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https://www.readbyqxmd.com/read/27910180/internal-migration-and-maternal-health-service-utilisation-in-jiangsu-china
#1
Hai Gu, Hua You, Weiqing Ning, Hua Zhou, Jianming Wang, Ying Lu, Jun Sun, Yun Kou, Hengjin Dong
OBJECTIVES: To investigate the use of maternal health care services by internal migrants in view of their migration status. METHODS: Cross-sectional household survey in two cities of Jiangsu Province. Questions elicited data on socioeconomic information and MHC service use (pre-natal examination, post-natal visit, pre-natal health education). Chi-square tests and multivariate logistic regression analyses were used to identify factors associated with MHC service use...
November 5, 2016: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/27891327/analysis-of-fetal-palate-to-assist-pre-natal-ultrasound
#2
Anjali Shastry, Yogitha Ravindranath, Roopa Ravindranath
INTRODUCTION: Cleft palate is one of the major facial congenital malformation in newborns. Pre-natal detection of this malformation is limited to detection of clefting of hard palate but isolated soft palate clefting still remains challenge for sonologists. As Indian literature is limited present study was attempted to provide dimensions and position of fetal palate by digitized images. AIM: To study dimensions, position and differences in parameters between second and third trimester fetuses...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27856333/novel-homozygous-missense-mutation-in-aldh7a1-causes-neonatal-pyridoxine-dependent-epilepsy
#3
Emanuele G Coci, Luca Codutti, Christian Fink, Sophie Bartsch, Gunnar Grüning, Thomas Lücke, Ingo Kurth, Joachim Riedel
Pyridoxine dependent epilepsy (PDE) (OMIM#266100) is a neonatal form of epilepsy, caused by dysfunction of the enzyme α-aminoadipic semialdehyde dehydrogenase (ALDH7A1 or Antiquitin). This enzyme converts α-aminoadipic semialdehyde (α-AASA) into α-aminoadipate (AAA), a critical step in the lysine metabolism of the brain. ALDH7A1 dysfunction causes an accumulation of α-AASA and δ(1)-piperideine-6-carboxylic acid (P6C), which are in equilibrium with each other. P6C binds and inactivates pyridoxal 5'-phosphate (PLP), the active form of pyridoxine...
November 14, 2016: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/27856159/pre-implantation-genetic-diagnosis
#4
REVIEW
Joanne Traeger-Synodinos
The aim of pre-implantation genetic diagnosis (PGD) is to characterize the genetic status of the cells (usually single cells) that have been biopsied from oocytes/zygotes or embryos created in vitro during assisted reproductive treatment. PGD is a multi-step procedure that requires close collaboration between gynaecologists who are experts in assisted reproduction, embryologists who are experts in micromanipulation of germ cells and in embryo biopsy and geneticists who are experts in genetic analysis at the single-cell level...
October 26, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27847257/new-trend-in-the-epidemiology-of-thalassaemia
#5
REVIEW
Chi-Kong Li
Thalassaemia is the most common monogenic disorder worldwide. It is common in areas with prevalent malaria as thalassaemic red cells provide immunity against the parasite. The incidence of thalassaemia carriers is high in regions such as Mediterranean, Middle East, Indian subcontinent, Southeast Asia and South China. In the past few decades, migrants from the thalassaemia prevalent countries to non-prevalent countries, mainly North America and Central and North Europe, are rapidly increasing in number. The non-prevalent countries may not have established pre-natal screening system for thalassaemia...
October 26, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27824070/modeling-the-development-of-the-post-natal-mouse-thymus-in-the-absence-of-bone-marrow-progenitors
#6
Daniela Zaharie, Radu D Moleriu, Felix A Mic
Many mathematical models have been published with the purpose of explaining aspects of T-cell development in the thymus. In this manuscript we adapted a four-compartment model of the thymus and used a range of mathematical approaches with the aim of explaining the dynamics of the four main thymocyte populations in the mouse thymus, from the emergence of the first fetal thymocyte until the death of the animal. At various pre-natal and post-natal stages we investigated experimentally the number and composition of thymocytes populations, their apoptosis and proliferation, along with data from literature, to create and validate the model...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27809754/haemophilia-b-curative-fix-production-from-a-low-dose-ucoe-based-lentiviral-vector-following-hepatic-pre-natal-delivery
#7
Vincent Yu-Cheng Kao, Sonia Ferreira, Simon Nicholas Waddington, Michael Nicholas Antoniou
The ubiquitous chromatin opening element from the human HNRPA2B1-CBX3 housekeeping gene locus (A2UCOE) is able to provide stable and cell-to-cell reproducible levels of transgene expression regardless of target cell genome integration site with efficacy demonstrated in adult, embryonic and induced pluripotent stem cells and their differentiated progeny in vitro and in vivo. Here we evaluate the ability of A2UCOE-based lentiviral vectors to confer stable expression following pre-natal delivery in mice. Our results show stable post-natal A2UCOE-eGFP and A2UCOE-luciferase lentiviral vector presence in both the liver and haematopoietic system with concomitant persistence of expression demonstrating efficient transduction of both fetal hepatocytes and haematopoietic stem cells...
November 2, 2016: Current Gene Therapy
https://www.readbyqxmd.com/read/27807368/expression-of-the-fetal-hematopoiesis-regulator-fev-indicates-leukemias-of-prenatal-origin
#8
T-H Liu, Y-J Tang, Y Huang, L Wang, X-L Guo, J-Q Mi, L-G Liu, H Zhu, Y Zhang, L Chen, X Liu, L-H Zhang, Q-J Ye, B-S Li, J-Y Tang, A Ford, T Enver, F Liu, G-Q Chen, D-L Hong
The origin of cancers is associated with etiology as well as therapeutics. Several studies reveal that malignancies in children can originate in utero. However a diagnostic approach to distinguish between cancers initiated pre- or postnatally is absent. Here we identified a transcriptional factor FEV that was expressed in fetal hematopoietic cells and became silent after birth. We characterized that FEV was essential for the self-renewal of hematopoietic stem cells (HSCs). We next found FEV was expressed in most infant leukemia samples, but not in adult samples, in accord with the known pre-natal origins of the former...
November 3, 2016: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/27784215/epigenetic-effects-of-environmental-chemicals-on-reproductive-biology
#9
Maria Strazzullo, Maria Rosaria Matarazzo
Mammalian reproduction is a complex phenomenon. Human fertility is highly impacted from environmental exposure to toxicants as well as nutrients. The burden of environmental stimuli is heavy and multifaceted. The contaminant sources are many, often occult, and at present, the wide range of positive and negative consequences on the ecosystem and the human health is only partially understood. Compounds deriving from industrial manufacturing, pesticides, waste accumulation and burning are only some examples of the contaminants daily impacting human life...
October 25, 2016: Current Drug Targets
https://www.readbyqxmd.com/read/27783714/women-s-care-during-home-visits-for-the-first-comprehensive-healthcare-week
#10
Laura Lucinda Bezerra Silva, Katia Virginia Oliveira Feliciano, Lorena Novaes Ferraz Pacheco Oliveira, Evelyne Nascimento Pedrosa, Maria Suely Medeiros Corrêa, Ariani Impieri Souza
Objective: To evaluate women's care during home visits for the "First Comprehensive Care Week". Method: A cross-sectional study was carried out in a specialized service in Recife, Pernambuco, Brazil. A total of 190 women who had recently given birth enrolled at the Family Health Strategy answered the questionnaire between September and December 2013 to verify the association between home visits and the investigated variables. This association was verified using the chi-square test with a confidence level of 95%...
October 24, 2016: Revista Gaúcha de Enfermagem
https://www.readbyqxmd.com/read/27768967/the-impact-of-maternal-adiposity-specialization-on-infant-birthweight-upper-versus-lower-body-fat
#11
Alexandra C Sundermann, Troy D Abell, Lisa C Baker, Mark B Mengel, Kathryn E Reilly, Michael A Bonow, Gregory E Hoy, Richard D Clover
BACKGROUND: The specialization of human fat deposits is an inquiry of special importance in the study of fetal growth. It has been theorized that maternal lower-body fat is designated specifically for lactation and not for the growth of the fetus. OBJECTIVE: Our goal was to compare the contributions of maternal upper-body versus lower-body adiposity to infant birth weight. We hypothesized that upper-body adiposity would be strongly associated with infant birth weight and that lower-body adiposity would be weakly or negligibly associated with infant birth weight-after adjusting for known determinants...
September 21, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27759818/frequency-and-risk-factors-for-the-birth-of-small-for-gestational-age-newborns-in-a-public-maternity-hospital
#12
Marina Parca Cavelagna Teixeira, Tatiana Peloso Reis Queiroga, Maria Dos Anjos Mesquita
Objective: To determine the frequency and risk factors of small-for-gestational-age newborns in a high-risk maternity. Methods: This is an observational, cross-sectional, and case-control study, conducted in a public tertiary care maternity hospital. Data from 998 newborns and their mothers were collected through interviews and review of medical records and prenatal care cards. Some placentas underwent histopathological analysis. The variables of small-for-gestational-age and non-small-for-gestational-age newborns and of their mothers were statistically compared by means of Student's t test, Fisher's exact test, and odds ratio...
July 2016: Einstein
https://www.readbyqxmd.com/read/27729066/pre-natal-exposures-and-breast-tissue-composition-findings-from-a-british-pre-birth-cohort-of-young-women-and-a-systematic-review
#13
Rachel Denholm, Bianca De Stavola, John H Hipwell, Simon J Doran, Marta C Busana, Amanda Eng, Mona Jeffreys, Martin O Leach, David Hawkes, Isabel Dos Santos Silva
BACKGROUND: Breast density, the amount of fibroglandular tissue in the adult breast for a women's age and body mass index, is a strong biomarker of susceptibility to breast cancer, which may, like breast cancer risk itself, be influenced by events early in life. In the present study, we investigated the association between pre-natal exposures and breast tissue composition. METHODS: A sample of 500 young, nulliparous women (aged approximately 21 years) from a U...
October 12, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27721317/analysis-of-the-relationship-between-the-month-of-birth-and-risk-of-multiple-sclerosis-in-a-spanish-population
#14
Rocío N Villar-Quiles, Jordi A Matías-Guiu, Gloria Ortega, Inés González-Suárez, Celia Oreja-Guevara, Jorge Matías-Guiu
BACKGROUND: Some studies have suggested an association between the month of birth and risk of multiple sclerosis (MS), related to environmental factors, mainly sun exposure and maternal vitamin D levels. Few studies have been conducted in Southern Europe countries. Madrid has a continental climate with considerable variation of sun hours between winter and summer, so it may be relevant to study this relationship. METHODS: MS patients, born between 1932 and 2003, 1,335 of them from our database between 2004 and 2015, were analysed...
2016: European Neurology
https://www.readbyqxmd.com/read/27687906/early-nutrition-growth-and-cognitive-development-of-infants-from-birth-to-2%C3%A2-years-in-malaysia-a-study-protocol
#15
Abdul Razak Nurliyana, Zalilah Mohd Shariff, Mohd Nasir Mohd Taib, Wan Ying Gan, Kit-Aun Tan
BACKGROUND: The first 2 years of life is a critical period of rapid growth and brain development. During this period, nutrition and environmental factors play important roles in growth and cognitive development of a child. This report describes the study protocol of early nutrition, growth and cognitive development of infants from birth to 2 years of age. METHODS/DESIGN: This is a prospective cohort study of mothers and infants recruited from government health clinics in Seremban district in Negeri Sembilan, Malaysia...
September 29, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27645456/maternal-immunization-with-pneumococcal-polysaccharide-vaccine-persistence-of-maternal-antibodies-in-infants
#16
Eitan N Berezin, Claudia C Lopes, Maria Regina A Cardoso
OBJECTIVE: To evaluate the level and the persistence of maternal antibodies in infants after maternal immunization with pneumococcal polysaccharide vaccine (Pn23V). METHODS: Pregnant women were assigned to two groups, during routine low-risk pre-natal visits. The first Group (VAC) received the Pn23V vaccine shortly after enrolment at 28 weeks or later, and the second Group (NO_VAC) received no vaccine. To investigate the antibody persistence, we collected blood samples from the mothers after 1 month of delivery and from the infants at 1 and 6 months of age...
September 18, 2016: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/27613228/the-effects-of-maternal-under-nutrition-and-a-post-natal-high-fat-diet-on-lens-growth-transparency-and-oxidative-defense-systems-in-rat-offspring
#17
Sachini K Jayaratne, Paul J Donaldson, Mark H Vickers, Julie C Lim
PURPOSE: A poor early life nutrition environment is well established to result in a range of cardiometabolic disorders in offspring in later life. These effects can be exacerbated via exposure to an obesogenic dietary environment. To date, the effect of maternal diet and/or a post-natal obesogenic nutritional environment on key characteristics related to lens growth and oxidative stress has not been undertaken. The present study, therefore, examined the characteristics and oxidative status of the lens...
September 9, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27610624/comparison-of-human-neonatal-and-adult-blood-leukocyte-subset-composition-phenotypes
#18
Savit B Prabhu, Deepak K Rathore, Deepa Nair, Anita Chaudhary, Saimah Raza, Parna Kanodia, Shailaja Sopory, Anna George, Satyajit Rath, Vineeta Bal, Reva Tripathi, Siddharth Ramji, Aruna Batra, Kailash C Aggarwal, Harish K Chellani, Sugandha Arya, Nidhi Agarwal, Umesh Mehta, Uma Chandra Mouli Natchu, Nitya Wadhwa, Shinjini Bhatnagar
The human peripheral leukocyte subset composition depends on genotype variation and pre-natal and post-natal environmental influence diversity. We quantified this composition in adults and neonates, and compared the median values and dispersal ranges of various subsets in them. We confirmed higher frequencies of monocytes and regulatory T cells (Tregs), similar frequencies of neutrophils, and lower frequencies of CD8 T cells, NKT cells, B1 B cells and gamma-delta T cells in neonatal umbilical cord blood. Unlike previous reports, we found higher frequencies of eosinophils and B cells, higher CD4:CD8 ratios, lower frequencies of T cells and iNKT cells, and similar frequencies of CD4 T cells and NK cells in neonates...
2016: PloS One
https://www.readbyqxmd.com/read/27602285/temporal-dynamics-of-the-developing-lung-transcriptome-in-three-common-inbred-strains-of-laboratory-mice-reveals-multiple-stages-of-postnatal-alveolar-development
#19
Kyle J Beauchemin, Julie M Wells, Alvin T Kho, Vivek M Philip, Daniela Kamir, Isaac S Kohane, Joel H Graber, Carol J Bult
To characterize temporal patterns of transcriptional activity during normal lung development, we generated genome wide gene expression data for 26 pre- and post-natal time points in three common inbred strains of laboratory mice (C57BL/6J, A/J, and C3H/HeJ). Using Principal Component Analysis and least squares regression modeling, we identified both strain-independent and strain-dependent patterns of gene expression. The 4,683 genes contributing to the strain-independent expression patterns were used to define a murine Developing Lung Characteristic Subtranscriptome (mDLCS)...
2016: PeerJ
https://www.readbyqxmd.com/read/27601722/does-early-life-diet-affect-longevity-a-meta-analysis-across-experimental-studies
#20
Sinead English, Tobias Uller
Life-history theory predicts that nutrition influences lifespan owing to trade-offs between allocating resources to reproduction, growth and repair. Despite occasional reports that early diet has strong effects on lifespan, it is unclear whether this prediction is generally supported by empirical studies. We conducted a meta-analysis across experimental studies manipulating pre- or post-natal diet and measuring longevity. We found no overall effect of early diet on lifespan. We used meta-regression, considering moderator variables based on experimental and life-history traits, to test predictions regarding the strength and direction of effects that could lead to positive or negative effects...
September 2016: Biology Letters
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