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catheter prednisone

Shuichiro Takashima, Tetsuya Eto, Motoaki Shiratsuchi, Michihiro Hidaka, Yasuo Mori, Koji Kato, Kenjiro Kamezaki, Seido Oku, Hideho Henzan, Ken Takase, Takamitsu Matsushima, Katsuto Takenaka, Hiromi Iwasaki, Toshihiro Miyamoto, Koichi Akashi, Takanori Teshima
OBJECTIVE: We examined the therapeutic strategies for treating mild gastrointestinal (GI) graft-versus-host disease (GVHD) using oral beclomethasone dipropionate (BDP) in 15 Japanese patients based on the donor source. The primary objective was to determine the efficacy and toxicity of oral BDP combined with/without low-dose prednisone (PSL). METHODS: Oral BDP was administered with 1 mg/kg/d of PSL in patients undergoing bone marrow transplantation (BMT) or peripheral blood stem cell transplantation (PBSCT; n=11), and the dose of PSL was tapered off after 22 days...
2014: Internal Medicine
Kenneth J Woodside, Zachary W Schirm, Kelly A Noon, Anne M Huml, Aparna Padiyar, Edmund Q Sanchez, Nagaraju Sarabu, Donald E Hricik, James A Schulak, Joshua J Augustine
BACKGROUND: Patients returning to dialysis therapy after renal transplant failure have high morbidity and retransplant rates. After observing frequent hospitalizations with fever after failure, it was hypothesized that maintaining immunosuppression for the failed allograft increases the risk of infection, while weaning immunosuppression can lead to symptomatic rejection mimicking infection. METHODS: One hundred eighty-six patients with failed kidney transplants were analyzed for rates of hospitalization with fever within 6 months of allograft failure...
March 27, 2014: Transplantation
Kenneth J Woodside, Zachary W Schirm, Kelly A Noon, Anne M Huml, Aparna Padiyar, Edmund Q Sanchez, Nagaraju Sarabu, Donald E Hricik, James A Schulak, Joshua J Augustine
BACKGROUND: Patients returning to dialysis therapy after renal transplant failure have high morbidity and retransplant rates. After observing frequent hospitalizations with fever after failure, it was hypothesized that maintaining immunosuppression for the failed allograft increases the risk of infection, while weaning immunosuppression can lead to symptomatic rejection mimicking infection. METHODS: One hundred eighty-six patients with failed kidney transplants were analyzed for rates of hospitalization with fever within 6 months of allograft failure...
November 19, 2013: Transplantation
L G Chicoine, C L Montgomery, W G Bremer, K M Shontz, D A Griffin, K N Heller, S Lewis, V Malik, W E Grose, C J Shilling, K J Campbell, T J Preston, B D Coley, P T Martin, C M Walker, K R Clark, Z Sahenk, J R Mendell, L R Rodino-Klapac
Duchenne muscular dystrophy is a monogenic disease potentially treatable by gene replacement. Use of recombinant adeno-associated virus (AAV) will ultimately require a vascular approach to broadly transduce muscle cells. We tested the impact of preexisting AAV antibodies on microdystrophin expression following vascular delivery to nonhuman primates. Rhesus macaques were treated by isolated limb perfusion using a fluoroscopically guided catheter. In addition to serostatus stratification, the animals were placed into one of the three immune suppression groups: no immune suppression, prednisone, and triple immune suppression (prednisone, tacrolimus, and mycophenolate mofetil)...
February 2014: Molecular Therapy: the Journal of the American Society of Gene Therapy
M Ussowicz, J Musiał, M Mielcarek, A Tomaszewska, B Nasiłowska-Adamska, K Kałwak, E Gorczyńska, B Mariańska, A Chybicka
INTRODUCTION: Steroid-refractory graft-versus-host disease (GVHD) remains a challenging therapeutic problem after allogeneic hematopoietic stem cell transplantation (HSCT). The aim of this study was to evaluate the clinical effect of extracorporeal photopheresis (ECP), and its impact on intensivity of immunosuppresive therapy in allogeneic HSCT patients. PATIENTS AND METHODS: In this study 443 Therakos ECP procedures were performed in 21 patients after allogeneic HSCT with acute (aGVHD, 8 patients) or chronic (cGVHD, 13 patients) therapy-refractory GVHD...
November 2013: Transplantation Proceedings
Nadear Elmahi, Eva Csongrádi, Kenneth Kokko, Jack R Lewin, Jamie Davison, Tibor Fülöp
Immunosuppression (IS) is often withdrawn in patients with end stage renal disease secondary to a failed renal allograft, and this can lead to an accelerated loss of residual renal function (RRF). As maintenance of RRF appears to provide a survival benefit to peritoneal dialysis (PD) patients, it is not clear whether this benefit of maintaining RRF in failed allograft patients returning to PD outweigh the risks of maintaining IS. A 49 year-old Caucasian male developed progressive allograft failure nine years after living-donor renal transplantation...
June 24, 2013: World Journal of Transplantation
N F Davis, L C McLoughlin, C Dowling, R Power, P Mohan, D Hickey, G Smyth, M Eng, D M Little
OBJECTIVE: To review the incidence and long-term outcomes of squamous cell carcinoma (SCC) of the bladder in patients after kidney transplantation. METHODS: Between January 1976 and March 2013, five patients from one center (0.0013%) developed SCC of the bladder after undergoing a deceased donor kidney transplant. Their relevant risk factors included long-term self-intermittent catheterization/indwelling catheter (n = 2), smoking history (n = 2), and a prior history of cyclophosphamide treatment for vasculitis (n = 1)...
November 2013: Clinical Transplantation
Ian D Pavord, Neil C Thomson, Robert M Niven, Paul A Corris, Kian Fan Chung, Gerard Cox, Brian Armstrong, Narinder S Shargill, Michel Laviolette
BACKGROUND: Patients with severe refractory asthma treated with bronchial thermoplasty (BT), a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle, were followed up for 5 years to evaluate long-term safety of this procedure. OBJECTIVES: To assess long-term safety of BT for 5 years. METHODS: Patients with asthma aged 18 to 65 years requiring high-dose inhaled corticosteroids (ICSs) (>750 μg/d of fluticasone propionate or equivalent) and long-acting β2-agonists (LABAs) (at least 100 μg/d of salmeterol or equivalent), with or without oral prednisone (≤30 mg/d), leukotriene modifiers, theophylline, or other asthma controller medications were enrolled in the Research in Severe Asthma (RISA) Trial...
November 2013: Annals of Allergy, Asthma & Immunology
Petar Durić, Zdenka Majster, Verica Stanković Popović, Vesna Maslarević Radović, Nada Dimković
INTRODUCTION: Encapsulating peritoneal sclerosis is a possible, serious, life-threatening complication of peritoneal dialysis therapy. CASE 1: A female patient was hospitalized for clinical signs of encapsulating peritoneal sclerosis in the inflammatory stage with fever, intestinal occlusion, positive inflammatory syndrome (Le 20 K/microL,.CRP 217 mg/L) and highly turbid peritoneal effluent (Le 3.3 K/microL) with sterile culture. Risk factors for the development of encapsulating peritoneal sclerosis were nine previous episodes of peritonitis and long-term use of high osmolality dialysis solution...
March 2013: Medicinski Pregled
Jean-François Augusto, Johnny Sayegh, Laurence Delapierre, Anne Croue, Fréderic Tollis, Maud Cousin, Jean-François Subra
BACKGROUND: Adult Henoch-Schönlein purpura (HSP) has been associated with poor outcome and end-stage renal disease in >20% of cases. Although the benefit of adding another immunosuppressant to steroids in severe adult HSP has not been shown, the benefit of plasma exchange (PE) therapy has been poorly evaluated. STUDY DESIGN: Case series. SETTING & PARTICIPANTS: 11 consecutive patients with severe and newly diagnosed HSP since 1988 who were treated with steroids and PE...
May 2012: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Elerson Arfelli, Sérgio de Araujo, Mieko Okada, Thais Nascimento, Luis Felipe N dos Santos, Marcello Franco, Angelo A V de Paola, Guilherme Fenelon
AIMS: Corticosteroids attenuate late growth of radiofrequency (RF) lesions in the thigh muscle of infant rats. We sought to assess the impact of these drugs on the late growth of RF lesions in immature swine myocardium and to determine the electroanatomical mapping (EAM) characteristics of these lesions. METHODS AND RESULTS: Radiofrequency (60°C; 60 s) lesions were created in the right atrium (n = 2) and ventricle (n = 2) of 14 piglets (age 65 days; weight 5 kg) and 3 adults...
January 2011: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Takeshi Hara, Hisashi Tsurumi, Senji Kasahara, Kengo Ogawa, Jun Takada, Kenji Imai, Koji Takai, Jun-ichi Kitagawa, Shigeru Kiyama, Naoki Imai, Masami Oyama, Tsuyoshi Takami, Hisataka Moriwaki
A 48-year-old woman was admitted to our hospital in 2003, complaining of weight loss. Complete blood cell count revealed thrombocytopenia. Abdominal CT demonstrated marked splenomegaly. FDG-PET revealed a hot spot in the whole spleen. A splenectomy was performed. Histological examination was typical for angiosarcoma. Adjuvant chemotherapy was given, and high-dose chemotherapy with autologous peripheral blood stem cell transplantation was performed. Thrombocytopenia developed again in 2008. CT scan showed a hepatic tumor...
2010: Internal Medicine
Maroun M Abou-Jaoude, Naji Nawfal, Joseph Shaheen, Ziad Daoud, Wassim Y Almawi
OBJECTIVES: Infections remain a frequent, potentially life-threatening complication of kidney transplant. SUBJECTS AND METHODS: Between 1998 and 2006, we evaluated the incidence of infections in 114 kidney transplant patients, with a 1-year follow-up. All patients received a posttransplant anti-infectious prophylaxis regimen. Induction therapy was given to 94 patients (82.4%), and maintenance immunosuppression consisted of calcineurin inhibitor (cyclosporin microemulsion or tacrolimus), together with mycophenolate mofetil and prednisone...
June 2010: Experimental and Clinical Transplantation
Seda Oztürkmen, Ayşenur Paç, Atilla Senayl, Tuğçin Bora Polat, Ibrahim Ilker Cetin, Zafer Bçakç, Arzu Akyay, Lale Olcay
A 4-year-old boy with acute lymphoblastic leukemia (ALL) was inserted a central venous catheter into right vena jugularis interna, whereas on BFM-ALL (Protocol 1) therapy. He developed progressive anemia, thrombocytopenia, schistocytes with triangular or crescent shapes, microspherocytes and teardrop cells in the peripheric blood smear, elevated lactate dehydrogenase, and decreased haptoglobin. Schistocytic hemolytic anemia was considered. On chest radiogram, the central venous catheter (CVC) tip was seen beneath the expected location...
August 2010: Journal of Pediatric Hematology/oncology
A Rodríguez Jornet, F J Andreu Navarro, R Orellana Fernández, J Ibeas López, M García García
Idiopathic retroperitoneal fibrosis is a rare disease often causing obstructive uropathy because the fibrosis entraps the ureters. The retroperitoneal tissue is constituted by a fibrous component and a chronic inflammatory infiltrate with the former characterized by miofibroblasts. The infiltrate displayed perivascular. Last years, the immunosuppressive therapy and the decompression of obstructive renal failure have improved the prognostic. We reported 9 patients with Idiopathic retroperitoneal fibrosis in a Centre...
2009: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Cihan Cevik, Troy Wilborn, Rita Corona, Elizabeth Schanzmeyer, Kenneth Nugent
Post-cardiac injury syndrome is an inflammatory process involving the pleura and pericardium secondary to cardiac injury and can develop following transvenous pacemaker insertion. We now report a patient who developed this syndrome following dual-chamber pacemaker insertion with active fixation of the atrial and ventricular leads. The pericardial fluid was bloody and had a neutrophilic predominance. The pericardial biopsy revealed fibrinous pericarditis with a mixed inflammatory cell infiltrate. The pleural effusion was exudative and had a neutrophilic predominance...
December 2009: Heart, Lung & Circulation
F Jghaimi, A Kabbaj, L Essaadouni
The authors report a 38-year-old young Moroccan woman with retroperitoneal fibrosis (RPF) associated with Takayasu's disease. The RPF was diagnosed in the presence of an acute renal failure requiring placement of double J catheters while an abdominal CT scan was suggestive of RPF. The diagnosis of Takayasu's disease was suspected three years later when the patient presented with right upper extremity dysesthesia. Aortic angiography showed evidence of typical inflammatory arteritis involvement with bilateral regular and concentric stenosis of axillary arteries and a left, smoothly narrowed primitive carotid artery, and left renal artery partial occlusion...
March 2010: La Revue de Médecine Interne
T Urban
Supportive care is the total medical, nursing and psychosocial help which the patients need besides the specific treatment. Supportive care leads to reduce morbidity and toxicity of the disease and cancer therapy, and require an optimal medical organisation. Reduction of toxicity with lung cancer chemotherapy often requires premedication such as prednisone, or vitamins or hydration for cisplatin use. An evidence-based approach to central venous catheter management leads to prevent catheter-related infection or thrombosis...
October 2008: Revue des Maladies Respiratoires
S Adler, S Lodermeyer, J Gaa, U Heemann
OBJECTIVE: To assess the therapeutic benefit of mycophenolate mofetil (MMF) in retroperitoneal fibrosis (RF). METHODS: MMF 2 g/day and prednisone 1 mg/kg were initiated in nine patients with radiological (9/9) and histological verification (2/9) of idiopathic RF. Out of nine patients, seven needed bilateral ureteral stenting due to extensive hydronephrosis. RESULTS: All patients experienced regression of radiological extension. Out of seven patients, five were free of ureteral catheters after a mean of 5...
October 2008: Rheumatology
Guilherme Fenelon, Thais Nascimento, Sérgio DE Araújo, Mieko Okada, Marcello Franco, Angelo A V DE Paola
BACKGROUND: We explored the angiographic and pathological effects of corticosteroids on the long-term outcome of radiofrequency (RF) ablation lesions in the swine caval veins. METHODS: Under fluoroscopy guidance, a single linear RF lesion (4-mm tip, 60 degrees C, 180 seconds) was created in each vena cava (from +/-2 cm into the vein to the venoatrial junction) of 20 anesthetized minipigs (35+/- 2 kg). Three groups were studied: acute (n = 4), killed 1 hour after RF; control (n = 8), sacrificed 83+/- 1 days after RF; and pigs (n = 8) receiving hydrocortisone (400 mg i...
August 2008: Pacing and Clinical Electrophysiology: PACE
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