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Endometrial immunology

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https://www.readbyqxmd.com/read/29553138/interferon-%C3%AE-induced-in-female-genital-epithelium-by-hiv-1-glycoprotein-120-via-toll-like-receptor-2-pathway-acts-to-protect-the-mucosal-barrier
#1
Aisha Nazli, Sara Dizzell, Muhammad Atif Zahoor, Victor H Ferreira, Jessica Kafka, Matthew William Woods, Michel Ouellet, Ali A Ashkar, Michel J Tremblay, Dawn Me Bowdish, Charu Kaushic
More than 40% of HIV infections occur via female reproductive tract (FRT) through heterosexual transmission. Epithelial cells that line the female genital mucosa are the first line of defense against HIV-1 and other sexually transmitted pathogens. These sentient cells recognize and respond to external stimuli by induction of a range of carefully balanced innate immune responses. Previously, we have shown that in response to HIV-1 gp120, the genital epithelial cells (GECs) from upper reproductive tract induce an inflammatory response that may facilitate HIV-1 translocation and infection...
March 19, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29506962/immunology-of-endometriosis
#2
REVIEW
Luiza da Gama Coelho Riccio, Pietro Santulli, Louis Marcellin, Mauricio Simões Abrão, Frederic Batteux, Charles Chapron
The pathophysiology of endometriosis is not completely understood, but an aberrant immune response in the peritoneal environment seems to be crucial for the proliferation of ectopic endometrial cells - as those cells escape apoptosis and peritoneal cavity immunosurveillance. The growth of endometrial implants leads to the recruitment of a large number and diversity of immune cells and intense inflammation with increased pro-inflammatory cytokines, growth factors, and angiogenesis. There is substantial evidence of aberrant function of almost all types of immune cells in women with endometriosis: decreased T cell reactivity and NK cytotoxicity, polyclonal activation of B cells and increased antibody production, increased number and activation of peritoneal macrophages, and changes in inflammatory mediators...
February 8, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29460338/mdscs-drive-the-process-of-endometriosis-by-enhancing-angiogenesis-and-are-a-new-potential-therapeutic-target
#3
Tao Zhang, Juhua Zhou, Gene Chi Wai Man, Kam Tong Leung, Bo Liang, Bo Xiao, Xinting Ma, Shaoyan Huang, Huaxiang Huang, Venkatesh L Hegde, Yin Zhong, Yanmin Li, Grace Wing Shan Kong, Alice KaWah Yiu, Joseph Kwong, Pak Cheung Ng, Prakash S Nagarkatti, Mitzi Nagarkatti, Chi Chiu Wang
Endometriosis affects women of reproductive age via unclear immunological mechanism(s). Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of myeloid cells with potent immunosuppressive and angiogenic properties. Here we found MDSCs significantly increased in the peripheral blood of patients with endometriosis and in the peritoneal cavity of a mouse model of surgically-induced endometriosis. Majority of MDSCs were granulocytic, produced ROS and arginase, and suppressed T cell proliferation. Depletion of MDSCs by antiGr-1 antibody dramatically suppressed development of endometrial lesions in mice...
February 20, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29456541/ifn-%C3%AF-mediated-control-of-bovine-major-histocompatibility-complex-class-i-expression-and-function-via-the-regulation-of-bta-mir-148b-152-in-bovine-endometrial-epithelial-cells
#4
Haichong Wu, Kangfeng Jiang, Shuai Guo, Jing Yang, Gan Zhao, Changwei Qiu, Ganzhen Deng
IFN-τ, a type I interferon produced by the trophoblasts of ruminants, has various important immune functions, including effects on the expression of major histocompatibility complex (MHC) class I (MHC-I). A previous study has reported that IFN-τ promotes the expression of MHC-I molecules on endometrial cells. However, the immunological mechanisms by which IFN-τ regulates MHC-I molecules remain unknown. Here, we investigated which microRNA (miRNAs) may be involved in the regulation of MHC-I molecule expression and function in bovine endometrial epithelial cells (bEECs)...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29315421/development-of-a-new-comprehensive-and-reliable-endometrial-receptivity-map-er-map-er-grade-based-on-rt-qpcr-gene-expression-analysis
#5
M Enciso, J P Carrascosa, J Sarasa, P A Martínez-Ortiz, S Munné, J A Horcajadas, J Aizpurua
STUDY QUESTION: Is it possible to determine the receptivity status of an endometrium by combined quantitative reverse transcription PCR (RT-qPCR) expression analysis of genes involved in endometrial proliferation and immunity? SUMMARY ANSWER: The new ER Map®/ER Grade® test can predict endometrial receptivity status by RT-qPCR using a new panel of genes involved in endometrial proliferation and the maternal immune response associated to embryonic implantation. WHAT IS KNOWN ALREADY: The human endometrium reaches a receptive status adequate for embryonic implantation around Days 19-21 of the menstrual cycle...
February 1, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29092787/estradiol-metabolites-as-biomarkers-of-endometrial-cancer-prognosis-after-surgery
#6
Yannick Audet-Delage, Jean Grégoire, Patrick Caron, Véronique Turcotte, Marie Plante, Pierre Ayotte, David Simonyan, Lyne Villeneuve, Chantal Guillemette
Endometrial cancer (EC) is the most common gynecologic malignancy prevailing after menopause. Defining steroid profiles may help predict the risk of recurrence after hysterectomy, which remains limited due to the lack of reliable markers. Adrenal precursors, androgens, parent estrogens and catechol estrogen metabolites were measured by mass spectrometry (MS) in preoperative serums and those collected one month after hysterectomy from 246 newly diagnosed postmenopausal EC cases. We also examined the associations between steroid hormones and EC status by including 110 healthy postmenopausal women...
April 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29020784/-screening-of-endometrial-nk-cells-in-selected-infertile-patients-first-part-methods-and-current-results
#7
Z Ulčová-Gallová, M Pešek, P Chaloupka, P Mukešnábl, M Haschová, P Losan, K Bibková, Z Mičanová, J Cibulka
INTRODUCTION: Generaly, natural killer cells (NK cells) are among the most important cells of our immune defense system. They are present in the blood, decidua but also in secretory endometrium. OBJECTIVE: We investigate an association between high density of NK cells CD56+ and NK cells CD16+ into blood and secretory endometrium in patients with up to now unexplained recurrent miscarriage. At the same time, we focused on diagnosis of antiphospholipid syndrome, congenital trombophilic factors, stress factor, and lenght of hormonal contraception before conception...
2017: Ceská Gynekologie
https://www.readbyqxmd.com/read/28977879/specific-microrna-library-of-ifn-%C3%AF-on-bovine-endometrial-epithelial-cells
#8
Haichong Wu, Tao Zhang, Xiaofei Ma, Kangfeng Jiang, Gan Zhao, Changwei Qiu, Ganzhen Deng
IFN-τ is specifically secreted by the conceptus in ruminants during early pregnancy, and it plays a vital role in the immunological function of pregnancy. However, its mechanism involving microRNA (miRNA) is still not well understood. Deep sequencing was used to explore the specific miRNA library of IFN-τ on bovine endometrial epithelial cells (bEECs). The results showed that 574 known bovine miRNAs and 109 novel miRNAs were identified. We found 74 differentially expressed miRNAs, including 30 commonly expressed miRNAs in the experiment...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28803166/advanced-age-in-mares-affects-endometrial-secretion-of-arachidonic-acid-metabolites-during-equine-subclinical-endometritis
#9
Marta J Siemieniuch, Katarzyna Gajos, Roland Kozdrowski, Marcin Nowak
Even if mares continue to breed up to an advanced age, in aging mares reproductive failure is quite common. Subclinical endometritis, which occurs more often in aging mares than in younger counterparts, may cause prolongation or shortening of the inter-estrus period or the corpus luteum lifespan. We hypothesized that during subclinical endometritis the secretion of selected arachidonic acid metabolites may differ in aging mares compared to younger females. To verify this thesis, ex vivo organ cultures of endometrium were established with subsequent measurements of concentrations of prostaglandin E2 (PGE2), 6-keto-PGF1α and both leukotrienes (LTs), LTB4 and LTC4 in the culture supernatants...
November 2017: Theriogenology
https://www.readbyqxmd.com/read/28735887/effect-of-pyrethroids-on-female-genital-system-review
#10
REVIEW
Elena Marettova, Milan Maretta, Jaroslav Legáth
Pyrethroids have been associated with a range of toxicological effects on various organs in animals.Recent animal studies suggest that neurodevelopmental, reproductive, and immunological effects may result following exposure to some pyrethroids at levels below those that induce overt signs of neurotoxicity. A variety of pyrethroids and their metabolites have the potential to affect the reproductive system. Dose-dependent effects on reproduction are associated with exposure across pyrethroid types. In mammals, permethrin and tetramethrin and cypermethrin have been found to be associated with adverse effects at high doses...
July 16, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28681517/increased-expression-of-resistin-in-ectopic-endometrial-tissue-of-women-with-endometriosis
#11
Yoon Kyung Oh, Young Ran Ha, Kyong Wook Yi, Hyun Tae Park, Jung-Ho Shin, Tak Kim, Jun-Young Hur
PROBLEM: Inflammation is a key process in the establishment and progression of endometriosis. Resistin, an adipocytokine, has biological properties linked to immunologic functions, but its role in endometriosis is unclear. METHOD OF STUDY: Resistin gene expression was examined in eutopic and ectopic endometrial tissues from women with (n=25) or without (n=25) endometriosis. Resistin mRNA and protein levels were determined in endometrial tissue using quantitative real-time reverse transcription PCR and Western blotting, following adipokine profiling arrays...
July 6, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28654900/specific-microrna-library-of-ifn-%C3%AF-on-bovine-endometrial-epithelial-cells
#12
Haichong Wu, Tao Zhang, Xiaofei Ma, Kangfeng Jiang, Gan Zhao, Changwei Qiu, Ganzhen Deng
IFN-τ is specifically secreted by the conceptus in ruminants during early pregnancy, and it plays a vital role in the immunological function of pregnancy. However, its mechanism involving microRNA (miRNA) is still not well understood. Deep sequencing was used to explore the specific miRNA library of IFN-τ on bovine endometrial epithelial cells (bEECs). The results showed that 574 known bovine miRNAs and 109 novel miRNAs were identified. We found 74 differentially expressed miRNAs, including 30 commonly expressed miRNAs in the experiment...
June 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/28571791/unus-pro-omnibus-omnes-pro-uno-a-novel-evidence-based-unifying-theory-for-the-pathogenesis-of-endometriosis
#13
Antonio Simone Laganà, Salvatore Giovanni Vitale, Francesca Maria Salmeri, Onofrio Triolo, Helena Ban Frangež, Eda Vrtačnik-Bokal, Lily Stojanovska, Vasso Apostolopoulos, Roberta Granese, Vincenza Sofo
The theory of retrograde menstruation as aetiopathogenesis of endometriosis formulated by John Sampson in 1927 shows clear shortcomings: this does not explain why retrograde menstruation is a physiological process that affects 90% of women, while endometriosis occurs in only 10% of cases; it also does not explain the endometriotic foci distant from the pelvis, nor explains the cases of endometriosis in male patients. The immunological alterations of the peritoneal fluid explains the effects of disease, such as the inhibition of the physiological processes of cytolysis, but does not explain the cause...
June 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28523429/kir-lilrb-and-their-ligands-genes-as-potential-biomarkers-in-recurrent-implantation-failure
#14
REVIEW
Izabela Nowak, Karolina Wilczyńska, Jacek R Wilczyński, Andrzej Malinowski, Paweł Radwan, Michał Radwan, Piotr Kuśnierczyk
Reproductive failure in humans is a very important social and economic problem, because nowadays women decide to conceive later in life and delay motherhood. Unfortunately, with increasing age they have less chance for natural fertilization and maintenance of pregnancy. Many of them need assisted reproductive technology. Approximately 10% of women after in vitro fertilization-embryo transfers experience recurrent implantation failure (RIF). Multiple factors may contribute to RIF, including oocyte and sperm quality, parental chromosomal anomalies, genetic or metabolic abnormalities of the embryo, poor uterine receptivity, immunological disturbances in the implantation site, and some gynecologic pathologies such as endometriosis, uterine fibroids, hydrosalpinx and endometrial polyps...
October 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28501364/immune-modulation-treatments-where-is-the-evidence
#15
REVIEW
Malene Meisner Hviid, Nick Macklon
While advances in assisted reproductive techniques have been substantial, failure of the apparently viable embryo to implant remains a source of distress and frustration to patients and specialists alike. The unique maternal immunological response to the embryo and the notion that defects in early placentation underlie the great complications of pregnancy have focused attention on the therapeutic potential of peri-implantation immunomodulation. On the face of it, the rationale for this approach is very attractive...
June 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28476234/clinical-implications-for-germline-pten-spectrum-disorders
#16
REVIEW
Joanne Ngeow, Kaitlin Sesock, Charis Eng
Patients with PTEN hamartoma tumor syndrome (PHTS) may present to a variety of different subspecialties with benign and malignant clinical features. They have increased lifetime risks of breast, endometrial, thyroid, renal, and colon cancers, as well as neurodevelopmental disorders such as autism spectrum disorder. Patients and affected family members can be offered gene-directed surveillance and management. Patients who are unaffected can be spared unnecessary investigations. With longitudinal follow-up, we are likely to identify other non-cancer manifestations associated with PHTS such as metabolic, immunologic, and neurologic features...
June 2017: Endocrinology and Metabolism Clinics of North America
https://www.readbyqxmd.com/read/28344870/immunological-profiling-of-molecularly-classified-high-risk-endometrial-cancers-identifies-pole-mutant-and-microsatellite-unstable-carcinomas-as-candidates-for-checkpoint-inhibition
#17
Florine A Eggink, Inge C Van Gool, Alexandra Leary, Pamela M Pollock, Emma J Crosbie, Linda Mileshkin, Ekaterina S Jordanova, Julien Adam, Luke Freeman-Mills, David N Church, Carien L Creutzberg, Marco De Bruyn, Hans W Nijman, Tjalling Bosse
High-risk endometrial cancer (EC) is an aggressive disease for which new therapeutic options are needed. Aims of this study were to validate the enhanced immune response in highly mutated ECs and to explore immune profiles in other EC subgroups. We evaluated immune infiltration in 116 high-risk ECs from the TransPORTEC consortium, previously classified into four molecular subtypes: (i) ultramutated POLE exonuclease domain-mutant ECs (POLE-mutant); (ii) hypermutated microsatellite unstable (MSI); (iii) p53-mutant; and (iv) no specific molecular profile (NSMP)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28271702/update-on-endometriosis-pathogenesis
#18
Adam Czyzyk, Agnieszka Podfigurna, Anna Szeliga, Blazej Meczekalski
Endometriosis is a chronic, inflammatory, condition of high incidence and serious reproductive and general health consequences. Understanding the pathogenesis of endometriosis is crucial for proper diagnostic and ordering the most effective treatment. Even though there is a large body of data regarding this pathology our understanding of the pathogenesis of this disease remains incomplete. The aim of this review is to summarize contemporary data regarding pathogenesis of endometriosis. Current data regarding endometrial origin, metaplastic and Mullerian embryonic rests theory will be reviewed here...
March 7, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28271701/an-update-on-the-biological-markers-of-endometriosis
#19
Razvan Socolov, Demetra Socolov, Allia Sindilar, Ioana Pavaleanu
BACKGROUND: Endometriosis is a disease that affects 7-10% of reproductive-age women. When its diagnosis is delayed, its management becomes more difficult. Both for earlier detection and for therapeutic follow-up, discovering noninvasive biological markers with good specificity for this disease is a promising aspect of its research. We analyzed the recent data in the literature regarding these markers to determine which were worth following. MATERIALS AND METHODS: This literature review focused on medical data reported in the last 6 years (2011-2016)...
March 7, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28251956/-comparison-of-the-expression-profile-of-surface-molecular-markers-on-mesenchymal-stromal-cell-cultures-isolated-from-human-endometrium-and-umbilical-cord
#20
COMPARATIVE STUDY
A Yu Lupatov, R Yu Saryglar, V D Chuprynin, S V Pavlovich, K N Yarygin
Endometrial mesenchymal stromal cells (eMSCs), along with mesenchymal stromal cells (MSCs) isolated from other tissues, are promising for use in regenerative medicine. The benefits of eMSCs include their presence in adults, simplicity of isolation, high proliferative and differentiation capacity. In this study, we have employed the flow cytometry technique to assess expression of 28 molecular markers on the surface of two eMSCs cultures. The culture of MSCs isolated from Wharton's jelly of the umbilical cord (uMSCs) was used as a reference, because uMSCs were studied in details earlier and demonstrated their effectiveness in vivo...
January 2017: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
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