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Prediabetes and weight loss

Tiffany L Gary-Webb, Elizabeth A Walker, Lindsey Realmuto, Alexandra Kamler, Jennifer Lukin, William Tyson, Olveen Carrasquillo, Linda Weiss
The Diabetes Prevention Program (DPP) landmark randomized trial demonstrated that participants with prediabetes could reduce their risk for type 2 diabetes by 58% if they achieved 5%-7% weight loss through healthy eating and increasing physical activity. The National DPP (NDPP) is a group intervention based on the DPP and has been widely disseminated by the Centers for Disease Control and Prevention (CDC) and many healthcare institutions. While data show that the program is effective in diverse populations, enrollment among men from low-income and minority communities is low...
March 1, 2018: American Journal of Men's Health
Elizabeth A Walker, Linda Weiss, Tiffany L Gary-Webb, Lindsey Realmuto, Alexandra Kamler, Joseph Ravenell, Carlos Tejeda, Jennifer Lukin, Clyde B Schechter
There is a significant evidence base for the Diabetes Prevention Program, a lifestyle intervention to prevent onset of type 2 diabetes among high-risk individuals; however, translation of this intervention for men has been challenging. This report presents outcomes of the pilot study of an adapted 16-week diabetes prevention program entitled " Power Up for Health." The study goal was to better engage men of color with prediabetes from disadvantaged neighborhoods of New York City. It was implemented at five different recreation centers located in predominantly low-income neighborhoods across New York City...
March 1, 2018: American Journal of Men's Health
M Kaye Kramer, Karl K Vanderwood, Vincent C Arena, Rachel G Miller, Rebecca Meehan, Yvonne L Eaglehouse, Gerald Schafer, Elizabeth M Venditti, Andrea M Kriska
Purpose The purpose of this study is to evaluate the feasibility and effectiveness of an adapted Diabetes Prevention Program (DPP) lifestyle program, DPP Group Lifestyle Balance (GLB), delivered in 3 economically diverse senior/community centers. Methods The DPP-GLB was implemented in 3 senior/community centers in Allegheny County, PA. A 6-month delayed control intervention design was used. Participants were randomized to begin the DPP-GLB immediately (immediate) or after a 6-month delay (delayed). Adults (n = 134; mean age = 62...
March 1, 2018: Diabetes Educator
Estelle Everett, Brian Kane, Ashley Yoo, Adrian Dobs, Nestoras Mathioudakis
BACKGROUND: Prediabetes is a high-risk state for the future development of type 2 diabetes, which may be prevented through physical activity (PA), adherence to a healthy diet, and weight loss. Mobile health (mHealth) technology is a practical and cost-effective method of delivering diabetes prevention programs in a real-world setting. Sweetch (Sweetch Health, Ltd) is a fully automated, personalized mHealth platform designed to promote adherence to PA and weight reduction in people with prediabetes...
February 27, 2018: Journal of Medical Internet Research
Dina H Griauzde, Jeffrey T Kullgren, Brad Liestenfeltz, Caroline Richardson, Michele Heisler
Background: Rates of participation in Diabetes Prevention Programs (DPPs) are low. This may be due, in part, to low levels of autonomous motivation (i.e., motivation that arises from internal sources and sustains healthy behaviors over time) to prevent type 2 diabetes (T2DM) among many individuals with prediabetes. Mobile health (mHealth) technologies that incorporate principles from the Self-Determination Theory offer an effective and scalable approach to increase autonomous motivation levels...
2018: Pilot and Feasibility Studies
Nesreen Khidir, Moamena Ahmed El-Matbouly, Davit Sargsyan, Mohammed Al-Kuwari, Moataz Bashah, Michel Gagner
BACKGROUND: Bariatric surgery in adolescents is still under debate. Literature about the long-term impact of laparoscopic sleeve gastrectomy (LSG) on adolescents' obesity and associated morbidities is scarce. It is unknown if LSG shows better long-term results in the adolescent or adult group. AIM: To compare the long-term effectiveness of LSG on obesity and associated comorbidities between adolescents and adults. METHODS: This retrospective study analyzed all patients with morbid obesity who underwent LSG in (2011-2012) and were followed for up to 5 years...
February 11, 2018: Obesity Surgery
Andreas Triantafyllidis, Dimitris Filos, Jomme Claes, Roselien Buys, Véronique Cornelissen, Evangelia Kouidi, Ioanna Chouvarda, Nicos Maglaveras
BACKGROUND: The benefits of regular physical activity for health and quality of life are unarguable. New information, sensing and communication technologies have the potential to play a critical role in computerised decision support and coaching for physical activity. OBJECTIVES: We provide a literature review of recent research in the development of physical activity interventions employing computerised decision support, their feasibility and effectiveness in healthy and diseased individuals, and map out challenges and future research directions...
March 2018: International Journal of Medical Informatics
Seokyung Park, Mi-Hye Woo, Hyun Jung Lim, Suk Chon, Jeong-Taek Woo
We reported the cases in order to evaluate the effects of individualized nutrition interventions for enhancing self-management abilities of prediabetic subjects. We conducted four nutrition interventions for weight control in two subjects with high-risk of type 2 diabetes. The first subject was a 53-year-old housewife, and the second subject was a 46-year-old male office worker. The subjects visited the medical center 4 times during the study period, and the lifestyle interventions were advised by a clinical team comprised physicians, clinical dietitians, and nurses...
January 2018: Clinical Nutrition Research
E Capristo, S Panunzi, A De Gaetano, M Raffaelli, C Guidone, A Iaconelli, L L'Abbate, A L Birkenfeld, R Bellantone, S R Bornstein, G Mingrone
BACKGROUND/OBJECTIVES: As only 1% of clinically eligible subjects choose to undergo surgical treatment for obesity, other options should be investigated. This study aimed to assess the effects of intensive lifestyle modification (ILM) with or without 3-mg liraglutide daily vs. sleeve gastrectomy (SG) on BMI after 1 year. SUBJECTS/METHODS: In this study performed at an Italian university hospital, non-diabetic patients eligible for bariatric surgery were recruited from a weight-loss clinic and had the option to choose from three possible weight-loss programmes up to an allocation of 25 subjects in each arm matched by BMI and age...
December 29, 2017: Diabetes & Metabolism
Marco D DiBonaventura, Henrik Meincke, Agathe Le Lay, Janine Fournier, Erik Bakker, Allison Ehrenreich
Objective: The goal of this study is to investigate obesity and its concomitant effects including the prevalence of comorbidities, its association with patient-reported outcomes and costs, and weight loss strategies in a sample of Mexican adults. Methods: Mexican adults (N=2,511) were recruited from a combination of Internet panels and street intercepts using a random-stratified sampling framework, with strata defined by age and sex, so that they represent the population...
2018: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy
Yoriko Heianza, Dianjianyi Sun, Steven R Smith, George A Bray, Frank M Sacks, Lu Qi
OBJECTIVE: Adiposity and the gut microbiota are both related to the risk of type 2 diabetes. We aimed to comprehensively examine how changes induced by a weight-loss diet intervention in gut microbiota-related metabolites, such as trimethylamine N -oxide (TMAO) and its precursors (choline and l-carnitine), were associated with improvements in adiposity and regional fat deposition. RESEARCH DESIGN AND METHODS: This study included 510 overweight and obese individuals who were randomly assigned one of four diets varying in macronutrient intake...
March 2018: Diabetes Care
Carel le Roux, Vanita Aroda, Joanna Hemmingsson, Ana Paula Cancino, Rune Christensen, Xavier Pi-Sunyer
OBJECTIVE: To investigate whether the efficacy and safety of liraglutide 3.0 mg differed between two subgroups, BMI 27 to <35 and BMI ≥ 35 kg/m², in individuals without and with type 2 diabetes (T2D). METHODS: A post-hoc analysis of two 56-week, randomized, double-blind, placebo-controlled trials (SCALE Obesity and Prediabetes; SCALE Diabetes). Subgroup differences in treatment effects of liraglutide 3.0 mg were evaluated by testing the interaction between treatment group and baseline BMI subgroup...
November 17, 2017: Obesity Facts
Charumathi Baskaran, Nurgun Kandemir
PURPOSE OF REVIEW: Although childhood obesity has leveled off in the last decade, 'severe obesity' continues to be on the rise. Various genetic, environmental and hormonal factors contribute to obesity. This article reviews the most current understanding of obesity's multifactorial origin and recent recommendations for its management in childhood and adolescence. RECENT FINDINGS: Epigenetics plays a key role in transmitting obesity risk to offspring. Single-nucleotide polymorphisms at genetic loci for adipokines and their receptors are associated with obesity...
February 2018: Current Opinion in Endocrinology, Diabetes, and Obesity
J Sonya Haw, Karla I Galaviz, Audrey N Straus, Alysse J Kowalski, Matthew J Magee, Mary Beth Weber, Jingkai Wei, K M Venkat Narayan, Mohammed K Ali
Importance: Diabetes prevention is imperative to slow worldwide growth of diabetes-related morbidity and mortality. Yet the long-term efficacy of prevention strategies remains unknown. Objective: To estimate aggregate long-term effects of different diabetes prevention strategies on diabetes incidence. Data Sources: Systematic searches of MEDLINE, EMBASE, Cochrane Library, and Web of Science databases. The initial search was conducted on January 14, 2014, and was updated on February 20, 2015...
December 1, 2017: JAMA Internal Medicine
R L Kolotkin, B Gabriel Smolarz, H H Meincke, K Fujioka
Previously in the SCALE Obesity and Prediabetes trial, at 1 year, participants with obesity (or overweight with comorbidities) and prediabetes receiving liraglutide 3.0 mg experienced greater improvements in health-related quality of life (HRQoL) than those receiving placebo. The current study extends these findings by examining 3-year changes in HRQoL. HRQoL was assessed using the obesity-specific Impact of Weight on Quality of Life-Lite (IWQOL-Lite) questionnaire, as well as the Short-Form 36 v2 (SF-36) health survey...
October 16, 2017: Clinical Obesity
Carolyn F Pedley, L Douglas Case, Caroline S Blackwell, Jeffrey A Katula, Mara Z Vitolins
AIMS: Large-scale clinical trials and translational studies have demonstrated that weight loss achieved through diet and physical activity reduced the development of diabetes in overweight individuals with prediabetes. These interventions also reduced the occurrence of metabolic syndrome and risk factors linked to other chronic conditions including obesity-driven cancers and cardiovascular disease. The Healthy Living Partnerships to Prevent Diabetes (HELP PD) was a clinical trial in which participants were randomized to receive a community-based lifestyle intervention translated from the Diabetes Prevention Program (DPP) or an enhanced usual care condition...
September 23, 2017: Diabetes & Metabolic Syndrome
Hollie A Raynor, Patricia G Davidson, Heather Burns, Micki D Hall Nadelson, Shelley Mesznik, Virginia Uhley, Lisa Moloney
BACKGROUND: Eleven recommendations, based on systematic reviews, were developed for the Evidence Analysis Library's prevention of type 2 diabetes project. Two recommendations, medical nutrition therapy (MNT) and weight loss, were rated strong. OBJECTIVE: Present the basis of systematic reviews for MNT and weight loss recommendations. METHODS: Literature searches using Medline were conducted to identify studies that met eligibility criteria...
October 2017: Journal of the Academy of Nutrition and Dietetics
S Cameron Sepah, Luohua Jiang, Robert J Ellis, Kelly McDermott, Anne L Peters
OBJECTIVE: Translations of the Diabetes Prevention Program (DPP) have proliferated in recent years, with increasing expansion to digital formats. Although these DPP translations have consistently shown favorable clinical outcomes, long-term data for digital formats are limited. This study's objective was to examine clinical outcomes up to 3 years post-baseline and the relationship between program engagement and clinical outcomes in a digital DPP. RESEARCH DESIGN AND METHODS: In a single-arm, non-randomized trial, 220 patients previously diagnosed with prediabetes were enrolled in the Omada Health Program, a commercially available, 16-week DPP-based weight loss intervention followed by an ongoing weight maintenance intervention...
2017: BMJ Open Diabetes Research & Care
Shira Grock, Jeong-Hee Ku, Julie Kim, Tannaz Moin
PURPOSE OF REVIEW: The high prevalence of prediabetes and success of the diabetes prevention program (DPP) has led to increasing efforts to provide readily accessible, cost-effective DPP interventions to the general public. Technology-assisted DPP interventions are of particular interest since they may be easier to widely distribute and sustain as compared to traditional in-person DPP. The purpose of this article is to provide an overview of currently available technology-assisted DPP interventions...
September 23, 2017: Current Diabetes Reports
Pascal M Mutie, Giuseppe N Giordano, Paul W Franks
The driving force behind the current global type 2 diabetes epidemic is insulin resistance in overweight and obese individuals. Dietary factors, physical inactivity, and sedentary behaviors are the major modifiable risk factors for obesity. Nevertheless, many overweight/obese people do not develop diabetes and lifestyle interventions focused on weight loss and diabetes prevention are often ineffective. Traditionally, chronically elevated blood glucose concentrations have been the hallmark of diabetes; however, many individuals will either remain 'prediabetic' or regress to normoglycemia...
September 22, 2017: BMC Medicine
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