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Endometrial immunology

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https://www.readbyqxmd.com/read/28112260/an-altered-endometrial-cd8-tissue-resident-memory-t-cell-population-in-recurrent-miscarriage
#1
J H Southcombe, G Mounce, K McGee, A Elghajiji, J Brosens, S Quenby, T Child, I Granne
When trying to conceive 1% of couples have recurrent miscarriages, defined as three or more consecutive pregnancy losses. This is not accounted for by the known incidence of chromosomal aneuploidy in miscarriage, and it has been suggested that there is an immunological aetiology. The endometrial mucosa is populated by a variety of immune cells which in addition to providing host pathogen immunity must facilitate pregnancy. Here we characterise the endometrial CD8-T cell population during the embryonic window of implantation and find that the majority of cells are tissue resident memory T cells with high levels of CD69 and CD103 expression, proteins that prevent cells egress...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28108942/compartmentalized-culture-of-perivascular-stroma-and-endothelial-cells-in-a-microfluidic-model-of-the-human-endometrium
#2
Juan S Gnecco, Virginia Pensabene, David J Li, Tianbing Ding, Elliot E Hui, Kaylon L Bruner-Tran, Kevin G Osteen
The endometrium is the inner lining of the uterus. Following specific cyclic hormonal stimulation, endometrial stromal fibroblasts (stroma) and vascular endothelial cells exhibit morphological and biochemical changes to support embryo implantation and regulate vascular function, respectively. Herein, we integrated a resin-based porous membrane in a dual chamber microfluidic device in polydimethylsiloxane that allows long term in vitro co-culture of human endometrial stromal and endothelial cells. This transparent, 2-μm porous membrane separates the two chambers, allows for the diffusion of small molecules and enables high resolution bright field and fluorescent imaging...
January 20, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28051087/effects-of-depot-medroxyprogesterone-acetate-on-the-immune-microenvironment-of-the-human-cervix-and-endometrium-implications-for-hiv-susceptibility
#3
K K Smith-McCune, J F Hilton, U Shanmugasundaram, J W Critchfield, R M Greenblatt, D Seidman, S Averbach, L C Giudice, B L Shacklett
Depot-medroxyprogesterone acetate is a commonly used injectable contraceptive that has been associated with an increased risk of HIV acquisition. This study compares effects of depot-medroxyprogesterone acetate on immune parameters from several upper reproductive tract compartments relevant to HIV-1 susceptibility in repetitive samples from 15 depot-medroxyprogesterone acetate users and 27 women not on hormonal contraceptives. Compared with samples from unexposed women in the mid-luteal phase, depot-medroxyprogesterone acetate use was associated with: increased endocervical concentrations of MCP1 and IFNalpha2; decreased endocervical concentrations of IL1beta and IL6; increased proportions of endometrial CD4+ and CD8+ cells expressing the activation marker HLADR; increased density of endometrial macrophages; and decreased density of endometrial regulatory T cells...
January 4, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/27915039/uterine-immune-profiling-for-increasing-live-birth-rate-a-one-to-one-matched-cohort-study
#4
Nathalie Lédée, Laura Prat-Ellenberg, Lucie Chevrier, Richard Balet, Cynthia Simon, Clarisse Lenoble, Elie El Irani, Dominique Bouret, Guy Cassuto, Dominique Vitoux, Katia Vezmar, Armand Bensussan, Gérard Chaouat, Marie Petitbarat
BACKGROUND: Embryo implantation remains the main limiting factor in IVF/ICSI program. Endometrial immune remodeling events begin before implantation and are a vital process for pregnancy, preparing future maternal immune tolerance and regulating the placentation process. METHODS: Between 2012 and 2014, 193 patients (analyzed group) enrolled in our IVF program benefitted of an endometrial immune profiling to determine if their uterus was immunologically ready to accept an embryo and, if not, the specific immune mechanisms involved...
November 24, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27865908/oleic-acid-promotes-the-expression-of-neural-markers-in-differentiated-human-endometrial-stem-cells
#5
Maryam Ali Mohammadie Kojour, Somayeh Ebrahimi-Barough, Homa Mohseni Kouchesfehani, Hanieh Jalali, Mohammah Hosein Karbalaie Ebrahim
Variety of neurodegenerative diseases in humans are caused by loss of cells along with loss of function and disability. Cell replacement therapy is a potential strategy to cure neurodegenerative diseases. Mesenchymal stem cells are pluripotent non-hematopoietic cells that can be isolated from numerous tissues. Human endometrial-derived stem cell (hEnSC) are the abundant and easy available source with no immunological response, for cell replacement therapy. In the nervous system, where fatty acids are found in huge amounts, they participate in its development and maintenance throughout life...
January 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/27852036/interim-analysis-of-a-phase-i-iia-trial-assessing-e39-gm-csf-a-folate-binding-protein-vaccine-to-prevent-recurrence-in-ovarian-and-endometrial-cancer-patients
#6
Doreen O Jackson, Kevin Byrd, Timothy J Vreeland, Diane F Hale, Garth S Herbert, Julia M Greene, Erika J Schneble, John S Berry, Alfred F Trappey, G T Clifton, Mark O Hardin, Jonathan Martin, John C Elkas, Thomas P Conrads, Kathleen M Darcy, Chad A Hamilton, George L Maxwell, George E Peoples
BACKGROUND: Folate binding protein(FBP) is an immunogenic protein over-expressed in endometrial(EC) and ovarian cancer(OC). We are conducting a phase I/IIa trial of E39 (GALE 301)+GM-CSF, an HLA-A2-restricted, FBP-derived peptide vaccine to prevent recurrences in disease-free EC and OC patients. This interim analysis summarizes toxicity, immunologic responses, and clinical outcomes to date. METHODS: HLA-A2+ patients were vaccinated(VG), and HLA-A2- or -A2+ patients were followed as controls(CG)...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27819791/-effectiveness-of-a-rapid-response-team-rrt-in-a-case-of-ruptured-ectopic-pregnancy
#7
José Miguel Campechano-López, María Lourdes Carranza-Bernal, Guillermina Juanico-Morales, María Rayo Reyes-Gil
BACKGROUND: An ectopic pregnancy happens when a fertilized egg attaches somewhere outside the endometrial surface. This sort of pregnancy has an estimated incidence of 1.6 to 2 each 100 births. The main objective was to expose the effective answer of a Rapid Response Team in a case of ruptured cervical ectopic pregnancy. We also describe a clinical case of this sort of pregnancy. CLINICAL CASE: 37-year-old female with a two-month history of amenorrhea. The patient entered the Labor & Delivery department with hypovolemic shock secondary to vaginal bleeding...
November 2016: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/27738175/oral-administration-of-pentoxifylline-reduces-endometriosis-like-lesions-in-a-nude-mouse-model
#8
Maria Perelló, Iñaki González-Foruria, Paola Castillo, Mario Martínez-Florensa, Francisco Lozano, Juan Balasch, Francisco Carmona
INTRODUCTION: Recent reports consider endometriosis to be an immunological disorder, thus suggesting potential efficacy of immunomodulators for its treatment. The aim of this study was to assess the effects of oral administration of pentoxifylline on endometriosis-like lesions in a heterologous mice model. STUDY DESIGN: Human endometrial tissue obtained from women (n = 5) undergoing surgery for benign conditions was implanted in nude female mice (n = 30). The animals were distributed into 3 experimental groups receiving: saline 0...
October 12, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27726474/augmented-angiogenic-factors-expression-via-fp-signaling-pathways-in-peritoneal-endometriosis
#9
Halima Rakhila, Mahera Al-Akoum, Charles Doillon, Nicolas Lacroix-Pépin, Mathieu Leboeuf, Madeleine Lemyre, Ali Akoum, Marc Pouliot
CONTEXT: Angiogenesis is required for ectopic endometrial tissue growth. Our previous studies showed that prostaglandin F2α (PGF2α) biosynthetic enzymes and receptor were markedly elevated in endometriotic lesions and that PGF2α is a potent angiogenic factor in endothelial cells. OBJECTIVE: We sought to determine whether or not the F-prostanoid receptor modulates angiogenesis in ectopic stromal cells. DESIGN: Release of angiogenic factors by ectopic endometrial stromal cell primary cultures stimulated with PGF2αand exposed to agents that target PGF2α signaling was assessed...
December 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27484400/helicobacter-pylori-infection-contributes-to-placental-impairment-in-preeclampsia-basic-and-clinical-evidences
#10
Nicoletta Di Simone, Chiara Tersigni, Simona Cardaropoli, Francesco Franceschi, Fiorella Di Nicuolo, Roberta Castellani, Francesca Bugli, Chiara de Waure, Anna Franca Cavaliere, Antonio Gasbarrini, Maurizio Sanguinetti, Giovanni Scambia, Tullia Todros
BACKGROUND: Preeclampsia (PE) is a major cause of maternal and neonatal morbidity and mortality. Epidemiological association between Helicobacter pylori (Hp) infection and PE onset has been widely shown. The aim of this study was to analyze a possible correlation between Hp infection and the severity of clinical presentation of PE and to identify an immunologic mechanism triggered by Hp infection potentially contributing to the pathogenesis of PE. MATERIALS AND METHODS: Sera from 93 preeclamptic women and 87 healthy pregnant women were tested for Hp infection by immunoassay and for anti-CagA antibodies by Western blot assay...
August 3, 2016: Helicobacter
https://www.readbyqxmd.com/read/27391266/whole-genome-pathway-analysis-identifies-an-association-of-cadmium-response-gene-loss-with-copy-number-variation-in-mutant-p53-bearing-uterine-endometrial-carcinomas
#11
Joe Ryan Delaney, Dwayne G Stupack
BACKGROUND: Massive chromosomal aberrations are a signature of advanced cancer, although the factors promoting the pervasive incidence of these copy number alterations (CNAs) are poorly understood. Gatekeeper mutations, such as p53, contribute to aneuploidy, yet p53 mutant tumors do not always display CNAs. Uterine Corpus Endometrial Carcinoma (UCEC) offers a unique system to begin to evaluate why some cancers acquire high CNAs while others evolve another route to oncogenesis, since about half of p53 mutant UCEC tumors have a relatively flat CNA landscape and half have 20-90% of their genome altered in copy number...
2016: PloS One
https://www.readbyqxmd.com/read/27374735/immunologic-evaluation-of-the-endometrium-with-a-levonorgestrel-intrauterine-device-in-solid-organ-transplant-women-and-healthy-controls
#12
Caron R Kim, Otoniel Martinez-Maza, Larry Magpantay, Clara Magyar, Jeffrey Gornbein, Radhika Rible, Peggy Sullivan
OBJECTIVE: The objective was to describe the endometrial milieu of stable transplant patients and healthy women before and after levonorgestrel intrauterine system (LNG-IUS) insertion. STUDY DESIGN: Women between 18 and 45 years of age desiring LNG-IUS insertion were enrolled with a 2:1 ratio of healthy to stable solid organ transplant patients. The first visit entailed a blood draw, uterine lavage and endometrial biopsy followed by LNG-IUS insertion. Follow-up visit involved a repeat serum draw, uterine lavage and endometrial biopsy...
November 2016: Contraception
https://www.readbyqxmd.com/read/27330834/leiomyosarcoma-of-the-broad-ligament-with-fever-presentation-a-case-report-and-review-of-literature
#13
Shahla Chaichian, Abolfazl Mehdizadehkashi, Kobra Tahermanesh, Bahram Moazzami, Fatemeh Jesmi, Moezedinjavad Rafiee, Katayoun Goharimoghaddam
INTRODUCTION: Leiomyosarcoma is a rare gynecologic malignancy that accounts for less than 1% of gynecological malignancies. Leiomyosarcoma of the broad ligament is an even rarer condition. According to Gardner's criteria, the diagnosis is made when the mass is completely separated from the uterus and adnexa. So far, 23 cases of primary leiomyosarcoma of the broad ligament have been reported in the literature published in English. CASE PRESENTATION: In September 2014, a 55-year-old, gravida 3, para 3 woman with a BMI of 30 and a chief complaint of fever and dizziness was admitted to the infectious-diseases ward of the Pars general hospital affiliated with Iran University of Medical Sciences in Tehran, Iran...
April 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/27323100/genetic-polymorphisms-in-patients-with-endometriosis-an-analytical-study-in-goi%C3%A3-nia-central-west-of-brazil
#14
K S F Silva, K K V O Moura
In healthy women, intra- and extracellular controls prevent the attachment and proliferation of ectopic endometrial cells. During endometriosis, abnormalities in these control mechanisms permit the survival of endometrial cells, their subsequent attachment to the peritoneal cavity, and disease progression. These abnormal cells cause invasion of tissues and induce an inflammatory response. Several genetic, immunological, and environmental factors contribute to this complex process. In this study we examined 6 polymorphisms for 6 different genes (p53; estrogen receptor β; progesterone receptor; GSTM1; GSTT1; CYP1A1)...
May 25, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27271316/composition-and-dynamics-of-the-uterine-nk-cell-kir-repertoire-in-menstrual-blood
#15
M A Ivarsson, N Stiglund, N Marquardt, M Westgren, S Gidlöf, N K Björkström
Uterine natural killer (NK) cells are abundantly present in endometrium and decidua. Their function is governed by interactions between killer cell immunoglobulin-like receptors (KIRs) and cognate human leukocyte antigen (HLA) class I ligands. These interactions have implications for reproductive success. Whereas most uterine NK cells are known to express KIRs, little information is available about KIR repertoire formation and stability over time. This is primarily due to inherent difficulties in gaining access to human uterine tissue...
June 8, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27235632/stat4-single-nucleotide-gene-polymorphisms-and-susceptibility-to-endometriosis-related-infertility
#16
Mohammad Reza Zamani, Arash Salmaninejad, Firouzeh Akbari Asbagh, Ahmad Masoud, Nima Rezaei
INTRODUCTION: Endometriosis is a multifactorial benign gynecologic disorder, characterized by the ectopic growth of misplaced endometrial cells with complex genetic inheritance and changing of some immune based factors and also shares some autoimmune characteristics. However, it is not clear yet that how and when these immunological factors affect the initiation or progression of the disease. It has been shown that STAT4 is a predisposing gene in the development of some autoimmune diseases...
August 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27149136/paraneoplastic-scleroderma-are-there-any-clues
#17
Hana Jedlickova, Veronika Durčanská, Vladimír Vašků
Dear Editor, Scleroderma associated with neoplasia is rare, with only a small number of cases reported. We describe 4 patients with paraneoplastic scleroderma who were treated at the I. Department of Dermatovenereology, St. Anna Hospital, during the period between 2004 and 2014. The patients were diagnosed with cholangiogenic carcinoma, endometrial carcinoma, prostatic adenocarcinoma, and adenoma of the suprarenal gland. In the case of concurrent scleroderma and tumor, four situations may occur: they can develop independently of each other; scleroderma may be induced by the tumor; the tumor can develop in the scleroderma; or the tumor can be induced by immunosuppressive therapy...
April 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/27125410/vitamin-c-is-effective-for-the-prevention-and-regression-of-endometriotic-implants-in-an-experimentally-induced-rat-model-of-endometriosis
#18
Ozlem Ulas Erten, Tuğba Altun Ensari, Berna Dilbaz, Huseyin Cakiroglu, Sadiman Kıykac Altinbas, Muzaffer Çaydere, Umit Goktolga
OBJECTIVE: Endometriosis is a chronic inflammatory disease pathologically defined as the presence of endometrial-like tissue outside the uterine cavity. It is one of the most important diseases affecting women of reproductive age. The process of endometriotic implant growth is mediated by many complex interactions of immunologic, hormonal, genetic, and environmental mediators. Vitamin C (ascorbic acid), besides playing a role in preventing invasion and metastasis, is an antioxidant having anti-inflammatory and -angiogenic effects...
April 2016: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27030529/histidine-rich-glycoprotein-derived-peptides-affect-endometrial-angiogenesis-in-vitro-but-has-no-effect-on-embryo-development
#19
Karin E Lindgren, Julius Hreinsson, Malin Helmestam, Kjell Wånggren, Inger Sundström Poromaa, Karin Kårehed, Helena Åkerud
UNLABELLED: Histidine-rich glycoprotein (HRG) is an abundant plasma protein involved in multiple biological processes including immunology, vascularisation, and coagulation. These processes are of importance in regulating embryo development and implantation. A specific polymorphism in the HRG gene, HRG C633T, has an impact on various aspects of fertility, such as oocyte quality, endometrial receptivity, and possibly the capacity of the embryo itself to implant. To further examine the potential role of the HRG C633T polymorphism in regulating endometrial angiogenesis and on embryo development, two HRG peptides were constructed...
June 2016: Systems Biology in Reproductive Medicine
https://www.readbyqxmd.com/read/26952748/our-current-understanding-of-the-pathophysiology-of-equine-endometritis-with-an-emphasis-on-breeding-induced-endometritis
#20
REVIEW
Mats H T Troedsson, Elizabeth M Woodward
Equine endometritis is characterized by the expression of pro- and anti- inflammatory cytokines and an influx of polymorphonuclear neutrophils (PMNs) into the uterus. Mares resistant to persistent endometritis clear the inflammation within 24-36 h after exposure to microorganisms or semen. These mares have a rapid increase of pro-inflammatory cytokines and an upregulation of inflammatory modulating cytokines within 6h after exposure to inflammatory challenge. In conjunction with effective uterine contractions, these events are believed to be responsible for the transient nature of the inflammation...
March 2016: Reproductive Biology
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