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https://www.readbyqxmd.com/read/28102152/solanezumab-too-late-in-mild-alzheimer-s-disease
#1
EDITORIAL
The Lancet Neurology
No abstract text is available yet for this article.
February 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28102125/aca-repeal-and-the-ama
#2
EDITORIAL
The Lancet
No abstract text is available yet for this article.
January 14, 2017: Lancet
https://www.readbyqxmd.com/read/28102124/clinical-guidance-for-bronchiolitis
#3
EDITORIAL
The Lancet
No abstract text is available yet for this article.
January 14, 2017: Lancet
https://www.readbyqxmd.com/read/28102123/health-in-india-2017
#4
EDITORIAL
The Lancet
No abstract text is available yet for this article.
January 14, 2017: Lancet
https://www.readbyqxmd.com/read/28096534/novel-therapeutic-approach-to-improve-hematopoiesis-in-low-risk-mds-by-targeting-mdscs-with-the-fc-engineered-cd33-antibody-bi-836858
#5
E A Eksioglu, X Chen, K-H Heider, B Rueter, K L McGraw, A A Basiorka, M Wei, A Burnette, P Cheng, J Lancet, R Komrokji, J Djeu, A List, S Wei
We recently reported that the accumulation of myeloid-derived suppressor cells (MDSC), defined as CD33(+)HLA-DR(-)Lin(-), plays a direct role in the pathogenesis of myelodysplastic syndrome (MDS). In particular, CD33 is strongly expressed in MDSC isolated from patients with MDS where it plays an important role in MDSC-mediated hematopoietic suppressive function through its activation by S100A9. Therefore, we tested whether blocking this interaction with a fully human, Fc-engineered monoclonal antibody against CD33 (BI 836858) suppresses CD33-mediated signal transduction and improves the bone marrow microenvironment in MDS...
January 18, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28091366/trastuzumab-emtansine-and-cost-based-decision-making
#6
EDITORIAL
The Lancet
No abstract text is available yet for this article.
January 7, 2017: Lancet
https://www.readbyqxmd.com/read/28091365/suicide-among-health-care-workers-time-to-act
#7
EDITORIAL
The Lancet
No abstract text is available yet for this article.
January 7, 2017: Lancet
https://www.readbyqxmd.com/read/28091363/obesity-and-diabetes-in-2017-a-new-year
#8
EDITORIAL
The Lancet
No abstract text is available yet for this article.
January 7, 2017: Lancet
https://www.readbyqxmd.com/read/28090524/the-samukeppra-study-in-prehospital-status-epilepticus-lessons-for-future-study
#9
COMMENT
Andrew C Schomer, Jaideep Kapur
In the Lancet Neurology article "Prehospital treatment with levetiracetam plus clonazepam or placebo plus clonazepam in status epilepticus (SAMUKeppra): a randomised, double-blind, phase 3 trial" the authors conducted a prehospital, randomized controlled study to determine which treatment is more effective for status epilepticus (SE): benzodiazepine alone, or in combination with levetiracetam (LEV). Although the study had negative results, several aspects of the trial design likely masked any added effect that LEV may have had in controlling SE, including: higher doses of benzodiazepines, lower thresholds for determining cessation of SE, and a smaller sample size...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28089312/hunting-down-an-evidence-base-for-adolescent-mental-health
#10
EDITORIAL
The Lancet Psychiatry
No abstract text is available yet for this article.
January 11, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28075182/dispersing-the-mists-an-experimental-history-of-medicine-study-into-the-quality-of-volatile-inhalations
#11
Barry Murnane, Cathal T Gallagher, Noel Snell, Mark Sanders, Ramin Moshksar, Darragh Murnane
BACKGROUND: Dr. Nelson's Improved Inhaler was first marketed with an advertisement in The Lancet in 1865. Revolutionary at the time for its ease of use and patient-friendliness, the inhaler is still in use for self-treatment by many all over the world. On the occasion of its 150th anniversary, this study reports an experimental historical medicine approach to identify evidence for the quality of vapor inhalers. METHODS: Through accessing reviews of the device's use by the contemporary medical establishment, it was established that Dr...
January 11, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28066825/a-blinded-randomised-placebo-controlled-trial-investigating-the-efficacy-of-morphine-analgesia-for-procedural-pain-in-infants-trial-protocol
#12
Rebeccah Slater, Caroline Hartley, Fiona Moultrie, Eleri Adams, Ed Juszczak, Richard Rogers, Jane E Norman, Chetan Patel, Kayleigh Stanbury, Amy Hoskin, Gabrielle Green
Infant pain has both immediate and long-term negative consequences, yet in clinical practice it is often undertreated. To date, few pain-relieving drugs have been tested in infants. Morphine is a potent analgesic that provides effective pain relief in adults, but there is inconclusive evidence for its effectiveness in infants. The purpose of this study is to establish whether oral morphine provides effective analgesia for procedural pain in infants. A blinded, placebo-controlled, parallel-group randomized, phase II, clinical trial will be undertaken to determine whether morphine sulphate administered orally prior to clinically-required retinopathy of prematurity (ROP) screening and heel lancing provides effective analgesia...
November 15, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28064463/global-research-trends-in-lithium-toxicity-from-1913-to-2015-a-bibliometric-analysis
#13
Sa'ed H Zyoud, W Stephen Waring, Waleed M Sweileh, Samah W Al-Jabi
Lithium salts have been used to treat psychiatric disorders since the 1940s and are currently used in prophylaxis and treatment of depression and bipolar disorder. Therefore, we conducted this study to assess lithium toxicity-related publications using bibliometric approaches from a health point of view to assess global research trends in the lithium toxicity field to offer guidance to future research in this field. The data were retrieved from the online version of Scopus database on 6 August 2016. All records with the term "lithium" in the title were retrieved, and those related to lithium toxicity were evaluated...
January 8, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28060886/point-of-care-p24-infant-testing-for-hiv-may-increase-patient-identification-despite-low-sensitivity
#14
Bindiya Meggi, Timothy Bollinger, Nédio Mabunda, Adolfo Vubil, Ocean Tobaiwa, Jorge I Quevedo, Osvaldo Loquiha, Lara Vojnov, Trevor F Peter, Ilesh V Jani
The long delay in returning test results during early infant diagnosis of HIV (EID) often causes loss-to-follow-up prior to antiretroviral treatment (ART) initiation in resource-limited settings. A point-of-care (POC) test may help overcome these challenges. We evaluated the performance of the LYNX p24 Antigen POC test in Mozambique. 879 HIV-exposed infants under 18 months of age were enrolled consecutively at three primary healthcare clinics (PHC). Lancet heel-drawn blood was tested on-site by nurses using a prototype POC test for HIV Gag p24 antigen detection...
2017: PloS One
https://www.readbyqxmd.com/read/28050393/metronomic-chemotherapy-seems-prowess-to-battle-against-cancer-in-current-scenario
#15
Prema Muthusamy, Krishnan Vengadaragava Chary, G K Nalini
INTRODUCTION: Metronomic chemotherapy is an emerging method of chemotherapy. Metronomic 'lowdose' chemotherapy regimen induces tumour dormancy and reduces cancer resistance against anticancer drugs. It tends to improve overall success rate of cancer chemotherapy than conventional cyclical regimen. AIM: The aim of this systemic review was to provide comprehensive data of metronomic chemotherapy trials, regimens used and it's outcome in cancer therapeutics. MATERIALS AND METHODS: Fifty chemotherapy trial data were searched sequentially from web...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28049567/cannabis-high-time-for-evidence-based-policies
#16
EDITORIAL
The Lancet Oncology
No abstract text is available yet for this article.
January 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28048284/su-f-p-08-medical-physics-perspective-on-radiation-therapy-quality-and-safety-considerations-in-low-income-settings
#17
J Van Dyk, A Meghzifene
PURPOSE: The last few years have seen a significant growth of interest in the global radiation therapy crisis. Various organizations are quantifying the need and providing aid in support of addressing the shortfall existing in many low-to-middle income countries (LMICs). The Lancet Oncology Commission report (Lancet Oncol. Sep;16(10):1153-86, 2015) projects a need of 22,000 new medical physicists in LMICs by 2035 if there is to be equal access globally. With the tremendous demand for new facilities, equipment and personnel, it is very important to recognize quality and safety considerations and to address them directly...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28041581/clinical-trial-reporting-an-evolving-process
#18
EDITORIAL
The Lancet Haematology
No abstract text is available yet for this article.
January 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28040092/global-access-to-radiotherapy-in-low-and-middle-income-countries
#19
M Abdel-Wahab, E Fidarova, A Polo
Over the last 60 years, the International Atomic Energy Agency (IAEA) has been working to introduce, expand and improve radiotherapy services, working with partners such as the World Health Organization (WHO) to improve cancer diagnosis, treatment, care and control through collective action in low- and middle-income countries (LMICs). The Lancet Oncology Commission on radiotherapy published a report that defined five calls for action to expand global access to radiotherapy, drawing on the previous work of the Global Taskforce on Radiotherapy for Cancer Control...
February 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28032479/the-role-of-nutrition-in-integrated-early-child-development-in-the-21st-century-contribution-from-the-maternal-and-child-nutrition-journal
#20
EDITORIAL
Rafael Pérez-Escamilla, Victoria Hall Moran
Even though it is widely recognized that early childhood development (ECD) is one of the most important predictors of future social capital and national productivity, the recently published ECD Lancet Series reports that about 250 million children under 5 years are at risk of not reaching their developmental potential, mainly as a result of poverty and social injustice. So why is this and what will it take to reverse this situation? The purpose of this special issue is to highlight important contributions from previously published articles in Maternal & Child Nutrition to the field of nutrition and ECD...
January 2017: Maternal & Child Nutrition
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