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Ischemia angiogenesis

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https://www.readbyqxmd.com/read/28527041/mechanisms-of-acupuncture-therapy-for-cerebral-ischemia-an-evidence-based-review-of-clinical-and-animal-studies-on-cerebral-ischemia
#1
REVIEW
Wen Zhu, Yang Ye, Yi Liu, Xue-Rui Wang, Guang-Xia Shi, Shuai Zhang, Cun-Zhi Liu
Ischemic stroke is a major cause of mortality and disability worldwide. As a part of Traditional Chinese Medicine (TCM), acupuncture has been shown to be effective in promoting recovery after stroke. In this article, we review the clinical and experimental studies that demonstrated the mechanisms of acupuncture treatment for cerebral ischemia. Clinical studies indicated that acupuncture activated relevant brain regions, modulated cerebral blood flow and related molecules in stroke patients. Evidence from laboratory indicated that acupuncture regulates cerebral blood flow and metabolism after the interrupt of blood supply...
May 19, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/28505880/redox-regulation-of-ischemic-limb-neovascularization-what-we-have-learned-from-animal-studies
#2
REVIEW
Reiko Matsui, Yosuke Watanabe, Colin E Murdoch
Mouse hindlimb ischemia has been widely used as a model to study peripheral artery disease. Genetic modulation of the enzymatic source of oxidants or components of the antioxidant system reveal that physiological levels of oxidants are essential to promote the process of arteriogenesis and angiogenesis after femoral artery occlusion, although mice with diabetes or atherosclerosis may have higher deleterious levels of oxidants. Therefore, fine control of oxidants is required to stimulate vascularization in the limb muscle...
May 4, 2017: Redox Biology
https://www.readbyqxmd.com/read/28499457/preconditioning-of-bone-marrow-derived-mesenchymal-stromal-cells-by-tetramethylpyrazine-enhances-cell-migration-and-improves-functional-recovery-after-focal-cerebral-ischemia-in-rats
#3
Lin Li, Lisheng Chu, Yan Fang, Yan Yang, Tiebing Qu, Jianping Zhang, Yuanjun Yin, Jingjing Gu
BACKGROUND: Transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) is one of the new therapeutic strategies for treating ischemic stroke. However, the relatively poor migratory capacity of BMSCs toward infarcted regions limited the therapeutic potential of this approach. Pharmacological preconditioning can increase the expression of CXC chemokine receptor 4 (CXCR4) in BMSCs and enhance cell migration toward the injury site. In the present study, we investigated whether tetramethylpyrazine (TMP) preconditioning could enhance BMSCs migration to the ischemic brain and improve functional recovery through upregulating CXCR4 expression...
May 12, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28488337/affinity-immobilization-of-vegf-on-laminin-porous-sponge-enhances-angiogenesis-in-the-ischemic-brain
#4
Mio Oshikawa, Kei Okada, Naoko Kaneko, Kazunobu Sawamoto, Itsuki Ajioka
Ischemic brain stroke is caused by blood flow interruption, leading to focal ischemia, neuron death, and motor, sensory, and/or cognitive dysfunctions. Angiogenesis, neovascularization from existing blood vessel, is essential for tissue growth and repair. Proangiogenic therapy for stroke is promising for preventing excess neuron death and improving functional recovery. Vascular endothelial growth factor (VEGF) is a critical factor for angiogenesis by promoting the proliferation, the survival, and the migration of endothelial cells...
May 10, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28488306/physician-initiated-first-in-human-clinical-study-using-a-novel-angiogenic-peptide-ag30-5c-for-patients-with-severe-limb-ulcers
#5
Hironori Nakagami, Toshifumi Yamaoka, Misa Hayashi, Atsushi Tanemura, Yasushi Takeya, Hitomi Kurinami, Ken Sugimoto, Ayumi Nakamura, Kazunori Tomono, Katsuto Tamai, Ichiro Katayama, Hiromi Rakugi, Yasufumi Kaneda
AIM: In patients with diabetes or ischemia, angiogenesis and infection control are required for chronic leg ulcers, which substantially impair patients' quality of life. We developed a novel functional peptide, named AG30/5C, with angiogenic and anti-microbial properties. Treatment with AG30/5C significantly accelerated the wound healing of full-thickness defects in mice. To evaluate the safety of AG30/5C in the treatment of leg ulcers, a physician-initiated clinical study was carried out...
May 10, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28487988/delayed-administration-of-guanosine-improves-long%C3%A2-term-functional-recovery-and-enhances-neurogenesis-and-angiogenesis-in-a-mouse-model-of-photothrombotic-stroke
#6
Gang Deng, Zhandong Qiu, Dayong Li, Yu Fang, Suming Zhang
Guanosine (GUO) is neuroprotective when administered acutely for the treatment of cerebral ischemia. The aim of the present study was to investigate whether delayed administration of GUO improved long‑term functional recovery following stroke, as well as to explore the potential underlying mechanisms. GUO (8 mg/kg) or a vehicle was administered intraperitoneally for 7 consecutive days beginning 24 h prior to photothrombosis‑induced stroke in male C57/B6J mice. Behaviour tests were performed at days 1, 3, 7, 14 and 28 post‑stroke...
June 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28487975/decreased-phosphorylation-of-pdgfr-%C3%AE-impairs-the-angiogenic-potential-of-expanded-endothelial-progenitor-cells-via-the-inhibition-of-pi3k-akt-signaling
#7
Haiyuan Lu, Hua Mei, Fan Wang, Qian Zhao, Siqi Wang, Lvjun Liu, Lamei Cheng
Human umbilical cord blood-derived endothelial progenitor cells (EPCs) have been proven to contribute to post-natal angiogenesis, and have been applied in various models of ischemia. However, to date, to the best of our knowledge, there is no available data on the angiogenic properties of EPCs during the process of in vitro expansion. In this study, we expanded EPCs to obtain cells at different passages, and analyzed their cellular properties and angiogenic ability. In the process of expansion, no changes were observed in cell cobblestone-like morphology, apoptotic rate and telomere length...
June 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28474327/pet-imaging-in-heart-failure-the-role-of-new-tracers
#8
REVIEW
Antti Saraste, Juhani Knuuti
Positron emission tomography (PET) myocardial perfusion imaging is being increasingly used for the detection of coronary artery disease. In the presence of significant left ventricle dysfunction, the assessment of myocardial ischemia and viability by PET plays a role in the identification of patients who may benefit from revascularization. In addition to these, new PET tracers may play a role in the assessment of underlying pathophysiology and therapeutic options in heart failure. Studies have shown the ability of sympathetic innervation imaging to assess the risk of cardiac death, arrhythmia, and disease progression...
May 5, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28473248/endothelial-deletion-of-mtorc1-protects-against-hindlimb-ischemia-in-diabetic-mice-via-activation-of-autophagy-attenuation-of-oxidative-stress-and-alleviation-of-inflammation
#9
Wensi Fan, Dong Han, Zhongchan Sun, Sai Ma, Lei Gao, Jiangwei Chen, Xiang Li, Xiujuan Li, Miaomiao Fan, Congye Li, Dahai Hu, Yabin Wang, Feng Cao
Peripheral arterial disease (PAD) complicated with diabetes mellitus (DM) still remains a thorny issue due to lack of effective strategies. Our previous study has demonstrated that inhibition of mTORC1 protected adipose-derived stromal cells from hindlimb ischemic injury in PAD mice. However, whether inhibition of mTORC1 could protect against PAD in diabetes mellitus and the underlying mechanisms remained elusive. In this study, we employed endothelial-specific raptor (an essential component of the mTORC1 signaling complex) knockout (KO) mice (Tie2-mTORC1(ko)) to investigate whether and how mTORC1 downregulation could alleviate hindlimb ischemic injury in diabetic mice...
May 1, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28469805/therapeutic-ultrasound-protects-huvecs-from-ischemia-hypoxia-induced-apoptosis-via-the-pi3k-akt-pathway
#10
Jing-Juan Huang, Yi-Qin Shi, Rui-Lin Li, An Hu, Zhao-Yang Lu, Liang Weng, Yi-Peng Han, Shen-Qi Wang, Lan Zhang, Chang-Ning Hao, Jun-Li Duan
Background: Previous studies have demonstrated that therapeutic ultrasound (TUS) ameliorates angiogenesis on ischemic hind limb animals and also promotes human umbilical vein endothelial cells (HUVECs) tube formation. Apoptosis plays a key role in post-ischemic angiogenesis pathogenesis. However, the mechanisms underlying the anti-apoptotic effects of TUS are not clear. Therefore we put forward the hypothesis that TUS might promote angiogenesis during ischemia/hypoxia (I/H) by decreasing apoptosis. Methods: We investigated the cytoprotective role of TUS and the underlying mechanisms in I/H-induced HUVEC apoptosis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28460604/the-15-lo-1-15-hete-system-promotes-angiogenesis-by-upregulating-vegf-in-ischemic-brains
#11
Li Chen, Yan-Mei Zhu, Yu-Nong Li, Peng-Yan Li, Di Wang, Yu Liu, You-Yang Qu, Da-Ling Zhu, Yu-Lan Zhu
OBJECTIVES: Angiogenesis promotes neurobehavioral recovery after cerebral ischemic stroke. 15(S)-hydroxyeicosatetraenoic acid (15-HETE) is one of the major metabolites of arachidonic acid by 15-lipoxygenase (15-LO) and stimulates the production of vascular endothelial growth factor (VEGF), thus, inducing autocrine-mediated angiogenesis. The present study aimed to investigate the role of 15-LO/15-HETE system on VEGF expression and angiogenesis in brain ischemia. METHODS: Rat cerebral arterial vascular endothelial cells were used to set up a cell injury model of oxygen-glucose deprivation and reoxygenation (OGD/R), mimicking a condition of brain ischemia...
May 1, 2017: Neurological Research
https://www.readbyqxmd.com/read/28459804/transplantation-of-hgf-gene-engineered-skeletal-myoblasts-improve-infarction-recovery-in-a-rat-myocardial-ischemia-model
#12
Shu-Ling Rong, Xiao-Lin Wang, Cui-Ying Zhang, Zhuo-Hui Song, Lu-Hua Cui, Xiao-Feng He, Xu-Jiong Li, Hui-Jin Du, Bao Li
BACKGROUND: Skeletal myoblast transplantation seems a promising approach for the repair of myocardial infarction (MI). However, the low engraftment efficacy and impaired angiogenic ability limit the clinical efficiency of the myoblasts. Gene engineering with angiogenic growth factors promotes angiogenesis and enhances engraftment of transplanted skeletal myoblasts, leading to improved infarction recovery in myocardial ischemia. The present study evaluated the therapeutic effects of hepatocyte growth factor (HGF) gene-engineered skeletal myoblasts on tissue regeneration and restoration of heart function in a rat MI model...
2017: PloS One
https://www.readbyqxmd.com/read/28450935/microrna-138-inhibits-hypoxia-induced-proliferation-of-endothelial-progenitor-cells-via-inhibition-of-hif-1%C3%AE-mediated-mapk-and-akt-signaling
#13
Wei Zhou, Weimin Zhou, Qingzhong Zeng, Jixin Xiong
Endothelial progenitor cells (EPCs) participate in angiogenesis by differentiating into endothelial cells (ECs) and may be developed to treat ischemia/reperfusion injury. MicroRNAs (miRs) are a type of non-coding RNA that are 18-25 nucleotides in length and serve a role in angiogenesis. It has been demonstrated that miR-138 regulates hypoxia-induced EC dysfunction. However, to the best of our knowledge, the exact role of miR-138 in the regulation of hypoxia-induced EPCs has not previously been reported. In the present study, data collected from an MTT assay indicated that hypoxia treatment enhanced EPC proliferation, which was accompanied by an upregulation of hypoxia-inducible factor 1α (HIF-1α) expression...
March 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28448515/chronic-cocaine-induces-hif-vegf-pathway-activation-along-with-angiogenesis-in-the-brain
#14
Wei Yin, Kevin Clare, Qiujia Zhang, Nora D Volkow, Congwu Du
Cocaine induces vasoconstriction in cerebral vessels, which with repeated use can result in transient ischemic attacks and cerebral strokes. However, the neuroadaptations that follow cocaine's vasoconstricting effects are not well understood. Here, we investigated the effects of chronic cocaine exposure (2 and 4 weeks) on markers of vascular function and morphology in the rat brain. For this purpose we measured nitric oxide (NO) concentration in plasma, brain neuronal nitric oxide synthase (nNOS or NOS1), HIF-1α, and VEGF expression in different brain regions, i...
2017: PloS One
https://www.readbyqxmd.com/read/28444128/low-dose-ionizing-radiation-induces-therapeutic-neovascularization-in-a-pre-clinical-model-of-hindlimb-ischemia
#15
Augusto Ministro, Paula de Oliveira, Raquel J Nunes, André Dos Santos Rocha, Adriana Correia, Tânia Carvalho, José Rino, Pedro Faísca, Jorg D Becker, João Goyri-O'Neill, Filomena Pina, Esmeralda Poli, Bruno Silva-Santos, Fausto Pinto, Marc Mareel, Karine Serre, Susana Constantino Rosa Santos
Aims: We have previously shown that low-dose ionizing radiation (LDIR) induces angiogenesis but there is no evidence that it induces neovascularization in the setting of peripheral arterial disease. Here, we investigated the use of LDIR as an innovative and non-invasive strategy to stimulate therapeutic neovascularization using a model of experimentally induced hindlimb ischemia (HLI). Methods and results: After surgical induction of unilateral HLI, both hindlimbs of female C57BL/6 mice were sham-irradiated or irradiated with four daily fractions of 0...
June 1, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28424975/etv-2-activated-proliferation-of-endothelial-cells-and-attenuated-acute-hindlimb-ischemia-in-mice
#16
Phuc Van Pham, Ngoc Bich Vu, Hoa Trong Nguyen, Thuy Thi-Thanh Dao, Ha Thi-Ngan Le, Lan Thi Phi, Oanh Thi-Kieu Nguyen, Ngoc Kim Phan
Ischemia is the reduction of blood flow to tissues by injury of blood vessels. Depending on the sites of tissues and grade of ischemia, ischemia can cause many serious complications. This study aimed to evaluate the effects of the E-twenty six (ETS) factor Ets variant 2 (ETV2) gene expression in angiogenesis and the effect of ETV2 gene therapy in a mouse model of hindlimb ischemia. The role of ETV2 on endothelial cell proliferation was evaluated in vitro. Knockdown of ETV2 expression was done using short hairpin RNA (shRNA) lentiviral viral particles...
April 19, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28424623/notch-signaling-in-ischemic-damage-and-fibrosis-evidence-and-clues-from-the-heart
#17
REVIEW
Silvia Nistri, Chiara Sassoli, Daniele Bani
Notch signaling is a major intercellular coordination mechanism highly conserved throughout evolution. In vertebrates, Notch signaling is physiologically involved in embryo development, including mesenchymal cell commitment, formation of heart tissues and angiogenesis. In post-natal life, Notch signaling is maintained as a key mechanism of cell-cell communication and its dysregulations have been found in pathological conditions such as ischemic and fibrotic diseases. In the heart, Notch takes part in the protective response to ischemia, being involved in pre- and post-conditioning, reduction of reperfusion-induced oxidative stress and myocardial damage, and cardiomyogenesis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28417947/pro-angiogenic-effects-of-low-dose-ethoxidine-in-a-murine-model-of-ischemic-hindlimb-correlation-between-ethoxidine-levels-and-increased-activation-of-the-nitric-oxide-pathway
#18
Nicolas Clere, Kim Hung Thien To, Samuel Legeay, Samuel Bertrand, Jean Jacques Helesbeux, Olivier Duval, Sébastien Faure
Ethoxidine, a benzo[c]phenanthridine derivative, has been identified as a potent inhibitor of topoisomerase I in cancer cell lines. Our group has reported paradoxical properties of ethoxidine in cellular processes leading to angiogenesis on endothelial cells. Because low concentration ethoxidine is able to favor angiogenesis, the present study aimed to investigate the ability of 10(-9) M ethoxidine to modulate neovascularization in a model of mouse hindlimb ischemia. After inducing unilateral hindlimb ischemia, mice were treated for 21 days with glucose 5% or with ethoxidine, to reach plasma concentrations equivalent to 10(-9) M...
April 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28407626/exogenous-mirna-146a-enhances-the-therapeutic-efficacy-of-human-mesenchymal-stem-cells-by-increasing-vascular-endothelial-growth-factor-secretion-in-the-ischemia-reperfusion-injured-heart
#19
Hyang-Hee Seo, Se-Yeon Lee, Chang Youn Lee, Ran Kim, Pilseog Kim, Sekyung Oh, Hojin Lee, Min Young Lee, Jongmin Kim, Lark Kyun Kim, Ki-Chul Hwang, Woochul Chang
Adult stem cells have been studied as a promising therapeutic modality for the functional restoration of the damaged heart. In the present study, a strategy for enhancing the angiogenic efficacy of human mesenchymal stem cells (hMSCs) using micro-RNA was examined. We investigated whether micro-RNA-146a (miR-146a) influences the secretion of vascular endothelial growth factor (VEGF) and angiogenesis of MSCs. Our data indicated that miR-146a-transfected hMSCs (hMSCmiR-146a) decreased the expression of neurofibromin 2, an inhibitor of p21-activated kinase-1 (PAK1)...
2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28402976/apelin-13-protects-against-ischemic-blood-brain-barrier-damage-through-the-effects-of-aquaporin-4
#20
Heling Chu, Xiaobo Yang, Chuyi Huang, Zidan Gao, Yuping Tang, Qiang Dong
BACKGROUND: Apelin-13 has been found to have protective effects on many neurological diseases, including cerebral ischemia. However, whether Apelin-13 acts on blood-brain barrier (BBB) disruption following cerebral ischemia is largely unknown. Aquaporin-4 (AQP4) has a close link with BBB due to the high concentration in astrocyte foot processes and regulation of astrocytes function. Here, we aimed to test Apelin-13's effects on ischemic BBB injury and examine whether the effects were dependent on AQP4...
April 13, 2017: Cerebrovascular Diseases
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