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https://www.readbyqxmd.com/read/28448998/efficacy-safety-and-tolerability-of-armodafinil-therapy-for-hypersomnia-associated-with-dementia-with-lewy-bodies-a-pilot-study
#1
Maria I Lapid, Karen M Kuntz, Sara S Mason, Jeremiah A Aakre, Emily S Lundt, Walter Kremers, Laura A Allen, Daniel A Drubach, Bradley F Boeve
BACKGROUND/AIMS: Hypersomnia is common in dementia with Lewy bodies (DLB). We assessed the efficacy, safety, and tolerability of armodafinil for hypersomnia associated with DLB. METHODS: We performed a 12-week pilot trial of armodafinil therapy (125-250 mg orally daily) in DLB outpatients with hypersomnia. The patients underwent neurologic examinations, a neuropsychological battery, laboratory testing, electrocardiography, and polysomnography. Efficacy was assessed at 2, 4, 8, and 12 weeks...
April 28, 2017: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/28448949/utility-of-the-fitbit-flex-to-evaluate-sleep-in-major-depressive-disorder-a-comparison-against-polysomnography-and-wrist-worn-actigraphy
#2
Jesse D Cook, Michael L Prairie, David T Plante
BACKGROUND: Sleep disturbance is a common and important component of affective illness. Fitness activity trackers are emerging as alternative means to estimate sleep in psychiatric patients; however, their ability to quantify sleep in mood disorders has not been empirically evaluated. Thus, this study sought to evaluate the utility of the Fitbit Flex (FBF) to estimate sleep in patients with major depressive disorder (MDD) relative to gold standard polysomnography (PSG) and a widely-used actigraph (Actiwatch-2; AW-2)...
April 19, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28448332/sleep-quality-and-quantity-in-low-income-postpartum-women
#3
Jennifer J Doering, Aniko Szabo, Deepika Goyal, Elizabeth Babler
PURPOSE: To describe and explore patterns of postpartum sleep, fatigue, and depressive symptoms in low-income urban women. STUDY DESIGN AND METHODS: In this descriptive, exploratory, nonexperimental study, participants were recruited from an inpatient postpartum unit. Subjective measures were completed by 132 participants across five time points. Objective sleep/wake patterns were measured by 72-hour wrist actigraphy at 4 and 8 weeks. Mean sample age was 25 years, high school educated with 3...
May 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/28447818/correction-to-weststrate-and-gl%C3%A3-ck-2017
#4
(no author information available yet)
Reports an error in "Hard-earned wisdom: Exploratory processing of difficult life experience is positively associated with wisdom" by Nic M. Weststrate and Judith Glück (Developmental Psychology, 2017[Apr], Vol 53[4], 800-814). (The following abstract of the original article appeared in record 2017-12497-007.) Laypersons and experts believe that wisdom is cultivated through a diverse range of positive and negative life experiences. Yet, not all individuals with life experience are wise. We propose that one possible determinant of growth in wisdom from life experience is self-reflection...
April 27, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28446773/therapeutic-effects-of-anti-hmgb1-monoclonal-antibody-on-pilocarpine-induced-status-epilepticus-in-mice
#5
Li Fu, Keyue Liu, Hidenori Wake, Kiyoshi Teshigawara, Tadashi Yoshino, Hideo Takahashi, Shuji Mori, Masahiro Nishibori
Inflammatory processes in brain tissue have been described in human epilepsy of various etiologies and in experimental models of seizures. High mobility group box-1 (HMGB1) is now recognized as representative of damage-associated molecular patterns (DAMPs). In the present study, we focused on whether anti-HMGB1 antibody treatment could relieve status epilepticus- triggered BBB breakdown and inflammation response in addition to the seizure behavior itself. Pilocarpine and methyl-scopolamine were used to establish the acute seizure model...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446040/characteristics-of-socially-withdrawn-youth-in-france-a-retrospective-study
#6
Nicolas Chauliac, Audrey Couillet, Sophie Faivre, Nassima Brochard, Jean-Louis Terra
BACKGROUND: Poor social interactions have been recognized as a symptom since the beginnings of psychiatry. As far as socially withdrawn youth (SWY) are concerned, studies were mostly conducted on patients seeking care. Our psychiatric outreach team called Psymobile was able to reach SWY patients who were not seeking mental health care. AIMS: To identify the clinical and socio-demographic characteristics of SWY patients referred to our Psymobile unit. METHOD: We carried out a retrospective study on the records of patients aged 18-34 years, who were referred to Psymobile for 'withdrawal', between April 2012 and December 2015...
April 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28444788/night-sleep-in-patients-with-vegetative-state
#7
Yuri G Pavlov, Steffen Gais, Friedemann Müller, Monika Schönauer, Barbara Schäpers, Jan Born, Boris Kotchoubey
Polysomnographic recording of night sleep was carried out in 15 patients with the diagnosis vegetative state (syn. unresponsive wakefulness syndrome). Sleep scoring was performed by three raters, and confirmed by means of a spectral power analysis of the electroencephalogram, electrooculogram and electromyogram. All patients but one exhibited at least some signs of sleep. In particular, sleep stage N1 was found in 13 patients, N2 in 14 patients, N3 in nine patients, and rapid eye movement sleep in 10 patients...
April 26, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28444769/lesions-of-the-basal-forebrain-cholinergic-neurons-attenuates-sleepiness-and-adenosine-after-alcohol-consumption
#8
Rishi Sharma, Pradeep Sahota, Mahesh M Thakkar
Alcohol has a profound effect on sleep. However, neuronal substrates mediating sleep-promoting effects of alcohol are unknown. Since the basal forebrain (BF) cholinergic neurons are implicated in the homeostatic regulation of sleep, we hypothesized that the BF cholinergic neurons may have an important role in sleepiness observed after alcohol consumption. 192-IgG-saporin (bilateral BF infusions) was used to selectively lesion BF cholinergic neurons in adult male Sprague Dawley rats. Standard surgical procedures were used to implant sleep recording electrodes or microdialysis guide cannulas...
April 26, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28444767/the-dual-orexin-receptor-antagonist-dora-22-lowers-histamine-levels-in-the-lateral-hypothalamus-and-prefrontal-cortex-without-lowering-hippocampal-acetylcholine
#9
Lihang Leon Yao, Andres Ramirez, Anthony J Roecker, Steven Fox, Jason Uslaner, Sean M Smith, Robert Hodgson, Paul J Coleman, John J Renger, Christopher J Winrow, Anthony L Gotter
Chronic insomnia is defined as a persistent difficulty with sleep initiation maintenance or non-restorative sleep. The therapeutic standard of care for this condition is treatment with gamma-aminobutyric acid (GABA)A receptor modulators, which promote sleep but are associated with a panoply of side effects, including cognitive and memory impairment. Dual orexin receptor antagonists (DORAs) have recently emerged as an alternative therapeutic approach that acts via a distinct and more selective wake-attenuating mechanism with the potential to be associated with milder side effects...
April 26, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28444396/circadian-impairment-of-distal-skin-temperature-rhythm-in-patients-with-sleep-disordered-breathing-the-effect-of-cpap
#10
Antonio Martinez-Nicolas, Marc Guaita, Joan Santamaría, Josep M Montserrat, María Ángeles Rol, Juan Antonio Madrid
Study objectives: Our aim was to evaluate the circadian rhythm of distal skin temperature (DST) in Sleep Disordered Breathing (SDB), its relation to excessive daytime sleepiness and the effect of continuous positive airway pressure (CPAP) on DST. Methods: Eighty SDB patients (53.1±1.2 years old, 27.6% women) and 67 healthy subjects (52.3±1.6 years old, 26.9% women) wore a temperature data logger for one week. On the last day of that week, SDB patients underwent a polysomnography followed by a Maintenance of Wakefulness Test (MWT), Multiple Sleep Latency Test (MSLT) and Sustained Attention to Response Task (SART) protocol to objectively quantify daytime sleepiness...
April 22, 2017: Sleep
https://www.readbyqxmd.com/read/28444394/tissue-specific-dissociation-of-diurnal-transcriptome-rhythms-during-sleep-restriction-in-mice
#11
Jana Husse, Jana-Thabea Kiehn, Johanna L Barclay, Nadine Naujokat, Judit Meyer-Kovac, Hendrik Lehnert, Henrik Oster
Study objectives: Shortened or mistimed sleep affects metabolic homeostasis, which may in part be mediated by dysregulation of endogenous circadian clocks. In this study, we assessed the contribution of sleep disruption to metabolic dysregulation by analysing diurnal transcriptome regulation in metabolic tissues of mice subjected to a sleep restriction paradigm. Methods: Male mice were subjected to 2x5 days of sleep restriction (SR) with enforced waking during the first six hours of the light phase...
April 24, 2017: Sleep
https://www.readbyqxmd.com/read/28443994/relationship-between-psychosocial-stress-dimensions-and-salivary-cortisol-in-military-police-officers
#12
Juliana Petri Tavares, Liana Lautert, Tânia Solange Bosi de Souza Magnago, Angélica Rosat Consiglio, Daiane Dal Pai
OBJECTIVE: to analyze the relationship between psychosocial stress dimensions and salivary cortisol in military police officers. METHOD: cross-sectional and analytical study with 134 military police officers. The Effort-Reward Imbalance (ERI) Model scale has been used to assess psychosocial stress. Salivary cortisol was collected in three samples. The following tests were used: Student's t-test, Mann-Whitney, ANOVA, Bonferroni, Kruskal-Wallis and Dunn. Pearson and Spearman correlation methods were used, as well as multiple linear regression...
April 20, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/28443381/pharmacological-management-of-narcolepsy-with-and-without-cataplexy
#13
Ulf Kallweit, Claudio L Bassetti
Introduction Narcolepsy is an orphan neurological disease and presents with sleep- wake, motoric, neuropsychiatric and metabolic symptoms. Narcolepsy with cataplexy is most commonly caused by an immune-mediated process including genetic and environmental factors, resulting in the selective loss of hypocretin-producing neurons. Narcolepsy has a major impact on workableness and quality of life. Areas covered This review provides an overview of the temporal available treatment options for narcolepsy (type 1 and 2) in adults, including authorization status by regulatory agencies...
April 26, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28443005/waking-up-buried-memories-of-old-tv-programs
#14
Christelle Larzabal, Nadège Bacon-Macé, Sophie Muratot, Simon J Thorpe
Although it has been demonstrated that visual and auditory stimuli can be recalled decades after the initial exposure, previous studies have generally not ruled out the possibility that the material may have been seen or heard during the intervening period. Evidence shows that reactivations of a long-term memory trace play a role in its update and maintenance. In the case of remote or very long-term memories, it is most likely that these reactivations are triggered by the actual re-exposure to the stimulus...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28442311/sleep-phase-delay-in-cystic-fibrosis-a-potential-new-manifestation-of-cystic-fibrosis-transmembrane-regulator-dysfunction
#15
Judy L Jensen, Christopher R Jones, Christiana Kartsonaki, Kristyn A Packer, Frederick R Adler, Theodore G Liou
BACKGROUND: Cystic fibrosis (CF) transmembrane regulator (CFTR) protein dysfunction causes CF. Improving survival allows detection of increasingly subtle disease manifestations. CFTR dysfunction in the central nervous system (CNS) may disturb circadian rhythm and thus sleep phase. We studied sleep in adults to better understand potential CNS CFTR dysfunction. METHODS: We recruited participants from April 2012 through April 2015 and administered the Munich Chronotype Questionnaire (MCTQ)...
April 22, 2017: Chest
https://www.readbyqxmd.com/read/28441236/the-new-mirus-system-for-short-term-sedation-in-postsurgical-icu-patients
#16
Stefano Romagnoli, Cosimo Chelazzi, Gianluca Villa, Giovanni Zagli, Francesco Benvenuti, Paola Mancinelli, Giulio Arcangeli, Stefano Dugheri, Alessandro Bonari, Lorenzo Tofani, Andrea Belardinelli, A Raffaele De Gaudio
OBJECTIVES: To evaluate the feasibility and safety of the MIRUS system (Pall International, Sarl, Fribourg, Switzerland) for sedation with sevoflurane for postsurgical ICU patients and to evaluate atmospheric pollution during sedation. DESIGN: Prospective interventional study. SETTING: Surgical ICU. February 2016 to December 2016. PATIENTS: Postsurgical patients requiring ICU admission, mechanical ventilation, and sedation...
April 22, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28440811/evaluation-of-circadian-phenotypes-utilizing-fibroblasts-from-patients-with-circadian-rhythm-sleep-disorders
#17
A Hida, Y Ohsawa, S Kitamura, K Nakazaki, N Ayabe, Y Motomura, K Matsui, M Kobayashi, A Usui, Y Inoue, H Kusanagi, Y Kamei, K Mishima
We evaluated the circadian phenotypes of patients with delayed sleep-wake phase disorder (DSWPD) and non-24-hour sleep-wake rhythm disorder (N24SWD), two different circadian rhythm sleep disorders (CRSDs) by measuring clock gene expression rhythms in fibroblast cells derived from individual patients. Bmal1-luciferase (Bmal1-luc) expression rhythms were measured in the primary fibroblast cells derived from skin biopsy samples of patients with DSWPD and N24SWD, as well as control subjects. The period length of the Bmal1-luc rhythm (in vitro period) was distributed normally and was 22...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28440048/ability-to-adjust-nocturnal-fat-oxidation-in-response-to-overfeeding-predicts-5-year-weight-gain-in-adults
#18
Corey A Rynders, Audrey Bergouignan, Elizabeth Kealey, Daniel H Bessesen
OBJECTIVE: To determine whether metabolic responses to short-term overfeeding predict longitudinal changes in body weight. METHODS: Twenty-four-hour energy expenditure (EE) and substrate utilization were measured at baseline in a room calorimeter following 3 days of eucaloric and hypercaloric feeding (40% excess) in a sample of lean adults (n: 34; age: 28 ± 2 y; BMI: 22 ± 3 kg/m(2) ). Body mass and fat mass (dual-energy x-ray absorptiometry) were measured annually for 5 years...
May 2017: Obesity
https://www.readbyqxmd.com/read/28439595/the-association-between-pain-and-sleep-in-fibromyalgia
#19
Buse Keskindag, Meryem Karaaziz
To clarify the association between pain and sleep in fibromyalgia.  Methods: Electronic databases, including PsycINFO, the Cochrane database for systematic reviews, PubMed, EMBASE, and Ovid were searched to identify eligible articles. Databases independently screened and  the quality of evidence using a reliable and valid quality assessment tool was assessed.  Results: In total, 16 quantitative studies fulfilled the inclusion criteria. According to the results, increased pain in fibromyalgia was associated with reduced sleep quality, efficiency, and duration and increased sleep disturbance and onset latency and total wake time...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28439594/the-effect-of-chronotherapy-on-depressive-symptoms-evidence-based-practice
#20
Anas H Khalifeh
The global prevalence of depression is increasing, along with rates of depression-associated disability and mortality, rendering depressive disorders a major public health issue. Chronotherapy involves a variety of strategies that control exposure to environmental stimuli that influence the biological clock, such as sleep deprivation (SD) or wake therapy (WT), sleep phase advance (SPA), and light and dark therapy (LT, DT). The purpose of this Evidence-Based Practice (EBP) paper is to answer PICOT questions by a review the effectiveness of chronotherapeutics interventions on depressive symptoms with depression and the depressive episode in the course of bipolar disorder...
May 2017: Saudi Medical Journal
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