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Lncrna fibrosis

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https://www.readbyqxmd.com/read/27588491/long-non-coding-rna-pvt1-activates-hepatic-stellate-cells-through-competitively-binding-microrna-152
#1
Jianjian Zheng, Fujun Yu, Peihong Dong, Limei Wu, Yuan Zhang, Yanwei Hu, Lei Zheng
Epithelial-mesenchymal transition (EMT) process is considered as a key event in the activation of hepatic stellate cells (HSCs). Hedgehog (Hh) pathway is known to be required for EMT process. Long non-coding RNAs (lncRNAs) have been reported to be involved in a wide range of biological processes. Plasmacytoma variant translocation 1 (PVT1), a novel lncRNA, is often up-regulated in various human cancers. However, the role of PVT1 in liver fibrosis remains undefined. In this study, PVT1 was increased in fibrotic liver tissues and activated HSCs...
August 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27585228/role-of-lncrna-activated-by-transforming-growth-factor-beta-in-the-progression-of-hepatitis-c-virus-related-liver-fibrosis
#2
Na Fu, Xuemin Niu, Yang Wang, Huijuan Du, Baoyu Wang, Jinghua Du, Ya Li, Rongqi Wang, Yuguo Zhang, Suxian Zhao, Dianxing Sun, Liang Qiao, Yuemin Nan
Long non-coding RNA (LncRNA)-activated by transforming growth factor-beta (LncRNA-ATB) is a key regulator of transforming growth factor-beta (TGF-β) signaling pathway, and is positively correlated with the development of liver cirrhosis and vascular invasion of hepatocellular carcinoma (HCC). However, the role of LncRNA-ATB in hepatitis C virus (HCV)-related liver fibrosis remains largely unknown. In the present study, we confirmed a high expression level of LncRNA-ATB in the liver tissues and plasma samples of patients with HCV-related hepatic fibrosis, and the plasma level of LncRNA-ATB was significantly correlated with liver fibrosis stages...
August 2016: Discovery Medicine
https://www.readbyqxmd.com/read/27506999/mir-489-inhibits-silica-induced-pulmonary-fibrosis-by-targeting-myd88-and-smad3-and-is-negatively-regulated-by-lncrna-chrf
#3
Qiuyun Wu, Lei Han, Weiwen Yan, Xiaoming Ji, Ruhui Han, Jingjin Yang, Jiali Yuan, Chunhui Ni
Silicosis is an incurable occupational disease associated with inflammation, fibroblast proliferation and the accumulation of extracellular matrix in lung tissues. The dysregulation of lncRNAs and miRNAs has been implicated in many complex diseases; however, the current understanding of their roles in fibrotic lung diseases, especially silicosis, remains limited. Our previous microRNA (miRNA, miR) microarray data have indicated decreased expression levels of miR-489 in lung tissues of silica-induced pulmonary fibrosis...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27434588/long-non-coding-rna-bgas-regulates-the-cystic-fibrosis-transmembrane-conductance-regulator
#4
Sheena M Saayman, Amanda Ackley, Jon Burdach, Matthew Clemson, Dieter C Gruenert, Kiyoshi Tachikawa, Pad Chivukula, Marc S Weinberg, Kevin V Morris
Cystic fibrosis (CF) is a life-shortening genetic disease. The root cause of CF is heritable recessive mutations that affect the cystic fibrosis transmembrance conductance regulator (CFTR) gene and the subsequent expression and activity of encoded ion channels at the cell surface. We show that CFTR is regulated transcriptionally by the actions of a novel long noncoding RNA (lncRNA), designated as BGas, that emanates from intron 11 of the CFTR gene and is expressed in the antisense orientation relative to the protein coding sense strand...
August 2016: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/27391349/long-non-coding-rna-h19-antagonism-protects-against-renal-fibrosis
#5
Hong Xie, Jing-Dong Xue, Feng Chao, Yan-Feng Jin, Qiang Fu
Although long non-coding RNAs (lncRNAs) are important players in the initiation and progression of many pathological processes, the role of lncRNAs in renal fibrosis still remains unclear. We showed that lncRNA-H19 expression was significantly up-regulated in TGF-β2-induced HK-2 cell fibrosis and unilateral ureteral obstruction (UUO)-induced renal fibrosis in vivo. H19 knockdown significantly attenuated renal fibrosis in vitro and in vivo. LncRNA-H19, miR-17, and fibronectin constituted to a regulatory network involved in renal fibrosis...
July 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27350269/mecp2-silencing-of-lncrna-h19-controls-hepatic-stellate-cell-proliferation-by-targeting-igf1r
#6
Jing-Jing Yang, Li-Ping Liu, Hui Tao, Wei Hu, Peng Shi, Zi-Yu Deng, Jun Li
Methyl-CpG-binding protein 2 (MeCP2) plays a key role in liver fibrosis. However, the potential mechanism of MeCP2 in liver fibrosis remains unclear. Early reports suggest that LncRNA H19 is important epigenetic regulator with critical roles in cell proliferation, but its role in hepatic fibrosis remains elusive. Sprague-Dawley rats liver fibrosis was generated by 12-weeks treatment with CCl4 intraperitoneal injection. HSC-T6 cells were used in vitro study. The expression levels of MeCP2, H19, IGF1R, α-SMA, and Col1A1 were estimated by Western blotting, qRT-PCR and Immunohistochemistry...
June 1, 2016: Toxicology
https://www.readbyqxmd.com/read/27318893/long-noncoding-rna-h19-controls-dusp5-erk1-2-axis-in-cardiac-fibroblast-proliferation-and-fibrosis
#7
Hui Tao, Wei Cao, Jing-Jing Yang, Kai-Hu Shi, Xiao Zhou, Li-Ping Liu, Jun Li
Down-regulation of DUSP5 has been shown to increase cell proliferation. DUSP5 expression is regulated through epigenetic events involving LncRNA H19 human choriocarcinoma cell line. However, the molecular mechanisms of H19 modulating the DUSP5 expression in cardiac fibrosis remain largely unknown. Here, we identify H19 negatively regulation of DUSP5 gene expression in cardiac fibroblast and fibrosis tissues. In vivo, the expression levels of H19, DUSP5, α-SMA, p-ERK1/2, and ERK1/2 in cardiac fibrosis tissue were estimated by Western blotting, quantitative reverse transcription-polymerase chain reaction and immunohistochemistry...
September 2016: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
https://www.readbyqxmd.com/read/27318030/lncrna-in-the-liver-prospects-for-fundamental-research-and-therapy-by-rna-interference
#8
Elena M Smekalova, Yuri V Kotelevtsev, Dominique Leboeuf, Evgeniya Y Shcherbinina, Anna S Fefilova, Timofei S Zatsepin, Victor Koteliansky
Long non-coding RNAs constitute the most abundant part of the transcribed mammalian genome. lncRNAs affect all essential processes in the living cell including transcription, splicing, translation, replication, shaping of chromatin and post translational modification of proteins. Alterations in lncRNA expression have been linked to a number of diseases; thus, modulation of lncRNA expression holds a huge potential for gene-based therapy. In this review we summarize published data about lncRNAs in the context of hepatic carcinogenesis and liver fibrosis, and the corresponding potential targets for gene therapy...
June 16, 2016: Biochimie
https://www.readbyqxmd.com/read/27189340/whole-transcriptome-analysis-of-uuo-mouse-model-of-renal-fibrosis-reveals-new-molecular-players-in-kidney-diseases
#9
Eleni Arvaniti, Panagiotis Moulos, Athina Vakrakou, Christos Chatziantoniou, Christos Chadjichristos, Panagiotis Kavvadas, Aristidis Charonis, Panagiotis K Politis
Transcriptome analysis by RNA-seq technology allows novel insights into gene expression and regulatory networks in health and disease. To better understand the molecular basis of renal fibrosis, we performed RNA-seq analysis in the Unilateral Ureteric Obstruction (UUO) mouse model. We analysed sham operated, 2- and 8-day post-ligation renal tissues. Thousands of genes with statistical significant changes in their expression were identified and classified into cellular processes and molecular pathways. Many novel protein-coding genes were identified, including critical transcription factors with important regulatory roles in other tissues and diseases...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27129287/expression-signature-of-lncrnas-and-their-potential-roles-in-cardiac-fibrosis-of-post-infarct-mice
#10
Xuefeng Qu, Xiaotong Song, Wei Yuan, You Shu, Yuying Wang, Xuyun Zhao, Ming Gao, Renzhong Lu, Shenjian Luo, Wei Zhao, Yue Zhang, Lihua Sun, Yanjie Lu
The present study aimed to investigate whether long non-coding RNAs (lncRNAs) are involved in cardiac fibrogenesis induced by myocardial infarction (MI). The differentially expressed lncRNAs and mRNAs in peri-infarct region of mice 4 weeks after MI were selected for bioinformatic analysis including gene ontology (GO) enrichment, pathway and network analysis. Left ventricular tissue levels of lncRNAs and mRNAs were compared between MI and sham control mice, using a false discovery rate (FDR) of <5%. Out of 55000 lncRNAs detected, 263 were significantly up-regulated and 282 down-regulated...
July 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27083175/long-non-coding-rna-ensmust00000147869-protects-mesangial-cells-from-proliferation-and-fibrosis-induced-by-diabetic-nephropathy
#11
Min Wang, Di Yao, Suyu Wang, Qin Yan, Weiping Lu
Diabetic nephropathy as the primary cause of end-stage renal disease reveals an increased incidence in patients with kidney disease as the continuous rising of type 2 diabetes. Long non-coding RNAs (lncRNAs) are involved in the development of many diseases including diabetes; however, the role of lncRNAs in diabetic nephropathy is still unclear. In the present study, lncRNA microarray analysis was used to identify abnormally expressed lncRNAs and nearby mRNAs in renal cortical tissues dissected from kidney of db/db and db/m mice...
April 15, 2016: Endocrine
https://www.readbyqxmd.com/read/27007663/long-noncoding-rnas-expressed-in-human-hepatic-stellate-cells-form-networks-with-extracellular-matrix-proteins
#12
Chan Zhou, Samuel R York, Jennifer Y Chen, Joshua V Pondick, Daniel L Motola, Raymond T Chung, Alan C Mullen
BACKGROUND: Hepatic fibrosis is the underlying cause of cirrhosis and liver failure in nearly every form of chronic liver disease, and hepatic stellate cells (HSCs) are the primary cell type responsible for fibrosis. Long noncoding RNAs (lncRNAs) are increasingly recognized as regulators of development and disease; however, little is known about their expression in human HSCs and their function in hepatic fibrosis. METHODS: We performed RNA sequencing and ab initio assembly of RNA transcripts to define the lncRNAs expressed in human HSC myofibroblasts...
2016: Genome Medicine
https://www.readbyqxmd.com/read/26923441/a-novel-long-non-coding-rna-cyp4b1-ps1-001-regulates-proliferation-and-fibrosis-in-diabetic-nephropathy
#13
Min Wang, Suyu Wang, Di Yao, Qin Yan, Weiping Lu
Diabetic nephropathy is an important microvascular complication of diabetes, and the incidence of end-stage renal disease caused by it are rising annually. Long non-coding RNAs (lncRNAs) are widely regarded to associate with the occurrence and development of various diseases; however, the relationship between lncRNAs and diabetic nephropathy remains largely unknown. This work studied the effect of lncRNAs on diabetic nephropathy pathogenesis. LncRNA microarrays were initially used to detect lncRNAs with altered expression in three cases of kidney tissue from db/db mice with diabetic nephropathy...
May 5, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/26919721/long-non-coding-rna-malat-1-is-dispensable-during-pressure-overload-induced-cardiac-remodeling-and-failure-in-mice
#14
Tim Peters, Steffie Hermans-Beijnsberger, Abdelaziz Beqqali, Nicole Bitsch, Shinichi Nakagawa, Kannanganattu V Prasanth, Leon J de Windt, Ralph J van Oort, Stephane Heymans, Blanche Schroen
BACKGROUND: Long non-coding RNAs (lncRNAs) are a class of RNA molecules with diverse regulatory functions during embryonic development, normal life, and disease in higher organisms. However, research on the role of lncRNAs in cardiovascular diseases and in particular heart failure is still in its infancy. The exceptionally well conserved nuclear lncRNA Metastasis associated in lung adenocarcinoma transcript 1 (Malat-1) is a regulator of mRNA splicing and highly expressed in the heart...
2016: PloS One
https://www.readbyqxmd.com/read/26838806/bcl2-is-a-critical-regulator-of-bile-acid-homeostasis-by-dictating-shp-and-lncrna-h19-function
#15
Yuxia Zhang, Chune Liu, Olivier Barbier, Rana Smalling, Hiroyuki Tsuchiya, Sangmin Lee, Don Delker, An Zou, Curt H Hagedorn, Li Wang
Bile acid (BA) metabolism is tightly controlled by nuclear receptor signaling to coordinate regulation of BA synthetic enzymes and transporters. Here we reveal a molecular cascade consisting of the antiapoptotic protein BCL2, nuclear receptor Shp, and long non-coding RNA (lncRNA) H19 to maintain BA homeostasis. Bcl2 was overexpressed in liver of C57BL/6J mice using adenovirus mediated gene delivery for two weeks. Hepatic overexpression of Bcl2 caused drastic accumulation of serum BA and bilirubin levels and dysregulated BA synthetic enzymes and transporters...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26824344/integrated-long-non-coding-rna-analyses-identify-novel-regulators-of-epithelial-mesenchymal-transition-in-the-mouse-model-of-pulmonary-fibrosis
#16
Hao Sun, Junjie Chen, Wenyi Qian, Jiang Kang, Jun Wang, Lei Jiang, Li Qiao, Wei Chen, Jinsong Zhang
Idiopathic pulmonary fibrosis (IPF) is a chronic fatal lung disease characterized by aberrant accumulation of fibroblast population and deposition of extra cellular matrix. Increasing evidence support that epithelial-mesenchymal transition (EMT) of alveolar epithelial cells is a critical process in the pathogenesis of IPF. Although delivery of bleomycin to induce acute lung injury is the most well-studied animal model of pulmonary fibrosis, there is considerable interest to pursue other models to understand the common and/or specific pathological mechanisms...
July 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/26435214/silent-information-regulator-1-sirt1-ameliorates-liver-fibrosis-via-promoting-activated-stellate-cell-apoptosis-and-reversion
#17
Yuting Wu, Xuejiao Liu, Qun Zhou, Cheng Huang, Xiaoming Meng, Fengyun Xu, Jun Li
SIRT1 (silent information regulator 1), a conserved NAD+-dependent histone deacetylase, is closely related with various biological processes. Moreover, the important role of SIRT1 in alcoholic liver disease, nonalcoholic fatty liver and HCC had been widely reported. Recently, a novel role of SIRT1 was uncovered in organ fibrosis diseases. Here, we investigated the inhibitory effect of SIRT1 in liver fibrogenesis. SIRT1 protein was dramatically decreased in CCl4-treated mice livers. Stimulation of LX-2 cells with TGF-β1 also resulted in a significant suppression of SIRT1 protein...
December 1, 2015: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26269497/interaction-of-long-noncoding-rnas-and-micrornas-in-the-pathogenesis-of-idiopathic-pulmonary-fibrosis
#18
Chaoqun Huang, Ye Yang, Lin Liu
Long noncoding RNAs (lncRNAs) are transcribed RNAs with more than 200 nucleotides in length. A growing body of evidence supports the notion that lncRNAs act as competitive endogenous RNAs for microRNAs and play roles in physiological and pathological processes. Several studies have demonstrated the roles of microRNAs in the pathogenesis of idiopathic pulmonary fibrosis (IPF). However, it is unknown whether lncRNAs are involved in IPF. To investigate the roles of lncRNAs in IPF, we determined the interaction of lncRNAs and microRNAs by motif search and manual comparison...
October 2015: Physiological Genomics
https://www.readbyqxmd.com/read/25979571/losartan-reverses-the-down-expression-of-long-noncoding-rna-nr024118-and-cdkn1c-induced-by-angiotensin-ii-in-adult-rat-cardiac-fibroblasts
#19
X Jiang, F Zhang, Q Ning
Angiotensin II (Ang II) plays a pivotal role in the pathogenesis of cardiac fibrosis and long noncoding RNAs (lncRNAs) have been found to be involved in human diseases. The roles of Ang II receptors (AT1 and AT2) have been controversial. Our previous studies revealed that Ang II dynamically down-regulated the expression of lncRNA-NR024118 and Cdkn1c in adult rat cardiac fibroblasts. However, up to now, whether the decrease of lncRNA-NR024118 and Cdkn1c induced by Ang II is mediated by AT1 or AT2 has never been illustrated...
June 2015: Pathologie-biologie
https://www.readbyqxmd.com/read/25827714/the-expression-profiling-and-ontology-analysis-of-noncoding-rnas-in-peritoneal-fibrosis-induced-by-peritoneal-dialysis-fluid
#20
Yanli Liu, Runsheng Guo, Guojun Hao, Jun Xiao, Yi Bao, Jing Zhou, Qinkai Chen, Xin Wei
Increasing amounts of evidence have indicated that noncoding RNAs (ncRNAs) have important regulatory potential in various biological processes. However, the contributions of ncRNAs, especially long noncoding RNAs (lncRNAs), to peritoneal fibrosis remain largely unknown. The aim of this study was to investigate miRNA, lncRNA and mRNA expression profiles and their potential roles in the process of peritoneal fibrosis. Microarray expression profiles of the miRNAs, lncRNAs and mRNAs were determined in normal control peritoneum and in a mouse model of peritoneal dialysis fluid (PDF)-induced fibrotic peritoneum...
June 15, 2015: Gene
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