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https://www.readbyqxmd.com/read/28514723/genomic-profiling-of-pelvic-genital-type-leiomyosarcoma-in-a-woman-with-a-germline-chek2-c-1100delc-mutation-and-a-concomitant-diagnosis-of-metastatic-invasive-ductal-breast-carcinoma
#1
My Linh Thibodeau, Caralyn Reisle, Eric Zhao, Lee Ann Martin, Yazeed Alwelaie, Karen L Mungall, Carolyn Ch'ng, Ruth Thomas, Tony Ng, Stephen Yip, Howard Lim, Sophie Sun, Sean S Young, Aly Karsan, Yongjun Zhao, Andrew J Mungall, Richard A Moore, Daniel Renouf, Karen Gelmon, Yussanne P Ma, Malcolm Hayes, Janessa Laskin, Marco A Marra, Kasmintan A Schrader, Steven J M Jones
INTRODUCTION: We describe a woman with the known pathogenic germline variant CHEK2:c.1100delC and synchronous diagnoses of both pelvic genital type leiomyosarcoma and metastatic invasive ductal breast carcinoma. CHEK2 (checkpoint kinase 2) is a tumour suppressor gene encoding a serine/threonine-protein kinase (CHEK2) involved in double-strand DNA break repair and cell cycle arrest. The CHEK2:c.1100delC variant is a moderate penetrance allele resulting in an approximate 2-fold increase in breast cancer risk...
May 16, 2017: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/28512105/double-hit-lymphoma-presenting-as-haemophagocytic-lymphohistiocytosis
#2
Xavier Issac Rivera, Lee J McGhan, Jonathan H Schatz, Soham D Puvvada
No abstract text is available yet for this article.
May 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28502250/antiplasmodial-dihetarylthioethers-target-the-coenzyme-a-synthesis-pathway-in-plasmodium-falciparum-erythrocytic-stages
#3
Thomas Weidner, Leonardo Lucantoni, Abed Nasereddin, Lutz Preu, Peter G Jones, Ron Dzikowski, Vicky M Avery, Conrad Kunick
BACKGROUND: Malaria is a widespread infectious disease that threatens a large proportion of the population in tropical and subtropical areas. Given the emerging resistance against the current standard anti-malaria chemotherapeutics, the development of alternative drugs is urgently needed. New anti-malarials representing chemotypes unrelated to currently used drugs have an increased potential for displaying novel mechanisms of action and thus exhibit low risk of cross-resistance against established drugs...
May 15, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28496415/inflammatory-effects-of-menthol-vs-non-menthol-cigarette-smoke-extract-on-human-lung-epithelial-cells-a-double-hit-on-trpm8-by-reactive-oxygen-species-and-menthol
#4
An-Hsuan Lin, Meng-Han Liu, Hsin-Kuo B Ko, Diahn-Warng Perng, Tzong-Shyuan Lee, Yu Ru Kou
Clinical studies suggest that smokers with chronic obstructive pulmonary disease who use menthol cigarettes may display more severe lung inflammation than those who smoke non-menthol cigarette. However, the mechanisms for this difference remain unclear. Menthol is a ligand of transient receptor potential melastatin-8 (TRPM8), a Ca(2+)-permeant channel sensitive to reactive oxygen species (ROS). We previously reported that exposure of human bronchial epithelial cells (HBECs) to non-menthol cigarette smoke extract (Non-M-CSE) triggers a cascade of inflammatory signaling leading to IL-8 induction...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28486099/a-tiam-double-hit-to-oppose-yap-taz
#5
Luca Azzolin, Stefano Piccolo
In this issue of Cancer Cell, Diamantopoulou et al. uncover dual mechanisms of inhibiting YAP/TAZ by TIAM1 that oppose invasiveness of colorectal cancer cells: TIAM1 interacts with TAZ in the cytoplasm to promote TAZ degradation by the destruction complex, whereas it antagonizes binding of TAZ/YAP to TEAD in the nucleus.
May 8, 2017: Cancer Cell
https://www.readbyqxmd.com/read/28475457/outcomes-of-patients-with-double-hit-lymphoma-who-achieve-first-complete-remission
#6
Daniel J Landsburg, Marissa K Falkiewicz, Joseph Maly, Kristie A Blum, Christina Howlett, Tatyana Feldman, Anthony R Mato, Brian T Hill, Shaoying Li, L Jeffrey Medeiros, Pallawi Torka, Francisco Hernandez-Ilizaliturri, Nishitha M Reddy, Arun Singavi, Timothy S Fenske, Julio C Chavez, Jason B Kaplan, Amir Behdad, Adam M Petrich, Martin A Bast, Julie M Vose, Adam J Olszewski, Cristiana Costa, Frederick Lansigan, James N Gerson, Stefan K Barta, Oscar Calzada, Jonathon B Cohen, Jennifer K Lue, Jennifer E Amengual, Xavier Rivera, Daniel O Persky, David J Peace, Sunita Nathan, Ryan D Cassaday
Purpose Patients with double-hit lymphoma (DHL) rarely achieve long-term survival following disease relapse. Some patients with DHL undergo consolidative autologous stem-cell transplantation (autoSCT) to reduce the risk of relapse, although the benefit of this treatment strategy is unclear. Methods Patients with DHL who achieved first complete remission following completion of front-line therapy with either rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) or intensive front-line therapy, and deemed fit for autoSCT, were included...
May 5, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28474955/relative-modification-of-prompt-%C3%AF-2s-and-j-%C3%AF-yields-from-pp-to-pbpb-collisions-at-sqrt-s_-nn-5-02%C3%A2-%C3%A2-tev
#7
A M Sirunyan, A Tumasyan, W Adam, E Asilar, T Bergauer, J Brandstetter, E Brondolin, M Dragicevic, J Erö, M Flechl, M Friedl, R Frühwirth, V M Ghete, C Hartl, N Hörmann, J Hrubec, M Jeitler, A König, I Krätschmer, D Liko, T Matsushita, I Mikulec, D Rabady, N Rad, B Rahbaran, H Rohringer, J Schieck, J Strauss, W Waltenberger, C-E Wulz, V Chekhovsky, O Dvornikov, Y Dydyshka, I Emeliantchik, A Litomin, V Makarenko, V Mossolov, R Stefanovitch, J Suarez Gonzalez, V Zykunov, N Shumeiko, S Alderweireldt, E A De Wolf, X Janssen, J Lauwers, M Van De Klundert, H Van Haevermaet, P Van Mechelen, N Van Remortel, A Van Spilbeeck, S Abu Zeid, F Blekman, J D'Hondt, N Daci, I De Bruyn, K Deroover, S Lowette, S Moortgat, L Moreels, A Olbrechts, Q Python, K Skovpen, S Tavernier, W Van Doninck, P Van Mulders, I Van Parijs, H Brun, B Clerbaux, G De Lentdecker, H Delannoy, G Fasanella, L Favart, R Goldouzian, A Grebenyuk, G Karapostoli, T Lenzi, A Léonard, J Luetic, T Maerschalk, A Marinov, A Randle-Conde, T Seva, C Vander Velde, P Vanlaer, D Vannerom, R Yonamine, F Zenoni, F Zhang, A Cimmino, T Cornelis, D Dobur, A Fagot, G Garcia, M Gul, I Khvastunov, D Poyraz, S Salva, R Schöfbeck, M Tytgat, W Van Driessche, E Yazgan, N Zaganidis, H Bakhshiansohi, C Beluffi, O Bondu, S Brochet, G Bruno, A Caudron, S De Visscher, C Delaere, M Delcourt, B Francois, A Giammanco, A Jafari, P Jez, M Komm, G Krintiras, V Lemaitre, A Magitteri, A Mertens, M Musich, C Nuttens, K Piotrzkowski, L Quertenmont, M Selvaggi, M Vidal Marono, S Wertz, N Beliy, W L Aldá Júnior, F L Alves, G A Alves, L Brito, C Hensel, A Moraes, M E Pol, P Rebello Teles, E Belchior Batista Das Chagas, W Carvalho, J Chinellato, A Custódio, E M Da Costa, G G Da Silveira, D De Jesus Damiao, C De Oliveira Martins, S Fonseca De Souza, L M Huertas Guativa, H Malbouisson, D Matos Figueiredo, C Mora Herrera, L Mundim, H Nogima, W L Prado Da Silva, A Santoro, A Sznajder, E J Tonelli Manganote, A Vilela Pereira, S Ahuja, C A Bernardes, S Dogra, T R Fernandez Perez Tomei, E M Gregores, P G Mercadante, C S Moon, S F Novaes, Sandra S Padula, D Romero Abad, J C Ruiz Vargas, A Aleksandrov, R Hadjiiska, P Iaydjiev, M Rodozov, S Stoykova, G Sultanov, M Vutova, A Dimitrov, I Glushkov, L Litov, B Pavlov, P Petkov, W Fang, M Ahmad, J G Bian, G M Chen, H S Chen, M Chen, Y Chen, T Cheng, C H Jiang, D Leggat, Z Liu, F Romeo, S M Shaheen, A Spiezia, J Tao, C Wang, Z Wang, H Zhang, J Zhao, Y Ban, G Chen, Q Li, S Liu, Y Mao, S J Qian, D Wang, Z Xu, C Avila, A Cabrera, L F Chaparro Sierra, C Florez, J P Gomez, C F González Hernández, J D Ruiz Alvarez, J C Sanabria, N Godinovic, D Lelas, I Puljak, P M Ribeiro Cipriano, T Sculac, Z Antunovic, M Kovac, V Brigljevic, D Ferencek, K Kadija, B Mesic, S Micanovic, L Sudic, T Susa, A Attikis, G Mavromanolakis, J Mousa, C Nicolaou, F Ptochos, P A Razis, H Rykaczewski, D Tsiakkouri, M Finger, M Finger, E Carrera Jarrin, A Ellithi Kamel, M A Mahmoud, A Radi, M Kadastik, L Perrini, M Raidal, A Tiko, C Veelken, P Eerola, J Pekkanen, M Voutilainen, J Härkönen, T Järvinen, V Karimäki, R Kinnunen, T Lampén, K Lassila-Perini, S Lehti, T Lindén, P Luukka, J Tuominiemi, E Tuovinen, L Wendland, J Talvitie, T Tuuva, M Besancon, F Couderc, M Dejardin, D Denegri, B Fabbro, J L Faure, C Favaro, F Ferri, S Ganjour, S Ghosh, A Givernaud, P Gras, G Hamel de Monchenault, P Jarry, I Kucher, E Locci, M Machet, J Malcles, J Rander, A Rosowsky, M Titov, A Zghiche, A Abdulsalam, I Antropov, F Arleo, S Baffioni, F Beaudette, P Busson, L Cadamuro, E Chapon, C Charlot, O Davignon, R Granier de Cassagnac, M Jo, S Lisniak, J Martin Blanco, P Miné, M Nguyen, C Ochando, G Ortona, P Paganini, P Pigard, S Regnard, R Salerno, Y Sirois, A G Stahl Leiton, T Strebler, Y Yilmaz, A Zabi, J-L Agram, J Andrea, A Aubin, D Bloch, J-M Brom, M Buttignol, E C Chabert, N Chanon, C Collard, E Conte, X Coubez, J-C Fontaine, D Gelé, U Goerlach, A-C Le Bihan, P Van Hove, S Gadrat, S Beauceron, C Bernet, G Boudoul, C A Carrillo Montoya, R Chierici, D Contardo, B Courbon, P Depasse, H El Mamouni, J Fan, J Fay, S Gascon, M Gouzevitch, G Grenier, B Ille, F Lagarde, I B Laktineh, M Lethuillier, L Mirabito, A L Pequegnot, S Perries, A Popov, D Sabes, V Sordini, M Vander Donckt, P Verdier, S Viret, T Toriashvili, Z Tsamalaidze, C Autermann, S Beranek, L Feld, M K Kiesel, K Klein, M Lipinski, M Preuten, S Schael, C Schomakers, J Schulz, T Verlage, A Albert, M Brodski, E Dietz-Laursonn, D Duchardt, M Endres, M Erdmann, S Erdweg, T Esch, R Fischer, A Güth, M Hamer, T Hebbeker, C Heidemann, K Hoepfner, S Knutzen, M Merschmeyer, A Meyer, P Millet, S Mukherjee, M Olschewski, K Padeken, T Pook, M Radziej, H Reithler, M Rieger, F Scheuch, L Sonnenschein, D Teyssier, S Thüer, V Cherepanov, G Flügge, B Kargoll, T Kress, A Künsken, J Lingemann, T Müller, A Nehrkorn, A Nowack, C Pistone, O Pooth, A Stahl, M Aldaya Martin, T Arndt, C Asawatangtrakuldee, K Beernaert, O Behnke, U Behrens, A A Bin Anuar, K Borras, A Campbell, P Connor, C Contreras-Campana, F Costanza, C Diez Pardos, G Dolinska, G Eckerlin, D Eckstein, T Eichhorn, E Eren, E Gallo, J Garay Garcia, A Geiser, A Gizhko, J M Grados Luyando, A Grohsjean, P Gunnellini, A Harb, J Hauk, M Hempel, H Jung, A Kalogeropoulos, O Karacheban, M Kasemann, J Keaveney, C Kleinwort, I Korol, D Krücker, W Lange, A Lelek, J Leonard, K Lipka, A Lobanov, W Lohmann, R Mankel, I-A Melzer-Pellmann, A B Meyer, G Mittag, J Mnich, A Mussgiller, E Ntomari, D Pitzl, R Placakyte, A Raspereza, B Roland, M Ö Sahin, P Saxena, T Schoerner-Sadenius, C Seitz, S Spannagel, N Stefaniuk, G P Van Onsem, R Walsh, C Wissing, V Blobel, M Centis Vignali, A R Draeger, T Dreyer, E Garutti, D Gonzalez, J Haller, M Hoffmann, A Junkes, R Klanner, R Kogler, N Kovalchuk, T Lapsien, T Lenz, I Marchesini, D Marconi, M Meyer, M Niedziela, D Nowatschin, F Pantaleo, T Peiffer, A Perieanu, J Poehlsen, C Sander, C Scharf, P Schleper, A Schmidt, S Schumann, J Schwandt, H Stadie, G Steinbrück, F M Stober, M Stöver, H Tholen, D Troendle, E Usai, L Vanelderen, A Vanhoefer, B Vormwald, M Akbiyik, C Barth, S Baur, C Baus, J Berger, E Butz, R Caspart, T Chwalek, F Colombo, W De Boer, A Dierlamm, S Fink, B Freund, R Friese, M Giffels, A Gilbert, P Goldenzweig, D Haitz, F Hartmann, S M Heindl, U Husemann, I Katkov, S Kudella, H Mildner, M U Mozer, Th Müller, M Plagge, G Quast, K Rabbertz, S Röcker, F Roscher, M Schröder, I Shvetsov, G Sieber, H J Simonis, R Ulrich, S Wayand, M Weber, T Weiler, S Williamson, C Wöhrmann, R Wolf, G Anagnostou, G Daskalakis, T Geralis, V A Giakoumopoulou, A Kyriakis, D Loukas, I Topsis-Giotis, S Kesisoglou, A Panagiotou, N Saoulidou, E Tziaferi, I Evangelou, G Flouris, C Foudas, P Kokkas, N Loukas, N Manthos, I Papadopoulos, E Paradas, N Filipovic, G Bencze, C Hajdu, D Horvath, F Sikler, V Veszpremi, G Vesztergombi, A J Zsigmond, N Beni, S Czellar, J Karancsi, A Makovec, J Molnar, Z Szillasi, M Bartók, P Raics, Z L Trocsanyi, B Ujvari, S Bahinipati, S Choudhury, P Mal, K Mandal, A Nayak, D K Sahoo, N Sahoo, S K Swain, S Bansal, S B Beri, V Bhatnagar, R Chawla, U Bhawandeep, A K Kalsi, A Kaur, M Kaur, R Kumar, P Kumari, A Mehta, M Mittal, J B Singh, G Walia, Ashok Kumar, A Bhardwaj, B C Choudhary, R B Garg, S Keshri, S Malhotra, M Naimuddin, N Nishu, K Ranjan, R Sharma, V Sharma, R Bhattacharya, S Bhattacharya, K Chatterjee, S Dey, S Dutt, S Dutta, S Ghosh, N Majumdar, A Modak, K Mondal, S Mukhopadhyay, S Nandan, A Purohit, A Roy, D Roy, S Roy Chowdhury, S Sarkar, M Sharan, S Thakur, P K Behera, R Chudasama, D Dutta, V Jha, V Kumar, A K Mohanty, P K Netrakanti, L M Pant, P Shukla, A Topkar, T Aziz, S Dugad, G Kole, B Mahakud, S Mitra, G B Mohanty, B Parida, N Sur, B Sutar, S Banerjee, S Bhowmik, R K Dewanjee, S Ganguly, M Guchait, Sa Jain, S Kumar, M Maity, G Majumder, K Mazumdar, T Sarkar, N Wickramage, S Chauhan, S Dube, V Hegde, A Kapoor, K Kothekar, S Pandey, A Rane, S Sharma, S Chenarani, E Eskandari Tadavani, S M Etesami, A Fahim, M Khakzad, M Mohammadi Najafabadi, M Naseri, S Paktinat Mehdiabadi, F Rezaei Hosseinabadi, B Safarzadeh, M Zeinali, M Felcini, M Grunewald, M Abbrescia, C Calabria, C Caputo, A Colaleo, D Creanza, L Cristella, N De Filippis, M De Palma, L Fiore, G Iaselli, G Maggi, M Maggi, G Miniello, S My, S Nuzzo, A Pompili, G Pugliese, R Radogna, A Ranieri, G Selvaggi, A Sharma, L Silvestris, R Venditti, P Verwilligen, G Abbiendi, C Battilana, D Bonacorsi, S Braibant-Giacomelli, L Brigliadori, R Campanini, P Capiluppi, A Castro, F R Cavallo, S S Chhibra, G Codispoti, M Cuffiani, G M Dallavalle, F Fabbri, A Fanfani, D Fasanella, P Giacomelli, C Grandi, L Guiducci, S Marcellini, G Masetti, A Montanari, F L Navarria, A Perrotta, A M Rossi, T Rovelli, G P Siroli, N Tosi, S Albergo, S Costa, A Di Mattia, F Giordano, R Potenza, A Tricomi, C Tuve, G Barbagli, V Ciulli, C Civinini, R D'Alessandro, E Focardi, P Lenzi, M Meschini, S Paoletti, G Sguazzoni, L Viliani, L Benussi, S Bianco, F Fabbri, D Piccolo, F Primavera, V Calvelli, F Ferro, M Lo Vetere, M R Monge, E Robutti, S Tosi, L Brianza, F Brivio, M E Dinardo, S Fiorendi, S Gennai, A Ghezzi, P Govoni, M Malberti, S Malvezzi, R A Manzoni, D Menasce, L Moroni, M Paganoni, D Pedrini, S Pigazzini, S Ragazzi, T Tabarelli de Fatis, S Buontempo, N Cavallo, G De Nardo, S Di Guida, M Esposito, F Fabozzi, F Fienga, A O M Iorio, G Lanza, L Lista, S Meola, P Paolucci, C Sciacca, F Thyssen, P Azzi, N Bacchetta, L Benato, D Bisello, A Boletti, R Carlin, A Carvalho Antunes De Oliveira, P Checchia, M Dall'Osso, P De Castro Manzano, T Dorigo, U Dosselli, F Gasparini, U Gasparini, A Gozzelino, S Lacaprara, M Margoni, A T Meneguzzo, J Pazzini, N Pozzobon, P Ronchese, F Simonetto, E Torassa, M Zanetti, P Zotto, G Zumerle, A Braghieri, A Magnani, P Montagna, S P Ratti, V Re, C Riccardi, P Salvini, I Vai, P Vitulo, L Alunni Solestizi, G M Bilei, D Ciangottini, L Fanò, P Lariccia, R Leonardi, G Mantovani, M Menichelli, A Saha, A Santocchia, K Androsov, P Azzurri, G Bagliesi, J Bernardini, T Boccali, R Castaldi, M A Ciocci, R Dell'Orso, S Donato, G Fedi, A Giassi, M T Grippo, F Ligabue, T Lomtadze, L Martini, A Messineo, F Palla, A Rizzi, A Savoy-Navarro, P Spagnolo, R Tenchini, G Tonelli, A Venturi, P G Verdini, L Barone, F Cavallari, M Cipriani, D Del Re, M Diemoz, S Gelli, E Longo, F Margaroli, B Marzocchi, P Meridiani, G Organtini, R Paramatti, F Preiato, S Rahatlou, C Rovelli, F Santanastasio, N Amapane, R Arcidiacono, S Argiro, M Arneodo, N Bartosik, R Bellan, C Biino, N Cartiglia, F Cenna, M Costa, R Covarelli, A Degano, N Demaria, L Finco, B Kiani, C Mariotti, S Maselli, E Migliore, V Monaco, E Monteil, M Monteno, M M Obertino, L Pacher, N Pastrone, M Pelliccioni, G L Pinna Angioni, F Ravera, A Romero, M Ruspa, R Sacchi, K Shchelina, V Sola, A Solano, A Staiano, P Traczyk, S Belforte, M Casarsa, F Cossutti, G Della Ricca, A Zanetti, D H Kim, G N Kim, M S Kim, S Lee, S W Lee, Y D Oh, S Sekmen, D C Son, Y C Yang, A Lee, H Kim, J A Brochero Cifuentes, T J Kim, S Cho, S Choi, Y Go, D Gyun, S Ha, B Hong, Y Jo, Y Kim, B Lee, K Lee, K S Lee, S Lee, J Lim, S K Park, Y Roh, J Almond, J Kim, H Lee, S B Oh, B C Radburn-Smith, S H Seo, U K Yang, H D Yoo, G B Yu, M Choi, H Kim, J H Kim, J S H Lee, I C Park, G Ryu, M S Ryu, Y Choi, J Goh, C Hwang, J Lee, I Yu, V Dudenas, A Juodagalvis, J Vaitkus, I Ahmed, Z A Ibrahim, J R Komaragiri, M A B Md Ali, F Mohamad Idris, W A T Wan Abdullah, M N Yusli, Z Zolkapli, H Castilla-Valdez, E De La Cruz-Burelo, I Heredia-De La Cruz, A Hernandez-Almada, R Lopez-Fernandez, R Magaña Villalba, J Mejia Guisao, A Sanchez-Hernandez, S Carrillo Moreno, C Oropeza Barrera, F Vazquez Valencia, S Carpinteyro, I Pedraza, H A Salazar Ibarguen, C Uribe Estrada, A Morelos Pineda, D Krofcheck, P H Butler, A Ahmad, M Ahmad, Q Hassan, H R Hoorani, W A Khan, A Saddique, M A Shah, M Shoaib, M Waqas, H Bialkowska, M Bluj, B Boimska, T Frueboes, M Górski, M Kazana, K Nawrocki, K Romanowska-Rybinska, M Szleper, P Zalewski, K Bunkowski, A Byszuk, K Doroba, A Kalinowski, M Konecki, J Krolikowski, M Misiura, M Olszewski, M Walczak, P Bargassa, C Beirão Da Cruz E Silva, B Calpas, A Di Francesco, P Faccioli, P G Ferreira Parracho, M Gallinaro, J Hollar, N Leonardo, L Lloret Iglesias, M V Nemallapudi, J Rodrigues Antunes, J Seixas, O Toldaiev, D Vadruccio, J Varela, P Vischia, S Afanasiev, P Bunin, M Gavrilenko, I Golutvin, I Gorbunov, A Kamenev, V Karjavin, A Lanev, A Malakhov, V Matveev, V Palichik, V Perelygin, S Shmatov, S Shulha, N Skatchkov, V Smirnov, N Voytishin, A Zarubin, L Chtchipounov, V Golovtsov, Y Ivanov, V Kim, E Kuznetsova, V Murzin, V Oreshkin, V Sulimov, A Vorobyev, Yu Andreev, A Dermenev, S Gninenko, N Golubev, A Karneyeu, M Kirsanov, N Krasnikov, A Pashenkov, D Tlisov, A Toropin, V Epshteyn, V Gavrilov, N Lychkovskaya, V Popov, I Pozdnyakov, G Safronov, A Spiridonov, M Toms, E Vlasov, A Zhokin, A Bylinkin, R Chistov, O Markin, S Polikarpov, V Andreev, M Azarkin, I Dremin, M Kirakosyan, A Leonidov, A Terkulov, A Baskakov, A Belyaev, E Boos, A Ershov, A Gribushin, A Kaminskiy, O Kodolova, V Korotkikh, I Lokhtin, I Miagkov, S Obraztsov, S Petrushanko, V Savrin, A Snigirev, I Vardanyan, V Blinov, Y Skovpen, D Shtol, I Azhgirey, I Bayshev, S Bitioukov, D Elumakhov, V Kachanov, A Kalinin, D Konstantinov, V Krychkine, V Petrov, R Ryutin, A Sobol, S Troshin, N Tyurin, A Uzunian, A Volkov, P Adzic, P Cirkovic, D Devetak, M Dordevic, J Milosevic, V Rekovic, J Alcaraz Maestre, M Barrio Luna, E Calvo, M Cerrada, M Chamizo Llatas, N Colino, B De La Cruz, A Delgado Peris, A Escalante Del Valle, C Fernandez Bedoya, J P Fernández Ramos, J Flix, M C Fouz, P Garcia-Abia, O Gonzalez Lopez, S Goy Lopez, J M Hernandez, M I Josa, E Navarro De Martino, A Pérez-Calero Yzquierdo, J Puerta Pelayo, A Quintario Olmeda, I Redondo, L Romero, M S Soares, J F de Trocóniz, M Missiroli, D Moran, J Cuevas, J Fernandez Menendez, I Gonzalez Caballero, J R González Fernández, E Palencia Cortezon, S Sanchez Cruz, I Suárez Andrés, J M Vizan Garcia, I J Cabrillo, A Calderon, J R Castiñeiras De Saa, E Curras, M Fernandez, J Garcia-Ferrero, G Gomez, A Lopez Virto, J Marco, C Martinez Rivero, F Matorras, J Piedra Gomez, T Rodrigo, A Ruiz-Jimeno, L Scodellaro, N Trevisani, I Vila, R Vilar Cortabitarte, D Abbaneo, E Auffray, G Auzinger, M Bachtis, P Baillon, A H Ball, D Barney, P Bloch, A Bocci, A Bonato, C Botta, T Camporesi, R Castello, M Cepeda, G Cerminara, D d'Enterria, A Dabrowski, V Daponte, A David, M De Gruttola, A De Roeck, E Di Marco, M Dobson, B Dorney, T du Pree, D Duggan, M Dünser, N Dupont, A Elliott-Peisert, P Everaerts, S Fartoukh, G Franzoni, J Fulcher, W Funk, D Gigi, K Gill, M Girone, F Glege, D Gulhan, S Gundacker, M Guthoff, J Hammer, P Harris, J Hegeman, V Innocente, P Janot, J Kieseler, H Kirschenmann, V Knünz, A Kornmayer, M J Kortelainen, K Kousouris, M Krammer, C Lange, P Lecoq, C Lourenço, M T Lucchini, L Malgeri, M Mannelli, A Martelli, F Meijers, J A Merlin, S Mersi, E Meschi, P Milenovic, F Moortgat, S Morovic, M Mulders, H Neugebauer, S Orfanelli, L Orsini, L Pape, E Perez, M Peruzzi, A Petrilli, G Petrucciani, A Pfeiffer, M Pierini, A Racz, T Reis, G Rolandi, M Rovere, M Ruan, H Sakulin, J B Sauvan, C Schäfer, C Schwick, M Seidel, A Sharma, P Silva, P Sphicas, J Steggemann, M Stoye, Y Takahashi, M Tosi, D Treille, A Triossi, A Tsirou, V Veckalns, G I Veres, M Verweij, N Wardle, H K Wöhri, A Zagozdzinska, W D Zeuner, W Bertl, K Deiters, W Erdmann, R Horisberger, Q Ingram, H C Kaestli, D Kotlinski, U Langenegger, T Rohe, F Bachmair, L Bäni, L Bianchini, B Casal, G Dissertori, M Dittmar, M Donegà, C Grab, C Heidegger, D Hits, J Hoss, G Kasieczka, P Lecomte, W Lustermann, B Mangano, M Marionneau, P Martinez Ruiz Del Arbol, M Masciovecchio, M T Meinhard, D Meister, F Micheli, P Musella, F Nessi-Tedaldi, F Pandolfi, J Pata, F Pauss, G Perrin, L Perrozzi, M Quittnat, M Rossini, M Schönenberger, A Starodumov, V R Tavolaro, K Theofilatos, R Wallny, T K Aarrestad, C Amsler, L Caminada, M F Canelli, A De Cosa, C Galloni, A Hinzmann, T Hreus, B Kilminster, J Ngadiuba, D Pinna, G Rauco, P Robmann, D Salerno, Y Yang, A Zucchetta, V Candelise, T H Doan, Sh Jain, R Khurana, M Konyushikhin, C M Kuo, W Lin, Y J Lu, A Pozdnyakov, S S Yu, Arun Kumar, P Chang, Y H Chang, Y W Chang, Y Chao, K F Chen, P H Chen, C Dietz, F Fiori, W-S Hou, Y Hsiung, Y F Liu, R-S Lu, M Miñano Moya, E Paganis, A Psallidas, J F Tsai, Y M Tzeng, B Asavapibhop, G Singh, N Srimanobhas, N Suwonjandee, A Adiguzel, S Cerci, S Damarseckin, Z S Demiroglu, C Dozen, I Dumanoglu, S Girgis, G Gokbulut, Y Guler, I Hos, E E Kangal, O Kara, A Kayis Topaksu, U Kiminsu, M Oglakci, G Onengut, K Ozdemir, D Sunar Cerci, B Tali, S Turkcapar, I S Zorbakir, C Zorbilmez, B Bilin, S Bilmis, B Isildak, G Karapinar, M Yalvac, M Zeyrek, E Gülmez, M Kaya, O Kaya, E A Yetkin, T Yetkin, A Cakir, K Cankocak, S Sen, B Grynyov, L Levchuk, P Sorokin, R Aggleton, F Ball, L Beck, J J Brooke, D Burns, E Clement, D Cussans, H Flacher, J Goldstein, M Grimes, G P Heath, H F Heath, J Jacob, L Kreczko, C Lucas, D M Newbold, S Paramesvaran, A Poll, T Sakuma, S Seif El Nasr-Storey, D Smith, V J Smith, A Belyaev, C Brew, R M Brown, L Calligaris, D Cieri, D J A Cockerill, J A Coughlan, K Harder, S Harper, E Olaiya, D Petyt, C H Shepherd-Themistocleous, A Thea, I R Tomalin, T Williams, M Baber, R Bainbridge, O Buchmuller, A Bundock, D Burton, S Casasso, M Citron, D Colling, L Corpe, P Dauncey, G Davies, A De Wit, M Della Negra, R Di Maria, P Dunne, A Elwood, D Futyan, Y Haddad, G Hall, G Iles, T James, R Lane, C Laner, R Lucas, L Lyons, A-M Magnan, S Malik, L Mastrolorenzo, J Nash, A Nikitenko, J Pela, B Penning, M Pesaresi, D M Raymond, A Richards, A Rose, C Seez, S Summers, A Tapper, K Uchida, M Vazquez Acosta, T Virdee, J Wright, S C Zenz, J E Cole, P R Hobson, A Khan, P Kyberd, D Leslie, I D Reid, P Symonds, L Teodorescu, M Turner, A Borzou, K Call, J Dittmann, K Hatakeyama, H Liu, N Pastika, S I Cooper, C Henderson, P Rumerio, C West, D Arcaro, A Avetisyan, T Bose, D Gastler, D Rankin, C Richardson, J Rohlf, L Sulak, D Zou, G Benelli, E Berry, D Cutts, A Garabedian, J Hakala, U Heintz, J M Hogan, O Jesus, K H M Kwok, E Laird, G Landsberg, Z Mao, M Narain, S Piperov, S Sagir, E Spencer, R Syarif, R Breedon, G Breto, D Burns, M Calderon De La Barca Sanchez, S Chauhan, M Chertok, J Conway, R Conway, P T Cox, R Erbacher, C Flores, G Funk, M Gardner, W Ko, R Lander, C Mclean, M Mulhearn, D Pellett, J Pilot, S Shalhout, J Smith, M Squires, D Stolp, M Tripathi, C Bravo, R Cousins, A Dasgupta, A Florent, J Hauser, M Ignatenko, N Mccoll, D Saltzberg, C Schnaible, E Takasugi, V Valuev, M Weber, E Bouvier, K Burt, R Clare, J Ellison, J W Gary, S M A Ghiasi Shirazi, G Hanson, J Heilman, P Jandir, E Kennedy, F Lacroix, O R Long, M Olmedo Negrete, M I Paneva, A Shrinivas, W Si, H Wei, S Wimpenny, B R Yates, J G Branson, G B Cerati, S Cittolin, M Derdzinski, R Gerosa, A Holzner, D Klein, V Krutelyov, J Letts, I Macneill, D Olivito, S Padhi, M Pieri, M Sani, V Sharma, S Simon, M Tadel, A Vartak, S Wasserbaech, C Welke, J Wood, F Würthwein, A Yagil, G Zevi Della Porta, N Amin, R Bhandari, J Bradmiller-Feld, C Campagnari, A Dishaw, V Dutta, M Franco Sevilla, C George, F Golf, L Gouskos, J Gran, R Heller, J Incandela, S D Mullin, A Ovcharova, H Qu, J Richman, D Stuart, I Suarez, J Yoo, D Anderson, J Bendavid, A Bornheim, J Bunn, Y Chen, J Duarte, J M Lawhorn, A Mott, H B Newman, C Pena, M Spiropulu, J R Vlimant, S Xie, R Y Zhu, M B Andrews, T Ferguson, M Paulini, J Russ, M Sun, H Vogel, I Vorobiev, M Weinberg, J P Cumalat, W T Ford, F Jensen, A Johnson, M Krohn, T Mulholland, K Stenson, S R Wagner, J Alexander, J Chaves, J Chu, S Dittmer, K Mcdermott, N Mirman, G Nicolas Kaufman, J R Patterson, A Rinkevicius, A Ryd, L Skinnari, L Soffi, S M Tan, Z Tao, J Thom, J Tucker, P Wittich, M Zientek, D Winn, S Abdullin, M Albrow, G Apollinari, A Apresyan, S Banerjee, L A T Bauerdick, A Beretvas, J Berryhill, P C Bhat, G Bolla, K Burkett, J N Butler, H W K Cheung, F Chlebana, S Cihangir, M Cremonesi, V D Elvira, I Fisk, J Freeman, E Gottschalk, L Gray, D Green, S Grünendahl, O Gutsche, D Hare, R M Harris, S Hasegawa, J Hirschauer, Z Hu, B Jayatilaka, S Jindariani, M Johnson, U Joshi, B Klima, B Kreis, S Lammel, J Linacre, D Lincoln, R Lipton, M Liu, T Liu, R Lopes De Sá, J Lykken, K Maeshima, N Magini, J M Marraffino, S Maruyama, D Mason, P McBride, P Merkel, S Mrenna, S Nahn, V O'Dell, K Pedro, O Prokofyev, G Rakness, L Ristori, E Sexton-Kennedy, A Soha, W J Spalding, L Spiegel, S Stoynev, J Strait, N Strobbe, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, C Vernieri, M Verzocchi, R Vidal, M Wang, H A Weber, A Whitbeck, Y Wu, D Acosta, P Avery, P Bortignon, D Bourilkov, A Brinkerhoff, A Carnes, M Carver, D Curry, S Das, R D Field, I K Furic, J Konigsberg, A Korytov, J F Low, P Ma, K Matchev, H Mei, G Mitselmakher, D Rank, L Shchutska, D Sperka, L Thomas, J Wang, S Wang, J Yelton, S Linn, P Markowitz, G Martinez, J L Rodriguez, A Ackert, J R Adams, T Adams, A Askew, S Bein, B Diamond, S Hagopian, V Hagopian, K F Johnson, H Prosper, A Santra, R Yohay, M M Baarmand, V Bhopatkar, S Colafranceschi, M Hohlmann, D Noonan, T Roy, F Yumiceva, M R Adams, L Apanasevich, D Berry, R R Betts, I Bucinskaite, R Cavanaugh, O Evdokimov, L Gauthier, C E Gerber, D J Hofman, K Jung, P Kurt, C O'Brien, I D Sandoval Gonzalez, P Turner, N Varelas, H Wang, Z Wu, M Zakaria, J Zhang, B Bilki, W Clarida, K Dilsiz, S Durgut, R P Gandrajula, M Haytmyradov, V Khristenko, J-P Merlo, H Mermerkaya, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, A Penzo, C Snyder, E Tiras, J Wetzel, K Yi, I Anderson, B Blumenfeld, A Cocoros, N Eminizer, D Fehling, L Feng, A V Gritsan, P Maksimovic, C Martin, M Osherson, J Roskes, U Sarica, M Swartz, M Xiao, Y Xin, C You, A Al-Bataineh, P Baringer, A Bean, S Boren, J Bowen, C Bruner, J Castle, L Forthomme, R P Kenny, S Khalil, A Kropivnitskaya, D Majumder, W Mcbrayer, M Murray, S Sanders, R Stringer, J D Tapia Takaki, Q Wang, A Ivanov, K Kaadze, Y Maravin, A Mohammadi, L K Saini, N Skhirtladze, S Toda, F Rebassoo, D Wright, C Anelli, A Baden, O Baron, A Belloni, B Calvert, S C Eno, C Ferraioli, J A Gomez, N J Hadley, S Jabeen, R G Kellogg, T Kolberg, J Kunkle, Y Lu, A C Mignerey, F Ricci-Tam, Y H Shin, A Skuja, M B Tonjes, S C Tonwar, D Abercrombie, B Allen, A Apyan, V Azzolini, R Barbieri, A Baty, R Bi, K Bierwagen, S Brandt, W Busza, I A Cali, M D'Alfonso, Z Demiragli, L Di Matteo, G Gomez Ceballos, M Goncharov, D Hsu, Y Iiyama, G M Innocenti, M Klute, D Kovalskyi, K Krajczar, Y S Lai, Y-J Lee, A Levin, P D Luckey, B Maier, A C Marini, C Mcginn, C Mironov, S Narayanan, X Niu, C Paus, C Roland, G Roland, J Salfeld-Nebgen, G S F Stephans, K Tatar, M Varma, D Velicanu, J Veverka, J Wang, T W Wang, B Wyslouch, M Yang, V Zhukova, A C Benvenuti, R M Chatterjee, A Evans, A Finkel, A Gude, P Hansen, S Kalafut, S C Kao, Y Kubota, Z Lesko, J Mans, S Nourbakhsh, N Ruckstuhl, R Rusack, N Tambe, J Turkewitz, J G Acosta, S Oliveros, E Avdeeva, R Bartek, K Bloom, D R Claes, A Dominguez, C Fangmeier, R Gonzalez Suarez, R Kamalieddin, I Kravchenko, A Malta Rodrigues, F Meier, J Monroy, J E Siado, G R Snow, B Stieger, M Alyari, J Dolen, J George, A Godshalk, C Harrington, I Iashvili, J Kaisen, A Kharchilava, A Kumar, A Parker, S Rappoccio, B Roozbahani, G Alverson, E Barberis, A Hortiangtham, A Massironi, D M Morse, D Nash, T Orimoto, R Teixeira De Lima, D Trocino, R-J Wang, D Wood, S Bhattacharya, O Charaf, K A Hahn, A Kubik, A Kumar, N Mucia, N Odell, B Pollack, M H Schmitt, K Sung, M Trovato, M Velasco, N Dev, M Hildreth, K Hurtado Anampa, C Jessop, D J Karmgard, N Kellams, K Lannon, N Marinelli, F Meng, C Mueller, Y Musienko, M Planer, A Reinsvold, R Ruchti, G Smith, S Taroni, M Wayne, M Wolf, A Woodard, J Alimena, L Antonelli, B Bylsma, L S Durkin, S Flowers, B Francis, A Hart, C Hill, R Hughes, W Ji, B Liu, W Luo, D Puigh, B L Winer, H W Wulsin, S Cooperstein, O Driga, P Elmer, J Hardenbrook, P Hebda, D Lange, J Luo, D Marlow, T Medvedeva, K Mei, M Mooney, J Olsen, C Palmer, P Piroué, D Stickland, A Svyatkovskiy, C Tully, A Zuranski, S Malik, A Barker, V E Barnes, S Folgueras, L Gutay, M K Jha, M Jones, A W Jung, A Khatiwada, D H Miller, N Neumeister, J F Schulte, X Shi, J Sun, F Wang, W Xie, N Parashar, J Stupak, A Adair, B Akgun, Z Chen, K M Ecklund, F J M Geurts, M Guilbaud, W Li, B Michlin, M Northup, B P Padley, R Redjimi, J Roberts, J Rorie, Z Tu, J Zabel, B Betchart, A Bodek, P de Barbaro, R Demina, Y T Duh, T Ferbel, M Galanti, A Garcia-Bellido, J Han, O Hindrichs, A Khukhunaishvili, K H Lo, P Tan, M Verzetti, A Agapitos, J P Chou, E Contreras-Campana, Y Gershtein, T A Gómez Espinosa, E Halkiadakis, M Heindl, D Hidas, E Hughes, S Kaplan, R Kunnawalkam Elayavalli, S Kyriacou, A Lath, K Nash, H Saka, S Salur, S Schnetzer, D Sheffield, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, A G Delannoy, M Foerster, J Heideman, G Riley, K Rose, S Spanier, K Thapa, O Bouhali, A Celik, M Dalchenko, M De Mattia, A Delgado, S Dildick, R Eusebi, J Gilmore, T Huang, E Juska, T Kamon, R Mueller, Y Pakhotin, R Patel, A Perloff, L Perniè, D Rathjens, A Rose, A Safonov, A Tatarinov, K A Ulmer, N Akchurin, C Cowden, J Damgov, F De Guio, C Dragoiu, P R Dudero, J Faulkner, E Gurpinar, S Kunori, K Lamichhane, S W Lee, T Libeiro, T Peltola, S Undleeb, I Volobouev, Z Wang, S Greene, A Gurrola, R Janjam, W Johns, C Maguire, A Melo, H Ni, P Sheldon, S Tuo, J Velkovska, Q Xu, M W Arenton, P Barria, B Cox, J Goodell, R Hirosky, A Ledovskoy, H Li, C Neu, T Sinthuprasith, X Sun, Y Wang, E Wolfe, F Xia, C Clarke, R Harr, P E Karchin, J Sturdy, D A Belknap, J Buchanan, C Caillol, S Dasu, L Dodd, S Duric, B Gomber, M Grothe, M Herndon, A Hervé, P Klabbers, A Lanaro, A Levine, K Long, R Loveless, I Ojalvo, T Perry, G A Pierro, G Polese, T Ruggles, A Savin, N Smith, W H Smith, D Taylor, N Woods
The relative modification of the prompt ψ(2S) and J/ψ yields from pp to PbPb collisions, at the center-of-mass energy of 5.02 TeV per nucleon pair, is presented. The analysis is based on pp and PbPb data samples collected by the CMS experiment at the LHC in 2015, corresponding to integrated luminosities of 28.0  pb^{-1} and 464  μb^{-1}, respectively. The double ratio of measured yields of prompt charmonia reconstructed through their decays into muon pairs, (N_{ψ(2S)}/N_{J/ψ})_{PbPb}/(N_{ψ(2S)}/N_{J/ψ})_{pp}, is determined as a function of PbPb collision centrality and charmonium transverse momentum p_{T}, in two kinematic intervals: |y|<1...
April 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28466069/early-social-isolation-stress-and-perinatal-nmda-receptor-antagonist-treatment-induce-changes-in-the-structure-and-neurochemistry-of-inhibitory-neurons-of-the-adult-amygdala-and-prefrontal-cortex
#8
Esther Castillo-Gómez, Marta Pérez-Rando, María Bellés, Javier Gilabert-Juan, José Vicente Llorens, Héctor Carceller, Clara Bueno-Fernández, Clara García-Mompó, Beatriz Ripoll-Martínez, Yasmina Curto, Noelia Sebastiá-Ortega, María Dolores Moltó, Julio Sanjuan, Juan Nacher
The exposure to aversive experiences during early life influences brain development and leads to altered behavior. Moreover, the combination of these experiences with subtle alterations in neurodevelopment may contribute to the emergence of psychiatric disorders, such as schizophrenia. Recent hypotheses suggest that imbalances between excitatory and inhibitory (E/I) neurotransmission, especially in the prefrontal cortex and the amygdala, may underlie their etiopathology. In order to understand better the neurobiological bases of these alterations, we studied the impact of altered neurodevelopment and chronic early-life stress on these two brain regions...
March 2017: ENeuro
https://www.readbyqxmd.com/read/28460620/cx-4945-a-selective-inhibitor-of-casein-kinase-2-synergizes-with-b-cell-receptor-signaling-inhibitors-in-inducing-diffuse-large-b-cell-lymphoma-cell-death
#9
Elisa Mandato, Sara Canovas Nunes, Fortunato Zaffino, Alessandro Casellato, Paolo Macaccaro, Laura Quotti Tubi, Andrea Visentin, Livio Trentin, Gianpietro Semenzato, Francesco Piazza
BACKGROUND: Approximately one third of Diffuse Large B cell Lymphomas (DLBCL) are refractory or relapse. Novel therapeutic approaches under scrutiny include inhibitors of B-cell receptor (BCR) signaling. Protein kinase CK2 propels survival, proliferation and stress response in solid and hematologic malignancies and promotes a "non-oncogene addiction" phenotype. Whether this kinase regulates BCR signaling thus being a suitable pharmacological target in DLBCL is unknown. OBJECTIVE: To establish if CK2 controls DLBCL cell survival and the BCR signaling; to check if the combination of CK2 inhibitor CX-4945 and BCR blockers Ibrutinib and Fostamatinib is more effectively cytotoxic for DLBCL cells than the single agents; to survey the changes in signaling molecules downstream BCR upon CK2 inhibition...
April 26, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28446673/pacmanvirus-a-new-giant-icosahedral-virus-at-the-crossroads-between-asfarviridae-and-faustoviruses
#10
Julien Andreani, Jacques Yaacoub Bou Khalil, Madhumati Sevvana, Samia Benamar, Fabrizio Di Pinto, Idir Bitam, Philippe Colson, Thomas Klose, Michael G Rossmann, Didier Raoult, Bernard La Scola
African swine fever virus, a double stranded DNA virus infecting pigs, is the only known member of the Asfarviridae family. Nevertheless, during our isolation and sequencing of the complete genome of Faustovirus followed by the description of Kaumoebavirus, carried out over the past two years, we observed the emergence of previously unknown related viruses within this group of viruses. Here, we describe the isolation of Pacmanvirus, a fourth member in this group, capable of infecting Acanthamoeba castellanii...
April 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28439537/the-nearly-universal-link-between-the-age-of-past-knowledge-and-tomorrow-s-breakthroughs-in-science-and-technology-the-hotspot
#11
Satyam Mukherjee, Daniel M Romero, Ben Jones, Brian Uzzi
Scientists and inventors can draw on an ever-expanding literature for the building blocks of tomorrow's ideas, yet little is known about how combinations of past work are related to future discoveries. Our analysis parameterizes the age distribution of a work's references and revealed three links between the age of prior knowledge and hit papers and patents. First, works that cite literature with a low mean age and high age variance are in a citation "hotspot"; these works double their likelihood of being in the top 5% or better of citations...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28426938/high-throughput-screening-to-identify-inhibitors-of-dead-box-helicase-ddx41
#12
Mariko Yoneyama-Hirozane, Mitsuyo Kondo, Shin-Ichi Matsumoto, Akiko Morikawa-Oki, Daisuke Morishita, Atsushi Nakanishi, Tomohiro Kawamoto, Masaharu Nakayama
The human DEAD (Asp-Glu-Ala-Asp) box protein DDX41, a member of the DEXDc helicase family, has nucleic acid-dependent ATPase and RNA and DNA translocase and unwinding activities. DDX41 is affected by somatic mutations in sporadic cases of myeloid neoplasms as well as in a biallelic fashion in 50% of patients with germline DDX41 mutations. The R525H mutation in DDX41 is thought to play important roles in the development of hereditary myelodysplastic syndrome and acute myelocytic leukemia. In this study, human DDX41 and its R525H mutant (R525H) were expressed in Escherichia coli and purified...
April 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28424078/interleukin-6-displays-lung-anti-inflammatory-properties-and-exerts-protective-hemodynamic-effects-in-a-double-hit-murine-acute-lung-injury
#13
Guillaume Voiriot, Keyvan Razazi, Valérie Amsellem, Jeanne Tran Van Nhieu, Shariq Abid, Serge Adnot, Armand Mekontso Dessap, Bernard Maitre
BACKGROUND: Interleukin 6 (IL-6) is a predictive factor of poor prognosis in patients with acute respiratory distress syndrome (ARDS). However, its acute pulmonary hemodynamic effects and role in lung injury have not been investigated in a clinically relevant murine model of ARDS. METHODS: We used adult C57Bl6 wild-type (WT) and IL-6 knock-out (IL-6KO) mice. The animals received intravenous recombinant human IL-6 (rHuIL-6) or vehicle followed by intratracheal lipopolysaccharide (LPS) or saline before undergoing low tidal volume mechanical ventilation (MV) for 5 h...
April 19, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28416758/synergistic-interactions-between-plk1-and-hdac-inhibitors-in-non-hodgkin-s-lymphoma-cells-occur-in-vitro-and-in-vivo-and-proceed-through-multiple-mechanisms
#14
Tri Nguyen, Rebecca Parker, Elisa Hawkins, Beata Holkova, Victor Yazbeck, Akhil Kolluri, Maciej Kmieciak, Mohamed Rahmani, Steven Grant
Interactions between the polo-like kinase 1 (PLK1) inhibitor volasertib and the histone deacetylase inhibitor (HDACI) belinostat were examined in diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) cells in vitro and in vivo. Exposure of DLBCL cells to very low concentrations of volasertib in combination with belinostat synergistically increased cell death (apoptosis). Similar interactions occurred in GC-, ABC-, double-hit DLBCL cells, MCL cells, bortezomib-resistant cells and primary lymphoma cells...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28400483/somatic-and-inherited-mutations-in-primary-aldosteronism
#15
Fabio Luiz Fernandes-Rosa, Sheerazed Boulkroun, Maria-Christina Zennaro
Primary aldosteronism (PA), the most common form of secondary hypertension, is caused in the majority of cases by unilateral aldosterone producing adenoma (APA) or bilateral adrenal hyperplasia. In the last years, recurrent somatic mutations in KCNJ5, CACNA1D, ATP1A1, and ATP2B3 were proved to be associated with APA development, explaining more than 50% of sporadic APA. The identification of these mutations have allowed the establishment of a model for APA development involving modifications in the intracellular ionic equilibrium and in the regulation of cell membrane potential, leading to autonomous aldosterone overproduction...
April 11, 2017: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/28398499/outcome-of-elderly-patients-with-diffuse-large-b-cell-lymphoma-treated-with-r-chop-results-from-the-uk-ncri-r-chop14v21-trial-with-combined-analysis-of-molecular-characteristics-with-the-dshnhl-ricover-60-trial
#16
A Kühnl, D Cunningham, N Counsell, E A Hawkes, W Qian, P Smith, N Chadwick, A Lawrie, P Mouncey, A Jack, C Pocock, K M Ardeshna, J Radford, A McMillan, J Davies, D Turner, A Kruger, P Johnson, J Gambell, A Rosenwald, G Ott, H Horn, M Ziepert, M Pfreundschuh, D Linch
BACKGROUND: There is an on-going debate whether 2- or 3-weekly administration of R-CHOP is the preferred first-line treatment for elderly patients with diffuse large B-cell lymphoma (DLBCL). The UK NCRI R-CHOP14v21 randomized phase 3 trial did not demonstrate a difference in outcomes between R-CHOP-14 and R-CHOP-21 in newly diagnosed DLBCL patients aged 19-88 years, but data on elderly patients have not been reported in detail so far. Here, we provide a subgroup analysis of patients ≥60 years treated on the R-CHOP14v21 trial with extended follow-up...
April 7, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28382141/overexpression-of-myc-and-bcl2-predicts-poor-prognosis-in-patients-with-extranodal-nk-t-cell-lymphoma-nasal-type
#17
Jing-Hua Wang, Xi-Wen Bi, Peng-Fei Li, Zhong-Jun Xia, Hui-Qiang Huang, Wen-Qi Jiang, Yu-Jing Zhang, Liang Wang
Background: Recently double-hit lymphoma or double protein expressor lymphoma has been identified as a distinct group of diffuse large B cell lymphoma with poor prognosis. However, the expression status, clinical and prognostic effect of combined overexpression of MYC and BCL2 in extranodal NK/T-cell lymphoma, nasal type (ENKTL) are not known. Materials and methods: Paraffin-embedded lymphoma samples from 53 patients with newly diagnosed ENKTL were studied using immunohistochemistry for MYC and BCL2, and fluorescent in situ hybridization (FISH) for MYC and BCL2 were done on 5 tissue sections with highest percentages of both MYC and BCL2 positive lymphoma cells...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28379189/the-role-of-c-myc-in-b-cell-lymphomas-diagnostic-and-molecular-aspects
#18
REVIEW
Lynh Nguyen, Peter Papenhausen, Haipeng Shao
c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is essential in the pathogenesis of a number of B-cell lymphomas, but is rarely reported in T-cell lymphomas. c-MYC dysregulation induces lymphomagenesis by loss of the tight control of c-MYC expression, leading to overexpression of intact c-MYC protein, in contrast to the somatic mutations or fusion proteins seen in many other oncogenes...
April 5, 2017: Genes
https://www.readbyqxmd.com/read/28378514/donor-promiscuity-of-a-thermostable-transketolase-by-directed-evolution-efficient-complementation-of-1-deoxy-d-xylulose-5-phosphate-synthase-activity
#19
Thangavelu Saravanan, Sebastian Junker, Michael Kickstein, Sascha Hein, Marie-Kristin Link, Jan Ranglack, Samantha Witt, Marion Lorillière, Laurence Hecquet, Wolf-Dieter Fessner
Enzymes catalyzing asymmetric carboligation reactions typically show very high substrate specificity for their nucleophilic donor substrate components. Structure-guided engineering of the thermostable transketolase from Geobacillus stearothermophilus by directed in vitro evolution yielded new enzyme variants that are able to utilize pyruvate and higher aliphatic homologues as nucleophilic components for acyl transfer instead of the natural polyhydroxylated ketose phosphates or hydroxypyruvate. The single mutant H102T proved the best hit toward 3-methyl-2-oxobutyrate as donor, while the double variant H102L/H474S showed highest catalytic efficiency toward pyruvate as donor...
May 2, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28357165/persistent-afebrile-abdominal-pain-an-unusual-case-of-segmental-colitis-in-an-immunocompromised-host
#20
Ilias P Papakonstantinou, Emmanuel A Andreadis
In this report we describe a case of a 66-year-old woman who presented with right upper quadrant abdominal pain and bloody diarrhea. A workup revealed immunodeficiency, an immunologic profile with low complement levels resembling systemic lupus erythematosus, and a circumferential colonic wall lesion located in the ascending colon. After endoscopy and biopsy, the mass lesion was attributed to "double hit" diffuse large B-cell lymphoma, categorized as high grade large B-cell non-Hodgkin lymphoma according to the most recent revised 2016 World Health Organisation classification and considered to be a rare and highly aggressive tumor...
February 16, 2017: Curēus
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