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Kallikrein

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https://www.readbyqxmd.com/read/29456540/kallikrein-kinin-system-suppresses-type-i-interferon-responses-a-novel-pathway-of-interferon-regulation
#1
Alecia Seliga, Michael Hweemoon Lee, Nicole C Fernandes, Viviana Zuluaga-Ramirez, Marta Didukh, Yuri Persidsky, Raghava Potula, Stefania Gallucci, Uma Sriram
The Kallikrein-Kinin System (KKS), comprised of kallikreins (klks), bradykinins (BKs) angiotensin-converting enzyme (ACE), and many other molecules, regulates a number of physiological processes, including inflammation, coagulation, angiogenesis, and control of blood pressure. In this report, we show that KKS regulates Type I IFN responses, thought to be important in lupus pathogenesis. We used CpG (TLR9 ligand), R848 (TLR7 ligand), or recombinant IFN-α to induce interferon-stimulated genes (ISGs) and proteins, and observed that this response was markedly diminished by BKs, klk1 (tissue kallikrein), or captopril (an ACE inhibitor)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29453640/effect-of-semi-rapid-maxillary-expansion-in-children-with-obstructive-sleep-apnea-syndrome-5-month-follow-up-study
#2
Saimir Hoxha, Ecem Kaya-Sezginer, Filiz Bakar-Ates, Oğuz Köktürk, Ufuk Toygar-Memikoğlu
BACKGROUND: The purpose of this study was to investigate the effect of semi-rapid maxillary expansion (SRME) orthodontic treatment on biomarkers and respiratory parameters in children with obstructive sleep apnea syndrome (OSAS) and maxillary transverse deficiency. METHODS: Thirty children with OSAS were included in this study. Fifteen children were enrolled as control, and 15 children were subjected to SRME orthodontic treatment method for 5 months. Beside respiratory parameters, pharyngeal area, dental arch, and postero-anterior widths and the levels of OSAS biomarkers in serum and urine were measured...
February 17, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29453042/evaluation-of-the-anti-hypertensive-effect-of-tengfu-jiangya-tablet-by-combination-of-uplc-q-exactive-ms-based-metabolomics-and-itraq-based-proteomics-technology
#3
Yanpeng Tian, Feng Jiang, Yunlun Li, Haiqiang Jiang, Yanjun Chu, Lijuan Zhu, Weixing Guo
OBJECTIVE: Tengfu Jiangya tablet (TJT) is a traditional Chinese medicine formulation composed of Uncaria rhynchophylla and Semen raphani. It is a hospital preparation that is widely used in clinics for treating hypertension. A previous metabolomics study reported that TJT exerted a protective effect on hypertension by restoring impaired NO production, ameliorating the inflammatory state, and vascular remodeling. A clinical proteomics study also revealed five key target proteins during TJT intervention...
February 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29442535/improving-the-understanding-of-plasma-kallikrein-contribution-to-arterial-thrombus-formation-using-two-plant-protease-inhibitors
#4
Bruno R Salu, Silvana Cristina Pando, Marlon V De Brito, André Fernando Medina, Frank Odei-Addo, Carminita Frost, Ryno Naude, Misako U Sampaio, Jonas Emsley, Francisco Humberto A Maffei, Maria Luiza V Oliva
The purpose of antithrombotic therapy is the prevention of thrombus formation and/or its extension with a minimum risk of bleeding. The inhibition of a variety of proteolytic processes, particularly those of the coagulation cascade, has been reported as a property of plant protease inhibitors. The role of trypsin inhibitors (TIs) from Delonix regia (Dr) and Acacia schweinfurthii (As), members of the Kunitz family of protease inhibitors, was investigated on blood coagulation, platelet aggregation, and thrombus formation...
February 14, 2018: Platelets
https://www.readbyqxmd.com/read/29435805/kallikrein-related-peptidase-6-klk6-expression-differentiates-tumor-subtypes-and-predicts-clinical-outcome-in-breast-cancer-patients
#5
Christoforos Haritos, Kleita Michaelidou, Konstantinos Mavridis, Ioannis Missitzis, Alexandros Ardavanis, John Griniatsos, Andreas Scorilas
Novel molecular markers that address the heterogeneity of breast cancer (BC) and provide meaningful prognostic information for BC patients are needed. Kallikrein-related peptidase 6 (KLK6) is aberrantly expressed and functionally implicated in BC and, like other members of the KLK family, may prove a useful molecular tool for clinical management. Our objective was to assess, for the first time, the clinical relevance of KLK6 mRNA expression in BC. Total RNA was isolated from 165 breast tumors, as well as 100 adjacent non-cancerous tumor specimens...
February 12, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29424931/calcium-signalling-in-the-acinar-environment-of-the-exocrine-pancreas-physiology-and-pathophysiology
#6
Oleksiy Gryshchenko, Julia V Gerasimenko, Shuang Peng, Oleg V Gerasimenko, Ole H Petersen
Physiological Ca 2+ signals in pancreatic acinar cells control fluid and enzyme secretion, whereas excessive Ca 2+ signals induced by pathological agents induce destructive processes leading to acute pancreatitis. Ca 2+ signals in the peri-acinar stellate cells may also play a role in the development of acute pancreatitis. In this study, we have explored Ca 2+ signalling in the different cell types to be found in the acinar environment of the pancreatic tissue. We have, for the first time, recorded depolarization-evoked Ca 2+ signals in pancreatic nerves and shown that whereas acinar cells receive a functional cholinergic innervation, there is no evidence for functional innervation of the stellate cells...
February 9, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29423395/plasma-prekallikrein-its-role-in-hereditary-angioedema-and-health-and-disease
#7
REVIEW
Alvin H Schmaier
Plasma prekallikrein (PK) has a critical role in acute attacks of hereditary angioedema (HAE). Unlike C1 inhibitor, its levels fall during HAE attacks with resultant cleaved high-molecular-weight kininogen. Cleavage of high-molecular-weight kininogen liberates bradykinin, the major biologic peptide that promotes the edema. How prekallikrein initially becomes activated in acute attacks of HAE is not known. PK itself is negatively associated with cardiovascular disease. High prekallikrein is associated with accelerated vascular disease in diabetes and polymorphisms of prekallikrein that reduce high-molecular-weight kininogen binding are associated with protection from cardiovascular events...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29408301/bradykinin-mediates-myogenic-differentiation-in-murine-myoblasts-through-the-involvement-of-sk1-spns2-s1p2-axis
#8
Gennaro Bruno, Francesca Cencetti, Caterina Bernacchioni, Chiara Donati, Kira Vanessa Blankenbach, Dominique Thomas, Dagmar Meyer Zu Heringdorf, Paola Bruni
Skeletal muscle tissue retains a remarkable regenerative capacity due to the activation of resident stem cells that in pathological conditions or after tissue damage proliferate and commit themselves into myoblasts. These immature myogenic cells undergo differentiation to generate new myofibers or repair the injured ones, giving a strong contribution to muscle regeneration. Cytokines and growth factors, potently released after tissue injury by leukocytes and macrophages, are not only responsible of the induction of the initial inflammatory response, but can also affect skeletal muscle regeneration...
February 2, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29406699/multifunctional-serine-protease-inhibitor-coated-water-soluble-gold-nanoparticles-as-a-novel-targeted-approach-for-the-treatment-of-inflammatory-skin-diseases
#9
David Limon, Maria Jose Fabrega, Ana C Calpena, Josefa Badía, Laura Baldoma, Lluïsa Pérez-García
The overexpression and increased activity of the serine protease Kallikrein 5 (KLK5) is characteristic of inflammatory skin diseases such as Rosacea. The use of inhibitors of this enzyme - such as 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF·HCl) or the anti-human recombinant Kallikrein 5 (anti-KLK5) antibody - in the treatment of the disease has been limited due to their low bioavailability, for which their immobilization in drug delivery agents can contribute to making serine protease inhibitors clinically useful...
February 6, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29399973/remote-limb-ischemic-postconditioning-promotes-motor-function-recovery-in-a-rat-model-of-ischemic-stroke-via-the-up-regulation-of-endogenous-tissue-kallikrein
#10
Dan Liang, Xi-Biao He, Zheng Wang, Ce Li, Bei-Yao Gao, Jun-Fa Wu, Yu-Long Bai
AIMS: Remote ischemic conditionings, such as pre- and per-conditioning, are known to provide cardioprotection in animal models of ischemia. However, little is known about the neuroprotection effect of postconditioning after cerebral ischemia. In this study, we aim to evaluate the motor function rescuing effect of remote limb ischemic postconditioning (RIPostC) in a rat model of acute cerebral stroke. METHODS: Left middle cerebral artery occlusion (MCAO) was performed to generate the rat model of ischemic stroke, followed by daily RIPostC treatment for maximum 21 days...
February 4, 2018: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/29397320/deciphering-defective-amelogenesis-using-in%C3%A2-vitro-culture-systems
#11
Dian Yosi Arinawati, Keiko Miyoshi, Ayako Tanimura, Taigo Horiguchi, Hiroko Hagita, Takafumi Noma
The conventional two-dimensional (2D) in vitro culture system is frequently used to analyze the gene expression with or without extracellular signals. However, the cells derived from primary culture and cell lines frequently deviate the gene expression profile compared to the corresponding in vivo samples, which sometimes misleads the actual gene regulation in vivo. To overcome this gap, we developed the comparative 2D and 3D in vitro culture systems and applied them to the genetic study of amelogenesis imperfecta (AI) as a model...
January 31, 2018: Journal of Bioscience and Bioengineering
https://www.readbyqxmd.com/read/29393333/a-65%C3%A2-gene-signature-for-prognostic-prediction-in-colon-adenocarcinoma
#12
Hui Jiang, Jun Du, Jiming Gu, Liugen Jin, Yong Pu, Bojian Fei
The aim of the present study was to examine the molecular factors associated with the prognosis of colon cancer. Gene expression datasets were downloaded from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus databases to screen differentially expressed genes (DEGs) between colon cancer samples and normal samples. Survival‑related genes were selected from the DEGs using the Cox regression method. A co‑expression network of survival‑related genes was then constructed, and functional clusters were extracted from this network...
January 18, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29393225/danhong-injection-protects-against-hypertension-induced-renal-injury-via-down-regulation-of-myoglobin-expression-in-spontaneously-hypertensive-rats
#13
John Owoicho Orgah, Miao Wang, Xiaohu Yang, Zhilong Wang, Dandan Wang, Qi Zhang, Guanwei Fan, Jihong Han, Gangjian Qin, Xiumei Gao, Yan Zhu
BACKGROUND/AIMS: High blood pressure is a major risk factor for chronic kidney disease. Currently, single-target anti-hypertensive drugs are not designed for high blood pressure-related organ damages. Danhong injection (DHI), made from the aqueous extracts of Radix Salviae miltiorrhizae and Flos Carthamus tinctorius, has various pharmacological effects, including BP lowering in SHR, mediated by the reduction of vascular remodeling and the up-regulation of Kallikrein-kinin system published recently by our team, yet if it renders renal protection remains unknown...
January 23, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29393149/redefining-the-phenotype-of-dental-caries
#14
Megan Weber, Jenny Bogstad Søvik, Aida Mulic, Kathleen Deeley, Anne B Tveit, Jessalyn Forella, Nicholas Shirey, Alexandre R Vieira
Dental caries is a multifactorial infectious disease and a major public health problem estimated to affect 60-90% of school children as well as a vast number of adults. The aim of this work was to define patterns of progression of the disease based on longitudinal data in contrast to using a cross-sectional assessment. dmft/DMFT scores were collected at ages 5, 12, 14, 16, 17, and 18 from 876 individuals. We tested our newly defined phenotypes for association with genetic variants in genes shown to be associated with caries...
January 25, 2018: Caries Research
https://www.readbyqxmd.com/read/29384112/dog-allergy-can-a-prevalent-or-exclusive-sensitization-to-can-f-5-be-considered-a-lucky-or-negative-event-in-real-life
#15
G Liccardi, L Calzetta, A Salzillo, G Apicella, A Piccolo, E Di Maro, P Rogliani
Recent studies have shown the increasing relevance of allergic sensitization to Can f 5 (a prostatic kallikrein), which is an androgen-regulated protein expressed in the prostate and detectable only in male dogs. Can f 5 can be a prevalent or exclusive sensitizing agent in a considerable percentage of dog-allergic patients. Its specific allergenic characteristics are able to induce possible negative as well as positive clinical effects in individuals sensitized to dogs. In the present article we pointed out the possible pros or cons of sensitization to this allergen in real life...
November 30, 2017: European Annals of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29378650/assessment-of-kallikrein-6-as-a-cross-sectional-and-longitudinal-biomarker-for-alzheimer-s-disease
#16
Kalicharan Patra, Antoninus Soosaipillai, Sigrid Botne Sando, Camilla Lauridsen, Guro Berge, Ina Møller, Gøril Rolfseng Grøntvedt, Geir Bråthen, Ilijana Begcevic, Simon Moussaud, Lennart Minthon, Oskar Hansson, Eleftherios P Diamandis, Linda R White, Henrietta M Nielsen
BACKGROUND: Kallikrein 6 (KLK6) is known to be an age-related protease expressed at high levels in the central nervous system. It was previously shown to be involved in proteolysis of extracellular proteins implicated in neurodegenerative diseases such as Alzheimer's disease (AD), prompting validation of KLK6 as a potential biomarker of disease. However, analyses of both plasma and cerebrospinal fluid (CSF) levels of KLK6 in patients with AD have been inconclusive. We present a detailed analysis of KLK6 in plasma and CSF in two separate cohorts in a cross-sectional and a longitudinal clinical setting...
January 29, 2018: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29366640/value-of-intact-prostate-specific-antigen-and-human-kallikrein-2-in-the-four-kallikrein-predictive-model-an-individual-patient-data-meta-analysis
#17
Andrew Vickers, Emily A Vertosick, Daniel D Sjoberg, Freddie Hamdy, David Neal, Anders Bjartell, Jonas Hugosson, Jenny L Donovan, Arnauld Villers, Stephen Zappala, Hans Lilja
PURPOSE: The four kallikrein panel, commercially available as the 4kScore, is a statistical model that has been shown to predict accurately both Gleason grade group ≥2 (high-grade) cancer on biopsy and long-term risk of distant prostate cancer metastases. The panel includes two novel markers, intact prostate specific antigen (PSA) and human kallikrein-related peptidase 2 (hK2). It has been questionned whether these two additional markers add discrimination to the clinical predictors (age, digital rectal exam, prior biopsy) and established molecular markers (total and free PSA)...
January 20, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29360776/involvement-of-bradykinin-b2-receptor-in-pathological-vascularization-in-oxygen-induced-retinopathy-in-mice-and-rabbit-cornea
#18
Erika Terzuoli, Lucia Morbidelli, Ginevra Nannelli, Antonio Giachetti, Sandra Donnini, Marina Ziche
The identification of components of the kallikrein-kinin system in the vitreous from patients with microvascular retinal diseases suggests that bradykinin (BK) signaling may contribute to pathogenesis of retinal vascular complications. BK receptor 2 (B2R) signaling has been implicated in both pro-inflammatory and pro-angiogenic effects promoted by BK. Here, we investigated the role of BK/B2R signaling in the retinal neovascularization in the oxygen-induced retinopathy (OIR) model. Blockade of B2R signaling by the antagonist fasitibant delayed retinal vascularization in mouse pups, indicating that the retinal endothelium is a target of the BK/B2R system...
January 23, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29357215/new-treatments-for-hereditary-angioedema
#19
Nathan M Johnson, Mariana A Phillips
Hereditary angioedema is characterized by severe, episodic edema of the subcutaneous and mucosal tissue. The disease carries significant morbidity and mortality due to involvement of the gastrointestinal tract and upper airway. Recent advances in the treatment of hereditary angioedema include new techniques used to isolate and purify human-derived C1 inhibitor, the production of a recombinant form of C1 inhibitor, and the development of drugs that target the kallikrein-kinin pathway. This paper reviews the mechanisms, efficacy, and adverse reactions associated with these medications...
January 2018: Skin Therapy Letter
https://www.readbyqxmd.com/read/29355711/implication-of-the-kallikrein-kinin-system-on-neurological-disorders-quest-for-potential-biomarkers-and-mechanisms
#20
REVIEW
Amaly Nokkari, Hadi Abou-El-Hassan, Yehia Mechref, Stefania Mondello, Mark S Kindy, Ayad A Jaffa, Firas Kobeissy
Neurological disorders represent major health concerns in terms of comorbidity and mortality worldwide. Despite a tremendous increase in our understanding of the pathophysiological processes involved in disease progression and prevention, the accumulated knowledge so far resulted in relatively moderate translational benefits in terms of therapeutic interventions and enhanced clinical outcomes. Aiming at specific neural molecular pathways, different strategies have been geared to target the development and progression of such disorders...
January 16, 2018: Progress in Neurobiology
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