPP is unknown; furthermore, the optimal intensity of exercise for preventing progression to diabetes remains very controversial. To establish clinical efficacy, we undertook a study (2009 to 2013) to determine: how much of the effect on measures of glucose homeostasis of a 6 month programme modelled after the first 6 months of the DPP is due to exercise alone; whether moderate- or vigorous-intensity exercise is better for improving glucose homeostasis; and to what extent amount of exercise is a contributor to improving glucose control...
October 2016: Diabetologia
https://www.readbyqxmd.com/read/27413670/a-pilot-randomized-trial-of-technology-assisted-goal-setting-to-improve-physical-activity-among-primary-care-patients-with-prediabetes
#14
Devin M Mann, Joseph Palmisano, Jenny J Lin
Lifestyle behavior changes can prevent progression of prediabetes to diabetes but providers often are not able to effectively counsel about preventive lifestyle changes. We developed and pilot tested the Avoiding Diabetes Thru Action Plan Targeting (ADAPT) program to enhance primary care providers' counseling about behavior change for patients with prediabetes. Primary care providers in two urban academic practices and their patients with prediabetes were recruited to participate in the ADAPT study, an unblinded randomized pragmatic trial to test the effectiveness of the ADAPT program, including a streamlined electronic medical record-based goal setting tool...
December 2016: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27406163/impact-of-weight-gain-on-the-evolution-and-regression-of-prediabetes-a-quantitative-analysis
#15
Y Nakasone, T Miyakoshi, Y Sato, K Yamauchi, R Hashikura, M Takayama, K Hirabayashi, H Koike, T Aizawa
BACKGROUND/OBJECTIVES: The quantitative impact of weight gain on prediabetic glucose dysregulation remains unknown; only one study quantitated the impact of weight loss. We quantified the impact of weight gain on the evolution and regression of prediabetes (PDM). SUBJECTS/METHODS: In 4234 subjects without diabetes, using logistic regression analysis with a 4.8-year follow-up period, we analyzed the relationship between (1) δBMI (BMIfollow-up-basal) and the progression from normal glucose regulation (NGR) to PDM or diabetes, and (2) δBMI and the regression from PDM to NGR...
July 13, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27267055/serum-microrna-196-and-microrna-200-in-pancreatic-ductal-adenocarcinoma-of-patients-with-diabetes-mellitus
#16
Pavel Škrha, Aleš Hořínek, Eva Pazourková, Jan Hajer, Přemysl Frič, Jan Škrha, Michal Anděl
BACKGROUND/OBJECTIVES: Our aim was to compare expressions of 6 microRNAs (miRNAs) in patients with pancreatic ductal adenocarcinoma (PAC) and non-cancer patients, moreover according to the presence or absence of diabetes mellitus. METHODS: Expressions of miRNA-192, -196, -200, -21, -30 and -423 were measured in 77 patients with PAC and 64 non-cancer patients (34 patients with type 2 DM and 30 control persons). 60 patients with PAC (78%) had DM or prediabetes and it was of new-onset (less than 2 years before the cancer diagnosis) in 44 out of them...
September 2016: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/27116910/evaluation-of-lorcaserin-on-progression-of-prediabetes-to-type-2-diabetes-and-reversion-to-euglycemia
#17
Richard Nesto, Randi Fain, Yuhan Li, William Shanahan
OBJECTIVES: Lorcaserin is a selective 5-HT2C (5-hydroxytryptamine 2C) receptor agonist indicated for weight management. Here, we assess the impact of lorcaserin on progression from prediabetes to type 2 diabetes (T2D) and on reversion from prediabetes to euglycemia. METHODS: This is a post hoc analysis of pooled data from two Phase 3 studies, BLOOM and BLOSSOM (N = 6136), evaluating the impact of lorcaserin on weight and glycemic parameters over 52 weeks in the subpopulation of obese/overweight subjects with prediabetes, alternately defined by fasting plasma glucose (FPG) 100-125 mg/dl or glycated hemoglobin (HbA1c) 5...
May 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27079343/diabetes-nutrition-therapy-effectiveness-macronutrients-eating-patterns-and-weight-management
#18
REVIEW
Marion J Franz
BACKGROUND: Diabetes nutrition therapy provided for individuals with diabetes must be based on research documenting effectiveness. The roles of differing macronutrient percentages, eating patterns and weight loss interventions are controversial. METHODS: A review of research related to these topics is summarized. RESULTS: Clinical trials as well as systematic reviews and Cochrane reviews report an approximately 1-2% lowering of hemoglobin A1c as well as other beneficial outcomes from nutrition therapy interventions, depending on the type and duration of diabetes and level of glycemic control...
April 2016: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/27005405/effect-of-liraglutide-3-0%C3%A2-mg-in-individuals-with-obesity-and-moderate-or-severe-obstructive-sleep-apnea-the-scale-sleep-apnea-randomized-clinical-trial
#19
A Blackman, G D Foster, G Zammit, R Rosenberg, L Aronne, T Wadden, B Claudius, C B Jensen, E Mignot
BACKGROUND: Obesity is strongly associated with prevalence of obstructive sleep apnea (OSA), and weight loss has been shown to reduce disease severity. OBJECTIVE: To investigate whether liraglutide 3.0 mg reduces OSA severity compared with placebo using the primary end point of change in apnea-hypopnea index (AHI) after 32 weeks. Liraglutide's weight loss efficacy was also examined. SUBJECTS/METHODS: In this randomized, double-blind trial, non-diabetic participants with obesity who had moderate (AHI 15-29...
August 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/26983624/management-of-pregnant-women-with-type-2-diabetes-mellitus-and-the-consequences-of-fetal-programming-in-their-offspring
#20
REVIEW
Diane C Berry, Kim Boggess, Quinetta B Johnson
The obesity epidemic has fueled an epidemic of prediabetes and type 2 diabetes mellitus in women of childbearing age. This paper examines the state of the science on preconception and pregnancy management of women with type 2 diabetes to optimize outcomes for the women and their infants. In addition, the consequence of fetal programming as a result of suboptimal maternal glycemic control is discussed. The paper focuses on type 2 diabetes, not type 1 diabetes or gestational diabetes. Management of women with type 2 diabetes includes preconception counseling, preconception weight management and weight loss, proper weight gain during pregnancy, self-monitoring of blood glucose levels, medication, medical nutrition therapy, and exercise...
May 2016: Current Diabetes Reports
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