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Lncrna emt

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https://www.readbyqxmd.com/read/28925486/long-non-coding-rna-foxd2-as1-functions-as-a-tumor-promoter-in-colorectal-cancer-by-regulating-emt-and-notch-signaling-pathway
#1
X Yang, B Duan, X Zhou
OBJECTIVE: A growing number of long noncoding RNAs (lncRNAs) are emerging as new modulators in cancer origination and progression. However, the functions and molecular mechanisms of lncRNAs to colorectal cancer (CRC) are still largely unknown. The aim of this study was to investigate the function and role of lncRNA FOXD2-AS1 (FOXD2-AS1) in human CRC. PATIENTS AND METHODS: The expression of FOXD2-AS1 was investigated using Real-time reverse transcription-polymerase chain reaction (qRT-PCR) in 45 CRC specimens and matched adjacent normal tissues and CRC cell lines...
August 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28921383/lncrna-ccat1-promotes-migration-invasion-and-emt-in-intrahepatic-cholangiocarcinoma-through-suppressing-mir-152
#2
Shouhua Zhang, Juhua Xiao, Yong Chai, Yun Yan Du, Zhiqiang Liu, Kai Huang, Xin Zhou, Wei Zhou
BACKGROUND: Increasing evidence has suggested that lncRNA CCAT1 is upregulated and functions as a potential tumor promoter in many cancers. However, the potential biological roles and regulatory mechanisms of CCAT1 in intrahepatic cholangiocarcinoma (ICC) remain unclear. METHODS: We used real-time PCR to measure CCAT1 expression in ICC tissues and the adjacent normal tissues. The statistical analyses were applied to evaluate the prognostic value and associations of CCAT1 expression with clinical parameters...
September 18, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28902349/tug1-promotes-osteosarcoma-tumorigenesis-by-upregulating-ezh2-expression-via-mir-144-3p
#3
Jiaqing Cao, Xinyou Han, Xin Qi, Xiangyun Jin, Xiaolin Li
lncRNA-TUG1 (Taurine upregulated 1) is up-regulated and highly correlated with poor prognosis and disease status in osteosarcoma. TUG1 knockdown inhibits osteosarcoma cell proliferation, migration and invasion, and promotes apoptosis. However, its mechanism of action has not been well addressed. Growing evidence documented that lncRNA works as competing endogenous (ce)RNAs to modulate the expression and biological functions of miRNA. As a putative combining target of TUG1, miR-144-3p has been associated with the progress of osteosarcoma...
August 30, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28900284/mir-503-modulates-epithelial-mesenchymal-transition-in-silica-induced-pulmonary-fibrosis-by-targeting-pi3k-p85-and-is-sponged-by-lncrna-malat1
#4
Weiwen Yan, Qiuyun Wu, Wenxi Yao, Yan Li, Yi Liu, Jiali Yuan, Ruhui Han, Jingjin Yang, Xiaoming Ji, Chunhui Ni
Silicosis is a kind of chronic, progressive and incurable lung fibrotic diseases with largely unknown and complex pathogenesis and molecular mechanisms. Mounting evidence suggests that microRNAs (miRNAs, miRs) are involved in the pathogenesis of silicosis. Our previous study based on miRNA microarray had shown that the expression levels of miR-503 were down-regulated in mouse lung tissues of silica-induced pulmonary fibrosis. Here, we validated the decreased expression of miR-503 in the fibrotic mouse lung tissues, human bronchial epithelial cells (HBE) and human lung adenocarcinoma A549 cells which were exposed to silica...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28886531/long-non-coding-rna-hottip-promotes-hypoxia-induced-epithelial-mesenchymal-transition-of-malignant-glioma-by-regulating-the-mir-101-zeb1-axis
#5
Shanyi Zhang, Weiwei Wang, Guoxin Liu, Shule Xie, Qunxing Li, Yingru Li, Zhaoyu Lin
Hypoxia is a universal characteristic of solid tumor and involving cancer metastasis via epithelial-mesenchymal transition (EMT). Long non-coding RNAs (lncRNAs) are known to regulate carcinogenesis and metastasis of various cancers. The aim of this study was to identify the function role of lncRNAs in the hypoxia-induced EMT of malignant glioma. We used U87 and U251 cell lines were treated under hypoxia to induce EMT, then lncRNA microarray analyse was performed between U87-hypoxia and parental cell line. The relative expression of lncRNA and HIF-1α were detected by qRT-PCR between glioma tissues without metastasis and that with metastasis...
September 5, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28884871/lncrna-atb-an-indispensable-cancer-related-long-noncoding-rna
#6
REVIEW
Jinglin Li, Zhenglong Li, Wangyang Zheng, Xinheng Li, Zhidong Wang, Yunfu Cui, Xingming Jiang
OBJECTIVES: Long non-coding RNAs (lncRNAs) are a group of non-protein-coding RNAs that are greater than 200 nucleotides in length. Increasing evidence indicates that lncRNAs, which may serve as either oncogenes or tumour suppressor genes, play a vital role in the pathophysiology of human diseases, especially in tumourigenesis and progression. Deregulation of lncRNAs impacts different cellular processes, such as proliferation, dedifferentiation, migration, invasion and anti-apoptosis. The aim of this review was to explore the molecular mechanism and clinical significance of long non-coding RNA-activated by transforming growth factor β (lncRNA-ATB) in various types of cancers...
September 8, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/28882595/upregulation-of-sox2-activated-lncrna-pvt1-expression-promotes-breast-cancer-cell-growth-and-invasion
#7
Yan Wang, Jun Zhou, Zhaoxin Wang, Peishun Wang, Shuqin Li
Increasing evidences indicated that Long noncoding RNAs (lncRNAs) played pivotal roles during tumorigenesis in multiple types of cancers, including breast cancer. This study aimed to investigate the role and function of long noncoding RNA PVT1 in the progression of breast cancer and explore the transcription factor which contributes to the regulation of PVT1 in breast cancer. Our results indicated that the expression of PVT1 was significantly upregulated in breast cancer tissues, compared with adjacent normal tissues (ANTs)...
September 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28872613/roles-of-long-noncoding-rnas-in-recurrence-and-metastasis-of-radiotherapy-resistant-cancer-stem-cells
#8
REVIEW
Hsiang-Cheng Chi, Chung-Ying Tsai, Ming-Ming Tsai, Chau-Ting Yeh, Kwang-Huei Lin
Radiotherapy is a well-established therapeutic regimen applied to treat at least half of all cancer patients worldwide. Radioresistance of cancers or failure to treat certain tumor types with radiation is associated with enhanced local invasion, metastasis and poor prognosis. Elucidation of the biological characteristics underlying radioresistance is therefore critical to ensure the development of effective strategies to resolve this issue, which remains an urgent medical problem. Cancer stem cells (CSCs) comprise a small population of tumor cells that constitute the origin of most cancer cell types...
September 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28866868/the-lncrna-hnf1a-as1-is-a-negative-prognostic-factor-and-promotes-tumorigenesis-in-osteosarcoma
#9
Lijun Cai, Jinhan Lv, Yinquan Zhang, Junhong Li, Yinong Wang, Huilin Yang
Recent studies have revealed that long noncoding RNA HNF1A-antisense 1 (HNF1A-AS1) plays an important role in the development of several human malignancy entities. However, the expression and function of HNF1A-AS1 in the carcinogenesis and development of osteosarcoma remains unknown. In this study, we detected the HNF1A-AS1 levels in human osteosarcoma tissues and cell lines by quantitative real-time polymerase chain reaction (qRT-PCR), and investigated its role in osteosarcoma by using in vitro assays. Our study showed that HNF1A-AS1 expression was significantly up-regulated in human osteosarcoma tissues and cell lines compared with their normal counterparts, and its expression level was positively correlated with the distance metastasis (P = 0...
September 2, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28858731/lncrna-fezf1-as1-enhances-epithelial-mesenchymal-transition-emt-through-suppressing-e-cadherin-and-regulating-wnt-pathway-in-non-small-cell-lung-cancer-nsclc
#10
Rong He, Fei Hu Zhang, Ning Shen
OBJECTIVE: Recent discoveries verify that long non-coding RNAs (lncRNAs) are important functional regulators involved in non-small cell lung cancer (NSCLC) progression. However, long non-coding RNA FEZF1-AS1 was not been investigated in NSCLC so for. METHODS: We applied the quantitative real time polymerase chain reaction (qRT-PCR) assays to detect the expression of lncRNA FEZF1-AS1 in NSCLC tissues and adjacent normal tissues. Cell proliferation and invasion capacities were evaluated by MTT, colony formation, and cell invasion assays...
August 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28854421/long-noncoding-rna-fal1-promotes-cell-proliferation-invasion-and-epithelial-mesenchymal-transition-through-the-pten-akt-signaling-axis-in-non-small-cell-lung-cancer
#11
Chunfeng Pan, Guoliang Yao, Bin Liu, Teng Ma, Yang Xia, Ke Wei, Jun Wang, Jin Xu, Liang Chen, Yijiang Chen
BACKGROUND/AIMS: Recently, long non-coding RNAs (lncRNAs) have been found to have many biological effects in different cancer stages. Several studies have revealed that focally amplified lncRNA on chromosome 1 (FAL1) regulates cancer progression via p21. However, the expression and mechanism of FAL1 in non-small cell lung cancer (NSCLC) still remain unclear. METHODS: We detected the FAL1 level in NSCLC tissues and in established cell lines using quantitative real-time PCR and evaluated the clinical significance...
August 31, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28839203/fine-particulate-matter-2-5-exerted-its-toxicological-effect-by-regulating-a-new-layer-long-non-coding-rna
#12
Qiansheng Huang, Yulang Chi, Junjun Deng, Yiyao Liu, Yanyang Lu, Jinsheng Chen, Sijun Dong
Fine particulate matter (PM2.5) exposure, especially to its organic components, induces adverse health effects on the respiratory system. However, the molecular mechanisms have still not been fully elucidated. Long non-coding RNA (lncRNA) is involved in various physio-pathological processes. In this study, the roles of lncRNA were investigated to reveal the toxicology of PM2.5. Organic extracts of PM2.5 from Nanjing and Shanghai cities were adopted to treat human bronchial epithelial cell lines (BEAS-2B and A549)...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28837144/long-noncoding-rna-xist-expedites-metastasis-and-modulates-epithelial-mesenchymal-transition-in-colorectal-cancer
#13
Dong-Liang Chen, Le-Zong Chen, Yun-Xin Lu, Dong-Sheng Zhang, Zhao-Lei Zeng, Zhi-Zhong Pan, Peng Huang, Feng-Hua Wang, Yu-Hong Li, Huai-Qiang Ju, Rui-Hua Xu
Tumor progression and metastasis is the main cause of death in colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) are critical regulators in various diseases including human cancer. In this study, we found that lncRNA XIST was overexpressed in CRC cell lines and tissues. High expression of lncRNA XIST was associated with adverse overall survival in CRC patients. Knockdown of lncRNA XIST remarkably inhibited CRC cell proliferation, invasion, epithelial-mesenchymal transition (EMT) and CRC stem cell formation in vitro as well as tumor growth and metastasis in vivo...
August 24, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28825698/a-regulated-pnuts-mrna-to-lncrna-splice-switch-mediates-emt-and-tumour-progression
#14
Simon Grelet, Laura A Link, Breege Howley, Clémence Obellianne, Viswanathan Palanisamy, Vamsi K Gangaraju, J Alan Diehl, Philip H Howe
The contribution of lncRNAs to tumour progression and the regulatory mechanisms driving their expression are areas of intense investigation. Here, we characterize the binding of heterogeneous nuclear ribonucleoprotein E1 (hnRNP E1) to a nucleic acid structural element located in exon 12 of PNUTS (also known as PPP1R10) pre-RNA that regulates its alternative splicing. HnRNP E1 release from this structural element, following its silencing, nucleocytoplasmic translocation or in response to TGFβ, allows alternative splicing and generates a non-coding isoform of PNUTS...
September 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28819095/non-coding-rnas-participate-in-the-regulatory-network-of-cldn4-via-cerna-mediated-mirna-evasion
#15
Yong-Xi Song, Jing-Xu Sun, Jun-Hua Zhao, Yu-Chong Yang, Jin-Xin Shi, Zhong-Hua Wu, Xiao-Wan Chen, Peng Gao, Zhi-Feng Miao, Zhen-Ning Wang
Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into "networks" based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p...
August 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28813705/the-lncrna-tug1-ezh2-axis-promotes-pancreatic-cancer-cell-proliferation-migration-and-emt-phenotype-formation-through-sponging-mir-382
#16
Liang Zhao, Hongwei Sun, Hongru Kong, Zongjing Chen, Bicheng Chen, Mengtao Zhou
BACKGROUND/AIMS: Pancreatic carcinoma (PC) is the one of the most common and malignant cancers worldwide. LncRNA taurine upregulated gene 1 (TUG1) was initially identified as a transcript upregulated by taurine, and the abnormal expression of TUG1 has been reported in many cancers. However, the biological role and molecular mechanism of TUG1 in PC still needs further investigation. METHODS: Quantitative real-time PCR (qRT-PCR) was performed to measure the expression of TUG1 in PC cell lines and tissues...
August 15, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28796375/effects-of-long-noncoding-rna-spry4-it1-mediated-ezh2-on-the-invasion-and-migration-of-lung-adenocarcinoma
#17
Xin Wen, Xin-Rui Han, Yong-Jian Wang, Shao-Hua Fan, Juan Zhuang, Zi-Feng Zhang, Qun Shan, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Qiao Wu, Jun-Hua Tan, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
We aim to investigate the interaction between the EZH2 and the long noncoding RNA (lncRNA) SPRY4-IT1. We also explore their respective effects on human lung adenocarcinoma (LA) cell invasion and migration. Both LA and adjacent normal tissues were obtained from 256 LA patients. SPTY4-IT expression and EZH2 mRNA expressions in tissues and cells were detected by reverse transcription quantitative polymerase chain reaction (RT-qPCR). The siRNAs against SPRY4-IT1 and EZH2 were co-transfected into A549 and H1975 cells...
August 10, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28779971/lncrna-h19-regulates-epithelial-mesenchymal-transition-and-metastasis-of-bladder-cancer-by-mir-29b-3p-as-competing-endogenous-rna
#18
Mengxin Lv, Zhenyu Zhong, Mengge Huang, Qiang Tian, Rong Jiang, Junxia Chen
Accumulating evidences indicate that long noncoding RNAs (lncRNAs) might play important roles in tumorigenesis and metastasis. EMT (epithelial-to-mesenchymal transition) is considered as a critical step in invasion and metastasis of various tumors including bladder cancer (BC). Recent researches have showed that lncRNA H19 is implicated in metastasis through regulating EMT and the reverse MET (mesenchymal-to-epithelial transition). However, underlying mechanisms remain largely unknown. Here, we screened lncRNA and mRNA expression profiles of BC with microarray assay...
August 2, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28772210/lncrna-ghet1-activated-by-h3k27-acetylation-promotes-cell-tumorigenesis-through-regulating-atf1-in-hepatocellular-carcinoma
#19
Gangqiang Ding, Wei Li, Junping Liu, Yanli Zeng, Chongshan Mao, Yi Kang, Jia Shang
BACKGROUND: GHET1 is one of tumor-related lncRNAs. We aimed to explore the functional involvement of GHET1 in hepatocellular carcinoma (HCC). METHODS: In this study, HCC tissues and the paired normal tissues were collected for the detection of target molecules. The expression level of target molecules in HCC tissues or cell lines was determined by qRT-PCR and western blot, respectively. The expression of endogenous GHET1 and ATF1 was modulated by using cell transfection...
October 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28770968/lncrna-malat1-promotes-proliferation-and-metastasis-in-epithelial-ovarian-cancer-via-the-pi3k-akt-pathway
#20
Y Jin, S-J Feng, S Qiu, N Shao, J-H Zheng
OBJECTIVE: The metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA) that plays a key role in the malignant phenotype of tumors. Although abnormal regulation of lncRNA MALAT1 impacts clinical prognostic and tumor metastasis, its function remains unclear in ovarian cancer. PATIENTS AND METHODS: We collected 64 samples of surgical EOC tissues and 30 samples of normal ovarian tissues at the Department of Gynecology of Harbin Medical University (Harbin, China)...
July 2017: European Review for Medical and Pharmacological Sciences
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