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Alessio Fasano

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https://www.readbyqxmd.com/read/28624097/serum-zonulin-gut-permeability-and-the-pathogenesis-of-autism-spectrum-disorders-cause-effect-or-an-epiphenomenon
#1
EDITORIAL
Alessio Fasano, Ivor Hill
No abstract text is available yet for this article.
June 14, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28452345/hmga1-amplifies-wnt-signalling-and-expands-the-intestinal-stem-cell-compartment-and-paneth-cell-niche
#2
Lingling Xian, Dan Georgess, Tait Huso, Leslie Cope, Amy Belton, Yu-Ting Chang, Wenyong Kuang, Qihua Gu, Xiaoyan Zhang, Stefania Senger, Alessio Fasano, David L Huso, Andrew J Ewald, Linda M S Resar
High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. Prior studies showed that Hmga1 drives hyperproliferation, aberrant crypt formation and polyposis in transgenic mice. Here we demonstrate that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and expand the ISC compartment. Hmga1 upregulates genes encoding both Wnt agonist receptors and downstream Wnt effectors. Hmga1 also helps to 'build' an ISC niche by expanding the Paneth cell compartment and directly inducing Sox9, which is required for Paneth cell differentiation...
April 28, 2017: Nature Communications
https://www.readbyqxmd.com/read/28423466/zonulin-transgenic-mice-show-altered-gut-permeability-and-increased-morbidity-mortality-in-the-dss-colitis-model
#3
Craig Sturgeon, Jinggang Lan, Alessio Fasano
Increased small intestinal permeability (IP) has been proposed to be an integral element, along with genetic makeup and environmental triggers, in the pathogenies of chronic inflammatory diseases (CIDs). We identified zonulin as a master regular of intercellular tight junctions linked to the development of several CIDs. We aim to study the role of zonulin-mediated IP in the pathogenesis of CIDs. Zonulin transgenic Hp2 mice (Ztm) were subjected to dextran sodium sulfate (DSS) treatment for 7 days, followed by 4-7 days' recovery and compared to C57Bl/6 (wild-type (WT)) mice...
June 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28356988/complete-response-to-capecitabine-in-a-frail-elderly-patient-with-metastatic-colorectal-cancer-a-case-report
#4
Morena Fasano, Alessio Fabozzi, Guido Giordano, Filippo Venturini, Gaetano Aurilio, Flavia Cantile, Teresa Fabozzi, Vincenzo Ricci, Giuseppe Santabarbara, Floriana Morgillo, Fortunato Ciardiello, Ferdinando De Vita
The clinical management of frail, elderly patients affected by colorectal cancer (CRC) remains a subject of debate. The present study reports the case of an elderly man with metastatic CRC (mCRC) who was successfully treated with capecitabine. The patient survived for 29 months, thus highlighting its potential activity in terms of obtaining a complete response and high efficacy. A 77-year-old man presented with adenocarcinoma of the rectum with multiple and synchronous liver metastases, in addition to several comorbidities...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28219968/celiac-disease-gut-brain-axis-and-behavior-cause-consequence-or-merely-epiphenomenon
#5
Alessio Fasano
No abstract text is available yet for this article.
March 2017: Pediatrics
https://www.readbyqxmd.com/read/28159311/intestinal-barrier-maturation-in-very-low-birthweight-infants-relationship-to-feeding-and-antibiotic-exposure
#6
COMPARATIVE STUDY
Bushra Saleem, Adora C Okogbule-Wonodi, Alessio Fasano, Laurence S Magder, Jacques Ravel, Shiv Kapoor, Rose M Viscardi
OBJECTIVE: To test the hypothesis that feeding and antibiotic exposures affect intestinal barrier maturation in preterm infants, we serially measured intestinal permeability (IP) biomarkers in infants <33 weeks gestation (gestational age [GA]) during the first 2 weeks of life. STUDY DESIGN: Eligible infants <33 weeks GA were enrolled within 4 days of birth in a prospective study of IP biomarkers (NCT01756040). Study participants received the nonmetabolized sugars lactulose/rhamnose enterally on study days 1, 8, and 15 and lactulose/rhamnose were measured in urine by high-performance liquid chromatography...
April 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28122648/microbiota-transfer-therapy-alters-gut-ecosystem-and-improves-gastrointestinal-and-autism-symptoms-an-open-label-study
#7
Dae-Wook Kang, James B Adams, Ann C Gregory, Thomas Borody, Lauren Chittick, Alessio Fasano, Alexander Khoruts, Elizabeth Geis, Juan Maldonado, Sharon McDonough-Means, Elena L Pollard, Simon Roux, Michael J Sadowsky, Karen Schwarzberg Lipson, Matthew B Sullivan, J Gregory Caporaso, Rosa Krajmalnik-Brown
BACKGROUND: Autism spectrum disorders (ASD) are complex neurobiological disorders that impair social interactions and communication and lead to restricted, repetitive, and stereotyped patterns of behavior, interests, and activities. The causes of these disorders remain poorly understood, but gut microbiota, the 10(13) bacteria in the human intestines, have been implicated because children with ASD often suffer gastrointestinal (GI) problems that correlate with ASD severity. Several previous studies have reported abnormal gut bacteria in children with ASD...
January 23, 2017: Microbiome
https://www.readbyqxmd.com/read/28112686/value-of-iga-ttg-in-predicting-mucosal-recovery-in-children-with-celiac-disease-on-a-gluten-free-diet
#8
Maureen M Leonard, Dascha C Weir, Maya DeGroote, Paul D Mitchell, Prashant Singh, Jocelyn A Silvester, Alan M Leichtner, Alessio Fasano
OBJECTIVES: Our objective was to determine the rate of mucosal recovery in pediatric patients with celiac disease on a gluten-free diet. We also sought to determine whether immunoglobulin A tissue transglutaminase (tTG) correlates with mucosal damage at the time of a repeat endoscopy with duodenal biopsy in these patients. METHODS: We performed a retrospective chart review of 103 pediatric patients, younger than 21 years, with a diagnosis of celiac disease defined as Marsh 3 histology, and who underwent a repeat endoscopy with duodenal biopsy at least 12 months after initiating a gluten-free diet...
February 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28069576/dysbiosis-and-zonulin-upregulation-alter-gut-epithelial-and-vascular-barriers-in-patients-with-ankylosing-spondylitis
#9
Francesco Ciccia, Giuliana Guggino, Aroldo Rizzo, Riccardo Alessandro, Michele Maria Luchetti, Simon Milling, Laura Saieva, Heleen Cypers, Tommaso Stampone, Paola Di Benedetto, Armando Gabrielli, Alessio Fasano, Dirk Elewaut, Giovanni Triolo
BACKGROUND: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied. The aim of this study was to investigate the role of ileal bacteria in modulating local and systemic immune responses in AS. METHODS: Ileal biopsies were obtained from 50 HLA-B27(+) patients with AS and 20 normal subjects. Silver stain was used to visualise bacteria. Ileal expression of tight and adherens junction proteins was investigated by TaqMan real-time (RT)-PCR and immunohistochemistry...
June 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28034662/the-perspective-of-celiac-disease-patients-on-emerging-treatment-options-and-non-celiac-gluten-sensitivity
#10
Thomas Greuter, Sandra Schmidlin, Jaqueline Lattmann, Matthias Stotz, Romina Lehmann, Jonas Zeitz, Michael Scharl, Benjamin Misselwitz, Daniel Pohl, Michael Fried, Radu Tutuian, Alessio Fasano, Alain M Schoepfer, Gerhard Rogler, Luc Biedermann, Stephan R Vavricka
BACKGROUND: Non-celiac gluten sensitivity (NCGS) and emerging treatment options are hot topics in the celiac disease (CeD) scientific literature. However, very little is known about the perspective on these issues of CeD patients. METHODS: We performed a large patient survey among unselected CeD patients in Switzerland. RESULTS: A total of 1689 patients were analyzed. 57.5% have previously heard of NCGS. 64.5% believe in the existence of this entity...
March 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28003208/gut-permeability-obesity-and-metabolic-disorders-who-is-the-chicken-and-who-is-the-egg
#11
Alessio Fasano
No abstract text is available yet for this article.
January 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27957319/blood-brain-barrier-and-intestinal-epithelial-barrier-alterations-in-autism-spectrum-disorders
#12
Maria Fiorentino, Anna Sapone, Stefania Senger, Stephanie S Camhi, Sarah M Kadzielski, Timothy M Buie, Deanna L Kelly, Nicola Cascella, Alessio Fasano
BACKGROUND: Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood-brain barrier (BBB), can be part of the chain of events leading to these disorders...
2016: Molecular Autism
https://www.readbyqxmd.com/read/27936497/proinflammatory-cytokine-interferon-%C3%AE-and-microbiome-derived-metabolites-dictate-epigenetic-switch-between-forkhead-box-protein-3-isoforms-in-coeliac-disease
#13
G Serena, S Yan, S Camhi, S Patel, R S Lima, A Sapone, M M Leonard, R Mukherjee, B J Nath, K M Lammers, A Fasano
Coeliac disease (CD) is an autoimmune enteropathy triggered by gluten and characterized by a strong T helper type 1 (Th1)/Th17 immune response in the small intestine. Regulatory T cells (Treg ) are CD4(+) CD25(++) forkhead box protein 3 (FoxP3(+) ) cells that regulate the immune response. Conversely to its counterpart, FoxP3 full length (FL), the alternatively spliced isoform FoxP3 Δ2, cannot properly down-regulate the Th17-driven immune response. As the active state of CD has been associated with impairments in Treg cell function, we aimed at determining whether imbalances between FoxP3 isoforms may be associated with the disease...
March 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27918479/tempters-and-gluten-free-diet
#14
EDITORIAL
Carlo Catassi, Alessio Fasano
n/a.
December 3, 2016: Nutrients
https://www.readbyqxmd.com/read/27694935/interplay-between-hydrophilicity-and-surface-barriers-on-water-transport-in-zeolite-membranes
#15
Matteo Fasano, Thomas Humplik, Alessio Bevilacqua, Michael Tsapatsis, Eliodoro Chiavazzo, Evelyn N Wang, Pietro Asinari
A comprehensive understanding of molecular transport within nanoporous materials remains elusive in a broad variety of engineering and biomedical applications. Here, experiments and atomistic simulations are synergically used to elucidate the non-trivial interplay between nanopore hydrophilicity and surface barriers on the overall water transport through zeolite crystals. At these nanometre-length scales, these results highlight the dominating effect of surface imperfections with reduced permeability on the overall water transport...
October 3, 2016: Nature Communications
https://www.readbyqxmd.com/read/27690129/biomarkers-of-environmental-enteropathy-inflammation-stunting-and-impaired-growth-in-children-in-northeast-brazil
#16
Richard L Guerrant, Alvaro M Leite, Relana Pinkerton, Pedro H Q S Medeiros, Paloma A Cavalcante, Mark DeBoer, Margaret Kosek, Christopher Duggan, Andrew Gewirtz, Jonathan C Kagan, Anna E Gauthier, Jonathan Swann, Jordi Mayneris-Perxachs, David T Bolick, Elizabeth A Maier, Marjorie M Guedes, Sean R Moore, William A Petri, Alexandre Havt, Ila F Lima, Mara de Moura Gondim Prata, Josyf C Michaleckyj, Rebecca J Scharf, Craig Sturgeon, Alessio Fasano, Aldo A M Lima
Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and predict its effects on growth and development. We therefore assessed fecal, urinary and systemic biomarkers of enteropathy and growth predictors in 375 6-26 month-old children with varying degrees of malnutrition (stunting or wasting) in Northeast Brazil. 301 of these children returned for followup anthropometry after 2-6m...
2016: PloS One
https://www.readbyqxmd.com/read/27636410/celiac-disease-is-misdiagnosed-based-on-serology-only-in-a-substantial-proportion-of-patients
#17
Stephan R Vavricka, Teresa Stelzer, Jaqueline Lattmann, Matthias Stotz, Romina Lehmann, Jonas Zeitz, Michael Scharl, Benjamin Misselwitz, Daniel Pohl, Michael Fried, Radu Tutuian, Alessio Fasano, Alain M Schoepfer, Gerhard Rogler, Luc Biedermann, Thomas Greuter
BACKGROUND: Although the diagnostic process in celiac disease (CeD) has been addressed in several international guidelines, little is known about the actual proceeding in current clinical practice. This study investigated the initial presentation, the diagnostic process, follow-up evaluations, and adherence to a gluten-free diet in CeD patients in a real-life setting in Switzerland from a patient's perspective. METHODS: We performed a large patient survey among unselected CeD patients in Switzerland...
September 15, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27634626/transitioning-from-descriptive-to-mechanistic-understanding-of-the-microbiome-the-need-for-a-prospective-longitudinal-approach-to-predicting-disease
#18
Victoria J Martin, Maureen M Leonard, Lauren Fiechtner, Alessio Fasano
No abstract text is available yet for this article.
December 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27565547/evidence-informed-expert-recommendations-for-the-management-of-celiac-disease-in-children
#19
John Snyder, J Decker Butzner, Amy R DeFelice, Alessio Fasano, Stefano Guandalini, Edwin Liu, Kimberly P Newton
Although the need for effective long-term follow-up for patients with celiac disease (CD) has been recognized by many expert groups, published practice guidelines have not provided a clear approach for the optimal management of these patients. In an attempt to provide a thoughtful and practical approach for managing these patients, a group of experts in pediatric CD performed a critical review of the available literature in 6 categories associated with CD to develop a set of best practices by using evidence-based data and expert opinion...
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27500889/development-of-a-multicellular-three-dimensional-organotypic-model-of-the-human-intestinal-mucosa-grown-under-microgravity
#20
Rosangela Salerno-Goncalves, Alessio Fasano, Marcelo B Sztein
Because cells growing in a three-dimensional (3-D) environment have the potential to bridge many gaps of cell cultivation in 2-D environments (e.g., flasks or dishes). In fact, it is widely recognized that cells grown in flasks or dishes tend to de-differentiate and lose specialized features of the tissues from which they were derived. Currently, there are mainly two types of 3-D culture systems where the cells are seeded into scaffolds mimicking the native extracellular matrix (ECM): (a) static models and (b) models using bioreactors...
2016: Journal of Visualized Experiments: JoVE
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