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https://www.readbyqxmd.com/read/27909522/safety-and-necessity-of-thermal-esophageal-probes-during-radiofrequency-ablation-for-the-treatment-of-atrial-fibrillation
#1
Antonio Fasano, Prof Emeritus, Luca Anfuso Md, Stefano Bozzi Md, Claudio Pandozi Prof
BACKGROUND: Radiofrequency ablation is extensively used to achieve pulmonary veins isolation for the cure of atrial fibrillation. Luminal esophageal temperature can be monitored by means of suitable probes to prevent the onset of lesions. OBJECTIVE: To compute the thermal field generated by the ablation, to investigate the interaction between the electromagnetic field and the probe sensors, and to provide a safe interpretation of the temperature detected by the probe, supported by clinical data...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27873569/establishing-a-standard-of-care-for-deep-brain-stimulation-centers-in-canada
#2
Michel Panisset, Marina Picillo, Nicolas Jodoin, Yu-Yan Poon, Alejandro Valencia-Mizrachi, Alfonso Fasano, Renato Munhoz, Christopher R Honey
During the "DBS Canada Day" symposium held in Toronto July 4-5, 2014, the scientific committee invited experts to share their knowledge regarding deep brain stimulation (DBS) management of movement disorders in three domains: (1) the programming algorithms, (2) the necessary team to run a neurosurgery program, and (3) the appropriate scales to better define in a more comprehensive fashion the effect of the brain surgery. Each presentation was followed by an open discussion, and this article reports on the conclusions of this meeting on these three questions...
November 22, 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27869412/blood-lead-levels-in-children-aged-between-1-and-6-years-old-in-la-plata-argentina-identification-of-risk-factors-for-lead-exposure
#3
Enrique Martins, Ana Varea, Karina Hernández, Marisa Sala, Ana Girardelli, Victoria Fasano, Liliana Disalvo
INTRODUCTION: Lead has neurotoxic effects in children, even at a very low level in blood. The risk factors (RFs) for lead exposure have not been adequately identified in La Plata. The objectives of this study were to determine mean blood lead levels and identify RFs in children aged 1 to 6 years old living in La Plata and the outskirts. POPULATION AND METHODS: A cross-sectional study was conducted in children who attended primary health care centers for a health check-up...
December 1, 2016: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/27867061/interaction-between-drd2-variation-and-sound-environment-on-mood-and-emotion-related-brain-activity
#4
T Quarto, M C Fasano, P Taurisano, L Fazio, L A Antonucci, B Gelao, R Romano, M Mancini, A Porcelli, R Masellis, K J Pallesen, A Bertolino, G Blasi, E Brattico
Sounds, like music and noise, are capable of reliably affecting individuals' mood and emotions. However, these effects are highly variable across individuals. A putative source of variability is genetic background. Here we explored the interaction between a functional polymorphism of the dopamine D2 receptor gene (DRD2 rs1076560, G>T, previously associated with the relative expression of D2S/L isoforms) and sound environment on mood and emotion-related brain activity. Thirty-eight healthy subjects were genotyped for DRD2 rs1076560 (G/G=26; G/T=12) and underwent functional magnetic resonance imaging (fMRI) during performance of an implicit emotion-processing task while listening to music or noise...
November 17, 2016: Neuroscience
https://www.readbyqxmd.com/read/27855918/determination-of-bpa-bpb-bpf-badge-and-bfdge-in-canned-energy-drinks-by-molecularly-imprinted-polymer-cleaning-up-and-uplc-with-fluorescence-detection
#5
Pasquale Gallo, Ilaria Di Marco Pisciottano, Francesco Esposito, Evelina Fasano, Gelsomina Scognamiglio, Gustavo Damiano Mita, Teresa Cirillo
A new method for simultaneous determination of five bisphenols in canned energy drinks by UPLC with fluorescence detection, after clean up on molecularly imprinted polymers, is herein described. The method was validated at two concentration levels, calculating trueness, repeatability and within-laboratory reproducibility, specificity, linearity of detector response, the limits of quantifications and the limits of detection for each bisphenol. The method is specific, reliable and very sensitive, allowing for determination of bisphenol F diglycidyl ether (BFDGE), bisphenol A (BPA), bisphenol B (BPB), bisphenol F (BPF) and bisphenol A diglycidyl ether (BADGE) down to 0...
April 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27843613/mechanisms-of-resistance-to-egfr-targeted-drugs-lung-cancer
#6
REVIEW
Floriana Morgillo, Carminia Maria Della Corte, Morena Fasano, Fortunato Ciardiello
Despite the improvement in clinical outcomes derived by the introduction of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (EGFR-TKIs) in the treatment of patients with advanced non-small cell lung cancer (NSCLC) whose tumours harbour EGFR-activating mutations, prognosis remains unfavourable because of the occurrence of either intrinsic or acquired resistance. We reviewed the published literature and abstracts of oral and poster presentations from international conferences addressing EGFR-TKIs resistance mechanisms discovered in preclinical models and in patients with NSCLC...
2016: ESMO Open
https://www.readbyqxmd.com/read/27812756/a-prospective-evaluation-of-taste-in-parkinson-s-disease
#7
M J Ricatti, S Ottaviani, F Boschi, A Fasano, M Tinazzi, M P Cecchini
It is well known that Parkinson's disease is characterized by a variety of non-motor symptoms. A gustatory deficit is hypothesized to be one of them although few and only cross-sectional studies are available. The aim of our pilot study was to prospectively investigate the taste function in Parkinson's disease patients after some years from the first evaluation (mean follow-up 4.35 ± 0.49 years; time range 3.5-5.6 years). A group of 26 patients was re-examined (16 males and 10 females; mean age 70.9 ± 8...
November 3, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/27780294/n-methyl-benzothiazolium-salts-as-carbon-lewis-acids-for-si-h-%C3%AF-bond-activation-and-catalytic-de-hydrosilylation
#8
Michael Ingleson, Valerio Fasano, Liam Curless, James Radcliffe
N-Me-benzothiazolium salts are introduced as a new family of Lewis acids able to activate Si-H σ bonds. These carbon centered Lewis acids were demonstrated to have comparable Lewis acidity towards hydride as found for the triarylboranes widely used in Si-H σ bond activation. However, they display low Lewis acidity towards hard Lewis bases such as Et3PO and H2O in contrast to triarylboranes. The N-Me-benzothiazolium salts are effective catalysts for a range of hydrosilylation and dehydrosilylation reactions...
October 25, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27779784/pisa-syndrome-in-parkinson-s-disease-an-integrated-approach-from-pathophysiology-to-management
#9
REVIEW
Michele Tinazzi, Christian Geroin, Marialuisa Gandolfi, Nicola Smania, Stefano Tamburin, Francesca Morgante, Alfonso Fasano
Pisa syndrome was first described in 1972 in patients treated with neuroleptics. Since 2003, when it was first reported in patients with Parkinson's disease (PD), Pisa syndrome has progressively drawn the attention of clinicians and researchers. Although emerging evidence has partially clarified its prevalence and pathophysiology, the current debate revolves around diagnostic criteria and assessment and the effectiveness of pharmacological, surgical, and rehabilitative approaches. Contrary to initial thought, Pisa syndrome is common among PD patients, with an estimated prevalence of 8...
October 25, 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/27766631/pulmonary-dysfunction-in-thalassaemia-major-is-there-any-relationship-with-body-iron-stores
#10
Francesca Guidotti, Gioia Piatti, Alessia Marcon, Elena Cassinerio, Marianna Giuditta, Alberto Roghi, Valter Fasano, Dario Consonni, Maria Domenica Cappellini
Although pulmonary function abnormalities in thalassaemia major (TM) were described in 1980, the pathogenetic mechanism is not clear and data are contradictory, probably because of study heterogeneity and the multifactorial nature of the pathogenesis. We retrospectively analysed 73 adult TM patients to evaluate the prevalence of pulmonary dysfunction in adult TM and investigate relationships with iron load. All patients underwent body plethysmography and carbon monoxide diffusion (DLCO) was assessed in 63, in addition to blood tests, echocardiogram and T2* myocardial and liver magnetic resonance imaging...
October 21, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27746327/exposure-assessment-to-fumonisins-b1-b2-and-b3-through-consumption-of-gluten-free-foodstuffs-intended-for-people-affected%C3%A2-by%C3%A2-celiac-disease
#11
Francesco Esposito, Evelina Fasano, Gelsomina Scognamiglio, Antonio Nardone, Maria Triassi, Teresa Cirillo
Fumonisins are mycotoxins produced by Fusarium species and affecting maize crops. Some analogues of fumonisins are known for their toxic and possible carcinogenic effects on humans and animals. Because of their occurrence in corn-based food, diet is the main source of exposure to these mycotoxins, especially among people affected by celiac disease. Hence, the purpose of this paper was to evaluate the amount of fumonisins B1, B2 and B3 in maize-based products and to assess the exposure of people affected by celiac disease to fumonisins...
November 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27743838/deep-brain-stimulation-in-rare-inherited-dystonias
#12
Isabelle Beaulieu-Boire, Camila C Aquino, Alfonso Fasano, Yu-Yan Poon, Melanie Fallis, Antony E Lang, Mojgan Hodaie, Suneil K Kalia, Andres Lozano, Elena Moro
BACKGROUND: Rare causes of inherited movement disorders often present with a debilitating phenotype of dystonia, sometimes combined with parkinsonism and other neurological signs. Since these disorders are often resistant to medications, DBS may be considered as a possible treatment. METHODS: Patients with identified genetic diseases (ataxia-telangiectasia, chorea-achantocytosis, dopa-responsive dystonia, congenital nemaline myopathy, methylmalonic aciduria, neuronal ceroid lipofuscinosis, spinocerebellar ataxia types 2 and 3, Wilson's disease, Woodhouse-Sakati syndrome, methylmalonic aciduria, and X trisomy) and disabling dystonia underwent bilateral GPi DBS (bilateral thalamic Vim nucleus in 1 case)...
October 4, 2016: Brain Stimulation
https://www.readbyqxmd.com/read/27723618/-amblyomma-triste-and-amblyomma-tigrinum-acari-ixodidae-in-sympatry-in-santa-fe-province-argentina
#13
Valeria C Colombo, Leandro R Antoniazzi, Agustín A Fasano, Pablo M Beldomenico, Santiago Nava
The aim of this communication is to report, for the first time, the occurrence of Amblyomma triste in Santa Fe province, Argentina, and to add a new isolation place for Amblyomma tigrinum. Both species of ticks are vectors of Rickettsia parkeri, a spotted fever group rickettsia. Ticks were recovered from tourists in August 2014 and December 2015 at the Federico Wildermuth Foundation (31° 59'S, 61° 24'O), San Martin Department, Santa Fe province. Five adult ticks were morphologically identified as A. tigrinum (3 females and 1 male) and A...
2016: Medicina
https://www.readbyqxmd.com/read/27719855/functional-facial-and-tongue-movement-disorders
#14
A Fasano, M Tinazzi
Functional movement disorders (FMDs) affecting the eyelids, tongue, and other facial muscles are often underrecognized because their phenomenology has not been fully characterized. Nevertheless, these disorders are more common than previously thought. In this chapter we will discuss the phenomenology as well as the clinical and instrumental diagnosis of facial FMDs. Facial FMDs should be considered when a patient exhibits any combination of the following features: (1) fixed unilateral facial contractions, especially with lower lip, with or without ipsilateral jaw involvement, of maximal severity at onset; (2) inconsistent features such as changes in side and pattern during or between examination; (3) associated somatoform or nonphysiologic sensory or motor findings; (4) reduction or abolition of facial spasm with distraction; (5) response to suggestion or psychotherapy; (6) rapid onset and/or spontaneous remissions; and (7) normal neurologic examination...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27717567/a-new-generation-3d-ozone-face-free-air-controlled-exposure
#15
Elena Paoletti, Alessandro Materassi, Gianni Fasano, Yasutomo Hoshika, Giulia Carriero, Diana Silaghi, Ovidiu Badea
To artificially simulate the impacts of ground-level ozone (O3) on vegetation, ozone FACE (Free Air Controlled Exposure) systems are increasingly recommended. We describe here a new-generation, three-dimensional ozone FACE, with O3 diffusion through laser-generated micro-holes, pre-mixing of air and O3, O3 generator with integral oxygen generator, continuous (day/night) exposure and full replication. Based on three O3 levels and assumptions on the pre-industrial O3 levels, we describe principles to calculate relative yield/biomass and estimate impacts even at lower-than-ambient O3 levels...
October 4, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27701144/thermal-transport-phenomena-in-nanoparticle-suspensions
#16
Annalisa Cardellini, Matteo Fasano, Masoud Bozorg Bigdeli, Eliodoro Chiavazzo, Pietro Asinari
Nanoparticle suspensions in liquids have received great attention, as they may offer an approach to enhance thermophysical properties of base fluids. A good variety of applications in engineering and biomedicine has been investigated with the aim of exploiting the above potential. However, the multiscale nature of nanosuspensions raises several issues in defining a comprehensive modelling framework, incorporating relevant molecular details and much larger scale phenomena, such as particle aggregation and their dynamics...
December 7, 2016: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/27694935/interplay-between-hydrophilicity-and-surface-barriers-on-water-transport-in-zeolite-membranes
#17
Matteo Fasano, Thomas Humplik, Alessio Bevilacqua, Michael Tsapatsis, Eliodoro Chiavazzo, Evelyn N Wang, Pietro Asinari
A comprehensive understanding of molecular transport within nanoporous materials remains elusive in a broad variety of engineering and biomedical applications. Here, experiments and atomistic simulations are synergically used to elucidate the non-trivial interplay between nanopore hydrophilicity and surface barriers on the overall water transport through zeolite crystals. At these nanometre-length scales, these results highlight the dominating effect of surface imperfections with reduced permeability on the overall water transport...
October 3, 2016: Nature Communications
https://www.readbyqxmd.com/read/27690321/the-versatile-2-substituted-imidazoline-nucleus-as-a-structural-motif-of-ligands-directed-to-the-serotonin-5-ht1a-receptor
#18
Fabio Del Bello, Antonio Cilia, Antonio Carrieri, Domenico Claudio Fasano, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Laura Micheli, Carlo Santini, Eleonora Diamanti, Mario Giannella, Gianfabio Giorgioni, Valerio Mammoli, Corinne Dalila Paoletti, Riccardo Petrelli, Alessandro Piergentili, Wilma Quaglia, Maria Pigini
The involvement of the serotonin 5-HT1A receptor (5-HT1A -R) in the antidepressant effect of allyphenyline and its analogues indicates that ligands bearing the 2-substituted imidazoline nucleus as a structural motif interact with 5-HT1A -R. Therefore, we examined the 5-HT1A -R profile of several imidazoline molecules endowed with a common scaffold consisting of an aromatic moiety linked to the 2-position of an imidazoline nucleus by a biatomic bridge. Our aim was to discover other ligands targeting 5-HT1A -R and to identify the structural features favoring 5-HT1A -R interaction...
September 30, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27690129/biomarkers-of-environmental-enteropathy-inflammation-stunting-and-impaired-growth-in-children-in-northeast-brazil
#19
Richard L Guerrant, Alvaro M Leite, Relana Pinkerton, Pedro H Q S Medeiros, Paloma A Cavalcante, Mark DeBoer, Margaret Kosek, Christopher Duggan, Andrew Gewirtz, Jonathan C Kagan, Anna E Gauthier, Jonathan Swann, Jordi Mayneris-Perxachs, David T Bolick, Elizabeth A Maier, Marjorie M Guedes, Sean R Moore, William A Petri, Alexandre Havt, Ila F Lima, Mara de Moura Gondim Prata, Josyf C Michaleckyj, Rebecca J Scharf, Craig Sturgeon, Alessio Fasano, Aldo A M Lima
Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and predict its effects on growth and development. We therefore assessed fecal, urinary and systemic biomarkers of enteropathy and growth predictors in 375 6-26 month-old children with varying degrees of malnutrition (stunting or wasting) in Northeast Brazil. 301 of these children returned for followup anthropometry after 2-6m...
2016: PloS One
https://www.readbyqxmd.com/read/27670207/medical-management-of-parkinson-s-disease-after-initiation-of-deep-brain-stimulation
#20
Alfonso Fasano, Silke Appel-Cresswell, Mandar Jog, Mateusz Zurowkski, Sarah Duff-Canning, Melanie Cohn, Marina Picillo, Christopher R Honey, Michel Panisset, Renato Puppi Munhoz
In this review, we have gathered all the available evidence to guide medication management after deep brain stimulation (DBS) in Parkinson's disease (PD). Surprisingly, we found that almost no study addressed drug-based management in the postoperative period. Dopaminergic medications are usually reduced, but whether the levodopa or dopamine agonist is to be reduced is left to the personal preference of the treating physician. We have summarized the pros and cons of both approaches. No study on the management of cognitive problems after DBS has been done, and only a few studies have explored the pharmacological management of such DBS-resistant symptoms as voice (amantadine), balance (donepezil) or gait disorders (amantadine, methylphenidate)...
September 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
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