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https://www.readbyqxmd.com/read/28740426/efficacy-of-flurbiprofen-8-75-mg-delivered-as-a-spray-or-lozenge-in-patients-with-sore-throat-due-to-upper-respiratory-tract-infection-a-randomized-non-inferiority-trial-in-the-russian-federation
#1
Eugenia Radkova, Natalia Burova, Valeria Bychkova, Robert DeVito
OBJECTIVE: To assess the efficacy of flurbiprofen 8.75 mg delivered as a spray or lozenge in patients with sore throat due to upper respiratory tract infection (URTI). MATERIALS AND METHODS: This multicenter, double-blind, double-dummy, non-inferiority study randomized 440 adults with recent-onset, moderate-to-severe sore throat due to URTI to a single dose of either flurbiprofen 8.75 mg spray (n=218) or flurbiprofen 8.75 mg lozenge (n=222). The presence or absence of beta-hemolytic streptococci (A or C) was confirmed by culture tests (throat swab)...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28732495/carriage-and-serotype-distribution-of-streptococcus-agalactiae-in-third-trimester-pregnancy-in-southern-ghana
#2
Hans-Christian Slotved, Nicholas T K D Dayie, Josephine A N Banini, Niels Frimodt-Møller
BACKGROUND: The aim of this study was to determine the prevalence of Streptococcus agalactiae (group B streptococci, GBS) among healthy, pregnant women attending antenatal care at different study sites in the Greater Accra Region, Ghana. METHODS: Between 2010 and June 2013, recto-vaginal swab samples were collected from pregnant women attending antenatal care from two study sites in southern Ghana. The samples were collected within 35 and 37 weeks of the gestation period...
July 21, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28725564/post-partum-streptococcal-toxic-shock-syndrome-associated-with-necrotizing-fasciitis
#3
Wei Chuan Chua, Mohd Zulfakar Mazlan, Saedah Ali, Sanihah Che Omar, Wan Mohd Nazaruddin Wan Hassan, S Praveena Seevaunnantum, Rhendra Hardy Mohd Zaini, Mohd Hasyizan Hassan, Alwi Muhd Besari, Zaidah Abd Rahman, Zeti Norfidiyati Salmuna Ayub, Sabrina Abd Ghani, Normalinda Yaacob, Wan Rosilawati Wan Rosli
We report a fatal case of post-partum streptococcal toxic shock syndrome in a patient who was previously healthy and had presented to the emergency department with an extensive blistering ecchymotic lesions over her right buttock and thigh associated with severe pain. The pregnancy had been uncomplicated, and the mode of delivery had been spontaneous vaginal delivery with an episiotomy. She was found to have septicemic shock requiring high inotropic support. Subsequently, she was treated for necrotizing fasciitis, complicated by septicemic shock and multiple organ failures...
2017: IDCases
https://www.readbyqxmd.com/read/28709393/microbiome-associated-with-severe-caries-in-canadian-first-nations-children
#4
M Agnello, J Marques, L Cen, B Mittermuller, A Huang, N Chaichanasakul Tran, W Shi, X He, R J Schroth
Young Indigenous children in North America suffer from a higher degree of severe early childhood caries (S-ECC) than the general population, leading to speculation that the etiology and characteristics of the disease may be distinct in this population. To address this knowledge gap, we conducted the first microbiome analysis of an Indigenous population using modern molecular techniques. We investigated the caries-associated microbiome among Canadian First Nations children with S-ECC. Thirty First Nations children <72 mo of age with S-ECC and 20 caries-free children were recruited in Winnipeg, Canada...
July 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28705799/rapid-developing-empyema-by-group-f-beta-streptococcus-anginosus-group
#5
Muhammad Azharuddin, Dy Prudence, Prem Shanker Shukla, Ajay Mathur
A 43-year-old male had progressive pleuritic left-sided chest tightness with shortness of breath. He had dental caries and tenderness on palpation of the left lateral chest. Complete blood count showed leucocytosis. CT scan of the chest with pulmonary emboli protocol showed multiple pulmonary nodules and nodular pleural thickening at left posterior lateral pleura. Forty-eight hours post CTPE scan, CT scan of the chest, abdomen and pelvis displayed right lower lobe consolidation and left-sided pleural effusion with superimposed compressive atelectasis...
July 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28683409/thymus-vulgaris-l-extract-has-antimicrobial-and-anti-inflammatory-effects-in-the-absence-of-cytotoxicity-and-genotoxicity
#6
Jonatas Rafael de Oliveira, Daiane de Jesus Viegas, Ana Paula Réquia Martins, Cláudio Antonio Talge Carvalho, Cristina Pacheco Soares, Samira Esteves Afonso Camargo, Antonio Olavo Cardoso Jorge, Luciane Dias de Oliveira
OBJECTIVES: This study evaluated the biological effects of the T. vulgaris L. extract., such as antimicrobial activity on planktonic cultures and mono- and polymicrobial biofilms, cytotoxicity, anti-inflammatory activity and genotoxicity. METHODS: Monomicrobial biofilms of Candida albicans, Staphylococcus aureus, Enterococcus faecalis, Streptococcus mutans and Pseudomonas aeruginosa and polymicrobial biofilms composed by C. albicans with each bacterium were formed for 48h and exposed for 5min to the plant extract...
June 27, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28584706/impact-of-enzymatic-digestion-on-bacterial-community-composition-in-cf-airway-samples
#7
Kayla M Williamson, Brandie D Wagner, Charles E Robertson, Emily J Johnson, Edith T Zemanick, J Kirk Harris
BACKGROUND: Previous studies have demonstrated the importance of DNA extraction methods for molecular detection of Staphylococcus, an important bacterial group in cystic fibrosis (CF). We sought to evaluate the effect of enzymatic digestion (EnzD) prior to DNA extraction on bacterial communities identified in sputum and oropharyngeal swab (OP) samples from patients with CF. METHODS: DNA from 81 samples (39 sputum and 42 OP) collected from 63 patients with CF was extracted in duplicate with and without EnzD...
2017: PeerJ
https://www.readbyqxmd.com/read/28553185/acute-hematogenous-osteomyelitis-presenting-as-a-cold-rib-in-a-child
#8
Michael J Annen, Mickaila J Johnston, Joe P Gormley, Eugene Silverman
A "cold" defect or an area of decreased radiotracer deposition is the less common appearance of acute hematogenous osteomyelitis (AHO) on a Tc99 m-methylene disphosphonate (Tc99 m-MDP) bone scan. Group A beta-hemolytic Streptococcus (GABHS) is a significantly less common cause of AHO than Staphylococcus aureus, particularly when the infection involves the pelvis or flat bones such as the ribs. Here, we present a case report of isolated acute "cold" hematogenous osteomyelitis in a rib of a child with GABHS bacteremia that was detected on 99Tc-MDP bone scan, with magnetic resonance imaging correlation, and pathologic confirmation after rib resection...
April 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28507066/the-microbiome-of-site-specific-dental-plaque-of-children-with-different-caries-status
#9
Vincent P Richards, Andres J Alvarez, Amy R Luce, Molly Bedenbaugh, Mary Mitchell, Robert A Burne, Marcelle M Nascimento
The oral microbiota associated with the initiation and progression of dental caries has yet to be fully characterized. The Human Oral Microbe Identification using Next Generation Sequencing (HOMINGS) was used to analyze the microbiomes of site-specific supragingival dental plaques from children with different caries status. Fifty-five children (2-7 years) were assessed at baseline and 12-months, and grouped as: caries-free (CF), caries-active with enamel lesions (CAE), and caries-active with dentin carious lesions (CA)...
May 15, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28384093/antimicrobial-susceptibility-monitoring-of-bacterial-pathogens-isolated-from-urinary-tract-infections-in-dogs-and-cats-across-europe-compath-results
#10
Hilde Moyaert, Ian Morrissey, Anno de Jong, Farid El Garch, Ulrich Klein, Carolin Ludwig, Julien Thiry, Myriam Youala
ComPath is a pan-European antimicrobial surveillance program collecting bacterial pathogens from dogs and cats not recently exposed to antimicrobials. We present minimum inhibitory concentration data obtained using Clinical and Laboratory Standards Institute methodology for 616 urinary tract infection (UTI) isolates collected between 2008 and 2010. In both dogs and cats, the most common pathogen was Escherichia coli (59.8% and 46.7%, respectively). Antimicrobial activity against E. coli in dogs and cats was similar with fluoroquinolone and trimethoprim/sulfamethoxazole susceptibility >90%...
April 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/28381239/prevalence-of-group-a-streptococcus-pharyngeal-carriage-and-clinical-manifestations-in-school-children-aged-5-15%C3%A2-yrs-in-wakiso-district-uganda
#11
Irene Nayiga, Emmy Okello, Peter Lwabi, Grace Ndeezi
BACKGROUND: Beta-hemolytic streptococci carrier rates in children living in low-income countries are high ranging from 10 to 50%. Although most of these children are asymptomatic, they are a reservoir and pose a risk of transmission. The aim of this study was to determine the prevalence of group a streptococcus pharyngeal carriage and clinical manifestations in school going children in Wakiso district, Uganda. METHODS: A cross sectional study targeting children age 5-15 years in primary schools in one sub-county of Wakiso district was carried out...
April 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28376443/prevalence-of-group-c-streptococcus-and-fusobacterium-necrophorum-in-patients-with-sore-throat-a-meta-analysis
#12
REVIEW
Christian Marchello, Mark H Ebell
PURPOSE: The prevalence of Group C beta-hemolytic streptococcus and Fusobacterium necrophorum among patients with sore throat in the outpatient setting has not been previously summarized. We set out to derive prevalence information from the existing literature. METHODS: We performed a systematic review of MEDLINE for studies reporting the prevalence of F necrophorum or Group C streptococcus or both in prospective, consecutive series of outpatients with sore throat, as well as laboratory-based studies of throat cultures submitted from primary care...
November 2016: Annals of Family Medicine
https://www.readbyqxmd.com/read/28304211/furcation-therapy-with-enamel-matrix-derivative-effects-on-the-subgingival-microbiome
#13
Lucas A Queiroz, Renato C V Casarin, Shareef M Dabdoub, Dimitris N Tatakis, Enilson A Sallum, Purnima S Kumar
BACKGROUND: Although enamel matrix derivative (EMD) has been used to promote periodontal regeneration, little is known of its effect on the microbiome. Therefore, this investigation aims to identify changes in periodontal microbiome after treatment with EMD using a deep-sequencing approach. METHODS: Thirty-nine patients with mandibular Class II buccal furcation defects were randomized to beta-tricalcium-phosphate/hydroxyapatite graft (BONE group), EMD+BONE, or EMD alone...
July 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28288328/case-control-exploratory-study-of-cerebrospinal-fluid-chemokines-cytokines-and-lymphocyte-subsets-in-childhood-tourette-syndrome-with-positive-streptococcal-markers
#14
Michael R Pranzatelli, Elizabeth D Tate, Tyler J Allison
A longstanding question is whether neuroinflammation is present in children symptomatic for Tourette syndrome (TS) with positive streptococcal serology and throat cultures. The objective was to directly test for it using modern hypothesis-driven approaches. Profiling studies for 14 immune cell types (flow cytometry), 7 chemokines/cytokines (ELISA), oligoclonal bands, and other immunoglobulins were performed in this IRB-approved study of 5 children with TS and streptococcal markers compared to data from 26 non-inflammatory pediatric neurological controls...
March 10, 2017: Cytokine
https://www.readbyqxmd.com/read/28283012/-evaluation-of-mascia-brunelli-rapid-antigen-test-in-the-diagnosis-of-group-a-streptococcal-pharyngitis
#15
Ayşe Barış, Nur Anlıaçık, Mehmet Emin Bulut, Rıdvan Deniz, Elif Yücel, Elif Aktaş
Pharyngitis in most cases is due to viral microorganisms however drug therapy without the detection of etiological agent leads to unnecessary use of antibiotics. On the other hand, when the etiologic agent is group A beta-hemolytic streptococci (GAS) it is important to identify the etiologic agent rapidly which will guide the treatment with appropriate antibiotics. The use of highly sensitive rapid tests will contribute significantly to early diagnosis and appropriate therapy. The aim of this study is to evaluate the efficacy of Mascia Brunelli rapid antigen test for the detection of GAS in throat swab samples...
January 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28263195/toenail-bracing-complicated-with-group-a-beta-haemolytic-streptococcus-infection
#16
Anca Chiriac, Cristina Birsan, Calin Molnar, Simona Stolnicu
No abstract text is available yet for this article.
March 2, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28207813/interacting-networks-of-resistance-virulence-and-core-machinery-genes-identified-by-genome-wide-epistasis-analysis
#17
Marcin J Skwark, Nicholas J Croucher, Santeri Puranen, Claire Chewapreecha, Maiju Pesonen, Ying Ying Xu, Paul Turner, Simon R Harris, Stephen B Beres, James M Musser, Julian Parkhill, Stephen D Bentley, Erik Aurell, Jukka Corander
Recent advances in the scale and diversity of population genomic datasets for bacteria now provide the potential for genome-wide patterns of co-evolution to be studied at the resolution of individual bases. Here we describe a new statistical method, genomeDCA, which uses recent advances in computational structural biology to identify the polymorphic loci under the strongest co-evolutionary pressures. We apply genomeDCA to two large population data sets representing the major human pathogens Streptococcus pneumoniae (pneumococcus) and Streptococcus pyogenes (group A Streptococcus)...
February 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28201995/zoonotic-necrotizing-myositis-caused-by-streptococcus-equi-subsp-zooepidemicus-in-a-farmer
#18
Bård Reiakvam Kittang, Veronika Kuchařová Pettersen, Oddvar Oppegaard, Dag Harald Skutlaberg, Håvard Dale, Harald G Wiker, Steinar Skrede
BACKGROUND: Streptococcus equi subsp. zooepidemicus is a beta-hemolytic group C streptococcus mainly causing infections in domesticated animals. Here we describe the first case of zoonotic necrotizing myositis caused by this bacterium. CASE PRESENTATION: The patient was a 73-year-old, previously healthy farmer with two asymptomatic Shetland ponies in his stable. After close contact with the ponies while feeding them, he rapidly developed erythema of his left thigh and sepsis with multiple organ failure...
February 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28164610/an-investigation-of-the-frequency-of-upper-respiratory-tract-infection-pathogens-and-their-antibiotic-patterns-in-tonsils-and-adenoids-of-adenotonsillectomy-patients
#19
Yasar Nakipoglu, Gulsen Gunel, Deniz Kanliada, Levent Aydemir, Nezahat Gurler, Bulent Gurler
BACKGROUND: We aimed to investigate the potentially pathogenic bacteria of upper respiratory tract infections (URTIs) and their susceptibilities to different antibiotics. METHODS: Two-hundred adenoid and tonsil specimens from 100 patients who had undergone adenotonsillectomy were obtained and analyzed bacteriologically. Identification of the pathogens was made by conventional or commercial identification systems and antibiotic susceptibility tests were carried out by disk diffusion method...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28107528/nasopharyngeal-microbiome-diversity-changes-over-time-in-children-with-asthma
#20
Marcos Pérez-Losada, Lamia Alamri, Keith A Crandall, Robert J Freishtat
BACKGROUND: The nasopharynx is a reservoir for pathogens associated with respiratory illnesses such as asthma. Next-generation sequencing (NGS) has been used to characterize the nasopharyngeal microbiome of infants and adults during health and disease; less is known, however, about the composition and temporal dynamics (i.e., longitudinal variation) of microbiotas from children and adolescents. Here we use NGS technology to characterize the nasopharyngeal microbiomes of asthmatic children and adolescents (6 to 18 years) and determine their stability over time...
2017: PloS One
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