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https://www.readbyqxmd.com/read/28631862/thalamic-deep-brain-stimulation-for-orthostatic-tremor-a-multicenter-international-registry
#1
Aristide Merola, Alfonso Fasano, Anhar Hassan, Jill L Ostrem, Maria Fiorella Contarino, Mark Lyons, Joachim K Krauss, Marc E Wolf, Bryan T Klassen, Anne-Fleur van Rootselaar, Ignacio Regidor, Andrew P Duker, William Ondo, Jorge Guridi, Jens Volkmann, Aparna Wagle Shukla, George T Mandybur, Michael S Okun, Karsten Witt, Philip A Starr, Günther Deuschl, Alberto J Espay
BACKGROUND: We report the accumulated experience with ventral intermediate nucleus deep brain stimulation for medically refractory orthostatic tremor. METHODS: Data from 17 patients were reviewed, comparing presurgical, short-term (0-48 months), and long-term (≥48 months) follow-up. The primary end point was the composite activities of daily living/instrumental activities of daily living score. Secondary end points included latency of symptoms on standing and treatment-related complications...
June 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28629409/correlation-between-knowledge-on-transmission-and-prevention-of-hiv-sti-and-proficiency-in-condom-use-among-male-migrants-from-africa-and-middle-east-evaluated-by-a-condom-use-skills-score-using-a-wooden-penile-model
#2
Fabio Zoboli, Domenico Martinelli, Mariantonietta Di Stefano, Massimo Fasano, Rosa Prato, Teresa Antonia Santantonio, Jose' Ramòn Fiore
BACKGROUND: Migrants in Italy are prevalently young adults, with a higher risk of sexual transmitted infections (STI) and HIV infection. Promoting consistent as well as correct use of condoms could reduce failure rate due to their improper use. The aim of our study was to evaluate Condom Use Skills among a migrant population recently landed in Italy, hosted in a government center for asylum seekers. METHODS: The study sample was composed of 80 male migrants. Sanitary trained interviewers submitted a questionnaire to participants to investigate age, provenience, marital status, educational level and knowledge about transmission and prevention of HIV/STI...
June 19, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28624097/serum-zonulin-gut-permeability-and-the-pathogenesis-of-autism-spectrum-disorders-cause-effect-or-an-epiphenomenon
#3
EDITORIAL
Alessio Fasano, Ivor Hill
No abstract text is available yet for this article.
June 14, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28620861/testing-a-ratio-of-photosynthesis-to-o3-uptake-as-an-index-for-assessing-o3-induced-foliar-visible-injury-in-poplar-trees
#4
Yasutomo Hoshika, Elisa Carrari, Lu Zhang, Giulia Carriero, Sara Pignatelli, Gianni Fasano, Alessandro Materassi, Elena Paoletti
Visible foliar injury by ozone (ozone visible injury) is known as a biomarker to assess potential phytotoxicity of ozone. We investigated ozone visible injury in an ozone-sensitive poplar (Oxford clone) under a 2-year free-air controlled exposure (FACE) experiment and calculated three ozone indices (i.e., accumulative ozone exposure over 40 ppb during daylight hours (AOT40), phytotoxic ozone dose above a flux threshold of 0 nmol m(-2) s(-1) (POD0), and the cumulative value of the ratio of hourly ozone uptake to net photosynthesis (ΣU/P n ) to assess the critical level (CL) at the time of the first symptom onset of ozone visible injury...
June 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28608991/frustrated-lewis-pair-mediated-1-2-hydrocarbation-of-alkynes
#5
Michael Ingleson, Valerio Fasano, James Radcliffe, Liam Curless
Frustrated Lewis pair (FLP) chemistry enables a rare example of alkyne 1,2-hydrocarbation to be achieved using N-Me-acridinium salts as the carbon Lewis acid. This 1,2-hydrocarbation process does not proceed via a concerted mechanism as per alkyne syn-hydroboration, or via an intramolecular 1,3-hydride migration as operating in the only other reported alkyne 1,2-hydrocarbation reaction. Instead, in this work alkyne 1,2-hydrocarbation proceeds by a novel mechanism involving alkyne dehydrocarbation using a carbon Lewis acid based FLP to form the new C-C bond...
June 13, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28608578/cantharidin-inhibits-competitively-heme-fe-iii-binding-to-the-fa1-site-of-human-serum-albumin
#6
Fabio Polticelli, Loris Leboffe, Valentina Tortosa, Viviana Trezza, Gabriella Fanali, Mauro Fasano, Paolo Ascenzi
Cantharidin, a monoterpene isolated from the insect blister beetle, has long been used as a medicinal agent in the traditional Chinese medicine. Cantharidin inhibits a subgroup of serine/threonine phosphatases, thus inducing cell growth inhibition and cytotoxicity. Cantharidin has anticancer activity in vitro, since it is able of inducing p53-dependent apoptosis and double-strand breakage of DNA in cancer cells. Although the toxicity of cantharidin to the gastrointestinal and urinary tracts prevents its medical use, it is a promising lead compound for chemical modification to develop new anticancer therapeutics...
June 13, 2017: Journal of Molecular Recognition: JMR
https://www.readbyqxmd.com/read/28597132/lung-involvement-in-stable-undifferentiated-connective-tissue-diseases-a-rheumatology-perspective
#7
Antonella Riccardi, Rosaria Irace, Ilaria Di Stefano, Michele Iudici, Serena Fasano, Marialuisa Bocchino, Annalisa Capaccio, Alessandro Sanduzzi, Gabriele Valentini
Previous studies of the occurrence of interstitial lung disease (ILD) in undifferentiated connective tissue diseases (UCTD) were conducted in patients admitted to Respiratory Medicine Units. The aim of the present prospective study was to investigate lung involvement in UCTD patients admitted to a Rheumatology Unit. Eighty-one consecutive UCTD patients were enrolled in the study. Each patient underwent history and physical examination, routine laboratory investigations, antinuclear antibody (ANA) profiling, B-mode echocardiography, and lung function study according to previously reported methods...
June 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28559797/regulation-of-the-hippocampal-network-by-vglut3-positive-cck-gabaergic-basket-cells
#8
Caroline Fasano, Jill Rocchetti, Katarzyna Pietrajtis, Johannes-Friedrich Zander, Frédéric Manseau, Diana Y Sakae, Maya Marcus-Sells, Lauriane Ramet, Lydie J Morel, Damien Carrel, Sylvie Dumas, Susanne Bolte, Véronique Bernard, Erika Vigneault, Romain Goutagny, Gudrun Ahnert-Hilger, Bruno Giros, Stéphanie Daumas, Sylvain Williams, Salah El Mestikawy
Hippocampal interneurons release the inhibitory transmitter GABA to regulate excitation, rhythm generation and synaptic plasticity. A subpopulation of GABAergic basket cells co-expresses the GABA/glycine vesicular transporters (VIAAT) and the atypical type III vesicular glutamate transporter (VGLUT3); therefore, these cells have the ability to signal with both GABA and glutamate. GABAergic transmission by basket cells has been extensively characterized but nothing is known about the functional implications of VGLUT3-dependent glutamate released by these cells...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28509682/new-neurosurgical-approaches-for-tremor-and-parkinson-s-disease
#9
Alfonso Fasano, Andres M Lozano, Esther Cubo
PURPOSE OF REVIEW: The objective of this review is to gather the newest advances in the surgical treatment of tremor and Parkinson's disease. We will briefly discuss the potential applications of the new technologies of deep brain stimulation (DBS), and we will focus on MRI-guided focused ultrasound (MRgFUS). RECENT FINDINGS: Novel DBS devices are being progressively adopted, particularly electrodes allowing a longer stimulating surface (suitable for multiple targets stimulation) and current radial steering (to minimize side effects of stimulation)...
May 13, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28507183/longterm-hydroxychloroquine-therapy-and-low-dose-aspirin-may-have-an-additive-effectiveness-in-the-primary-prevention-of-cardiovascular-events-in-patients-with-systemic-lupus-erythematosus
#10
Serena Fasano, Luciana Pierro, Ilenia Pantano, Michele Iudici, Gabriele Valentini
OBJECTIVE: Systemic lupus erythematosus (SLE) is associated with an increased risk of cardiovascular disease (CVD). Thromboprophylaxis with low-dose aspirin (ASA) and hydroxychloroquine (HCQ) seems promising in SLE. We investigated the effects of HCQ cumulative dosages (c-HCQ) and the possible synergistic efficacy of ASA and HCQ in preventing a first CV event (CVE) in patients with SLE. METHODS: Patients consecutively admitted to our center who, at admission, satisfied the 1997 American College of Rheumatology and/or 2012 Systemic Lupus Collaborating Clinics classification criteria for SLE, and had not experienced any CVE, were enrolled...
May 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28503363/focused-ultrasound-for-essential-tremor-review-of-the-evidence-and-discussion-of-current-hurdles
#11
REVIEW
Mohammad Rohani, Alfonso Fasano
BACKGROUND: While there is no breakthrough progress in the medical treatment of essential tremor (ET), in the past decades several remarkable achievements happened in the surgical field, such as radiofrequency thalamotomy, thalamic deep brain stimulation, and gamma knife thalamotomy. The most recent advance in this area is magnetic resonance-guided focused ultrasound (MRgFUS). METHODS: The purpose of this review is to discuss the new developments and trials of MRgFUS in the treatment of ET and other tremor disorders...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28490642/split-arm-swinging-the-effect-of-arm-swinging-manipulation-on-inter-limb-coordination-during-walking
#12
Moshe Bondi, Gabi Zeilig, Ayala Bloch, Alfonso Fasano, Meir Plotnik
Human locomotion is defined by bilateral coordination of gait (BCG) and shared features with the fore-hind limb coordination of quadrupeds. The objective of the present study is to explore the influence of arm swinging (AS) on BCG. Sixteen young healthy individuals (eight females; eight right motor-dominant, eight left-motor dominant) participated. Participants performed 10 walking trials (2 min). In each of the trials AS was unilaterally manipulated (e.g., arm restriction, weight on the wrist) bilaterally manipulated, or not manipulated...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28472040/ultra-deep-sequencing-reveals-high-prevalence-and-broad-structural-diversity-of-hepatitis-b-surface-antigen-mutations-in-a-global-population
#13
Mikael Gencay, Kirsten Hübner, Peter Gohl, Anja Seffner, Michael Weizenegger, Dionysios Neofytos, Richard Batrla, Andreas Woeste, Hyon-Suk Kim, Gaston Westergaard, Christine Reinsch, Eva Brill, Pham Thi Thu Thuy, Bui Huu Hoang, Mark Sonderup, C Wendy Spearman, Stephan Pabinger, Jérémie Gautier, Giuseppina Brancaccio, Massimo Fasano, Teresa Santantonio, Giovanni B Gaeta, Markus Nauck, Wolfgang E Kaminski
The diversity of the hepatitis B surface antigen (HBsAg) has a significant impact on the performance of diagnostic screening tests and the clinical outcome of hepatitis B infection. Neutralizing or diagnostic antibodies against the HBsAg are directed towards its highly conserved major hydrophilic region (MHR), in particular towards its "a" determinant subdomain. Here, we explored, on a global scale, the genetic diversity of the HBsAg MHR in a large, multi-ethnic cohort of randomly selected subjects with HBV infection from four continents...
2017: PloS One
https://www.readbyqxmd.com/read/28470250/design-colloidal-particle-morphology-and-self-assembly-for-coating-applications
#14
REVIEW
Shan Jiang, Antony Van Dyk, Alvin Maurice, James Bohling, David Fasano, Stan Brownell
The progressive replacement of organic solvent-based coatings by waterborne latex polymer coatings has substantially renovated the coating industry, and generated huge environmental and health benefits. Today, on top of the continuing demand for higher performance and lower costs, the coating industry faces tighter regulation and higher sustainability standards. In addition, the new waterborne coatings have created unique opportunities and challenges in terms of fundamental understanding and research development...
May 4, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28452345/hmga1-amplifies-wnt-signalling-and-expands-the-intestinal-stem-cell-compartment-and-paneth-cell-niche
#15
Lingling Xian, Dan Georgess, Tait Huso, Leslie Cope, Amy Belton, Yu-Ting Chang, Wenyong Kuang, Qihua Gu, Xiaoyan Zhang, Stefania Senger, Alessio Fasano, David L Huso, Andrew J Ewald, Linda M S Resar
High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. Prior studies showed that Hmga1 drives hyperproliferation, aberrant crypt formation and polyposis in transgenic mice. Here we demonstrate that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and expand the ISC compartment. Hmga1 upregulates genes encoding both Wnt agonist receptors and downstream Wnt effectors. Hmga1 also helps to 'build' an ISC niche by expanding the Paneth cell compartment and directly inducing Sox9, which is required for Paneth cell differentiation...
April 28, 2017: Nature Communications
https://www.readbyqxmd.com/read/28423466/zonulin-transgenic-mice-show-altered-gut-permeability-and-increased-morbidity-mortality-in-the-dss-colitis-model
#16
Craig Sturgeon, Jinggang Lan, Alessio Fasano
Increased small intestinal permeability (IP) has been proposed to be an integral element, along with genetic makeup and environmental triggers, in the pathogenies of chronic inflammatory diseases (CIDs). We identified zonulin as a master regular of intercellular tight junctions linked to the development of several CIDs. We aim to study the role of zonulin-mediated IP in the pathogenesis of CIDs. Zonulin transgenic Hp2 mice (Ztm) were subjected to dextran sodium sulfate (DSS) treatment for 7 days, followed by 4-7 days' recovery and compared to C57Bl/6 (wild-type (WT)) mice...
June 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28373263/daratumumab-anti-cd38-induces-loss-of-cd38-on-red-blood-cells
#17
LETTER
Harold C Sullivan, Christian Gerner-Smidt, Ajay K Nooka, Connie M Arthur, Louisa Thompson, Amanda Mener, Seema R Patel, Marianne Yee, Ross M Fasano, Cassandra D Josephson, Richard M Kaufman, John D Roback, Sagar Lonial, Sean R Stowell
No abstract text is available yet for this article.
June 1, 2017: Blood
https://www.readbyqxmd.com/read/28365199/outcomes-of-immature-oocytes-collected-from-ovarian-tissue-for-cryopreservation-in-adult-and-prepubertal-patients
#18
Giovanna Fasano, Julie Dechène, Raffaella Antonacci, Jamila Biramane, Anne-Sophie Vannin, Anne Van Langendonckt, Fabienne Devreker, Isabelle Demeestere
The efficiency of oocyte in-vitro maturation (IVM) and vitrification procedures after ex-vivo collection from ovarian tissue were assessed according to patient age, number of retrieved oocytes and tissue transport conditions. The combined procedure was performed in 136 patients: 130 adults (mean 27.6 ± 5.6 years) and six prepubertal girls (mean 8.7 ± 2.3 years). A higher mean number of oocytes were collected in girls compared with adults (11.5 ± 8.0 versus 3.8 ± 4.2, respectively, P < 0.001) but the percentage of degenerated oocytes was significantly higher in girls (35...
March 20, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28356988/complete-response-to-capecitabine-in-a-frail-elderly-patient-with-metastatic-colorectal-cancer-a-case-report
#19
Morena Fasano, Alessio Fabozzi, Guido Giordano, Filippo Venturini, Gaetano Aurilio, Flavia Cantile, Teresa Fabozzi, Vincenzo Ricci, Giuseppe Santabarbara, Floriana Morgillo, Fortunato Ciardiello, Ferdinando De Vita
The clinical management of frail, elderly patients affected by colorectal cancer (CRC) remains a subject of debate. The present study reports the case of an elderly man with metastatic CRC (mCRC) who was successfully treated with capecitabine. The patient survived for 29 months, thus highlighting its potential activity in terms of obtaining a complete response and high efficacy. A 77-year-old man presented with adenocarcinoma of the rectum with multiple and synchronous liver metastases, in addition to several comorbidities...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28334381/mirroring-the-social-aspects-of-speech-and-actions-the-role-of-the-insula
#20
G Di Cesare, M Marchi, A Errante, F Fasano, G Rizzolatti
Action and speech may take different forms, being expressed, for example, gently or rudely. These aspects of social communication, named vitality forms, have been little studied in neuroscience. In the present functional magnetic resonance imaging study, we investigated the role of insula in processing action and speech vitality forms. In speech runs, participants were asked to listen or imaging themselves to pronounce action verbs gently or rudely. In action runs, they were asked to observe or imaging themselves to perform actions gently or rudely...
March 1, 2017: Cerebral Cortex
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