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Ischemia angiogenesis

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https://www.readbyqxmd.com/read/28320183/ischemic-optic-neuropathy-as-a-model-of-neurodegenerative-disorder-a-review-of-pathogenic-mechanism-of-axonal-degeneration-and-the-role-of-neuroprotection
#1
REVIEW
Saba Khalilpour, Shahrzad Latifi, Ghazaleh Behnammanesh, Amin Malik Shah Abdul Majid, Aman Shah Abdul Majid, Ali Tamayol
Optic neuropathy is a neurodegenerative disease which involves optic nerve injury. It is caused by acute or intermittent insults leading to visual dysfunction. There are number of factors, responsible for optic neuropathy, and the optic nerve axon is affected in all type which causes the loss of retinal ganglion cells. In this review we will highlight various mechanisms involved in the cell loss cascades during axonal degeneration as well as ischemic optic neuropathy. These mechanisms include oxidative stress, excitotoxicity, angiogenesis, neuroinflammation and apoptosis following retinal ischemia...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28316070/the-involvement-of-thrombin-in-the-pathogenesis-of-glioblastoma
#2
REVIEW
Harald Krenzlin, Viola Lorenz, Beat Alessandri
Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra-hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various degenerative and ischemic CNS diseases like Alzheimer's, multiple sclerosis, cerebral ischemia, and hemorrhage in a dose dependent manner. Additionally, the association of thrombin with various malignancies has recently become evident. Thrombin facilitates the interaction between tumor cells with platelets, endothelial cells, and the adhesion to matrix proteins in various tumor types...
March 19, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28302707/neuropeptide-y3-36-incorporated-into-pvax-nanoparticle-improves-functional-blood-flow-in-a-murine-model-of-hind-limb-ischemia
#3
Derek Eshun, Rabya Saraf, Soochan Bae, Jelliffe Jeganathan, Feroze Mahmood, Serkan Dilmen, Qingen Ke, Dongwon Lee, Peter M Kang, Robina Matyal
We generated a novel nanoparticle called PVAX, which has intrinsic anti-apoptotic and anti-inflammatory properties. This nanoparticle was loaded with Neuropeptide Y3-36, an angiogenic neuro-hormone that plays a central role in angiogenesis. Subsequently, we investigated whether PVAX-NPY3-36 could act as a therapeutic agent and induce angiogenesis and vascular remodeling in a murine model of hind limb ischemia. Adult C57BL/J6 mice (n=40) were assigned to treatment groups: Control, Ischemia PBS, Ischemia PVAX, Ischemia NPY3-36, and Ischemia PVAX-NPY3-36 Ischemia was induced by ligation of the femoral artery in all groups except Control and given relevant treatments (PBS, PVAX, NPY3-36, and PVAX-NPY3-36)...
March 16, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28300551/role-of-caveolin-1-vascular-endothelial-growth-factor-pathway-in-basic-fibroblast-growth-factor-induced-angiogenesis-and-neurogenesis-after-treadmill-training-following-focal-cerebral-ischemia-in-rats
#4
Qiongyi Pang, Huimei Zhang, Zhenzhen Chen, Yudan Wu, Min Yidian Bai Liu, Yun Zhao, Fengxia Tu, Chan Liu, Xiang Chen
Exercise is known to aid functional recovery following ischemia, though the mechanisms responsible for the beneficial effects of exercise on recovery from ischemic stroke are not fully understood. Basic fibroblast growth factor (bFGF) contributes to angiogenesis and promotes neurologic functional recovery after stroke. The present study aimed to investigate the possible mechanisms whereby treadmill exercise ameliorated impaired angiogenesis and neurogenesis following transient cerebral ischemia in middle cerebral artery occlusion (MCAO) rats...
March 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28298297/angiogenic-mechanisms-of-human-cd34-stem-cell-exosomes-in-the-repair-of-ischemic-hindlimb
#5
Prabhu Mathiyalagan, Yaxuan Liang, David Kim, Sol Misener, Tina Thorne, Christine Kamide, Ekaterina Klyachko, Douglas W Losordo, Roger J Hajjar, Susmita Sahoo
Rationale: Paracrine secretions appear to mediate therapeutic effects of human CD34(+) stem cells locally transplanted in patients with myocardial and critical limb ischemia as well as in animal models. Earlier, we had discovered that paracrine secretion from human CD34(+) cells contains pro-angiogenic, membrane-bound nano-vesicles called exosomes (CD34Exo). Objective: Here, we investigated the mechanisms of CD34Exo-mediated ischemic tissue repair and therapeutic angiogenesis by studying their miRNA content and uptake...
March 15, 2017: Circulation Research
https://www.readbyqxmd.com/read/28291543/cell-membrane-integrity-and-revascularization-the-possible-functional-mechanism-of-ischemic-preconditioning-for-skeletal-muscle-protection-against-ischemic-reperfusion-injury
#6
Yang Hong, Bin Zhang, Ling Yu, Shan-Shan Duan
BACKGROUND: The purpose of this paper was to evaluate whether ischemic preconditioning (IPC) could make protective effects against skeletal muscle injuries induced by ischemic-reperfusion (I/R). METHODS: Eighteen rats were randomly divided into three groups of 6 subjects each: control group, I/R group, and IPC group. Thigh root ischemia of rats in the I/R group was induced by 3h ischemia and 24h reperfusion. IPC was applied by 3 periods of 15min ischemia/15min reperfusion prior to ischemia...
March 10, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28287533/isolation-of-endothelial-progenitor-cells-from-healthy-volunteers-and-their-migratory-potential-influenced-by-serum-samples-after-cardiac-surgery
#7
Christoph Emontzpohl, David Simons, Sandra Kraemer, Andreas Goetzenich, Gernot Marx, Jürgen Bernhagen, Christian Stoppe
Endothelial progenitor cells (EPCs) are recruited from the bone marrow under pathological conditions like hypoxia and are crucially involved in the neovascularization of ischemic tissues. The origin, classification and characterization of EPCs are complex; notwithstanding, two prominent sub-types of EPCs have been established: so-called "early" EPCs (subsequently referred to as early-EPCs) and late-outgrowth EPCs (late-EPCs). They can be classified by biological properties as well as by their appearance during in vitro culture...
February 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28286751/new-delivery-systems-of-stem-cells-for-vascular-regeneration-in-ischemia
#8
REVIEW
Adegbenro Omotuyi John Fakoya
The finances of patients and countries are increasingly overwhelmed with the plague of cardiovascular diseases as a result of having to chronically manage the associated complications of ischemia such as heart failures, neurological deficits, chronic limb ulcers, gangrenes, and amputations. Hence, scientific research has sought for alternate therapies since pharmacological and surgical treatments have fallen below expectations in providing the desired quality of life. The advent of stem cells research has raised expectations with respect to vascular regeneration and tissue remodeling, hence assuring the patients of the possibility of an improved quality of life...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28285076/functional-poly-%C3%AE%C2%B5-caprolactone-chitosan-dressings-with-nitric-oxide-releasing-property-improve-wound-healing
#9
Xin Zhou, He Wang, Jimin Zhang, Xuemei Li, Yifan Wu, Yongzhen Wei, Ji Shenglu, Deling Kong, Qiang Zhao
Wound healing dressings are increasingly needed clinically due to the large number of skin damage annually. Nitric oxide (NO) plays a key role in promoting wound healing, thus biomaterials with NO-releasing property receive increasing attention as ideal wound dressing. In present study, we prepared a novel functional wound dressing by combining electrospun poly(ε-caprolactone) (PCL) nonwoven mat with chitosan-based NO-releasing biomaterials (CS-NO). As-prepared PCL/CS-NO dressing released NO sustainably under the physiological conditions, which was controlled by the catalysis of β-galactosidase...
March 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28284901/the-application-and-neuroprotective-mechanisms-of-cerebral-ischemic-post-conditioning-a-review
#10
REVIEW
Zhixing Li, Hanlin Chen, Jinglei Lv, Renliang Zhao
Ischemic stroke is a serious cerebrovascular disease that leads to death and/or severe disability, and extensive research has been directed in search of appropriate treatment measures. One such potential treatment is the use of cerebral ischemic post-conditioning (IPostC), and its neuroprotective effects and controllability have been widely confirmed and validated. Numerous studies have indicated that cerebral IPostC can suppress the inflammatory reaction in ischemia reperfusion injury, improve cerebral circulation, reduce infarct volume, and promote both neurogenesis and angiogenesis...
March 8, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28280002/n-acetylcysteine-accelerates-amputation-stump-healing-in-the-setting-of-diabetes
#11
Mohamed A Zayed, Xiachao Wei, Kyoung-Mi Park, Larisa Belaygorod, Uzma Naim, Joseph Harvey, Li Yin, Kendall Blumer, Clay F Semenkovich
Over 60% of lower extremity amputations are performed in patients with diabetes and peripheral arterial disease, and at least 25% require subsequent reamputation due to poor surgical site healing. The mechanisms underlying poor amputation stump healing in the setting of diabetes are not understood. N-acetylcysteine (NAC) is known to promote endothelial cell function and angiogenesis and may have therapeutic benefits in the setting of diabetes. We tested the hypothesis that NAC alters the vascular milieu to improve healing of amputation stumps in diabetes using a novel in vivo murine hindlimb ischemia-amputation model...
March 9, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28279225/allogenic-adipose-derived-stem-cell-therapy-overcomes-ischemia-induced-microvessel-rarefaction-in-the-myocardium-systems-biology-study
#12
Gemma Vilahur, Blanca Oñate, Judit Cubedo, Maria Teresa Béjar, Gemma Arderiu, Esther Peña, Laura Casaní, Manuel Gutiérrez, Antoni Capdevila, Guillem Pons-Lladó, Francesc Carreras, Alberto Hidalgo, Lina Badimon
BACKGROUND: Myocardial microvascular loss after myocardial infarction (MI) remains a therapeutic challenge. Autologous stem cell therapy was considered as an alternative; however, it has shown modest benefits due to the impairing effects of cardiovascular risk factors on stem cells. Allogenic adipose-derived stem cells (ASCs) may overcome such limitations, and because of their low immunogenicity and paracrine potential may be good candidates for cell therapy. In the present study we investigated the effects of allogenic ASCs and their released products on cardiac rarefaction post MI...
March 9, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28266625/inhibition-of-phd3-by-salidroside-promotes-neovascularization-through-cell-cell-communications-mediated-by-muscle-secreted-angiogenic-factors
#13
Jing Zhang, Vivi Kasim, Yu-Dan Xie, Can Huang, Julita Sisjayawan, Agnes Dwi Ariyanti, Xue-Song Yan, Xiao-Yan Wu, Cai-Ping Liu, Li Yang, Makoto Miyagishi, Shou-Rong Wu
Therapeutic angiogenesis has been considered as a potential strategy for treating peripheral artery diseases including hind-limb ischemia (HLI); however, no effective drug-based treatment is currently available. Here we showed that intramuscular administration of salidroside, an active compound of Chinese herb Rhodiola, could robustly enhance blood perfusion recovery by promoting neovascularization in HLI mice. We revealed that salidroside promoted skeletal muscle cell migration and paracrine function through inhibiting the transcriptional level of prolyl-hydroxylase domain 3 (PHD3) without affecting PHD1 and PHD2...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28261920/remote-physiological-ischemic-training-promotes-coronary-angiogenesis-via-molecular-and-cellular-mobilization-after-myocardial-ischemia
#14
Yu Zheng, Mingyue Xiao, Ling Li, Jianan Li, Jan D Reinhardt, Xiao Lu
AIM: This study was designed to explore the mechanism of physiological ischemic training (PIT) on remote limbs, with a special focus on the potential role of endothelial progenitor cells (EPCs), vascular endothelial growth factor (VEGF) and nitric oxide (NO) in local ischemic myocardium. METHOD: MI rabbit models were randomly assigned to sham-operated group (SO), training only group (TO), myocardial ischemia group (MI), PIT group, VEGF inhibitor group (VEGF-), NO inhibitor group (NO-), VEGF and NO inhibitor group (VEGF-/NO-), and EPC inhibitor group (EPC-)...
March 6, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28259568/chloroquine-improves-the-response-to-ischemic-muscle-injury-and-increases-hmgb1-after-arterial-ligation
#15
Jun Xu, Xiangdong Cui, Jiehua Li, Panagiotis Koutakis, Iraklis Pipinos, Edith Tzeng, Alex Chen, Ulka Sachdev
OBJECTIVE: We have previously shown that exogenous administration of the nuclear protein high mobility group box 1 (HMGB1) improves angiogenesis after tissue ischemia. Antagonizing HMGB1 prolongs muscle necrosis and deters regeneration. In this study, we evaluated HMGB1 expression in peripheral arterial disease (PAD) and the mechanisms that promote its release in a murine model of hindlimb ischemia. Specifically, we investigated how chloroquine (CQ), a commonly employed disease-modifying antirheumatic drug, promotes HMGB1 release from muscle...
March 1, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28258568/aquaporins-in-cardiovascular-system
#16
Lu Tie, Di Wang, Yundi Shi, Xuejun Li
Recent studies have shown that some aquaporins (AQPs ), including AQP1, AQP4, AQP7 and AQP9, are expressed in endothelial cells, vascular smooth muscle cells and heart of cardiovascular system. These AQPs are involved in the cardiovascular function and in pathological process of related diseases, such as cerebral ischemia , congestion heart failure , hypertension and angiogenesis. Therefore, it is important to understand the accurate association between AQPs and cardiovascular system, which may provide novel approaches to prevent and treat related diseases...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28255275/exosomes-secreted-from-human-induced-pluripotent-stem-cell-derived-mesenchymal-stem-cells-prevent-osteonecrosis-of-the-femoral-head-by-promoting-angiogenesis
#17
Xiaolin Liu, Qing Li, Xin Niu, Bin Hu, Shengbao Chen, Wenqi Song, Jian Ding, Changqing Zhang, Yang Wang
Background: Local ischemia is the main pathological performance in osteonecrosis of the femoral head (ONFH). There is currently no effective therapy to promote angiogenesis in the femoral head. Recent studies revealed that exosomes secreted by induced pluripotent stem cell-derived mesenchymal stem cells (iPS-MSC-Exos) have great therapeutic potential in ischemic tissues, but whether they could promote angiogenesis in ONFH has not been reported, and little is known regarding the underlying mechanism. Methods: iPS-MSC-Exos were intravenously injected to a steroid-induced rat osteonecrosis model...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/28254819/mir-15b-5p-regulates-collateral-artery-formation-by-targeting-akt3-protein-kinase-b-3
#18
Ling-Ping Zhu, Ji-Peng Zhou, Jia-Xiong Zhang, Jun-Yao Wang, Zhen-Yu Wang, Miao Pan, Ling-Fang Li, Chuan-Chang Li, Kang-Kai Wang, Yong-Ping Bai, Guo-Gang Zhang
OBJECTIVE: To identify circulating microRNAs that are differentially expressed in severe coronary heart disease with well or poorly developed collateral arteries and to investigate their mechanisms of action in vivo and in vitro. APPROACH AND RESULTS: In our study, we identified a circulating microRNA, miR-15b-5p, with low expression that, nevertheless, characterized patients with sufficient coronary collateral artery function. Moreover, in murine hindlimb ischemia model, in situ hybridization identified that miR-15b-5p was specifically expressed in vascular endothelial cells of adductors in sham group and was remarkably downregulated after femoral artery ligation...
March 2, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28244825/therapeutic-potential-of-adipose-derived-stem-cells-and-macrophages-for-ischemic-skeletal-muscle-repair
#19
Viktoriya Rybalko, Pei-Ling Hsieh, Laura M Ricles, Eunna Chung, Roger P Farrar, Laura J Suggs
AIM: Progressive ischemia due to peripheral artery disease causes muscle damage and reduced strength of the lower extremities. Autologous cell therapy is an attractive treatment to restore perfusion and improve muscle function. Adipose-derived stem cells (ASCs) have therapeutic potential in tissue repair, including polarizing effects on macrophages (MPs). MATERIALS & METHODS: Co-culture systems of ASCs and MPs were analyzed for gene and protein expression modifications in ASC-conditioned MPs...
March 2017: Regenerative Medicine
https://www.readbyqxmd.com/read/28243607/treatment-with-sildenafil-and-donepezil-improves-angiogenesis-in-experimentally-induced-critical-limb-ischemia
#20
Ioana M Constantinescu, Pompei Bolfa, Dan Constantinescu, Aurel I Mironiuc, Claudia D Gherman
Objectives. In this study, we aimed to demonstrate the role of sildenafil (an antagonist of phosphodiesterase type 5 (PDE-5)) and donepezil (a specific and reversible inhibitor of acetylcholinesterase (Ach)) in increasing ischemia-induced angiogenesis. Method. Critical limb ischemia was induced by ligation of the common femoral artery followed by ligation of the common iliac artery. The operated animals were divided into 3 groups: receiving sildenafil, receiving donepezil, and surgery alone; the contralateral lower limb was used as a negative control...
2017: BioMed Research International
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