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Dendritic cells

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https://www.readbyqxmd.com/read/28655146/ginseng-saponin-rb1-enhances-hematopoietic-function-and-dendritic-cells-differentiation
#1
Li Zhang, Hui Feng, Yibo He, Jinfang Zhao, Yimin Chen, Yonglin Liu
No abstract text is available yet for this article.
June 24, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28654547/dendritic-cell-vaccination-for-metastatic-melanoma-a-14-year-monoinstitutional-experience
#2
Francesco de Rosa, Laura Ridolfi, Laura Fiammenghi, Massimiliano Petrini, Anna M Granato, Valentina Ancarani, Elena Pancisi, Valentina Soldati, Serena Cassan, Jenny Bulgarelli, Massimo Framarini, Francesca Tauceri, Giuseppe Migliori, Claudia Brolli, Giorgia Gentili, Elisabetta Petracci, Oriana Nanni, Angela Riccobon, Ruggero Ridolfi, Massimo Guidoboni
Although immunomodulating antibodies are highly effective in metastatic melanoma, their toxicity, related to the activation of T lymphocytes, can be severe. Anticancer vaccines promote a fairly specific response and are very well tolerated, but their effectiveness has yet to be demonstrated. We have been treating patients with advanced melanoma with an autologous dendritic cell vaccine since 2001; to better characterize the safety and efficacy of our product, we designed a retrospective study on all of our patients treated with the vaccine to date...
August 2017: Melanoma Research
https://www.readbyqxmd.com/read/28654469/the-histopathological-spectrum-of-pseudolymphomatous-infiltrates-in-cutaneous-lupus-erythematosus
#3
Amanda Pereira, Gerardo Ferrara, Paola Calamaro, Carlo Cota, Cesare Massone, Francesca Boggio, Lucia Prieto-Torres, Lorenzo Cerroni
The occurrence of pseudolymphomatous infiltrates in cutaneous lupus erythematosus (cLE) is described mainly in lupus panniculitis and lupus tumidus/lymphocytic infiltration of the skin (Jessner-Kanof). We collected 15 cases of pseudolymphomatous cLE other than lupus panniculitis and lupus tumidus (M:F = 4:11; age range: 23-79 years; mean age: 50.9 years; median age: 57 years). Of the 15 cases, 9 (60%) were characterized by dense nodular infiltrates. Three cases (20%) showed an angiocentric pattern with cytological atypia of lymphoid cells; 2 cases (13...
June 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28654384/fluorescent-plasmonic-and-radiotherapeutic-properties-of-the-177-lu-dendrimer-aunp-folate-bombesin-nanoprobe-located-inside-cancer-cells
#4
Héctor Mendoza-Nava, Guillermina Ferro-Flores, Flor de María Ramírez, Blanca Ocampo-García, Clara Santos-Cuevas, Erika Azorín-Vega, Nallely Jiménez-Mancilla, Myrna Luna-Gutiérrez, Keila Isaac-Olivé
The integration of fluorescence and plasmonic properties into one molecule is of importance in developing multifunctional imaging and therapy nanoprobes. The aim of this research was to evaluate the fluorescent properties and the plasmonic-photothermal, therapeutic, and radiotherapeutic potential of (177)Lu-dendrimer conjugated to folate and bombesin with gold nanoparticles in the dendritic cavity ((177)Lu-DenAuNP-folate-bombesin) when it is internalized in T47D breast cancer cells. The intense near-Infrared (NIR) fluorescence emitted at 825 nm from the conjugate inside cells corroborated the usefulness of DenAuNP-folate-bombesin for optical imaging...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28653223/multi-targeted-therapy-of-everolimus-in-kaposi-s-sarcoma-associated-herpes-virus-infected-primary-effusion-lymphoma
#5
Suchitra Mohanty, Amit Kumar, Piyanki Das, Sushil Kumar Sahu, Tathagata Choudhuri
Kaposi's sarcoma associated herpes virus (KSHV) infected primary effusion lymphoma (PEL) is a rare aggressive form of non-Hodgkin's lymphoma of B cells. KSHV latent and lytic antigens modulate several host cellular signalling pathways especially mammalian target of rapamycin (mTOR), STAT-3 and nuclear factor-kappa B (NF-κB) for rapid tumor progression and immune evasion. Current chemotherapeutic strategies are becoming ineffective as they kill only dividing cells and inefficient to target molecular pathways crucial for active virus replication and its survival...
June 26, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28653001/follicular-dendritic-cell-sarcoma-of-the-liver-with-metachronous-small-bowel-and-splenic-metastases-a-case-report-and-literature-review
#6
Ken Min Chin, Woon Yang Ho, Kiat Hon Tony Lim, Yaw Fui Alexander Chung, Ser Yee Lee
Follicular dendritic cell sarcoma (FDCS) of the liver is an extremely rare disease, accounting for a mere 0.4% of all soft tissue sarcomas. FDCS most commonly involves lymph nodes but also affects extranodal sites such as the gastrointestinal system, oral cavity, liver, spleen and pancreas, albeit less commonly. It is widely considered a low-to-intermediate grade malignancy. We report a case of FDCS with metachronous involvement of the liver, small intestines and spleen, its imaging, histological findings and its management...
June 2017: Hepatobiliary Surgery and Nutrition
https://www.readbyqxmd.com/read/28652625/dendritic-mitoflash-as-a-putative-signal-for-stabilizing-long-term-synaptic-plasticity
#7
Zhong-Xiao Fu, Xiao Tan, Huaqiang Fang, Pak-Ming Lau, Xianhua Wang, Heping Cheng, Guo-Qiang Bi
Mitochondrial flashes (mitoflashes) are recently discovered excitable mitochondrial events in many cell types. Here we investigate their occurrence in the context of structural long-term potentiation (sLTP) at hippocampal synapses. At dendritic spines stimulated by electric pulses, glycine, or targeted glutamate uncaging, induction of sLTP is associated with a phasic occurrence of local, quantized mitochondrial activity in the form of one or a few mitoflashes, over a 30-min window. Low-dose nigericin or photoactivation that elicits mitoflashes stabilizes otherwise short-term spine enlargement into sLTP...
June 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28652571/discovery-of-long-range-inhibitory-signaling-to-ensure-single-axon-formation
#8
Tetsuya Takano, Mengya Wu, Shinichi Nakamuta, Honda Naoki, Naruki Ishizawa, Takashi Namba, Takashi Watanabe, Chundi Xu, Tomonari Hamaguchi, Yoshimitsu Yura, Mutsuki Amano, Klaus M Hahn, Kozo Kaibuchi
A long-standing question in neurodevelopment is how neurons develop a single axon and multiple dendrites from common immature neurites. Long-range inhibitory signaling from the growing axon is hypothesized to prevent outgrowth of other immature neurites and to differentiate them into dendrites, but the existence and nature of this inhibitory signaling remains unknown. Here, we demonstrate that axonal growth triggered by neurotrophin-3 remotely inhibits neurite outgrowth through long-range Ca(2+) waves, which are delivered from the growing axon to the cell body...
June 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28652396/tlr7-signaling-regulates-th17-cells-and-autoimmunity-novel-potential-for-autoimmune-therapy
#9
Jian Ye, Yadan Wang, Xia Liu, Lingyun Li, Adeleye Opejin, Eddy C Hsueh, Huanle Luo, Tian Wang, Daniel Hawiger, Guangyong Peng
Innate regulation through TLR signaling has been shown to be important for promoting T cell subset development and function. However, limited information is known about whether differential TLR signaling can selectively inhibit Th17 and/or Th1 cells, which are important for controlling excessive inflammation and autoimmune responses. In this article, we demonstrate that activation of TLR7 signaling in T cells can inhibit Th17 cell differentiation from naive T cells and IL-17 production in established Th17 cells...
June 26, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28651910/taming-the-immune-system-through-transfusion-in-oncology-patients
#10
REVIEW
Seyed Mohammad Amin Kormi, Jerard Seghatchian
Blood transfusion is a clinical replacement therapy with many successes with some benefit and, also, some harm. Cancer is a multifaceted disease potentially associated with the immune system's weakness where the cancerous tumor cells escape from the immune system. Allogeneic blood transfusion, through five major mechanisms including the lymphocyte-T set, myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), natural killer cells (NKCs), and dendritic cells (DCs) can help the recipient's defense mechanisms...
May 26, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28651542/evidence-for-an-early-innate-immune-response-in-the-motor-cortex-of-als
#11
Javier H Jara, Barış Genç, Macdonell J Stanford, Peter Pytel, Raymond P Roos, Sandra Weintraub, M Marsel Mesulam, Eileen H Bigio, Richard J Miller, P Hande Özdinler
BACKGROUND: Recent evidence indicates the importance of innate immunity and neuroinflammation with microgliosis in amyotrophic lateral sclerosis (ALS) pathology. The MCP1 (monocyte chemoattractant protein-1) and CCR2 (CC chemokine receptor 2) signaling system has been strongly associated with the innate immune responses observed in ALS patients, but the motor cortex has not been studied in detail. METHODS: After revealing the presence of MCP1 and CCR2 in the motor cortex of ALS patients, to elucidate, visualize, and define the timing, location and the extent of immune response in relation to upper motor neuron vulnerability and progressive degeneration in ALS, we developed MCP1-CCR2-hSOD1(G93A) mice, an ALS reporter line, in which cells expressing MCP1 and CCR2 are genetically labeled by monomeric red fluorescent protein-1 and enhanced green fluorescent protein, respectively...
June 26, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28651250/a-role-for-neuronal-alpha-synuclein-in-gastrointestinal-immunity
#12
Ethan Stolzenberg, Deborah Berry, De Yang, Ernest Y Lee, Alexander Kroemer, Stuart Kaufman, Gerard C L Wong, Joost J Oppenheim, Supti Sen, Thomas Fishbein, Ad Bax, Brent Harris, Denise Barbut, Michael A Zasloff
BACKGROUND: Alpha-synuclein (αS) is a nerve cell protein associated with Parkinson disease (PD). Accumulation of αS within the enteric nervous system (ENS) and its traffic from the gut to the brain are implicated in the pathogenesis and progression of PD. αS has no known function in humans and the reason for its accumulation within the ENS is unknown. Several recent studies conducted in rodents have linked αS to immune cell activation in the central nervous system. We hypothesized that αS in the ENS might play a role in the innate immune defenses of the human gastrointestinal (GI) tract...
June 27, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28650480/lineage-specification-of-human-dendritic-cells-is-marked-by-irf8-expression-in-hematopoietic-stem-cells-and-multipotent-progenitors
#13
Jaeyop Lee, Yu Jerry Zhou, Wenji Ma, Wanwei Zhang, Arafat Aljoufi, Thomas Luh, Kimberly Lucero, Deguang Liang, Matthew Thomsen, Govind Bhagat, Yufeng Shen, Kang Liu
The origin and specification of human dendritic cells (DCs) have not been investigated at the clonal level. Through the use of clonal assays, combined with statistical computation, to quantify the yield of granulocytes, monocytes, lymphocytes and three subsets of DCs from single human CD34(+) progenitor cells, we found that specification to the DC lineage occurred in parallel with specification of hematopoietic stem cells (HSCs) to the myeloid and lymphoid lineages. This started as a lineage bias defined by specific transcriptional programs that correlated with the combinatorial 'dose' of the transcription factors IRF8 and PU...
June 26, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28649247/an-antigen-presenting-and-apoptosis-inducing-polymer-microparticle-prolongs-alloskin-graft-survival-by-selectively-and-markedly-depleting-alloreactive-cd8-t-cells
#14
Wei Wang, Khawar Ali Shahzad, Miaochen Li, Aifeng Zhang, Lei Zhang, Tao Xu, Xin Wan, Chuanlai Shen
Selectively depleting the pathogenic T cells is a fundamental strategy for the treatment of allograft rejection and autoimmune disease since it retains the overall immune function of host. The concept of killer artificial antigen-presenting cells (KaAPCs) has been developed by co-coupling peptide-major histocompatibility complex (pMHC) multimer and anti-Fas monoclonal antibody (mAb) onto the polymeric microparticles (MPs) to induce the apoptosis of antigen-specific T cells. But little information is available about its in vivo therapeutic potential and mechanism...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28649195/modulating-stdp-balance-impacts-the-dendritic-mosaic
#15
Nicolangelo Iannella, Thomas Launey
The ability for cortical neurons to adapt their input/output characteristics and information processing capabilities ultimately relies on the interplay between synaptic plasticity, synapse location, and the nonlinear properties of the dendrite. Collectively, they shape both the strengths and spatial arrangements of convergent afferent inputs to neuronal dendrites. Recent experimental and theoretical studies support a clustered plasticity model, a view that synaptic plasticity promotes the formation of clusters or hotspots of synapses sharing similar properties...
2017: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/28648976/synergistic-combination-of-murine-bone-marrow-derived-dendritic-cells-loaded-ex-vivo-with-whole-tumor-lysate-and-systemic-chemotherapy-mediates-antitumor-immune-responses-in-vivo
#16
Mohamed L Salem, Mohamed Nassef, Soha Gomaa, Ibrahim Essa
In order to get mature dendritic cells (DC) that is a crucial prerequisite for success in tumor immunotherapy protocols. Herein, we assumed that administration of murine bone marrow (BM)-derived DC (BM-DC), loaded ex vivo with whole Ehrlich ascites carcinoma (EAC) lysate, in the context of systemic chemotherapy cyclophosphamide (CTX) to induce antitumor immune responses, may be a good strategy to improve the presentation of tumor-specific antigens to the immune system. In the first series of experiments, BM cells generated either from BM of naïve mice or from BM of EAC-bearing mice were cultured in the presence of GM-CSF and IL-4 for 6days...
June 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28648936/diagnostic-pathology-of-alzheimer-s-disease-from-routine-microscopy-to-immunohistochemistry-and-experimental-correlations
#17
Gerard Nuovo, Bernard Paniccia, Louisa Mezache, Maria Quiñónez, James Williams, Paige Vandiver, Paolo Fadda, Vicky Amann
The absence of any histologic correlate for Alzheimer's disease despite its commonness and severe clinical sequelae may offers clues to its etiology. Recent evidence strongly suggests that the central event of this disease is the hyperphosphorylation of neuronal tau protein and not the beta amyloid precipitates. In each case, essential and soluble neuronal proteins derivatives form insoluble aggregates that can readily be detected by immunohistochemistry using antibodies specific for the misfolded proteins...
June 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28648905/antibodies-against-immune-checkpoint-molecules-restore-functions-of-tumor-infiltrating-t-cells-in-hepatocellular-carcinomas
#18
Guoying Zhou, Dave Sprengers, Patrick P C Boor, Michail Doukas, Hannah Schutz, Shanta Mancham, Alexander Pedroza-Gonzalez, Wojciech G Polak, Jeroen de Jonge, Marcia Gaspersz, Haidong Dong, Kris Thielemans, Qiuwei Pan, Jan N M IJzermans, Marco J Bruno, Jaap Kwekkeboom
BACKGROUND & AIMS: Ligand binding to inhibitory receptors on immune cells, such as programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte associated protein 4 (CTLA4), downregulates the T-cell-mediated immune response (called immune checkpoints). Antibodies that block these receptors increase anti-tumor immunity in patients with melanoma, non-small cell lung cancer, and renal cell cancer. Tumor-infiltrating CD4(+) and CD8(+) T cells in patients with hepatocellular carcinoma (HCC) have been found to be functionally compromised...
June 22, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28648868/immune-modulating-effects-in-mouse-dendritic-cells-of-lactobacilli-and-bifidobacteria-isolated-from-individuals-following-omnivorous-vegetarian-and-vegan-diets
#19
Diomira Luongo, Lucia Treppiccione, Alida Sorrentino, Ilario Ferrocino, Silvia Turroni, Monica Gatti, Raffaella Di Cagno, Yolanda Sanz, Mauro Rossi
Lactobacilli and bifidobacteria play a primary role in modulation of gut immunity. By considering that microbiota composition depends on various factors, including diet, we asked whether functional differences could characterize faecal populations of lactobacilli and bifidobacteria isolated from individuals with different dietary habits. 155 healthy volunteers who followed omnivorous, ovo-lacto-vegetarian or vegan diets were recruited at four Italian centres (Turin, Parma, Bologna and Bari). Faecal samples were collected; lactobacilli and bifidobacteria were isolated on selective media and their immunomodulatory activity was tested in mouse dendritic cells (DCs)...
June 22, 2017: Cytokine
https://www.readbyqxmd.com/read/28648044/dendrons-and-multiarm-polymers-with-thiol-exchangeable-cores-a-reversible-conjugation-platform-for-delivery
#20
Ozgul Gok, Pelin Erturk, Burcu Sumer Bolu, Tugce Nihal Gevrek, Rana Sanyal, Amitav Sanyal
Disulfide exchange reaction has emerged as a powerful tool for reversible conjugation of proteins, peptides and thiol containing molecules to polymeric supports. In particular, the pyridyl disulfide group provides an efficient handle for the site-specific conjugation of therapeutic peptides and proteins bearing cysteine moieties. In this study, novel biodegradable dendritic platforms containing a pyridyl disulfide unit at their focal point were designed. Presence of hydroxyl groups at the periphery of these dendrons allows their elaboration to multivalent initiators that yield poly(ethylene glycol) based multiarm star polymers via controlled radical polymerization...
June 24, 2017: Biomacromolecules
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