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https://www.readbyqxmd.com/read/28509682/new-neurosurgical-approaches-for-tremor-and-parkinson-s-disease
#1
Alfonso Fasano, Andres M Lozano, Esther Cubo
PURPOSE OF REVIEW: The objective of this review is to gather the newest advances in the surgical treatment of tremor and Parkinson's disease. We will briefly discuss the potential applications of the new technologies of deep brain stimulation (DBS), and we will focus on MRI-guided focused ultrasound (MRgFUS). RECENT FINDINGS: Novel DBS devices are being progressively adopted, particularly electrodes allowing a longer stimulating surface (suitable for multiple targets stimulation) and current radial steering (to minimize side effects of stimulation)...
May 13, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28507183/longterm-hydroxychloroquine-therapy-and-low-dose-aspirin-may-have-an-additive-effectiveness-in-the-primary-prevention-of-cardiovascular-events-in-patients-with-systemic-lupus-erythematosus
#2
Serena Fasano, Luciana Pierro, Ilenia Pantano, Michele Iudici, Gabriele Valentini
OBJECTIVE: Systemic lupus erythematosus (SLE) is associated with an increased risk of cardiovascular disease (CVD). Thromboprophylaxis with low-dose aspirin (ASA) and hydroxychloroquine (HCQ) seems promising in SLE. We investigated the effects of HCQ cumulative dosages (c-HCQ) and the possible synergistic efficacy of ASA and HCQ in preventing a first CV event (CVE) in patients with SLE. METHODS: Patients consecutively admitted to our center who, at admission, satisfied the 1997 American College of Rheumatology and/or 2012 Systemic Lupus Collaborating Clinics classification criteria for SLE, and had not experienced any CVE, were enrolled...
May 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28503363/focused-ultrasound-for-essential-tremor-review-of-the-evidence-and-discussion-of-current-hurdles
#3
REVIEW
Mohammad Rohani, Alfonso Fasano
BACKGROUND: While there is no breakthrough progress in the medical treatment of essential tremor (ET), in the past decades several remarkable achievements happened in the surgical field, such as radiofrequency thalamotomy, thalamic deep brain stimulation, and gamma knife thalamotomy. The most recent advance in this area is magnetic resonance-guided focused ultrasound (MRgFUS). METHODS: The purpose of this review is to discuss the new developments and trials of MRgFUS in the treatment of ET and other tremor disorders...
2017: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/28490642/split-arm-swinging-the-effect-of-arm-swinging-manipulation-on-inter-limb-coordination-during-walking
#4
Moshe Bondi, Gabi Zeilig, Ayala Bloch, Alfonso Fasano, Meir Plotnik
Human locomotion is defined by bilateral coordination of gait (BCG) and shared features with the fore-hind limb coordination of quadrupeds. The objective of the present study is to explore the influence of arm swinging (AS) on BCG. Sixteen young healthy individuals (eight females; eight right motor-dominant, eight left-motor dominant) participated. Participants performed 10 walking trials (2 min). In each of the trials AS was unilaterally manipulated (e.g., arm restriction, weight on the wrist) bilaterally manipulated, or not manipulated...
May 10, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28472040/ultra-deep-sequencing-reveals-high-prevalence-and-broad-structural-diversity-of-hepatitis-b-surface-antigen-mutations-in-a-global-population
#5
Mikael Gencay, Kirsten Hübner, Peter Gohl, Anja Seffner, Michael Weizenegger, Dionysios Neofytos, Richard Batrla, Andreas Woeste, Hyon-Suk Kim, Gaston Westergaard, Christine Reinsch, Eva Brill, Pham Thi Thu Thuy, Bui Huu Hoang, Mark Sonderup, C Wendy Spearman, Stephan Pabinger, Jérémie Gautier, Giuseppina Brancaccio, Massimo Fasano, Teresa Santantonio, Giovanni B Gaeta, Markus Nauck, Wolfgang E Kaminski
The diversity of the hepatitis B surface antigen (HBsAg) has a significant impact on the performance of diagnostic screening tests and the clinical outcome of hepatitis B infection. Neutralizing or diagnostic antibodies against the HBsAg are directed towards its highly conserved major hydrophilic region (MHR), in particular towards its "a" determinant subdomain. Here, we explored, on a global scale, the genetic diversity of the HBsAg MHR in a large, multi-ethnic cohort of randomly selected subjects with HBV infection from four continents...
2017: PloS One
https://www.readbyqxmd.com/read/28470250/design-colloidal-particle-morphology-and-self-assembly-for-coating-applications
#6
REVIEW
Shan Jiang, Antony Van Dyk, Alvin Maurice, James Bohling, David Fasano, Stan Brownell
The progressive replacement of organic solvent-based coatings by waterborne latex polymer coatings has substantially renovated the coating industry, and generated huge environmental and health benefits. Today, on top of the continuing demand for higher performance and lower costs, the coating industry faces tighter regulation and higher sustainability standards. In addition, the new waterborne coatings have created unique opportunities and challenges in terms of fundamental understanding and research development...
May 4, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/28452345/hmga1-amplifies-wnt-signalling-and-expands-the-intestinal-stem-cell-compartment-and-paneth-cell-niche
#7
Lingling Xian, Dan Georgess, Tait Huso, Leslie Cope, Amy Belton, Yu-Ting Chang, Wenyong Kuang, Qihua Gu, Xiaoyan Zhang, Stefania Senger, Alessio Fasano, David L Huso, Andrew J Ewald, Linda M S Resar
High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. Prior studies showed that Hmga1 drives hyperproliferation, aberrant crypt formation and polyposis in transgenic mice. Here we demonstrate that Hmga1 amplifies Wnt/β-catenin signalling to enhance self-renewal and expand the ISC compartment. Hmga1 upregulates genes encoding both Wnt agonist receptors and downstream Wnt effectors. Hmga1 also helps to 'build' an ISC niche by expanding the Paneth cell compartment and directly inducing Sox9, which is required for Paneth cell differentiation...
April 28, 2017: Nature Communications
https://www.readbyqxmd.com/read/28423466/zonulin-transgenic-mice-show-altered-gut-permeability-and-increased-morbidity-mortality-in-the-dss-colitis-model
#8
Craig Sturgeon, Jinggang Lan, Alessio Fasano
Increased small intestinal permeability (IP) has been proposed to be an integral element, along with genetic makeup and environmental triggers, in the pathogenies of chronic inflammatory diseases (CIDs). We identified zonulin as a master regular of intercellular tight junctions linked to the development of several CIDs. We aim to study the role of zonulin-mediated IP in the pathogenesis of CIDs. Zonulin transgenic Hp2 mice (Ztm) were subjected to dextran sodium sulfate (DSS) treatment for 7 days, followed by 4-7 days' recovery and compared to C57Bl/6 (wild-type (WT)) mice...
April 19, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28373263/daratumumab-anti-cd38-induces-loss-of-cd38-on-red-blood-cells
#9
Harold C Sullivan, Christian Gerner-Smidt, Ajay K Nooka, Connie M Arthur, Louisa Thompson, Amanda Mener, Seema R Patel, Marianne Yee, Ross M Fasano, Cassandra D Josephson, Richard M Kaufman, John D Roback, Sagar Lonial, Sean R Stowell
No abstract text is available yet for this article.
April 3, 2017: Blood
https://www.readbyqxmd.com/read/28365199/outcomes-of-immature-oocytes-collected-from-ovarian-tissue-for-cryopreservation-in-adult-and-prepubertal-patients
#10
Giovanna Fasano, Julie Dechène, Raffaella Antonacci, Jamila Biramane, Anne-Sophie Vannin, Anne Van Langendonckt, Fabienne Devreker, Isabelle Demeestere
The efficiency of oocyte in-vitro maturation (IVM) and vitrification procedures after ex-vivo collection from ovarian tissue were assessed according to patient age, number of retrieved oocytes and tissue transport conditions. The combined procedure was performed in 136 patients: 130 adults (mean 27.6 ± 5.6 years) and six prepubertal girls (mean 8.7 ± 2.3 years). A higher mean number of oocytes were collected in girls compared with adults (11.5 ± 8.0 versus 3.8 ± 4.2, respectively, P < 0.001) but the percentage of degenerated oocytes was significantly higher in girls (35...
March 20, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28356988/complete-response-to-capecitabine-in-a-frail-elderly-patient-with-metastatic-colorectal-cancer-a-case-report
#11
Morena Fasano, Alessio Fabozzi, Guido Giordano, Filippo Venturini, Gaetano Aurilio, Flavia Cantile, Teresa Fabozzi, Vincenzo Ricci, Giuseppe Santabarbara, Floriana Morgillo, Fortunato Ciardiello, Ferdinando De Vita
The clinical management of frail, elderly patients affected by colorectal cancer (CRC) remains a subject of debate. The present study reports the case of an elderly man with metastatic CRC (mCRC) who was successfully treated with capecitabine. The patient survived for 29 months, thus highlighting its potential activity in terms of obtaining a complete response and high efficacy. A 77-year-old man presented with adenocarcinoma of the rectum with multiple and synchronous liver metastases, in addition to several comorbidities...
February 2017: Oncology Letters
https://www.readbyqxmd.com/read/28334381/mirroring-the-social-aspects-of-speech-and-actions-the-role-of-the-insula
#12
G Di Cesare, M Marchi, A Errante, F Fasano, G Rizzolatti
Action and speech may take different forms, being expressed, for example, gently or rudely. These aspects of social communication, named vitality forms, have been little studied in neuroscience. In the present functional magnetic resonance imaging study, we investigated the role of insula in processing action and speech vitality forms. In speech runs, participants were asked to listen or imaging themselves to pronounce action verbs gently or rudely. In action runs, they were asked to observe or imaging themselves to perform actions gently or rudely...
March 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28323375/synthesis-and-optoelectronic-properties-of-hexa-peri-hexabenzoborazinocoronene
#13
Jacopo Dosso, Jonathan Tasseroul, Francesco Fasano, Davide Marinelli, Nicolas Biot, Andrea Fermi, Davide Bonifazi
The first rational synthesis of a BN-doped coronene derivative in which the central benzene ring has been replaced by a borazine core is described. This includes six C-C ring-closure steps that, through intramolecular Friedel-Crafts-type reactions, allow the stepwise planarization of the hexaarylborazine precursor. UV/Vis absorption, emission, and electrochemical investigations show that the introduction of the central BN core induces a dramatic widening of the HOMO-LUMO gap and an enhancement of the blue-shifted emissive properties with respect to its all-carbon congener...
March 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28295073/zeonex-pmma-microstructured-polymer-optical-fbgs-for-simultaneous-humidity-and-temperature-sensing
#14
Getinet Woyessa, Jens K M Pedersen, Andrea Fasano, Kristian Nielsen, Christos Markos, Henrik K Rasmussen, Ole Bang
In this Letter, we report for the first time, to the best of our knowledge, the fabrication and characterization of a Zeonex/PMMA microstructured polymer optical fiber (mPOF) Bragg grating sensor for simultaneous monitoring of relative humidity (RH) and temperature. The sensing element (probe) is based on two separate in-line fiber Bragg gratings (FBGs) inscribed in the fabricated mPOF. A root mean square deviation of 0.8% RH and 0.6°C in the range of 10%-90% RH and 20°C-80°C was found. The developed mPOFBG sensor constitutes an efficient route toward low-cost, easy-to-fabricate and compact multi-parameter sensing solutions...
March 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28276248/borazino-doped-polyphenylenes
#15
Davide Marinelli, Francesco Fasano, Btissam Najjari, Nicola Demitri, Davide Bonifazi
The divergent synthesis of two series of borazino-doped polyphenylenes, in which one or more aryl units are replaced by borazine rings, is reported for the first time, taking advantage of the decarbonylative [4 + 2] Diels-Alder cycloaddition reaction between ethynyl and tetraphenylcyclopentadienone derivatives. Because of the possibility of functionalizing the borazine core with different groups on the aryl substituents at the N and B atoms of the borazino core, we have prepared borazino-doped polyphenylenes featuring different doping dosages and orientations...
April 4, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28265655/hepatitis-c-virus-related-hepatic-myelopathy-after-treatment-with-sofosbuvir-and-ribavirin-a-case-report
#16
Lazzaro di Biase, Marina Picillo, Maria Eliza Freitas, Esther Bui, Alfonso Fasano
No abstract text is available yet for this article.
March 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28242563/pesticides-polychlorinated-biphenyls-and-polycyclic-aromatic-hydrocarbons-in-cerebrospinal-fluid-of-amyotrophic-lateral-sclerosis-patients-a-case-control-study
#17
Marco Vinceti, Federica Violi, Manolis Tzatzarakis, Jessica Mandrioli, Carlotta Malagoli, Elizabeth E Hatch, Nicola Fini, Antonio Fasano, Valerii N Rakitskii, Olga-Ioanna Kalantzi, Aristides Tsatsakis
Neurotoxic chemicals including several pesticides have been suggested to play a role in the etiology of amyotrophic lateral sclerosis (ALS). We investigated the relation between organochlorine pesticides and their metabolites (OCPs), polychlorinated biphenyls (PCBs) and polycyclic aromatic hydrocarbons (PAHs) in the etiology of sporadic ALS, determining for the first time their levels in cerebrospinal fluid as indicator of antecedent exposure. We recruited 38 ALS patients and 38 controls referred to an Italian clinical center for ALS care, who underwent a lumbar puncture for diagnostic purposes between 1994-2013, and had 1mL of cerebrospinal fluid available for the determination of OCPs, PCBs and PAHs...
May 2017: Environmental Research
https://www.readbyqxmd.com/read/28237852/exploring-risk-factors-for-stuttering-development-in-parkinson-disease-after-deep-brain-stimulation
#18
Marina Picillo, Gustavo B Vincos, Francesco Sammartino, Andres M Lozano, Alfonso Fasano
BACKGROUND: Stuttering is a speech disorder with disruption of verbal fluency, occasionally present in Parkinson's disease (PD). PD co-incident stuttering may either worsen or improve after Deep Brain Stimulation (DBS). METHODS: Sixteen out of 453 PD patients (3.5%) exhibited stuttering after DBS (PD-S) and were compared with a group of patients without stuttering (PD-NS) using non-parametric statistics. RESULTS: After DBS, stuttering worsened in 3 out of 4 patients with co-incidental stuttering...
May 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28224621/laboratory-assessment-of-sudden-sensorineural-hearing-loss-a-case-control-study
#19
Tommaso Fasano, Thelma A Pertinhez, Lorenzo Tribi, Daniela Lasagni, Annalisa Pilia, Luigi Vecchia, Roberto Baricchi, Giovanni Bianchin
OBJECTIVES/HYPOTHESIS: Sudden sensorineural hearing loss (SSHL) is an otologic emergency that affects five to 30 subjects per 100,000/year. The cause of SSHL remains unknown or uncertain in 70% to 90% of cases, and treatment decisions are usually made without knowing the etiology. STUDY DESIGN: Prospective case-control study. METHODS: One hundred thirty-one idiopathic SSHL patients were recruited from January 2014 to June 2015 in concordance with the Statements of Clinical Practice Guideline and divided into groups according to the disease severity...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28219968/celiac-disease-gut-brain-axis-and-behavior-cause-consequence-or-merely-epiphenomenon
#20
Alessio Fasano
No abstract text is available yet for this article.
March 2017: Pediatrics
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