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Neopterin

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https://www.readbyqxmd.com/read/27894401/association-between-the-cytotoxic-t-lymphocyte-antigen-4-mutations-and-the-susceptibility-to-systemic-lupus-erythematosus-contribution-markers-of-inflammation-and-oxidative-stress
#1
M Tanhapour, A Vaisi-Raygani, F Bahrehmand, M Khazaei, A Kiani, Z Rahimi, H Nomani, H Tavilani, T Pourmotabbed
: The cytotoxic T lymphocyte antigen-4 (CTLA-4) also known as CD152 (cluster of differentiation 152) is a crucial negative regulator of the immune system. This protein receptor provides negative signals in order to suppress T-cell activation and immune attack against self-antigens, although its role is unclear.  The ability of CTLA-4 to limit T cell-mediated immune response has made it a major target in treatment of tumors and autoimmune diseases such as systemic lupus erythematosus (SLE)...
October 31, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27886064/probiotic-supplements-beneficially-affect-tryptophan-kynurenine-metabolism-and-reduce-the-incidence-of-upper-respiratory-tract-infections-in-trained-athletes-a-randomized-double-blinded-placebo-controlled-trial
#2
Barbara Strasser, Daniela Geiger, Markus Schauer, Johanna M Gostner, Hannes Gatterer, Martin Burtscher, Dietmar Fuchs
BACKGROUND: Prolonged intense exercise has been associated with transient suppression of immune function and an increased risk of infections. In this context, the catabolism of amino acid tryptophan via kynurenine may play an important role. The present study examined the effect of a probiotic supplement on the incidence of upper respiratory tract infections (URTI) and the metabolism of aromatic amino acids after exhaustive aerobic exercise in trained athletes during three months of winter training...
November 23, 2016: Nutrients
https://www.readbyqxmd.com/read/27882497/soluble-tlr2-and-4-concentrations-in-cerebrospinal-fluid-in-hiv-siv-related-neuropathological-conditions
#3
Khutso M Mothapo, J Ten Oever, P Koopmans, F F Stelma, S Burm, J Bajramovic, M M Verbeek, M G Olde Rikkert, M G Netea, G Koopman, A J van der Ven
HIV in the central nervous system (CNS) mainly infects microglial cells which are known to express toll-like receptors (TLRs). This paper aimed to study the role of soluble TLR2 (sTLR2), sTLR4, and other inflammatory markers in cerebrospinal fluid (CSF) in HIV/Simian immunodeficiency virus (SIV)-related neurological sequelae. We determined sTLR2 and sTLR4 levels in CSF and serum/plasma of SIV-infected rhesus macaques with and without neurological sequelae, as well as in HIV-infected patients with and without cognitive impairments and Alzheimer's disease (AD) patients and matched controls...
November 23, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27879161/neopterin-and-oxidative-stress-markers-in-the-diagnosis-of-extrapulmonary-tuberculosis
#4
Nisha Goyal, Bineeta Kashyap, N P Singh, Iqbal R Kaur
BACKGROUND: Extrapulmonary tuberculosis (EPTB) often presents with non-specific signs and symptoms. Further the paucibacillary nature of extrapulmonary specimens and irregular distribution of bacilli lower the sensitivity of conventional diagnostic methods making EPTB, a diagnostic dilemma. Objective To study neopterin, protein carbonyl and malondialdehyde in extrapulmonary tuberculosis. METHODS: 69 clinically confirmed cases with an equal number of age and sex matched healthy controls were enrolled...
November 23, 2016: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/27876593/intact-interferon-%C3%AE-response-against-coxiella-burnetii-by-peripheral-blood-mononuclear-cells-in-chronic-q-fever
#5
Teske Schoffelen, Julien Textoris, Chantal P Bleeker-Rovers, Amira Ben Amara, Jos W M van der Meer, Mihai G Netea, Jean-Louis Mege, Marcel van Deuren, Esther van de Vosse
OBJECTIVES: Q fever is caused by Coxiella burnetii, an intracellular bacterium that infects phagocytes. The aim of the present study was to investigate whether the C. burnetii-induced IFN-γ response is defective in chronic Q fever patients. METHODS: IFN-γ was measured in supernatants of C. burnetii-stimulated peripheral blood mononuclear cells (PBMCs) of 17 chronic Q fever patients and 17 healthy individuals. To assess IFN-γ responses, expression profiles of IFN-γ-induced genes in C...
November 19, 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27868081/blood-brain-barrier-integrity-intrathecal-immunoactivation-and-neuronal-injury-in-hiv
#6
Birgitta Anesten, Aylin Yilmaz, Lars Hagberg, Henrik Zetterberg, Staffan Nilsson, Bruce J Brew, Dietmar Fuchs, Richard W Price, Magnus Gisslén
OBJECTIVE: Although blood-brain barrier (BBB) impairment has been reported in HIV-infected individuals, characterization of this impairment has not been clearly defined. METHODS: BBB integrity was measured by CSF/plasma albumin ratio in this cross-sectional study of 631 HIV-infected individuals and 71 controls. We also analyzed CSF and blood HIV RNA and neopterin, CSF leukocyte count, and neurofilament light chain protein (NFL) concentrations. The HIV-infected participants included untreated neuroasymptomatic patients, patients with untreated HIV-associated dementia (HAD), and participants on suppressive antiretroviral treatment (ART)...
December 2016: Neurology® Neuroimmunology & Neuroinflammation
https://www.readbyqxmd.com/read/27861525/elevated-neopterin-levels-are-associated-with-increased-tuberculosis-risk-in-rheumatoid-arthritis-patients-with-quantiferon-conversion-during-biologic-therapy
#7
Der-Yuan Chen, Ju-Pi Li, Yi-Ming Chen, Tsai-Ling Liao, Hsin-Hua Chen, Chia-Wei Hsieh, Yea-Wen Yeh, Joung-Liang Lan
QuantiFERON-TB-Gold (QFT-G) conversion is frequently observed in rheumatoid arthritis (RA) patients receiving biologic therapy. However, there have not been any known biomarkers available for detecting tuberculosis (TB) in QFT-G converters. We aimed to evaluate clinical utility of cytokines/chemokines for detecting TB in patients with QFT-G conversion. Among a total of 227 RA patients who underwent QFT-G assay, 187 QFT-G-negative patients received biologic therapy without isoniazid prophylaxis. QFT-G assay was repeated at week 52 of biologic therapy or at the time of TB diagnosis...
2016: PloS One
https://www.readbyqxmd.com/read/27851899/cognitive-ability-in-down-syndrome-and-its-relationship-to-urinary-neopterin-a-marker-of-activated-cellular-immunity
#8
Panagiotis Zis, André Strydom, David Buckley, Daniel Adekitan, Patrick C McHugh
BACKGROUND: Neopterin is an unconjugated pteridine that is secreted in large quantities by activated macrophages and can be used as a clinical marker of activated cellular immunity and oxidative stress. We aimed to investigate whether urinary neopterin levels are associated with cognitive function in people with Down syndrome (DS). METHODS: Out of 32 adults with DS who originally participated in a longitudinal study, 25 were followed up at 4 years. Informants rated their adaptive behavior (ABAS) and the adults with DS attempted assessments of language skills and memory at both baseline and follow-up time points (Modified Memory Object Task, MOMT), and receptive vocabulary (British Picture Vocabulary Scale, BPVS)...
November 13, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27845163/the-effect-of-htlv-1-virulence-factors-hbz-tax-proviral-load-hla-class-i-and-plasma-neopterin-on-manifestation-of-htlv-1-associated-myelopathy-tropical-spastic-paraparesis
#9
Hanieh Tarokhian, Mahdi Taghadosi, Hushang Rafatpanah, Taraneh Rajaei, Mahmoud Reza Azarpazhooh, Narges Valizadeh, S A Rahim Rezaee
BACKGROUND: Previous studies have suggested debatable roles of Tax and HBZ gene expression in the pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this study, HTLV-1 and host interactions in the manifestation of HAM/TSP were evaluated. METHODS: A cross-sectional study was conducted on 33 HAM/TSP patients and 38 HTLV-1 asymptomatic carriers (ACs). HTLV-1-Tax, HBZ gene expression, and proviral load (PVL) were assessed using the quantitative real-time PCR (TaqMan), host plasma neopterin level, and HLA-I, and the clinical manifestation were evaluated...
November 12, 2016: Virus Research
https://www.readbyqxmd.com/read/27832762/tryptophan-metabolism-its-relation-to-inflammation-and-stress-markers-and-association-with-psychological-and-cognitive-functioning-tasmanian-chronic-kidney-disease-pilot-study
#10
Naama Karu, Charlotte McKercher, David S Nichols, Noel Davies, Robert A Shellie, Emily F Hilder, Matthew D Jose
BACKGROUND: Adults with chronic kidney disease (CKD) exhibit alterations in tryptophan metabolism, mainly via the kynurenine pathway, due to higher enzymatic activity induced mainly by inflammation. Indoles produced by gut-microflora are another group of tryptophan metabolites related to inflammation and conditions accompanying CKD. Disruptions in tryptophan metabolism have been associated with various neurological and psychological disorders. A high proportion of CKD patients self-report symptoms of depression and/or anxiety and decline in cognitive functioning...
November 10, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27826896/blood-brain-barrier-impairment-in-hiv-positive-na%C3%A3-ve-and-effectively-treated-patients-immune-activation-versus-astrocytosis
#11
A Calcagno, A Romito, C Atzori, V Ghisetti, C Cardellino, S Audagnotto, E Scarvaglieri, F Lipani, D Imperiale, G Di Perri, S Bonora
Blood brain barrier (BBB) damage is a common feature in central nervous system infections by HIV and it may persist despite effective antiretroviral therapy. Astrocyte involvement has not been studied in this setting. Patients were enrolled in an ongoing prospective study and subjects with central nervous system-affecting disorders were excluded. Patients were divided into two groups: treated subjects with cerebrospinal fluid (CSF) HIV RNA <50 copies/mL (CSF-controllers) and in late-presenters CD4+ T lymphocytes <100/uL...
November 8, 2016: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://www.readbyqxmd.com/read/27819802/immediate-initiation-of-cart-is-associated-with-lower-levels-of-cerebrospinal-fluid-ykl-40-a-marker-of-microglial-activation-in-hiv-1-infection
#12
Michael J Peluso, Victor Valcour, Nittaya Phanuphak, Jintanat Ananworanich, James Lk Fletcsher, Thep Chalermchai, Shelly J Krebs, Merlin L Robb, Joanna Hellmuth, Magnus Gisslén, Henrik Zetterberg, Serena Spudich
OBJECTIVE: To characterize cerebrospinal fluid (CSF) YKL-40, a unique biomarker that reflects activation of microglial cells, in acute (AHI) and chronic HIV-1 infection (CHI) and to determine the effect of treatment initiation on levels of this marker. DESIGN: Cross-sectional study of two groups of HIV-infected participants at baseline and follow-up timepoints. METHODS: AHI (n = 33) and CHI (n = 34) participants underwent CSF and blood sampling before treatment initiation with combination antiretroviral therapy (cART) and at follow up on cART in a subset of these individuals (6 months in AHI participants [n = 24], 1 year in CHI participants [n = 10])...
November 2, 2016: AIDS
https://www.readbyqxmd.com/read/27812290/tryptophan-metabolism-and-its-relationship-with-depression-and-cognitive-impairment-among-hiv-infected-individuals
#13
Michael R Keegan, Seetharamaiah Chittiprol, Scott L Letendre, Alan Winston, Dietmar Fuchs, Adriano Boasso, Jennifer Iudicello, Ronald J Ellis
OBJECTIVE: Cognitive impairment (CI) and major depressive disorder (MDD) remain prevalent in treated HIV-1 disease; however, the pathogenesis remains elusive. A possible contributing mechanism is immune-mediated degradation of tryptophan (TRP) via the kynurenine (KYN) pathway, resulting in decreased production of serotonin and accumulation of TRP degradation products. We explored the association of these biochemical pathways and their relationship with CI and MDD in HIV-positive (HIV+) individuals...
2016: International Journal of Tryptophan Research: IJTR
https://www.readbyqxmd.com/read/27801365/oxidative-stress-parameters-and-inflammatory-and-immune-mediators-as-markers-of-the-severity-of-sepsis
#14
Isil Bavunoglu, Habibe Genc, Dildar Konukoglu, Hayriye Cicekci, Volkan Sozer, Remise Gelisgen, Hafize Uzun
INTRODUCTION: Sepsis is a complex inflammatory syndrome with diverse etiology and wide spectrum of severity. The aim of this study was to investigate whether inflammatory mediators, in comparison with oxidative parameters, are associated with severity of sepsis. METHODOLOGY: Plasma neopterin, adenosine deaminase (ADA), vascular cell adhesion molecule (VCAM), intracellular adhesion molecule (ICAM), interleukin (IL)-1, IL-6, and tumor necrosis factor alpha (TNF-α), as inflammatory mediators, and serum nitric oxide (NOx), nitrotyrosine (NT), oxidized LDL (oxLDL) levels, serum paraoxonase 1 (PON1) activity, and erythrocyte glutathione (GSH) levels as oxidative stress parameters of 12 patients with mild sepsis, 25 patients with severe sepsis, and 20 healthy control subjects were evaluated...
October 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27774267/the-clinical-significance-of-plasma-neopterin-in-heart-failure-with-preserved-left-ventricular-ejection-fraction
#15
Eiichiro Yamamoto, Yoshihiro Hirata, Takanori Tokitsu, Hiroaki Kusaka, Noriaki Tabata, Kenichi Tsujita, Megumi Yamamuro, Koichi Kaikita, Hiroshi Watanabe, Seiji Hokimoto, Toru Maruyama, Hisao Ogawa
AIMS: Although inflammation plays an important role in the pathogenesis of heart failure (HF), the precise pathophysiological role of inflammation in HF with preserved left ventricular ejection fraction (HFpEF) still remains unclear. Hence, we examined the clinical significance of plasma neopterin, an inflammatory biomarker, in HFpEF patients. METHODS AND RESULTS: In the present study, we recruited consecutive HFpEF patients hospitalized in Kumamoto University Hospital, and further measured plasma neopterin by high-performance liquid chromatography and serum derivatives of reactive oxidative metabolites (DROM), a new biomarker of reactive oxygen species...
March 2016: ESC Heart Failure
https://www.readbyqxmd.com/read/27772753/antioxidant-and-inflammatory-biomarkers-for-the-identification-of-prodromal-parkinson-s-disease
#16
Jonica Campolo, Renata De Maria, Lorena Cozzi, Marina Parolini, Stefano Bernardi, Paola Proserpio, Lino Nobili, Giorgio Gelosa, Immacolata Piccolo, Elio C Agostoni, Maria G Trivella, Paolo Marraccini
OBJECTIVES: We explored the role of oxidative stress and inflammatory molecules as potential Parkinson (PD) biomarkers and correlated biological with non-motor abnormalities (olfactory impairment and dysautonomia), in patients with idiopathic REM behavior disorder (iRBD) (prodromal PD) and established PD. METHODS: We recruited 11 iRBD and 15 patients with idiopathic PD (Hohen&Yahr 1-3, on L-DOPA and dopamine agonists combination therapy) and 12 age- and sex-matched controls (CTRL)...
November 15, 2016: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/27699655/serum-level-of-neopterin-is-not-a-marker-of-disease-activity-in-treated-rheumatoid-arthritis-patients
#17
Dalia El-Lebedy, Jihan Hussein, Ingy Ashmawy, Asmaa M Mohammed
Neopterin has been measured in many autoimmune diseases and was reported as a marker of cellular immunity activation in rheumatoid asthritis (RA). The aim of this work was to assess serum neopterin as a marker of disease activity in treated RA patients. We measured serum level of neopterin in 120 treated RA patients and 100 age- and sex-matched controls by high-performance liquid chromatography (HPLC) method, and disease activity score was calculated in all patients by DAS28-CRP score. Significantly higher levels of neopterin were observed in RA patients (11...
October 3, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27693318/accuracies-of-fecal-calprotectin-lactoferrin-m2-pyruvate-kinase-neopterin-and-zonulin-to-predict-the-response-to-infliximab-in-ulcerative-colitis
#18
Anne-Claire Frin, Jérôme Filippi, Gilles Boschetti, Bernard Flourie, Jocelyne Drai, Patricia Ferrari, Xavier Hebuterne, Stéphane Nancey
BACKGROUND: Fecal markers might predict the response to anti-TNFα in ulcerative colitis (UC). AIMS: To compare the performance of fecal calprotectin (fCal), lactoferrin (fLact), M2-PK (fM2-PK), neopterin (fNeo), and zonulin (fZon) to predict the response to therapy in active UC patients. METHODS: Disease activity from 31 consecutive patients with an active UC, treated with infliximab (IFX) was assessed by the Mayo score at baseline and at week 14 and by the partial Mayo score at W52 and stool samples collected for fecal marker measurements at W0, W2, and W14...
September 13, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27690418/effect-of-coffee-in-lipopolysaccharide-induced-indoleamine-2-3-dioxygenase-activation-and-depressive-like-behaviour-in-mice
#19
Susan Hall, Devinder Arora, Shailendra Anoopkumar-Dukie, Gary D Grant
Research has identified a potential inverse-correlation between coffee consumption and the risk of depression. The aim of this study was to investigate the effects of caffeinated coffee on lipopolysaccharide-induced depressive-like behaviours and inflammatory biomarkers in an in vivo model of depression in a C57BL/6J mouse model. The behavioural studies showed both caffeinated coffee to decrease immobility time in the tail suspension test (56.60 ± 9.17; p < 0.0001) and the forced swimming test (caffeinated coffee 28...
October 3, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27690129/biomarkers-of-environmental-enteropathy-inflammation-stunting-and-impaired-growth-in-children-in-northeast-brazil
#20
Richard L Guerrant, Alvaro M Leite, Relana Pinkerton, Pedro H Q S Medeiros, Paloma A Cavalcante, Mark DeBoer, Margaret Kosek, Christopher Duggan, Andrew Gewirtz, Jonathan C Kagan, Anna E Gauthier, Jonathan Swann, Jordi Mayneris-Perxachs, David T Bolick, Elizabeth A Maier, Marjorie M Guedes, Sean R Moore, William A Petri, Alexandre Havt, Ila F Lima, Mara de Moura Gondim Prata, Josyf C Michaleckyj, Rebecca J Scharf, Craig Sturgeon, Alessio Fasano, Aldo A M Lima
Critical to the design and assessment of interventions for enteropathy and its developmental consequences in children living in impoverished conditions are non-invasive biomarkers that can detect intestinal damage and predict its effects on growth and development. We therefore assessed fecal, urinary and systemic biomarkers of enteropathy and growth predictors in 375 6-26 month-old children with varying degrees of malnutrition (stunting or wasting) in Northeast Brazil. 301 of these children returned for followup anthropometry after 2-6m...
2016: PloS One
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