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Mohammad Ghafari, Wayne D Hutchison, Stewart J Campbell, Herbert Gleiter, Horst Hahn, Tao Feng
The residual electrical resistivity of metallic amorphous alloys, ρ0, is typically in the range 50 μΩ cm < ρ0 < 310 μΩ cm corresponding to a mean free path of conduction electrons of order a few interatomic distances. In crystalline metals with low defect levels such as Cu however, the residual electrical resistivity is about ρ0 ≈ 1.54 x 10-2 μΩ cm, leading to extensive progression of free electrons through the crystalline material, of typically up to 4 x 106 nm. The relatively "high" values for the electrical resistivity of distorted Sc75Fe25 alloys are discussed here within the framework of the wave character of electrons...
November 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Lauryn E Garner, Nathaniel Van Kirk, Eric D Tifft, Jason W Krompinger, Brittany M Mathes, Maria Fraire, Martha J Falkenstein, Brian P Brennan, Jesse M Crosby, Jason A Elias
OBJECTIVE: This study aimed to develop and validate the Distress Tolerance Scale-Short Form (DTS-SF), a modification of the original Distress Tolerance Scale, in a severe/complex sample of individuals with obsessive compulsive disorder (OCD). Currently, there are multiple self-report measurements of distress tolerance (DT), highlighting the need for a more refined measure. METHOD: Participants included 222 individuals with a primary diagnosis of OCD (57% male, average age = 31) seeking intensive/residential treatment...
November 15, 2017: Journal of Clinical Psychology
Pritam Roy, Amit Kumar Dinda, Susmitnarayan Chaudhury, Swagata Dasgupta
Formation of dityrosine (DT) cross-linkages in proteins is one of the most widely used markers of oxidative stress. Ribonuclease A (RNase A) has 6 Tyr residues and shows a characteristic DT fluorescence peak upon oxidation in addition to major changes in its secondary structure. DT formation can be prevented by using polyphenols (GA, ECG, and EGCG) which are known to have strong antioxidant activity. However, it has been observed that ECG and EGCG initiate protein oligomerization due to protein-polyphenol cross-linkages...
November 15, 2017: Biopolymers
Xingchen Li, Yang Xu, Yuan Zhu, Xiangyang Xu
BACKGROUND: Diffused-type giant cell tumor(Dt-GCT) is a rare, aggressive disorder of the joint synovium, bursa and tendon sheaths. Osseous erosions and subchondral cysts may develop as the result of synovium infiltration in Dt-GCT. We present a retrospective study of a series of patients who are diagnosed with Dt-GCT about the ankle joint, there clinical outcome is evaluated in this study. MATERIAL AND METHOD: Fifteen patients with radiologically and histologically confirmed Dt-GCT about the ankle joint were identified in our foot and ankle department...
November 14, 2017: BMC Musculoskeletal Disorders
Kareen N Tonsing, Martha Vungkhanching
The purpose of this study is to assess the feasibility of the distress thermometer (DT) and the accompanying problem checklist (PC) as a screening tool for psychological distress and the sources of those distress at an outpatient cancer treatment center in Central California. Forty-three patients completed the DT and the PC. Based on a recommended DT cutoff score of 4, patients were classified as "distressed" (>4) and "not-distressed" (<4). Respondents ranged in age from 34 to 87 years (mean = 60.44, SD = 12...
November 14, 2017: Social Work in Health Care
Tobias Killian, Steffen Dickopf, Alexander K Haas, Claudia Kirstenpfad, Klaus Mayer, Ulrich Brinkmann
We have devised an effective and robust method for the characterization of gene-editing events. The efficacy of editing-mediated mono- and bi-allelic gene inactivation and integration events is quantified based on colony counts. The combination of diphtheria toxin (DT) and puromycin (PM) selection enables analyses of 10,000-100,000 individual cells, assessing hundreds of clones with inactivated genes per experiment. Mono- and bi-allelic gene inactivation is differentiated by DT resistance, which occurs only upon bi-allelic inactivation...
November 13, 2017: Scientific Reports
Marina Lermenn Vidal, Guilherme Ferreira Rego, Gil Mendes Viana, Lucio Mendes Cabral, Juliana Primo Basílio Souza, Nick Silikas, Luis Felipe Schneider, Larissa Maria Cavalcante
OBJECTIVE: Investigate physical and chemical properties of model composites formulated with quaternary ammonium salt monomers (QAS) at different concentrations and alkyl chains lengths METHODS: QAS with 12 dimethylaminododecyl methacrylate (DMADDM) and 16 dimethylaminohexadecyl methacrylate (DMAHDM) chains lengths were synthesized and incorporated at 5 and 10% in model composites, resulting in four groups: G12.5 (DMADDM 5%), G12.10 (DMADDM 10%), G16.5 (DMAHDM 5%), G16.10 (DMAHDM 10%)...
November 10, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
Aya Awad, Mohamed Bader-El-Den, James McNicholas, Jim Briggs
BACKGROUND: Mortality prediction of hospitalized patients is an important problem. Over the past few decades, several severity scoring systems and machine learning mortality prediction models have been developed for predicting hospital mortality. By contrast, early mortality prediction for intensive care unit patients remains an open challenge. Most research has focused on severity of illness scoring systems or data mining (DM) models designed for risk estimation at least 24 or 48h after ICU admission...
December 2017: International Journal of Medical Informatics
S Krüger, M K Boettger, T Hilberg
INTRODUCTION: Patients with haemophilia (PwH) suffer from an enhanced pain sensitivity due to repetitive joint bleedings. A comprehensive, quantitative examination of the somatosensory system has not been performed in this population to date. MATERIAL AND METHODS: Thirty patients with moderate or severe haemophilia A or B and 30 healthy controls were examined by means of Quantitative Sensory Testing to assess the function of the somatosensory system. Detection (DT) and pain thresholds (PT) were determined, amounting to a total of 13 parameters...
November 13, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
Miha Milek, Markus Landthaler
RNA-binding proteins are dynamic posttranscriptional regulators of gene expression. Identification of mRNA-binding proteins in a given experimental setting is thus of great importance. We describe a procedure to enrich for direct poly(A)(+) RNA protein binders by 4-thiouridine-enhanced UV cross-linking and oligo(dT) purification. Subsequent nuclease-mediated release of RNA-binding proteins (RBPs) from mRNA allows for detection of eluted proteins by mass spectrometry. In addition, we provide a comparative approach to detect differences in RBP binding activity upon a biological stimulus...
2018: Methods in Molecular Biology
Mohammed J Ajrash, Jafar Zanganeh, Behdad Moghtaderi
Venting is often used in process industries to reduce the possibility of dangerous rises in pressure levels and the severity of explosions. To date, the effectiveness of side-on venting on methane flame deflagration in large scale operations has not been clearly addressed. This work explicitly investigates the influences of side-on venting on varied methane flame deflagration concentrations in a 30m long Detonation Tube (DT). RESULTS: corresponding to this study prove the existence of a significant correlation between the fire and explosion driving parameters such as pressure rise and flame propagation velocity with the vent location...
November 7, 2017: Journal of Hazardous Materials
C Rochais, S Henry, M Hausberger
Distractibility (i.e. individual distraction from his ongoing activity) is thoughts to affect daily life. The present study develops an easy way to assess inter-individual variations of distractibility of an animal model, the domestic horse. We developed the 'distractibility test' (DT), based on auditory stimuli, a major source of distraction in daily life. We hypothesized that the broadcast of unusual sounds would provide a reliable source of distraction and that the responses to these unusual sounds would yield a good estimation of a horse's level of distractibility...
November 10, 2017: Scientific Reports
Renáta Szemerszky, Zsuzsanna Szabolcs, Tamás Bogdány, Gábor Jánossy, György Thuróczy, Ferenc Köteles
Empirical evidence supporting the effectiveness of pulsed (electro)magnetic field (PEMF) therapy on chronic and acute pain is equivocal. In the current randomized, double-blind, placebo-controlled experiment, impact of a commercially available whole-body PEMF mat on acute ischemic muscle pain induced in the forearm was studied with the participation of 70 healthy volunteers. The device emitted a pulsed magnetic field with a repetition frequency of 2.05Hz and a maximum flux density of 25.3μT (rms). The highest dB/dt was 48mT/s...
November 7, 2017: Physiology & Behavior
Meng Wei, Jun Li, Hongman Wang
Using data from the Chinese Longitudinal Health Longevity Survey of 2005, 2008 and 2011, the authors compared the difference in the disability trajectory (DT) of survivor, decedent and dropped-out survey respondents and examined gender differences in DT using a group-based trajectory model, gender differences in the impact of DT on mortality risk (MR) among older adults, and mediating effects of resources and health status during late life through survival analysis. This analysis shows that the DTs of the survivors, decedents and dropped-out respondents differ remarkably...
November 2, 2017: Archives of Gerontology and Geriatrics
Kohei Okino, Daisuke Sakamaki, Shota Hira, Yuki Inoue, Shu Seki
Herein we demonstrate the characteristic switching of the dimerization behaviors of amine-substituted dicyanomethyl radicals, from - to -dimerization, simply by varying the electron-donating substituents. Dicyanomethyl radicals with 4,4'-ditolylamine (DT·) and with phenothiazine (PT·) are in equilibrium between the monomeric radical form and the corresponding dimer connected by a reversible C-C bond (-dimer) in solutions. On the other hand, a radical with julolidine skeleton (JD·) do not undergo -dimerization and is isolated as stable radical in spite of the absence of bulky protecting groups...
November 10, 2017: Angewandte Chemie
Heiko Gaßner, Franz Marxreiter, Simon Steib, Zacharias Kohl, Johannes C M Schlachetzki, Werner Adler, Bjoern M Eskofier, Klaus Pfeifer, Jürgen Winkler, Jochen Klucken
Introduction: Cognitive and gait deficits are common symptoms in Parkinson's disease (PD). Motor-cognitive dual tasks (DTs) are used to explore the interplay between gait and cognition. However, it is unclear if DT gait performance is indicative for cognitive impairment. Therefore, the aim of this study was to investigate if cognitive deficits are reflected by DT costs of spatiotemporal gait parameters. Methods: Cognitive function, single task (ST) and DT gait performance were investigated in 67 PD patients...
2017: Frontiers in Neurology
Brandon N VanderVeen, Justin P Hardee, Dennis K Fix, James A Carson
While cancer-induced skeletal muscle wasting has been widely investigated, the drivers of cancer-induced muscle functional decrements are only beginning to be understood. Decreased muscle function impacts cancer patient quality of life and health status, and several potential therapeutics have failed in clinical trials due to a lack of functional improvement. Furthermore, systemic inflammation and intrinsic inflammatory signaling's role in the cachectic disruption of muscle function requires further investigation...
November 9, 2017: Journal of Applied Physiology
Małgorzata Figiel, Miroslav Krepl, Sangwoo Park, Jarosław Poznański, Krzysztof Skowronek, Agnieszka Gołąb, Taekjip Ha, Jiři Šponer, Marcin Nowotny
HIV-1 reverse transcriptase (HIV-1 RT) possesses both DNA polymerase activity and RNase H activity that act in concert to convert single-stranded RNA of the viral genome to double-stranded DNA that is then integrated into the DNA of the infected cell. Reverse transcriptase-catalyzed reverse transcription critically relies on the proper generation of a polypurine tract (PPT) primer. However, the mechanism of PPT primer generation and the features of the PPT sequence that are critical for its recognition by HIV-1 RT remain unclear...
November 9, 2017: Journal of Biological Chemistry
Marcin Kunecki, Tomasz Oleksy, Jolanta Biernat, Paweł Kukla, Katarzyna Szwajkos, Piotr Podolec, Marek Deja, Krzysztof Gołba, Wojciech Płazak
BACKGROUND: Despite progress in the invasive treatment of ischemic heart disease, the ability to limit ischemia-reperfusion (I/R) injury remains largely unrealized. Ischemic pre-conditioning (IPC) and post-conditioning (POC) induce the protective mechanisms of resistance against I/R injury. Stimulation of opioid receptors mimic the protective effect of IPC or POC in an animal models. We tested the hypothesis, that IPC and POC provide cardioprotection in opioid-dependent mechanism in human myocardium...
2017: Folia Medica Cracoviensia
Anthony M Barcia, Liang Zhou, Jay B Cook, Kenneth K Lindell, Rey D Gumboc, Aaron D Dykstra, Robert J Lachky, Steven H Shaha, Kenneth F Taylor
Diagnosis of occult scaphoid fractures remains a challenge. Traditional management consisting of 2 weeks of immobilization and repeat radiographs results in unnecessary immobilization of many patients without fracture. Magnetic resonance imaging (MRI) is sensitive but expensive. Digital tomography (DT) is an imaging technique that provides fine-cut visualization with minimal radiation exposure and may be used when there is high clinical suspicion despite negative findings on initial radiographs. The authors compared the ability of DT vs MRI to detect acute occult scaphoid fractures...
November 1, 2017: Orthopedics
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