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Acute pancreatitis, ROC

Sheng-Huei Wang, Yu-Ching Chou, Wei-Chuan Shangkuan, Kuang-Yu Wei, Yu-Han Pan, Hung-Che Lin
BACKGROUND: Hypertriglyceridemia is the third most common cause of acute pancreatitis, but whether the level of triglyceride (TG) is related to severity of pancreatitis is unclear. AIM: To evaluate the effect of TG level on the severity of hypertriglyceridemic pancreatitis (HTGP). DESIGN: Retrospective cohort study. METHODS: We reviewed the records of 144 patients with HTGP from 1999 to 2013 at Tri-Service General Hospital...
2016: PloS One
Yu-Ping Zhang, Chang Liu, Lei Ye, Na Yu, Yuan-Ning Ye, Wen-Rong Sun, Lin Wu, Fang-Yu Wang
BACKGROUND: Biomarkers for the early prediction of the severity of acute pancreatitis (AP) are urgently needed for clinical management of the disease. Angiopoietin-2 (Ang-2), one of the autocrine peptides that reduce endothelial permeability, has been found to be associated with various diseases, including inflammatory disorders. AIMS: This study aimed to determine whether serum Ang-2 could serve as a noninvasive biomarker for the early prediction of persistent organ failure (POF) in acute pancreatitis...
September 29, 2016: Digestive Diseases and Sciences
Liang Ji, Jia-Chen Lv, Zeng-Fu Song, Mai-Tao Jiang, Le Li, Bei Sun
BACKGROUND: Severe acute pancreatitis (SAP) remains a clinical challenge with considerable morbidity and mortality. An early identification of infected pancreatic necrosis (IPN), a life-threatening evolution secondary to SAP, is obliged for a more preferable prognosis. Thus, the present study was conducted to identify the risk factors of IPN secondary to SAP. METHODS: The clinical data of patients with SAP were retrospectively analyzed. Univariate and multivariate logistic regression analyses were sequentially performed to assess the associations between the variables and the development of IPN secondary to SAP...
August 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
Feng Kai, Liu Lifeng, Song Haijing, Liu Xianhua, Xia Hu
OBJECTIVE: To investigate the predictive value of 4,183 Da peptide of dermcidin protein in the early diagnosis and differential diagnosis of ischemic heart disease. METHODS: A prospective controlled study was conducted. Serum samples were drawn from 161 patients with acute coronary'syndrome [ACS, including 46 patients with unstable angina (UA), 23 with acute non-ST elevation myocardial infarction, and 92 with acute ST segment elevation myocardial infarction], 111 subjects for routine physical examination, including 45 patients with hypertension history, 42 with coronary heart disease, 22 with diabetes, and 54 patients with non-ACS (including pulmonary embolism, aortic dissection, aneurysm, arrhythmia, myocarditis, coronary myocardial bridge, pleurisy, pneumothorax pneumomediastinum, rib fracture, reflux esophagitis, peptic ulcer, and pancreatitis) to serve as controls...
December 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Bohyun Kim, Seung Soo Lee, Yu Sub Sung, Hyunhee Cheong, Jae Ho Byun, Hyoung Jung Kim, Jin Hee Kim
PURPOSE: To evaluate the diagnostic value of apparent diffusion coefficient (ADC) and intravoxel incoherent motion (IVIM) parameters in differentiating patients with either a normal pancreas (NP), pancreatic ductal adenocarcinoma (PDAC), neuroendocrine tumor (NET), solid pseudopapillary tumor (SPT), acute pancreatitis (AcP), vs. autoimmune pancreatitis (AIP). MATERIALS AND METHODS: In all, 84 pathologically confirmed pancreatic tumors (60 PDACs, 15 NETs, 9 SPTs), 20 pancreatitis (13 AcPs, 7 AIPs), and 30 NP subjects underwent IVIM diffusion-weighted imaging using 10 b-values (0-900 sec/mm(2) ) at 1...
June 7, 2016: Journal of Magnetic Resonance Imaging: JMRI
Bing Zhao, Ying Chen, Wen Wu Sun, Wei Wei Chen, Li Ma, Zhi Tao Yang, Jun Huang, Er Zhen Chen, Jian Fei, En Qiang Mao
OBJECTIVE: To assess whether serum levels of S100A12 and soluble receptor for advanced glycation end products (sRAGE) could predict the severity of acute pancreatitis (AP). METHODS: We conducted a non-interventional pilot study, including 74 AP patients and 28 healthy volunteers serving as controls. AP patients were further divided into the mild (MAP, n = 22), moderately severe (MSAP, n = 30) and severe (SAP, n = 22) groups. Peripheral blood samples were collected within 72 h after the onset of AP for the determination of S100A12, sRAGE and C-reactive protein (CRP) levels...
July 2016: Journal of Digestive Diseases
Dan-ping Qin, Xia Wei, Guo-dong Fang, Feng Yang, Deng-pan Lai
OBJECTIVE: To study the effect of Modified Dachengqi Decoction (MDD) as whole course therapy on mediators of inflammation in severe acute pancreatitis (SAP) model rats, and to compare interventional advantages over intestinal mucosal barrier (IMB) of SAP rats between whole course therapy of MDD and early stage therapy of MDD. METHODS: Totally 190 SD rats were divided into five groups according to random digit table, i.e., the sham-operation group, the model group, the octreotide (OT) group, the early stage MDD treatment group, the whole course MDD treatment group, 38 in each group...
December 2015: Chinese Journal of Integrated Traditional and Western Medicine
S S Bansal, J Hodson, R S Sutcliffe, R Marudanayagam, P Muiesan, D F Mirza, J Isaac, K J Roberts
BACKGROUND: Severity classification systems aim to stratify patients with acute pancreatitis reliably into coherent risk groups. Recently, the Atlanta 1992 classification has been revised (Atlanta 2012) and a novel determinant-based classification (DBC) system developed. This study assessed the ability of the three systems to stratify disease severity among patients with acute pancreatitis. METHODS: This was an observational cohort study of patients with acute pancreatitis identified from an institutional database...
March 2016: British Journal of Surgery
N O Zarnescu, R Costea, E C Zarnescu Vasiliu, S Neagu
UNLABELLED: Background/ Aims: Despite the existence of an easy tool to diagnose biliary tract disease as an etiology for acute pancreatitis (AP), the sensitivity of abdominal ultrasound is around 80%, which can be even lower in certain conditions. METHODOLOGY: We have retrospectively reviewed data of 146 patients admitted for acute pancreatitis between 1999 and 2013. Bivariate analysis for clinical and biochemical variables was performed with respect to etiology of AP (biliary versus non-biliary)...
October 2015: Journal of Medicine and Life
M Yuki, T Hirano, N Nagata, S Kitano, K Imataka, R Tawada, R Shimada, M Ogawa
BACKGROUND: Acute pancreatitis (AP) occurs frequently in dogs, but most previous studies examining the diagnosis of AP have used data from secondary care hospitals. HYPOTHESIS/OBJECTIVES: The aim of this study was to investigate the clinical utility of diagnostic laboratory tests in dogs with AP in a primary care hospital. ANIMALS: Sixty-four dogs with clinical signs suggestive of AP diagnosed with nonpancreatic disease (NP) or AP. METHODS: Medical records were retrospectively reviewed, including diagnostic laboratory tests considered potentially useful in the diagnosis of AP...
January 2016: Journal of Veterinary Internal Medicine
Jing Wu, Qiuhong Sun, Hua Yang
OBJECTIVE: To explore the effects of blood glucose control on glucose variability and clinical outcomes in patients with severe acute pancreatitis in intensive care unit (ICU). METHODS: A total of 72 ICU patients with severe acute pancreatitis were recruited and divided randomly into observation and control groups (n = 36 each). Both groups were treated conventionally. And the observation group achieved stable blood glucose at 6.1-8.3 mmol/L with intensive glucose control...
May 19, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
W Yue, Y Liu, W Ding, W Jiang, J Huang, J Zhang, J Liu
OBJECTIVE: Early identification of severe acute pancreatitis (SAP) progression is important in acute pancreatitis (AP) treatment. The Ranson, APACHE II and CTSI systems are difficult to use and exhibit limited predictive value. Prealbumin and fibrinogen are acute phase reactants generally used to assess the nutritional statuses and coagulation functions of AP patients, respectively. Here, we explored the value of the combination of these two markers for evaluating AP severity and prognosis...
October 2015: International Journal of Clinical Practice
Vishal Sharma, Surinder S Rana, Ravi K Sharma, Mandeep Kang, Rajesh Gupta, Deepak K Bhasin
BACKGROUND: A number of scoring systems are available to predict prognosis in acute pancreatitis (AP). The aim of the study was to compare extra-pancreatic inflammation on computed tomography (CT) (EPIC score) and renal rim sign with clinical scores (BISAP, SIRS) and conventional CT severity index (CTSI) and modified CTSI (MCTSI) in predicting persistent organ failure (POF), intervention and mortality. METHODS: The demographic, clinical and radiographic data from patients with AP were retrospectively evaluated...
July 2015: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Vishal Sharma, Surinder S Rana, Ravi K Sharma, Mandeep Kang, Rajesh Gupta, Deepak K Bhasin
BACKGROUND: A number of scoring systems are available to predict prognosis in acute pancreatitis (AP). The aim of the study was to compare extra-pancreatic inflammation on computed tomography (CT) (EPIC score) and renal rim sign with clinical scores (BISAP, SIRS) and conventional CT severity index (CTSI) and modified CTSI (MCTSI) in predicting persistent organ failure (POF), intervention and mortality. METHODS: The demographic, clinical and radiographic data from patients with AP were retrospectively evaluated...
July 2015: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
Stephanie A Lee-Felker, Ely R Felker, Barbara Kadell, James Farrell, Steven S Raman, James Sayre, David S Lu
OBJECTIVE: The purposes of this study were to identify the most common imaging features of autoimmune pancreatitis and to evaluate the utility of MDCT for differentiating autoimmune pancreatitis from two more frequently encountered differential diagnoses--pancreatic ductal adenocarcinoma and acute interstitial pancreatitis. MATERIALS AND METHODS: Dual-phase contrast-enhanced MDCT images of 91 patients (39 with autoimmune pancreatitis, 25 with pancreatic ductal adenocarcinoma, 27 with acute interstitial pancreatitis) were evaluated by two radiologists in consensus for distribution of pancreatic abnormality, sausage shape, low-attenuation halo, pancreatic duct dilatation, peripancreatic stranding, lymphadenopathy, biliary abnormality, vascular involvement, and renal lesions...
July 2015: AJR. American Journal of Roentgenology
Beata Kuśnierz-Cabala, Ewelina Nowak, Mateusz Sporek, Artur Kowalik, Marek Kuźniewski, Francisco J Enguita, Ewa Stępień
OBJECTIVES: Vascular dysfunction is a severe complication which can cause organ ischemia and damage during acute pancreatitis (AP). Laboratory assessment of AP is based on several routine parameters and does not reflect endothelial dysfunction or organ injury. Recently, small non-protein-coding RNAs (miRNAs) have been introduced to laboratory diagnostics as new biomarkers or predictive parameters. Candidate miRNAs (hsa-miR-16-5p, -103a-3p, -122-5p, -126-5p, -148a-5p, -216a-5p, -375, and -551b-5b) were selected to check their possible clinical application in stratification of patients with different AP severity...
July 2015: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
Mehmet İlhan, Gülşah İlhan, Ali Fuat Kaan Gök, Süleyman Bademler, Fatma Verit Atmaca, Cemalettin Ertekin
OBJECTIVE: Acute pancreatitis (AP) is a state of inflammation. It has been widely known that neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and red blood cell distribution width (RDW) to platelet ratio (RPR) reflect systemic inflammation. The aim of this study is to investigate whether these inflammatory markers could be used as reliable markers in early prediction of AP in pregnancy and if there is a relationship between disease severity and these markers. METHODS: The study group consisted of 14 patients, who developed AP in ongoing pregnancy, and the control group consisted of 30 healthy pregnant women...
2016: Journal of Maternal-fetal & Neonatal Medicine
Yong Hui Alvin Tan, Shumaila Rafi, Mirriam Tyebally Fang, Stephen Hwang, Ee Wen Lim, James Ngu, Su-Ming Tan
BACKGROUND: The characteristics of patients with acute pancreatitis in multi-ethnic Singapore differ from that of the populations used in formulating the modified Ranson and Glasgow scores. The use of these scoring systems has not previously been validated in the Singaporean setting. This study aims to validate and compare the prognostic use of the modified Ranson and Glasgow scores, and to determine the superiority of one score over the other in predicting the outcome for acute pancreatitis in the Singaporean population...
April 29, 2015: ANZ Journal of Surgery
Lihui Deng, Lei Wang, Fengjiao Yong, Junjie Xiong, Tao Jin, Daniel De La Iglesia-Garcia, Shameena Bharucha, Kiran Altaf, Wei Huang, Qing Xia
OBJECTIVES: The assessment of acute pancreatitis severity on admission currently remains a challenge to clinicians. A single, rapid biochemical marker would be preferable to clinical and radiological scoring systems. The aim of this study was to undertake a meta-analysis on the value of carboxypeptidase-B activation peptide (CAPAP) in predicting severity of acute pancreatitis on admission. METHODS: Major databases and trial registries were searched to identify all relevant studies from January 1998 to March 2015...
July 2015: Clinical Biochemistry
Jian Huang, Zhengwang Wu, Shiqi Lu, Jiaqing Shen, Xiaoming Kong, Yueping Shen
The clinical usefulness of soluble B7-H2 (sB7-H2) as an early indicator of acute pancreatitis (AP) remains unclear, so we performed the present study to investigate this issue. For our cohort, we recruited 75 patients with AP, 70 patients with other abdominal sepsis, and 20 healthy control individuals. The sB7-H2 levels of AP patients or healthy control individuals were measured by enzyme-linked immunosorbent assay (ELISA). The sB7-H2 levels in patients with AP rather than other patients with abdominal sepsis were significantly higher than those in healthy controls...
2015: Laboratory Medicine
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