Ka Yu Carissa Kwan, Ka Wai Kerry Ng, Ying Rao, Chenxian Zhu, Shengcai Qi, Rocky S Tuan, Dai Fei Elmer Ker, Dan Michelle Wang
Tendon aging is associated with an increasing prevalence of tendon injuries and/or chronic tendon diseases, such as tendinopathy, which affects approximately 25% of the adult population. Aged tendons are often characterized by a reduction in the number and functionality of tendon stem/progenitor cells (TSPCs), fragmented or disorganized collagen bundles, and an increased deposition of glycosaminoglycans (GAGs), leading to pain, inflammation, and impaired mobility. Although the exact pathology is unknown, overuse and microtrauma from aging are thought to be major causative factors...
October 14, 2023: International Journal of Molecular Sciences