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https://www.readbyqxmd.com/read/28102445/-congenital-nevus-atypical-spitz-nevus-or-spitzoid-melanoma
#1
A Blum, M Tanaka, K S Kraemer-Schultheiss, J Bauer
No abstract text is available yet for this article.
January 19, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28099273/making-the-most-of-hypomethylating-agents-in-myelodysplastic-syndrome
#2
Geetika Bhatt, William Blum
PURPOSE OF REVIEW: Hypomethylating agents (HMA) are the preferred therapy for patients with higher risk myelodysplastic syndromes (MDS) and an alternative therapeutic strategy for older patients with acute myeloid leukemia. These agents have improved both survival and quality of life, but results overall remain poor. The purpose of this review is to highlight recent developments in clinical research with HMA in MDS/acute myeloid leukemia over the last year. RECENT FINDINGS: Combination of HMA with B-cell lymphoma-2 inhibitors, hedgehog inhibitors, and a variety of other agents are underway, as are further studies with reformulated HMA that have more favorable pharmacokinetics (including oral bioavailability)...
January 17, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28099271/innovative-strategies-for-adverse-karyotype-acute-myeloid-leukemia
#3
Sabine Blum, Gabriele Greve, Michael Lübbert
PURPOSE OF REVIEW: Adverse karyotype acute myeloid leukemia is a disease particularly of older patients, but also observed in younger patients. Despite all efforts, standard chemotherapy is still generally applied in fit patients, as already for decades, and for nearly all different subtypes of acute myeloid leukemia. Lack of more specifically targeted therapy and the often older age of the patients are complicating treatment, and in the subgroup of patients achieving a complete remission, the strikingly high frequency of relapse is a characteristic of this disease...
January 17, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28090618/alan-blum-on-why-physicians-need-to-be-more-active-and-creative-in-the-clinic-classroom-and-community-in-smoking-prevention-and-cessation
#4
Alan Blum
No abstract text is available yet for this article.
January 15, 2017: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/28090374/neurophysiological-measures-and-alcohol-use-disorder-aud-hypothesizing-links-between-clinical-severity-index-and-molecular-neurobiological-patterns
#5
Mario Vitali, Carmen Napolitano, Marlene Oscar Berman, Simona Flamminii Minuto, Gemma Battagliese, Maria Luisa Attilia, Eric R Braverman, Marina Romeo, Kenneth Blum, Mauro Ceccanti
BACKGROUND: In 1987, Cloninger proposed a clinical description and classification of different personality traits genetically defined and independent from each other. Moreover, he elaborated a specific test the TCI to investigate these traits/states. The study of craving in Alcohol Use Disorder (AUD) assumed a greater significance, since ever more data seems to suggest a direct correlation between high levels of craving and a higher risk of relapse in alcoholics. Thus, our study aim is to explore the possible correlations among TCI linked molecular neurobiological pattern (s), craving and alcohol addiction severity measures in a sample of Italian alcoholics...
April 2016: Journal of Addiction Research & Therapy
https://www.readbyqxmd.com/read/28087836/neuropathological-consequences-of-gestational-exposure-to-concentrated-ambient-fine-and-ultrafine-particles-in-the-mouse
#6
Carolyn Klocke, Joshua L Allen, Marissa Sobolewski, Margot Mayer-Pröschel, Jason L Blum, Dana Lauterstein, Judith T Zelikoff, Deborah A Cory-Slechta
Increasing evidence indicates that the central nervous system (CNS) is a target of air pollution. We previously reported that postnatal exposure of mice to concentrated ambient ultrafine particles (UFP; ≤100nm) via the University of Rochester HUCAPS system during a critical developmental window of CNS development, equivalent to human 3(rd) trimester, produced male-predominant neuropathological and behavioral characteristics common to multiple neurodevelopmental disorders, including autism spectrum disorder (ASD), in humans...
January 13, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28076771/screening-and-prioritization-of-micropollutants-in-wastewaters-from-on-site-sewage-treatment-facilities
#7
Meritxell Gros, Kristin M Blum, Henrik Jernstedt, Gunno Renman, Sara Rodríguez-Mozaz, Peter Haglund, Patrik L Andersson, Karin Wiberg, Lutz Ahrens
A comprehensive screening of micropollutants was performed in wastewaters from on-site sewage treatment facilities (OSSFs) and urban wastewater treatment plants (WWTPs) in Sweden. A suspect screening approach, using high resolution mass spectrometry, was developed and used in combination with target analysis. With this strategy, a total number of 79 micropollutants were successfully identified, which belong to the groups of per- and polyfluoroalkyl substances (PFASs), pesticides, phosphorus-containing flame retardants (PFRs) and pharmaceuticals and personal care products (PPCPs)...
December 30, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28076704/targt-gene-therapy-platform-for-correction-of-anemia-in-end-stage-renal-disease
#8
LETTER
Shany Blum, Nir Shapir, Reem Miari, Benny Lerner, Belly Koren, Keren Doenyas-Barak, Shai Efrati, Pablo E Pergola, Doron Schwartz, Gil Chernin, Yoram Yagil, Serge Guzy, Abraham Nyska, Garry A Neil
No abstract text is available yet for this article.
12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28073846/extended-treatment-with-single-agent-ibrutinib-at-the-420-mg-dose-leads-to-durable-responses-in-chronic-lymphocytic-leukemia-small-lymphocytic-lymphoma
#9
Steven E Coutré, Richard R Furman, Ian W Flinn, Jan A Burger, Kristie Blum, Jeff Sharman, Jeffrey Jones, William Wierda, Weiqiang Zhao, Nyla A Heerema, Amy J Johnson, Anh Tran, Cathy Zhou, Elizabeth Bilotti, Danelle F James, John C Byrd, Susan O'Brien
PURPOSE: Ibrutinib, a first-in-class, once-daily, oral inhibitor of Bruton tyrosine kinase, promotes apoptosis, and inhibits B-cell proliferation, adhesion, and migration. Ibrutinib has demonstrated single-agent efficacy and acceptable tolerability at doses of 420 and 840 mg in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) who were treatment-naïve (TN) or had relapsed/refractory (R/R) CLL after ≥1 prior therapy in a phase Ib/II study (PCYC-1102). Subsequently, the ibrutinib 420 mg dose was approved in CLL...
January 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28066861/the-incidence-of-cardiomyopathy-in-brca1-and-brca2-mutation-carriers-after-anthracycline-based-adjuvant-chemotherapy
#10
Edward J Pearson, Anju Nair, Yahya Daoud, Joanne L Blum
PURPOSE: Breast cancer remains the fourth-leading cause of death in the United States. Nearly 10% of breast cancers are hereditary, with deleterious mutations in BRCA1 and BRCA2 genes being the leading cause. Anthracycline chemotherapy, used commonly for breast cancer, carries cardiotoxicity risk. Recent studies demonstrated anthracycline-induced cardiac failure in homozygous BRCA2-deficient mice and increased rates of heart failure in homozygous BRCA1-deficient mice following ischemic insult...
January 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28066627/survival-analyses-in-lung-cancer
#11
EDITORIAL
Kari Chansky, Dragan Subotic, Nathan R Foster, Torsten Blum
BACKGROUND: Although survival analyses represent one of the cornerstones in oncology in general, some aspects of the reported survival data in lung cancer patients are still not fully elucidated. METHODS: After having defined several open questions, an evidence based approach was applied in order to answer these questions. Areas of interest were: (I) possible uncertainties in reported survival data; (II) survival surrogates; (III) recommended methods for evaluating progression free survival (PFS) as a surrogate endpoint in future datasets; (IV) postoperative lung cancer recurrence and survival...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28065833/standardizing-abortion-research-outcomes-star-a-protocol-for-developing-disseminating-and-implementing-a-core-outcome-set-for-medical-and-surgical-abortion
#12
Katherine C Whitehouse, Caron R Kim, Bela Ganatra, James M N Duffy, Jennifer Blum, Dalia Brahmi, Mitchell D Creinin, Teresa DePiñeres, Kristina Gemzell-Danielsson, Daniel Grossman, Beverly Winikoff, A Metin Gülmezoglu
BACKGROUND: Abortion is one of the most common events in women's healthcare worldwide. Currently there is no standardization for the selection and reporting of outcomes in abortion clinical trials. This heterogeneity in clinical trials can make it difficult to draw meaningful conclusions across studies. OBJECTIVE: We aim to develop, disseminate, and implement a core outcome set (COS) for medical and surgical abortion trials. MATERIALS & METHODS: To guide this project, we have assembled a local study management team and an international advisory group including abortion providers, researchers, methodologists, and abortion clients...
January 5, 2017: Contraception
https://www.readbyqxmd.com/read/28058843/formation-of-a-k-in-se-surface-species-by-naf-kf-post-deposition-treatment-of-cu-in-ga-se2-thin-film-solar-cell-absorbers
#13
Evelyn Handick, Patrick Reinhard, Regan G Wilks, Fabian Pianezzi, Thomas Kunze, Dagmar Kreikemeyer-Lorenzo, Lothar Weinhardt, Monika Blum, Wanli Yang, Mihaela Gorgoi, Eiji Ikenaga, Dominic Gerlach, Shigenori Ueda, Yoshiyuki Yamashita, Toyohiro Chikyow, Clemens Heske, Stephan Buecheler, Ayodhya N Tiwari, Marcus Bär
A NaF/KF post-deposition treatment (PDT) has recently been employed to achieve new record efficiencies of Cu(In,Ga)Se2 (CIGSe) thin film solar cells. We have used a combination of depth-dependent soft and hard x-ray photoelectron spectroscopy as well as soft x-ray absorption and emission spectroscopy to gain detailed insight into the chemical structure of the CIGSe surface and how it is changed by different PDTs. Alkali-free CIGSe, NaF-PDT CIGSe, and NaF/KF-PDT CIGSe absorbers grown by low-temperature co-evaporation have been interrogated...
January 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28056392/trends-of-classification-incidence-mortality-and-survival-of-mds-patients-in-switzerland-between-2001-and-2012
#14
Nicolas Bonadies, Anita Feller, Alicia Rovo, Axel Ruefer, Sabine Blum, Bernhard Gerber, Georg Stuessi, Rudolf Benz, Nathan Cantoni, Andreas Holbro, Adrian Schmidt, Thomas Lehmann, C Matthias Wilk, Volker Arndt
Myelodysplastic syndromes (MDS) are emerging disorders of the elderly with an increasing burden on healthcare systems. He we report on the first population-based, epidemiological analysis of patients diagnosed with MDS in Switzerland between 2001 and 2012. The aim of this study was to characterize the extent and limitations of currently available population-based, epidemiological data and formulate recommendations for future health services research. The investigated outcomes comprised trends of annual case frequency, classification of morphological subtypes, incidence, mortality and survival...
January 2, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28041991/serial-multilevel-urine-pregnancy-testing-to-assess-medical-abortion-outcome-a-meta-analysis
#15
Elizabeth G Raymond, Tara Shochet, Jennifer Blum, Wendy R Sheldon, Ingrida Platais, Hillary Bracken, Rasha Dabash, Mark A Weaver, Nguyen Thi Nhu Ngoc, Paul D Blumenthal, Beverly Winikoff
OBJECTIVES: To summarize data on the accuracy of a strategy designed to exclude ongoing pregnancy after medical abortion treatment by observing a decline in urine human chorionic gonadotropin (hCG) concentration as estimated by multilevel urine pregnancy tests (MLPTs) performed before and after treatment. STUDY DESIGN: We collated original data from seven studies performed by our organization that evaluated the accuracy of the MLPT strategy for assessment of outcome of medical abortion...
December 29, 2016: Contraception
https://www.readbyqxmd.com/read/28041913/a-three-dimensional-in-vitro-model-to-demonstrate-the-haptotactic-effect-of-monocyte-chemoattractant-protein-1-on-atherosclerosis-associated-monocyte-migration
#16
Neda Ghousifam, Hamid Mortazavian, Rudra Bhowmick, Yolanda Vasquez, Frank D Blum, Heather Gappa-Fahlenkamp
Monocyte transendothelial migration is a multi-step process critical for the initiation and development of atherosclerosis. The chemokine monocyte chemoattractant protein-1 (MCP-1) is overexpressed during atheroma and its concentration gradients in the extracellular matrix (ECM) is critical for the transendothelial recruitment of monocytes. Based on prior observations, we hypothesize that both free and bound gradients of MCP-1 within the ECM are involved in directing monocyte migration. The interaction between a three-dimensional (3D), cell-free, collagen matrix and MCP-1; and its effect on monocyte migration was measured in this study...
December 29, 2016: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28039282/relationships-of-measured-and-genetically-determined-height-with-the-cardiac-conduction-system-in-healthy-adults
#17
Thomas Kofler, Sébastien Thériault, Matthias Bossard, Stefanie Aeschbacher, Selina Bernet, Philipp Krisai, Steffen Blum, Martin Risch, Lorenz Risch, Christine M Albert, Guillaume Paré, David Conen
BACKGROUND: Increasing height is an independent risk factor for atrial fibrillation, but the underlying mechanisms are unknown. We hypothesized that height-related differences in electric conduction could be potential mediators of this relationship. METHODS AND RESULTS: We enrolled 2149 adults aged 25 to 41 years from the general population. Height was directly measured, and a resting 12-lead ECG obtained under standardized conditions. Multivariable linear regression models were used to evaluate the association between measured height and ECG parameters...
January 2017: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/28033474/hypothesizing-that-neuropharmacological-and-neuroimaging-studies-of-glutaminergic-dopaminergic-optimization-complex-kb220z-are-associated-with-dopamine-homeostasis-in-reward-deficiency-syndrome-rds
#18
Kenneth Blum, Marcelo Febo, Lyle Fried, Mona Li, Kristina Dushaj, Eric R Braverman, Thomas McLaughlin, Bruce Steinberg, Rajendra D Badgaiyan
BACKGROUND: There is need for better treatments of addictive behaviors, both substance and non-substance related, termed Reward Deficiency Syndrome (RDS). While the FDA has approved pharmaceuticals under the umbrella term Medication Assisted Treatment (MAT), these drugs are not optimal. OBJECTIVES: It is our contention that these drugs work well in the short-term by blocking dopamine function leading to psychological extinction. However, use of buprenorphine/Naloxone over a long period of time results in unwanted addiction liability, reduced emotional affect, and mood changes including suicidal ideation...
December 29, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/28012032/abdominal-wall-reinforcement-biologic-vs-degradable-synthetic-devices
#19
S Gruber-Blum, J Brand, C Keibl, R H Fortelny, H Redl, F Mayer, A H Petter-Puchner
BACKGROUND: New biodegradable synthetic and biologic hernia implants have been promoted for rapid integration and tissue reinforcement in challenging repairs, e.g. at the hiatus or in contaminated wound fields. Interestingly, experimental data to support or falsify this assumption is scarce. METHODS: Synthetic (BioA(®)) and biologic implants (porcine and bovine collagen matrices Strattice(®) and Veritas(®)) have been tested in experimental onlay hernia repair in rats in observation periods of 30 and 60 days...
December 23, 2016: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/28002818/safety-outcomes-and-near-adult-height-gain-of-growth-hormone-treated-children-with-shox-deficiency-data-from-an-observational-study-and-a-clinical-trial
#20
Imane Benabbad, Myriam Rosilio, Christopher J Child, Jean-Claude Carel, Judith L Ross, Cheri L Deal, Stenvert L S Drop, Alan G Zimmermann, Nan Jia, Charmian A Quigley, Werner F Blum
BACKGROUND/AIMS: To assess auxological and safety data for growth hormone (GH)-treated children with SHOX deficiency. METHODS: Data were examined for GH-treated SHOX-deficient children (n = 521) from the observational Genetics and Neuroendocrinology of Short Stature International Study (GeNeSIS). For patients with near-adult height information, GeNeSIS results (n = 90) were compared with a clinical trial (n = 28) of SHOX-deficient patients. Near-adult height was expressed as standard deviation score (SDS) for chronological age, potentially increasing the observed effect of treatment...
December 22, 2016: Hormone Research in Pædiatrics
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