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https://www.readbyqxmd.com/read/28453916/digital-technology-and-clinical-decision-making-in-depression-treatment-current-findings-and-future-opportunities
#1
REVIEW
Kevin A Hallgren, Amy M Bauer, David C Atkins
Clinical decision making encompasses a broad set of processes that contribute to the effectiveness of depression treatments. There is emerging interest in using digital technologies to support effective and efficient clinical decision making. In this paper, we provide "snapshots" of research and current directions on ways that digital technologies can support clinical decision making in depression treatment. Practical facets of clinical decision making are reviewed, then research, design, and implementation opportunities where technology can potentially enhance clinical decision making are outlined...
April 28, 2017: Depression and Anxiety
https://www.readbyqxmd.com/read/28453378/effectiveness-of-written-action-plans-for-acute-asthma-a-systematic-review
#2
Cristina Villa-Roel, Britt Voaklander, Maria B Ospina, Taylor Nikel, Sandra Campbell, Brian H Rowe
OBJECTIVE: Self-management is an essential part of achieving asthma control and improving long-term outcomes. While guidelines recommend the provision of written asthma action plans (AAPs), few patients presenting to emergency departments (ED) have one. This systematic review examined if individualized written AAPs reduce relapses in adults following an ED visit for acute asthma. DATA SOURCES: Comprehensive searches of seven electronic databases and grey literature were conducted...
April 28, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28449010/excess-of-a-rassf1-targeting-microrna-mir-193a-3p-perturbs-cell-division-fidelity
#3
Sofia Pruikkonen, Marko J Kallio
BACKGROUND: Several microRNA (miRNA) molecules have emerged as important post-transcriptional regulators of tumour suppressor and oncogene expression. Ras association domain family member 1 (RASSF1) is a critical tumour suppressor that controls multiple aspects of cell proliferation such as cell cycle, cell division and apoptosis. The expression of RASSF1 is lost in a variety of cancers due to the promoter hypermethylation. METHODS: miR-193a-3p was identified as a RASSF1-targeting miRNA by a dual screening approach...
April 27, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28448225/online-positive-thinking-training-intervention-for-caregivers-of-individuals-with-asd-necessity-acceptability-and-feasibility
#4
Abir K Bekhet
BACKGROUND: More than 3.5 million people in the United States are diagnosed with autism spectrum disorder (ASD). Caring for children with ASD can be stressful and can be detrimental to the well-being of the caregivers (CGs). However, the adverse effects of caregiving on the well-being of CGs may be avoided with appropriate interventions. CGs of persons with ASD might benefit from a positive thinking training (PTT) intervention to help them cope with the stress of caregiving. However, the necessity, acceptability and feasibility for PTT in ASD CGs have not been studied...
May 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28447975/measurement-of-quantum-interference-in-a-silicon-ring-resonator-photon-source
#5
Jeffrey A Steidle, Michael L Fanto, Stefan F Preble, Christopher C Tison, Gregory A Howland, Zihao Wang, Paul M Alsing
Silicon photonic chips have the potential to realize complex integrated quantum information processing circuits, including photon sources, qubit manipulation, and integrated single-photon detectors. Here, we present the key aspects of preparing and testing a silicon photonic quantum chip with an integrated photon source and two-photon interferometer. The most important aspect of an integrated quantum circuit is minimizing loss so that all of the generated photons are detected with the highest possible fidelity...
April 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28447097/rapid-large-area-fabrication-of-multiscale-through-hole-membranes
#6
Dongha Tahk, Sang-Min Paik, Jungeun Lim, Seokyoung Bang, Soojung Oh, Hyunryul Ryu, Noo Li Jeon
There are many proposed mechanisms by which single cells can be trapped; among them is the through-hole membrane for the characterization of individual microorganisms. Due to the small scale of the fabricated pores, the construction of through-hole membranes on a large scale and with relatively large areas faces many difficulties. This paper describes novel fabrication methods for a large-area, freestanding micro/nano through-hole membrane constructed from versatile membrane materials using through-hole membranes on a microfluidic chip (THMMC)...
April 27, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28446775/delivering-prolonged-intensive-care-to-a-non-human-primate-a-high-fidelity-animal-model-of-critical-illness
#7
P Guillaume Poliquin, Mia Biondi, Charlene Ranadheera, Mable Hagan, Alexander Bello, Trina Racine, Mark Allan, Duane Funk, Gregory Hansen, B J Hancock, Murray Kesselman, Todd Mortimer, Anand Kumar, Shane Jones, Anders Leung, Allen Grolla, Kaylie N Tran, Kevin Tierney, Xiangguo Qiu, Darwyn Kobasa, James E Strong
Critical care needs have been rising in recent decades as populations age and comorbidities increase. Sepsis-related admissions to critical care contribute up to 50% of volume and septic shock carries a 35-54% fatality rate. Improvements in sepsis-related care and mortality would have a significant impact of a resource-intensive area of health care delivery. Unfortunately, research has been hampered by the lack of an animal model that replicates the complex care provided to humans in an intensive care unit (ICU)...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446588/hierarchical-differences-in-population-coding-within-auditory-cortex
#8
Joshua David Downer, Mamiko Niwa, Mitchell L Sutter
Most models of auditory cortical (AC) population coding have focused on primary auditory cortex (A1). Thus, our understanding of how neural coding for sounds progresses along the cortical hierarchy remains obscure. To illuminate this, we recorded from AC fields, A1 and middle-lateral belt (ML) of rhesus macaques. We presented amplitude-modulated (AM) noise during both passive listening and while the animals performed an AM detection task ("Active" condition). In both fields, neurons exhibit monotonic AM-depth tuning, with A1 neurons mostly exhibiting increasing rate-depth functions and ML neurons ~evenly distributed between increasing and decreasing functions...
April 26, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28446165/knowledge-exchange-in-the-pacific-outcomes-of-the-tropic-translational-research-for-obesity-prevention-in-communities-project
#9
Peter Kremer, Helen Mavoa, Gade Waqa, Marjory Moodie, Marita McCabe, Boyd Swinburn
BACKGROUND: The Pacific TROPIC (Translational Research for Obesity Prevention in Communities) project aimed to design, implement and evaluate a knowledge-broking approach to evidence-informed policy making to address obesity in Fiji. This paper reports on the quantitative evaluation of the knowledge-broking intervention through assessment of participants' perceptions of evidence use and development of policy/advocacy briefs. METHODS: Selected staff from six organizations - four government Ministries and two nongovernment organizations (NGOs) - participated in the project...
April 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28446119/neurobionics-and-the-brain-computer-interface-current-applications-and-future-horizons
#10
Jeffrey V Rosenfeld, Yan Tat Wong
The brain-computer interface (BCI) is an exciting advance in neuroscience and engineering. In a motor BCI, electrical recordings from the motor cortex of paralysed humans are decoded by a computer and used to drive robotic arms or to restore movement in a paralysed hand by stimulating the muscles in the forearm. Simultaneously integrating a BCI with the sensory cortex will further enhance dexterity and fine control. BCIs are also being developed to: provide ambulation for paraplegic patients through controlling robotic exoskeletons; restore vision in people with acquired blindness; detect and control epileptic seizures; and improve control of movement disorders and memory enhancement...
May 1, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28445206/independent-effects-of-blood-pressure-and-parathyroid-hormone-on-aortic-pulse-wave-velocity-in-untreated-chinese-patients
#11
Yi-Bang Cheng, Li-Hua Li, Qian-Hui Guo, Fei-Ka Li, Qi-Fang Huang, Chang-Sheng Sheng, Ji-Guang Wang, Jan A Staessen, Yan Li
OBJECTIVE: Whether or not calcium-regulating hormones stiffen arteries independent of blood pressure (BP) is uncertain. We investigated the independent associations of carotid-femoral pulse wave velocity (PWV) with 25-hydroxy-vitamin D [25(OH)D], parathyroid hormone (PTH) and 24-h ambulatory BP in untreated Chinese patients. METHODS: Consecutive untreated patients referred for ambulatory BP monitoring were recruited. PWV was measured with a high-fidelity micromanometer and the SphygmoCor software (AtCor Medical, West Ryde, New South Wales, Australia)...
April 25, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28444504/correction-of-parallel-transmission-using-concurrent-rf-and-gradient-field-monitoring
#12
Mustafa Çavuşoğlu, Benjamin Emanuel Dietrich, David Otto Brunner, Markus Weiger, Klaas Paul Pruessmann
OBJECTIVES: The accuracy and precision of the parallel RF excitations are highly dependent on the spatial and temporal fidelity of the magnetic fields involved in spin excitation. The consistency between the nominal and effective fields is typically limited by the imperfections of the employed hardware existing both in the gradient system and the RF chain. In this work, we experimentally presented highly improved spatially tailored parallel excitations by turning the native hardware accuracy challenge into a measurement and control problem using an advanced field camera technology to fully correct parallel RF transmission experiment...
April 25, 2017: Magma
https://www.readbyqxmd.com/read/28443686/combined-clinician-parent-delivery-of-rapid-syllable-transition-rest-treatment-for-childhood-apraxia-of-speech
#13
Donna C Thomas, Patricia McCabe, Kirrie J Ballard
PURPOSE: Although speech-language pathologists use parent-delivered home-practice, little is known about the quality of this practice and its relation to treatment efficacy. This study reports both treatment outcomes and fidelity following combined clinician-parent delivery of Rapid Syllable Transition (ReST) treatment. METHOD: Five children aged 5:1-11:7 with childhood apraxia of speech received 12 treatment sessions; six clinic-based and six at home, using multiple baselines across participants design...
April 26, 2017: International Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28440220/rapid-evolution-of-the-human-mutation-spectrum
#14
Kelley Harris, Jonathan K Pritchard
DNA is a remarkably precise medium for copying and storing biological information. This high fidelity results from the action of hundreds of genes involved in replication, proofreading, and damage repair. Evolutionary theory suggests that in such a system, selection has limited ability to remove genetic variants that change mutation rates by small amounts or in specific sequence contexts. Consistent with this, using SNV variation as a proxy for mutational input, we report here that mutational spectra differ substantially among species, human continental groups and even some closely-related populations...
April 25, 2017: ELife
https://www.readbyqxmd.com/read/28439790/evaluating-fidelity-to-a-modified-niatx-process-improvement-strategy-for-improving-hiv-services-in-correctional-facilities
#15
Jennifer Pankow, Jennifer Willett, Yang Yang, Holly Swan, Richard Dembo, William M Burdon, Yvonne Patterson, Frank S Pearson, Steven Belenko, Linda K Frisman
In a study aimed at improving the quality of HIV services for inmates, an organizational process improvement strategy using change teams was tested in 14 correctional facilities in 8 US states and Puerto Rico. Data to examine fidelity to the process improvement strategy consisted of quantitative ratings of the structural and process components of the strategy and qualitative notes that explicate challenges in maintaining fidelity to the strategy. Fidelity challenges included (1) lack of communication and leadership within change teams, (2) instability in team membership, and (3) issues with data utilization in decision-making to implement improvements to services delivery...
April 24, 2017: Journal of Behavioral Health Services & Research
https://www.readbyqxmd.com/read/28439534/the-arctic-ocean-as-a-dead-end-for-floating-plastics-in-the-north-atlantic-branch-of-the-thermohaline-circulation
#16
Andrés Cózar, Elisa Martí, Carlos M Duarte, Juan García-de-Lomas, Erik van Sebille, Thomas J Ballatore, Victor M Eguíluz, J Ignacio González-Gordillo, Maria L Pedrotti, Fidel Echevarría, Romain Troublè, Xabier Irigoien
The subtropical ocean gyres are recognized as great marine accummulation zones of floating plastic debris; however, the possibility of plastic accumulation at polar latitudes has been overlooked because of the lack of nearby pollution sources. In the present study, the Arctic Ocean was extensively sampled for floating plastic debris from the Tara Oceans circumpolar expedition. Although plastic debris was scarce or absent in most of the Arctic waters, it reached high concentrations (hundreds of thousands of pieces per square kilometer) in the northernmost and easternmost areas of the Greenland and Barents seas...
April 2017: Science Advances
https://www.readbyqxmd.com/read/28438070/creation-of-a-novel-simulator-for-minimally-invasive-neurosurgery-fusion-of-3d-printing-and-special-effects
#17
Peter Weinstock, Roberta Rehder, Sanjay P Prabhu, Peter W Forbes, Christopher J Roussin, Alan R Cohen
OBJECTIVE Recent advances in optics and miniaturization have enabled the development of a growing number of minimally invasive procedures, yet innovative training methods for the use of these techniques remain lacking. Conventional teaching models, including cadavers and physical trainers as well as virtual reality platforms, are often expensive and ineffective. Newly developed 3D printing technologies can recreate patient-specific anatomy, but the stiffness of the materials limits fidelity to real-life surgical situations...
April 25, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28437962/rapidly-reconfigurable-high-fidelity-optical-arbitrary-waveform-generation-in-heterogeneous-photonic-integrated-circuits
#18
Shaoqi Feng, Chuan Qin, Kuanping Shang, Shibnath Pathak, Weicheng Lai, Binbin Guan, Matthew Clements, Tiehui Su, Guangyao Liu, Hongbo Lu, Ryan P Scott, S J Ben Yoo
This paper demonstrates rapidly reconfigurable, high-fidelity optical arbitrary waveform generation (OAWG) in a heterogeneous photonic integrated circuit (PIC). The heterogeneous PIC combines advantages of high-speed indium phosphide (InP) modulators and low-loss, high-contrast silicon nitride (Si<sub>3</sub>N<sub>4</sub>) arrayed waveguide gratings (AWGs) so that high-fidelity optical waveform syntheses with rapid waveform updates are possible. The generated optical waveforms spanned a 160 GHz spectral bandwidth starting from an optical frequency comb consisting of eight comb lines separated by 20 GHz channel spacing...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437911/investigation-of-third-order-dispersion-of-long-range-surface-plasmon-polariton-waveguides-using-a-hong-ou-mandel-interferometer
#19
Takahide Sakaidani, Ryo Kobayashi, Naoto Namekata, Go Fujii, Daiji Fukuda, Shuichiro Inoue
High-order dispersion of long-range surface-plasmon-polariton waveguides (LR-SPP-WGs) have been investigated using a two-photon interferometer. Since linear and even-ordered dispersions in two-photon interferometry are cancelled out by a nonlocal quantum correlation, odd-ordered dispersions of millimeter-long LR-SPP-WGs are revealed. Even under the highly dispersive condition, the indistinguishability between two photons emerged from LR-SPP-WGs was well preserved. In addition, we demonstrated a strong polarization-selection by the LR-SPP-WGs that leads to the polarization-stable and high-fidelity quantum interference...
April 17, 2017: Optics Express
https://www.readbyqxmd.com/read/28437262/loss-of-resistance-a-randomised-controlled-trial-assessing-four-low-fidelity-epidural-puncture-simulators
#20
Tina H Pedersen, Jonas Meuli, Eike J Plazikowski, Maximilian Buttenberg, Maren Kleine-Brueggeney, Christian Seidl, Lorenz Theiler, Robert Greif
BACKGROUND: Detecting loss of resistance (LOR) can either be taught with dedicated simulators, with a cost ranging from &OV0556;1500 to 3000, or with the 'Greengrocer's Model', requiring simply a banana. OBJECTIVES: The purpose of this study was to compare three dedicated epidural puncture training simulators and a banana in their ability to simulate LOR. Our hypothesis was that there was a difference between the four simulators when comparing the detection of LOR...
April 21, 2017: European Journal of Anaesthesiology
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