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JOURNAL ARTICLE
Nagomi Yonezawa, Eri Mori, Masayoshi Tei, Rumi Sekine, Monami Nagai, Yuka Tsurumoto, Hirotaka Tanaka, Nobuyoshi Otori
OBJECTIVE: Most patients with olfactory dysfunction experience stress and anxiety because of the inconvenience and changes caused by the loss of olfaction. However, psychological assessment is not performed routinely in patients with olfactory dysfunction, and the characteristics of these patients with psychological depression are unclear. METHODS: In this study, we used the Self-rating Depression Scale to evaluate the degree of depression in patients who visited our clinic with olfactory dysfunction and examine the characteristics of these patients with strong depressive tendencies...
April 8, 2024: European Archives of Oto-rhino-laryngology
#2
JOURNAL ARTICLE
Rumi Sekine, Anna Kristina Hernandez, Clara Overbeck, Marlise K Hofer, Eri Mori, Antje Hähner, Thomas Hummel
OBJECTIVES: This study aimed to determine the characteristics of patients with qualitative olfactory dysfunction (qualOD) and whether individuals with parosmia exhibit increased olfactory sensitivity to previously reported odorous triggers of parosmia. METHODS: This study included individuals aged ≥18 years, divided into quantitative OD only, parosmia, and phantosmia groups. Data collected included: clinical-demographic data, "Sniffin' Sticks" scores, questionnaires (depression scale, importance of olfaction), and information about parosmia and phantosmia...
April 5, 2024: Laryngoscope
#3
JOURNAL ARTICLE
Malgorzata Buksinska, Piotr Henryk Skarzynski, Danuta Raj-Koziak, Elzbieta Gos, Malgorzata Talarek
(1) Background: One of the possible symptoms of COVID-19 is a sudden loss of smell and taste. The main aim of the study was to evaluate the severity of post-COVID-19 olfactory dysfunction (OD). A secondary aim was to assess the relationship between OD and gustatory (taste) dysfunction (GD). Margins: 2.5 cm (1 inch) at top, bottom, right, and left. (2) Methods: The study group consisted of 81 subjects (16 men and 65 women) aged between 12 and 73 years. All of the patients presented to a center for subjective OD associated with COVID-19...
February 28, 2024: Life
#4
JOURNAL ARTICLE
Anne-Laure Hamel, Léo Delbos, Pierre-André Natella, Thomas Radulesco, Mihaela Alexandru, Emmanuel Bartaire, Sophie Bartier, Gonda Benoite, Emilie Bequignon, Laurent Castillo, Florence Canouï-Poitrine, Florent Carsuzaa, Alain Corré, André Coste, Vincent Couloigner, Clémentine Daveau, Paul De Boissieu, Guillaume De Bonnecaze, Ludovic De Gabory, Christian Debry, Simon Deraedt, Xavier Dufour, Wissame El Bakkouri, Laurent Gilain, Stéphane Hans, Charlotte Hautefort, Ruben Hermann, Roger Jankowski, Candice La Croix, Jean-Baptiste Lecanu, Olivier Malard, Justin Michel, Yann Nguyen, Jerome Nevoux, Jean-François Papon, Vincent Patron, Marine Prigent, Virginie Pruliere-Escabasse, Marion Renaud, Cécile Rumeau, Dominique Salmon, Nicolas Saroul, Elie Serrano, Christine Nhung Tran Khai, Stéphane Tringali, Eric Truy, Clair Vandersteen, Benjamin Verillaud, Raphaël Veil, Maxime Fieux
BACKGROUND: Among all studies describing COVID-19 clinical features during the first wave of the pandemic, only a few retrospective studies have assessed the correlation between olfac-tory dysfunction (OD) and the evolution of disease severity. The main aim was to assess whether OD is a predictive factor of COVID-19 severity based on the patient's medical management (outpa-tient care, standard hospital admission, and ICU admission). METHODS: A national, prospective, mul-ticenter cohort study was conducted in 20 public hospitals and a public center for COVID-19 screen-ing...
February 22, 2024: Life
#5
JOURNAL ARTICLE
Myrsini Ioakeim-Ioannidou, Juliane Daartz, Parsa Erfani, Tobias Urell, Arthur Lalonde, Julia Berv, Shannon Leahy, Barbara Fullerton, Rachel Bolton, Torunn Yock, Nancy Tarbell, Beow Yeap, Shannon M MacDonald
BACKGROUND: Unusual olfactory perception, often referred to as "phantosmia" or "cacosmia" has been reported during brain radiotherapy (RT), but is infrequent and does not typically interfere with the ability to deliver treatment. We seek to determine the rate of phantosmia for patients treated with proton craniospinal irradiation (CSI) and identify any potential clinical or treatment-related associations. METHODS: We performed a retrospective review of 127 pediatric patients treated with CSI, followed by a boost to the brain for primary brain tumors in a single institution between 2016 and 2021...
February 29, 2024: Pediatric Blood & Cancer
#6
REVIEW
Razman Arabzadeh Bahri, Fatemeh Esmaeilpur Abianeh, Maral Peisepar, Reihaneh Hadi, Fatemeh A Basti, Saba Maleki, Hanieh Radkhah
Aim: To systematically review the cases of anosmia or ageusia after receiving the coronavirus disease 2019 (COVID-19) vaccine. Methods: A systematic search was conducted in electronic databases, including Web of Science, Scopus, Embase, and PubMed, to identify any published study that evaluated the anosmia or ageusia after receiving the COVID-19 vaccine, including case reports, case series, letter to editor articles with reported cases regarding our topic, or observational studies with at least 1 eligible patient consisted with our criteria...
February 27, 2024: Ear, Nose, & Throat Journal
#7
REVIEW
Tommaso Ercoli, Caterina Francesca Bagella, Claudia Frau, Elisa Ruiu, Sabrine Othmani, Giansalvo Gusinu, Carla Masala, Leonardo Antonio Sechi, Paolo Solla, Giovanni Defazio
Olfactory dysfunction is a prevalent non-motor symptom in Parkinson's disease (PD), affecting approximately 65-90% of subjects. PD patients may also report odor perception in the absence of any external source, often referred to as olfactory hallucinations (OHs) or phantosmia. This study aims to explore the current understanding of OHs in PD and offer a comprehensive overview of their prevalence and characteristics. We conducted a systematic search of the literature published on PubMed from inception to July 2023 regarding OHs in PD, following PRISMA guidelines...
December 22, 2023: Neurology International
#8
JOURNAL ARTICLE
Feras M Alkholaiwi, Alhanouf F Altamimi, Hanan H Almalki, Fay A Almughaiseeb, Shoug S Alsubaie, Hessah S Alsayahi, Fras W Alhijli, Reema S Alobaishi, Amit Agrawal, Zuhour A Alqahtani, Fahad Z Alotaibi
OBJECTIVES: To assess the frequency of olfactory dysfunction (OD) among individuals afflicted with coronavirus disease of 2019 (COVID-19). METHODS: A comprehensive literature search was carried out across several bibliographical databases (PubMed, Scopus, Google Scholar, and Web of Science) to extract publications in the English language between January 2020 and December 2021 to report the incidence of OD alone or together with gustatory dysfunction (GD) among COVID-19 patients...
November 2023: Saudi Medical Journal
#9
JOURNAL ARTICLE
Kala Kumaresan, Sara Bengtsson, Saber Sami, Allan Clark, Thomas Hummel, James Boardman, Juliet High, Rashed Sobhan, Carl Philpott
BACKGROUND: Smell loss is a common problem with an estimated 5% of the population having no functioning sense of smell. Viral causes of smell loss are the second most common cause and the coronavirus (COVID-19) pandemic is estimated to have caused 20,000 more people this year to have a lasting loss of smell. Isolation, depression, anxiety, and risk of danger from hazards such as toxic gas and spoiled food are all negative impacts. It also affects appetite with weight loss/gain in two-thirds of those affected...
October 12, 2023: Pilot and Feasibility Studies
#10
Kelsey Barter, Francesca Bagnato
BACKGROUND: Vaccine-induced phantosmia is a rare adverse effect of vaccination and has not been previously reported related to the Johnson & Johnson (J&J) COVID-19 vaccine. CASE PRESENTATION: Three weeks after receiving the J&J COVID-19 vaccine, a 39-year-old veteran started smelling a burning odor in the absence of an identifiable source. At presentation to the clinic, his general and neurological examinations, brain magnetic resonance imaging, and electroencephalogram were all unremarkable...
September 2023: Federal Practitioner
#11
JOURNAL ARTICLE
Marcela Martončíková, Pavel Doležal, Kamila Fabianová, Miloslav Karhánek, Ján Gálik, Adam Raček, Alexandra Popovičová, Enikő Račeková
Olfactory dysfunction associated with coronavirus 2 (SARS-CoV-2) infection is in most cases transient, recovering spontaneously within a few days. However, in some patients it persists for a long time, affects their everyday life and endangers their health. Hence, we focused on patients with persistent loss of smell. The aim of this study was to evaluate olfactory dysfunction using a standardized test. Due to the pandemic, olfactory testing was performed online. Smell tests (Odorized Markers Test, OMT) were sent home to the patients...
August 28, 2023: Scientific Reports
#12
JOURNAL ARTICLE
Patrick Ioerger, Dorina Kallogjeri, Lauren Roland, John S Schneider, Jay F Piccirillo, Nyssa Fox Farrell
OBJECTIVE: Develop and validate a quality-of-life (QoL) outcome measure for patients with dysosmia. STUDY DESIGN: Cross-sectional survey study. SETTING: Otolaryngology clinics, research registries, and Facebook support groups. METHODS: A 59-item pilot survey with questions addressing parosmia concerns was developed using input from subjects with parosmia and clinical expertise from Otolaryngologists. After item reduction, the Parosmia Olfactory Dysfunction Outcomes Rating (DisODOR) was reduced to its final 29 items...
August 25, 2023: Otolaryngology—Head and Neck Surgery
#13
JOURNAL ARTICLE
Dibildox Daniel, Loyola-Nieto Paula, Brenner-Muslera Eduardo, Guerra-Arellano Daniel, Dib-Estephan Andrea, Loyola-Nieto Fernando, Maldonado-Cobá Armando
BACKGROUND: Quantitative (hyposmia and anosmia) and qualitative (phantosmia and parosmia) olfactory disorders are common consequences of COVID-19 infection found in more than 38% of patients even months after resolution of acute disease. SARS-CoV-2 has tropism for angiotensin-converting enzyme 2 (ACE2) in the respiratory system, suggesting that it is the mechanism of damage to the olfactory neuroepithelium and of involvement at the central nervous system. The olfactory bulb is the organ with the highest insulin uptake in the central nervous system...
January 2024: European Archives of Oto-rhino-laryngology
#14
Annelin Espetvedt, Siri Wiig, Kai Victor Myrnes-Hansen, Kolbjørn Kallesten Brønnick
BACKGROUND: There is a lack of overview of the tools used to assess qualitative olfactory dysfunction, including parosmia and phantosmia, following COVID-19 illness. This could have an impact on the diagnosis and treatment offered to patients. Additionally, the formulations of symptoms are inconsistent and often unclear, and consensus around the wording of questions and responses is needed. AIM OF STUDY: The aim of this systematic review is to provide an overview of tools used to assess qualitative olfactory dysfunction after COVID-19, in addition to addressing the content validity (i...
2023: Frontiers in Psychology
#15
JOURNAL ARTICLE
Cheol Hyo Ku, Ha Neul Lee, Sang Man Park, Hyun Su Lee, Jae Woo Lee, Se Hwa Hong, Dong-Joon Park, Eun Jung Lee
PURPOSE: Worldwide, the incidence of chronic fungal rhinosinusitis (CFRS) has increased. Although ageing leads to weakening of the immune system, which increases susceptibility to CFRS, the CFRS characteristics in geriatric patients are unclear. Therefore, we comparatively analysed the clinical characteristics of CFRS in geriatric and non-geriatric patients. METHODS: This retrospective analysis compared the demographics, rhinologic symptoms, multiple allergen simultaneous tests, olfactory function tests, paranasal sinus computed tomography findings, and outcomes of 131 patients with CFRS who underwent functional endoscopic sinus surgery and 131 enrolled patients were divided in geriatric (> 65 years) and non-geriatric (≤ 65 years) groups...
June 30, 2023: European Archives of Oto-rhino-laryngology
#16
JOURNAL ARTICLE
Yiling Mai, Celina Vogel, Julia Thiele, Tobias Hölscher, Thomas Hummel
PURPOSE: Patients sometimes report phosphene and phantosmia during radiation therapy (RT). However, the detail features and related factors are not well understood. Our prospective study aimed to investigate the characteristics of phantosmias and phosphenes, to identify factors that influence the occurrence, intensity and hedonic (pleasantness/unpleasantness) ratings of such sensations during RT. METHODS: We included a total of 106 patients (37 women), who underwent RT in regions of the brain, ear, nose, throat (ENT), and other areas of the body for a duration of 43 ± 5 days...
June 4, 2023: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
#17
JOURNAL ARTICLE
T-S Eo, H Y Lee, H-J Cho, J-H Yoon, M-S Rha, C-H Kim
BACKGROUND: Although interest in qualitative olfactory dysfunction (OD), including parosmia and phantosmia, has been increasing since the COVID-19 pandemic, little is known about the clinical characteristics and associated factors of qualitative OD. METHODS: Adult patients with subjective smell disturbance who underwent both the olfactory questionnaire and psychophysical olfactory function test were retrospectively enrolled. Demographic and clinical characteristics were analysed according to the presence or absence of parosmia or phantosmia...
May 27, 2023: Rhinology
#18
JOURNAL ARTICLE
Anja L Winter, Sofie Henecke, Johan N Lundström, Evelina Thunell
INTRODUCTION: Olfactory dysfunction is one of many long-lasting symptoms associated with COVID-19, estimated to affect approximately 60% of individuals and often lasting several months after infection. The associated daily life problems can cause a decreased quality of life. METHODS: Here, we assessed the association between perceived quality of life and both qualitative and quantitative olfactory function (distorted and weakened sense of smell, respectively) in 58 individuals who had undergone confirmed SARS-CoV-2 infection and who complained about olfactory dysfunction...
2023: Frontiers in Psychology
#19
David Dylan García-Meléndez, María Isabel Morales-Casado, Pilar Quintana Castro, Carlos Marsal Alonso
INTRODUCTION: Post-COVID olfactory dysfunction continues to be studied due to the controversy of the mechanisms involved. The aim was to investigate the olfactory dysfunctions in association with other post-COVID symptoms. MATERIAL AND METHODS: Observational, descriptive and single-center study. The patients had confirmed mild COVID-19 and subjective olfactory dysfunction of more than a month of evolution, which was assessed by Sniffin' Sticks Olfactory Test. RESULTS: A total of 86 patients participated...
April 21, 2023: Medicina clínica
#20
REVIEW
Anna Kristina Hernandez, Basile N. Landis, Aytug Altundag, Alexander Wieck Fjaeldstad, Simon Gane, Eric H Holbrook, Caroline Huart, Iordanis Konstantinidis, Matt Lechner, Alberto Macchi, Patricia Portillo Mazal, Takaki Miwa, Carl M Philpott, Jayant M Pinto, Sophia C Poletti, Jan Vodicka, Antje Welge-Luessen, Katherine L Whitcroft, Thomas Hummel
BACKGROUND: Definitions are essential for effective communication and discourse, particularly in science. They allow the shared understanding of a thought or idea, generalization of knowledge, and comparison across scientific investigation. The current terms describing olfactory dysfunction are vague and overlapping. SUMMARY: As a group of clinical olfactory researchers, we propose the standardization of the terms "dysosmia," "anosmia," "hyposmia," "normosmia," "hyperosmia," "olfactory intolerance," "parosmia," and "phantosmia" (or "olfactory hallucination") in olfaction-related communication, with specific definitions in this text...
April 14, 2023: ORL; Journal for Oto-rhino-laryngology and its related Specialties
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