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https://www.readbyqxmd.com/read/29456198/a-modified-single-loop-reconstruction-after-pancreaticoduodenectomy-reduces-severity-of-postoperative-pancreatic-fistula-in-high-risk-patients
#1
Ilgar Aghalarov, Torsten Herzog, Waldemar Uhl, Orlin Belyaev
BACKGROUND: Double-loop (DL) reconstruction after pancreaticoduodenectomy (PD), diverting pancreatic from biliary secretions, has been reported to reduce rates and severity of postoperative pancreatic fistula (POPF) compared to single loop (SL) reconstruction at the price of prolonged operative duration. This study investigated the feasibility of a new reconstruction method combining the advantages of DL with the simplicity of SL in patients with high-risk pancreas. METHODS: A modified single-loop (mSL) reconstruction was used in patients undergoing PD with a soft pancreatic remnant and a pancreatic duct smaller than 3 mm (n = 50)...
February 15, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29441297/branch-duct-type-intraductal-papillary-mucinous-neoplasm-presenting-as-paraneoplastic-small-plaque-para-psoriasis
#2
Cyriac A Philips, Philip Augustine, Lijesh Kumar, George Joseph, Pushpa Mahadevan
To present and discuss a novel association between branch duct-type intraductal papillary mucinous neoplasm and paraneoplastic parapsoriasis. We present the case of a middle-aged male presenting with skin lesions that were suggestive of parapsoriasis, resistant to treatment, and in whom a diagnosis of branch-type intraductal papillary mucinous neoplasm of the pancreas was eventually made. A curative Whipple's surgery led to complete resolution of the skin lesions within 3 weeks. Paraneoplastic parapsoriasis in association with intraductal papillary mucinous pancreatic neoplasm has never been reported before...
January 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29439708/possible-relationship-between-fibrosis-of-igg4-related-thymitis-and-the-profibrotic-cytokines-transforming-growth-factor-beta-1-interleukin-1-beta-and-interferon-gamma-a-case-report
#3
Atsuko Masunaga, Fumihiro Ishibashi, Eitetsu Koh, Takashi Oide, Yasuo Sekine, Kenzo Hiroshima
BACKGROUND: IgG4-related disease often forms a mass and the affected lesion is clinically removed because the mass cannot be differentiated from a neoplasm. Affected lesions commonly occur in the pancreas, hepatobiliary tract, kidney, and retroperitoneum. However, the lesion rarely occurs in the thymus. A histological worldwide consensus of IgG4-related disease proposed that pathological diagnosis of IgG4-related disease should meet more than two of three major features: 1) dense lymphoplasmacytic infiltration with greater than 40% IgG4+/IgG+ plasma cells, 2) storiform fibrosis; and 3) obliterative phlebitis...
January 17, 2018: Diagnostic Pathology
https://www.readbyqxmd.com/read/29435751/impact-of-anatomical-position-of-the-pancreas-on-postoperative-complications-and-drain-amylase-concentrations-after-laparoscopic-distal-gastrectomy-for-gastric-cancer
#4
Koshi Kumagai, Naoki Hiki, Souya Nunobe, Satoshi Kamiya, Masahiro Tsujiura, Satoshi Ida, Manabu Ohashi, Toshiharu Yamaguchi, Takeshi Sano
BACKGROUND: Laparoscopic surgery for gastric cancer requires traction or compression of the pancreas, with the extent depending on the anatomical position of the pancreas. This study investigated the impact of the position of the pancreas on postoperative complications and drain amylase concentrations after laparoscopic distal gastrectomy (LDG). METHODS: Gastric cancer patients who underwent LDG were assessed retrospectively. The following anatomical parameters were measured retrospectively in preoperative computed tomography sagittal projections: the length of the vertical line between the pancreas and the aorta (P-A length), representing the height of the slope looking down the celiac artery from the top of the pancreas, and the angle between a line drawn from the upper border of the pancreas to the root of the celiac artery and the aorta (UP-CA angle), representing the steepness of the slope...
February 12, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29434957/experience-based-surgical-approach-to-pancreatic-mucinous-cystic-neoplasms-with-ovarian-type-stroma
#5
Chang Moo Kang, Akira Matsushita, Ho Kyoung Hwang, Yoko Matsuda, Hyunki Kim, Yoshiharu Nakamura, Woo Jung Lee
The present study aimed to elucidate the clinicopathological characteristics of resected mucinous cystic neoplasm (MCN) with ovarian-type stroma and identify a surgical approach for MCN treatment, on the basis of Republic of Korean (Yonsei University College of Medicine, Seoul, South Korea) and Japanese (Nippon Medical School, Tokyo, Japan) bi-institutional collaboration. The present study retrospectively reviewed 55 MCNs with ovarian-type stroma using pathological re-examination. Clinicopathological features and preoperative clinical parameters were evaluated to predict malignant alterations in MCNs...
February 2018: Oncology Letters
https://www.readbyqxmd.com/read/29432918/exploration-of-the-platelet-proteome-in-patients-with-early-stage-cancer
#6
Siamack Sabrkhany, Marijke J E Kuijpers, Jaco C Knol, Steven W M Olde Damink, Anne-Marie C Dingemans, Henk M Verheul, Sander R Piersma, Thang V Pham, Arjan W Griffioen, Mirjam G A Oude Egbrink, Connie R Jimenez
Platelets play an important role in tumor growth and, at the same time, platelet characteristics are affected by cancer presence. Therefore, we investigated whether the platelet proteome harbors differentially expressed proteins associated with early-stage cancer. For this proof-of-concept study, patients with early-stage lung (n = 8) or head of pancreas cancer (n = 4) were included, as were healthy sex- and age-matched controls for both subgroups. Blood samples were collected from controls and from patients before surgery...
February 9, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29428804/links-between-a-biomarker-profile-cold-ischaemic-time-and-clinical-outcome-following-simultaneous-pancreas-and-kidney-transplantation
#7
Hussein A Khambalia, M Yvonne Alexander, Mahesan Nirmalan, Ria Weston, Phillip Pemberton, Zia Moinuddin, Angela Summers, David van Dellen, Titus Augustine
In sepsis, trauma and major surgery, where an explicit physiological insult leads to a significant systemic inflammatory response, the acute evolution of biomarkers have been delineated. In these settings, Interleukin (IL) -6 and TNF-α are often the first pro-inflammatory markers to rise, stimulating production of acute phase proteins followed by peaks in anti-inflammatory markers. Patients undergoing SPKT as a result of diabetic complications already have an inflammatory phenotype as a result of uraemia and glycaemia...
February 8, 2018: Cytokine
https://www.readbyqxmd.com/read/29428110/pancreatic-parenchymal-injection-of-ethanol-and-octreotide-to-induce-focal-pancreatic-fibrosis-in-rats-strategies-to-eliminate-postoperative-pancreatic-fistula
#8
Soo Ho Lee, Tae Ho Hong
BACKGROUND: Postoperative pancreatic fistula (POPF) is more likely to occur in a soft pancreas compared to a hard pancreas in which fibrosis has progressed. There is almost no leakage at the anastomosis site or cut surface of a hard pancreas. The aim of this study was to induce localized fibrosis at the cut surface of the pancreas in a rat model. METHODS: Thirty-six rats were divided into three groups (group S: normal saline group; group E: ethanol group; and group O: octreotide group)...
February 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29428036/span-1-and-ca19-9-as-predictors-of-early-recurrence-and-lymph-node-metastasis-for-patients-with-invasive-pancreatic-cancer-after-pancreatectomy
#9
Tetsunosuke Shimizu, Mitsuhiro Asakuma, Atsushi Tomioka, Yoshihiro Inoue, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
Because pancreatic cancer is a disease with a dismal prognosis due to the high rate of early recurrence even after curative surgery, selecting the most effective treatment in an individual requires preoperative assessment of the tumor characteristics, including the potential for early recurrence. The study cohort included 84 patients undergoing surgical resection of pancreatic cancer. Univariate and multivariate analyses were conducted to identify the risk factors for early recurrence within six months after curative resection...
January 1, 2018: American Surgeon
https://www.readbyqxmd.com/read/29425780/risk-of-pancreatic-cancer-in-patients-with-pancreatic-cysts-and-family-history-of-pancreatic-cancer
#10
Saurabh S Mukewar, Ayush Sharma, Nissy Phillip, Ridhi Gupta, Anupama Aryal-Khanal, Nicolo de Pretis, Vincent Anani, Felicity T Enders, Joseph J Larson, Naoki Takahashi, Michael J Levy, Mark Topazian, Randall K Pearson, Santhi S Vege, Suresh T Chari
BACKGROUND & AIMS: A diagnosis of pancreatic cancer in a first-degree relative increases an individuals' risk of this cancer. However, it is not clear whether this cancer risk increases in individuals with pancreatic cystic lesions who have a first-degree relative with pancreatic cancer. The Fukuoka criteria are used to estimate risk of pancreatic cancer for patients with pancreatic cystic lesions: individuals with cysts with high risk or worrisome features (Fukuoka positive) have a higher risk of pancreatic cancer than individuals without these features (Fukuoka negative)...
February 6, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29423821/the-emerging-role-of-stereotactic-radiotherapy-in-gastrointestinal-malignancies-a-review-of-the-literature-and-analysis-from-the-irish-perspective
#11
Siobhra O'Sullivan, Daniel N Cagney
Primary and secondary malignancies of the liver and pancreas result in significant morbidity and mortality, with increasing incidence and increasing demands on health services worldwide. Surgery is the only curative single modality of treatment and remains the gold standard. Unfortunately, up to 80% of the patients present with unresectable disease, and so, alternative efficacious local and systemic treatments are needed. Technologic advances in radiotherapy over recent decades have meant that precision high-dose treatment with stereotactic body radiotherapy (SBRT) has emerged as a viable cost-effective outpatient-based treatment in the management of these difficult to treat abdominal malignancies...
February 8, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29423155/successful-surgical-treatment-for-huge-retroperitoneal-liposarcoma-involving-the-pancreas-right-kidney-abdominal-aorta-and-inferior-vena-cava
#12
Mariko Tanaka, Toshiyasu Kawahara, Takahiro Nishikoshi, Masahiro Hagiwara, Koji Imai, Kimiharu Hasegawa, Atsuhiro Koya, Naoto Matsuno, Hidehiro Takei, Nobuyoshi Azuma, Hiroyuki Furukawa
Retroperitoneal liposarcoma is a rare neoplasm that often involves other organs and major blood vessels. Complete surgical resection with negative margins is the only potential curative treatment. Here, we report the case of a patient with a large retroperitoneum liposarcoma that was removed by resection of the descending abdominal aorta and infrahepatic inferior vena cava, right nephrectomy and pancreatoduodenectomy following creation of an extra anatomical femoro-femoral crossover bypass after left axillo-left femoral bypass...
November 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29421807/the-clinical-management-of-main-duct-intraductal-papillary-mucinous-neoplasm-of-the-pancreas
#13
Chiara Dal Borgo, Giampaolo Perri, Alex Borin, Giovanni Marchegiani, Roberto Salvia, Claudio Bassi
BACKGROUND: Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas comprise a heterogeneous group of intraductal mucin-producing neoplasms representing a typical adenoma-to-carcinoma sequence. The involvement of the main pancreatic duct (MPD) is a feature of paramount importance, directly related to a more aggressive biology and a higher malignancy rate. METHOD: We review and discuss the clinical management of IPMNs with a MPD involvement, recalling the different consensus guidelines and addressing recent controversies in literature, presenting the current clinical practice in Verona Pancreas Institute...
February 8, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29419911/normoglycemic-glucagonoma-syndrome-associated-with-necrolytic-migratory-erythema
#14
R Feldmann, S Wahl, A Steiner
Glucagonoma is an extremely rare tumor of the pancreatic alpha-cells. Its estimated annual incidence is 1 case per 20 million individuals. Necrolytic migratory erythema (NME) is the hallmark clinical sign. We report a patient with normoglycemic glucagonoma and NME. A 44-year-old male patient presented with a 4-year history of unexplained exanthema and unintentional weight loss. Skin examination revealed a mildly pruritic rash on the trunc, the extremities and the face (fig 1). One found erythematous polycyclic migratory lesions with scaling and crusting margins and central resolution...
February 8, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29414805/a-novel-approach-for-hepatic-arterial-reconstruction-after-total-pancreatectomy-with-common-hepatic-artery-resection-using-inferior-phrenic-artery
#15
Takatsugu Matsumoto, Keiichi Kubota, Taku Aoki, Takayuki Shimizu, Shozo Mori, Masato Kato, Hirotaka Asato
BACKGROUND/AIMS: Because of the anatomical characteristics, pancreatic cancers (PC) can easily invade to visceral vessels such as celiac artery, superior mesenteric artery, common hepatic artery (CHA) and portal vein, which makes curative resection difficult. In this study, we report an R0 resection for locally advanced PC by total pancreatectomy, combined resection of CHA, and reconstruction of hepatic artery using autologous left inferior phrenic artery (IPA). METHODS: A 47-year-old woman with complaints of low back pain was referred to our department...
February 7, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29412465/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-pseudomyxoma-peritonei-of-appendicular-and-extra-appendicular-origin
#16
J-B Delhorme, F Severac, G Averous, O Glehen, G Passot, N Bakrin, F Marchal, M Pocard, R Lo Dico, C Eveno, S Carrere, O Sgarbura, F Quenet, G Ferron, D Goéré, C Brigand
BACKGROUND: The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra-appendicular PMP (EA-PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: All patients treated for PMP with CCRS and HIPEC between 1994 and 2016 were selected retrospectively from a French multicentre database...
February 7, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29408875/semi-automated-digital-measurement-as-the-method-of-choice-for-beta-cell-mass-analysis
#17
Violette Coppens, Gunter Leuckx, Yves Heremans, Willem Staels, Yannick Verdonck, Luc Baeyens, Nico De Leu, Harry Heimberg
Pancreas injury by partial duct ligation (PDL) activates beta cell differentiation and proliferation in adult mouse pancreas but remains controversial regarding the anticipated increase in beta cell volume. Several reports unable to show beta cell volume augmentation in PDL pancreas used automated digital image analysis software. We hypothesized that fully automatic beta cell morphometry without manual micrograph artifact remediation introduces bias and therefore might be responsible for reported discrepancies and controversy...
2018: PloS One
https://www.readbyqxmd.com/read/29404916/a-case-of-pancreatic-av-malformation-in-an-elderly-man
#18
Vipin Gupta, Saurabh Kedia, Ujjwal Sonika, Kumble Seetharama Madhusudhan, Sujoy Pal, Pramod Garg
A 60-year-old man presented with recurrent abdominal pain and weight loss for 6 months. Abdominal imaging showed a large vascular lesion in the head and neck of pancreas suggestive of arteriovenous malformation (AV malformation). Endoscopic ultrasound was done which showed features of AV malformation with no evidence of pancreatic malignancy. Surgery was planned for definitive treatment of malformation. Digital subtraction angiography with angioembolization was done prior to surgery to reduce vascularity of the lesion...
February 5, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29401172/the-2012-international-consensus-guidelines-of-intraductal-papillary-mucinous-neoplasms-of-the-pancreas-fukuoka-criteria-predict-the-malignant-potential-even-in-actual-clinical-situations
#19
Yukiyasu Okamura, Shusei Sano, Teiichi Sugiura, Takaaki Ito, Yusuke Yamamoto, Ryo Ashida, Hirotoshi Ishiwatari, Hiroyuki Matsubayashi, Keiko Sasaki, Katsuhiko Uesaka
OBJECTIVES: The aim of the present study was to validate the use of the 2012 International Consensus Guidelines for intraductal papillary mucinous neoplasm (IPMN) (Fukuoka criteria) in patients without findings of obstructive jaundice and/or an enhanced solid component. METHODS: This retrospective study included patients who underwent pancreatectomy for IPMN between October 2002 and September 2016. The sensitivity, specificity, and positive and negative predictive values for malignancy were calculated for each feature of high-risk stigmata...
March 2018: Pancreas
https://www.readbyqxmd.com/read/29401168/long-term-outcomes-of-gastroenteropancreatic-neuroendocrine-tumors
#20
Weiwei Chi, Richard R P Warner, David L Chan, Simron Singh, Eva Segelov, Jonathan Strosberg, Juan Wisnivesky, Michelle K Kim
OBJECTIVES: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare but have been increasing in incidence. Limited data on the long-term outcomes of patients with these tumors are available. METHODS: In this study, we used population-based data from the National Cancer Institute to assess long-term disease-specific survival (DSS) of patients who have undergone surgery for nonmetastatic disease. All patients with NETs of the stomach, small intestine, colon, rectum, appendix, and pancreas diagnosed between 1988 and 2009 were identified from the Surveillance, Epidemiology and End Results registry...
February 2, 2018: Pancreas
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