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https://www.readbyqxmd.com/read/28097735/autoimmune-enteropathy-and-hepatitis-in-pediatric-heart-transplant-recipient
#1
Kimberly Lewis, Ryan Butts, J Antonio Quiros, Michelle Hudspeth, Katherine Twombley, Andrew Savage, Sally Self, Ali Burnette, Shaoli Sun
AIE is a rare disorder in children that presents with severe diarrhea and malabsorption, caused by immune-mediated damage to intestinal mucosa. AIE is often associated with various syndromes of immunodeficiency including IPEX syndrome (immune dysregulation, polyendocrinopathy and enteropathy, X-linked). Dysfunctional T regulatory cells are the source of pathology in both IPEX syndrome and AIE as they are essential in maintaining tolerance to self-antigens and eliminating autoreactive B cells. This case report describes a 10-year-old cardiac transplant and total thymectomy patient on chronic immunosuppression with tacrolimus that presented with AIE and extraintestinal manifestations of cyclical hepatitis...
January 17, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28066568/thymectomy-for-myasthenia-gravis-what-we-know-and-what-we-don-t
#2
EDITORIAL
Carlos E Bravo-Iñiguez, Michael T Jaklitsch
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28053696/invasive-thymoma-with-pure-red-cell-aplasia-and-amegakaryocytic-thrombocytopenia
#3
Takuya Onuki, Yusuke Kiyoki, Sho Ueda, Masatoshi Yamaoka, Seiich Shimizu, Masaharu Inagaki
We here describe a case involving a 67-yearold female patient who was referred to our hospital due to severe anemia (hemoglobin, 5.0 g/dL), thrombocytopenia (platelet count, 0.6 × 10(4)/μL), and a mediastinal shadow with calcification noted on X-ray. On admission, an anterior mediastinal tumor was detected, and bone marrow biopsy revealed few megakaryocytes and severely reduced numbers of erythroid cells. The diagnosis was thymoma with pure red cell aplasia (PRCA) and acquired amegakaryocytic thrombocytopenia (AAMT)...
November 2, 2016: Hematology Reports
https://www.readbyqxmd.com/read/28043477/thymectomy-for-myasthenia-gravis-complete-stable-remission-and-associated-prognostic-factors-in-over-1000-cases
#4
Andrew J Kaufman, Justin Palatt, Mark Sivak, Peter Raimondi, Dong-Seok Lee, Andrea Wolf, Fouad Lajam, Faiz Bhora, Raja M Flores
The efficacy of thymectomy and the optimal surgical technique in the treatment of myasthenia gravis (MG) remain controversial. Long-term outcomes are lacking and remission rates are based on small populations. We reviewed our institutional experience of thymectomy for MG focusing on long-term outcomes, complete stable remission (CSR), improvement of symptoms, after transcervical, transsternal, thoracotomy, and VATS thymectomy. A retrospective review of a prospectively maintained database of 3017 patients from 1941-2013 with MG was performed...
July 2016: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28040768/extrathymic-malignancies-associated-with-thymoma-a-forty-year-experience-at-a-single-institution
#5
Toshiko Kamata, Shigetoshi Yoshida, Hironobu Wada, Taiki Fujiwara, Hidemi Suzuki, Takahiro Nakajima, Takekazu Iwata, Yukio Nakatani, Ichiro Yoshino
OBJECTIVES: Patients with thymoma are reported to have an increased risk for developing second malignancies. The aim of this study was to assess the incidence of second malignancies among patients with thymoma. We focused especially on the impact that lung cancer has on survival in these patients. METHODS: Three hundred and thirty-five patients who underwent surgery for thymoma in Chiba University Hospital from January 1971 to November 2012 were included in this study...
December 31, 2016: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28024111/pleomorphic-rhabdomyosarcoma-arising-in-the-anterior-mediastinum-a-case-report-with-cytological-features-of-imprint-and-liquid-based-cytology-specimens
#6
Yoshimi Nishijima, Junko Hirato, Toshio Fukuda
We herein report the cytological features of a very rare case of pleomorphic rhabdomyosarcoma arising in the anterior mediastinum on imprint and liquid-based cytology (LBC) specimens. A 58-year-old man had an approximately 10-cm tumor in the anterior mediastinum as shown on computed tomography. Thymectomy with complete resection of the left lung was performed. The fresh cut surface of the tumor was used to prepare imprint and LBC specimens. The imprint specimens showed four types of tumor cells dispersed on a background of hemorrhage, necrosis, and mucus...
December 26, 2016: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28012741/analysis-of-tnf-related-apoptosis-inducing-ligand-and-receptors-and-implications-in-thymus-biology-and-myasthenia-gravis
#7
Irem Kanatli, Bahar Akkaya, Hilmi Uysal, Sevim Kahraman, Ahter Dilsad Sanlioglu
Myasthenia Gravis is an autoantibody-mediated, neuromuscular junction disease, and is usually associated with thymic abnormalities presented as thymic tumors (~10%) or hyperplastic thymus (~65%). The exact role of thymus in Myasthenia Gravis development is not clear, yet many patients benefit from thymectomy. The apoptotic ligand TNF-Related Apoptosis-Inducing Ligand is thought to be involved in the regulation of thymocyte counts, although conflicting results are reported. We investigated differential expression profiles of TNF-Related Apoptosis-Inducing Ligand and its transmembrane receptors, Nuclear Factor-kB activation status, and apoptotic cell counts in healthy thymic tissue and pathological thymus from Myasthenia Gravis patients...
November 4, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28008901/-the-role-of-plasmapheresis-in-prevention-of-complications-after-thoracoscopic-thymectomy-in-patients-with-myasthenia-combined-with-thymic-hyperplasia
#8
E I Sigal, A M Sigal, R E Sigal, M V Burmistrov, V R Bikbaeva
Surgical indications for thymectomy include thymus tumour of different genesis as well as myasthenia. Minimally invasive methods such as thorascopy and robot-assisted thymectomy have been widely used lately as well as standard surgical methods namely sternotomy and thoracotomy. Regardless the type of access in myasthenia patients specific crisis conditions of respiratory failure can appear in postoperative period that usually requires mechanical ventilation. This study was aimed to estimate the efficacy of pre- and postoperative plasmapheresis in prevention of specific myasthenia-associated complications...
2016: Khirurgiia
https://www.readbyqxmd.com/read/28007263/thymic-and-mediastinal-lymph-node-metastasis-of-colon-cancer
#9
Yoko Yamamoto, Ken Kodama, Yoshihito Ide, Masashi Takeda
Most anterior mediastinal tumors are thymomas. Thymic metastasis from other primary cancers is extremely rare. We report the case of a 72-year-old man who developed thymic and mediastinal lymph node metastases of cecum cancer. He had undergone laparoscopic ileocecal resection with regional lymph node dissection for primary cecum cancer 15 months previously. Follow-up computed tomography revealed tumors in the anterior mediastinum. Fluorodeoxyglucose positron emission tomography showed positive uptake in the tumors...
January 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27980781/critical-influence-of-the-thymus-on-peripheral-t-cell-homeostasis
#10
Pedro Henrique Oliveira Vianna, Fábio B Canto, Jeane S Nogueira, Caroline Fraga Cabral Gomes Nunes, Adriana César Bonomo, Rita Fucs
INTRODUCTION: A tight balance between regulatory CD4(+)Foxp3(+) (Treg) and conventional CD4(+)Foxp3(-) (Tconv) T cell subsets in the peripheral compartment, maintained stable throughout most of lifetime, is essential for preserving self-tolerance along with efficient immune responses. An excess of Treg cells, described for aged individuals, may critically contribute to their reported immunodeficiency. In this work, we investigated if quantitative changes in thymus emigration may alter the Treg/Tconv homeostasis regardless of the aging status of the peripheral compartment...
December 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27969512/ps01-46-robotic-thymectomy-early-stage-thymoma-and-non-tumor-benign-lesions-has-comparable-perioperative-outcomes-topic-surgery
#11
Mohamed Kamel, Mohamed Rahouma, Galal Ghaly, Abu Nasar, Brendon M Stiles, Nasser K Altorki, Jeffrey L Port
No abstract text is available yet for this article.
November 2016: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/27959595/randomized-trial-of-thymectomy-in-myasthenia-gravis
#12
LETTER
Michal Haran, Daniel Starobin, Ilana Schlesinger
No abstract text is available yet for this article.
17, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27959594/randomized-trial-of-thymectomy-in-myasthenia-gravis
#13
LETTER
Kristijonas Milinis
No abstract text is available yet for this article.
17, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27959593/randomized-trial-of-thymectomy-in-myasthenia-gravis
#14
LETTER
(no author information available yet)
No abstract text is available yet for this article.
17, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27956763/the-effect-of-immunonutrition-on-the-postoperative-complications-in-thymoma-with-myasthenia-gravis
#15
Yanzhong Xin, Hongfei Cai, Lihui Wu, Youbin Cui
Object. To test whether preoperative immunonutrition is efficacious in reducing postoperative complications in patients of thymoma with myasthenia gravis (MG). Material and Methods. A total of 244 patients operated on for thymoma with myasthenia gravis were prospectively assigned to two groups, each receiving seven-day preoperative and seven-day postoperative nutrition. The patients in immunonutrition group were given oral immunonutrition (IN). The patients in control group received oral standard nutrition...
2016: Mediators of Inflammation
https://www.readbyqxmd.com/read/27922503/myasthenia-gravis-and-lambert-eaton-myasthenic-syndrome
#16
Michael W Nicolle
PURPOSE OF REVIEW: This article discusses the pathogenesis, diagnosis, and management of autoimmune myasthenia gravis (MG) and Lambert-Eaton myasthenic syndrome (LEMS). RECENT FINDINGS: Recognition of new antigenic targets and improved diagnostic methods promise to improve the diagnosis of MG, although the clinical phenotypes associated with newer antibodies have not yet been defined. Future therapies might specifically target the aberrant immune response. The apparent increase in the prevalence of MG is not fully explained...
December 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27908939/l-shaped-mini-sternotomy-combined-with-videoscopic-approach-for-thymoma-with-invasion-of-major-veins
#17
Atsushi Suga, Shunsuke Yamada, Haruka Takeichi, Yusuke Nakamura, Masayuki Iwazaki
It might be possible to remove thymic tumors with minimal invasion of the left brachiocephalic vein (BCV) using an advanced videoscopic technique; simple resection of this vessel can be achieved via such an approach. However, tumor invasion of the superior vena cava or right  BCV requires angioplasty or reconstruction, both of which are difficult to perform in videoscopic procedures. We report a case of invasive thymoma with localized invasion of the great vessels at the junction of the left BCV and superior vena cava...
December 1, 2016: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/27904842/the-challenges-of-cardiothoracic-surgery-practice-in-nigeria-a-12-years-institutional-experience
#18
Bode Falase, Michael Sanusi, Adeola Animasahun, Ogadinma Mgbajah, Adetinuwe Majekodunmi, Onyekwelu Nzewi, Jonathan Nwiloh, David Oke
BACKGROUND: Although the specialty of cardiothoracic surgery has been practiced in Nigeria for many years, open heart surgery (OHS) has only in the last decade become relatively more frequent, mainly through visiting foreign cardiac surgical teams. At this early phase of development it is faced with multiple challenges, especially financing and local skilled manpower for which solutions have to be identified in order to ensure sustainability and future growth. This study is aimed at highlighting these obstacles to growth of cardiothoracic surgery based on our own institutional experience at Lagos State University Teaching Hospital (LASUTH) and the current status of OHS activity in other cardiothoracic centers in Nigeria...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27900082/successful-treatment-of-advanced-thymic-carcinoma-with-lymph-node-and-pleural-metastases-a-case-report
#19
Yoko Yamamoto, Ken Kodama, Tomohiro Maniwa, Hiroki Kishima
Thymic carcinoma is a rare type of cancer that is more aggressive and is associated with a poorer prognosis compared with thymoma. No definitive clinical management of this disease has been established to date. This report describes the 20-year clinical course of a 50-year-old male patient who was successfully treated for initially diagnosed stage IVb thymic carcinoma. Thymo-thymectomy combined with resection of the surrounding organs was performed on December 1995 with curative intent (R0) after neoadjuvant chemoradiotherapy...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27890878/prevalence-of-electrocardiographic-abnormalities-in-patients-with-myasthenia-gravis
#20
Jun Tsugawa, Masahiro Ogawa, Shinji Ouma, Jiro Fukae, Yoshio Tsuboi
OBJECTIVE: Myasthenia gravis (MG) is an immunological disorder of the neuromuscular junction, characterized by easy fatigability and weakness of the skeletal muscles. However, it has sometimes been reported that heart diseases including cardiomyopathies leading to sudden death have been observed in patients with MG. We studied the prevalence of electrocardiographic (ECG) abnormalities and heart disease in patients newly diagnosed with MG who had not received immunotherapy. METHODS: Fifty-three patients with MG were enrolled in our study...
November 25, 2016: Rinshō Shinkeigaku, Clinical Neurology
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