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https://www.readbyqxmd.com/read/28222414/urinary-steroid-metabolites-in-a-case-of-florid-ectopic-cushing-s-syndrome-and-clinical-correlations
#1
Angelos Kyriacou, Karolina G Stepien, Basil Issa
A 51-year old woman was admitted with multiple cerebral, pulmonary and intra-abdominal abscesses. The combination of apparent immunosuppression, obesity, diabetes mellitus, hypertension, hypokalaemia, osteoporotic fractures and bilateral shoulder avascular necrosis led to a clinical diagnosis of Cushing's syndrome (CS). This was biochemically confirmed as follows: midnight serum cortisol 4275 nmol/L (60-250), non-suppressed overnight dexamethasone suppression test, raised salivary cortisol 716 nmol/L (5-46) and ACTH 639 ng/L (0-46)...
October 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28219559/neovascularization-of-thymoma-from-left-internal-mammary-artery-bypass-graft
#2
Jordan Y Dubique, Harma Turbendian, Danny Chu
We present the case of a type AB thymoma in a 69-year-old man with previous coronary artery bypass grafting (CABG) in whom angiography revealed a left internal mammary artery graft supplying blood flow to a thymic neoplasm, which simultaneously occluded the graft. This required a redo sternotomy, lysis of pericardial adhesions, complete thymectomy, and redo one vessel off-pump CABG. This case seeks to sensitize physicians to the possibility of coronary adverse events in patients with a previous CABG in the setting of management of mediastinal neoplasms, and it presents the novel findings on cardiac imaging associated with this case...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28216655/a-novel-thymoma-associated-autoimmune-disease-anti-pit-1-antibody-syndrome
#3
Hironori Bando, Genzo Iguchi, Yasuhiko Okimura, Yukiko Odake, Kenichi Yoshida, Ryusaku Matsumoto, Kentaro Suda, Hitoshi Nishizawa, Hidenori Fukuoka, Atsuko Mokubo, Katsuyoshi Tojo, Yoshimasa Maniwa, Wataru Ogawa, Yutaka Takahashi
Anti-PIT-1 antibody syndrome has recently been reported and characterized by acquired growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies associated with autoimmunity to a pituitary specific transcription factor PIT-1, which plays an essential role in GH-, PRL-, and TSH-producing cells. Although circulating anti-PIT-1 antibody and PIT-1-reactive cytotoxic T cells (CTLs) were detected in the patients, the pathophysiology and precise mechanisms for the autoimmunity remain unclarified...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28216170/-thymomectomy-by-minimally-invasive-surgery-comparative-study-videosurgery-versus-robot-assisted-surgery
#4
A Witte Pfister, J-M Baste, N Piton, M Bubenheim, J Melki, A Wurtz, C Peillon
OBJECTIVES: To report the results of minimally invasive surgery in patients with stage I or II thymoma in the Masaoka classification. The reference technique is partial or complete thymectomy by sternotonomy. METHODS: A retrospective single-center study of a prospective database including all cases of thymoma operated from April 2009 to February 2015 by minimally invasive techniques: either videosurgery (VATS) or robot-assisted surgery (RATS). The surgical technique, type of resection, length of hospital stay, postoperative complications and recurrences were analysed...
February 16, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28186270/laparoscopic-transdiaphragmatic-thymectomy-without-chest-incisions
#5
Nkem Aziken, Maria Evasovich, Rafael S Andrade, Eitan Podgaetz
No abstract text is available yet for this article.
February 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28180109/multiple-thymoma-with-myasthenia-gravis
#6
Dong Hyun Seo, Sukki Cho
The actual incidence of multiple thymoma is unknown and rarely reported because it remains controversial whether the cases represent a disease of multicentric origin or a disease resulting from intrathymic metastasis. In this case, a patient underwent total thymectomy for multiple thymoma with myasthenia gravis via bilateral video-assisted thoracic surgery. A well-encapsulated multinodular cystic mass, measuring 57 mm×50 mm×22 mm in the right lobe of the thymus, and a well-encapsulated mass, measuring 32 mm×15 mm×14 mm in the left lobe, were found...
February 2017: Korean Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28166107/challenges-in-the-anesthetic-management-for-a-robotic-thymectomy-in-a-patient-with-myasthenia-gravis-a-case-report
#7
Susan M Martinelli, Bilal D Lateef, Jason M Long, David Y Huang, Ameeta Karmarkar, Brian P Barrick
We describe the case of a patient with myasthenia gravis undergoing a robotic-assisted thymectomy complicated by postoperative myasthenic crisis, with a focus on the anesthetic considerations specific to this case. Because myasthenia gravis is an autoimmune disease affecting acetylcholine receptors, caution must be taken with the use of neuromuscular blockade and reversal. Utilizing a robotic-assisted surgical approach makes anesthetic management challenging given the dangers of patient movement while the robot is docked, lung isolation, extubation criteria, and postoperative disposition...
February 3, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28154568/il-7-induced-proliferation-of-human-naive-cd4-t-cells-relies-on-continued-thymic-activity
#8
Susana L Silva, Adriana S Albuquerque, Paula Matoso, Bénédicte Charmeteau-de-Muylder, Rémi Cheynier, Dário Ligeiro, Miguel Abecasis, Rui Anjos, João T Barata, Rui M M Victorino, Ana E Sousa
Naive CD4 T-cell maintenance is critical for immune competence. We investigated here the fine-tuning of homeostatic mechanisms of the naive compartment to counteract the loss of de novo CD4 T-cell generation. Adults thymectomized in early childhood during corrective cardiac surgery were grouped based on presence or absence of thymopoiesis and compared with age-matched controls. We found that the preservation of the CD31(-) subset was independent of the thymus and that its size is tightly controlled by peripheral mechanisms, including prolonged cell survival as attested by Bcl-2 levels...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28149887/improved-outcomes-with-surgery-vs-medical-therapy-in-non-thymomatous-myesthenia-gravis-a-perspective-on-the-results-of-a-randomized-trial
#9
COMMENT
Olugbenga T Okusanya, Nick Hess, Neil Christie, James D Luketich, Inderpal S Sarkaria
Myasthenia gravis can be a debilitating neurological disorder that affects thousands worldwide. Thymectomy has historically been considered in patients refractory to medical therapy or with concurrent thymoma. While retrospective data and propensity matched trials have favored thymectomy in order to decrease disease severity and disease associated morbidity, no randomized data existed to clearly delineate the benefit of this practice. The reviewed paper by Wolfe et al. represents the first high-level randomized prospective study investigating the role of thymectomy in patients with non-thymomatous myasthenia gravis...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28149641/randomized-trial-of-thymectomy-in-myasthenia-gravis
#10
COMMENT
Gil I Wolfe, Henry J Kaminski, Joshua R Sonnett, Inmaculada B Aban, Hui-Chien Kuo, Gary R Cutter
No abstract text is available yet for this article.
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28149621/minimally-invasive-thymectomy-for-thymoma-does-surgical-approach-matter-or-is-it-a-question-of-stage
#11
EDITORIAL
Andrew J Kaufman, Raja M Flores
No abstract text is available yet for this article.
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28149591/non-intubated-subxiphoid-uniportal-video-assisted-thoracoscopic-thymectomy-using-glasses-free-3d-vision
#12
Long Jiang, Jun Liu, Wenlong Shao, Jingpei Li, Jianxing He
Trans-sternal thymectomy has long been accepted as the standard surgical procedure for thymic masses. Recently, minimally invasive methods, such as video-assisted thoracoscopic surgery (VATS) and, even more recently, non-intubated anesthesia, have emerged. These methods provide advantages including reductions in surgical trauma, postoperative associated pain, and in regards to VATS, provide certain cosmetic benefits. Considering these advantages, we herein present a case of subxiphoid uniportal VATS for thymic mass using a glasses-free 3D thoracoscopic display system...
December 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28148454/comparison-of-conservative-treatment-and%C3%A2-thymectomy-on-myasthenia-gravis%C3%A2-outcome
#13
Emanuela Taioli, Philip Kent Paschal, Bian Liu, Andrew J Kaufman, Raja M Flores
BACKGROUND: A systematic review of the literature was performed to compare long-term outcomes of thymectomy and medical treatment for generalized myasthenia gravis (MG). METHODS: A Medline search through June 2015 resulted in 71 studies, 27 of which were selected (10,140 patients: 5,275 thymectomies, 4,865 medication). RESULTS: The pooled proportion of remission with thymectomy was 0.31 (95% CI, 0.25-0.37), with conservative treatment it was 0...
December 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28147469/thymoma-and-synchronous-primary-mediastinal-seminomas-with-florid-follicular-lymphoid-hyperplasia-in-the-anterior-mediastinum-a-case-report-and-review-of-the-literature
#14
Hyang-Im Lee, In-Seok Jang, Kyung Nyeo Jeon, Gyung Hyuck Ko, Jong Sil Lee, Dong Chul Kim, Dae Hyun Song, Jeong-Hee Lee
Thymoma is the most common neoplasm of the anterior mediastinum and has malignant potential. Germ cell tumors (GCTs) found in the anterior mediastinum are usually benign, and malignant GCTs, such as seminomas, are rare. Histologically, mediastinal seminoma is indistinguishable from testicular seminoma except for site-associated morphological features such as lymphoid follicular hyperplasia. Therefore, excluding metastasis is very important. Recently, we treated a young adult patient with multiple thymic masses that occurred simultaneously...
February 2, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28126978/-the-significance-of-extended-thymectomy-in-non-thymomatous-myasthenia-gravis-an-mgtx-study
#15
Hiroaki Yoshikawa
In August 2016, the results of the international randomized, controlled, trial that studied the safety and efficacy of extended trans-sternal thymectomy (ETTX) for patients with non-thymomatous myasthenia gravis (MG) was published. The inclusion criteria for this study were: 1) male and female subjects aged>18.0 and <60.0 years with non-thymomatous MG; 2) MG Foundation of America (MGFA) Clinical Classification Class II-IV at entry; 3) anti-acetylcholine receptor antibody (AChRAb) positive; and 4) receiving optimal oral anticholinesterase treatment with or without oral prednisone...
January 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28121481/robotic-thymectomy-learning-curve-and-associated-perioperative-outcomes
#16
Mohamed K Kamel, Mohamed Rahouma, Brendon M Stiles, Abu Nasar, Nasser K Altorki, Jeffrey L Port
INTRODUCTION: Recently, robotic-assisted thymectomy (RAT) has emerged as an alternative to either, an open transsternal approach or to a video-assisted thoracoscopic approach, for both thymic tumors and benign lesions. We have reviewed our early experience with RAT to assess the associated learning curve as well as the short-term perioperative outcomes. METHODS: A prospectively collected database was reviewed for patients who underwent RAT for all causes in the period 2012-2016...
January 25, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28120786/thymectomy-the-more-you-know-the-more-you-know-you-don-t-know
#17
EDITORIAL
Jon Sussman
No abstract text is available yet for this article.
December 2016: Practical Neurology
https://www.readbyqxmd.com/read/28109346/robot-assisted-total-thymectomy-how-i%C3%A2-teach-it
#18
EDITORIAL
Lisa M Brown, Brian E Louie
No abstract text is available yet for this article.
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28104124/enhancing-survival-of-human-hepatocytes-by-neonatal-thymectomy-and-partial-hepatectomy-in-micro-miniature-pigs
#19
H C Hsu, S Enosawa, T Yamazaki, S Tohyama, J Fujita, K Fukuda, E Kobayashi
BACKGROUND: With the goal of in vivo cultivation of human hepatocytes that have not been sufficient in full differentiation in vitro, the advantage of neonatal thymectomy was verified on expansion of xenogeneic human hepatocyte in the micro-miniature pig (MMP). METHODS: The thymus was excised immediately after the birth of the MMPs via cesarean section. Newborns were fed by artificial feeding under specific pathogen-free conditions. The thymectomized and nonthymectomized littermates were transplanted with human hepatocytes via a portal vein with or without partial hepatectomy at the MMP adult stage...
January 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28100409/effect-of-thymectomy-for-thymic-atrophy-in-myasthenia-gravis-a-retrospective-study-on-93-patients
#20
Keiichi Nakahara, Shunya Nakane, Makoto Nakajima, Satoshi Yamashita, Takeshi Mori, Yukio Ando
To clarify the efficacy of thymectomy among myasthenia gravis (MG) patients with and without thymoma. We classified MG patients who underwent thymectomy into 3 groups, such as thymic atrophy group, thymic follicular hyperplasia (TFH) group and thymoma group. We compared the data of clinical features and postoperative prognosis at very short-term, short-term, and medium-term. The clinical course of MG patients with atrophic thymus after thymectomy was even better than those of TFH or thymoma, in this retrospective study...
January 12, 2017: Journal of Neuroimmunology
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