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https://www.readbyqxmd.com/read/28226206/exploration-of-the-innate-immune-system-of-styela-clava-zn-2-binding-enhances-the-antimicrobial-activity-of-the-tunicate-peptide-clavanin-a
#1
Samuel A Juliano, Scott Pierce, James A DeMayo, Marcy J Balunas, Alfredo M Angeles-Boza
Tunicates have been used as primitive models for understanding cell mediated and humoral immunity. Clavanin A (ClavA) is a potent antimicrobial peptide produced by the solitary tunicate Styela clava. In this work, we demonstrate that ClavA utilizes Zn(2+) ions to potentiate its antimicrobial activity. A reduced concentration at which the peptide inhibits the growth of bacteria and an increase in the rate of killing is observed in the presence of Zn(2+). Membrane depolarization, β-galactosidase leakage and potassium leakage assays indicate that ClavA is membrane active, forms small pores, but induces cell death by targeting an intracellular component...
February 22, 2017: Biochemistry
https://www.readbyqxmd.com/read/28225311/prognostic-factors-for-survival-of-men1-patients-with-duodenopancreatic-tumors-metastatic-to-the-liver-results-from-the-dmsg-study-group
#2
Elfi B Conemans, Sjoerd Nell, Carolina R C Pieterman, Wouter W de Herder, Olaf M Dekkers, Ad R Hermus, Anouk N van der Horst-Schrivers, Peter H Bisschop, Bas Havekes, Madeleine L Drent, Menno R Vriens, Gerlof D Valk
Objective Duodenopancreatic neuroendocrine tumors (DP-NETs) develop in a majority of patients with Multiple Endocrine Neoplasia Type 1 (MEN1) and are the leading cause of death. Overall survival (OS) and prognostic factors for patients with liver metastases from DP-NETs are not known. Design and Methods Cohort study using the Dutch National MEN1 database, which includes >90% of the Dutch MEN1 population between 1990-2014. OS was assessed with time to event analysis, and prognostic factors were evaluated...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28225064/intravoxel-incoherent-motion-diffusion-weighted-mr-imaging-in-assessing-and-characterizing-solitary-pulmonary-lesions
#3
Qi Wan, Ying-Shi Deng, Jia-Xuan Zhou, Yu-Dong Yu, Ying-Ying Bao, Qiang Lei, Hou-Jin Chen, Ya-Hui Peng, Ying-Jie Mei, Qing-Si Zeng, Xin-Chun Li
This study aimed to investigate the potential of intravoxel incoherent motion (IVIM) diffusion-weighted MR imaging in assessing solitary pulmonary lesions (SPLs). Sixty-two patients with pathologically confirmed SPLs, including 51 and 11 cases of malignant and benign lesions, respectively, were assessed. Diffusion weighted imaging (DWI) with 13 b values was used to derive apparent diffusion coefficient (ADC) and IVIM parameters, including true diffusion coefficient (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f)...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28224562/solitary-choroidal-metastasis-from-gastric-adenocarcinoma-a-case-report
#4
Masanari Shimada, Susumu Amaya, Hiroaki Sugita, Yuichiro Furutani, Yoshinori Munemoto, Takeshi Mitsui, Toshiro Tanahashi, Yuzo Kikuchi
BACKGROUND: Metastatic choroidal carcinomas that originated from the gastrointestinal tract are extremely rare. We report a case of suspected solitary choroidal metastasis from gastric adenocarcinoma. CASE PRESENTATION: The patient was a 60-year-old man who had undergone laparoscopic distal gastrectomy with D1+ lymphadenecetomy for gastric cancer. The clinical stage was T1bN0M0 (TNM classification), but the pathological stage was T4aN0M0 beyond expectation. Adjuvant chemotherapy with oral Tegafur, Gimeracil, Oteracil potassium (TS-1(®)) was initiated...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28223676/-multiple-salvage-radiotherapies-for-metachronous-lymph-node-metastasis-from-gastric-cancer-contributed-to-long-term-management-of-disease
#5
Naoto Hori, Shunsuke Kagawa, Satoru Kikuchi, Shinji Kuroda, Megumi Watanabe, Shuichi Sakamoto, Tetsuya Kagawa, Kazuya Kuwada, Tetsushi Kubota, Hiroyuki Kishimoto, Masahiko Nishizaki, Norihisa Katayama, Toshiyoshi Fujiwara
A 70-year-old man who underwent gastrectomy for Stage III C gastric cancer developed lymph node(LN)metastasis posterior to the pancreatic head 3 years after the radical surgery.He was first treated with radiotherapy(RT)followed by chemotherapy.The irradiated tumor regressed completely.However, the cancer relapsed in a single para-aortic LN and he was treated with RT to the lesion followed by chemotherapy.Although it completely regressed, later, lung metastasis was observed.The lung lesions were well suppressed by switching to docetaxel; however, the cancer relapsed again in a mediastinal LN, and it was not responsive to docetaxel...
February 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28222441/unusual-occurrence-of-multifocal-desmoplastic-infantile-astrocytoma-a-case-report-and-review-of-the-literature
#6
Vinayak Narayan, Amey R Savardekar, Anita Mahadevan, Arimappamagan Arivazhagan, Lingegowda Appaji
Desmoplastic infantile gliomas are rare, benign tumors of the early infancy period. Two histological subtypes - desmoplastic infantile astrocytoma (DIA) and desmoplastic infantile ganglioglioma - have been described. The characteristic features of DIAs are lobar location, glial histology, and excellent prognosis after complete surgical excision. DIAs usually present as solitary, cortical-surfacing, solid-cystic neoplasms; however, atypical, aggressive, and multifocal variants of DIA have been reported in the literature...
February 22, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28220616/exploring-the-relationship-between-activities-and-emotional-experience-using-a-diary-in-a-mental-health-inpatient-setting
#7
Fredrik Folke, Timo Hursti, Jonathan W Kanter, Hans Arinell, Stefan Tungström, Per Söderberg, Lisa Ekselius
Mental health inpatient milieus have repeatedly been found to be associated with passivity, social disengagement, and low levels of interaction with staff. However, little is known about patients' experiences related to different ward activities. In the present study, we aimed to study the reports of activities and associated experiences of patients admitted to acute psychiatric inpatient wards. Disengaged, inactive, and solitary activities were hypothesized to be associated with less reward and more distress than their counterparts...
February 20, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28220189/simple-and-practical-nomograms-for-predicting-the-stone-free-rate-after-shock-wave-lithotripsy-in-patients-with-a-solitary-upper-ureteral-stone
#8
Naoya Niwa, Kazuhiro Matsumoto, Makoto Miyahara, Minami Omura, Hiroaki Kobayashi, Eiji Kikuchi, Akira Miyajima, Kazutoyo Miyata, Mototsugu Oya
PURPOSE: To develop practical nomograms for predicting the stone-free rate after shock wave lithotripsy (SWL) in patients with a solitary stone in the proximal ureter. METHODS: Between July 2006 and June 2015, 319 patients with a proximal ureteral stone who underwent preoperative non-contrast enhanced computed tomography (NCCT) and subsequently received SWL were identified. Patients' age, gender, laterality, stone size, mean and maximum Hounsfield Unit (HU) of the stone, and skin-to-stone distance (SSD) were assessed...
February 20, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28219304/solitary-thoracic-intramedullary-spinal-neurofibroma-microsurgically-extirpated-via-recapping-t-saw-laminoplasty
#9
Mamer Soriano Rosario, Hideki Murakami, Satoshi Kato, Moriyuki Fujii, Noritaka Yonezawa, Hiroyuki Tsuchiya
We report the case of a 40-year-old female presenting with back pain that was complicated by a solitary intramedullary spinal cord mass at the T10-11 levels, confirmed by magnetic resonance imaging and computed tomography myelography. Microsurgical en bloc extirpation of the tumor approached through a recapping T-saw laminoplasty of T10 was done, and histopathology findings revealed a diagnosis of neurofibroma. Solitary spinal neurofibroma is one of the rarest tumors involving the spinal cord and is very adherent for the lack of a well-defined capsule, requiring careful dissection under microscope magnification for successful en bloc resection...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28219174/-solitary-fibrous-tumor-in-the-nasopharynx-a-case-report
#10
W J Zheng, H Zhang
No abstract text is available yet for this article.
February 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28219077/radiopathological-features-and-identification-of-mycobacterial-infections-in-granulomatous-nodules-resected-from-the-lung
#11
Yumi Sakakibara, Yoshimi Suzuki, Toshihide Fujie, Takumi Akashi, Tadatsune Iida, Yasunari Miyazaki, Yoshinobu Eishi, Naohiko Inase
BACKGROUND: Pulmonary granulomas are sometimes resected because they resemble lung cancer and false-positive findings come through from positron emission tomography (PET) using 18fluorine-fluorodeoxyglucose (18F-FDG). Mycobacterial infection is a common cause of granulomas. OBJECTIVE: The purpose of this study was to evaluate the radiopathological features and the methods for identifying mycobacterial infections in granulomatous nodules resected from the lung. METHODS: Thirty-five solitary lesions resected because of suspected lung cancer were enrolled, including 22 nonfungal granulomatous lesions and 13 benign lesions as controls...
February 21, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28218065/residents-corner-squiz-your-knowledge-a-solitary-asymptomatic-nodule-on-the-arm
#12
Nina Korsaga-Some, Damien Sizaret, Laurent Machet
No abstract text is available yet for this article.
February 1, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28217865/caching-reduces-kleptoparasitism-in-a-solitary-large-felid
#13
Guy A Balme, Jennifer R B Miller, Ross T Pitman, Luke T B Hunter
Food caching is a common strategy used by a diversity of animals, including carnivores, to store and/or secure food. Despite its prevalence, the drivers of caching behaviour, and its impacts on individuals, remain poorly understood, particularly for short-term food cachers. Leopards Panthera pardus exhibit a unique form of short-term food caching, regularly hoisting, storing, and consuming prey in trees. We explored the factors motivating such behaviour among leopards in the Sabi Sand Game Reserve, South Africa, associated with four not mutually exclusive hypotheses: food-perishability, consumption-time, resource-pulse, and kleptoparasitism-avoidance...
February 19, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28217486/skindia-quiz-33-solitary-pigmented-plaque-containing-a-blue-gray-papule
#14
Cody J Connor, Brian L Swick
No abstract text is available yet for this article.
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28217477/solitary-lesion-in-papular-elastorrhexis-a-diagnostic-challenge
#15
Premanshu Bhushan, Sarvesh Thatte, Avninder Singh
No abstract text is available yet for this article.
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28217470/a-case-report-of-reactive-solitary-eccrine-syringofibroadenoma
#16
Anup K Tiwary, J Firdous, Dharmendra K Mishra, Shyam S Chaudhary
Eccrine syringofibroadenoma is a very rare benign tumour of acrosyringium of eccrine sweat duct. Based on the evidences of known etiological factors, two forms have been proposed; reactive and nonreactive. Reactive forms are rarer, and on even rarer occasions, trauma complicated by secondary nonspecific infections may lead to the development of reactive eccrine syringofibroadenoma, as in our case. Here, we are documenting a case of reactive solitary eccrine syringofibroadenoma in a 65-year-old male presenting with coalescing, firm, pinkish, verrucous nodules and painful deep ulceration on the right sole preceded by trauma and secondary infection...
January 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/28217140/evaluation-of-polymerase-chain-reaction-in-space-occupying-lesions-of-liver-reported-as-granulomatous-inflammation-tuberculosis-on-fine-needle-aspiration-cytology
#17
Kusum Sharma, Nalini Gupta, Kapil Goyal, Ajay Kumar Duseja, Aman Sharma, Arvind Rajwanshi
BACKGROUND: Tubercular involvement of the liver is uncommon, but is a serious consideration in differential diagnosis of granulomatous conditions, especially in endemic regions like India. OBJECTIVE: To assess the role of polymerase chain reaction (PCR) done on archival cytological material in diagnosing tuberculosis (TB) in cases reported as granulomatous inflammation/TB in liver lesions. MATERIALS AND METHODS: This was a retrospective study including a total of 17 cases of liver space-occupying lesions (SOLs) reported as granulomatous inflammation (n = 12) and TB (n = 5)...
2017: CytoJournal
https://www.readbyqxmd.com/read/28216928/spontaneous-forniceal-rupture-can-it-be-treated-conservatively
#18
Ahmed Gaber Al-Mujalhem, Mohammed Sayed Ahmed Aziz, Mohammed Farag Sultan, Ahmed Mohammed Al-Maghraby, Mohammed Abdelmonem Al-Shazly
CONTEXT: Spontaneous forniceal rupture is one of the possible complications of urolithiasis. The mechanism of forniceal rupture is not well explained in the literature. Most of the cases presented with sudden onset of acute renal colic and diagnosed by noncontrast CT (NCCT). Until now there is no solid consensus about the ideal management of such a condition. AIM: To study indications and validity of conservative management of spontaneous caliceal rupture. SETTINGS AND DESIGN: This is an observational prospective study...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28216743/solitary-nodule-on-the-thigh
#19
Piyush Kumar, Anupam Das
No abstract text is available yet for this article.
January 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28216742/solitary-subcutaneous-nodule-over-the-right-elbow
#20
Biswanath Behera, Laxmisha Chandrashekar, Devinder Mohan Thappa, Nachiappa Ganesh Rajesh
No abstract text is available yet for this article.
January 2017: Indian Journal of Dermatology
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