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https://www.readbyqxmd.com/read/27930363/upregulated-mir-16-expression-is-an-independent-indicator-of-relapse-and-poor-overall-survival-of-colorectal-adenocarcinoma-patients
#1
Marios A Diamantopoulos, Christos K Kontos, Dimitrios Kerimis, Iordanis N Papadopoulos, Andreas Scorilas
BACKGROUND: Colorectal adenocarcinoma is one of the most common malignant tumors of the gastrointestinal tract and the second leading cause of cancer-related deaths among adults in Western countries. miR-16 is heavily involved in cancer progression. In this study, we examined the potential diagnostic and prognostic utility of miR-16 expression in colorectal adenocarcinoma. METHODS: Total RNA was extracted from 182 colorectal adenocarcinoma specimens and 86 non-cancerous colorectal mucosae...
December 8, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27925647/left-ventricular-function-assessed-by-one-point-carotid-wave-intensity-in-newly-diagnosed-untreated-hypertensive-patients
#2
Olga Vriz, Serena Favretto, Joanna Jaroch, Rychard Wojciech, Eduardo Bossone, Caterina Driussi, Francesco Antonini-Canterin, Paolo Palatini, Krystyna Loboz-Grudzien
OBJECTIVES: To investigate whether newly diagnosed untreated hypertensive patients show higher left ventricular (LV) contractility, as assessed by traditional echocardiographic indices and carotid wave intensity (WI) parameters, including amplitude of the peak during early (W1 ) and late systole (W2 ). METHODS: A total of 145 untreated hypertensive patients were compared with 145 age- and sex-matched normotensive subjects. They underwent comprehensive echocardiography and WI analysis...
November 28, 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27922889/pump-speed-optimization-in-stable-patients-with-a-left-ventricular-assist-device
#3
Lotte E Couperus, Victoria Delgado, Mand J H Khidir, Marijke P M Vester, Meindert Palmen, Marta Fiocco, Eduard R Holman, Laurens F Tops, Robert J M Klautz, Harriëtte F Verwey, Martin J Schalij, Saskia L M A Beeres
Optimal left ventricular assist device (LVAD) functioning and preservation of right ventricular (RV) function are major survival determinants in destination therapy (DT)-LVAD recipients. Currently, the indication for routine pump speed optimization in stable patients and its effect on RV function at follow-up remain underexplored. Hemodynamically stable patients (N=17, age 61 [interquartile range {IQR} 51-66]years; 13 [77%] male) underwent a routine speed ramp test. Echocardiographic images were obtained at incremental speed settings to determine optimal pump speed...
December 2, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27920833/the-association-between-defibrillation-shock-energy-and-acute-cardiac-damage-in-patients-with-implantable-cardioverter-defibrillators
#4
Daisuke Ishigaki, Daisuke Kutsuzawa, Takanori Arimoto, Tadateru Iwayama, Naoaki Hashimoto, Yu Kumagai, Satoshi Nishiyama, Hiroki Takahashi, Tetsuro Shishido, Takuya Miyamoto, Joji Nitobe, Akio Fukui, Tetsu Watanabe, Isao Kubota
BACKGROUND: The aim of this study was to establish a minimally invasive defibrillation testing (DT) protocol for patients with implantable cardioverter defibrillators (ICDs). METHODS: Two different energy DTs were performed, immediately after (15 J-DT) and 7 days after (≤10 J-DT) device implantation, in 20 consecutive ICD implantation patients. Cardiac-troponin T (c-TNT) and heart-type fatty acid binding protein (H-FABP) levels were measured before implantation, 2 h after implantation, and 1 day after each DT...
December 2016: Journal of Arrhythmia
https://www.readbyqxmd.com/read/27918055/the-5-chlorouracil-7-deazaadenine-base-pair-as-an-alternative-to-the-dt-da-base-pair
#5
E Eremeeva, M Abramov, P Marlière, P Herdewijn
5-Chloro-2'-deoxyuridine as a possible component of a chemically modified genome has been discussed in terms of its influence on duplex stability and DNA polymerase incorporation properties. The search for its counterpart among different deoxyadenosine analogs (7-deaza-, 8-aza- and 8-aza-7-deaza-2'-deoxyadenosines) showed that the stable duplex formation as well as the synthesis of long constructs, more than 2 kb, were successful with the 5-chloro-2'-deoxyuridine and 7-deaza-2'-deoxyadenosine combination and with Taq DNA polymerase...
December 5, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27915210/functional-brain-imaging-of-walking-while-talking-an-fnirs-study
#6
Florian G Metzger, Ann-Christine Ehlis, Florian B Haeussinger, Patrick Schneeweiss, Justin Hudak, Andreas J Fallgatter, Sabrina Schneider
Since functional imaging of whole body movements is not feasible with functional magnetic resonance imaging (fMRI), the present study presents in vivo functional near-infrared spectroscopy (fNIRS) as a suitable technique to measure body movement effects on fronto-temporo-parietal cortical activation in single and dual task paradigms. Previous fNIRS applications in studies addressing whole body movements were typically limited to the assessment of prefrontal brain areas. The current study investigated brain activation in the frontal, temporal and parietal cortex of both hemispheres using functional near-infrared spectroscopy (fNIRS) with two large 4 x 4 probe-sets with 24 channels each during single and dual gait tasks...
November 30, 2016: Neuroscience
https://www.readbyqxmd.com/read/27913256/rapid-upregulation-of-the-hippocampal-connexins-36-and-45-mrna-levels-during-memory-consolidation
#7
Siamak Beheshti, Reyhaneh Zeinali, Abolghasem Esmaeili
Gap junction channels are implicated in learning and memory process. However, their role on each of the particular stages of memory formation has been studied less. In this study, the time profile of the expression levels of hippocampal connexins 36 and 45 (Cx36 and Cx45) mRNAs was measured during memory consolidation, in a passive avoidance paradigm. Totally 30 adult male rats were distributed into 5 groups of each 6. At different times profiles (30min, 3, 6 and 24h) following training, rats were decapitated and their hippocampi were immediately removed and frozen in liquid nitrogen...
November 29, 2016: Behavioural Brain Research
https://www.readbyqxmd.com/read/27910995/a-diffusion-tensor-magnetic-resonance-imaging-study-of-paediatric-patients-with-severe-non-traumatic-brain-injury
#8
Erika Molteni, Maria A Rocca, Sandra Strazzer, Elisabetta Pagani, Katia Colombo, Filippo Arrigoni, Giacomo Boffa, Massimiliano Copetti, Valentina Pastore, Massimo Filippi
AIM: In this observational study using 3T magnetic resonance imaging (MRI) and diffusion tensor, we investigated the differential effects of pathology, stage of disease, state of consciousness, and aetiology on the modifications of supra- and infra-tentorial white matter tracts and their correlations with clinical scales in paediatric patients with severe non-traumatic brain injury. METHOD: Diffusion tensor magnetic resonance imaging (DT-MRI) was obtained from seven children with unresponsive wakefulness syndrome (UWS; five males, two females; age at event 5y; standard deviation [SD] 2y 1mo), six children in a minimally conscious state (MCS; three males, three females; age at event 5y 10mo; SD 5y), and 10 healthy children as controls(two males, eight females; age at study 10y 10mo; SD 2y 10mo)...
December 2, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27910679/neutron-emission-spectroscopy-of-dt-plasmas-at-enhanced-energy-resolution-with-diamond-detectors
#9
L Giacomelli, M Nocente, M Rebai, D Rigamonti, A Milocco, M Tardocchi, Z J Chen, T F Du, T S Fan, Z M Hu, X Y Peng, A Hjalmarsson, G Gorini
This work presents measurements done at the Peking University Van de Graaff neutron source of the response of single crystal synthetic diamond (SD) detectors to quasi-monoenergetic neutrons of 14-20 MeV. The results show an energy resolution of 1% for incoming 20 MeV neutrons, which, together with 1% detection efficiency, opens up to new prospects for fast ion physics studies in high performance nuclear fusion devices such as SD neutron spectrometry of deuterium-tritium plasmas heated by neutral beam injection...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910612/jet-diagnostic-enhancements-in-preparation-for-dt-operations
#10
J Figueiredo, A Murari, C Perez Von Thun, D Marocco, M Tardocchi, F Belli, M García Muñoz, A Silva, S Soare, T Craciunescu, M Santala, P Blanchard, I Balboa, N Hawkes
In order to complete the exploitation of the JET ITER-like Wall and to take full benefit from deuterium-tritium experiments on JET, a set of diagnostic system refurbishments or upgrades is in progress. These diagnostic enhancements focus mainly on neutron, gamma, fast ions, instabilities, and operations support. These efforts intend to provide better spatial, temporal, and energy resolution while increasing measurement coverage. Also previously non-existing capabilities, such as Doppler reflectometry is now available for scientific exploitation...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910566/hotspot-electron-temperature-from-x-ray-continuum-measurements-on-the-nif
#11
L C Jarrott, L R Benedetti, H Chen, N Izumi, S F Khan, T Ma, S R Nagel, O L Landen, A Pak, P K Patel, M Schneider, H A Scott
We report on measurements of the electron temperature in the hotspot of inertially confined, layered, spherical implosions on the National Ignition Facility using a differential filtering diagnostic. Measurements of the DT and DD ion temperatures using neutron time-of-flight detectors are complicated by the contribution of hot spot motion to the peak width, which produce an apparent temperature higher than the thermal temperature. The electron temperature is not sensitive to this non-thermal velocity and is thus a valuable input to interpreting the stagnated hot spot conditions...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910563/a-neutron-activation-spectrometer-and-neutronic-experimental-platform-for-the-national-ignition-facility-invited
#12
C B Yeamans, N Gharibyan
At the National Ignition Facility, the diagnostic instrument manipulator-based neutron activation spectrometer is used as a diagnostic of implosion performance for inertial confinement fusion experiments. Additionally, it serves as a platform for independent neutronic experiments and may be connected to fast recording systems for neutron effect tests on active electronics. As an implosion diagnostic, the neutron activation spectrometers are used to quantify fluence of primary DT neutrons, downscattered neutrons, and neutrons above the primary DT neutron energy created by reactions of upscattered D and T in flight...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910525/application-of-the-coincidence-counting-technique-to-dd-neutron-spectrometry-data-at-the-nif-omega-and-z
#13
B Lahmann, L M Milanese, W Han, M Gatu Johnson, F H Séguin, J A Frenje, R D Petrasso, K D Hahn, B Jones
A compact neutron spectrometer, based on a CH foil for the production of recoil protons and CR-39 detection, is being developed for the measurements of the DD-neutron spectrum at the NIF, OMEGA, and Z facilities. As a CR-39 detector will be used in the spectrometer, the principal sources of background are neutron-induced tracks and intrinsic tracks (defects in the CR-39). To reject the background to the required level for measurements of the down-scattered and primary DD-neutron components in the spectrum, the Coincidence Counting Technique (CCT) must be applied to the data...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910508/a-particle-x-ray-temporal-diagnostic-pxtd-for-studies-of-kinetic-multi-ion-effects-and-ion-electron-equilibration-rates-in-inertial-confinement-fusion-plasmas-at-omega-invited
#14
H Sio, J A Frenje, J Katz, C Stoeckl, D Weiner, M Bedzyk, V Glebov, C Sorce, M Gatu Johnson, H G Rinderknecht, A B Zylstra, T C Sangster, S P Regan, T Kwan, A Le, A N Simakov, W T Taitano, L Chacòn, B Keenan, R Shah, G Sutcliffe, R D Petrasso
A Particle X-ray Temporal Diagnostic (PXTD) has been implemented on OMEGA for simultaneous time-resolved measurements of several nuclear products as well as the x-ray continuum produced in High Energy Density Plasmas and Inertial Confinement Fusion implosions. The PXTD removes systematic timing uncertainties typically introduced by using multiple instruments, and it has been used to measure DD, DT, D(3)He, and T(3)He reaction histories and the emission history of the x-ray core continuum with relative timing uncertainties within ±10-20 ps...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910487/combined-neutron-and-x-ray-imaging-at-the-national-ignition-facility-invited
#15
C R Danly, K Christensen, V E Fatherley, D N Fittinghoff, G P Grim, R Hibbard, N Izumi, D Jedlovec, F E Merrill, D W Schmidt, R A Simpson, K Skulina, P L Volegov, C H Wilde
X-ray and neutrons are commonly used to image inertial confinement fusion implosions, providing key diagnostic information on the fuel assembly of burning deuterium-tritium (DT) fuel. The x-ray and neutron data provided are complementary as the production of neutrons and x-rays occurs from different physical processes, but typically these two images are collected from different views with no opportunity for co-registration of the two images. Neutrons are produced where the DT fusion fuel is burning; X-rays are produced in regions corresponding to high temperatures...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910455/high-resolution-measurements-of-the-dt-neutron-spectrum-using-new-cd-foils-in-the-magnetic-recoil-neutron-spectrometer-mrs-on-the-national-ignition-facility
#16
M Gatu Johnson, J A Frenje, R M Bionta, D T Casey, M J Eckart, M P Farrell, G P Grim, E P Hartouni, R Hatarik, M Hoppe, J D Kilkenny, C K Li, R D Petrasso, H G Reynolds, D B Sayre, M E Schoff, F H Séguin, K Skulina, C B Yeamans
The Magnetic Recoil neutron Spectrometer (MRS) on the National Ignition Facility measures the DT neutron spectrum from cryogenically layered inertial confinement fusion implosions. Yield, areal density, apparent ion temperature, and directional fluid flow are inferred from the MRS data. This paper describes recent advances in MRS measurements of the primary peak using new, thinner, reduced-area deuterated plastic (CD) conversion foils. The new foils allow operation of MRS at yields 2 orders of magnitude higher than previously possible, at a resolution down to ∼200 keV FWHM...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910431/sensitivity-of-chemical-vapor-deposition-diamonds-to-dd-and-dt-neutrons-at-omega-and-the-national-ignition-facility
#17
N V Kabadi, H Sio, V Glebov, M Gatu Johnson, A MacPhee, J A Frenje, C K Li, F Seguin, R Petrasso, C Forrest, J Knauer, H G Rinderknecht
The particle-time-of-flight (pTOF) detector at the National Ignition Facility (NIF) is used routinely to measure nuclear bang-times in inertial confinement fusion implosions. The active detector medium in pTOF is a chemical vapor deposition diamond. Calibration of the detectors sensitivity to neutrons and protons would allow measurement of nuclear bang times and hot spot areal density (ρR) on a single diagnostic. This study utilizes data collected at both NIF and Omega in an attempt to determine pTOF's absolute sensitivity to neutrons...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910394/determination-of-relative-krypton-fission-product-yields-from-14-mev-neutron-induced-fission-of-238-u-at-the-national-ignition-facility
#18
E R Edwards, W S Cassata, C A Velsko, C B Yeamans, D A Shaughnessy
Precisely-known fission yield distributions are needed to determine a fissioning isotope and the incident neutron energy in nuclear security applications. 14 MeV neutrons from DT fusion at the National Ignition Facility induce fission in depleted uranium contained in the target assembly hohlraum. The fission yields of Kr isotopes (85m, 87, 88, and 89) are measured relative to the cumulative yield of (88)Kr and compared to previously tabulated values. The results from this experiment and England and Rider are in agreement, except for the (85m)Kr/(88)Kr ratio, which may be the result of incorrect nuclear data...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910309/spatial-resolution-measurements-of-the-advanced-radiographic-capability-x-ray-imaging-system-at-energies-relevant-to-compton-radiography
#19
G N Hall, N Izumi, O L Landen, R Tommasini, J P Holder, D Hargrove, D K Bradley, A Lumbard, J G Cruz, K Piston, J J Lee, E Romano, P M Bell, A C Carpenter, N E Palmer, B Felker, V Rekow, F V Allen
Compton radiography provides a means to measure the integrity, ρR and symmetry of the DT fuel in an inertial confinement fusion implosion near peak compression. Upcoming experiments at the National Ignition Facility will use the ARC (Advanced Radiography Capability) laser to drive backlighter sources for Compton radiography experiments and will use the newly commissioned AXIS (ARC X-ray Imaging System) instrument as the detector. AXIS uses a dual-MCP (micro-channel plate) to provide gating and high DQE at the 40-200 keV x-ray range required for Compton radiography, but introduces many effects that contribute to the spatial resolution...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910305/comparison-of-polystyrene-scintillator-fiber-array-and-monolithic-polystyrene-for-neutron-imaging-and-radiography
#20
R Simpson, T E Cutler, C R Danly, M A Espy, J H Goglio, J F Hunter, A C Madden, D R Mayo, F E Merrill, R O Nelson, A L Swift, C H Wilde, T G Zocco
The neutron imaging diagnostic at the National Ignition Facility has been operating since 2011 generating neutron images of deuterium-tritium (DT) implosions at peak compression. The current design features a scintillating fiber array, which allows for high imaging resolution to discern small-scale structure within the implosion. In recent years, it has become clear that additional neutron imaging systems need to be constructed in order to provide 3D reconstructions of the DT source and these additional views need to be on a shorter line of sight...
November 2016: Review of Scientific Instruments
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