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Kallikrein

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https://www.readbyqxmd.com/read/28221219/improving-the-evaluation-and-diagnosis-of-clinically-significant-prostate-cancer-in-2017
#1
Sigrid V Carlsson, Monique J Roobol
PURPOSE OF REVIEW: To provide an overview of the current state of the evidence and highlight recent advances in the evaluation and diagnosis of clinically significant prostate cancer, focusing on biomarkers, risk calculators and multiparametric MRI (mpMRI). RECENT FINDINGS: In 2017 there are numerous options to improve early detection as compared to a purely prostate-specific antigen (PSA)-based approach. All have strengths and drawbacks. In addition to repeating the PSA and performing clinical work-up (digital rectal examination and estimation of prostate volume), additional tests investigated in the initial biopsy setting are: %free PSA, Prostate Health Index, 4-kallikrein score, SelectMDx, and Michigan Prostate Score and in the repeat setting: %free PSA, Prostate Health Index, 4-kallikrein score, Prostate Cancer Antigen 3, and ConfirmMDx...
February 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28220244/resetting-of-renal-tissular-renin-angiotensin-and-bradykinin-kallikrein-systems-after-unilateral-kidney-denervation-in-rats
#2
Jürgen M Bohlender, Jürg Nussberger, Frédéric Birkhäuser, Eric Grouzmann, George N Thalmann, Hans Imboden
The renal tissular renin-angiotensin and bradykinin-kallikrein systems control kidney function together with the renal sympathetic innervation but their interaction is still unclear. To further elucidate this relationship, we investigated these systems in rats 6 days after left kidney denervation (DNX, n = 8) compared to sham-operated controls (CTR, n = 8). Plasma renin concentration was unchanged in DNX vs. CTR (p = NS). Kidney bradykinin (BK) and angiotensin (Ang) I and II concentrations decreased bilaterally in DNX vs...
February 20, 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28216900/trichosanthes-kirilowii-exerts-androgenic-activity-via-regulation-of-psa-and-klk2-in-22rv1-prostate-cancer-cells
#3
Soo-Jin Jeong, Ji-Yoon Choi, Mi-Sook Dong, Chang-Seob Seo, Hyeun-Kyoo Shin
BACKGROUND: The androgen comprises a group of hormones that play roles in male reproductive activity as well as personal characteristics. OBJECTIVE: We investigated the androgenic activity of various herbal medicines in human prostate cancer 22Rv1 cells. MATERIALS AND METHODS: Herbal extracts of Trichosanthes kirilowii (TK), Asarum sieboldii (AS), Sanguisorba officinalis (SO), and Xanthium strumarium (XS) were selected to have androgenic effects based on a preliminary in vitro screening system...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28197309/structure-guided-design-of-novel-potent-and-selective-macrocyclic-plasma-kallikrein-inhibitors
#4
Zhe Li, James Partridge, Abel Silva-Garcia, Peter Rademacher, Andreas Betz, Qing Xu, Hing Sham, Yunjin Hu, Yuqing Shan, Bin Liu, Ying Zhang, Haijuan Shi, Qiong Xu, Xubo Ma, Li Zhang
A series of macrocyclic analogues were designed and synthesized based on the cocrystal structure of small molecule plasma kallikrein (pKal) inhibitor, 2, with the pKal protease domain. This led to the discovery of a potent macrocyclic pKal inhibitor 29, with an IC50 of 2 nM for one olefinic isomer and 42.3 nM for the other olefinic isomer.
February 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28187111/plasma-kallikrein-dependent-transforming-growth-factor-%C3%AE-activation-in-patients-with-chronic-pancreatitis-and-pancreatic-cancer
#5
Ryutaro Teraoka, Mitsuko Hara, Kazuhiro Kikuta, Yoshiki Hirooka, Yutaka Furutani, Tooru Shimosegawa, Atsushi Masamune, Soichi Kojima
No abstract text is available yet for this article.
March 2017: Pancreas
https://www.readbyqxmd.com/read/28177876/long-intergenic-non-protein-coding-rna-00858-functions-as-a-competing-endogenous-rna-for-mir-422a-to-facilitate-the-cell-growth-in-non-small-cell-lung-cancer
#6
Shao-Ping Zhu, Jun-Yu Wang, Xian-Guo Wang, Jin-Ping Zhao
The expression of long non-coding RNAs (lncRNAs) is dysregulated in non-small cell lung cancer (NSCLC). However, the functions and contributions of lncRNAs remain largely unknown. Here, we identified a critical role of long intergenic non-protein coding RNA 00858 (LINC00858) in NSCLC. Ectopic expression of LINC00858 in NSCLC cells promoted cell proliferation and induced cell migration and invasion. Moreover, LINC00858 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-422a and thereby modulating the expression of kallikrein-related peptidase 4 (KLK4)...
February 6, 2017: Aging
https://www.readbyqxmd.com/read/28158215/in-silico-analyses-and-global-transcriptional-profiling-reveal-novel-putative-targets-for-pea3-transcription-factor-related-to-its-function-in-neurons
#7
Başak Kandemir, Ugur Dag, Burcu Bakir Gungor, İlknur Melis Durasi, Burcu Erdogan, Eray Sahin, Ugur Sezerman, Isil Aksan Kurnaz
Pea3 transcription factor belongs to the PEA3 subfamily within the ETS domain transcription factor superfamily, and has been largely studied in relation to its role in breast cancer metastasis. Nonetheless, Pea3 plays a role not only in breast tumor, but also in other tissues with branching morphogenesis, including kidneys, blood vasculature, bronchi and the developing nervous system. Identification of Pea3 target promoters in these systems are important for a thorough understanding of how Pea3 functions. Present study particularly focuses on the identification of novel neuronal targets of Pea3 in a combinatorial approach, through curation, computational analysis and microarray studies in a neuronal model system, SH-SY5Y neuroblastoma cells...
2017: PloS One
https://www.readbyqxmd.com/read/28150891/klk4-silencing-inhibits-the-growth-of-oral-squamous-cell-carcinoma-through-wnt-%C3%AE-catenin-signaling-pathway
#8
Zhi Cui, Ye Cui, Shuting Yang, Gan Luo, Yang Wang, Yixin Lou, Xinhua Sun
Oral squamous cell carcinoma (OSCC) is a malignancy that largely impacts the quality of people's daily life. Kallikrein-related peptidase 4 (KLK4) is highly expressed in OSCC, however, its roles in OSCC cells are unclear. In the present study, the effect of KLK4 silencing on the growth of OSCC cells was investigated. Our study showed that the proliferation and colony formation of OSCC cells was inhibited by KLK4 silencing and their cell cycle was arrested. Additionally, apoptosis of OSCC cells was enhanced by KLK4 silencing, with increased protein levels of cleaved PARP, cleaved caspase-3, Bax and decreased levels of Bcl-2...
February 2, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28142115/elevated-expression-of-klk8-predicts-poor-prognosis-in-colorectal-cancer
#9
Xianwu Liu, Bin Quan, Zhilong Tian, Hailin Xi, Gaolei Jia, Hui Wang, Liang Zhang, Ruming Liu, Cheng Ma, Fuzhou Han, Huansong Li, Fukang Yuan
KLK8, also known as neuropsin, is one of fifteen members of the human kallikrein-related peptidase (KLK) gene family, which consists of enzymes with serine protease enzymatic activity. Aberrant KLK8 expression has been reported in several malignancies. However, the clinicopathological significance and prognostic value of KLK8 expression in colorectal cancer (CRC) are unknown. Therefore, analysis of public datasets, quantitative real-time PCR and western blot analysis were performed to assess KLK8 expression in CRC at both the mRNA and protein level...
January 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28130211/plasma-kallikrein-mediates-brain-hemorrhage-and-edema-caused-by-tissue-plasminogen-activator-therapy-in-mice-after-stroke
#10
Fabrício Simão, Tuna Ustunkaya, Allen C Clermont, Edward P Feener
Thrombolytic therapy using tissue plasminogen activator (tPA) in acute stroke is associated with increased risks of cerebral hemorrhagic transformation and angioedema. While plasma kallikrein (PKal) has been implicated in contributing to both hematoma expansion and thrombosis in stroke, its role in the complications associated with the therapeutic use of tPA in stroke is not yet available. We investigated the effects of tPA on plasma prekallikrein (PPK) activation and the role of PKal on cerebral outcomes in a murine thrombotic stroke model treated with tPA...
January 27, 2017: Blood
https://www.readbyqxmd.com/read/28115917/a-new-enzyme-linked-immunosorbent-assay-elisa-for-human-free-and-bound-kallikrein-9
#11
Panagiota Filippou, Dimitrios Korbakis, Sofia Farkona, Antoninus Soosaipillai, Theano Karakosta, Eleftherios P Diamandis
BACKGROUND: Kallikrein 9 (KLK9) is a member of the human kallikrein-related peptidases family, whose physiological role and implications in disease processes remain unclear. The active form of the enzyme is predicted to have chymotryptic activity. In the present study, we produced for the first time the active recombinant protein and monoclonal antibodies, and developed novel immunoassays for the quantification of free and bound KLK9 in biological samples. METHODS: The coding sequence of mature KLK9 isoform (mat-KLK9) was expressed in an Expi293F mammalian system and the synthesized polypeptide was purified through a two-step protocol...
2017: Clinical Proteomics
https://www.readbyqxmd.com/read/28115185/plasma-kallikrein-enhances-platelet-aggregation-response-by-subthreshold-doses-of-adp
#12
Tatiana F Ottaiano, Sheila S Andrade, Cleide de Oliveira, Mariana C C Silva, Marcus V Buri, Maria A Juliano, Manoel J B C Girão, Misako U Sampaio, Alvin H Schmaier, Alexander Wlodawer, Francisco H A Maffei, Maria L V Oliva
Human plasma kallikrein (huPK) potentiates platelet responses to subthreshold doses of ADP, although huPK itself, does not induce platelet aggregation. In the present investigation, we observe that huPK pretreatment of platelets potentiates ADP-induced platelet activation by prior proteolysis of the G-protein-coupled receptor PAR-1. The potentiation of ADP-induced platelet activation by huPK is mediated by the integrin αIIbβ3 through interactions with the KGD/KGE sequence motif in huPK. Integrin αIIbβ3 is a cofactor for huPK binding to platelets to support PAR-1 hydrolysis that contributes to activation of the ADP signaling pathway...
January 20, 2017: Biochimie
https://www.readbyqxmd.com/read/28111174/a-systematic-review-and-meta-analysis-of-the-diagnostic-accuracy-of-prostate-health-index-and-4-kallikrein-panel-score-in-predicting-overall-and-high-grade-prostate-cancer
#13
REVIEW
Giorgio Ivan Russo, Federica Regis, Tommaso Castelli, Vincenzo Favilla, Salvatore Privitera, Raimondo Giardina, Sebastiano Cimino, Giuseppe Morgia
Markers for prostate cancer (PCa) have progressed over recent years. In particular, the prostate health index (PHI) and the 4-kallikrein (4K) panel have been demonstrated to improve the diagnosis of PCa. We aimed to review the diagnostic accuracy of PHI and the 4K panel for PCa detection. We performed a systematic literature search of PubMed, EMBASE, Cochrane, and Academic One File databases until July 2016. We included diagnostic accuracy studies that used PHI or 4K panel for the diagnosis of PCa or high-grade PCa...
December 30, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28103909/potential-diagnostic-biomarkers-for-chronic-kidney-disease-of-unknown-etiology-ckdu-in-sri-lanka-a-pilot-study
#14
Saravanabavan Sayanthooran, Dhammika N Magana-Arachchi, Lishanthe Gunerathne, Tilak Abeysekera
BACKGROUND: In Sri Lanka, there exists chronic kidney disease of both known (CKD) and unknown etiologies (CKDu). Identification of novel biomarkers that are customized to the specific causative factors would lead to early diagnosis and clearer prognosis of the diseases. This study aimed to find genetic biomarkers in blood to distinguish and identify CKDu from CKD as well as healthy populations from CKDu endemic and non-endemic areas of Sri Lanka. METHODS: The expression patterns of a selected panel of 12 potential genetic biomarkers were analyzed in blood using RT-qPCR...
January 19, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28103290/involvement-of-ddah-adma-nos-cgmp-and-cox-2-ptgis-camp-pathways-in-human-tissue-kallikrein-1-protecting-erectile-function-in-aged-rats
#15
Kai Cui, Yang Luan, Zhe Tang, Ke Rao, Tao Wang, Zhong Chen, Shaogang Wang, Jihong Liu, Daowen Wang
Our previous studies had reported that Human Tissue Kallikrein 1 (hKLK1) preserved erectile function in aged transgenic rats, while the detailed mechanism of hKLK1 protecting erectile function in aged rats through activation of cGMP and cAMP was not mentioned. To explore the latent mechanism, male wild-type Sprague-Dawley rats (WTR) and transgenic rats harboring the hKLK1 gene (TGR) were fed to 4 and 18 months old and divided into four groups: young WTR (yWTR) as the control, aged WTR (aWTR), aged TGR (aTGR) and aged TGRs with HOE140 (aTGRH)...
2017: PloS One
https://www.readbyqxmd.com/read/28093174/re-preserved-erectile-function-in-the-aged-transgenic-rat-harboring-human-tissue-kallikrein-1
#16
Allen D Seftel
No abstract text is available yet for this article.
February 2017: Journal of Urology
https://www.readbyqxmd.com/read/28088475/role-of-some-vasoactive-mediators-in-scorpion-envenomed-children-possible-relation-to-envenoming-outcome
#17
Sahar E M El-DeeK, Ayat A Sayed, Ahmed Y Nassar, Zeynab M Mohey-Eldeen, Hussein M Eldeeb, Abdel-Raheim M A Meki
Scorpion envenomation causes an autonomic storm resulting in changes in the vasoactive mediators' levels which lead to myocardial damage, cardiovascular disturbances, peripheral circulatory failure, pulmonary edema, multi-system-organ-failure and death. The study aimed to determine the circulating levels of adrenaline, noradrenaline, angiotensin converting enzyme (ACE), Angiotensin II (Ang II), kallikrein enzyme, nitric oxide (NO), aldosterone, and electrolytes Na(+), K(+) and Ca(+2) in scorpion envenomed children and to evaluate the potential relation between these vasoactive mediators, the severity of scorpion envenoming and the clinical outcome of envenomed children...
March 1, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28078811/the-effects-of-nanomaterials-on-blood-coagulation-in-hemostasis-and-thrombosis
#18
REVIEW
Jan Simak, Silvia De Paoli
The blood coagulation balance in the organism is achieved by the interaction of the blood platelets (PLTs) with the plasma coagulation system (PCS) and the vascular endothelial cells. In healthy organism, these systems prevent thrombosis and, in events of vascular damage, enable blood clotting to stop bleeding. The dysregulation of hemostasis may cause serious thrombotic and/or hemorrhagic pathologies. Numerous engineered nanomaterials are being investigated for biomedical purposes and are unavoidably exposed to the blood...
January 11, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/28069606/proteolytic-properties-of-single-chain-factor-xii-a-mechanism-for-triggering-contact-activation
#19
Ivan Ivanov, Anton Matafonov, Mao-Fu Sun, Qiufang Cheng, S Kent Dickeson, Ingrid M Verhamme, Jonas Emsley, David Gailani
When blood is exposed to variety of artificial surfaces and biologic substances, the plasma proteins factor XII (FXII) and prekallikrein undergo reciprocal proteolytic conversion to the proteases αFXIIa and α-kallikrein by a process called contact activation. These enzymes contribute to host-defense responses including coagulation, inflammation, and fibrinolysis. The initiating event in contact activation is debated. To test the hypothesis that single-chain FXII expresses activity that could initiate contact activation, we prepared human FXII variants lacking the Arg353 cleavage site required for conversion to αFXIIa (FXII-R353A), or lacking the three known cleavage sites at Arg334, Arg343, and Arg353 (FXII-T, for "triple" mutant), and compared their properties to wild type αFXIIa...
January 9, 2017: Blood
https://www.readbyqxmd.com/read/28065968/therapeutic-uses-of-pineapple-extracted-bromelain-in-surgical-care-a-review
#20
Zehra Abdul Muhammad, Tashfeen Ahmad
Bromelain is an extract obtained from the pineapple plant and is used as a traditional folk remedy for several ailments. In this review, a comprehensive electronic database search was carried out to compile available literature on therapeutic implications of bromelain. Pharmaceutical value of bromelain has been demonstrated in different surgical sub-specialties. Diverse biological processes like anti-inflammatory, anti-oedematous, analgesic, anti-thrombotic, exfoliation etc. are involved in bromelain's therapeutic actions, mediated through the kallikrein-kinin and arachidonic acid pathways as well as through effects on cell mediated immunity...
January 2017: JPMA. the Journal of the Pakistan Medical Association
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