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https://www.readbyqxmd.com/read/29777617/simulation-in-urology-to-train-non-technical-skills-in-ward-rounds
#1
K Somasundram, H Spence, A J Colquhoun, C Mcilhenny, C S Biyani, S Jain
OBJECTIVE: We have designed an exercise to train newly appointed Urology trainees in non-technical skills on ward rounds as a part of a simulation 'boot camp'. This paper reports our experience, including a qualitative analysis of participant feedback on the utility of this method of training. PATIENTS AND METHODS: The simulations took place in a high-fidelity simulated ward bay. Forty-eight doctors with formal Urology training ranging between 2-60 months (mean 19...
May 19, 2018: BJU International
https://www.readbyqxmd.com/read/29776097/modeling-flow-and-transport-in-fracture-networks-using-graphs
#2
S Karra, D O'Malley, J D Hyman, H S Viswanathan, G Srinivasan
Fractures form the main pathways for flow in the subsurface within low-permeability rock. For this reason, accurately predicting flow and transport in fractured systems is vital for improving the performance of subsurface applications. Fracture sizes in these systems can range from millimeters to kilometers. Although modeling flow and transport using the discrete fracture network (DFN) approach is known to be more accurate due to incorporation of the detailed fracture network structure over continuum-based methods, capturing the flow and transport in such a wide range of scales is still computationally intractable...
March 2018: Physical Review. E
https://www.readbyqxmd.com/read/29775362/highly-efficient-coherent-optical-memory-based-on-electromagnetically-induced-transparency
#3
Ya-Fen Hsiao, Pin-Ju Tsai, Hung-Shiue Chen, Sheng-Xiang Lin, Chih-Chiao Hung, Chih-Hsi Lee, Yi-Hsin Chen, Yong-Fan Chen, Ite A Yu, Ying-Cheng Chen
Quantum memory is an important component in the long-distance quantum communication based on the quantum repeater protocol. To outperform the direct transmission of photons with quantum repeaters, it is crucial to develop quantum memories with high fidelity, high efficiency and a long storage time. Here, we achieve a storage efficiency of 92.0 (1.5)% for a coherent optical memory based on the electromagnetically induced transparency scheme in optically dense cold atomic media. We also obtain a useful time-bandwidth product of 1200, considering only storage where the retrieval efficiency remains above 50%...
May 4, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29774300/epidemiology-of-intestinal-parasite-infections-in-three-departments-of-south-central-c%C3%A3-te-d-ivoire-before-the-implementation-of-a-cluster-randomised-trial
#4
Gaoussou Coulibaly, Mamadou Ouattara, Kouassi Dongo, Eveline Hürlimann, Fidèle K Bassa, Naférima Koné, Clémence Essé, Richard B Yapi, Bassirou Bonfoh, Jürg Utzinger, Giovanna Raso, Eliézer K N'Goran
Hundreds of millions of people are infected with helminths and intestinal protozoa, particularly children in low- and middle-income countries. Preventive chemotherapy is the main strategy to control helminthiases. However, rapid re-infection occurs in settings where there is a lack of clean water, sanitation and hygiene. In August and September 2014, we conducted a cross-sectional epidemiological survey in 56 communities of three departments of south-central Côte d'Ivoire. Study participants were invited to provide stool and urine samples...
May 2018: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29774288/molecular-analysis-of-giardia-duodenalis-isolates-from-symptomatic-and-asymptomatic-children-from-la-habana-cuba
#5
Luis Enrique Jerez Puebla, Fidel A Núñez, Lissette Pérez Santos, Lázara Rojas Rivero, Isabel Martínez Silva, Lucía Ayllón Valdés, Iraís Atencio Millán, Norbert Müller
Giardiasis is considered the most common intestinal parasitic disease in humans worldwide. In Cuba, this infection has particularly a strong clinical impact on the child population. Giardia duodenalis is a highly diverse protozoan, which comprises a complex of eight morphologically identical genetic assemblages, further divided into sub-assemblages. The present study used triose phosphate isomerase ( tpi ) and small-subunit ribosomal RNA (SSU rRNA) genes as genetic markers for the identification of G. duodenalis assemblages and sub-assemblages in correlation with clinical and epidemiological data in children attended at the Paediatric Hospital "William Soler" and at Pedro Kouri Institute, between 2015 and 2016...
August 2017: Parasite Epidemiology and Control
https://www.readbyqxmd.com/read/29770454/streamlining-a-blood-center-and-hospital-transfusion-service-supply-chain-with-an-informatics-vendor-managed-inventory-solution-development-implementation-and-3-month-follow-up
#6
Hamilton C Tsang, Adam Garcia, Robert Scott, David Lancaster, Dianne Geary, Anh-Thu Nguyen, Raina Shankar, Leslie Buchanan, Tho D Pham
BACKGROUND: The ordering process at Stanford Health Care involved twice-daily shipments predicated upon current stock levels from the blood center to the hospital transfusion service. Manual census determination is time consuming and error prone. We aimed to enhance inventory management by developing an informatics platform to streamline the ordering process and reallocate staff productivity. STUDY DESIGN AND METHODS: The general inventory accounts for more than 50 product categories based on characteristics including component, blood type, irradiation status, and cytomegalovirus serology status...
May 16, 2018: Transfusion
https://www.readbyqxmd.com/read/29769718/ankrd16-prevents-neuron-loss-caused-by-an-editing-defective-trna-synthetase
#7
My-Nuong Vo, Markus Terrey, Jeong Woong Lee, Bappaditya Roy, James J Moresco, Litao Sun, Hongjun Fu, Qi Liu, Thomas G Weber, John R Yates, Kurt Fredrick, Paul Schimmel, Susan L Ackerman
Editing domains of aminoacyl tRNA synthetases correct tRNA charging errors to maintain translational fidelity. A mutation in the editing domain of alanyl tRNA synthetase (AlaRS) in Aars sti mutant mice results in an increase in the production of serine-mischarged tRNAAla and the degeneration of cerebellar Purkinje cells. Here, using positional cloning, we identified Ankrd16, a gene that acts epistatically with the Aars sti mutation to attenuate neurodegeneration. ANKRD16, a vertebrate-specific protein that contains ankyrin repeats, binds directly to the catalytic domain of AlaRS...
May 16, 2018: Nature
https://www.readbyqxmd.com/read/29769593/east-asian-warm-season-temperature-variations-over-the-past-two-millennia
#8
Huan Zhang, Johannes P Werner, Elena García-Bustamante, Fidel González-Rouco, Sebastian Wagner, Eduardo Zorita, Klaus Fraedrich, Johann H Jungclaus, Fredrik Charpentier Ljungqvist, Xiuhua Zhu, Elena Xoplaki, Fahu Chen, Jianping Duan, Quansheng Ge, Zhixin Hao, Martin Ivanov, Lea Schneider, Stefanie Talento, Jianglin Wang, Bao Yang, Jürg Luterbacher
East Asia has experienced strong warming since the 1960s accompanied by an increased frequency of heat waves and shrinking glaciers over the Tibetan Plateau and the Tien Shan. Here, we place the recent warmth in a long-term perspective by presenting a new spatially resolved warm-season (May-September) temperature reconstruction for the period 1-2000 CE using 59 multiproxy records from a wide range of East Asian regions. Our Bayesian Hierarchical Model (BHM) based reconstructions generally agree with earlier shorter regional temperature reconstructions but are more stable due to additional temperature sensitive proxies...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769292/a-genome-wide-assay-specifies-only-grea-as-a-transcription-fidelity-factor-in-escherichia-coli
#9
Charles C Traverse, Howard Ochman
Although mutations are the basis for adaptation and heritable genetic change, transient errors occur during transcription at rates that are orders of magnitude higher than the mutation rate. High rates of transcription errors can be detrimental by causing the production of erroneous proteins that need to be degraded. Two transcription fidelity factors, GreA and GreB, have previously been reported to stimulate the removal of errors that occur during transcription, and a third fidelity factor, DksA, is thought to decrease the error rate through an unknown mechanism...
May 16, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29769096/a-methodology-for-generating-a-tailored-implementation-blueprint-an-exemplar-from-a-youth-residential-setting
#10
Cara C Lewis, Kelli Scott, Brigid R Marriott
BACKGROUND: Tailored implementation approaches are touted as more likely to support the integration of evidence-based practices. However, to our knowledge, few methodologies for tailoring implementations exist. This manuscript will apply a model-driven, mixed methods approach to a needs assessment to identify the determinants of practice, and pilot a modified conjoint analysis method to generate an implementation blueprint using a case example of a cognitive behavioral therapy (CBT) implementation in a youth residential center...
May 16, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29769080/a-complex-culturally-targeted-intervention-to-reduce-hispanic-disparities-in-living-kidney-donor-transplantation-an-effectiveness-implementation-hybrid-study-protocol
#11
Elisa J Gordon, Jungwha Lee, Raymond H Kang, Juan Carlos Caicedo, Jane L Holl, Daniela P Ladner, Michelle D Shumate
BACKGROUND: The shortage of organs for kidney transplantation for patients with end-stage renal disease (ESRD) is magnified in Hispanics/Latin Americans in the United States. Living donor kidney transplantation (LDKT) is the treatment of choice for ESRD. However, compared to their representation on the transplant waitlist, fewer Hispanics receive a LDKT than non-Hispanic whites. Barriers to LDKT for Hispanics include: lack of knowledge, cultural concerns, and language barriers. Few interventions have been designed to reduce LDKT disparities...
May 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29768477/faster-clinical-response-to-the-onset-of-adverse-events-a-wearable-metacognitive-attention-aid-for-nurse-triage-of-clinical-alarms
#12
Daniel C McFarlane, Alexa K Doig, James A Agutter, Lara M Brewer, Noah D Syroid, Ranjeev Mittu
OBJECTIVE: This study evaluates the potential for improving patient safety by introducing a metacognitive attention aid that enables clinicians to more easily access and use existing alarm/alert information. It is hypothesized that this introduction will enable clinicians to easily triage alarm/alert events and quickly recognize emergent opportunities to adapt care delivery. The resulting faster response to clinically important alarms/alerts has the potential to prevent adverse events and reduce healthcare costs...
2018: PloS One
https://www.readbyqxmd.com/read/29766307/the-laparoscopic-inguinal-and-diaphragmatic-defect-lidd-model-a-validation-study-of-a-novel-box-trainer-model
#13
Damir Ljuhar, Samuel Alexander, Sarah Martin, Ramesh Nataraja
BACKGROUND: Paediatric laparoscopic procedures are now becoming routine practice. Therefore, there is a need for simulated laparoscopic models to acquire part-procedural competency prior to direct patient contact in a safe learning environment. For this reason, we chose two paediatric conditions; inguinal hernia (IH) and congenital diaphragmatic hernia (CDH), which were combined to create the laparoscopic inguinal and diaphragmatic defect (LIDD) model. Our aim was to assess this novel surgical simulation model by determining its construct and content validity...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29765941/nano-and-micro-patterned-s-h-and-x-pdms-for-cell-based-applications-comparison-of-wettability-roughness-and-cell-derived-parameters
#14
Marina Scharin-Mehlmann, Aaron Häring, Mathias Rommel, Tobias Dirnecker, Oliver Friedrich, Lothar Frey, Daniel F Gilbert
Polydimethylsiloxane (PDMS) is a promising biomaterial for generating artificial extracellular matrix (ECM) like patterned topographies, yet its hydrophobic nature limits its applicability to cell-based approaches. Although plasma treatment can enhance the wettability of PDMS, the surface is known to recover its hydrophobicity within a few hours after exposure to air. To investigate the capability of a novel PDMS-type (X-PDMS) for in vitro based assessment of physiological cell properties, we designed and fabricated plane as well as nano- and micrometer-scaled pillar-patterned growth substrates using the elastomer types S-, H- and X-PDMS, which were fabricated from commercially available components...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29764988/you-ve-made-the-diagnosis-of-functional-neurological-disorder-now-what
#15
EDITORIAL
Caitlin Adams, Jordan Anderson, Elizabeth N Madva, W Curt LaFrance, David L Perez
Patients with functional neurological disorders (FND)/conversion disorder commonly present to outpatient clinics. FND is now a 'rule in' diagnosis based on neurological examination findings and semiological features. While neurologists may be more comfortable diagnosing patients with FND, there is only limited guidance as to how to conduct follow-up outpatient visits. Using clinical vignettes, we provide practical suggestions that may help guide clinical encounters including how to: (1) explore illness beliefs openly; (2) enquire longitudinally about predisposing vulnerabilities, acute precipitants and perpetuating factors that may be further elucidated over time; (3) facilitate psychotherapy engagement by actively listening for potentially unhelpful or maladaptive patterns of thoughts, behaviours, fears or psychosocial stressors that can be reflected back to the patient and (4) enquire about the fidelity of individual treatments and educate other providers who may be less familiar with FND...
May 15, 2018: Practical Neurology
https://www.readbyqxmd.com/read/29762597/universal-holonomic-single-quantum-gates-over-a-geometric-spin-with-phase-modulated-polarized-light
#16
Naoki Ishida, Takaaki Nakamura, Touta Tanaka, Shota Mishima, Hiroki Kano, Ryota Kuroiwa, Yuhei Sekiguchi, Hideo Kosaka
We demonstrate universal non-adiabatic non-abelian holonomic single quantum gates over a geometric electron spin with phase-modulated polarized light and 93% average fidelity. This allows purely geometric rotation around an arbitrary axis by any angle defined by light polarization and phase using a degenerate three-level Λ-type system in a negatively charged nitrogen-vacancy center in diamond. Since the control light is completely resonant to the ancillary excited state, the demonstrated holonomic gate not only is fast with low power, but also is precise without the dynamical phase being subject to control error and environmental noise...
May 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29762137/spatial-frequency-performance-limitations-of-radiation-dose-optimization-and-beam-positioning
#17
James M P Stewart, Shawn Stapleton, Naz Chaudary, Patricia E Lindsay, David A Jaffray
The flexibility and sophistication of modern radiotherapy treatment planning and delivery methods have advanced techniques to improve the therapeutic ratio. Contemporary dose optimization and calculation algorithms facilitate radiotherapy plans which closely conform the three-dimensional dose distribution to the target, with beam shaping devices and image guided field targeting ensuring the fidelity and accuracy of treatment delivery. Ultimately, dose distribution conformity is limited by the maximum deliverable dose gradient; shallow dose gradients challenge techniques to deliver a tumoricidal radiation dose while minimizing dose to surrounding tissue...
May 15, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29761064/development-of-a-site-fidelity-index-based-on-population-capture-recapture-data
#18
Ayelen Tschopp, Mariano A Ferrari, Enrique A Crespo, Mariano A Coscarella
Background: Site fidelity is considered as an animal's tendency to return to a previously occupied place; this is a component of animal behaviour that allows us to understand movement patterns and aspects related to the animal's life history. Although there are many site fidelity metrics, the lack of standardisation presents a considerable challenge in terms of comparability among studies. Methods: This investigation focused on the theoretical development of a standardised composite site fidelity index and its statistical distribution in order to obtain reliable population-level site fidelity comparisons...
2018: PeerJ
https://www.readbyqxmd.com/read/29760890/diel-movement-of-brown-trout-salmo-trutta-is-reduced-in-dense-populations-with-high-site-fidelity
#19
Ondřej Slavík, Pavel Horký, Matúš Maciak, Petra Horká, Iva Langrová
The movement of individuals within preferred areas is reduced by a high availability of food and information about its distribution, while high number of competitors promotes increased movement. Experienced animals use information about social and physical environment to improve resources exploitation, tended to maintain positions within the preferred areas and reuse the environment that is often referred to as site fidelity. In this study, radio-telemetry was used to observe the movements of 98 adult brown trout, Salmo trutta , in oligotrophic streams with different population densities; to determine subpopulation site fidelity, 5,195 conspecifics from 14 subpopulations were individually tagged during spring and autumn...
May 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29760218/validation-of-an-expanded-carrier-screen-that-optimizes-sensitivity-via-full-exon-sequencing-and-panel-wide-copy-number-variant-identification
#20
Gregory J Hogan, Valentina S Vysotskaia, Kyle A Beauchamp, Stefanie Seisenberger, Peter V Grauman, Kevin R Haas, Sun Hae Hong, Diana Jeon, Shera Kash, Henry H Lai, Laura M Melroy, Mark R Theilmann, Clement S Chu, Kevin Iori, Jared R Maguire, Eric A Evans, Imran S Haque, Rebecca Mar-Heyming, Hyunseok P Kang, Dale Muzzey
BACKGROUND: By identifying pathogenic variants across hundreds of genes, expanded carrier screening (ECS) enables prospective parents to assess the risk of transmitting an autosomal recessive or X-linked condition. Detection of at-risk couples depends on the number of conditions tested, the prevalence of the respective diseases, and the screen's analytical sensitivity for identifying disease-causing variants. Disease-level analytical sensitivity is often <100% in ECS tests because copy number variants (CNVs) are typically not interrogated because of their technical complexity...
May 14, 2018: Clinical Chemistry
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