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Prediabetes and weight loss

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https://www.readbyqxmd.com/read/28815383/a-5-year-follow-up-study-of-laparoscopic-sleeve-gastrectomy-among-morbidly-obese-adolescents-does-it-improve-body-image-and-prevent-and-treat-diabetes
#1
Moamena Ahmed El-Matbouly, Nesreen Khidir, Hussien Aly Touny, Walid El Ansari, Mohammed Al-Kuwari, Moataz Bashah
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is widely used, and it is important to examine its physiologic and psychological efficacy among adolescents. We assessed LSG's efficacy for weight loss, its short- and long-term effects on resolving and improving obesity-related comorbidities, and its psychological outcomes among morbidly obese adolescents. METHODS: We retrospectively analyzed the medical records of 91 morbidly obese adolescents in Qatar who underwent LSG (2011-2014), with 1- and 5-year follow-ups...
August 17, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28757449/weight-loss-in-the-prevention-and-treatment-of-diabetes
#2
Linda M Delahanty
The American Diabetes Association nutrition and lifestyle recommendations for prediabetes and type 2 diabetes focus on losing 7% of body weight and increasing physical activity to at least 150minperweek. This emphasis is largely based on results of the Diabetes Prevention Program (DPP) and Look AHEAD (Action for Health in Diabetes) clinical trials. DPP demonstrated that a lifestyle intervention aimed at 7% weight loss and 150min of activity per week reduced diabetes incidence by 58% after 2.8years of follow-up and resulted in sustained improvements in hemoglobinA1c, blood pressure and lipid levels...
July 28, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28730532/survey-of-primary-care-providers-knowledge-of-screening-for-diagnosing-and-managing-prediabetes
#3
Eva Tseng, Raquel C Greer, Paul O'Rourke, Hsin-Chieh Yeh, Maura M McGuire, Jeanne M Clark, Nisa M Maruthur
BACKGROUND: Prediabetes affects 86 million US adults, but primary care providers' (PCPs') knowledge, practices, attitudes and beliefs toward prediabetes are unclear. OBJECTIVE: Assess PCPs' (1) knowledge of risk factors that should prompt prediabetes screening, laboratory criteria for diagnosing prediabetes and guidelines for management of prediabetes; (2) management practices around prediabetes; (3) attitudes and beliefs about prediabetes. DESIGN: Self-administered written survey of PCPs...
July 20, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28727546/a-formative-evaluation-of-a-diabetes-prevention-program-using-the-re-aim-framework-in-a-learning-health-care-system-utah-2013-2015
#4
Kimberly D Brunisholz, Jaewhan Kim, Lucy A Savitz, Mia Hashibe, Lisa H Gren, Sharon Hamilton, Kelly Huynh, Elizabeth A Joy
INTRODUCTION: Evaluation of interventions can help to close the gap between research and practice but seldom takes place during implementation. Using the RE-AIM framework, we conducted a formative evaluation of the first year of the Intermountain Healthcare Diabetes Prevention Program (DPP). METHODS: Adult patients who met the criteria for prediabetes (HbA1c of 5.70%-6.49% or fasting plasma glucose of 100-125 mg/dL) were attributed to a primary care provider from August 1, 2013, through July 31, 2014...
July 20, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28716404/partial-jejunal-diversion-using-an-incisionless-magnetic-anastomosis-system-1-year-interim-results-in-subjects-with-obesity-and-diabetes
#5
Evžen Machytka, Marek Bužga, Pavel Zonca, David B Lautz, Marvin Ryou, Donald C Simonson, Christopher C Thompson
BACKGROUND AND AIMS: The majority of patients with type 2 diabetes mellitus (T2DM) have obesity. Studies show that bariatric surgery is superior to medical treatment for remission of T2DM. Nevertheless, very few patients undergo surgery, and a less-invasive endoscopic alternative is desirable. METHODS: This was a single-arm first-in-human pilot study, designed to evaluate the technical feasibility, safety, and clinical performance of the incisionless magnetic anastomosis system (IMAS) in creation of a partial jejunal diversion (PJD)...
July 14, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/28711517/prevention-of-type-2-diabetes-mellitus-in-polycystic-ovary-syndrome-a-review
#6
REVIEW
Safa Anwar, Nigar Shikalgar
Polycystic ovary syndrome (PCOS) is recognized as one of the most common endocrinopathies in women of reproductive age, associated with metabolic sequelae which includes increased risk factors for impaired glucose tolerance (IGT), type 2 diabetes mellitus (DM2) and cardiovascular disease (CVD). The adverse effects of DM2 affects a woman throughout her lifespan. Health care expenditure of DM2 highlights the need for prevention through appropriate screening, diagnosis and intervention. Lifestyle modification (LSM) programs that include diet and/or physical activity are suggested for patients characterized as prediabetic to delay the onset of adult DM2...
July 8, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28697852/a-multidisciplinary-approach-to-laparoscopic-sleeve-gastrectomy-among-multiethnic-adolescents-in-the-united-states
#7
Joshua D Jaramillo, Elizabeth Snyder, Susan Farrales, Megan Stevens, James K Wall, Stephanie Chao, John Morton, Janey Sa Pratt, Lawrence Hammer, W Elizabeth Shepard, Matias Bruzoni
BACKGROUND: Childhood obesity has become a serious public health problem in our country with a prevalence that is disproportionately higher among minority groups. Laparoscopic sleeve gastrectomy (LSG) is gaining attention as a safe bariatric alternative for severely obese adolescents. STUDY DESIGN: A retrospective study on morbidly obese adolescents that underwent LSG at our institution from 2009 to 2017. Primary outcomes were weight loss as measured by change in BMI and percent excess weight loss (%EWL) at 1 year after surgery, resolution of comorbidities and occurrence of complications...
June 28, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28679551/pretreatment-fasting-plasma-glucose-and-insulin-modify-dietary-weight-loss-success-results-from-3-randomized-clinical-trials
#8
RANDOMIZED CONTROLLED TRIAL
Mads F Hjorth, Christian Ritz, Ellen E Blaak, Wim Hm Saris, Dominique Langin, Sanne Kellebjerg Poulsen, Thomas Meinert Larsen, Thorkild Ia Sørensen, Yishai Zohar, Arne Astrup
Background: Which diet is optimal for weight loss and maintenance remains controversial and implies that no diet fits all patients.Objective: We studied concentrations of fasting plasma glucose (FPG) and fasting insulin (FI) as prognostic markers for successful weight loss and maintenance through diets with different glycemic loads or different fiber and whole-grain content, assessed in 3 randomized trials of overweight participants.Design: After an 8-wk weight loss, participants in the DiOGenes (Diet, Obesity, and Genes) trial consumed ad libitum for 26 wk a diet with either a high or a low glycemic load...
August 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28621654/diabetes-risk-reduction-in-primary-care-evaluation-of-the-ontario-primary-care-diabetes-prevention-program
#9
Michael Hillmer, Guillermo A Sandoval, James A Elliott, Meera Jain, Tiffany Barker, Amy Prisniak, Stoni Astley, Laura Rosella
OBJECTIVES: Lifestyle interventions can reduce type 2 diabetes risk. The Primary Care Diabetes Prevention Program (PCDPP) was implemented by the Government of Ontario to lower diabetes risk. This study first evaluated the program, and second used a validated tool to estimate a potential population impact if the program were implemented more broadly in the province. METHODS: PCDPP was implemented in six primary care settings serving communities with high mortality risk due to chronic diseases...
June 16, 2017: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
https://www.readbyqxmd.com/read/28462892/effect-of-weight-reductions-on-estimated-kidney-function-post-hoc-analysis-of-two-randomized-trials
#10
Bernt Johan von Scholten, Melanie J Davies, Frederik Persson, Tine W Hansen, Sten Madsbad, Lars Endahl, Cecilie H Jepsen, Peter Rossing
AIMS: Weight loss-induced serum creatinine reduction may increase creatinine-based estimated glomerular filtration rate (eGFR) producing incorrect estimates of kidney function. We investigated whether weight changes in the SCALE program with liraglutide 3.0mg were associated with changes in serum creatinine. METHODS: Post hoc analysis of two 56-week, randomized, double-blind trials: SCALE Obesity and Prediabetes (n=3731, without type 2 diabetes [T2D], randomized [2:1] to liraglutide 3...
April 11, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28423969/process-evaluation-of-the-type-2-diabetes-mellitus-pulse-program-randomized-controlled-trial-recruitment-engagement-and-overall-satisfaction
#11
Elroy J Aguiar, Philip J Morgan, Clare E Collins, Ronald C Plotnikoff, Myles D Young, Robin Callister
BACKGROUND: Men are underrepresented in weight loss and type 2 diabetes mellitus (T2DM) prevention studies. PURPOSE: To determine the effectiveness of recruitment, and acceptability of the T2DM Prevention Using LifeStyle Education (PULSE) Program-a gender-targeted, self-administered intervention for men. METHODS: Men (18-65 years, high risk for T2DM) were randomized to intervention ( n = 53) or wait-list control groups ( n = 48). The 6-month PULSE Program intervention focused on weight loss, diet, and exercise for T2DM prevention...
April 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28420105/one-year-results-of-a-synthetic-intervention-model-for-the-primary-prevention-of-t2d-among-elderly-individuals-with-prediabetes-in-rural-china
#12
RANDOMIZED CONTROLLED TRIAL
Zhao Hu, Lulu Qin, Huilan Xu
Objective: The objective of this study was to evaluate the effectiveness of a synthetic intervention model aimed at preventing type 2 diabetes and controlling plasma glucose, body weight and waist circumference in elderly individuals with prediabetes in rural China. Methods: We randomly assigned 434 (180 men and 254 women; mean age, 69 years; mean body mass index, 23.6 kg/m²) with prediabetes to either the intervention group or the control group. Each participant in the intervention group received synthetic intervention for 1 year...
April 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28381495/dietary-reversal-of-neuropathy-in-a-murine-model-of-prediabetes-and-metabolic-syndrome
#13
Lucy M Hinder, Phillipe D O'Brien, John M Hayes, Carey Backus, Andrew P Solway, Catrina Sims-Robinson, Eva L Feldman
Patients with metabolic syndrome, which is defined as obesity, dyslipidemia, hypertension and impaired glucose tolerance (IGT), can develop the same macro- and microvascular complications as patients with type 2 diabetes, including peripheral neuropathy. In type 2 diabetes, glycemic control has little effect on the development and progression of peripheral neuropathy, suggesting that other metabolic syndrome components may contribute to the presence of neuropathy. A parallel phenomenon is observed in patients with prediabetes and metabolic syndrome, where improvement in weight and dyslipidemia more closely correlates with restoration of nerve function than improvement in glycemic status...
June 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28376802/understanding-type-2-diabetes-mellitus-screening-practices-among-primary-care-physicians-a-qualitative-chart-stimulated-recall-study
#14
Dina Hafez, Daniel B Nelson, Evan G Martin, Alicia J Cohen, Rebecca Northway, Jeffrey T Kullgren
BACKGROUND: Early diagnosis and treatment of prediabetes and type 2 diabetes mellitus (T2DM) can prevent future health problems, yet many individuals with these conditions are undiagnosed. This could be due, in part, to primary care physicians' (PCP) screening practices, about which little is known. The objectives of this study were to identify factors that influence PCPs' decisions to screen patients for T2DM and to characterize their interpretation and communication of screening test results to patients...
April 4, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28356073/practical-partnered-research-to-improve-weight-loss-among-overweight-obese-veterans-lessons-from-the-trenches
#15
EDITORIAL
Mona AuYoung, Laura J Damschroder, Linda Kinsinger, Tannaz Moin, Caroline R Richardson
BACKGROUND: Obesity and obesity-related conditions, such as type 2 diabetes, are a major issue for Veteran health. Veterans Health Administration (VA) researchers and health systems leaders have worked separately and together to provide more effective weight management programs for Veterans. Although randomized clinical trials are often considered the gold standard for establishing efficacy of interventions in controlled circumstances, pragmatic clinical trials (PCTs) provide agility for translation...
March 29, 2017: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/28347972/the-effect-of-technology-mediated-diabetes-prevention-interventions-on-weight-a-meta-analysis
#16
Rachel R Bian, Gretchen A Piatt, Ananda Sen, Melissa A Plegue, Mariana L De Michele, Dina Hafez, Christina M Czuhajewski, Lorraine R Buis, Neal Kaufman, Caroline R Richardson
BACKGROUND: Lifestyle interventions targeting weight loss, such as those delivered through the Diabetes Prevention Program, reduce the risk of developing type 2 diabetes. Technology-mediated interventions may be an option to help overcome barriers to program delivery, and to disseminate diabetes prevention programs on a larger scale. OBJECTIVE: We conducted a meta-analysis to evaluate the effect of such technology-mediated interventions on weight loss. METHODS: In this meta-analysis, six databases were searched to identify studies reporting weight change that used technology to mediate diet and exercise interventions, and targeted individuals at high risk for developing type 2 diabetes...
March 27, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28323952/randomized-controlled-trial-of-a-mufa-or-fiber-rich-diet-on-hepatic-fat-in-prediabetes
#17
Isabel Errazuriz, Simmi Dube, Michael Slama, Roberto Visentin, Sunita Nayar, Helen O'Connor, Claudio Cobelli, Swapan Kumar Das, Ananda Basu, Walter Karl Kremers, John Port, Rita Basu
Context: Increased prevalence of type 2 diabetes mellitus and prediabetes worldwide is attributed in part to an unhealthy diet. Objective: To evaluate whether 12 weeks of high monounsaturated fatty acid (MUFA) or fiber-rich weight-maintenance diet lowers hepatic fat and improves glucose tolerance in people with prediabetes. Design: Subjects underwent a [6, 6-2H2]-labeled 75-g oral glucose tolerance test to estimate hepatic insulin sensitivity and liver fat fraction (LFF) using magnetic resonance spectroscopy before and after intervention...
May 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28322645/the-effects-of-a-health-partner-program-on-reducing-cardiovascular-risk-factors
#18
Tingting Liu
Previous lifestyle intervention research targeting prediabetes has primarily focused on weight loss, blood glucose, and lipid abnormalities. Far less is known whether lifestyle interventions lower other biological and physical risk factors for cardiovascular disease in overweight/obese adults with or without prediabetes. The aim of the study was to determine if a health partner program reduced biological and physical cardiovascular risk factors in overweight/obese adults with and without prediabetes at 1 year...
December 1, 2016: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28237635/prevent-dm-comparative-effectiveness-trial-of-lifestyle-intervention-and-metformin
#19
Matthew J O'Brien, Alberly Perez, Adam B Scanlan, Victor A Alos, Robert C Whitaker, Gary D Foster, Ronald T Ackermann, Jody D Ciolino, Carol Homko
INTRODUCTION: Although the Diabetes Prevention Program and other clinical trials demonstrated the efficacy of intensive lifestyle interventions (ILI) and metformin to prevent type 2 diabetes, no studies have tested their comparative effects in pragmatic settings. This study was designed to compare the real-world effectiveness of ILI, metformin, and standard care among Hispanic women (Latinas) with prediabetes. STUDY DESIGN: RCT. SETTING/PARTICIPANTS: Ninety-two Latinas, who had a mean hemoglobin A1c of 5...
June 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28237263/3-years-of-liraglutide-versus-placebo-for-type-2-diabetes-risk-reduction-and-weight-management-in-individuals-with-prediabetes-a-randomised-double-blind-trial
#20
Carel W le Roux, Arne Astrup, Ken Fujioka, Frank Greenway, David C W Lau, Luc Van Gaal, Rafael Violante Ortiz, John P H Wilding, Trine V Skjøth, Linda Shapiro Manning, Xavier Pi-Sunyer
BACKGROUND: Liraglutide 3·0 mg was shown to reduce bodyweight and improve glucose metabolism after the 56-week period of this trial, one of four trials in the SCALE programme. In the 3-year assessment of the SCALE Obesity and Prediabetes trial we aimed to evaluate the proportion of individuals with prediabetes who were diagnosed with type 2 diabetes. METHODS: In this randomised, double-blind, placebo-controlled trial, adults with prediabetes and a body-mass index of at least 30 kg/m(2), or at least 27 kg/m(2) with comorbidities, were randomised 2:1, using a telephone or web-based system, to once-daily subcutaneous liraglutide 3·0 mg or matched placebo, as an adjunct to a reduced-calorie diet and increased physical activity...
April 8, 2017: Lancet
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