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https://www.readbyqxmd.com/read/28423466/zonulin-transgenic-mice-show-altered-gut-permeability-and-increased-morbidity-mortality-in-the-dss-colitis-model
#1
Craig Sturgeon, Jinggang Lan, Alessio Fasano
Increased small intestinal permeability (IP) has been proposed to be an integral element, along with genetic makeup and environmental triggers, in the pathogenies of chronic inflammatory diseases (CIDs). We identified zonulin as a master regular of intercellular tight junctions linked to the development of several CIDs. We aim to study the role of zonulin-mediated IP in the pathogenesis of CIDs. Zonulin transgenic Hp2 mice (Ztm) were subjected to dextran sodium sulfate (DSS) treatment for 7 days, followed by 4-7 days' recovery and compared to C57Bl/6 (wild-type (WT)) mice...
April 19, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28373263/daratumumab-anti-cd38-induces-loss-of-cd38-on-red-blood-cells
#2
Harold C Sullivan, Christian Gerner-Smidt, Ajay K Nooka, Connie M Arthur, Louisa Thompson, Amanda Mener, Seema R Patel, Marianne Yee, Ross M Fasano, Cassandra D Josephson, Richard M Kaufman, John D Roback, Sagar Lonial, Sean R Stowell
No abstract text is available yet for this article.
April 3, 2017: Blood
https://www.readbyqxmd.com/read/28365199/outcomes-of-immature-oocytes-collected-from-ovarian-tissue-for-cryopreservation-in-adult-and-prepubertal-patients
#3
Giovanna Fasano, Julie Dechène, Raffaella Antonacci, Jamila Biramane, Anne-Sophie Vannin, Anne Van Langendonckt, Fabienne Devreker, Isabelle Demeestere
The efficiency of oocyte in-vitro maturation (IVM) and vitrification procedures after ex-vivo collection from ovarian tissue were assessed according to patient age, number of retrieved oocytes and tissue transport conditions. The combined procedure was performed in 136 patients: 130 adults (mean 27.6 ± 5.6 years) and six prepubertal girls (mean 8.7 ± 2.3 years). A higher mean number of oocytes were collected in girls compared with adults (11.5 ± 8.0 versus 3.8 ± 4.2, respectively, P < 0.001) but the percentage of degenerated oocytes was significantly higher in girls (35...
March 20, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28356988/complete-response-to-capecitabine-in-a-frail-elderly-patient-with-metastatic-colorectal-cancer-a-case-report
#4
Morena Fasano, Alessio Fabozzi, Guido Giordano, Filippo Venturini, Gaetano Aurilio, Flavia Cantile, Teresa Fabozzi, Vincenzo Ricci, Giuseppe Santabarbara, Floriana Morgillo, Fortunato Ciardiello, Ferdinando De Vita
The clinical management of frail, elderly patients affected by colorectal cancer (CRC) remains a subject of debate. The present study reports the case of an elderly man with metastatic CRC (mCRC) who was successfully treated with capecitabine. The patient survived for 29 months, thus highlighting its potential activity in terms of obtaining a complete response and high efficacy. A 77-year-old man presented with adenocarcinoma of the rectum with multiple and synchronous liver metastases, in addition to several comorbidities...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28334381/mirroring-the-social-aspects-of-speech-and-actions-the-role-of-the-insula
#5
G Di Cesare, M Marchi, A Errante, F Fasano, G Rizzolatti
Action and speech may take different forms, being expressed, for example, gently or rudely. These aspects of social communication, named vitality forms, have been little studied in neuroscience. In the present functional magnetic resonance imaging study, we investigated the role of insula in processing action and speech vitality forms. In speech runs, participants were asked to listen or imaging themselves to pronounce action verbs gently or rudely. In action runs, they were asked to observe or imaging themselves to perform actions gently or rudely...
March 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28323375/synthesis-and-optoelectronic-properties-of-hexa-peri-hexabenzoborazinocoronene
#6
Jacopo Dosso, Jonathan Tasseroul, Francesco Fasano, Davide Marinelli, Nicolas Biot, Andrea Fermi, Davide Bonifazi
The first rational synthesis of a BN-doped coronene derivative in which the central benzene ring has been replaced by a borazine core is described. This includes six C-C ring-closure steps that, through intramolecular Friedel-Crafts-type reactions, allow the stepwise planarization of the hexaarylborazine precursor. UV/Vis absorption, emission, and electrochemical investigations show that the introduction of the central BN core induces a dramatic widening of the HOMO-LUMO gap and an enhancement of the blue-shifted emissive properties with respect to its all-carbon congener...
March 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28295073/zeonex-pmma-microstructured-polymer-optical-fbgs-for-simultaneous-humidity-and-temperature-sensing
#7
Getinet Woyessa, Jens K M Pedersen, Andrea Fasano, Kristian Nielsen, Christos Markos, Henrik K Rasmussen, Ole Bang
In this Letter, we report for the first time, to the best of our knowledge, the fabrication and characterization of a Zeonex/PMMA microstructured polymer optical fiber (mPOF) Bragg grating sensor for simultaneous monitoring of relative humidity (RH) and temperature. The sensing element (probe) is based on two separate in-line fiber Bragg gratings (FBGs) inscribed in the fabricated mPOF. A root mean square deviation of 0.8% RH and 0.6°C in the range of 10%-90% RH and 20°C-80°C was found. The developed mPOFBG sensor constitutes an efficient route toward low-cost, easy-to-fabricate and compact multi-parameter sensing solutions...
March 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28276248/borazino-doped-polyphenylenes
#8
Davide Marinelli, Francesco Fasano, Btissam Najjari, Nicola Demitri, Davide Bonifazi
The divergent synthesis of two series of borazino-doped polyphenylenes, in which one or more aryl units are replaced by borazine rings, is reported for the first time, taking advantage of the decarbonylative [4 + 2] Diels-Alder cycloaddition reaction between ethynyl and tetraphenylcyclopentadienone derivatives. Because of the possibility of functionalizing the borazine core with different groups on the aryl substituents at the N and B atoms of the borazino core, we have prepared borazino-doped polyphenylenes featuring different doping dosages and orientations...
April 4, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28265655/hepatitis-c-virus-related-hepatic-myelopathy-after-treatment-with-sofosbuvir-and-ribavirin-a-case-report
#9
Lazzaro di Biase, Marina Picillo, Maria Eliza Freitas, Esther Bui, Alfonso Fasano
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28242563/pesticides-polychlorinated-biphenyls-and-polycyclic-aromatic-hydrocarbons-in-cerebrospinal-fluid-of-amyotrophic-lateral-sclerosis-patients-a-case-control-study
#10
Marco Vinceti, Federica Violi, Manolis Tzatzarakis, Jessica Mandrioli, Carlotta Malagoli, Elizabeth E Hatch, Nicola Fini, Antonio Fasano, Valerii N Rakitskii, Olga-Ioanna Kalantzi, Aristides Tsatsakis
Neurotoxic chemicals including several pesticides have been suggested to play a role in the etiology of amyotrophic lateral sclerosis (ALS). We investigated the relation between organochlorine pesticides and their metabolites (OCPs), polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) in the etiology of sporadic ALS, determining for the first time their levels in cerebrospinal fluid as indicator of antecedent exposure. We recruited 38 ALS patients and 38 controls referred to an Italian clinical center for ALS care, who underwent a lumbar puncture for diagnostic purposes between 1994-2013, and had 1mL of cerebrospinal fluid available for the determination of OCPs, PCBs and PAHs...
May 2017: Environmental Research
https://www.readbyqxmd.com/read/28237852/exploring-risk-factors-for-stuttering-development-in-parkinson-disease-after-deep-brain-stimulation
#11
Marina Picillo, Gustavo B Vincos, Francesco Sammartino, Andres M Lozano, Alfonso Fasano
BACKGROUND: Stuttering is a speech disorder with disruption of verbal fluency, occasionally present in Parkinson's disease (PD). PD co-incident stuttering may either worsen or improve after Deep Brain Stimulation (DBS). METHODS: Sixteen out of 453 PD patients (3.5%) exhibited stuttering after DBS (PD-S) and were compared with a group of patients without stuttering (PD-NS) using non-parametric statistics. RESULTS: After DBS, stuttering worsened in 3 out of 4 patients with co-incidental stuttering...
February 20, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28224621/laboratory-assessment-of-sudden-sensorineural-hearing-loss-a-case-control-study
#12
Tommaso Fasano, Thelma A Pertinhez, Lorenzo Tribi, Daniela Lasagni, Annalisa Pilia, Luigi Vecchia, Roberto Baricchi, Giovanni Bianchin
OBJECTIVES/HYPOTHESIS: Sudden sensorineural hearing loss (SSHL) is an otologic emergency that affects five to 30 subjects per 100,000/year. The cause of SSHL remains unknown or uncertain in 70% to 90% of cases, and treatment decisions are usually made without knowing the etiology. STUDY DESIGN: Prospective case-control study. METHODS: One hundred thirty-one idiopathic SSHL patients were recruited from January 2014 to June 2015 in concordance with the Statements of Clinical Practice Guideline and divided into groups according to the disease severity...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28219968/celiac-disease-gut-brain-axis-and-behavior-cause-consequence-or-merely-epiphenomenon
#13
Alessio Fasano
No abstract text is available yet for this article.
March 2017: Pediatrics
https://www.readbyqxmd.com/read/28186331/adult-motor-phenotype-differentiates-dravet-syndrome-from-lennox-gastaut-syndrome-and-links-scn1a-to-early-onset-parkinsonian-features
#14
Danah Aljaafari, Alfonso Fasano, Fábio A Nascimento, Anthony E Lang, Danielle M Andrade
Distinguishing adult patients with Lennox-Gastaut syndrome from those with Dravet syndrome is challenging. We have previously reported that patients with Dravet syndrome present a very peculiar motor phenotype. Here we sought to confirm that this association was not linked to the chronic use of antiepileptic drugs or the many lifetime seizures. To this aim, we studied 14 adult patients with Lennox-Gastaut syndrome and 14 adults with Dravet syndrome because both conditions share similar seizure severity. We found that antecollis and parkinsonian gait were significantly more common in the Dravet group, thus suggesting that these features are part of the Dravet syndrome adult phenotype...
March 2017: Epilepsia
https://www.readbyqxmd.com/read/28185829/a-systematic-review-of-the-literature-for-severity-predictors-in-children-with-sickle-cell-anemia
#15
Emily Riehm Meier, Ross M Fasano, Paul R Levett
All patients with HbSS (SCA) share the same genetic mutation but the clinical phenotype is variable and difficult to predict early in life. A reliable severity predictor would be invaluable toward directing therapeutic decisions in those patients at highest risk of SCA complications. A search of PubMed, Cochrane Clinical Trials Register, and Scopus was performed to determine which SCA severity predictors have been validated in pediatric patients. The full text of 94 of the 590 references identified was reviewed based on the title/abstract...
February 2, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/28179096/long-term-efficacy-and-safety-of-switching-from-lamivudine-adefovir-to-tenofovir-disoproxil-fumarate-in-virologically-suppressed-patients
#16
Massimo Fasano, Paolo Maggi, Armando Leone, Anna Volpe, Jose Ramon Fiore, Gioacchino Angarano, Teresa Antonia Santantonio
BACKGROUND AND AIM: Tenofovir disoproxil fumarate (TDF) is recommended as first-line monotherapy for nucleos(t)ide (NA)-naïve chronic hepatitis B (CHB) patients and as a second-line rescue therapy for NA-experienced patients with a previous treatment failure. However, data regarding the efficacy of TDF monotherapy in patients with lamivudine resistance (LAM-R) successfully treated with LAM+adefovir (ADV) are limited. Herein, the efficacy and safety of switching from LAM+ADV to TDF monotherapy in clinical practice have been evaluated...
January 16, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28163136/safety-and-effectiveness-of-a-12-week-course-of-sofosbuvir-and-simeprevir%C3%A2-%C3%A2-%C3%A2-ribavirin-in-hcv-infected-patients-with-or-without-hiv-infection-a-multicentre-observational-study
#17
MULTICENTER STUDY
Giuseppe Bruno, Annalisa Saracino, Claudia Fabrizio, Luigia Scudeller, Eugenio Milano, Raffaele Dell'Acqua, Nicoletta Ladisa, Massimo Fasano, Salvatore Minniti, Giovanni Buccoliero, Alessandra Tartaglia, Adele Giammario, Michele Milella, Gioacchino Angarano
The combination of sofosbuvir and simeprevir ± ribavirin (SOF + SMV ± RBV) for hepatitis C virus (HCV) treatment has been associated with high rates of sustained virological response (SVR). Few data are available regarding this regimen in HIV/HCV co-infected patients. This study evaluated the effectiveness and safety of a 12-week course of SOF + SMV ± RBV in a cohort of HCV monoinfected and HIV/HCV co-infected individuals. HCV-infected patients, with or without HIV infection, receiving a 12-week course of SOF + SMV ± RBV in four Italian centres from February to October 2015, were included in this retrospective observational study...
March 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28159311/intestinal-barrier-maturation-in-very-low-birthweight-infants-relationship-to-feeding-and-antibiotic-exposure
#18
Bushra Saleem, Adora C Okogbule-Wonodi, Alessio Fasano, Laurence S Magder, Jacques Ravel, Shiv Kapoor, Rose M Viscardi
OBJECTIVE: To test the hypothesis that feeding and antibiotic exposures affect intestinal barrier maturation in preterm infants, we serially measured intestinal permeability (IP) biomarkers in infants <33 weeks gestation (gestational age [GA]) during the first 2 weeks of life. STUDY DESIGN: Eligible infants <33 weeks GA were enrolled within 4 days of birth in a prospective study of IP biomarkers (NCT01756040). Study participants received the nonmetabolized sugars lactulose/rhamnose enterally on study days 1, 8, and 15 and lactulose/rhamnose were measured in urine by high-performance liquid chromatography...
April 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28156625/clinical-and-health-care-setting-of-patients-admitted-at-pain-control-center-hospice-of-solofra-a-feasibility-model-of-end-of-life-care-in-the-avellino-province-of-italy
#19
Carmela Fasano, Luisa M Rizzo, A M Strollo, Elena De Vinco, Vincenzo Landolfi, Elena Altieri, Mario Nicola Vittorio Ferrante, Sergio Canzanella, Giuseppe Servillo, Lucia Genua, Maddalena Zampi, Gaetano D'Onofrio
59 Background: The Pain Control Center Hospice of Solofra (Italy) is managed with a mixed public / private, the first experience in the Campania region.We have evaluated the treatment procedures and the clinical outcome to make a comparison by between 123 evaluable patients in palliative care in 2015 and 232 evaluable patients in the biennium 2012-2014. METHODS: The following characteristics: patient gender, mean hospitalization time, differentiation between cancer and non cancer patients, medical weapon use, venous access type, enteral and parenteral feeding, pain killer use,Karnofsky scale...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28122648/microbiota-transfer-therapy-alters-gut-ecosystem-and-improves-gastrointestinal-and-autism-symptoms-an-open-label-study
#20
Dae-Wook Kang, James B Adams, Ann C Gregory, Thomas Borody, Lauren Chittick, Alessio Fasano, Alexander Khoruts, Elizabeth Geis, Juan Maldonado, Sharon McDonough-Means, Elena L Pollard, Simon Roux, Michael J Sadowsky, Karen Schwarzberg Lipson, Matthew B Sullivan, J Gregory Caporaso, Rosa Krajmalnik-Brown
BACKGROUND: Autism spectrum disorders (ASD) are complex neurobiological disorders that impair social interactions and communication and lead to restricted, repetitive, and stereotyped patterns of behavior, interests, and activities. The causes of these disorders remain poorly understood, but gut microbiota, the 10(13) bacteria in the human intestines, have been implicated because children with ASD often suffer gastrointestinal (GI) problems that correlate with ASD severity. Several previous studies have reported abnormal gut bacteria in children with ASD...
January 23, 2017: Microbiome
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