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https://www.readbyqxmd.com/read/29600982/variant-of-rare-hermansky-pudlak-syndrome-associated-with-granulomatous-colitis-diagnostics-clinical-course-and-treatment
#1
L Y Lozynska, A Plawski, M R Lozynska, I Vytvytskyi, R Y Lozynskyi, N Prokopchuk, B Tretiak
AIM: To study the relationship between the genotype and the phenotype in the patients with Hermansky - Pudlak syndrome (HPS) associated with granulomatous colitis; to monitor clinical course of the disease for adequate treatment, cancer surveillance and genetic counseling. MATERIALS AND METHODS: The diagnosis of HPS is established by physical examination, chest X-ray, computed tomography, endoscopic examination with biopsy, and laboratory tests, including histology, baseline laboratory blood, urine and feces tests, determination of ASCA-C and ANCA antibodies using an ELISA...
March 2018: Experimental Oncology
https://www.readbyqxmd.com/read/29590158/significance-of-serological-markers-in-the-disease-course-of-ulcerative-colitis-in-a-prospective-clinical-cohort-of-patients
#2
Gyorgy Kovacs, Nora Sipeki, Boglarka Suga, Tamas Tornai, Kai Fechner, Gary L Norman, Zakera Shums, Peter Antal-Szalmas, Maria Papp
BACKGROUND & AIMS: To determine the prognostic potential of classic and novel serologic antibodies regarding unfavorable disease course in a prospective ulcerative colitis (UC) patient cohort, since few and conflicting data are available in the literature regarding this matter. METHODS: 187 consecutive patients were studied prospectively (median follow-up: 135 months) from a single referral IBD center in Hungary. Sera were tested for different IgA/IgG type autoantibodies (anti-neutrophil cytoplasmic [ANCA], anti-DNA-bound-lactoferrin [anti-LFS], anti-goblet cell [anti-GAB] and anti-pancreatic [PAB: anti-CUZD1 and anti-GP2)]) by indirect immunofluorescence technique and for anti-microbial (anti-Saccharomyces cerevisiae [ASCA] IgG/IgA and anti-OMP Plus™ IgA) antibodies by enzyme-linked immunosorbent assays...
2018: PloS One
https://www.readbyqxmd.com/read/29561467/asca-anti-saccharomyces-cerevisiae-antibody-in-patients-with-scleroderma
#3
Aiessa Fedrigo, Thelma L Skare, André Luiz Bortoluzzi, Renato Nisihara
OBJECTIVES: The majority of scleroderma (SSc) patients present gastrointestinal involvement. Motility is usually compromised but few studies address permeability changes in the intestinal wall. ASCA (anti-Saccharomyces cerevisiae antibodies) positivity is associated with increased intestinal permeability. In this study we aimed to investigate ASCA positivity in SSc patients and its association with clinical, serological and epidemiological data. METHODS: Seventy-four SSc patients and 57 healthy controls were studied for ASCA (IgG and IgA) positivity by ELISA...
March 21, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29519712/t300a-variant-of-at16l1-gene-in-a-cohort-of-algerian-crohn-disease-patients
#4
I Aida, Y Meddour, H Kadiri, M Smara, A Bousseloub, L Kecili, L Gamar, K Belhocine, M-A Boussafsaf, N Debzi, S Aouichat-Bouguerra, S Chaib
The T300A variant is among the most Crohn's disease (CD) associated genetic variants. The aim of our study is to bring a first insight about the contribution of the T300A variant in a cohort of Algerian CD. In a case/control design, 118 Algerian CD patients and 161 unrelated healthy subjects were genotyped for the T300A variant using the allelic discrimination test by Applied Biosystems Taqman® genotyping technology. A serological analysis was carried out using Biosystems™ ELISA kit for the assessment of the anti-Saccharomyces cerevisiae antibodies and immunofluorimetry via Luminex® technology for the evaluation of cytokine levels (TNFα, IFNγ, IL-6 and IL-17)...
March 5, 2018: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/29486565/probing-liquid-solid-and-vapor-liquid-solid-interfaces-of-hierarchical-surfaces-using-high-resolution-microscopy
#5
Katherine T Flynn Bolte, Rajesh Prabhu Balaraman, Kexin Jiao, Michael D Tustison, Kiah S Kirkwood, Chuanhong Zhou, Punit Kohli
Liquid-solid (LS) and vapor-liquid-solid (VLS) interfaces are important to the fundamental understanding of how surface chemistry impacts industrial processes and applications. Superhydrophobic surfaces, from structural hierarchies, were fabricated by coating flat smooth surfaces with hollow glass microspheres. These surfaces are referred to as structural hierarchical modified microsphere surfaces (SHiMMs). Two phase LS and three-phase VLS interfaces of water droplets on SHiMMs, with an apparent static contact angle (aSCA) of ~160° were probed at microscale using environmental scanning electron microscopy (ESEM) and high resolution optical microscopy (OM)...
February 28, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29446764/antibodies-against-glycoprotein-2-display-diagnostic-advantages-over-asca-in-distinguishing-cd-from-intestinal-tuberculosis-and-intestinal-beh%C3%A3-et-s-disease
#6
Shulan Zhang, Jing Luo, Ziyan Wu, Dirk Roggenbuck, Peter Schierack, Dirk Reinhold, Ji Li, Xiaofeng Zeng, Fengchun Zhang, Jiaming Qian, Yongzhe Li
OBJECTIVES: There is an increasing need to identify reliable biomarkers for distinguishing Crohn's disease (CD) from other gastrointestinal disorders sharing similar clinical and pathological features. This study aimed at evaluating the diagnostic potential of antibodies to zymogen granule glycoprotein GP2 (aGP2) in a large, well-defined Chinese cohort with a special focus on their role in discriminating CD from intestinal Behçet's disease (BD) and intestinal tubercolosis (ITB). METHODS: A total of 577 subjects were prospectively enrolled, including 171 patients with CD, 208 patients with ulcerative colitis (UC), 71 with BD, 57 with ITB and 70 healthy controls (HC)...
February 15, 2018: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29434451/impaired-granulocyte-macrophage-colony-stimulating-factor-bioactivity-accelerates-surgical-recurrence-in-ileal-crohn-s-disease
#7
Grace Gathungu, Yuanhao Zhang, Xinyu Tian, Erin Bonkowski, Leahana Rowehl, Julia Krumsiek, Billy Nix, Claudia Chalk, Bruce Trapnell, Wei Zhu, Rodney Newberry, Lee Denson, Ellen Li
AIM: To examine the relationship between elevated granulocyte-macrophage colony-stimulating factor (GM-CSF) auto-antibodies (Ab) level and time to surgical recurrence after initial surgery for Crohn's disease (CD). METHODS: We reviewed 412 charts from a clinical database at tertiary academic hospital. Patients included in the study had ileal or ileocolonic CD and surgical resection of small bowel or ileocecal region for management of disease. Serum samples were analyzed for serological assays including GM-CSF cytokine, GM-CSF Ab, ASCA IgG and IgA, and genetic markers including SNPs rs2066843, rs2066844, rs2066845, rs2076756 and rs2066847 in NOD2, rs2241880 in ATG16L1, and rs13361189 in IRGM...
February 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29398466/relationship-between-fecal-calprotectin-anti-saccharomyces-cerevisiae-antibodies-and-other-markers-of-disease-activity-in-patients-with-spondyloarthritis
#8
María José Moreno Martínez, Manuel José Moreno Ramos, Luis Francisco Linares Ferrando
OBJECTIVE: To assess the relationship between the increase of fecal calprotectin, anti-Saccharomyces cerevisiae antibodies (ASCA) and disease markers in a group of patients with spondyloarthritis. METHODS: We evaluated patients who were at least 18-years-old and met the Assessment in Spondyloarthritis International Society (ASAS) criteria for spondyloarthritis or the New York modified criteria. We analyzed activity criteria, physical function, analytical criteria (human leukocyte antigen [HLA] B27, fecal calprotectin, presence of ASCA, among others) and demographic data...
February 1, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29347958/correlation-of-structural-defects-in-the-ascending-aortic-wall-to-ultrasound-parameters-benefits-for-decision-making-process-in-aortic-valve-surgery
#9
Saša D Borović, Milica M Labudović Borović, Ivan V Zaletel, Vera N Todorović, Petar A Dabić, Jelena T Rakočević, Jelena M Marinković-Erić, Predrag S Milojević
BACKGROUND: Histopathological changes in the ascending aorta wall in patients with severe tricuspid aortic valve (TAV) stenosis were graded and correlated to echocardiographic parameters. Objective was to associate threshold echocardiographic values with structural defects in the ascending aorta providing a tool to improve decision-making process in cases when simultaneous aortic valve replacement (AVR) and ascending aorta replacement is considered. METHODS: Biopsies from 108 TAV stenosis patients subjected to AVR were graded into three grades according to severity of aortic wall changes...
January 18, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29213287/gastrointestinal-symptoms-and-elevated-levels-of-anti-saccharomyces-cerevisiae-antibodies-are-associated-with-higher-disease-activity-in-colombian-patients-with-spondyloarthritis
#10
C Romero-Sánchez, W Bautista-Molano, V Parra, J De Avila, J C Rueda, J M Bello-Gualtero, J Londoño, R Valle-Oñate
Background: Spondyloarthritis (SpA) is a group of articular inflammatory rheumatic diseases that their gastrointestinal manifestations are around 10% of their extra-articular symptoms, supporting that the inflammatory response of the intestinal mucosa could be associated with the clinical status. Objectives: To investigate the association between gastrointestinal symptoms and autoantibodies and disease activity between SpA patients, healthy subjects (HS), and patients with inflammatory bowel disease (IBD)...
2017: International Journal of Rheumatology
https://www.readbyqxmd.com/read/29142473/genetic-associations-with-adverse-events-from-anti-tumor-necrosis-factor-therapy-in-inflammatory-bowel-disease-patients
#11
Daniel Lew, Soon Man Yoon, Xiaofei Yan, Lori Robbins, Talin Haritunians, Zhenqiu Liu, Dalin Li, Dermot Pb McGovern
AIM: To study the type and frequency of adverse events associated with anti-tumor necrosis factor (TNF) therapy and evaluate for any serologic and genetic associations. METHODS: This study was a retrospective review of patients attending the inflammatory bowel disease (IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol...
October 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29064436/modelling-of-hydrophilic-interaction-liquid-chromatography-stationary-phases-using-chemometric-approaches
#12
Meritxell Navarro-Reig, Elena Ortiz-Villanueva, Romà Tauler, Joaquim Jaumot
Metabolomics is a powerful and widely used approach that aims to screen endogenous small molecules (metabolites) of different families present in biological samples. The large variety of compounds to be determined and their wide diversity of physical and chemical properties have promoted the development of different types of hydrophilic interaction liquid chromatography (HILIC) stationary phases. However, the selection of the most suitable HILIC stationary phase is not straightforward. In this work, four different HILIC stationary phases have been compared to evaluate their potential application for the analysis of a complex mixture of metabolites, a situation similar to that found in non-targeted metabolomics studies...
October 24, 2017: Metabolites
https://www.readbyqxmd.com/read/29034577/untargeted-gc-ms-metabolomics-reveals-changes-in-the-metabolite-dynamics-of-industrial-scale-batch-fermentations-of-streptoccoccus-thermophilus-broth
#13
Bekzod Khakimov, Lene D Christiansen, Anna-Lena Heins, Klavs M Sørensen, Charlotte Schöller, Anders Clausen, Thomas Skov, Krist V Gernaey, Søren B Engelsen
An industrial scale biomass production using batch or fed-batch fermentations usually optimized by selection of bacterial strains, tuning fermentation media, feeding strategy, and temperature. However, in-depth investigation of the biomass metabolome during the production may reveal new knowledge for better optimization. In this study, for the first time, the authors investigated seven fermentation batches performed on five Streptoccoccus thermophilus strains during the biomass production at Chr. Hansen (Denmark) in a real life large scale fermentation process...
October 16, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28822928/combined-effects-of-salinity-temperature-and-hypoxia-on-daphnia-magna-metabolism
#14
Elba Garreta-Lara, Bruno Campos, Carlos Barata, Silvia Lacorte, Romà Tauler
Metabolic changes of Daphnia magna pools due different abiotic factors linked to global climate change (salinity, temperature and hypoxia) were investigated using untargeted GC-MS and advanced chemometric strategies using a three factors two-level full factorial experimental design (DoE). Effects of these three factors and identity of the metabolites whose concentrations changed because of them were investigated. The simultaneous analysis of GC-MS data sets using Multivariate Curve Resolution-Alternating Least Squares (MCR-ALS) allowed the resolution of the elution and mass spectra profiles of a large number of D...
January 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/28802139/analysis-of-neurobehavioural-data-by-chemometric-methods-in-ecotoxicological-studies
#15
Cristian Gómez-Canela, Eva Prats, Romà Tauler, Demetrio Raldúa
Incorporation of chemometric tools in behavioural data management workflows allows for the early identification of most relevant endpoints complementarily to statistical confirmatory approaches. In this work, the effects of two model neurotoxicants, chlorpyrifos (CPF) and nicotine, exposures on behavioural profiles of adult zebrafish at three different times (2, 6 and 24h) were evaluated using open field test (OFT) paradigm experiments. Two chemometric methods like Principal Component Analysis (PCA) and Analysis of Variance-Simultaneous Component Analysis (ASCA) have been used to interpret the changes observed in the obtained behavioural data...
November 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28745018/a-comparison-between-linguistic-skills-and-socio-communicative-abilities-in-williams-syndrome
#16
P Alfieri, D Menghini, L Marotta, L De Peppo, L Ravà, F Salvaguardia, C Varuzza, S Vicari
BACKGROUND: Individuals with Williams syndrome (WS) show a disharmonic linguistic profile with a clear pattern of strengths and weaknesses. Despite their sociable nature, atypical socio-communicative abilities and deficits in communication and relationship with others have been found. AIM: The aim of the present study was to investigate whether linguistic skills (LS) were in line with the pragmatic and social use of language and the cognitive development of 32 individuals with WS (18 boys and 14 girls) with a mean chronological age of 12...
September 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28725447/anti-saccharomyces-cerevisiae-antibodies-asca-are-associated-with-body-fat-mass-and-systemic-inflammation-but-not-with-dietary-yeast-consumption-a-cross-sectional-study
#17
Anne Stine Kvehaugen, Martin Aasbrenn, Per G Farup
BACKGROUND: Baker's/brewer's yeast, Saccharomyces cerevisiae, has been used as an alternative to antibiotic growth promoters to improve growth performance in animals. In humans, Saccharomyces cerevisiae is among the most commonly detected fungi in fecal samples and likely originates from food. Recently, an association between anti-Saccharomyces cerevisiae antibodies (ASCA) and obesity in humans was suggested, but the cause of the elevated ASCA levels is not clear. Our aim was to study ASCA in morbidly obese subjects and explore potential associations with anthropometrics, diet, co-morbidities and biomarkers of inflammation and gut permeability...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28692288/toward-reliable-lipoprotein-particle-predictions-from-nmr-spectra-of-human-blood-an-interlaboratory-ring-test
#18
Sandra Monsonis Centelles, Huub C J Hoefsloot, Bekzod Khakimov, Parvaneh Ebrahimi, Mads V Lind, Mette Kristensen, Niels de Roo, Doris M Jacobs, John van Duynhoven, Claire Cannet, Fang Fang, Eberhard Humpfer, Hartmut Schäfer, Manfred Spraul, Søren B Engelsen, Age K Smilde
Lipoprotein profiling of human blood by (1)H nuclear magnetic resonance (NMR) spectroscopy is a rapid and promising approach to monitor health and disease states in medicine and nutrition. However, lack of standardization of measurement protocols has prevented the use of NMR-based lipoprotein profiling in metastudies. In this study, a standardized NMR measurement protocol was applied in a ring test performed across three different laboratories in Europe on plasma and serum samples from 28 individuals. Data was evaluated in terms of (i) spectral differences, (ii) differences in LPD predictions obtained using an existing prediction model, and (iii) agreement of predictions with cholesterol concentrations in high- and low-density lipoproteins (HDL and LDL) particles measured by standardized clinical assays...
August 1, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28664835/prevalence-and-significance-of-anti-saccharomyces-cerevisiae-antibodies-in-primary-sj%C3%A3-gren-s-syndrome
#19
Alessia Alunno, Onelia Bistoni, Francesco Carubbi, Valentina Valentini, Giacomo Cafaro, Elena Bartoloni Bocci, Roberto Giacomelli, Roberto Gerli
OBJECTIVES: Saccharomyces cerevisiae is a common yeast used in the food industry. IgG and IgA antibodies against the phosphopeptidomannan of the S. cerevisiae cell wall (ASCA) are a well known marker of disease severity in Crohn's disease. Moreover, a number of studies assessed ASCA in several systemic and organ-specific autoimmune diseases postulating molecular mimicry as a possible link between ASCA and autoimmunity. However, since they have never been tested in primary Sjögren's syndrome (pSS), the purpose of this study was to investigate these antibodies in a large cohort of pSS patients, compared to healthy donors (HD), and their significance as potentially helpful biomarker in a clinical setting...
June 29, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28661185/the-value-of-serum-antibodies-in-differentiating-inflammatory-bowel-disease-predicting-disease-activity-and-disease-course-in-the-newly-diagnosed-patient
#20
Carolijn Smids, Carmen S Horjus Talabur Horje, Marcel J M Groenen, Elly H M van Koolwijk, Peter J Wahab, Ellen G van Lochem
BACKGROUND: Data on serum antibodies in untreated adult inflammatory bowel disease (IBD) patients at diagnosis are scarcely available, and results on the stability of antibody presence over time are inconsistent. Our aim was to investigate antibodies in newly diagnosed, untreated IBD patients in relation to disease phenotype and course. Furthermore, we analyzed antibody presence over time. METHODS: Baseline anti-Saccharomyces cerevisiae antibodies (ASCA), anti-chitobioside carbohydrate antibodies (ACCA), anti-laminaribioside carbohydrate antibodies (ALCA) and anti-mannobioside carbohydrate antibodies (AMCA) were measured with enzyme-linked immunosorbent assays and perinuclear anti-neutrophilic cytoplasmic antibodies (pANCA) was measured by indirect immunofluorescence in serum of 120 untreated IBD patients at diagnosis and 19 healthy controls...
June 29, 2017: Scandinavian Journal of Gastroenterology
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