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https://www.readbyqxmd.com/read/29222216/development-of-forced-normalisation-psychosis-with-ethosuximide
#1
Sean Apap Mangion, Fergus Rugg-Gunn
A 50-year-old man with known multidrug resistant coexistent focal and generalised epilepsy was commenced on ethosuximide, with normalisation of his electroencephalogram and cessation of absence seizures. Within 3 weeks, he developed a rapidly worsening paranoid psychosis with visual and olfactory hallucinations. A month after the cessation of ethosuximide and concurrent treatment with olanzapine, his psychosis resolved and permitted reinitiation of ethosuximide at a lower dose without recurrence of psychotic symptoms...
December 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29120562/be-vigilant-for-dementia-in-parkinson%C3%A2-s-disease
#2
Flavia Niccolini, Konstantinos Diamantopoulos, Stelios Kiosses, Marios Politis
It is estimated that up to 80% of patients with Parkinson's disease will eventually develop cognitive impairment over the course of their illness. Even at the time of diagnosis, cognitive impairment has been reported in 20-25% of patients. Commonly affected cognitive domains are executive function, visuospatial ability and attention control. In addition, patients with Parkinson's disease dementia may present with deficits in language function and verbal memory. Psychosis may occur in approximately 40% of patients with Parkinson's disease, and is associated with an increased risk of developing cognitive impairment...
May 2017: Practitioner
https://www.readbyqxmd.com/read/28972381/distinguishing-subjective-halitosis
#3
Murat Aydin, Mustafa Çağrı Derici, Defne Yalçın Yeler, Murat Özen Eren
Halitosis is chronic, endogenous malodor that is etiologically classified. Subjective halitosis, which may appear in clinically neurologic (neurogenic) or psychologic (psychogenic) forms, cannot be confirmed by using tests or performing visual inspection despite insistent complaints of malodor by the patient. Neurogenic forms mainly consist of chemosensory dysfunctions (dysguisa, dysosmia) and self-halitosis (retronasal olfaction, bloodborne olfactory receptor responses, phantosmia); whereas psychogenic forms are olfactory hallucinations, halitophobia, olfactory obsession, and delusional halitosis...
October 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28904824/a-case-of-unruptured-aneurysm-of-the-internal-carotid-artery-presenting-as-olfactory-hallucinations
#4
Jiro Akimoto, Norio Ichimasu, Rei Haraoka, Shinjiro Fukami, Michihiro Kohno
BACKGROUND: Olfactory hallucination, a symptom of medial temporal lobe epilepsy, is rarely associated with unruptured intracranial aneurysms. CASE DESCRIPTION: We encountered this situation in a 70-year-old woman with an unruptured aneurysm at the bifurcation of the internal carotid and posterior communicating artery. We were able to achieve epileptic control by craniotomy clipping and medial temporal lesionectomy. CONCLUSION: According to our knowledge, previous reports are limited to cases of large middle cerebral artery aneurysms compressing the lateral orbitofrontal cortex, and this is apparently the first report of a case where olfactory hallucinations occurred from direct stimulation of the entorhinal cortex by an internal carotid and posterior communicating artery bifurcation aneurysm...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28803382/cortical-afferent-inhibition-abnormalities-reveal-cholinergic-dysfunction-in-parkinson-s-disease-a-reappraisal
#5
REVIEW
Raffaele Nardone, Francesco Brigo, Viviana Versace, Yvonne Höller, Frediano Tezzon, Leopold Saltuari, Eugen Trinka, Luca Sebastianelli
Parkinson's disease (PD) is a multisystem neurodegenerative disorder affecting, besides the dopaminergic function, multiple neurotransmission systems, including the cholinergic system. Central cholinergic circuits of human brain can be tested non-invasively by coupling peripheral nerve stimulation with transcranial magnetic stimulation (TMS) of motor cortex; this test is named short latency afferent inhibition (SAI). SAI abnormalities have been reported in PD patients with gait disturbances and many non-motor symptoms, such as visual hallucinations (VHs), REM sleep behavior disorder (RBD), dysphagia, and olfactory impairment...
November 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28802919/nonmotor-signs-in-genetic-forms-of-parkinson-s-disease
#6
Meike Kasten, Connie Marras, Christine Klein
Although only a minority (i.e., ~5%) of Parkinson's disease (PD) cases is due to well-defined genetic causes, important clues about the common, "idiopathic" PD (iPD) can be garnered from monogenic model diseases. Nonmotor signs (NMS) are also present in monogenic PD and reviewed in this chapter for the confirmed PD genes SNCA, LRRK2, VPS35, Parkin, PINK1, DJ-1, and the risk factor gene GBA. Within the context of the MDSGene database (www.mdsgene.org), we performed a systematic literature search and extracted information on cognitive decline, depression, psychotic signs and symptoms, autonomic signs and symptoms, anxiety, sleep disorder, and olfactory impairment...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28625940/prodromal-stage-of-disease-dementia-with-lewy-bodies-how-to-diagnose-in-practice
#7
Frédéric Blanc, Marc Verny
Disease with Lewy bodies or dementia with Lewy bodies (DLB), particularly at the prodromal stage, is a complex disease to diagnose because of different clinical beginnings and variable paths in terms of clinical expression. Thus DLB can be entcountered in different input modes: mild cognitive impairment, depression, acute behavioral disorders, confusion and delirium, or sleep disorders. In the aim to better diagnose the disease, should be sought obviously to search for the key symptoms: fluctuations, hallucinations, extra-pyramidal syndrome, and REM sleep behavior disorder...
June 1, 2017: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
https://www.readbyqxmd.com/read/28484400/steroid-responsive-chronic-schizophreniform-syndrome-in-the-context-of-mildly-increased-antithyroid-peroxidase-antibodies
#8
Dominique Endres, Evgeniy Perlov, Anne Nicole Riering, Viktoria Maier, Oliver Stich, Rick Dersch, Nils Venhoff, Daniel Erny, Irina Mader, Ludger Tebartz van Elst
BACKGROUND: Schizophreniform syndromes can be divided into primary forms from polygenic causes or secondary forms due to immunological, epileptiform, monogenic, or degenerative causes. Steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is a secondary immunological form associated with increased thyroid antibodies, such as antithyroid peroxidase antibodies and shows a good response to corticosteroids. CASE PRESENTATION: We present the case of a 41-year-old woman suffering from a schizophreniform syndrome...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28455892/psychotic-symptoms-as-a-complication-of-electroconvulsive-therapy-a-case-report
#9
Anna Antosik-Wójcińska, Magdalena Chojnacka, Łukasz Święcicki
We report a patient who experienced atypical symptoms in the course of electroconvulsive therapy (ECT). During ECT treatment patient experienced psychotic symptoms which should be differentiated with prolonged delirium and nonconvulsive status epilepticus. 46-year-old female was referred to hospital with a diagnosis of major depressive disorder with no psychotic features in the course of recurrent depression. Despite several changes of pharmacological treatment no improvement was achieved, therefore it was decided to initiate ECT...
February 26, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/28282630/differences-in-the-symptom-profile-of-methamphetamine-related-psychosis-and-primary-psychotic-disorders
#10
Rebecca McKetin, Amanda L Baker, Sharon Dawe, Alexandra Voce, Dan I Lubman
We examined the lifetime experience of hallucinations and delusions associated with transient methamphetamine-related psychosis (MAP), persistent MAP and primary psychosis among a cohort of dependent methamphetamine users. Participants were classified as having (a) no current psychotic symptoms, (n=110); (b) psychotic symptoms only when using methamphetamine (transient MAP, n=85); (c) psychotic symptoms both when using methamphetamine and when abstaining from methamphetamine (persistent MAP, n=37), or (d) meeting DSM-IV criteria for lifetime schizophrenia or mania (primary psychosis, n=52)...
May 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28273630/occurrence-and-co-occurrence-of-hallucinations-by-modality-in-schizophrenia-spectrum-disorders
#11
Simon McCarthy-Jones, David Smailes, Aiden Corvin, Michael Gill, Derek W Morris, Timothy G Dinan, Kieran C Murphy, F Anthony O Neill, John L Waddington, Australian Schizophrenia Research Bank, Gary Donohoe, Robert Dudley
It is not only unclear why hallucinations in schizophrenia occur with different prevalence by modality, but also to what extent they do. Reliable prevalence estimates of hallucinations by modality in schizophrenia are currently lacking, particularly for non-auditory hallucinations. Studies have also tended to report lifetime, not point prevalence by modality. This study assessed the prevalence and co-occurrence of hallucinations, for both lifetime and point prevalence, across the auditory, visual, olfactory, and tactile modalities, in people diagnosed with chronic schizophrenia-spectrum disorders in Ireland (N=693) and Australia (N=218)...
June 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28038387/on-the-nose-olfactory-disturbances-in-patients-with-transient-epileptic-amnesia
#12
Sharon A Savage, Christopher R Butler, Fraser Milton, Yang Han, Adam Z Zeman
OBJECTIVE: While olfactory hallucinations are relatively rare in epilepsy, a high prevalence (up to 42%) has been reported in one form - Transient Epileptic Amnesia (TEA). TEA is characterized by recurring amnestic seizures and is commonly associated with persistent interictal memory deficits. Despite reports of changes in smell, olfactory ability has not been objectively assessed in this group. The aim of this study was to measure olfactory ability in patients with TEA and explore whether olfactory symptoms relate to other clinical variables...
January 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28012950/a-dose-effect-of-mutations-in-the-gba-gene-on-parkinson-s-disease-phenotype
#13
Avner Thaler, Tanya Gurevich, Anat Bar Shira, Mali Gana Weisz, Elissa Ash, Tamara Shiner, Avi Orr-Urtreger, Nir Giladi, Anat Mirelman
OBJECTIVE: Mutations in the GBA gene are associated with Parkinson's disease (PD). A definite description of the clinical characteristics of PD patients who are compound heterozygotes or homozygotes for mutations in the GBA gene (GD-PD) requires further elucidation. METHODS: We assessed motor, cognitive, olfactory and autonomic functions as well as demographic data and medical history in a cohort of Ashkenazi Jewish PD patients who were screened for seven common mutations in the GBA gene...
March 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27980286/a-case-of-successful-treatment-with-donepezil-of-olfactory-hallucination-in-parkinson-disease
#14
Osamu Osada, Akira Iwasaki
We report a 74-year-old female patient with Parkinson disease (PD). Around 2010, she developed depression and bradykinesia and was diagnosed as PD. In July 2014, she came to our hospital, of which she lived in the neighborhood. In the last part of December 2014, she felt uneasy about her fecal smell and saw a psychiatrist in the first part of January 2015. Quetiapine (25 mg/day) was added. In the last part of January, she complained of fecal smell everywhere and could not take a meal. No-one else could detect the smell...
January 31, 2017: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27905557/hallucinations-in-schizophrenia-and-parkinson-s-disease-an-analysis-of-sensory-modalities-involved-and-the-repercussion-on-patients
#15
P M Llorca, B Pereira, R Jardri, I Chereau-Boudet, G Brousse, D Misdrahi, G Fénelon, A-M Tronche, R Schwan, C Lançon, A Marques, M Ulla, P Derost, B Debilly, F Durif, I de Chazeron
Hallucinations have been described in various clinical populations, but they are neither disorder nor disease specific. In schizophrenia patients, hallucinations are hallmark symptoms and auditory ones are described as the more frequent. In Parkinson's disease, the descriptions of hallucination modalities are sparse, but the hallucinations do tend to have less negative consequences. Our study aims to explore the phenomenology of hallucinations in both hallucinating schizophrenia patients and Parkinson's disease patients using the Psycho-Sensory hAllucinations Scale (PSAS)...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27779326/olfactory-symptoms-reported-by-migraineurs-with-and-without-auras
#16
Marco Aurélio Fornazieri, Anibal Rodrigues Neto, Fabio de Rezende Pinna, Fabio Henrique Gobbi Porto, Paulo de Lima Navarro, Richard Louis Voegels, Richard L Doty
OBJECTIVE: Olfaction-related symptoms accompany migraine attacks and some, such as osmophobia, may be useful in differentiating migraine from other types of headaches. However, the types and frequencies of olfactory symptoms associated with migraine have not been well characterized. The goal of this study was to better characterize the olfactory symptoms of migraine. METHODS: A cross-sectional study was devised. One hundred and thirteen patients who met the International Classification of Headache Disorders II criteria for migraine were administered a new 65-item questionnaire specifically focused on olfaction-related experiences (eg, odor-related triggers, osmophobia, cacosmia, phantosmia, olfactory hallucinations, olfactory hypersensitivity, and self-perceived olfactory function)...
November 2016: Headache
https://www.readbyqxmd.com/read/27765426/diffusion-alterations-associated-with-parkinson-s-disease-symptomatology-a-review-of-the-literature
#17
REVIEW
Julie M Hall, Kaylena A Ehgoetz Martens, Courtney C Walton, Claire O'Callaghan, Peter E Keller, Simon J G Lewis, Ahmed A Moustafa
Parkinson's disease (PD) is a heterogeneous neurological disorder with a variety of motor and non-motor symptoms. The underlying mechanisms of these symptoms are not fully understood. An increased interest in structural connectivity analyses using diffusion tensor imaging (DTI) in PD has led to an expansion of our understanding of the impact of abnormalities in diffusivity on phenotype. This review outlines the contribution of these abnormalities to symptoms of PD including bradykinesia, tremor and non-tremor phenotypes, freezing of gait, cognitive impairment, mood, sleep disturbances, visual hallucinations and olfactory dysfunction...
December 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27752826/psychopathological-and-demographic-characteristics-of-hallucinating-patients-with-schizophrenia-and-schizoaffective-disorder-an-analysis-based-on-amdp-data
#18
Christopher Baethge, Michaela Jänner, Wolfgang Gaebel, Jaroslav Malevani
Hallucinations are at the core of the diagnosis of schizophrenia and schizoaffective disorders, and many neuroscience studies focus on hallucinations. However, there is a lack of data on prevalence, subtyping, and clinical correlates of hallucinations as well as on the comparison of hallucinating schizophrenia versus hallucinating schizoaffective patients. Analysis of all psychopathology evaluations is based on the AMDP scale in a German psychiatric university hospital between 2007 and 2013 regarding patients with schizophrenia or schizoaffective disorder (diagnosed according to ICD-10)...
June 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/27515987/trigeminal-nerve-stimulation-for-olfactory-hallucinations-in-schizophrenia-case-study
#19
July Silveira Gomes, Henrique Akiba, Álvaro M Dias, Amanda Soares, Ivan Taiar, Ary A Gadelha, Quirino Cordeiro, Pedro Shiozawa
No abstract text is available yet for this article.
October 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27454215/catatonia-and-psychosis-related-to-epilepsy-a-case-report
#20
Laiana Quagliato, Roberto Piedade, Cristina Santana, Elie Cheniaux
Although a variety of metabolic, toxic, psychiatric, and neurologic conditions can produce catatonic syndromes, it is less widely recognized that this state may be caused by epilepsy. We present the case of a woman with catatonic behavior, which she could not recall. She also exhibited olfactory, auditory and visual hallucinations. An EEG demonstrated diffuse abnormal electrical activity, mainly on left temporal and frontal areas. Treatment with anticonvulsant drugs yielded excellent response.
July 25, 2016: Clinical Schizophrenia & related Psychoses
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