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https://www.readbyqxmd.com/read/29145674/esge-esgena-technical-specification-for-process-validation-and-routine-testing-of-endoscope-reprocessing-in-washer-disinfectors-according-to-en-iso-15883-parts-1-4-and-iso-ts-15883-5
#1
Ulrike Beilenhoff, Holger Biering, Reinhard Blum, Jadranka Brljak, Monica Cimbro, Jean-Marc Dumonceau, Cesare Hassan, Michael Jung, Christiane Neumann, Michael Pietsch, Lionel Pineau, Thierry Ponchon, Stanislav Rejchrt, Jean-François Rey, Verona Schmidt, Jayne Tillett, Jeanin van Hooft
1 Prerequisites. The clinical service provider should obtain confirmation from the endoscope washer-disinfector (EWD) manufacturer that all endoscopes intended to be used can be reprocessed in the EWD. 2 Installation qualification. This can be performed by different parties but national guidelines should define who has the responsibilities, taking into account legal requirements. 3 Operational qualification. This should include parametric tests to verify that the EWD is working according to its specifications...
November 16, 2017: Endoscopy
https://www.readbyqxmd.com/read/29139170/single-cell-resolution-of-human-hemato-endothelial-cells-defines-transcriptional-signatures-of-hemogenic-endothelium
#2
Mathew G Angelos, Juan E Abrahante, Robert H Blum, Dan S Kaufman
Endothelial-to-hematopoietic transition (EHT) is an important stage in definitive hematopoietic development. However, the genetic mechanisms underlying human EHT remains poorly characterized. We performed single cell RNA-seq using 55 hemogenic endothelial cells (HE: CD31(+) CD144(+) CD41(-) CD43(-) CD45(-) CD73(-) RUNX1c(+) ), 47 vascular endothelial cells without hematopoietic potential (non-HE: CD31(+) CD144(+) CD41(-) CD43(-) CD45(-) CD73(-) RUNX1c(-) ), and 35 hematopoietic progenitor cells (HP: CD34(+) CD43(+) RUNX1c(+) ) derived from human embryonic stem cells (hESCs)...
November 15, 2017: Stem Cells
https://www.readbyqxmd.com/read/29133183/fragments-generated-upon-extracellular-matrix-remodeling-biological-regulators-and-potential-drugs
#3
REVIEW
Sylvie Ricard-Blum, Sylvain Vallet
The remodeling of the extracellular matrix (ECM) by several protease families releases a number of bioactive fragments, which regulate numerous biological processes such as autophagy, angiogenesis, adipogenesis, fibrosis, tumor growth, metastasis and wound healing. We review here the proteases which generate bioactive ECM fragments, their ECM substrates, the major bioactive ECM fragments, together with their biological properties and their receptors. The translation of ECM fragments into drugs is challenging and would take advantage of an integrative approach to optimize the design of pre-clinical and clinical studies...
November 10, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29133026/levels-of-adhesion-molecules-in-peripheral-blood-correlat-with-stages-of-diabetic-retinopathy-and-may-serve-as-bio-markers-for-microvascular-complications
#4
Arnon Blum, Nina Pastukh, Dorina Socea, Hanin Jabaly
BACKGROUND: Proliferative diabetic retinopathy is a devastating complication of diabetes mellitus, developing within 15 years in 50% of patients with type 1 diabetes mellitus (DM) and in 10% of patients with type 2 DM. The correlation between levels of inflammatory markers in the peripheral blood and retinopathy staging has not been studied yet, and the purpose of this prospective study was to find a possible association between inflammation and staging of diabetic retinopathy. METHODS: A prospective (pilot) study that measured level of adhesion molecules in the peripheral blood of 10 healthy subjects and 30 patients with type 2 diabetes mellitus...
November 10, 2017: Cytokine
https://www.readbyqxmd.com/read/29132512/ultrasound-and-other-innovations-for-fluid-management-in-the-icu
#5
REVIEW
Mark Blum, Paula Ferrada
Ultrasound is a user-dependent tool that can help guide therapy. The use of ultrasound to guide central line placement decreases complication rates. Cardiac ultrasound can help with the diagnosis of cases of hypotension. Lung and pleura ultrasound is a useful adjunct for diagnosis causes of desaturation. Abdominal ultrasound can help in rapid visitation of fluid and intra-abdominal structures.
December 2017: Surgical Clinics of North America
https://www.readbyqxmd.com/read/29132209/carbon-nitrogen-and-mercury-isotope-evidence-for-the-biogeochemical-history-of-mercury-in-hawaiian-marine-bottomfish
#6
Dana Sackett, Jeffrey C Drazen, Brian N Popp, C Anela Choy, Joel D Blum, Marcus W Johnson
The complex biogeochemical cycle of Hg makes identifying primary sources of fish tissue Hg problematic. To identify sources and provide insight into this cycle, we combined carbon (δ13C), nitrogen amino acid (δ15NPhe), and Hg isotope (Δ199Hg, Δ201Hg, δ202Hg) data for six species of Hawaiian marine bottomfish. Results from these isotopic systems identified individuals within species that likely fed from separate food webs. Terrestrial freshwater inputs to coastal sediments were identified as the primary source of tissue Hg in the jack species, Caranx ignobilis, which inhabit shallow marine ecosystems...
November 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29131843/vertigo-and-dizziness-in-adolescents-risk-factors-and-their-population-attributable-risk
#7
Filipp M Filippopulos, Lucia Albers, Andreas Straube, Lucia Gerstl, Bernhard Blum, Thyra Langhagen, Klaus Jahn, Florian Heinen, Rüdiger von Kries, Mirjam N Landgraf
OBJECTIVES: To assess potential risk factors for vertigo and dizziness in adolescents and to evaluate their variability by different vertigo types. The role of possible risk factors for vertigo and dizziness in adolescents and their population relevance needs to be addressed in order to design preventive strategies. STUDY DESIGN: The study population consisted of 1482 school-children between the age of 12 and 19 years, who were instructed to fill out a questionnaire on different vertigo types and related potential risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/29127886/stealing-behavior-and-impulsivity-in-individuals-with-kleptomania-who-have-been-arrested-for-shoplifting
#8
Austin W Blum, Brian L Odlaug, Sarah A Redden, Jon E Grant
OBJECTIVES: Kleptomania is characterized by strong urges to steal and is one of only a few psychiatric disorders defined by illegal behaviors, but the clinical characteristics of individuals with kleptomania who have faced legal consequences due to their behavior are poorly understood. METHOD: From 2001 to 2012, we recruited 107 adult participants with DSM-IV kleptomania. Participants with a history of shoplifting-related arrest (N=82) were compared with those who had no such history (N=25) on demographics, clinical features, and a self-report measure of impulsivity...
October 12, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/29127848/influence-of-titration-schedule-and-maintenance-dose-on-the-tolerability-of-adjunctive-eslicarbazepine-acetate-an-integrated-analysis-of-three-randomized-placebo-controlled-trials
#9
Gregory Krauss, Victor Biton, Jay H Harvey, Christian Elger, Eugen Trinka, Patrício Soares da Silva, Helena Gama, Hailong Cheng, Todd Grinnell, David Blum
OBJECTIVE: To examine the influence of titration schedule and maintenance dose on the incidence and type of treatment-emergent adverse events (TEAEs) associated with adjunctive eslicarbazepine acetate (ESL). METHODS: Data from three randomized, double-blind, placebo-controlled trials were analyzed. Patients with refractory partial-onset seizures were randomized to maintenance doses of ESL 400, 800, or 1200mg QD (dosing was initiated at 400 or 800mg QD) or placebo...
November 4, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29127800/regulation-of-chemicals-in-children-s-products-how-u-s-and-eu-regulation-impacts-small-markets
#10
Maya Negev, Tamar Berman, Shay Reicher, Simona Balan, Anna Soehl, Shula Goulden, Ruti Ardi, Yaniv Shammai, Laura Hadar, Arlene Blum, Miriam L Diamond
Toys and children's products may contain trace metals and organic compounds that are potentially harmful to the health and development of infants and young children. Intergovernmental organizations and individual countries regulate chemicals in consumer products, but a coordinated international approach is lacking. This paper examines the implications of chemical regulation in children's products in large markets for a smaller market, namely Israel. We compared chemical regulations in children's products in the U...
November 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29125712/lipid-metabolism-and-functional-assessment-of-discarded-human-livers-with-steatosis-undergoing-24-hours-normothermic-machine-perfusion
#11
Qiang Liu, Ahmed Nassar, Laura Buccini, Giuseppe Iuppa, Basem Soliman, Daniele Pezzati, Ahmed Hassan, Matthew Blum, William Baldwin, Ana Bennett, Kenneth Chavin, Toshihiro Okamoto, Teresa Diago Uso, John Fung, Kareem Abu-Elmagd, Charles Miller, Cristiano Quintini
Normothermic machine perfusion (NMP) is an emerging technology to preserve liver allografts more effectively than cold storage (CS). However, little is known about the effect of NMP on steatosis, and the markers indicative of hepatic quality during NMP. To address these points we perfused 10 discarded human livers with oxygenated NMP for 24 hours after 4-6 hours of CS. All livers had variable degree of steatosisat at baseline. The perfusate consisted of packed red blood cells and fresh frozen plasma. Perfusate analysis showed an increase in triglyceride levels from the 1st hour (median 127 mg/dL; interquartile range 95-149) to 24th hour of perfusion (203;171-304) (p=0...
November 10, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29122045/field-dependent-measurement-of-gaas-composition-by-atom-probe-tomography
#12
Enrico Di Russo, Ivan Blum, Jonathan Houard, Gérald Da Costa, Didier Blavette, Lorenzo Rigutti
The composition of GaAs measured by laser-assisted atom probe tomography may be inaccurate depending on the experimental conditions. In this work, we assess the role of the DC field and the impinging laser energy on such compositional bias. The DC field is found to have a major influence, while the laser energy has a weaker one within the range of parameters explored. The atomic fraction of Ga may vary from 0.55 at low-field conditions to 0.35 at high field. These results have been interpreted in terms of preferential evaporation of Ga at high field...
November 10, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/29116963/an-objective-method-to-determine-the-electrically-evoked-stapedius-reflex-threshold-during-cochlea-implantation
#13
Bernhard G Weiss, Friederike Söchting, Mattis Bertlich, Martin Busch, Jenny Blum, Friedrich Ihler, Martin Canis
OBJECTIVE: In cochlea implantation, assessment of the electrically evoked stapedius reflex threshold (eSRT) provides information for postoperative adjustment of the speech processor. This is used to prevent undesired overstimulation. To this day, the reflex is visually identified by the surgeon. However, this method may be prone to error due to ventilation-associated situs excursions, blinking, or other distractions. Therefore, the aim of this study was to establish an objective and automatized method to determine the eSRT...
November 7, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/29114598/long-term-survival-and-toxicity-outcomes-of-intensity-modulated-radiation-therapy-for-the-treatment-of-esophageal-cancer-a-large-single-institutional-cohort-study
#14
Anhui Shi, Zhongxing Liao, Pamela K Allen, Linus Ho, Mariela Blum Murphy, Dipen M Maru, Stephen G Swisher, Wayne L Hofstetter, Reza J Mehran, James D Cox, Ritsuko Komaki, Steven H Lin
Purpose: In patients with esophageal cancer (EC), intensity modulated radiation therapy (IMRT) improves dose sparing to the heart and lung, with some evidence showing clinical benefit. Herein, we report our cumulative clinical experience with the use of IMRT for EC. Methods and materials: This is a retrospective analysis of 587 patients with nonmetastatic EC who were treated consecutively with IMRT from January 2004 to June 30, 2013. All patients with stage I-IVA (American Joint Committee on Cancer 2002) received concurrent chemoradiation therapy either preoperatively or definitively...
July 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29113402/patterns-of-relapse-in-patients-with-localized-gastric-adenocarcinoma-who-had-surgery-with-or-without-adjunctive-therapy-costs-and-effectiveness-of-surveillance
#15
Elena Elimova, Rebecca S Slack, Hsiang-Chun Chen, Venkatram Planjery, Hironori Shiozaki, Yusuke Shimodaira, Nick Charalampakis, Quan Lin, Kazuto Harada, Roopma Wadhwa, Jeannelyn S Estrella, Dilsa Mizrak Kaya, Tara Sagebiel, Jeffrey H Lee, Brian Weston, Manoop Bhutani, Mariela Blum Murphy, Aurelio Matamoros, Bruce Minsky, Prajnan Das, Paul F Mansfield, Brian D Badgwell, Jaffer A Ajani
Purpose: After therapy of localized gastric adenocarcinoma (GAC) patients, the costs of surveillance, relapse patterns, and possibility of salvage are unknown. Materials and Methods: We identified 246 patients, who after having a negative peritoneal staging, received therapy (any therapy which included surgery) and were surveyed (every 3-6 months in the first 3 years, then yearly; ∼10 CTs and ∼7 endoscopies per patient). We used the 2016 Medicare dollars reimbursed as the "costs" for surveillance...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29109870/acute-onset-panhypopituitarism-nearly-missed-by-initial-cosyntropin-testing
#16
Claudine A Blum, Daniel Schneeberger, Matthias Lang, Janko Rakic, Marc Philippe Michot, Beat Müller
Introduction: Diagnosis of adrenal crisis and panhypopituitarism in patients with septic shock is difficult but crucial for outcome. Case: A 66-year-old woman with metastasized breast cancer presented to the ED with respiratory insufficiency and septic shock after a 2-day history of the flu. After transfer to the ICU, corticosteroids were started in addition to antibiotics, as the patient was vasopressor-nonresponsive. Diabetes insipidus was diagnosed due to polyuria and treated with 4 mg desmopressin...
2017: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29108314/utility-of-endoscopic-ultrasound-guided-fine-needle-aspiration-of-regional-lymph-nodes-that-are-proximal-to-and-far-from-the-primary-distal-esophageal-carcinoma
#17
Yusuke Shimodaira, Rebecca S Slack, Kazuto Harada, Manoop S Bhutani, Elena Elimova, Gregg A Staerkel, Nour Sneige, Jeremy Erasmus, Hironori Shiozaki, Nikolaos Charalampakis, Venkatram Planjery, Dilsa Mizrak Kaya, Fatemeh G Amlashi, Mariela A Blum, Heath D Skinner, Bruce D Minsky, Dipen M Maru, Wayne L Hofstetter, Stephen G Swisher, Jeannette E Mares, Jane E Rogers, Quan D Lin, William A Ross, Brian Weston, Jeffrey H Lee, Jaffer A Ajani
Implications of assessing the proximal and far para-tracheal or sub-carinal nodes (para-tracheal [PTN] or sub-carinal [SCN]) associated with lower primary esophageal carcinomas (ECs) are unclear. To evaluate the value of endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) for PTN and SCN, we analyzed results by positron emission tomography (PET) avidity, 4 EUS node malignancy features, and EUS-FNA results in all patients with Siewert's I or II EC. Of 133 patients (PTN, n=102; SCN, n=31) with EUS-FNA, 47 (35%) patients had malignant node, leading to treatment modifications...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29104007/perinatal-exposure-to-concentrated-ambient-particulates-results-in-autism-like-behavioral-deficits-in-adult-mice
#18
Jamie S Church, Pamella B Tijerina, Felicity J Emerson, Morgan A Coburn, Jason L Blum, Judith T Zelikoff, Jared J Schwartzer
Exposure to fine ambient particulates (PM2.5) during gestation or neonatally has potent neurotoxic effects. While biological and behavioral data indicate a vulnerability to environmental pollutants across distinct neurodevelopmental windows, the behavioral consequences following exposure across the entire developmental period remain unknown. Moreover, several epidemiological studies support a link between developmental exposure to air pollution and an increased risk of later receiving a diagnosis of autism spectrum disorders (ASD), a neurodevelopmental disorder that persists throughout life...
November 2, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/29103239/elevated-levels-of-mir-122-in-serum-may-contribute-to-improved-endothelial-function-and-lower-oncologic-risk-following-bariatric-surgery
#19
Arnon Blum, Hila Yehuda, Nissim Geron, Ari Meerson
BACKGROUND: Weight loss surgery is the most effective treatment for obesity, and it reduces cardiovascular and cancer risk through poorly understood mechanisms. MicroRNAs (miRNAs) are short RNA molecules that regulate the stability and translation of many mRNAs. We hypothesized that levels of specific circulating miRNAs are altered following surgery and may contribute to lower cancer risk. OBJECTIVES: To investigate the change of miRNA following surgery. METHODS: All patients underwent gastric "sleeve operation"...
October 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29097496/response-to-mek-inhibition-with-trametinib-and-tyrosine-kinase-inhibition-with-imatinib-in-multifocal-histiocytic-sarcoma
#20
Sophie Voruz, Anne Cairoli, Olaia Naveiras, Laurence de Leval, Edoardo Missiaglia, Krisztian Homicsko, Olivier Michielin, Sabine Blum
No abstract text is available yet for this article.
November 2, 2017: Haematologica
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