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https://www.readbyqxmd.com/read/28747452/mri-guided-focused-ultrasound-thalamotomy-in-non-et-tremor-syndromes
#1
Alfonso Fasano, Maheleth Llinas, Renato P Munhoz, Eugen Hlasny, Walter Kucharczyk, Andres M Lozano
OBJECTIVE: To report the 6-month single-blinded results of unilateral thalamotomy with MRI-guided focused ultrasound (MRgFUS) in patients with tremors other than essential tremor. METHODS: Three patients with tremor due to Parkinson disease, 2 with dystonic tremor in the context of cervicobrachial dystonia and writer's cramp, and 1 with dystonia gene-associated tremor underwent MRgFUS targeting the ventro-intermedius nucleus (Vim) of the dominant hemisphere. The primary endpoint was the reduction of lateralized items of the Tremor Rating Scale of contralateral hemibody assessed by a blinded rater...
July 26, 2017: Neurology
https://www.readbyqxmd.com/read/28739219/systematic-review-of-hardware-related-complications-of-deep-brain-stimulation-do-new-indications-pose-an-increased-risk
#2
Onanong Jitkritsadakul, Roongroj Bhidayasiri, Suneil K Kalia, Mojgan Hodaie, Andres M Lozano, Alfonso Fasano
INTRODUCTION: Deep Brain Stimulation (DBS) is an effective treatment extended broadly to many neurological and psychiatric disorders. Nevertheless, complications may arise during DBS procedures or following implantation due to implanted hardware. This may result in both minor and major adverse events that may necessitate hardware removal and/or compromise maximal therapeutic benefit for the patient. OBJECTIVES AND METHODS: To identify relevant literature on hardware-related complications from DBS procedures by performing a systematic review, and propose how to identify at-risk group and possible preventive approaches...
July 13, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28729090/the-overlap-between-essential-tremor-and-parkinson-disease
#3
Musleh Algarni, Alfonso Fasano
INTRODUCTION: Essential tremor (ET) and Parkinson's disease (PD) are common disorders especially in the aging population and can have overlapping features that can make it difficult to differentiate between the two. In addition, a possible overlap from a pathophysiological standpoint has been often advocated in the past. METHODS: In this review article, we gather the recent evidence in favor or against a possible relationship between ET and PD. This exercise follows the new advances in the field of tremor from both a pathophysiological and nosological perspective...
July 12, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28717173/liquid-phase-sequence-capture-and-targeted-re-sequencing-revealed-novel-polymorphisms-in-tomato-genes-belonging-to-the-mep-carotenoid-pathway
#4
Irma Terracciano, Concita Cantarella, Carlo Fasano, Teodoro Cardi, Giuseppe Mennella, Nunzio D'Agostino
Tomato (Solanum lycopersicum L.) plants are characterized by having a variety of fruit colours that reflect the composition and accumulation of diverse carotenoids in the berries. Carotenoids are extensively studied for their health-promoting effects and this explains the great attention these pigments received by breeders and researchers worldwide. In this work we applied Agilent's SureSelect liquid-phase sequence capture and Illumina targeted re-sequencing of 34 tomato genes belonging to the methylerythritol phosphate (MEP) carotenoid pathway on a panel of 48 genotypes which differ for carotenoid content calculated as the sum of β-carotene, cis- and trans-lycopene...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28712731/cervical-dystonia-patients-display-subclinical-gait-changes
#5
Marcello Esposito, Raffaele Dubbioso, Silvio Peluso, Antonio Picone, Bruno Corrado, Clemente Servodio Iammarone, Roberto Allocca, Fiore Manganelli, Lucio Santoro, Alfonso Fasano
INTRODUCTION: Gait disorders in cervical dystonia (CD) are reported in patients under DBS or in severe cases complicated with spinal deformities. OBJECTIVE: to assess walking motor pattern in CD patients without DBS and not presenting scoliosis. METHODS: Computerized gait analysis (CGA) was performed in CD patients, before and after botulinum toxin (BoNT) injections, and in healthy controls (HC). Spatiotemporal (ST) parameters were compared between CD and HC groups...
July 10, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28681922/spinal-cord-stimulation-in-primary-progressive-freezing-of-gait
#6
REVIEW
Mohammad Rohani, Sukhvinder Kalsi-Ryan, Andres M Lozano, Alfonso Fasano
No abstract text is available yet for this article.
July 6, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28668055/nonequilibrium-molecular-dynamics-simulations-of-nanoconfined-fluids-at-solid-liquid-interfaces
#7
M Morciano, M Fasano, A Nold, C Braga, P Yatsyshin, D N Sibley, B D Goddard, E Chiavazzo, P Asinari, S Kalliadasis
We investigate the hydrodynamic properties of a Lennard-Jones fluid confined to a nanochannel using molecular dynamics simulations. For channels of different widths and hydrophilic-hydrophobic surface wetting properties, profiles of the fluid density, stress, and viscosity across the channel are obtained and analysed. In particular, we propose a linear relationship between the density and viscosity in confined and strongly inhomogeneous nanofluidic flows. The range of validity of this relationship is explored in the context of coarse grained models such as dynamic density functional-theory...
June 28, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28665252/deep-brain-stimulation-for-parkinson-s-disease-meta-analysis-of-results-of-randomized-trials-at-varying-lengths-of-follow-up
#8
Alireza Mansouri, Shervin Taslimi, Jetan H Badhiwala, Christopher D Witiw, Farshad Nassiri, Vincent J J Odekerken, Rob M A De Bie, Suneil K Kalia, Mojgan Hodaie, Renato P Munhoz, Alfonso Fasano, Andres M Lozano
OBJECTIVE Deep brain stimulation (DBS) is effective in the management of patients with advanced Parkinson's disease (PD). While both the globus pallidus pars interna (GPi) and the subthalamic nucleus (STN) are accepted targets, their relative efficacy in randomized controlled trials (RCTs) has not been established beyond 12 months. The objective of this study was to conduct a meta-analysis of RCTs to compare outcomes among adults with PD undergoing DBS of GPi or STN at various time points, including 36 months of follow-up...
June 30, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28659047/health-status-and-concomitant-prescription-of-immunosuppressants-are-risk-factors-for-hydroxychloroquine-non-adherence-in-systemic-lupus-patients-with-prolonged-inactive-disease
#9
M Iudici, I Pantano, S Fasano, L Pierro, B Charlier, M Pingeon, F Dal Piaz, A Filippelli, V Izzo
Background/objective The objectives of this paper are to assess the extent of and the factors associated with hydroxychloroquine (HCQ) non-adherence in systemic lupus erythematosus (SLE) patients with prolonged inactive disease and to investigate relationships between blood HCQ concentration and quality of life (QoL). Methods Consecutive SLE patients, in remission for at least one year and taking a stable dose of HCQ were investigated. At study entry (T0) and six months later (T6) a blood venous sample was taken to measure whole blood concentration of [HCQ] and desethylchloroquine ([DCQ])...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28642996/central-conduction-abnormalities-in-patients-receiving-levodopa-carbidopa-intestinal-gel-infusion
#10
Francesco Bove, Marco Luigetti, Lara Gallicchio, Valentina Recchia, Antonella Petruzzellis, Riccardo Di Iorio, Filippo Tamma, Alfonso Fasano
In recent years, several studies have reported a relatively high frequency of polyneuropathy in patients with Parkinson's disease (PD), in particular, in patients receiving levodopa-carbidopa intestinal gel (LCIG) infusion. In spite of the several patients investigated with nerve conduction studies, no study has prospectively explored a possible central nervous system involvement of patients receiving LCIG infusion. We prospectively evaluated eight PD patients receiving LCIG infusion, who underwent neurophysiological evaluations with nerve conduction studies, visual, somatosensory and motor evoked potentials before LCIG infusion, and 1 and 6 months after...
June 22, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28642123/multiple-sclerosis-tremor-are-technical-advances-enough
#11
Derrick Soh, Alfonso Fasano
No abstract text is available yet for this article.
June 19, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28631862/thalamic-deep-brain-stimulation-for-orthostatic-tremor-a-multicenter-international-registry
#12
Aristide Merola, Alfonso Fasano, Anhar Hassan, Jill L Ostrem, Maria Fiorella Contarino, Mark Lyons, Joachim K Krauss, Marc E Wolf, Bryan T Klassen, Anne-Fleur van Rootselaar, Ignacio Regidor, Andrew P Duker, William Ondo, Jorge Guridi, Jens Volkmann, Aparna Wagle Shukla, George T Mandybur, Michael S Okun, Karsten Witt, Philip A Starr, Günther Deuschl, Alberto J Espay
BACKGROUND: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. METHODS: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (≥48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications...
June 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28629409/correlation-between-knowledge-on-transmission-and-prevention-of-hiv-sti-and-proficiency-in-condom-use-among-male-migrants-from-africa-and-middle-east-evaluated-by-a-condom-use-skills-score-using-a-wooden-penile-model
#13
Fabio Zoboli, Domenico Martinelli, Mariantonietta Di Stefano, Massimo Fasano, Rosa Prato, Teresa Antonia Santantonio, Jose' Ramòn Fiore
BACKGROUND: Migrants in Italy are prevalently young adults, with a higher risk of sexual transmitted infections (STI) and HIV infection. Promoting consistent as well as correct use of condoms could reduce failure rate due to their improper use. The aim of our study was to evaluate Condom Use Skills among a migrant population recently landed in Italy, hosted in a government center for asylum seekers. METHODS: The study sample was composed of 80 male migrants. Sanitary trained interviewers submitted a questionnaire to participants to investigate age, provenience, marital status, educational level and knowledge about transmission and prevention of HIV/STI...
June 19, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28624097/serum-zonulin-gut-permeability-and-the-pathogenesis-of-autism-spectrum-disorders-cause-effect-or-an-epiphenomenon
#14
EDITORIAL
Alessio Fasano, Ivor Hill
No abstract text is available yet for this article.
June 14, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28620861/testing-a-ratio-of-photosynthesis-to-o3-uptake-as-an-index-for-assessing-o3-induced-foliar-visible-injury-in-poplar-trees
#15
Yasutomo Hoshika, Elisa Carrari, Lu Zhang, Giulia Carriero, Sara Pignatelli, Gianni Fasano, Alessandro Materassi, Elena Paoletti
Visible foliar injury by ozone (ozone visible injury) is known as a biomarker to assess potential phytotoxicity of ozone. We investigated ozone visible injury in an ozone-sensitive poplar (Oxford clone) under a 2-year free-air controlled exposure (FACE) experiment and calculated three ozone indices (i.e., accumulative ozone exposure over 40 ppb during daylight hours (AOT40), phytotoxic ozone dose above a flux threshold of 0 nmol m(-2) s(-1) (POD0), and the cumulative value of the ratio of hourly ozone uptake to net photosynthesis (ΣU/P n ) to assess the critical level (CL) at the time of the first symptom onset of ozone visible injury...
June 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28608991/frustrated-lewis-pair-mediated-1-2-hydrocarbation-of-alkynes
#16
Valerio Fasano, Liam D Curless, James E Radcliffe, Michael J Ingleson
Frustrated Lewis pair (FLP) chemistry enables a rare example of alkyne 1,2-hydrocarbation with N-methylacridinium salts as the carbon Lewis acid. This 1,2-hydrocarbation process does not proceed through a concerted mechanism as in alkyne syn-hydroboration, or through an intramolecular 1,3-hydride migration as operates in the only other reported alkyne 1,2-hydrocarbation reaction. Instead, in this study, alkyne 1,2-hydrocarbation proceeds by a novel mechanism involving alkyne dehydrocarbation with a carbon Lewis acid based FLP to form the new C-C bond...
June 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28608578/cantharidin-inhibits-competitively-heme-fe-iii-binding-to-the-fa1-site-of-human-serum-albumin
#17
Fabio Polticelli, Loris Leboffe, Valentina Tortosa, Viviana Trezza, Gabriella Fanali, Mauro Fasano, Paolo Ascenzi
Cantharidin, a monoterpene isolated from the insect blister beetle, has long been used as a medicinal agent in the traditional Chinese medicine. Cantharidin inhibits a subgroup of serine/threonine phosphatases, thus inducing cell growth inhibition and cytotoxicity. Cantharidin has anticancer activity in vitro, since it is able of inducing p53-dependent apoptosis and double-strand breakage of DNA in cancer cells. Although the toxicity of cantharidin to the gastrointestinal and urinary tracts prevents its medical use, it is a promising lead compound for chemical modification to develop new anticancer therapeutics...
June 13, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28597132/lung-involvement-in-stable-undifferentiated-connective-tissue-diseases-a-rheumatology-perspective
#18
Antonella Riccardi, Rosaria Irace, Ilaria Di Stefano, Michele Iudici, Serena Fasano, Marialuisa Bocchino, Annalisa Capaccio, Alessandro Sanduzzi, Gabriele Valentini
Previous studies of the occurrence of interstitial lung disease (ILD) in undifferentiated connective tissue diseases (UCTD) were conducted in patients admitted to Respiratory Medicine Units. The aim of the present prospective study was to investigate lung involvement in UCTD patients admitted to a Rheumatology Unit. Eighty-one consecutive UCTD patients were enrolled in the study. Each patient underwent history and physical examination, routine laboratory investigations, antinuclear antibody (ANA) profiling, B-mode echocardiography, and lung function study according to previously reported methods...
August 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28559797/regulation-of-the-hippocampal-network-by-vglut3-positive-cck-gabaergic-basket-cells
#19
Caroline Fasano, Jill Rocchetti, Katarzyna Pietrajtis, Johannes-Friedrich Zander, Frédéric Manseau, Diana Y Sakae, Maya Marcus-Sells, Lauriane Ramet, Lydie J Morel, Damien Carrel, Sylvie Dumas, Susanne Bolte, Véronique Bernard, Erika Vigneault, Romain Goutagny, Gudrun Ahnert-Hilger, Bruno Giros, Stéphanie Daumas, Sylvain Williams, Salah El Mestikawy
Hippocampal interneurons release the inhibitory transmitter GABA to regulate excitation, rhythm generation and synaptic plasticity. A subpopulation of GABAergic basket cells co-expresses the GABA/glycine vesicular transporters (VIAAT) and the atypical type III vesicular glutamate transporter (VGLUT3); therefore, these cells have the ability to signal with both GABA and glutamate. GABAergic transmission by basket cells has been extensively characterized but nothing is known about the functional implications of VGLUT3-dependent glutamate released by these cells...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28509682/new-neurosurgical-approaches-for-tremor-and-parkinson-s-disease
#20
Alfonso Fasano, Andres M Lozano, Esther Cubo
PURPOSE OF REVIEW: The objective of this review is to gather the newest advances in the surgical treatment of tremor and Parkinson's disease. We will briefly discuss the potential applications of the new technologies of deep brain stimulation (DBS), and we will focus on MRI-guided focused ultrasound (MRgFUS). RECENT FINDINGS: Novel DBS devices are being progressively adopted, particularly electrodes allowing a longer stimulating surface (suitable for multiple targets stimulation) and current radial steering (to minimize side effects of stimulation)...
August 2017: Current Opinion in Neurology
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