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https://www.readbyqxmd.com/read/27265421/gabapentin-misuse-abuse-and-diversion-a-systematic-review
#1
REVIEW
Rachel V Smith, Jennifer R Havens, Sharon L Walsh
BACKGROUND AND AIMS: Since its market release, gabapentin has been presumed to have no abuse potential and subsequently has been prescribed widely off-label, despite increasing reports of gabapentin misuse. This review estimates and describes the prevalence and effects of, motivations behind and risk factors for gabapentin misuse, abuse and diversion. METHODS: Databases were searched for peer-reviewed papers demonstrating gabapentin misuse, characterized by taking a larger dosage than prescribed or taking gabapentin without a prescription, and diversion...
July 2016: Addiction
https://www.readbyqxmd.com/read/27065581/analyzing-relationship-between-monoclonal-gammopathy-of-undetermined-significance-mgus-with-different-types-of-neuropathy-an-observational-study
#2
Shahzaib Nabi, Pushpinderdeep Kahlon, Farshid Bozorgnia, Adeel Arshad, Akmam Saleem, Philip Kuriakose
To analyze multiple variables, including immunoglobulin subtypes in patients with monoclonal gammopathy of undetermined significance (MGUS) and different types of neuropathy. This was a retrospective, single center study done in a tertiary care hospital in the United States. The data was collected for years 2001-2011. Inclusion criteria were the presence of MGUS and neuropathy. Exclusion criteria were the presence of other factors such as diabetes, vitamin B12 deficiency, alcoholism etc. which can cause neuropathy...
June 2016: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/26977830/medications-for-alcohol-use-disorder
#3
Bradford T Winslow, Mary Onysko, Melanie Hebert
The U.S. Preventive Services Task Force recommends that clinicians screen adults for alcohol misuse and provide persons engaged in risky or hazardous drinking behaviors with brief behavioral counseling to reduce alcohol misuse. However, only a minority of American adults with high-risk alcohol use receive treatment. Three medications are approved by the U.S. Food and Drug Administration to treat alcohol use disorder: acamprosate, disulfiram, and naltrexone. Acamprosate and naltrexone reduce alcohol consumption and increase abstinence rates, although the effects appear to be modest...
March 15, 2016: American Family Physician
https://www.readbyqxmd.com/read/26946710/-pharmacovigilance-update
#4
Kim Dao, Haithem Chtioui, Laura E Rothuizen, Léonore Diezi, Sylvain Prod'hom, Ursula Winterfeld, Thierry Buclin, Françoise Livio
The main pharmacovigilance updates in 2015are reviewed. Sofosbuvir amiodarone interaction: risk of severe bradycardia. Dasabuvir clopidogrel interaction: increased dasabuvir concentrations and potential risk of QTprolongation. SGLT2 inhibitors: risks of diabetic acidocetosis and bone fracture. Dabigatran: therapeutic drug monitoring may improve benefit-risk ratio. Ibuprofen: at higher dosage, vascular risks are comparable to coxibs. Pregabaline, gabapentine: potential for abuse and addiction. Varenicline: potentiates alcohol's effects...
January 13, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/26928397/potential-medications-for-the-treatment-of-alcohol-use-disorder-an-evaluation-of-clinical-efficacy-and-safety
#5
Raye Z Litten, Bonnie B Wilford, Daniel E Falk, Megan L Ryan, Joanne B Fertig
Alcohol use disorder (AUD), as currently defined in the Diagnostic and Statistical Manual, 5th Edition (DSM-5), is a heterogeneous disorder stemming from a complex interaction of neurobiological, genetic, and environmental factors. As a result of this heterogeneity, there is no one treatment for AUD that will work for everyone. During the past 2 decades, efforts have been made to develop a menu of medications to give patients and clinicians more choices when seeking a therapy that is both effective and which has limited side effects...
April 2016: Substance Abuse
https://www.readbyqxmd.com/read/26887855/abuse-of-gabapentin-is-associated-with-opioid-addiction
#6
Leo Bastiaens, James Galus, Cherise Mazur
The objective of this study was to evaluate the extent of gabapentin misuse in a dually diagnosed correctional population, and to evaluate if this abuse is specific to the presence of an opioid use disorder (OUD). Two-hundred and fifty former inmates, living in a correctional community center, who were referred for a psychiatric evaluation, were asked, through a brief written questionnaire, whether or not they used the following drugs for non-medical use in the past: opiates, gabapentin, buproprion, quetiapine, and fluoxetine...
February 18, 2016: Psychiatric Quarterly
https://www.readbyqxmd.com/read/26768934/treatment-of-patients-with-painful-blind-eye-using-stellate-ganglion-block
#7
Tatiana Vaz Horta Xavier, Thiago Robis de Oliveira, Tereza Cristina Bandeira Silva Mendes
BACKGROUND AND OBJECTIVES: management of pain in painful blind eyes is still a challenge. Corticosteroids and hypotensive agents, as well as evisceration and enucleation, are some of the strategies employed so far that are not always effective and, depending on the strategy, cause a deep emotional shock to the patient. Given these issues, the aim of this case report is to demonstrate a new and viable option for the management of such pain by treating the painful blind eye with the stellate ganglion block technique, a procedure that has never been described in the literature for this purpose...
January 2016: Brazilian Journal of Anesthesiology
https://www.readbyqxmd.com/read/26721643/gabapentin-abuse-dependence-and-withdrawal
#8
REVIEW
Tracey L Mersfelder, William H Nichols
OBJECTIVE: To identify case reports and studies regarding patients who abused, became dependent on, or experienced withdrawal from gabapentin. DATA SOURCES: A PubMed literature search (1993 to October 2015) was performed using the search terms gabapentin, withdrawal, dependence, and addiction. Additional references were identified from a review of literature citations. STUDY SELECTION: All English-language case reports and studies were evaluated...
March 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/26664156/approach-to-the-pharmacological-management-of-chronic-pain-in-patients-with-an-alcohol-use-disorder
#9
Laura Murphy, Karen Wk Ng, Victoria Ch Su, Sarah Woodworth-Giroux, Todd S Levy, Beth A Sproule, Andrea D Furlan
This paper provides an overview of research, guidelines, and clinical considerations for the use of medications for chronic pain in the management of patients with an alcohol use disorder. A review of the literature identified randomized controlled trials, epidemiological cohort studies, consensus guidelines, and one systematic review and meta-analysis. Where gaps in the literature existed, clinical experience of the authors is included. Use of nonopioid medications should be given priority and may offer a more favorable risk profile as well as benefits beyond pain management, such as improvement in anxiety, depression, or insomnia...
2015: Journal of Pain Research
https://www.readbyqxmd.com/read/26415538/gabapentin-potentiates-sensitivity-to-the-interoceptive-effects-of-alcohol-and-increases-alcohol-self-administration-in-rats
#10
Joyce Besheer, Suzanne Frisbee, Patrick A Randall, Anel A Jaramillo, Maria Masciello
Gabapentin, a drug used in the treatment of epileptic seizures and neuropathic pain, has shown efficacy in the treatment of alcohol dependence. Moreover, given that gabapentin is used in the general population (e.g., non-dependent individuals, social drinkers), we sought to utilize preclinical assessments to examine the effects of gabapentin on sensitivity to moderate alcohol doses and alcohol self-administration in rats with a history of moderate drinking. To this end, we assessed whether gabapentin (0, 10, 30, 120 mg/kg, IG) pretreatment alters sensitivity to experimenter- and self-administered alcohol, and whether gabapentin alone has alcohol-like discriminative stimulus effects in rats trained to discriminate alcohol dose (1 g/kg, IG) vs...
February 2016: Neuropharmacology
https://www.readbyqxmd.com/read/26088121/gabab-agonists-for-the-treatment-of-alcohol-use-disorder
#11
REVIEW
Antonio Mirijello, Fabio Caputo, Gabriele Vassallo, Benjamin Rolland, Claudia Tarli, Antonio Gasbarrini, Giovanni Addolorato
Almost 10% of the world's population is affected by alcohol use disorder (AUD). The combination between psychosocial intervention and pharmacological treatment seems to be the most effective approach for patients affected by AUD. Among effective drugs useful in the treatment of AUD, GABAB-ergic medications have been tested with encouraging results (i.e. sodium oxybate, baclofen, gabapentin, pregabalin and tiagabine). The present review will summarize available data on these medications.
2015: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/25969570/the-role-of-gabapentin-in-the-management-of-alcohol-withdrawal-and-dependence
#12
REVIEW
Jonathan G Leung, Daniel Hall-Flavin, Sarah Nelson, Kristen A Schmidt, Kathryn M Schak
OBJECTIVE: To review the literature evaluating gabapentin for alcohol withdrawal and dependence. DATA SOURCES: A literature search of MEDLINE (1966 to end of March 2015) and PubMed was performed using the terms alcohol, gabapentin, withdrawal, and dependence. Additional references were identified from a review of literature citations. STUDY SELECTION AND DATA EXTRACTION: English-language prospective studies evaluating gabapentin for alcohol withdrawal and dependence were evaluated...
August 2015: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/25918198/benzodiazepine-in-a-urine-specimen-without-drug-metabolites
#13
Thomas Kampfrath, Penny Peng, Valli Vairavan, Dayong Lee
CLINICAL HISTORY: HASH(0x459ef70) PATIENT: 41-year-old Hispanic woman. Chief Complaint: Pain in the neck, joints, and shoulders that started in August 2013. History of Present Illness: The patient has a history of psychiatric illness. Her primary care physician from an outside facility had prescribed alprazolam (Xanax) to treat her depression. The patient reported that in 2011 she experienced pain in the right side of her back and was diagnosed with sciatica. In addition, she was diagnosed with systemic lupus erythematosus (SLE) based on a positive finding for antinuclear antibodies (ANA) and double-stranded DNA (ds-DNA)...
2015: Laboratory Medicine
https://www.readbyqxmd.com/read/25882271/anticonvulsants-for-cocaine-dependence
#14
REVIEW
Silvia Minozzi, Michela Cinquini, Laura Amato, Marina Davoli, Michael F Farrell, Pier Paolo Pani, Simona Vecchi
BACKGROUND: Cocaine dependence is a major public health problem that is characterised by recidivism and a host of medical and psychosocial complications. Although effective pharmacotherapy is available for alcohol and heroin dependence, none is currently available for cocaine dependence, despite two decades of clinical trials primarily involving antidepressant, anticonvulsivant and dopaminergic medications. Extensive consideration has been given to optimal pharmacological approaches to the treatment of individuals with cocaine dependence, and both dopamine antagonists and agonists have been considered...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25864607/prescription-medication-misuse-among-opioid-dependent-patients-seeking-inpatient-detoxification
#15
COMPARATIVE STUDY
Timothy Wilens, Courtney Zulauf, Denece Ryland, Nicholas Carrellas, Isela Catalina-Wellington
BACKGROUND AND OBJECTIVES: Opioid related morbidity and mortality is heightened in context to the concomitant use of psychotropic medications. The aim of this project was to examine the extent to which opioid dependent patients seeking detoxification are using and misusing specific psychotropic agents. METHODS: As part of a quality assurance/improvement project, we systematically assessed prospectively consecutive admissions to a public detoxification program using a self-report questionnaire to query for specific psychotropic medication use...
March 2015: American Journal on Addictions
https://www.readbyqxmd.com/read/25810840/a-retrospective-study-of-72-cases-diagnosed-with-idiopathic-trigeminal-neuralgia-in-indian-populace
#16
Sunil Yadav, Hitesh-Chander Mittal, Akash Sachdeva, Ajay Verma, Vikas Dhupar, Anita Dhupar
CONTEXT: Trigeminal neuralgia is as a chronic, debilitating condition, which can have a major impact on quality of life. There are few reports of trigeminal neuralgia in oriental populations. OBJECTIVES: To evaluate the retrospective data of the patients diagnosed with idiopathic trigeminal neuralgia and to understanding the disorder in the Indian populace. METHODS: The retrospective data of 72 patients with typical idiopathic trigeminal neuralgia regarding age of onset, gender, site of involvement, clinical presentations and treatment received during three years of the follow up was collected and analyzed...
February 2015: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/25761458/recent-developments-in-pharmacotherapy-of-alcoholism
#17
REVIEW
M Soyka, M Lieb
INTRODUCTION: Alcohol use disorders are common, but only a small minority of patients receive adequate treatment. Cognitive-behavioural therapies, motivational enhancement interviewing and brief interventions are established treatments, but few pharmacotherapies are available. AREAS COVERED: This narrative focuses on the neurobiological basis of alcohol use disorders and on emerging drugs that either have recently been approved or look likely to find their way into clinical practice...
July 2015: Pharmacopsychiatry
https://www.readbyqxmd.com/read/25731153/withdrawn-anticonvulsants-for-cocaine-dependence
#18
REVIEW
Silvia Minozzi, Laura Amato, Marina Davoli, Michael F Farrell, Anelise A R L Lima Reisser, Pier Paolo Pani, Mauricio Silva de Lima, Bernardo G O Soares, Simona Vecchi
No abstract text is available yet for this article.
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25666543/identification-and-management-of-alcohol-withdrawal-syndrome
#19
REVIEW
Antonio Mirijello, Cristina D'Angelo, Anna Ferrulli, Gabriele Vassallo, Mariangela Antonelli, Fabio Caputo, Lorenzo Leggio, Antonio Gasbarrini, Giovanni Addolorato
Symptoms of alcohol withdrawal syndrome (AWS) may develop within 6-24 h after the abrupt discontinuation or decrease of alcohol consumption. Symptoms can vary from autonomic hyperactivity and agitation to delirium tremens. The gold-standard treatment for AWS is with benzodiazepines (BZDs). Among the BZDs, different agents (i.e., long-acting or short-acting) and different regimens (front-loading, fixed-dose or symptom-triggered) may be chosen on the basis of patient characteristics. Severe withdrawal could require ICU admission and the use of barbiturates or propofol...
March 2015: Drugs
https://www.readbyqxmd.com/read/25409541/prescription-medication-misuse-among-opioid-dependent-patients-seeking-inpatient-detoxification
#20
Timothy Wilens, Courtney Zulauf, Denece Ryland, Nicholas Carrellas, Isela Catalina-Wellington
BACKGROUND AND OBJECTIVES: Opioid related morbidity and mortality is heightened in context to the concomitant use of psychotropic medications. The aim of this project was to examine the extent to which opioid dependent patients seeking detoxification are using and misusing specific psychotropic agents. METHODS: As part of a quality assurance/improvement project, we systematically assessed prospectively consecutive admissions to a public detoxification program using a self-report questionnaire to query for specific psychotropic medication use...
November 19, 2014: American Journal on Addictions
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