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https://www.readbyqxmd.com/read/28076984/percutaneous-endoscopic-gastrostomy-body-weight-loss-and-survival-in-amyotrophic-lateral-sclerosis-a-population-based-registry-study
#1
Antonio Fasano, Nicola Fini, Diana Ferraro, Laura Ferri, Marco Vinceti, Jessica Mandrioli
OBJECTIVE: To assess the role of percutaneous endoscopic gastrostomy (PEG) insertion, and its timing, on ALS survival, and to study prognostic factors of survival before and after PEG placement in a population-based setting. METHODS: In this observational population-based, registry study, we enrolled patients with newly- diagnosed ALS, according to the El Escorial revised criteria, who were resident in the Emilia Romagna Region, and who developed severe dysphagia needing enteral nutritional support...
January 11, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/28069576/dysbiosis-and-zonulin-upregulation-alter-gut-epithelial-and-vascular-barriers-in-patients-with-ankylosing-spondylitis
#2
Francesco Ciccia, Giuliana Guggino, Aroldo Rizzo, Riccardo Alessandro, Michele Maria Luchetti, Simon Milling, Laura Saieva, Heleen Cypers, Tommaso Stampone, Paola Di Benedetto, Armando Gabrielli, Alessio Fasano, Dirk Elewaut, Giovanni Triolo
BACKGROUND: Dysbiosis has been recently demonstrated in patients with ankylosing spondylitis (AS) but its implications in the modulation of intestinal immune responses have never been studied. The aim of this study was to investigate the role of ileal bacteria in modulating local and systemic immune responses in AS. METHODS: Ileal biopsies were obtained from 50 HLA-B27(+) patients with AS and 20 normal subjects. Silver stain was used to visualise bacteria. Ileal expression of tight and adherens junction proteins was investigated by TaqMan real-time (RT)-PCR and immunohistochemistry...
January 9, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28068393/facial-emotion-recognition-and-expression-in-parkinson-s-disease-an-emotional-mirror-mechanism
#3
Lucia Ricciardi, Federica Visco-Comandini, Roberto Erro, Francesca Morgante, Matteo Bologna, Alfonso Fasano, Diego Ricciardi, Mark J Edwards, James Kilner
BACKGROUND AND AIM: Parkinson's disease (PD) patients have impairment of facial expressivity (hypomimia) and difficulties in interpreting the emotional facial expressions produced by others, especially for aversive emotions. We aimed to evaluate the ability to produce facial emotional expressions and to recognize facial emotional expressions produced by others in a group of PD patients and a group of healthy participants in order to explore the relationship between these two abilities and any differences between the two groups of participants...
2017: PloS One
https://www.readbyqxmd.com/read/28034662/the-perspective-of-celiac-disease-patients-on-emerging-treatment-options-and-non-celiac-gluten-sensitivity
#4
Thomas Greuter, Sandra Schmidlin, Jaqueline Lattmann, Matthias Stotz, Romina Lehmann, Jonas Zeitz, Michael Scharl, Benjamin Misselwitz, Daniel Pohl, Michael Fried, Radu Tutuian, Alessio Fasano, Alain M Schoepfer, Gerhard Rogler, Luc Biedermann, Stephan R Vavricka
BACKGROUND: Non-celiac gluten sensitivity (NCGS) and emerging treatment options are hot topics in the celiac disease (CeD) scientific literature. However, very little is known about the perspective on these issues of CeD patients. METHODS: We performed a large patient survey among unselected CeD patients in Switzerland. RESULTS: A total of 1689 patients were analyzed. 57.5% have previously heard of NCGS. 64.5% believe in the existence of this entity...
December 7, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28009063/lesions-causing-freezing-of-gait-localize-to-a-cerebellar-functional-network
#5
Alfonso Fasano, Simon E Laganiere, Susy Lam, Michael D Fox
OBJECTIVE: Freezing of gait is a disabling symptom in Parkinson's disease and related disorders, but the brain regions involved in symptom generation remain unclear. Here we analyze brain lesions causing acute onset freezing of gait to identify regions causally involved in symptom generation. METHODS: Fourteen cases of lesion-induced freezing of gait were identified from the literature and lesions were mapped to a common brain atlas. Because lesion-induced symptoms can come from sites connected to the lesion location, not just the lesion location itself, we also identified brain regions functionally connected to each lesion location...
December 23, 2016: Annals of Neurology
https://www.readbyqxmd.com/read/28004533/new-olfactometric-findings-in-parkinson-s-disease
#6
Giulio Cesare Passali, Francesco Bove, Lucrezia Vargiu, Anna Rita Bentivoglio, Roberta Anzivino, Eugenio De Corso, Jacopo Galli, Mario Rigante, Manlio Pandolfini, Bruno Sergi, Monica Giuliani, Francesca Cianfrone, Gaetano Paludetti, Alfonso Fasano
OBJECTIVES: to investigate in Parkinson's Disease affected patients a correlation between hyposmia and gastrointestinal dysfunction and their possible identical etiopathogenesis. DESIGN: retrospective cohort study. SETTING: ENT and Neurology departments (Gemelli Hospital, Rome, Italy). PARTICIPANTS: 78 patients with diagnosis of PD according to the UK Brain Bank criteria. INCLUSION CRITERIA: informed consent; olfactory testing executed; exclusion criteria: signs of dementia according to the DSM-IV criteria; Mini Mental State Examination score ≤ 26; head trauma; central neurological disorders, nasal or systemic diseases potentially affecting olfactory function...
December 22, 2016: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28003208/gut-permeability-obesity-and-metabolic-disorders-who-is-the-chicken-and-who-is-the-egg
#7
Alessio Fasano
No abstract text is available yet for this article.
January 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27999318/differential-gnss-and-vision-based-tracking-to-improve-navigation-performance-in-cooperative-multi-uav-systems
#8
Amedeo Rodi Vetrella, Giancarmine Fasano, Domenico Accardo, Antonio Moccia
Autonomous navigation of micro-UAVs is typically based on the integration of low cost Global Navigation Satellite System (GNSS) receivers and Micro-Electro-Mechanical Systems (MEMS)-based inertial and magnetic sensors to stabilize and control the flight. The resulting navigation performance in terms of position and attitude accuracy may not suffice for other mission needs, such as the ones relevant to fine sensor pointing. In this framework, this paper presents a cooperative UAV navigation algorithm that allows a chief vehicle, equipped with inertial and magnetic sensors, a Global Positioning System (GPS) receiver, and a vision system, to improve its navigation performance (in real time or in the post processing phase) exploiting formation flying deputy vehicles equipped with GPS receivers...
December 17, 2016: Sensors
https://www.readbyqxmd.com/read/27977048/expanding-water-base-tolerant-frustrated-lewis-pair-chemistry-to-alkylamines-enables-broad-scope-reductive-aminations
#9
Valerio Fasano, Michael J Ingleson
Lower Lewis acidity boranes demonstrate greater tolerance to combinations of water/strong Brønsted bases than B(C6 F5 )3 , this enables Si-H bond activation by a frustrated Lewis pair (FLP) mechanism to proceed in the presence of H2 O/alkylamines. Specifically, BPh3 has improved water tolerance in the presence of alkylamines as the Brønsted acidic adduct H2 O-BPh3 does not undergo irreversible deprotonation with aliphatic amines in contrast to H2 O-B(C6 F5 )3 . Therefore BPh3 is a catalyst for the reductive amination of aldehydes and ketones with alkylamines using silanes as reductants...
December 15, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27975833/bioassay-guided-identification-of-bioactive-protein-compounds-from-the-mediterranean-demosponge-tethya-meloni
#10
E Gentile, C N Marzano, T Latronico, A Fasano, R Rossano, G Corriero, G M Liuzzi
No abstract text is available yet for this article.
December 2016: Planta Medica
https://www.readbyqxmd.com/read/27957319/blood-brain-barrier-and-intestinal-epithelial-barrier-alterations-in-autism-spectrum-disorders
#11
Maria Fiorentino, Anna Sapone, Stefania Senger, Stephanie S Camhi, Sarah M Kadzielski, Timothy M Buie, Deanna L Kelly, Nicola Cascella, Alessio Fasano
BACKGROUND: Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene-environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood-brain barrier (BBB), can be part of the chain of events leading to these disorders...
2016: Molecular Autism
https://www.readbyqxmd.com/read/27936497/pro-inflammatory-cytokine-ifn%C3%AE-and-microbiome-derived-metabolites-dictate-epigenetic-switch-between-foxp3-isoforms-in-celiac-disease-regulation-of-foxp3-isoforms-in-celiac-disease
#12
Gloria Serena, Shu Yan, Stephanie Camhi, Shilpi Patel, Rosiane S Lima, Anna Sapone, Maureen M Leonard, Rupa Mukherjee, Barbara J Nath, Karen M Lammers, Alessio Fasano
Celiac disease (CD) is an autoimmune enteropathy triggered by gluten and characterized by a strong Th1/Th17 immune response in the small intestine. Treg cells are CD4(+) CD25(++) FOXP3(+) cells that regulate the immune response. Conversely to its counterpart, FOXP3 full length (FL), the alternatively spliced isoform FOXP3 Δ2 cannot properly down-regulate Th17 driven immune response. Since the active state of CD has been associated with impairments in Treg cell function, we aimed at determining whether imbalances between FOXP3 isoforms may be associated with the disease...
December 9, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27933935/anisotropic-conjugated-polymer-chain-conformation-tailors-the-energy-migration-in-nanofibers
#13
Andrea Camposeo, Ryan D Pensack, Maria Moffa, Vito Fasano, Davide Altamura, Cinzia Giannini, Dario Pisignano, Gregory D Scholes
Conjugated polymers are complex multichromophore systems, with emission properties strongly dependent on the electronic energy transfer through active subunits. Although the packing of the conjugated chains in the solid state is known to be a key factor to tailor the electronic energy transfer and the resulting optical properties, most of the current solution-based processing methods do not allow for effectively controlling the molecular order, thus making the full unveiling of energy transfer mechanisms very complex...
November 30, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27918479/tempters-and-gluten-free-diet
#14
EDITORIAL
Carlo Catassi, Alessio Fasano
n/a.
December 3, 2016: Nutrients
https://www.readbyqxmd.com/read/27913903/amyotrophic-lateral-sclerosis-and-myasthenia-gravis-association-or-chance-occurrence
#15
Silvia de Pasqua, Francesco Cavallieri, Roberto D'Angelo, Fabrizio Salvi, Nicola Fini, Roberto D'Alessandro, Rita Rinaldi, Antonio Fasano, Jessica Mandrioli
Very few cases of patients with myasthenia gravis (MG) who later developed amyotrophic lateral sclerosis (ALS) have been described, although some studies showed that significantly more cases than expected have ALS associated with a prior diagnosis of autoimmune diseases. Our aim was to investigate whether the association of ALS and MG was higher than expected in a population-based study and to describe the clinical features characterizing these patients. In Emilia Romagna Region of Italy, a prospective registry has been collecting all incident ALS cases since 1...
December 2, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27909522/safety-and-necessity-of-thermal-esophageal-probes-during-radiofrequency-ablation-for-the-treatment-of-atrial-fibrillation
#16
Antonio Fasano, Prof Emeritus, Luca Anfuso Md, Stefano Bozzi Md, Claudio Pandozi Prof
BACKGROUND: Radiofrequency ablation is extensively used to achieve pulmonary veins isolation for the cure of atrial fibrillation. Luminal esophageal temperature can be monitored by means of suitable probes to prevent the onset of lesions. OBJECTIVE: To compute the thermal field generated by the ablation, to investigate the interaction between the electromagnetic field and the probe sensors, and to provide a safe interpretation of the temperature detected by the probe, supported by clinical data...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27873569/establishing-a-standard-of-care-for-deep-brain-stimulation-centers-in-canada
#17
Michel Panisset, Marina Picillo, Nicolas Jodoin, Yu-Yan Poon, Alejandro Valencia-Mizrachi, Alfonso Fasano, Renato Munhoz, Christopher R Honey
During the "DBS Canada Day" symposium held in Toronto July 4-5, 2014, the scientific committee invited experts to share their knowledge regarding deep brain stimulation (DBS) management of movement disorders in three domains: (1) the programming algorithms, (2) the necessary team to run a neurosurgery program, and (3) the appropriate scales to better define in a more comprehensive fashion the effect of the brain surgery. Each presentation was followed by an open discussion, and this article reports on the conclusions of this meeting on these three questions...
November 22, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27869412/blood-lead-levels-in-children-aged-between-1-and-6-years-old-in-la-plata-argentina-identification-of-risk-factors-for-lead-exposure
#18
Enrique Martins, Ana Varea, Karina Hernández, Marisa Sala, Ana Girardelli, Victoria Fasano, Liliana Disalvo
INTRODUCTION: Lead has neurotoxic effects in children, even at a very low level in blood. The risk factors (RFs) for lead exposure have not been adequately identified in La Plata. The objectives of this study were to determine mean blood lead levels and identify RFs in children aged 1 to 6 years old living in La Plata and the outskirts. POPULATION AND METHODS: A cross-sectional study was conducted in children who attended primary health care centers for a health check-up...
December 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27867061/interaction-between-drd2-variation-and-sound-environment-on-mood-and-emotion-related-brain-activity
#19
T Quarto, M C Fasano, P Taurisano, L Fazio, L A Antonucci, B Gelao, R Romano, M Mancini, A Porcelli, R Masellis, K J Pallesen, A Bertolino, G Blasi, E Brattico
Sounds, like music and noise, are capable of reliably affecting individuals' mood and emotions. However, these effects are highly variable across individuals. A putative source of variability is genetic background. Here we explored the interaction between a functional polymorphism of the dopamine D2 receptor gene (DRD2 rs1076560, G>T, previously associated with the relative expression of D2S/L isoforms) and sound environment on mood and emotion-related brain activity. Thirty-eight healthy subjects were genotyped for DRD2 rs1076560 (G/G=26; G/T=12) and underwent functional magnetic resonance imaging (fMRI) during performance of an implicit emotion-processing task while listening to music or noise...
January 26, 2017: Neuroscience
https://www.readbyqxmd.com/read/27855918/determination-of-bpa-bpb-bpf-badge-and-bfdge-in-canned-energy-drinks-by-molecularly-imprinted-polymer-cleaning-up-and-uplc-with-fluorescence-detection
#20
Pasquale Gallo, Ilaria Di Marco Pisciottano, Francesco Esposito, Evelina Fasano, Gelsomina Scognamiglio, Gustavo Damiano Mita, Teresa Cirillo
A new method for simultaneous determination of five bisphenols in canned energy drinks by UPLC with fluorescence detection, after clean up on molecularly imprinted polymers, is herein described. The method was validated at two concentration levels, calculating trueness, repeatability and within-laboratory reproducibility, specificity, linearity of detector response, the limits of quantifications and the limits of detection for each bisphenol. The method is specific, reliable and very sensitive, allowing for determination of bisphenol F diglycidyl ether (BFDGE), bisphenol A (BPA), bisphenol B (BPB), bisphenol F (BPF) and bisphenol A diglycidyl ether (BADGE) down to 0...
April 1, 2017: Food Chemistry
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