keyword
https://read.qxmd.com/read/38289491/obsessive-compulsive-symptoms-and-brain-lesions-compatible-with-multiple-sclerosis
#21
JOURNAL ARTICLE
Katharina von Zedtwitz, Ludger Tebartz van Elst, Horst Urbach, Sergiu Groppa, Miriam A Schiele, Harald Prüss, Katharina Domschke, Oliver Stich, Luciana Hannibal, Dominique Endres
Autoimmune-mediated obsessive-compulsive disorder (OCD) can occur in multiple sclerosis (MS). Here, a well-studied case study of a patient with OCD and MS-compatible diagnostic findings is presented. The 42-year-old female patient had displayed OCD symptoms for 6 years. Magnetic resonance imaging (MRI) identified several periventricular and one brainstem lesion suggestive of demyelination. Cerebrospinal fluid (CSF) analyses detected an increased white blood cell count, intrathecal immunoglobulin (Ig) G and IgM synthesis, CSF-specific oligoclonal bands, and a positive MRZ reaction...
January 30, 2024: Journal of Neural Transmission
https://read.qxmd.com/read/38285456/multiomic-analysis-of-neuroinflammation-and-occult-infection-in-sudden-infant-death-syndrome
#22
JOURNAL ARTICLE
Prashanth S Ramachandran, Benjamin W Okaty, Molly Riehs, Anne Wapniarski, Daniel Hershey, Hani Harb, Maham Zia, Elisabeth A Haas, Sanda Alexandrescu, Lynn A Sleeper, Sara O Vargas, Mark P Gorman, Steven Campman, Othon J Mena, Keith Levert, Keith Hyland, Richard D Goldstein, Michael R Wilson, Robin L Haynes
IMPORTANCE: Antemortem infection is a risk factor for sudden infant death syndrome (SIDS)-the leading postneonatal cause of infant mortality in the developed world. Manifestations of infection and inflammation are not always apparent in clinical settings or by standard autopsy; thus, enhanced resolution approaches are needed. OBJECTIVE: To ascertain whether a subset of SIDS cases is associated with neuroinflammation and occult infection. DESIGN, SETTING, AND PARTICIPANTS: In this case-control study, postmortem fluids from SIDS cases and controls collected between July 2011 and November 2018 were screened for elevated inflammatory markers, specifically cerebrospinal fluid (CSF) neopterin and CSF and serum cytokines...
January 29, 2024: JAMA Neurology
https://read.qxmd.com/read/38282545/analysis-of-tryptophan-metabolites-and-related-compounds-in-human-and-murine-tissue-development-and-validation-of-a-quantitative-and-semi-quantitative-method-using-high-resolution-mass-spectrometry
#23
JOURNAL ARTICLE
Sandy Abujrais, S J Kumari A Ubhayasekera, Jonas Bergquist
This study explores the metabolic differences between human and murine plasma in addition to differences between murine subcutaneous and visceral white adipose tissue. A quantitative and semi-quantitative targeted method was developed and validated for this purpose. The quantitative method includes tryptophan and its metabolites in addition to tyrosine, phenylalanine, taurine, B vitamins, neopterin, cystathionine and hypoxanthine. While the semi-quantitative method includes; 3-indoleacetic acid, 5-hydroxyindoleacetic acid, acetylcholine, asymmetric dimethylarginine, citrulline and methionine...
January 29, 2024: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/38247273/serum-neopterin-biopterin-tryptophan-and-kynurenine-levels-in-patients-with-fabry-disease
#24
JOURNAL ARTICLE
Tuğçe Uçar, Mehmet Şerif Cansever, Esra Isat, Tanyel Zubarioğlu, Ayşe Çiğdem Aktuğlu Zeybek, Birol Topçu, Nurhan Seyahi, Ertuğrul Kıykım
BACKGROUND: Fabry disease is characterized by the accumulation of globotriaosylceramide. Substrate accumulation in lysosomes is thought to trigger an inflammatory response and is responsible for progressive organ damage through the induction of autoimmunity. The levels of pteridine and kynurenine pathway metabolites increase when immune activation is observed and are employed to monitor several diseases and determine prognosis. AIMS: To evaluate we aimed to elucidate the effects of immune activation on the pathophysiology of Fabry disease and to investigate the potential utility of pteridine and kynurenine metabolites...
January 22, 2024: Balkan Medical Journal
https://read.qxmd.com/read/38234283/characteristic-profiling-of-soluble-factors-in-the-cerebrospinal-fluid-of-patients-with-neurosyphilis
#25
JOURNAL ARTICLE
Dongmei Xu, Yu Jiang, Wenhui Lun, Yu Cao, Xiaoxue Xu, Beibei Wang, Rui Li, Chen Chen, Yuming Huang, Hui Zeng
BACKGROUND: Soluble inflammatory factors have been investigated in the cerebrospinal fluid (CSF) of neurosyphilis patients with low-throughput technology. This study aimed to illustrate the characteristics of soluble factors profiles in CSF of neurosyphilis patients. METHODS: We measured the concentrations of 45 cytokines/chemokines/growth factors in CSF from 112 untreated syphilis cases, including latent syphilis (LS), asymptomatic neurosyphilis (ANS), meningeal neurosyphilis (MNS), meningovascular neurosyphilis (MVNS), paralytic dementia (PD) and ocular syphilis (OS)...
January 17, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38112358/respiratory-microbiome-and-its-relationship-with-inflammatory-markers
#26
JOURNAL ARTICLE
Olesya M Horlenko, Iryna Yu Pikina, Lyubomyra B Prylypko, Gabriella B Kossey, Maria A Derbak, Adrian I Tomey, Volodymyr Yu Mashyka
OBJECTIVE: The aim: This study aims to investigate and analyze the microbiome of the nasopharyngeal zone in acute respiratory infections (ARI) and their relationship with inflammatory markers. PATIENTS AND METHODS: Materials and methods: Examination of 112 children (10-14 years old) with acute respiratory infections (ARI) of the upper respiratory tract was carried out. The control group consisted of 25 healthy children identical in age and examination parameters...
2023: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://read.qxmd.com/read/38059529/distinct-effects-of-ssris-and-snris-on-soluble-biomarkers-in-blood-and-cerebrospinal-fluid-of-people-with-hiv
#27
JOURNAL ARTICLE
Mattia Trunfio, Bin Tang, Jennifer E Iudicello, Qing Ma, Donald R Franklin, Debra Cookson, Patricia K Riggs, Mariana Cherner, David J Moore, Robert K Heaton, Scott L Letendre, Ronald J Ellis
BACKGROUND: Persistent inflammation affects people with HIV (PWH) despite antiretroviral therapy (ART). Selective serotonin and serotonin-norepinephrine reuptake inhibitors (SSRIs, SNRIs), HMG-CoA reductase-inhibitors (statins), and angiotensin-converting enzyme inhibitors (ACEIs) have immuno-modulant properties. We evaluated the potential impact of these drugs on inflammation and neurodegeneration in PWH. METHODS: Cross-sectional single-center (U.S.) analysis in 184 PWH on ART with plasma HIV RNA < 200 cp/mL...
December 6, 2023: Journal of Infectious Diseases
https://read.qxmd.com/read/38058222/the-emerging-role-of-growth-differentiation-factor-15-as-a-potential-disease-biomarker-in-juvenile-dermatomyositis
#28
JOURNAL ARTICLE
Bhargavi Duvvuri, Jorge A Gonzalez-Chapa, Lauren M Pachman, Gabrielle A Morgan, Nidhi Naik, Susan Shenoi, Christian Lood
OBJECTIVE: We aimed to investigate the potential of Growth Differentiation Factor 15 (GDF-15) as a novel biomarker for disease activity in Juvenile Dermatomyositis (JDM). METHODS: We recruited children with juvenile myositis including juvenile dermatomyositis (n = 77), polymyositis (n = 6), and healthy controls (n = 22). GDF-15 levels in plasma were measured using ELISA. Statistical analyses were performed using non-parametric tests...
December 7, 2023: Rheumatology
https://read.qxmd.com/read/38031497/verification-studies-of-tryptophan-and-kynurenine-determination-using-hplc-and-evaluation-of-the-kynurenine-pathway-and-neopterin-levels-in-human-colostrum-samples
#29
JOURNAL ARTICLE
Gozde Girgin, Sonia Sanajou, Sinem Meric-Deliveli, Terken Baydar
Colostrum, the first breast fluid produced by mammals after giving birth, is followed by breast milk, which serves as the sole source of nutrients for breastfed newborns and infants. Tryptophan, an essential amino acid, plays a crucial role in the development and maturation of the central nervous system in infants. Tryptophan is primarily degraded through the kynurenine pathway. Owing to its sensitivity to dietary intake, immune-mediated tryptophan degradation is assessed by the kynurenine-to-tryptophan ratio, with a focus on one of the rate-limiting enzymes in the pathway...
November 29, 2023: Biomedical Chromatography: BMC
https://read.qxmd.com/read/38023738/the-relationship-between-balance-and-urinary-cortisol-and-neopterin-in-autistic-children
#30
JOURNAL ARTICLE
Siobhan de Lange, Dee Muller, Chloe Dafkin
Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by stereotyped behavior, restricted interests and social/communicative deficits. The physiological etiology of ASD is not currently understood, however recent research has implicated dysregulation of the immune system as a central feature. The interplay between the stress systems, the immune system and the brain has been well-documented and implicated in other psychiatric and neurological disorders. This interplay suggests a role for the hypothalamic-pituitary-adrenal (HPA) axis in the etiology of ASD...
November 2023: Comprehensive psychoneuroendocrinology
https://read.qxmd.com/read/37968601/epstein-barr-virus-reactivation-is-not-causative-for-post-covid-19-syndrome-in-individuals-with-asymptomatic-or-mild-sars-cov-2-disease-course
#31
JOURNAL ARTICLE
Alexandra Domnica Hoeggerl, Verena Nunhofer, Wanda Lauth, Natalie Badstuber, Nina Held, Georg Zimmermann, Christoph Grabmer, Lisa Weidner, Christof Jungbauer, Nadja Lindlbauer, Heidrun Neureiter, Tuulia Ortner, Maria Flamm, Jürgen Osterbrink, Eva Rohde, Sandra Laner-Plamberger
PURPOSE: Post-COVID-19-Syndrome (PCS) frequently occurs after an infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). However, the understanding of causative mechanisms is still limited. Aim of this study was to determine the PCS rate among SARS-CoV-2 seropositive blood donors as representatives of supposedly healthy adults, who had experienced an asymptomatic or mild COVID-19 disease course, and to examine whether Epstein-Barr virus (EBV) is reactivated in individuals reporting PCS...
November 15, 2023: BMC Infectious Diseases
https://read.qxmd.com/read/37943877/emotional-states-predict-cellular-immune-system-activity-under-conditions-of-life-as-it-is-lived-a-multivariate-time-series-analysis-approach
#32
JOURNAL ARTICLE
Lennart Seizer, Dietmar Fuchs, Harald R Bliem, Christian Schubert
The relationship between emotional states and immune system activity is characterized by bidirectional influences; however, limited information is available regarding the temporal dynamics of these effects. The goal of this investigation was to examine how these psychoimmunological interdependencies unfold over time under conditions of "life as it is lived". For this purpose, three healthy women collected their entire urine over a period of approximately two months at 12-h intervals (8 am-8 pm, 8 pm-8 am), resulting in a total of 112 to 126 consecutive measurements per subject...
2023: PloS One
https://read.qxmd.com/read/37937220/serum-interleukin-6-procalcitonin-and-c-reactive-protein-at-hospital-admission-can-identify-patients-at-low-risk-for-severe-covid-19-progression
#33
JOURNAL ARTICLE
Christian Matthias Zobel, Werner Wenzel, Jan Philipp Krüger, Ulrich Baumgarten, Tobias Wagelöhner, Nino Neumann, Behruz Foroutan, Rico Müller, Annette Müller, Dominic Rauschning, Meike Schüßler, Lorenz Scheit, Felix Weinreich, Klaas Oltmanns, Franziska Keidel, Maria Koch, Sebastian Spethmann, Maximilian Schreiner
BACKGROUND: COVID-19 can show a variable course, from asymptomatic infections to acute respiratory failure and death. For efficient allocation of resources, patients should be stratified according to their risk for a severe course as early as possible. METHODS: 135 hospitalized patients with COVID-19 pneumonia at four German hospitals were prospectively included in this observational study. A standardized clinical laboratory profile was taken at hospital admission and a panel of serum markers with possible roles in the COVID-associated cytokine storm were also determined...
2023: Frontiers in Microbiology
https://read.qxmd.com/read/37906406/changes-in-cerebrospinal-fluid-liver-and-intima-media-thickness-biomarkers-in-patients-with-hiv-associated-neurocognitive-disorders-randomized-to-a-less-neurotoxic-treatment-regimen
#34
RANDOMIZED CONTROLLED TRIAL
Giacomo Stroffolini, Alessandro Lazzaro, Ambra Barco, Veronica Pirriatore, Daniela Vai, Claudia Giaccone, Marco Nigra, Cristiana Atzori, Mattia Trunfio, Stefano Bonora, Giovanni Di Perri G, Andrea Calcagno
The prevalence of neurocognitive impairment in people living with HIV is estimated between 30 and 50%. The pathogenesis of HIV-associated neurocognitive disorders is complex and multifactorial. Aim of the study was to measure the change in CSF biomarkers, Fibroscan and IMT measurements in PLWH with HAND randomized to a less neurotoxic regimen, or continuing their treatment. Adult patients with HAND were screened and enrolled if presenting no major resistance associated mutations, no HIV viral replication, not on efavirenz or darunavir, with R5-tropic HIV and without major confounding conditions...
December 2023: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/37882748/biological-variation-of-serum-neopterin-concentrations-in-apparently-healthy-individuals
#35
JOURNAL ARTICLE
Yakup Dülgeroğlu, Müjgan Ercan
OBJECTIVES: The aims of this study were to determine the biological variation (BV), reference change value (RCV), index of individuality (II), and quality specifications for serum neopterin concentrations; a measurand provided by clinical laboratories as an indicator of cellular immunity. METHODS: The study delivered serum samples collected for 10 consecutive weeks from 12 apparently healthy individuals (3 male, 9 female). Serum neopterin concentrations were measured using high-performance liquid chromatography with fluorometric detection...
October 26, 2023: Clinical Chemistry and Laboratory Medicine: CCLM
https://read.qxmd.com/read/37874918/covid-19-recovery-consistent-absence-of-cerebrospinal-fluid-biomarker-abnormalities-in-patients-with-neurocognitive-post-covid-complications
#36
JOURNAL ARTICLE
Nelly Kanberg, Anna Grahn, Erika Stentoft, Daniel Bremell, Aylin Yilmaz, Marie Studahl, Staffan Nilsson, Michael Schöll, Johanna M Gostner, Kaj Blennow, Henrik Zetterberg, Nikhil Padmanabhan, Rachel Cohen, Salvia Misaghian, Daniel Romero, Christopher Campbell, Anu Mathew, Mingyue Wang, George Sigal, Martin Stengelin, Arvid Edén, Magnus Gisslén
BACKGROUND: To investigate evidence of residual viral infection, intrathecal immune activation, central nervous system (CNS) injury, and humoral responses in cerebrospinal fluid (CSF) and plasma in patients recovering from coronavirus disease 2019 (COVID-19), with or without neurocognitive post-COVID condition (PCC). METHODS: Thirty-one participants (25 with neurocognitive PCC) underwent clinical examination, lumbar puncture, and venipuncture ≥3 months after COVID-19 symptom onset...
October 24, 2023: Journal of Infectious Diseases
https://read.qxmd.com/read/37866678/quantification-of-enteric-dysfunction-in-cystic-fibrosis-inter-and-intra-individual-variability
#37
JOURNAL ARTICLE
Laura A Duckworth, Kimberly A Sutton, Nurmohammad Shaikh, Jinli Wang, Carla Hall-Moore, Lori R Holtz, Phillip I Tarr, Ronald C Rubenstein
OBJECTIVES: To test the utility of various biomarkers as indicators of gut dysfunction in cystic fibrosis (CF) and determine whether intra-individual variations in these measures are repeatable over short intervals and whether inter-individual variations correlate with clinical outcomes. STUDY DESIGN: We performed a cross-sectional, limited longitudinal study of children with CF aged 1-21 years who provided blood and stool samples at 2 or 3 visits, 2 weeks and 3 months apart, which were assayed for markers of intestinal inflammation (fecal calprotectin [fCal], lipocalin-2 [fLcn2], neopterin [fNeo]) and permeability (plasma lipopolysaccharide [LPS] antibodies, LPS-binding protein) by enzyme immunoassays...
October 20, 2023: Journal of Pediatrics
https://read.qxmd.com/read/37828673/neopterin-as-a-potential-biomarker-for-the-early-diagnosis-of-heart-failure-a-systematic-review-and-meta-analysis
#38
JOURNAL ARTICLE
Golnaz Mahmoudvand, Arian Karimi Rouzbahani, Ali Kheirandish, Amene Saghazadeh, Nima Rezaei
BACKGROUND: Neopterin (NEO) is an inflammatory biomarker with proposed diagnostic value in cardiovascular diseases. Some correlations have been discovered between NEO levels and the incidence, severity, and adverse outcomes of heart failure (HF). However, there are discrepancies in the results reported in the literature. METHODS: We conducted a systematic review and meta-analysis of studies comparing urinary and blood NEO concentrations between individuals with HF, cardiac insufficiency, or dilated cardiomyopathy (DCM) with control groups or those monitoring the role of NEO concentrations as a predictive marker of adverse outcomes in HF patients...
October 11, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37819145/association-of-intestinal-bacteria-with-immune-activation-in-a-cohort-of-healthy-adults
#39
JOURNAL ARTICLE
Niknaz Riazati, Mary E Kable, Charles B Stephensen
Interactions among intestinal bacteria and the immune system contribute to the maintenance of a functional intestinal barrier in healthy individuals, and possibly to systemic immune activity. We hypothesized that intestinal bacteria would be associated with systemic biomarkers of innate and adaptive immune responses in healthy adults. 79 immune function markers were subjected to factor analysis resulting in 17 Immune Factors (IFs), each composed of 2-10 immune variables. Bacterial taxa from stool samples were identified at the family and genus levels by 16S rRNA amplicon sequence analysis and their read counts and relative abundances were utilized in a multiple linear regression model to identify microbial taxa associated with the IFs...
October 11, 2023: Microbiology Spectrum
https://read.qxmd.com/read/37799718/a-systematic-review-and-meta-analysis-of-neopterin-in-rheumatic-diseases
#40
Arduino A Mangoni, Angelo Zinellu
INTRODUCTION: Novel biomarkers of inflammation and oxidative stress might enhance the early recognition, management, and clinical outcomes of patients with rheumatic diseases (RDs). We assessed the available evidence regarding the pathophysiological role of neopterin, the oxidation product of 7,8-dihydroneopterin, a pteridine generated in macrophages activated by interferon-γ, by conducting a systematic review and meta-analysis of studies reporting its concentrations in biological fluids in RD patients and healthy controls...
2023: Frontiers in Immunology
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