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https://www.readbyqxmd.com/read/29349498/plasma-metabolites-associated-with-type-2-diabetes-in-a-swedish-population-a-case-control-study-nested-in-a-prospective-cohort
#1
Lin Shi, Carl Brunius, Marko Lehtonen, Seppo Auriola, Ingvar A Bergdahl, Olov Rolandsson, Kati Hanhineva, Rikard Landberg
AIMS/HYPOTHESIS: The aims of the present work were to identify plasma metabolites that predict future type 2 diabetes, to investigate the changes in identified metabolites among individuals who later did or did not develop type 2 diabetes over time, and to assess the extent to which inclusion of predictive metabolites could improve risk prediction. METHODS: We established a nested case-control study within the Swedish prospective population-based Västerbotten Intervention Programme cohort...
January 18, 2018: Diabetologia
https://www.readbyqxmd.com/read/29300151/bacillus-camelliae-sp-nov-isolated-from-pu-er-tea
#2
Lili Niu, Mengjie Xiong, Juan Zhang, Yangquan Xiang, Lei Song, Ziyi Hua, Wenying Li
A novel aerobic, Gram-stain-positive, sporogenous, rod-shaped bacterial strain, 7578-1T, was isolated from ripened Pu'er tea. Based on 16S rRNA gene sequence similarity comparisons, strain 7578-1T was grouped into the genus Bacillus and appeared to be closely related to the type strains Bacillus shackletoniiLMG 18435T (98.4 %), Bacillus acidicolaDSM 14745T (97.6 %), Bacillus paralicheniformis KACC 18426T (97.2 %) and Bacillus ginsengihumi KCTC 13944T (96.7 %). The fatty acid profile containing the major fatty acids, iso-C15 : 0, anteiso-C15 : 0 and anteiso-C17 : 0 supported the allocation of strain 7578-1T to the genus Bacillus...
January 4, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29299847/baekduia-soli-gen-nov-sp-nov-a-novel-bacterium-isolated-from-the-soil-of-baekdu-mountain-and-proposal-of-a-novel-family-name-baekduiaceae-fam-nov
#3
Dong-Shan An, Muhammad Zubair Siddiqi, Kyoung-Ho Kim, Hong-Shan Yu, Wan-Taek Im
A taxonomic study was conducted on BR7-21T, a bacterial strain isolated from the soil of a ginseng field in Baekdu Mountain. Comparative studies of the 16S rRNA gene sequence showed that the isolate was most closely related to Conexibacter woesei DSM 14684T, Solirubrobacter pauli ATCC BAA-492T, Patulibacter minatonensis JCM 12834T, with 93.8%, 92.4%, and 91.5% sequence similarity, respectively; each genus represented a family in the order Solirubrobacterales. Strain BR7-21T was Gram-reaction positive, non-spore forming, aerobic, non-motile, and short rod-shaped...
January 2018: Journal of Microbiology / the Microbiological Society of Korea
https://www.readbyqxmd.com/read/29297846/bacillus-tamaricis-sp-nov-an-alkaliphilic-bacterium-isolated-from-a-tamarix-cone-soil
#4
Yong-Guang Zhang, Xing-Kui Zhou, Jian-Wei Guo, Min Xiao, Hong-Fei Wang, Yun Wang, Khursheda Bobodzhanova, Wen-Jun Li
A Gram-stain-positive, alkaliphilic bacterium, designated EGI 80668T, was isolated from a Tamarix cone soil in Xinjiang, north-west China. Cells were facultatively anaerobic, terminal endospore-forming and motile by means of peritrichous flagella. Colonies were yellowish and the cells showed oxidase-negative and catalase-positive reactions. Strain EGI 80668T grew at pH 8.0-10.0 and with 0-10 % (w/v) NaCl (optimally at pH 9.0 and with 1-2 % NaCl) on marine agar 2216. The predominant menaquinone was MK-7...
January 3, 2018: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29261810/whole-genome-microarray-analysis-of-neural-progenitor-c17-2-cells-during-differentiation-and-validation-of-30-neural-mrna-biomarkers-for-estimation-of-developmental-neurotoxicity
#5
Kristina Attoff, Anda Gliga, Jessica Lundqvist, Ulf Norinder, Anna Forsby
Despite its high relevance, developmental neurotoxicity (DNT) is one of the least studied forms of toxicity. Current guidelines for DNT testing are based on in vivo testing and they require extensive resources. Transcriptomic approaches using relevant in vitro models have been suggested as a useful tool for identifying possible DNT-generating compounds. In this study, we performed whole genome microarray analysis on the murine progenitor cell line C17.2 following 5 and 10 days of differentiation. We identified 30 genes that are strongly associated with neural differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/29248731/pharmacokinetic-profile-of-pbrm-in-rodents-a-first-selective-covalent-inhibitor-of-17%C3%AE-hsd1-for-breast-cancer-and-endometriosis-treatments
#6
René Maltais, Alexandre Trottier, Jenny Roy, Diana Ayan, Nicolas Bertrand, Donald Poirier
The development of a covalent inhibitor of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a promising approach for the treatment of hormone-dependent breast cancer and endometriosis. After reporting the steroid derivative PBRM as a first potent covalent inhibitor of 17β-HSD1 without estrogenic activity, we are now interested in studying its pharmaceutical behavior. The metabolism study in a human liver microsomal preparation showed a gradual transformation of PBRM into PBRM-O, an oxidized ketonic form of PBRM at position C17...
December 14, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29235979/aminipila-butyrica-gen-nov-sp-nov-a-strictly-anaerobic-arginine-decomposing-bacterium-isolated-from-a-methanogenic-reactor-of-cattle-waste
#7
Atsuko Ueki, Kazushi Goto, Nobuo Kaku, Katsuji Ueki
A strictly anaerobic bacterial strain (FH042T) was isolated from a methanogenic reactor treating waste from cattle farms. Cells were stained Gram-positive, straight to gently curved rods with polar flagella. The strain was asaccharolytic. The strain fermented amino acids (l-arginine, l-lysine and l-serine) as growth substrates and produced acetate and butyrate. The optimum temperature for growth was 30 °C and the optimum pH was 6.1-6.8. Oxidase, catalase and nitrate-reducing activities were negative. Hydrogen sulfide was produced...
December 13, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29231155/pedobacter-quisquiliarum-sp-nov-isolated-from-activated-sludge
#8
Bo Zhang, Zhi-Qiang Liu, Yu-Guo Zheng
A Gram-stain-negative, aerobic, rod-shaped, bacterium, C62-2T, was isolated from activated sludge in Fujian Province, China. Phylogenetic analysis of the 16S rRNA gene sequences showed that it was closely related to Pedobacter duraquae WB 2.1-25T (97.92 %), Pedobacter bambusae THG-G118T (97.40 %), Pedobacter cryoconitis A37T (97.37 %) and Pedobacter caeni LMG 22862T (97.3 %). Cells grew aerobically at 20-37 °C (optimum, 30 °C), pH 5.0-8.0 (optimum, pH 7.0) and in the presence of 0-3.0 % (w/v) NaCl...
December 12, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29214367/subtercola-vilae-sp-nov-a-novel-actinobacterium-from-an-extremely-high-altitude-cold-volcano-lake-in-chile
#9
Alvaro S Villalobos, Jutta Wiese, Pablo Aguilar, Cristina Dorador, Johannes F Imhoff
A novel actinobacterium, strain DB165T, was isolated from cold waters of Llullaillaco Volcano Lake (6170 m asl) in Chile. Phylogenetic analysis based on 16S rRNA gene sequences identified strain DB165T as belonging to the genus Subtercola in the family Microbacteriaceae, sharing 97.4% of sequence similarity with Subtercola frigoramans DSM 13057T, 96.7% with Subtercola lobariae DSM 103962T, and 96.1% with Subtercola boreus DSM 13056T. The cells were observed to be Gram-positive, form rods with irregular morphology, and to grow best at 10-15 °C, pH 7 and in the absence of NaCl...
December 6, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29208634/the-synthetic-microneurotrophin-bnn27-affects-retinal-function-in-streptozotocin-induced-diabetic-rats
#10
Ruth Ibán-Arias, Silvia Lisa, Niki Mastrodimou, Despina Kokona, Emmanuil Koulakis, Panagiota Iordanidou, Antonis Kouvarakis, Myrto Fothiadaki, Sofia Papadogkonaki, Aggeliki Sotiriou, Haralambos E Katerinopoulos, Achille Gravanis, Ioannis Charalampopoulos, Kyriaki Thermos
BNN27, a C17-spiroepoxy derivative of DHEA, was shown to have anti-apoptotic properties via mechanisms involving the NGF receptors (TrkA/ p75NTR). In this study we examined the effects of BNN27 on neural/glial cell function, apoptosis and inflammation in the experimental rat streptozotocin (STZ)-model of diabetic retinopathy (DR). The ability of BNN27 to activate the TrkA receptor and regulate p75NTR expression was investigated. BNN27 (2,10,50mg/kg,7days,i.p.) administration four weeks post STZ-injection (Paradigm A) reversed the diabetes-induced glial activation, loss of function of amacrine cells (bNOS/TH expression) and ganglion cell axons via a TrkAR-dependent mechanism...
December 5, 2017: Diabetes
https://www.readbyqxmd.com/read/29189891/coralloluteibacterium-stylophorae-gen-nov-sp-nov-a-new-member-of-the-family-lysobacteraceae-isolated-from-the-reef-building-coral-stylophora-sp
#11
Wen-Ming Chen, Pei-Bei Xie, Sen-Lin Tang, Shih-Yi Sheu
A bacterial strain, designated Sty a-1T, was isolated from a reef-building coral Stylophora sp., collected off coast of Southern Taiwan and characterized using the polyphasic taxonomy approach. Cells of strain Sty a-1T were Gram-staining-negative, aerobic, poly-β-hydroxybutyrate accumulating, motile by means of flagella, non-spore forming, straight rod-shaped and colonies were yellow and circular. Growth occurred at 15-40 °C (optimum, 30-35 °C), at pH 6-10 (optimum, pH 6.5-8) and with 0-7% NaCl (optimum, 2-3%)...
November 30, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/29184975/gracilibacillus-eburneus-sp-nov-a-moderately-halophilic-bacterium-isolated-from-xinjiang-province-china
#12
Hui-Lin Guan, Yun-Jiao Zhang, Xiao-Ju Lu, Man Jia, Zheng-Yun Zhang, Xu-Hong Gao, Yong-Chun Ma, Fei Tian, Shu-Kun Tang
A novel Gram-staining positive, moderately halophilic, endospore-forming, motile, rod-shaped and strictly aerobic strain, designated YIM 93565T, was isolated from a salt lake in Xinjiang province of China and subjected to a polyphasic taxonomic study. Strain YIM 93565T grew in the range of pH 6.0-9.0 (optimum pH 7.0), 10-45 °C (optimum 35-40 °C) and at salinities of 2-24% (w/v) NaCl (optimum 7-10%). Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain YIM 93565T clustered with members of the genera Gracilibacillus and form a clade with Gracilibacillus bigeumensis KCTC 13130T (95...
November 28, 2017: Archives of Microbiology
https://www.readbyqxmd.com/read/29177601/streptomyces-ginkgonis-sp-nov-an-endophyte-from-ginkgo-biloba
#13
Xia Yan, Yanfang Li, Nana Wang, Yue Chen, Li-Li Huang
A novel endophytic actinomycete strain, designated KM-1-2T, was isolated from seeds of Ginkgo biloba at Yangling, China. A polyphasic approach was used to study the taxonomy of strain KM-1-2T and it was found to show a range of phylogenetic and chemotaxonomic properties consistent with those of members of the genus Streptomyces. The diamino acid of the cell wall peptidoglycan was identified as LL-diaminopimelic acid. No diagnostic sugars were detected in whole cell hydrolysates. The predominant menaquinones were identified as MK-9(H6) and MK-9(H8)...
November 24, 2017: Antonie Van Leeuwenhoek
https://www.readbyqxmd.com/read/29169404/a-mechanistic-study-of-toxoplasma-gondii-rop18-inhibiting-differentiation-of-c17-2-neural-stem-cells
#14
Xian Zhang, Rui Su, Zhengyang Cheng, Wanbo Zhu, Yelin Li, Yongzhong Wang, Jian Du, Yihong Cai, Qingli Luo, Jilong Shen, Li Yu
BACKGROUND: Congenital infection of Toxoplasma gondii is an important factor causing birth defects. The neural stem cells (NSCs) are found to be one of the target cells for the parasite during development of the brain. As a key virulence factor of the parasite that hijacks host cellular functions, ROP18 has been demonstrated to mediate the inhibition of host innate and adaptive immune responses through specific binding different host immunity related molecules. However, its pathogenic actions in NSCs remain elusive...
November 23, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29143729/thalassotalea-coralli-sp-nov-isolated-from-the-torch-coral-euphyllia-glabrescens
#15
Der-Shyan Sheu, Shih-Yi Sheu, Pei-Bei Xie, Sen-Lin Tang, Wen-Ming Chen
Strain Eup a-8(T), isolated from a torch coral Euphyllia glabrescens, was characterized using a polyphasic taxonomy approach. Cells of strain Eup a-8(T) were Gram-staining-negative, aerobic, motile by means of a single polar flagellum, poly-β-hydroxybutyrate-containing, rod-shaped and formed white colonies. Optimal growth occurred at 25-30 °C, pH 7-8, and in the presence of 2 % NaCl. Phylogenetic analyses based on 16S rRNA gene sequences showed that strain Eup a-8(T) belonged to the genus Thalassotalea and showed the highest levels of sequence similarity with respect to Thalassotalea ganghwensis JC2041(T) (97...
November 16, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29139349/leucobacter-triazinivorans-sp-nov-a-s-triazine-herbicide-prometryn-degrading-bacterium-isolated-from-sludge
#16
Le-Ni Sun, Dan-Dan Pan, Xiang-Wei Wu, En-Dong Yang, Ri-Mao Hua, Qing X Li
A Gram-stain-positive, rod-shaped, non-motile bacterial strain, designated JW-1(T), was isolated from activated sludge collected from the outlet of an aeration tank in a prometryn-manufacturing plant, located in Binzhou City, Shandong province, PR China. Phylogenetic analysis, based on 16S rRNA gene sequences, indicated that strain JW-1(T) belongs to the genus Leucobacter and its closest neighbours are 'Leucobacter kyeonggiensis' F3-P9 (98.95 % similarity), Leucobacter celer subsp. astrifaciens CBX151(T) (98...
November 15, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29125459/pseudogracilibacillus-endophyticus-sp-nov-a-moderately-thermophilic-and-halophilic-species-isolated-from-plant-root
#17
Jisun Park, Min-Kyeong Kim, Bo-Ram Yun, Ji-Hye Han, Seung Bum Kim
A Gram-stain-positive strain, designated DT7-02(T), was isolated from the surface-sterilized root of Oenotherabiennis (evening primrose) and subjected to taxonomic characterization. Cells of DT7-02(T) were slender rod-shaped, motile by means of flagella, and oxidase- and catalase-positive. The colonies were circular, pinkish-yellow, opaque, glistering and 1-2 mm in diameter. The strain was moderately thermophilic and halophilic, as growth occurred at 20-44 °C (optimum 40 °C), pH 7-10 (optimum pH 8-9) and in the presence of 0-8 % of NaCl (optimum 4 %) in tryptic soy broth...
November 10, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29125456/microbacterium-album-sp-nov-and-microbacterium-deserti-sp-nov-two-halotolerant-actinobacteria-isolated-from-desert-soil
#18
Zi-Wen Yang, Nimaichand Salam, Mohamed Mohany, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Min Xiao, Wael N Hozzein, Wen-Jun Li
Strains SYSU D8007(T) and SYSU D8014(T) were isolated from desert soil collected from Saudi Arabia. The two isolates were Gram-stain-positive, non-motile, aerobic and non-spore-forming. These strains were able to grow at 4-45 °C and in the presence of up to 8 % (w/v) NaCl. Strain SYSU D8007(T) could grow at pH 6.0-10.0, and strain SYSU D8014(T) at pH 5.0-10.0. They shared highest 16S rRNA gene sequence similarities with Microbacterium marinilacus YM11-607(T) and Microbacterium paludicola US15(T). Menaquinones MK-11 and MK-12 were detected as the respiratory quinones...
November 10, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29116035/characterization-of-trichococcus-paludicola-sp-nov-and-trichococcus-alkaliphilus-sp-nov-isolated-from-a-high-elevation-wetland-by-phenotypic-and-genomic-analyses
#19
Yu-Mei Dai, Ling-Li Zhang, Yan Li, Yu-Qian Li, Xiao-Hui Deng, Ting-Ting Wang, Feng Yang, Yong-Qiang Tian, Na Li, Xing-Mei Zhou, Xiao-Feng Liu, Wen-Jun Li
Two psychrotolerant facultative anaerobes, strains B7-2(T) and B5(T), were isolated from the Zoige Wetland on the Qinghai-Tibetan Plateau. The 16S rRNA gene sequences of strains B7-2(T) and B5(T) shared high similarity (>99 %) with those of the type strains of the genus Trichococcus, while their digital DNA-DNA hybridization values with each other (49 %) and with the reference type strains (48-23 %) were lower than 70 %, which suggest that they represent two novel species of the genus Trichococcus...
November 8, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29116034/castellaniella-fermenti-sp-nov-isolated-from-a-fermented-meal
#20
Shih-Yao Lin, Asif Hameed, Yu-Ting Hsieh, Yi-Han Hsu, Wei-An Lai, Chiu-Chung Young
A polyphasic taxonomic approach was used to characterize a presumably novel bacterium, designated strain CC-YTH191(T), isolated from a fermented meal in Taiwan. Cells of strain CC-YTH191(T) were Gram-stain-negative aerobic rods, which grew at 15-40 °C (optimal 25-30 °C), pH 6.0-9.0 (optimal 7.0) and 1-2 % (w/v) NaCl (optimal 1 %). On the basis of 16S rRNA gene sequence analysis, strain CC-YTH191(T) appeared to belong to the genus Castellaniella, and was closely related to Castellaniella hirudinis (96...
November 8, 2017: International Journal of Systematic and Evolutionary Microbiology
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