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https://www.readbyqxmd.com/read/29344674/long-non-coding-rna-h1-promotes-cell-proliferation-and-invasion-by-acting-as-a-cerna-of-mir%C3%A2-138-and-releasing-ezh2-in-oral-squamous-cell-carcinoma
#1
Yonglong Hong, Haitao He, Wen Sui, Jingge Zhang, Shenfu Zhang, Dajiang Yang
Long non-coding RNAs (lncRNAs) have been shown to play pivotal roles in various types of human cancer, including oral squamous cell carcinoma (OSCC). However, the potential mechanisms of action of lncRNAs in OSCC remain to be fully elucidated. The aim of the present study was to further explore the potential mechanisms of action of lncRNAs in OSCC. We first analyzed Gene Expression Omnibus (GEO) datasets to investigate aberrantly expressed lncRNAs which may be involved in the development of OSCC. Reverse transcription‑quantitative PCR (RT‑qPCR) was performed to analyze the expression levels of lncRNA H19...
January 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29339211/long-non-coding-rna-xist-promotes-tgf-%C3%AE-induced-epithelial-mesenchymal-transition-by-regulating-mir-367-141-zeb2-axis-in-non-small-cell-lung-cancer
#2
Chang Li, Liang Wan, Zeyi Liu, Guangquan Xu, Shengjie Wang, Zhiyue Su, Yingxi Zhang, Cuijuan Zhang, Xia Liu, Zhe Lei, Hong-Tao Zhang
Growing evidence shows that lncRNA XIST functions as an oncogene accelerating tumor progression. Transforming growth factor β (TGF-β)-induced epithelial-mesenchymal transition (EMT) plays a key role in tumor metastasis. However, it is still unclear whether lncRNA XIST is implicated in TGF-β-induced EMT and influences cell invasion and metastasis in non-small-cell lung cancer (NSCLC). Here, we observed increased expression of lncRNA XIST and ZEB2 mRNA in metastatic NSCLC tissues. Knockdown of lncRNA XIST inhibited ZEB2 expression, and repressed TGF-β-induced EMT and NSCLC cell migration and invasion...
January 12, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29331759/astragaloside-iv-inhibits-cell-migration-and-viability-of-hepatocellular-carcinoma-cells-via-suppressing-long-noncoding-rna-atb
#3
Yaling Li, Yun Ye, Hongyan Chen
Astragaloside IV (AS-IV), the major active component of Astragalus membranaceus, has shown attractive anticancer effects in certain cancers. However, the roles and action mechanisms of AS-IV in hepatocellular carcinoma (HCC) are largely unclear. Long noncoding RNAs (lncRNAs) are recently revealed to have crucial roles in HCC initiation and progression, but whether lncRNAs participate in the anticancer roles of AS-IV are unknown. In this study, we demonstrated that AS-IV significantly downregulated lncRNA-ATB expression in a dose- and time-dependent manner in HCC cells...
January 10, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29329034/long-non-coding-rna-ccat2-promotes-cholangiocarcinoma-cells-migration-and-invasion-by-induction-of-epithelial-to-mesenchymal-transition
#4
Yi Xu, Yue Yao, Wei Qin, Xiangyu Zhong, Xingming Jiang, Yunfu Cui
Cholangiocarcinoma (CCA) is one of the most aggressive malignancies in humans. Emerging evidence has indicated that abnormally expressed long non-coding RNAs (lncRNAs) could conduce to tumorigenesis and progression. Specifically, colon cancer-associated transcript 2 (CCAT2) has been reported to be overexpressed in several carcinomas. However, its clinical significance and functional roles in CCA is still unknown. qRT-PCR experiments were conducted to assess the CCAT2 expression in CCA tissue samples and cell lines...
January 9, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29328404/chronic-oxymatrine-treatment-induces-resistance-and-epithelial%C3%A2-mesenchymal-transition-through-targeting-the-long-non-coding-rna-malat1-in-colorectal-cancer-cells
#5
Yibai Xiong, Jun Wang, Huirong Zhu, Lingshuang Liu, Yi Jiang
A major reason for colorectal cancer (CRC) chemoresistance is the enhanced migration and invasion of cancer cells, such as the cell acquisition of epithelial-mesenchymal transition (EMT). Long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been considered as a pro-oncogene in multiple cancers. However, the precise functional mechanism of lncRNA MALAT1 in chemoresistance and EMT is not well known. In the present study, we focused on the effect of oxymatrine on CRC cells and further investigated the role of MALAT1 in oxymatrine-induced resistance and EMT process...
January 10, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29328401/long-non-coding-rna-meg3-functions-as-a-tumour-suppressor-and-has-prognostic-predictive-value-in-human-pancreatic-cancer
#6
Ling Ma, Feng Wang, Chong Du, Zhengkui Zhang, Huahu Guo, Xuehai Xie, Hongqiao Gao, Yan Zhuang, Marko Kornmann, Hong Gao, Xiaodong Tian, Yinmo Yang
Long non-coding RNA (lncRNA) MEG3 has been demonstrated to be a tumour suppressor in many malignancies. However, the functional role of MEG3 in pancreatic cancer (PC) is unclear. In this study, the expression pattern of MEG3 was evaluated in 25 samples of microdissected PC tissues and 8 PC cell lines and was compared to the expression in adjacent non‑cancerous tissues and a human pancreatic normal epithelial cell line. Loss of MEG3 expression was observed in both the cancerous tissues and cancer cell lines...
January 2, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29325547/paracrine-and-epigenetic-control-of-caf-induced-metastasis-the-role-of-hotair-stimulated-by-tgf-%C3%A3-1-secretion
#7
Yu Ren, Huan-Huan Jia, Yi-Qi Xu, Xuan Zhou, Xiao-Hui Zhao, Yun-Fei Wang, Xin Song, Zhi-Yan Zhu, Ting Sun, Yan Dou, Wei-Ping Tian, Xiu-Lan Zhao, Chun-Sheng Kang, Mei Mei
BACKGROUND: The communication between carcinoma associated fibroblasts (CAFs) and cancer cells facilitate tumor metastasis. In this study, we further underlying the epigenetic mechanisms of CAFs feed the cancer cells and the molecular mediators involved in these processes. METHODS: MCF-7 and MDA-MB-231 cells were treated with CAFs culture conditioned medium, respectively. Cytokine antibody array, enzyme-linked immunosorbent assay, western blotting and immunofluorescence were used to identify the key chemokines...
January 11, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29311643/lncrna-nef-antagonized-epithelial-to-mesenchymal-transition-and-cancer-metastasis-via-cis-regulating-foxa2-and-inactivating-wnt-%C3%AE-catenin-signaling
#8
Wei-Cheng Liang, Jia-Lin Ren, Cheuk-Wa Wong, Sun-On Chan, Mary Miu-Yee Waye, Wei-Ming Fu, Jin-Fang Zhang
Emerging evidence indicates that the long noncoding RNAs extensively participate in cancer progression. Nevertheless, the molecular pathogenesis of how these lncRNAs regulate tumorigenesis has not been fully elucidated especially in hepatocellular carcinoma (HCC). Here, we sought to define the role of a novel lncRNA named lncRNA-NEF in modulating epithelial to mesenchymal transition (EMT) in HCC. It was found that the lncRNA-NEF was transcriptionally activated by EMT suppressor FOXA2 and frequently downregulated in HCC cell lines as well as clinical specimens...
January 9, 2018: Oncogene
https://www.readbyqxmd.com/read/29310682/upregulation-of-the-long-non-coding-rna-afap1-as1-affects-the-proliferation-invasion-and-survival-of-tongue-squamous-cell-carcinoma-via-the-wnt-%C3%AE-catenin-signaling-pathway
#9
Ze-You Wang, Min Hu, Min-Hui Dai, Jing Xiong, Shuai Zhang, Han-Jiang Wu, Shan-Shan Zhang, Zhao-Jian Gong
BACKGROUND: Long non-coding RNA (lncRNA) actin filament associated protein 1 antisense RNA1 (AFAP1-AS1) is oriented in an antisense direction to the protein-coding gene AFAP1 in the opposite strand. Previous studies showed that lncRNA AFAP1-AS1 was upregulated and acted as an oncogene in a variety of tumors. However, the expression and biological functions of lncRNA AFAP1-AS1 in tongue squamous cell carcinoma (TSCC) are still unknown. METHODS: The expression level of AFAP1-AS1 was measured in 103 pairs of human TSCC tissues and corresponding adjacent normal tongue mucous tissues...
January 8, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29295626/lncrna-fundc2p4-down-regulation-promotes-epithelial-mesenchymal-transition-by-reducing-e-cadherin-expression-in-residual-hepatocellular-carcinoma-after-insufficient-radiofrequency-ablation
#10
Zeng Jiangzheng, Xinrui Cai, Xinbao Hao, Fen Huang, Zhihui He, Huamao Sun, Yanda Lu, Junhua Lei, Zeng Wangyuan, Liu Yu, Rongcheng Luo
PURPOSE: HCC after insufficient radiofrequency ablation (RFA) could induce epithelial-mesenchymal transition (EMT) in residual tumors, resulting in rapid and aggressive recurrence. However the role of EMT related Long noncoding RNAs (lncRNAs) in residual tumor progression remains unclear. METHODS: Insufficient RFA was simulated in vitro by heating Huh7 cells in water bath at 47°C, named as Huh7-H. Cell invasion, migration assays and wound healing assay were conducted for functional analysis...
January 2, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29286919/knockdown-of-lncrna-ghet1-suppresses-cell-proliferation-invasion-and-lats1-yap-pathway-in-non-small-cell-lung-cancer
#11
Zhen-Biao Guan, Yu-Shu Cao, Yi Li, Wan-Ning Tong, An-Shan Zhuo
BACKGROUND: The aim in this study was to explore the role of long non-coding RNA GHET1 in development of non small cell lung cancer (NSCLC). METHODS: LncRNA GHET1 expression levels were analyzed by qRT-PCR in tumor tissues and adjacent normal tissues in NSCLC. Measuring the cell proliferation and invasion abilities by CCK8, cell colony formation and transwell invasion assays. Relative protein expression was analyzed by western blot assays. RESULTS: Expression of lncRNA GHET1 was notably higher in NSCLC tissues compared with adjacent normal tissues by using qRT-PCR analyses...
December 22, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29278853/lncrna-hif1a-as2-positively-affects-the-progression-and-emt-formation-of-colorectal-cancer-through-regulating-mir-129-5p-and-dnmt3a
#12
Jinguan Lin, Zhaohui Shi, Zhiyuan Yu, Zhe He
LncRNAs were a group of RNAs, which can be a regulator or master in biological activities of cancer cells. HIF1A-AS2 belongs to this group, and it has been verified to be able to affect cell activities in several kinds of cancers. In this study, we tried to study the functions of HIF1A-AS2 exerted in colorectal cancer. In order to clearly know about the expression of HIF1A-AS2, miR-129-5p and DNMT3A in CRC tissues and cells, we employed qRT-PCR. The relevance among those three genes was examined by the use of Pearson correlation analysis...
December 23, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29258558/hepatitis-b-virus-x-protein-induces-epithelial-mesenchymal-transition-of-hepatocellular-carcinoma-cells-by-regulating-long-non-coding-rna
#13
Yinji Jin, Di Wu, Weiwei Yang, Mingjiao Weng, Yafei Li, Xuefei Wang, Xiao Zhang, Xiaoming Jin, Tianzhen Wang
BACKGROUND: It has been widely accepted that hepatitis B virus X protein (HBx) plays an important role in hepatocellular carcinoma (HCC). This study aimed to explore the function of long non-coding RNAs (lncRNAs) in the epithelial-mesenchymal transition (EMT) induced by HBx. METHODS: The association between HBx and EMT markers was detected using immunohistochemistry in HCC tissues. The effect of HBx on HCC EMT was assessed through morphological analysis, transwell assay, metastatic in vivo study and detection of EMT markers...
December 19, 2017: Virology Journal
https://www.readbyqxmd.com/read/29246789/lncrna-crnde-promotes-osteosarcoma-cell-proliferation-invasion-and-migration-by-regulating-notch1-signaling-and-epithelial-mesenchymal-transition
#14
Zheng Li, Yonghua Tang, Wujun Xing, Wei Dong, Zhichou Wang
Osteosarcoma is the most common bone malignancy in adolescence. Recently, the long non-coding RNAs (lncRNAs) were reported to play important roles in osteosarcoma progression. The present study examined the potential role of the lncRNA, Colorectal Neoplasia Differentially Expressed (CRNDE) and molecular mechanisms underlying osteosarcoma progression. In the present study, we identified that CRNDE was up-regulated in osteosarcoma tissues and cell lines, and CRNDE expression level was significantly higher in osteosarcoma tissues from patients with advanced stage and metastasis...
December 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29239819/lncrna-hoxd-as1-promotes-epithelial-ovarian-cancer-cells-proliferation-and-invasion-by-targeting-mir-133a-3p-and-activating-wnt-%C3%AE-catenin-signaling-pathway
#15
Ying Zhang, Yanbing Dun, Shumin Zhou, Xiang-Hua Huang
BACKGROUND: Long non-coding RNA (lncRNA) HOXD cluster antisense RNA 1 (HOXD-AS1) functions as a crucial regulator in the progression and development of tumors. The aim of this study is to unravel the underlying mechanisms of HOXD-AS1 on epithelial ovarian cancer (EOC). METHODS: 43 paired EOC tissues and adjacent non-tumor tissues were collected postoperatively from patients. QRT-PCR was used to explore HOXD-AS1 expression in both EOC tissues and cell lines. Cell proliferation and invasion were monitored by MTT assay and transwell invasion assay...
November 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29228709/targeting-lncrna-hotair-suppresses-cancer-stemness-and-metastasis-in-oral-carcinomas-stem-cells-through-modulation-of-emt
#16
Ming-Yi Lu, Yi-Wen Liao, Pei-Yin Chen, Pei-Ling Hsieh, Chih-Yuan Fang, Chia-Yu Wu, Ming-Liang Yen, Bou-Yue Peng, Dayen Peter Wang, Hsin-Chung Cheng, Ching-Zong Wu, Yung-Hsun Shih, Duen-Jeng Wang, Cheng-Chia Yu, Lo-Lin Tsai
Increasing evidence indicates that long non-coding RNAs (lncRNAs) regulate diverse cellular processes, such as cell growth, apoptosis and tumorigenesis. However, the functional roles of lncRNAs and mechanistic analysis of their interplays with oncogenic pathways in oral cancer remain largely unknown. In the current study, we examined the significance of lncRNA HOTAIR (HOX transcript antisense RNA) in tumor progression of oral squamous cell carcinomas (OSCC). We found the expression of HOTAIR was upregulated in tumor tissues, especially in the metastatic samples...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29219208/lncrna-h19-promotes-epithelial-mesenchymal-transition-emt-by-targeting-mir-484-in-human-lung-cancer-cells
#17
Qianqian Zhang, Xiaoliang Li, Xiao Li, Xiaosu Li, Zhuochang Chen
BACKGROUND: Recently, the long non-coding RNA (lncRNA) H19 has been identified as an oncogenic gene in multiple cancer types. However, the molecular basis for this observation has not been characterized in lung cancer, especially during epithelial mesenchymal transition (EMT) progression. METHODS: Cell viability, migration, invasion, and apoptosis were measured using trypan blue exclusion assay, Transwell migration/invasion assay, andflow cytometry, respectively...
December 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29217194/long-noncoding-rna-snhg15-promotes-human-breast-cancer-proliferation-migration-and-invasion-by-sponging-mir-211-3p
#18
Qingli Kong, Min Qiu
Long non-coding RNAs (lncRNA) have been demonstrated to act as essential regulators in the development and progression of breast cancer. In our study, we found that long noncoding RNA SNHG15 was highly expressed in breast cancer tissues and cell lines. And the expression of SNHG15 was correlated with TNM stage, lymphnode metastasis and survival in breast cancer patients. SNHG15 knockdown significantly inhibited the proliferation and induced apoptosis in breast cancer cells in vitro and in vivo. Besides, SNHG15 downregulation suppressed cell migration and invasion in MCF-7 and BT-20 cells, and inhibited epithelial-mesenchymal transition (EMT)...
December 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29216625/missing-links-in-epithelial-mesenchymal-transition-long-non-coding-rnas-enter-the-arena
#19
Lei Wang, Fan Yang, Lin-Tao Jia, An-Gang Yang
Cancer metastasis occurs through a series of sequential steps, which involves dissemination of tumor cells from a primary site and colonization in distant tissues. To promote the invasion-metastasis cascade, carcinoma cells usually initiate a cell-biological program called epithelial-mesenchymal transition (EMT), which is orchestrated by a set of master regulators, including TGF-β, Snail, ZEB and Twist families. The biological activities of these molecules are tightly regulated by a variety of cell-intrinsic pathways as well as extracellular cues...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29215719/lncrna-snhg1-negatively-regulates-mir-145a-5p-to-enhance-nuak1-expression-and-promote-cancer-cell-metastasis-and-invasion-in-nasopharyngeal-carcinoma
#20
Leqiu Wang, Xiufeng Ma, Lei Yan, Tianxiu Wang, Jingai Wen, Guangxi Mi
Intention: How lncRNA SNHG1 influences the aggressiveness of nasopharyngeal carcinoma cells as well as the underlying mechanism was studied. METHODS: The lncRNA differences were analyzed by GSE12452 gene microarray. The expression of SNHG1, MiR-145-5p and NUAK1 was identified by qRT-PCR and western blot. Transfection was conducted to construct nasopharyngeal carcinoma cells with different expressions of SNHG1 and miR-145-5p. Dual-luciferase reporter assay was performed to explore the relationship between miR-145-5p and NUAK1...
December 7, 2017: Journal of Cellular Physiology
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