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Pregnancy associated plasma protein a

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https://www.readbyqxmd.com/read/28544689/class-ii-obese-and-healthy-pregnant-controls-exhibit-indistinguishable-pro-and-anti-inflammatory-immune-responses-to-caesarian-section
#1
Caroline Graham, Mullein Thorleifson, William P Stefura, Duane J Funk, Kent T HayGlass
INTRODUCTION: Obesity during pregnancy is associated with meta-inflammation and an increased likelihood of clinical complications. Surgery results in intense, acute inflammatory responses in any individual. Because obese individuals exhibit constitutive inflammatory responses and high rates of Caesarian section, it is important to understand the impact of surgery in such populations. Whether more pronounced pro-inflammatory cytokine responses and/or counterbalancing changes in anti-inflammatory immune modulators occurs is unknown...
May 25, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/28537443/pregnancy-associated-plasma-protein-a-papp-a-and-the-proform-of-the-eosinophil-major-basic-protein-prombp-are-associated-with-increased-risk-of-death-in-heart-failure-patients
#2
Maja Dembic, Paula L Hedley, Christian Torp-Pedersen, Lars Køber, Michael Christiansen
Risk stratification and patient management in heart failure (HF) is difficult due to the unpredictable progression of the disease, necessitating the development of reliable diagnostic biomarkers to facilitate decision-making in clinical practice. Pregnancy-associated plasma protein-A (PAPP-A) is a marker of arteriosclerotic heart disease. PAPP-A is a serum protease, which is involved in the insulin-like growth factor 1 (IGF-1) axis where it is inhibited by the proform of the eosinophil major basic protein (proMBP)...
May 24, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28515164/mrna-levels-of-placental-iron-and-zinc-transporter-genes-are-upregulated-in-gambian-women-with-low-iron-and-zinc-status
#3
Modou Lamin Jobarteh, Harry J McArdle, Grietje Holtrop, Ebrima A Sise, Andrew M Prentice, Sophie E Moore
Background: The role of the placenta in regulating micronutrient transport in response to maternal status is poorly understood.Objective: We investigated the effect of prenatal nutritional supplementation on the regulation of placental iron and zinc transport.Methods: In a randomized trial in rural Gambia [ENID (Early Nutrition and Immune Development)], pregnant women were allocated to 1 of 4 nutritional intervention arms: 1) iron and folic acid (FeFol) tablets (FeFol group); 2) multiple micronutrient (MMN) tablets (MMN group); 3) protein energy (PE) as a lipid-based nutrient supplement (LNS; PE group); and 4) PE and MMN (PE+MMN group) as LNS...
May 17, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28514830/association-of-maternal-serum-papp-a-levels-nuchal-translucency-and-crown-rump-length-in-first-trimester-with-adverse-pregnancy-outcomes-retrospective-cohort-study
#4
Ashwini Bilagi, Danielle L Burke, Richard D Riley, Ian Mills, Mark D Kilby, R Katie Morris
OBJECTIVE: Are first trimester serum pregnancy-associated plasma protein-A (PAPP-A), nuchal translucency (NT) and crown rump length (CRL) prognostic factors for adverse pregnancy outcomes? METHOD: Retrospective cohort women, singleton pregnancies (UK 2011-2015). Unadjusted and multivariable logistic regression, outcomes: small for gestational age (SGA), pre-eclampsia (PE), pre-term birth (PTB), miscarriage, stillbirth, perinatal mortality and neonatal death (NND)...
May 17, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28502787/no-association-detected-between-seven-common-variants-in-the-cdkal1-gene-and-gestational-glycemic-traits
#5
Hongfang Ju, Rong Lin, Ziyu Yuan, Yuantian Sun, Liangliang Zeng, Zhenyu Su, Li Jin
Elevated plasma glucose levels in pregnancy increase adverse pregnancy outcomes. Cyclin-dependent kinase 5 regulatory subunit-associated protein 1-like 1 (CDKAL1) has been shown to be involved in insulin secretion in pancreatic β cells. In this study, we investigated the impact of genetic variants in CDKAL1 on plasma glucose, insulin values, β cell function and insulin resistance in the fasted state as well as plasma glucose 1 h after the consumption of a 50-g oral glucose load between 24 and 28 weeks of pregnancy among 929 unrelated pregnant Han Chinese women...
May 11, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28501799/high-maternal-expression-of-siglec1-on-monocytes-as-a-surrogate-marker-of-a-type-i-interferon-signature-is-a-risk-factor-for-the-development-of-autoimmune-congenital-heart-block
#6
Anna R Lisney, Franziska Szelinski, Karin Reiter, Gerd R Burmester, Thomas Rose, Thomas Dörner
OBJECTIVES: Autoimmune congenital heart block (CHB) is associated with placental transcytosis of maternal autoantibodies directed against Ro/SS-A and La/SS-B. However, only about 2% of children born to mothers with the respective antibodies are affected, indicating that further risk factors exist, which are not yet fully understood. In this study, we investigated whether a maternal type I interferon (IFN) signature represents a risk factor for the development of CHB. METHODS: Blood samples, clinical data and serological parameters from 9 women with CHB pregnancies, 14 pregnant women with antibodies against Ro/SS-A but without a CHB complication and another 30 healthy pregnant women as controls were studied...
May 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28498795/comparison-of-fetal-weight-distribution-improved-by-paternal-height-by-spanish-standard-versus-intergrowth-21st-standard
#7
Ricardo Savirón-Cornudella, Luis Mariano Esteban, Diego Lerma, Laura Cotaina, Ángel Borque, Gerardo Sanz, Sergio Castán
OBJECTIVE: Our main objective was to study the influence on birth and ultrasound fetal weight of traditional factors in combination with non-traditionally explored predictors such as paternal height to provide a new customized in utero growth model. We also have compared it in our population with other customized and non-customized models. METHODS: We collected 5243 cases of singleton pregnancies. An integrated study of the different variables was performed in a multivariate model to predict the fetus birthweight and customized growth curves were created following the Gardosi procedure...
May 12, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/28491088/novel-biomarkers-for-cardiovascular-risk-prediction
#8
REVIEW
Juan Wang, Guo-Juan Tan, Li-Na Han, Yong-Yi Bai, Miao He, Hong-Bin Liu
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. The primary prevention of CVD is dependent upon the ability to identify high-risk individuals long before the development of overt events. This highlights the need for accurate risk stratification. An increasing number of novel biomarkers have been identified to predict cardiovascular events. Biomarkers play a critical role in the definition, prognostication, and decision-making regarding the management of cardiovascular events...
February 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28490175/prenatal-nonylphenol-and-bisphenol-a-exposures-and-inflammation-are-determinants-of-oxidative-nitrative-stress-a-taiwanese-cohort-study
#9
Yu-Fang Huang, Pei-Wei Wang, Li-Wei Huang, Chun-Hao Lai, Winnie Yang, Kuen-Yuh Wu, Chensheng Alex Lu, Hsin-Chang Chen, Mei-Lien Chen
Prenatal exposure to nonylphenol (NP) and/or bisphenol A (BPA) has been reported to be associated with adverse birth outcomes; however, the underlying mechanisms remain unclear. The primary mechanism is endocrine disruption of the binding affinity for the estrogen receptor, but oxidative stress and inflammation might also play a contributory role. We aimed to investigate urinary NP and BPA levels in relation to biomarkers of oxidative/nitrative stress and inflammation and to explore whether changes in oxidative/nitrative stress are a function of prenatal exposure to NP/BPA and inflammation in 241 mother-fetus pairs...
May 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28470791/impaired-placentation-in-women-with-chronic-hypertension-that-develop-preeclampsia
#10
Anca M Panaitescu, Ranjit Akolekar, Nicholas Kametas, Argyro Syngelaki, Kypros H Nicolaides
OBJECTIVE: To compare the degree of impaired placentation in pregnancies which develop preeclampsia (PE) in women with and without chronic hypertension (CH). METHODS: The data for this study were derived from prospective screening for adverse pregnancy outcomes in women with singleton pregnancies attending for their first routine hospital visit at 11(+0) -13(+6) weeks' gestation. This visit included recording of maternal characteristics and medical history and measurements of mean arterial pressure (MAP), uterine artery pulsatility index (UTPI), serum placental growth factor (PLGF) and serum pregnancy associated plasma protein-A (PAPP-A)...
May 4, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28454217/paraganglioma-of-the-organ-of-zuckerkandl-associated-with-a-somatic-hif2%C3%AE-mutation-a-case-report
#11
Ahmad Esmaeel Abdullah, Carole Guerin, Alessio Imperiale, Anne Barlier, Stéphanie Battini, Morgane Pertuit, Philippe Roche, Wassim Essamet, Bernard Vaisse, Karel Pacak, Fréderic Sebag, David Taïeb
Paragangliomas of the organ of Zuckerkandl (OZ-PGL) are rare tumors that, in >70% of cases, occur in association with succinate dehydrogenase complex iron sulfur subunit B (SDHB) or SDHD gene mutations. The aim of the current study was to determine whether a somatic genetic defect in the hypoxia-inducible factor 2α (HIF2α) gene was present in a case of sporadic OZ-PGL. A 32-year-old African female presented with uncontrolled hypertension during the first trimester of pregnancy. A diagnostic hysteroscopy was performed 3 months after delivery, precipitating a hypertensive crisis...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28451695/low-maternal-serum-pregnancy-associated-plasma-protein-a-as-a-risk-factor-of-preeclampsia
#12
Suchaya Luewan, Monrudee Teja-Intr, Supatra Sirichotiyakul, Theera Tongsong
INTRODUCTION: Low levels of pregnancy-associated plasma protein-A (PAPP-A) might be associated with abnormal placentation, leading to the development of preeclampsia in late gestation. We aimed to determine the association between low serum PAPP-A levels and rates of preeclampsia in Thai women with otherwise low-risk pregnancies. METHODS: A cohort study was conducted on consecutive singleton pregnancies, undergoing first trimester screening for fetal Down syndrome, at a tertiary centre hospital...
April 28, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28445440/micronutrient-status-among-pregnant-women-in-zinder-niger-and-risk-factors-associated-with-deficiency
#13
K Ryan Wessells, Césaire T Ouédraogo, Rebecca R Young, M Thierno Faye, Alex Brito, Sonja Y Hess
Anemia and micronutrient (MN) deficiencies in pregnant women are associated with adverse pregnancy outcomes. In Niger, 58.6% of pregnant women are anemic; however, MN statuses are unknown. The study objectives were to estimate the prevalence of MN deficiencies among pregnant women in Zinder, Niger and explore associated risk factors. Pregnant women living in randomly selected rural villages (n = 88) were included. Capillary and venous blood samples (n = 770) were analyzed for hemoglobin (Hb) and plasma ferritin, soluble transferrin receptor (sTfR), zinc (pZn), retinol binding protein (RBP), folate and vitamin B12...
April 26, 2017: Nutrients
https://www.readbyqxmd.com/read/28428000/selected-oxidative-stress-biomarkers-in-antenatal-diagnosis-as-11-14-gestational-weeks
#14
Marek Pietryga, Piotr Dydowicz, Kinga Toboła, Marta Napierała, Izabela Miechowicz, Anna Gąsiorowska, Maciej Brązert, Ewa Florek
The primary objective in modern obstetrics and prenatal diagnosis is to predict risks of congenital abnormalities. The aim of the research was to assess the correlation between selected oxidative stress biomarkers with the risk of foetal chromosomal aberration evaluated at the first trimester screening. A series of studies show that balanced free radical activity and oxidative homeostasis are essential for proper bodily growth and function. Reactive oxygen species (ROS) may be one of the factors associated with disruption of cell cycle and tissue development, thus leading to developmental abnormalities...
April 18, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28423979/pregnancy-associated-plasma-protein-a-truncation-limits-in-antenatal-screening-for-trisomy-18
#15
J P Bestwick, W J Huttly, N J Wald
Upper and lower truncation limits are commonly applied to quantitative markers used in medical screening tests. We here examine data on 375 trisomy 18 and 522,081 unaffected singleton pregnancies, to determine if the lower truncation limit should be set below the previously specified 0.2 multiples of the median. A lower truncation limit of 0.15 would reduce the underestimation of the risk of having a trisomy 18 pregnancy in about 50% of affected pregnancies and would lead to an estimated 10 percentage point increase in the detection rate, with only a very small increase in the false-positive rate...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28410520/maternal-and-infant-inflammatory-markers-in-relation-to-prenatal-arsenic-exposure-in-a-u-s-pregnancy-cohort
#16
Shohreh F Farzan, Elizabeth B Brickley, Zhigang Li, Diane Gilbert-Diamond, Anala Gossai, Yu Chen, Caitlin G Howe, Thomas Palys, Margaret R Karagas
INTRODUCTION: Accumulating evidence indicates that arsenic (As), a potent environmental toxicant, may increase cardiovascular disease risk and adversely affect endothelial function at high levels of exposure. Pregnancy is a vulnerable time for both mother and child; however, studies examining the association between prenatal As exposure and plasma biomarkers of inflammation and endothelial function in mothers and newborns are lacking. METHODS: We examined maternal urinary As levels at gestational weeks 24-28 and levels of inflammatory biomarkers in plasma from 563 pregnant women and 500 infants' cord blood...
April 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/28405801/urine-exosomes-from-healthy-and-hypertensive-pregnancies-display-elevated-level-of-%C3%AE-subunit-and-cleaved-%C3%AE-and-%C3%AE-subunits-of-the-epithelial-sodium-channel-enac
#17
Maria R Nielsen, Britta Frederiksen-Møller, Rikke Zachar, Jan S Jørgensen, Mie R Hansen, Rikke Ydegaard, Per Svenningsen, Kristian Buhl, Boye L Jensen
Preeclampsia is characterized by hypertension, proteinuria, suppression of plasma renin-angiotensin-aldosterone, and impaired urine sodium excretion. Aberrantly filtered plasmin in urine may activate proteolytically the γ-subunit of the epithelial sodium channel (ENaC) and promote Na(+) reabsorption and urine K(+) loss. Plasma and urine was sampled from patients with preeclampsia, healthy pregnant controls and non-pregnant women, and from patients with nephrostomy catheters. Aldosterone concentration, urine plasminogen, and protein were determined...
April 12, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28397320/pregnancy-associated-plasma-protein-a-is-positively-correlated-to-first-trimester-skin-microvascular-reactivity
#18
C Iacobaeus, T Kahan, G Jörneskog, K Bremme, E Andolf, M Thorsell
OBJECTIVE: To investigate if there is a correlation between levels of circulating maternal pregnancy-associated plasma protein A (PAPP-A) and first trimester maternal vascular function. METHODS: A cross-sectional study of 53 healthy non-smoking, pregnant, nulliparous women in Stockholm, Sweden. PAPP-A and vascular function were assessed during gestational week 11-14. Forearm skin microcirculation was investigated by laser Doppler perfusion imaging during iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) to assess endothelium dependent and endothelium independent microvascular vasodilatation, respectively...
April 11, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28395333/ovine-uterine-space-restriction-causes-dysregulation-of-the-renin-angiotensin-system-in-fetal-kidneys%C3%A2
#19
Rachel A Kranch-Shorthouse, Adam S Bauer, Ronald R Magness, Gladys E Lopez, Jeffrey L Segar, Sharon E Blohowiak, Pamela J Kling
In ovine pregnancy, uterine space restriction (USR) resulting from decreased space for placental attachment caused intrauterine growth restriction and impaired nephrogenesis. The fetal kidney renin-angiotensin system (RAS) is involved in nephrogenesis, fluid balance, and iron deposition. Angiotensin II exerts its effects via multiple receptors: angiotensin II 1-8 receptor type 1 (AT 1 R) and type 2 (AT 2 R), and angiotensin II 1-7 Mas receptor (MASR). Objective: : To test the hypothesis that ovine USR is associated with dysregulation of the fetal renal RAS...
January 1, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/28387061/gestational-diabetes-mellitus-and-first-trimester-pregnancy-associated-plasma-protein-a-a-case-control-study-in-a-chinese-population
#20
Di Xiao, Chenhong Wang, Yanbin Xu, Zhou Lu
AIMS: To investigate the relationship between pregnancy-associated plasma protein A (PAPP-A) and gestational diabetes mellitus (GDM) and to determine whether PAPP-A has improved value for predicting GDM in a Chinese population. METHODS: Clinical data for 599 GDM patients and 986 unaffected pregnant women undergoing both antenatal examinations and delivery were retrospectively analyzed. First-trimester serum PAPP-A levels were compared between the groups. Binary logistic regression analysis was used to explore the risk factors for GDM, and the area under the receiver operating characteristic (AUC-ROC) curve was used to determine the value of PAPP-A for predicting GDM...
April 7, 2017: Journal of Diabetes Investigation
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