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https://www.readbyqxmd.com/read/29125182/circulating-micrornas-as-potential-biomarkers-in-myasthenia-gravis-patients
#1
REVIEW
Anna Rostedt Punga, Tanel Punga
MicroRNAs (miRNAs) are small noncoding RNA molecules that bind to specific mRNA targets and regulate a wide range of important biological processes within cells. Circulating miRNAs are released into the extracellular space and can be measured in most biofluids, including blood serum and plasma. Recently, circulating miRNAs have emerged as easily accessible markers in various body fluids with different profiles and quantities specific for different human disorders, including autoimmune diseases. In myasthenia gravis (MG), diagnostic tests such as titers of serum autoantibodies specific for either the acetylcholine receptor (AChR(+) ) or muscle-specific tyrosine kinase (MuSK(+) ) do not necessarily reflect disease progression, and there is a great need for reliable objective biomarkers to monitor the disease course and therapeutic response...
November 10, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29124031/successful-lung-transplantation-in-a-patient-with-myasthenia-gravis
#2
Kangmin Kim, Hyun Joo Lee, Samina Park, Yoohwa Hwang, Young Whan Kim, Young Tae Kim
A 47-year-old man with myasthenia gravis (MG) was admitted for a lung transplant. He had bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantation due to acute myeloid leukemia. MG developed after stem cell transplantation. Bilateral sequential lung transplantations and a total thymectomy were performed. The patient underwent right diaphragmatic plication simultaneously due to preoperatively diagnosed right diaphragmatic paralysis. A tracheostomy was performed and bilevel positive airway pressure (BiPAP) was applied on postoperative days 8 and 9, respectively...
October 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29109003/prediction-of-postoperative-mechanical-ventilation-after-thymectomy-in-patients-with-myasthenia-gravis-a-myth-or-reality
#3
EDITORIAL
Javier H Campos
No abstract text is available yet for this article.
August 10, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29083502/a-clinical-predictive-score-for-postoperative-myasthenic-crisis
#4
Tetsuya Kanai, Akiyuki Uzawa, Yasunori Sato, Shigeaki Suzuki, Naoki Kawaguchi, Keiichi Himuro, Fumiko Oda, Yukiko Ozawa, Jin Nakahara, Norihiro Suzuki, Yuko K Takahashi, Satoru Ishibashi, Takanori Yokota, Takashi Ogawa, Kazumasa Yokoyama, Nobutaka Hattori, Shoko Izaki, Satoru Oji, Kyoichi Nomura, Juntaro Kaneko, Kazutoshi Nishiyama, Ichiro Yoshino, Satoshi Kuwabara
OBJECTIVE: Myasthenia gravis (MG) is an autoimmune disease mostly caused by autoantibodies against acetylcholine receptor associated with thymus abnormalities. Thymectomy has been proven to be an efficacious treatment for patients with MG, but postoperative myasthenic crisis often occurs and is a major complication. We aimed to develop and validate a simple scoring system based on clinical characteristics in the preoperative status to predict the risk of postoperative myasthenic crisis...
October 30, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29078684/thymic-minimally-invasive-surgery-state-of-the-art-across-the-world-central-south-america
#5
REVIEW
Ricardo Mingarini Terra
Literature suggests that, for thymectomy in myasthenia or resection of thymic tumors, minimally invasive surgery is equivalent to open surgery with regard to long-term outcomes. However, it could bring some benefits in the immediate results as complication rate or length-of-stay. There are doubts about the worldwide adoption of the method, though. In Latin America, the implementation of video-assisted thoracic surgery (VATS) started in the 1990s, but it progressed slowly. The main barriers were associated costs and training...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078679/thymic-mis-state-of-the-art-across-the-world-russian-federation
#6
REVIEW
Piotr Yablonskii, Grigorii Kudriashov, Vadim Pischik, Evgenii Sigal, Sabriddin Nuraliev
First VATS thymectomy was performed 25 years ago (Landreneau et al., 1992). After that, minimally invasive approaches for surgical procedures have rapidly increased in the world. The aim of this paper was study of current problems and the status of surgery for thymus diseases in Russia. This is first global survey of all thoracic centers, which had experience in thymic surgery.
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078673/the-results-of-video-assisted-thoracoscopic-thymectomies-in-saint-petersburg-russia-20-year-of-experience
#7
Piotr Yablonsky, Vadim Pischik, Marina G Tovbina, Mikhail Atiukov
BACKGROUND: During the period from 1996 to 2016, we have performed 281 thymectomies in patients with various diseases of the thymus. In 179 patients, thymic pathology was associated with autoimmune myasthenia gravis (MG), and, in 108 patients, thymoma was diagnosed. METHODS: The majority of surgeries [254] were performed using video thoracoscopy, 79 of them with an additional cervical approach. The long-term results of video thoracoscopic thymectomies in myasthenic patients were followed up for 1 to 15...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078661/definitions-and-standard-indications-of-minimally-invasive-techniques-in-thymic-surgery
#8
Marcin Zieliński
BACKGROUND: The minimally invasive thoracic procedures are those performed through the intercostal, subxiphoid, subcostal or transcervical incisions. In most of these procedures (with exception of some transcervical procedures) the video-assisted thoracic surgery (VATS) technique is used for performance of an operation under guidance of a video monitor. METHODS: According to the definition the minimally invasive procedures do not include the sternal manubriotomy (upper sternal split), transverse sternotomy and subcutaneous longitudinal sternotomy...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078658/minimally-invasive-surgical-procedures-for-thymic-disease-in-asia
#9
REVIEW
Meinoshin Okumura, Yasushi Shintani, Mitsunori Ohta, Yoshihisa Kadota, Masayoshi Inoue, Hiroyuki Shiono
Video-assisted thoracic surgery (VATS) procedures for thymic tumors and myasthenia gravis were introduced in Asia in the middle 1990s in at least two regions, Hong Kong and Japan. To overcome difficulties in obtaining a wide view of the anterior mediastinum, several methods for lifting the sternum or anterior chest wall have been presented, mainly by Japanese surgeons. More recently, single port VATS through a subxiphoid incision was also introduced in Japan. The long-term outcome of a VATS extended thymectomy for myasthenia gravis has been shown to be comparable to that of a trans-sternal extended thymectomy, while the long-term outcome of a VATS thymectomy for thymic epithelial tumors remains to be elucidated...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078646/extended-thymectomy-by-a-cervical-incision-additional-to-bilateral-vats-approach
#10
Liang Xue, Xuguang Pang, Yongxing Zhang, Jianyong Ding
BACKGROUND: Video-assisted thoracoscopic surgery (VATS) in thymectomy has shown safe and effective with many advantages in myasthenia gravis (MG) patients with or without thymoma than transsternal approach. This video aims to show the procedure of extended thymectomy via a cervical incision additional to bilateral VATS approach in a MG patient with an early stage thymoma. METHODS: The patient was a 46-year-old male who had onset of symptoms of blurred vision, dysarthria and dysphagia for 10 months before administration...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078638/subxiphoid-thymectomy-single-port-dual-port-and-robot-assisted
#11
Takashi Suda
Currently, surgical techniques that are less invasive than conventional median sternotomy are used for thymectomy in the treatment of myasthenia gravis and anterior mediastinal tumors as no sternal incision is required. We reported on a subxiphoid single-port thymectomy using CO2 insufflation, which has the following advantages: (I) the field of view offered by the camera scope inserted from the midline of the body helps confirm the location of the superior pole of the thymus and bilateral phrenic nerves; (II) there is minimal pain and no intercostal neuropathy occurs as intercostal spaces are not traversed; and (III) cosmetic outcomes are excellent...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078632/uniportal-bilateral-video-assisted-sequential-thoracoscopic-extended-thymectomy
#12
REVIEW
Francesco Paolo Caronia, Ettore Arrigo, Sebastiano Trovato, Attilio Ignazio Lo Monte, Salvatore Cottone, Francesco Sgalambro, Mario Guglielmo, Antonio Volpicelli, Alfonso Fiorelli
Standard video-assisted thoracoscopic surgery has been reported as a minimally invasive approach alternative to sternotomy for management of myasthenia gravis (MG) associated with thymoma or thymic hyperplasia. Uniportal video-thoracoscopy is an evolution of standard multi-portal video-thoracoscopy for management of several thoracic diseases but its role for resecting mediastinal tumor remains under-evaluated. Herein, we describe our experience with bilateral uniportal thoracoscopic sequential extended thymectomy with case and video illustrations...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078631/robotic-thymectomy
#13
REVIEW
Giuseppe Marulli, Giovanni Maria Comacchio, Federico Rea
Thymectomy is the most frequent surgical operation involving the mediastinum, both for the treatment of thymic tumors and for the multidisciplinary management of myasthenia gravis (MG). Different surgical approaches have been described, either traditional open approaches or minimally invasive ones. Robotic thymectomy represents a further step in the evolution of minimally invasive surgery. Available data show that robotic thymectomy may be considered a safe and feasible operation, with encouraging long-term results in myasthenic patients and promising results in patients with early stage thymoma, both in terms of surgical and oncological outcomes...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078630/robotic-thymectomy-a-new-approach-for-thymus
#14
REVIEW
Erkan Kaba, Tugba Cosgun, Kemal Ayalp, Mazen Rasmi Alomari, Alper Toker
Advancements in modern technology bring many evolutions in minimally invasive surgery such as robot assisted approaches. Because of complete resection is so important in thymectomy operations, they became a new era for robotic surgery as a result of its superiorities (intuitive movements, tremor filtration, more degrees of manipulative freedom, motion scaling, and high-definition stereoscopic vision).
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078617/surgical-and-oncological-outcomes-of-thoracoscopic-thymectomy-for-thymoma
#15
REVIEW
Makoto Odaka, You Tsukamoto, Takamasa Shibasaki, Shohei Mori, Hisatoshi Asano, Makoto Yamashita, Toshiaki Morikawa
Thymoma remains the most common primary anterior mediastinal neoplasm. Surgical resection remains central to the treatment of thymoma, with thoracoscopic thymectomy (TT) being increasingly performed. This present review article aimed to summarize current studies comparing TT and open thymectomy (OT). Recently, most patients with Masaoka stage I-II thymoma have been receiving TT. This procedure is associated with a significantly shorter post-operative hospital stay, decreased intraoperative blood loss, and fewer complications compared with OT...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078613/the-athens-uniportal-video-assisted-thoracic-surgery-masterclass-an-ambitious-kickstarter
#16
Constantine Marios Soultanis, Diego Gonzalez Rivas, Konstantinos Konstantinidis, Konstantinos Siafakas
The shift from open to minimally invasive techniques in thoracic surgery has been dramatic during the past 10 years. Not only the feasibility, safety, reproducibility and oncologic efficacy of these techniques have been clearly demonstrated, but also their superiority concerning mortality, postoperative pain, postoperative quality of life and recovery. Thus, video-assisted thoracic surgery (VATS) is currently the procedure of choice for a wide variety of thoracic interventions, ranging from major pulmonary resections for lung cancer to thymectomy and mediastinal procedures, even to esophageal procedures...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078610/left-video-assisted-thoracic-surgery-thymectomy
#17
REVIEW
Anee Sophia Jackson, Chris Devulapalli, Alexa Lowe, Abigael Bragado, Lorenzo De Marchi, M Blair Marshall
Video-assisted thoracic surgery (VATS) for the management of non-thymomatous myasthenia gravis (MG) as well as the management of small thymomas and other benign thymic pathology has been gaining in acceptance and popularity as an alternative to the traditional median sternotomy approach. Although VATS thymectomy has been described in several variations, our current preference is a left sided VATS approach due to the exposure it provides in critical areas of dissection. Here we describe our technique for the left sided VATS thymectomy including patient selection, preoperative preparation, operative steps, and postoperative care...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29078565/the-zakopane-pulmonary-hospital-experience-on-subxiphoid-thymectomy
#18
Marcin Zieliński, Mariusz Rybak, Katarzyna Solarczyk-Bombik, Michal Wilkojc, Wojciech Czajkowski, Sylweriusz Kosinski, Edward Fryzlewicz, Tomasz Nabialek, Malgorzata Szolkowska, Juliusz Pankowski
BACKGROUND: To present the technique of minimally invasive extended thymectomy performed through the subxiphoid-bilateral subcostal video-assisted thoracoscopic surgery (VATS) approach, with double elevation of the sternum for nonthymomatous myasthenia gravis (MG). METHODS: The whole dissection was performed through the 4-7 cm transverse subxiphoid incision with single 10 mm extra-long bariatric laparoscopy ports inserted subcostally to the right and left chest cavities for videothoracoscope and subsequently for chest tubes...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29073308/15-year-old-girl-with-aps-type-iiic-12-months-post-thymectomy-remission-of-myasthenia
#19
Milena Jamiołkowska, Artur Bossowski
Polyglandular autoimmune syndromes (PAS) is a group of heterogenous conditions characterized by the association of at least two organ-specific autoimmune disorders, concerning both endocrine and non-endocrine organs. Type III is defined as the combination of autoimmune thyroid disease and other autoimmune condition (other than Addison's disease) and is divided into four subtypes. We describe a teenage female patient - with the family history of autoimmune diseases, who has simultaneously developed the symptoms of autoimmune thyroid disease with the clinical picture of hyperthyroidism and myasthenia gravis at the age of fifteen...
2017: Pediatric Endocrinology, Diabetes, and Metabolism
https://www.readbyqxmd.com/read/29070772/coexisting-thymic-and-pulmonary-carcinoid-tumors-associated-with-multiple-endocrine-neoplasia-type1
#20
Makoto Motoishi, Kanna Horimoto, Kazuki Hayashi, Satoru Sawai, Koki Moriyoshi
An anterior mediastinal tumor was detected in a 45-year-old female during a medical checkup. Chest computed tomography (CT) showed the anterior mediastinal tumor and a pulmonary tumor in the right lower lobe. Furthermore, tumors of the parathyroid gland, pancreas, and pituitary gland were also detected. She was clinically diagnosed with multiple endocrine neoplasia type1 (MEN1). The patient underwent extended thymectomy combined with mediastinal lymph node dissection and wedge resection of the lung including the right pulmonary lesion via a median sternotomy...
October 26, 2017: Annals of Thoracic and Cardiovascular Surgery
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