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https://www.readbyqxmd.com/read/28918268/a-structural-mri-study-of-excoriation-skin-picking-disorder-and-its-relationship-to-clinical-severity
#1
Michael D Harries, Samuel R Chamberlain, Sarah A Redden, Brian L Odlaug, Austin W Blum, Jon E Grant
Excoriation (skin-picking) disorder (SPD) shares symptomology with other obsessive-compulsive and related disorders. Few studies, however, have examined the neurological profile of patients with SPD. This study examined differences in cortical thickness and basal ganglia structural volumes between 20 individuals with SPD and 16 healthy controls using magnetic resonance imaging (MRI). There were no significant differences in demographic variables (age, gender, education and race) between groups. All subjects completed a structural MRI scan and completed a battery of clinical assessments focusing on SPD symptom severity, depression and anxiety symptoms, and quality of life...
September 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28915993/marching-to-a-different-drummer-a-cross-cultural-comparison-of-young-adolescents-who-challenge-gender-norms
#2
Chunyan Yu, Xiayun Zuo, Robert W Blum, Deborah L Tolman, Anna Kågesten, Kristin Mmari, Sara De Meyer, Kristien Michielsen, Sharmistha Basu, Rajib Acharya, Qiguo Lian, Chaohua Lou
PURPOSE: Little is known about how gender norms regulate adolescents' lives across different cultural settings. This study aims to illustrate what is considered as violating gender norms for boys and girls in four urban poor sites as well as the consequences that follow the challenging of gender norms. METHODS: Data were collected as part of the Global Early Adolescent Study, a 15-country collaboration to explore gender norms and health in early adolescence. The current study analyzed narrative and in-depth interviews conducted in urban poor sites in two middle-income (Shanghai, China; and New Delhi, India) and two high-income countries (Baltimore, U...
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28915989/it-begins-at-10-how-gender-expectations-shape-early-adolescence-around-the-world
#3
Robert W Blum, Kristin Mmari, Caroline Moreau
No abstract text is available yet for this article.
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28915986/exploration-of-gender-norms-and-socialization-among-early-adolescents-the-use-of-qualitative-methods-for-the-global-early-adolescent-study
#4
REVIEW
Kristin Mmari, Robert W Blum, Rebkha Atnafou, Elisa Chilet, Sara de Meyer, Omaima El-Gibaly, Sharmista Basu, Bamidele Bello, Beatrice Maina, Xiayun Zuo
PURPOSE: The Global Early Adolescent Study (GEAS) was launched in 2014 with the primary goal of understanding the factors in early adolescence that predispose young people to subsequent sexual risks, and conversely, those that promote healthy sexuality across different cultural contexts. The present article describes the methodology that was used for the first phase of GEAS, which consisted of conducting qualitative research to understand the gendered transitions into adolescence and the role that gender norms play within the key relationships of adolescents...
October 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28915547/persistence-mobility-and-bioavailability-of-emerging-organic-contaminants-discharged-from-sewage-treatment-plants
#5
Kristin M Blum, Patrik L Andersson, Lutz Ahrens, Karin Wiberg, Peter Haglund
Little is known about the impact of emissions of micropollutants from small and large-scale sewage treatment plants (STPs) on drinking water source areas. We investigated a populated catchment that drains into Lake Mälaren, which is the drinking water source for around 2 million people including the inhabitants of Stockholm, Sweden. To assess the persistence, mobility, bioavailability and bioaccumulation of 32 structurally diverse emerging organic contaminants, sediment, integrated passive and grab water samples were collected along the catchment of the River Fyris, Sweden...
September 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28914731/academic-developmental-behavioral-pediatric-faculty-at-developmental-behavioral-pediatric-research-network-sites-changing-composition-and-interests
#6
Nancy Roizen, Ruth E K Stein, Ellen J Silver, Pamela High, Marilyn C Augustyn, Nathan J Blum
OBJECTIVE: To obtain and review workforce data, given the critical demand for developmental pediatricians (DPs). METHODS: Survey of demographics and professional activities of DP physician faculty at Developmental-Behavioral Pediatric (DBP) Research Network fellowship training sites. RESULTS: Of the eligible providers at 12 centers, 76% (n = 50) completed surveys. They were on average 50 years old and mostly female (86%), white (82%), and working full time (74%)...
September 7, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28910530/an-efficient-implicit-solvation-method-for-full-potential-dft
#7
Markus Sinstein, Christoph Scheurer, Sebastian Matera, Volker Blum, Karsten Reuter, Harald Oberhofer
With the advent of efficient electronic structure methods, effective continuum solvation methods have emerged as a way to, at least partially, include solvent effects into simulations without the need for expensive sampling over solvent degrees of freedom. The multipole moment expansion (MPE) model, while based on ideas initially put forward almost 100 years ago, has recently been updated for the needs of modern electronic structure calculations. Indeed, for an all-electron code relying on localized basis sets and---more importantly---a multipole moment expansion of the electrostatic potential, the MPE method presents a particularly cheap way of solving the macroscopic Poisson equation to determine the electrostatic response of a medium surrounding a solute...
September 14, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28906182/multi-locus-sequence-typing-of-streptococcus-equi-subspecies-zooepidemicus-strains-isolated-from-cats
#8
Ann P Britton, Shlomo E Blum, Carolyn Legge, Ken Sojonky, Erin N Zabek
Streptococcus equi subspecies zooepidemicus ( S. zooepidemicus) causes outbreaks of fatal respiratory disease in dog shelters and fatal respiratory and neurologic disease in cat shelters. We conducted multi-locus sequence typing analysis on S. zooepidemicus isolates from 5 Canadian and 3 Israeli cats with severe respiratory and neurologic disease, plus 1 isolate from a clinically normal shelter cat. Our aim was to determine if feline outbreaks are clonal and whether there is commonality between feline and canine strains...
September 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28893721/exposure-to-ambient-particulate-matter-during-specific-gestational-periods-produces-adverse-obstetric-consequences-in-mice
#9
Jason L Blum, Lung-Chi Chen, Judith T Zelikoff
BACKGROUND: Epidemiological studies associate inhalation of fine-sized particulate matter (PM2.5) during pregnancy with preterm birth (PTB) and low birth weight (LBW) but disagree over which time frames are most sensitive, or if effects are cumulative. OBJECTIVES: Our objective was to provide experimental plausibility for epidemiological observations by testing the hypothesis that exposure to PM2.5 during discrete periods of pregnancy results in PTB and LBW. METHODS: For the first study, timed-pregnant B6C3F1 mice were exposed to concentrated ambient PM2...
July 27, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28892589/single-turnover-at-molecular-polymerization-catalysts-reveals-spatiotemporally-resolved-reactions
#10
Suzanne A Blum, Quinn T Easter
Multiple active individual molecular ruthenium catalysts were pinpointed within growing polynorbornene, revealing reaction dynamics and location information that is unavailable through traditional ensemble experiments. These experiments are the first single-turnover fluorescence microscopy imaging at any molecular catalyst and achieve the detection of individual monomer reactions at an industrially important molecular ruthenium ring-opening metathesis polymerization (ROMP) catalyst under synthetically relevant catalytic conditions (e...
September 11, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28890039/legionella-longbeachae-pneumonia-as-a-complication-of-alemtuzumab-therapy
#11
S Boyle, G Olive, N Townell, A Henderson, S Bowler, S Blum
No abstract text is available yet for this article.
September 8, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28887533/creation-and-initial-characterization-of-isogenic-helicobacter-pylori-caga-epiya-variants-reveals-differential-activation-of-host-cell-signaling-pathways
#12
Dacie R Bridge, Faith C Blum, Sungil Jang, Jinmoon Kim, Jeong-Heon Cha, D Scott Merrell
The polymorphic CagA toxin is associated with Helicobacter pylori-induced disease. Previous data generated using non-isogenic strains and transfection models suggest that variation surrounding the C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs as well as the number of EPIYA motifs influence disease outcome. To investigate potential CagA-mediated effects on host cell signaling, we constructed and characterized a large panel of isogenic H. pylori strains that differ primarily in the CagA EPIYA region. The number of EPIYA-C motifs or the presence of an EPIYA-D motif impacted early changes in host cell elongation; however, the degree of elongation was comparable across all strains at later time points...
September 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28885821/isotopic-characterization-of-mercury-downstream-of-historic-industrial-contamination-in-the-south-river-virginia
#13
Spencer John Washburn, Joel D Blum, Jason Demers, Aaron Y Kurz, Richard C Landis
Historic point source mercury (Hg) contamination from industrial processes on the South River (Waynesboro, Virginia) ended decades ago, but elevated Hg concentrations persist in the river system. In an effort to better understand Hg sources, mobility, and transport in the South River, we analyzed total Hg (THg) concentrations and Hg stable isotope compositions of streambed sediments, stream bank soils, suspended particles, and filtered surface waters. Samples were collected along a longitudinal transect of the South River, starting upstream of the historic Hg contamination point-source and extending downstream to the confluence with the South Fork Shenandoah River...
September 8, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28885712/pathological-complete-response-in-patients-with-esophageal-cancer-after-the-trimodality-approach-the-association-with-baseline-variables-and-survival-the-university-of-texas-md-anderson-cancer-center-experience
#14
Mariela Blum Murphy, Lianchum Xiao, Viren R Patel, Dipen M Maru, Arlene M Correa, Fatemeh G Amlashi, Zhongxing Liao, Ritsuko Komaki, Steven H Lin, Heath D Skinner, Ara Vaporciyan, Garrett L Walsh, Stephen G Swisher, Boris Sepesi, Jeffrey H Lee, Manoop S Bhutani, Brian Weston, Wayne L Hofstetter, Jaffer A Ajani
BACKGROUND: Reports are limited regarding clinical and pretreatment features that might predict a pathological complete response (pathCR) after treatment in patients with esophageal cancer (EC). This might allow patient selection for different strategies. This study examines the association of a pathCR with pretreatment variables, overall survival (OS), recurrence-free survival (RFS), and patterns of recurrence in a large cohort from a single institution. METHODS: The baseline clinical features of 911 consecutive patients with EC who were treated with trimodality therapy from January 2000 to November 2013 were analyzed...
September 8, 2017: Cancer
https://www.readbyqxmd.com/read/28881418/population-pharmacokinetic-evaluation-and-missed-dose-simulations-for-eslicarbazepine-acetate-monotherapy-in-patients-with-partial-onset-seizures
#15
Soujanya Sunkaraneni, David Blum, Elizabeth Ludwig, Vaishali Chudasama, Jill Fiedler-Kelly, Marketa Marvanova, Jacquelyn Bainbridge, Luann Phillips
Given the potential consequences of antiepileptic therapy nonadherence, missed-dose scenarios of 12- to 48-hour dose delays (4-hour intervals) for eslicarbazepine acetate monotherapy were evaluated using simulated plasma concentrations of a population pharmacokinetic model (representing 493 subjects). When 1600-mg doses were delayed 12 to <16 or 36 to <44 hours, simulations showed immediate administration of 1600 mg followed by the same dose at the scheduled time maintained plasma concentrations within the target concentration range...
September 7, 2017: Clinical Pharmacology in Drug Development
https://www.readbyqxmd.com/read/28879362/self-assembly-and-rheology-of-dipolar-colloids-in-simple-shear-studied-using-multi-particle-collision-dynamics
#16
Dmitry Zablotsky, Elmars Blums, Hans J Herrmann
Magnetic nanoparticles in a colloidal solution self-assemble in various aligned structures, which has a profound influence on the flow behavior. However, the precise role of the microstructure in the development of the rheological response has not been reliably quantified. We investigate the self-assembly of dipolar colloids in simple shear using hybrid molecular dynamics and multi-particle collision dynamics simulations with explicit coarse-grained hydrodynamics, conduct simulated rheometric studies and apply micromechanical models to produce master curves, showing evidence of the universality of the structural behavior governed by the competition between the bonding (dipolar) and erosive (thermal and/or hydrodynamic) stresses...
September 7, 2017: Soft Matter
https://www.readbyqxmd.com/read/28871668/retina-and-nerve-fiber-layer-thickness-in-eyes-with-thyroid-associated-ophthalmopathy
#17
Sharon Blum Meirovitch, Igal Leibovitch, Anat Kesler, David Varssano, Amir Rosenblatt, Meira Neudorfer
BACKGROUND: Thyroid-associated ophthalmopathy (TAO) is an inflammatory disease that affects the thyroid gland and the eye orbit. Of patients with TAO, 3%-5% have severe sight-threatening disease due to optic neuropathy Optical coherence tomography (OCT), the non-invasive imaging technology that yields high-resolution cross-sectional images of the retina, provides qualitative and quantitative data on the retina. OBJECTIVES: To apply this technique to quantitatively assess retinal nerve fiber layer (RNFL) and macular ring thicknesses in healthy subjects and in patients with TAO to determine their relationship to the severity of the orbital disease...
May 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28868159/the-effects-of-residential-dual-diagnosis-treatment-on-alcohol-abuse
#18
Stephen J Schoenthaler, Kenneth Blum, Lyle Fried, Marlene Oscar-Berman, John Giordano, Edward J Modestino, Rajendra Badgaiyan
This multi-center study of dual diagnosis (DD) programs involved 804 residential patients with co-occurring alcohol and mental health disorders. The Addiction Severity Index was administered at admission and at one, six, and 12 months after discharge. Repeated measures analysis showed the intoxication rate per month stabilized between months six and 12 with 68% still in remission and an 88% mean reduction from baseline (F = 519, p < .005). A comparison between patients with and without weekly relapse produced significant differences in hospitalization (odds ratio 11...
July 2017: Journal of Systems and Integrative Neuroscience
https://www.readbyqxmd.com/read/28859508/an-unexpected-sight-in-the-rearview-mirror
#19
Lawrence D Blum
No abstract text is available yet for this article.
September 1, 2017: American Journal of Psychiatry
https://www.readbyqxmd.com/read/28851224/a-pulse-of-mercury-and-major-ions-in-snowmelt-runoff-from-a-small-arctic-alaska-watershed
#20
Thomas Alexander Douglas, Matthew Sturm, Joel D Blum, Christopher Polashenski, Sveta Stuefer, Christopher Hiemstra, Alexandra Steffen, Simon Filhol, Romain Prevost
Atmospheric mercury (Hg) is deposited to Polar Regions during springtime atmospheric mercury depletion events (AMDEs) that require halogens and snow or ice surfaces. The fate of this Hg during and following snowmelt is largely unknown. We measured Hg, major ions, and stable water isotopes from the snowpack through the entire spring melt runoff period for two years. Our small (2.5 ha) watershed is near Barrow (now Utqiaġvik), Alaska. We measured discharge, made 10,000 snow depth measurements, and collected over 100 snow and meltwater samples for chemical analysis in 2008 and 2009...
August 30, 2017: Environmental Science & Technology
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