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https://www.readbyqxmd.com/read/28929689/-comparatively-evaluating-effect-contribution-of-promoting-blood-circulation-of-herb-pairs-containing-angelicae-sinensis-radix-on-xin-sheng-hua-granule-by-withdrawal-analysis
#1
Han-Qing Pang, Jun Wang, Yu-Ping Tang, Liang Wu, Hui-Qin Xu, Yi Jin, Zhen-Hua Zhu, Sheng-Liang Huang, Da-Zheng Sun, Jin-Ao Duan
Xin-Sheng-Hua granule (XSHG) is a popular remedy commonly used in clinic for the treatment of lochiostasis after delivery. To comparatively investigate the roles of herb pairs containing Angelicae Sinensis Radix (Danggui) upon the formula by evaluating the blood coagulation and hemorheology function in acute blood stasis rats, acute blood stasis rat model was established by ice water bath and subcutaneous injection of adrenaline. And the blood stasis mice were administrated intragastrically with different samples of the formula minus herb pairs containing Danggui and the whole formula (XSHG, SHD, DY, DC, DT, DH, DJ and DZ)...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28927061/5fu-resistance-caused-by-reduced-fluoro-deoxyuridine-monophosphate-and-its-reversal-using-deoxyuridine
#2
Ryutaro Mori, Manabu Futamura, Toshiyuki Tanahashi, Yoshihiro Tanaka, Nobuhisha Matsuhashi, Kazuya Yamaguchi, Kazuhiro Yoshida
The mechanism of 5-fluorouracil (5FU) resistance was investigated, focusing on the level of thymidylate synthase (TS) ternary complex formed with fluoro-deoxyuridine monophosphate (FdUMP). MKN45 and 5FU-resistant MKN45/F2R cells were treated with 5FU and fluoro-deoxyuridine (FdU) in combination with deoxyuridine (dU) and thymidine (dT). Subsequently, the levels of ternary complex were determined by western blotting and the cell viability was calculated using an MTT assay. MKN45/F2R cells exhibited 5FU resistance (56...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28925687/film-confinement-induced-jump-percolation-wetting-transition-in-amphiphilic-block-copolymer-films
#3
Namrata Salunke, Asritha Nallapaneni, Guangcui Yuan, Christopher M Stafford, Hui Niu, Matthew D Shawkey, Robert A Weiss, Alamgir Karim
We report a first-order like sharp surface wettability transition with varying film thickness dependent morphology in cast films of an amphiphilic triblock copolymer. Films comprised of poly(2-(N-ethylperfluotooctanesulfonamido) ethyl methylacrylate), poly(FOSM), and poly(N,N'-dimethyl acrylamide), poly(DMA), with thickness (h) in the transition-range, 200 < h < 300 nm, exhibited an abrupt hydrophobic to hydrophilic dynamic water contact angle transition. After an induction time, ti ≈ 40 to 180 s, water contact angle varied as θc ≈ 116° to 40° with an ultra-fast contact angle decay time constant, dθc/dt ≈ -18 °/s...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28924340/hypotony-management-through-transconjunctival-scleral-flap-resuturing-analysis-of-surgical-outcomes-and-success-predictors
#4
Ana Luiza B Scoralick, Izabela Almeida, Michele Ushida, Diego T Dias, Syril Dorairaj, Tiago S Prata, Fábio N Kanadani
AIM: To investigate surgical outcomes and success predictors of transconjunctival scleral flap resuturing for the management of hypotony due to overfiltration following trabeculectomy with mitomycin C. MATERIALS AND METHODS: Noncomparative, retrospective, interventional case series in which all glaucoma patients from two glaucoma services undergoing transconjunctival scleral flap resuturing between May 2012 and July 2016 were enrolled. Included eyes had to have hypotony [intraocular pressure (IOP) < 6 mm Hg] and/or hypotony maculopathy caused by excessive filtration following trabeculectomy...
May 2017: Journal of Current Glaucoma Practice
https://www.readbyqxmd.com/read/28923927/mif-and-d-dt-are-potential-disease-severity-modifiers-in-male-ms-subjects
#5
Gil Benedek, Roberto Meza-Romero, Kelley Jordan, Ying Zhang, Ha Nguyen, Gail Kent, Jia Li, Edwin Siu, Jenny Frazer, Marta Piecychna, Xin Du, Antoine Sreih, Lin Leng, Jack Wiedrick, Stacy J Caillier, Halina Offner, Jorge R Oksenberg, Vijayshree Yadav, Dennis Bourdette, Richard Bucala, Arthur A Vandenbark
Little is known about mechanisms that drive the development of progressive multiple sclerosis (MS), although inflammatory factors, such as macrophage migration inhibitory factor (MIF), its homolog D-dopachrome tautomerase (D-DT), and their common receptor CD74 may contribute to disease worsening. Our findings demonstrate elevated MIF and D-DT levels in males with progressive disease compared with relapsing-remitting males (RRMS) and female MS subjects, with increased levels of CD74 in females vs. males with high MS disease severity...
September 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28923789/assessing-the-efficacy-and-safety-of-an-11%C3%AE-hydroxysteroid-dehydrogenase-type-1-inhibitor-azd4017-in-the-idiopathic-intracranial-hypertension-drug-trial-iih-dt-clinical-methods-and-design-for-a-phase-ii-randomized-controlled-trial
#6
Keira Annie Markey, Ryan Ottridge, James L Mitchell, Caroline Rick, Rebecca Woolley, Natalie Ives, Peter Nightingale, Alexandra J Sinclair
BACKGROUND: Idiopathic intracranial hypertension (IIH) is a condition with few effective management options. So far, there have been no randomized controlled trials evaluating new treatments in IIH. OBJECTIVES: The purpose of this paper is to outline the trial design for the Idiopathic Intracranial Hypertension Drug Trial (IIH:DT), assessing an innovative medical treatment in IIH and the rationale for the chosen trial methodology. METHODS: IIH:DT is a phase II double-blind randomized placebo-controlled trial recruiting 30 female participants with active IIH (intracranial pressure >25cm H2 O and papilledema)...
September 18, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28922050/how-to-interpret-high-levels-of-distress-when-using-the-distress-thermometer-in-the-long-term-follow-up-clinic-a-study-with-acute-lymphoblastic-leukemia-survivors
#7
A J Pépin, S Lippé, M Krajinovic, C Laverdière, B Michon, D Sinnett, S Sultan
OBJECTIVES: Recent guidelines recommend to assess emotional distress in pediatric oncology during treatment and in after care. One tool used to do this is the distress thermometer (DT), a simple tool which has almost exclusively been studied in its screening abilities. Given its increased used as a measure of distress per se, it is necessary to document its concurrent validity. The goal of this study was to identify clinical domains (eg, depression, anxiety) and individual symptoms associated with pediatric cancer survivors' rating on the DT...
September 18, 2017: Pediatric Hematology and Oncology
https://www.readbyqxmd.com/read/28919920/virulence-determinants-of-west-nile-virus-how-can-these-be-used-for-vaccine-design
#8
REVIEW
Jaclyn A Kaiser, Tian Wang, Alan Dt Barrett
West Nile virus (WNV), a neurotropic mosquito-borne flavivirus, has become endemic in the USA and parts of Europe since 1999. There is no licensed WNV vaccine for humans. Considering the robust immunity from immunization with live, attenuated vaccines, a live WNV vaccine is an ideal platform for disease control. Animal and mosquito studies have identified a number of candidate attenuating mutations, including the structural proteins premembrane/membrane and envelope, and the nonstructural proteins NS1, NS2A, NS3, NS4A, NS4B and NS5, and the 3' UTR...
May 2017: Future Virology
https://www.readbyqxmd.com/read/28919427/age-dependent-atrial-arrhythmic-phenotype-secondary-to-mitochondrial-dysfunction-in-pgc-1%C3%AE-deficient-murine-hearts
#9
Haseeb Valli, Shiraz Ahmad, Karan Chadda, Ali Al-Hadithi, Andrew A Grace, Kamalan Jeevaratnam, Christopher L-H Huang
INTRODUCTION: Ageing and several age-related chronic conditions including obesity, insulin resistance and hypertension are associated with mitochondrial dysfunction and represent independent risk factors for atrial fibrillation (AF). MATERIALS AND METHODS: Atrial arrhythmogenesis was investigated in Langendorff-perfused young (3-4 month) and aged (>12 month), wild type (WT) and peroxisome proliferator activated receptor-γ coactivator-1β deficient (Pgc-1β(-/-)) murine hearts modeling age-dependent chronic mitochondrial dysfunction during regular pacing and programmed electrical stimulation (PES)...
September 14, 2017: Mechanisms of Ageing and Development
https://www.readbyqxmd.com/read/28914745/is-digital-tomosynthesis-on-par-with-computed-tomography-for-the-detection-and-measurement-of-pulmonary-nodules
#10
Xiang Wen Lee, Henry M Marshall, Steven C Leong, Rachael L O'Rourke, Karin Steinke, Negar Mirjalili, Rayleen V Bowman, Ian A Yang, Kwun M Fong
Chest digital tomosynthesis (DT) has potential advantages compared to computed tomography (CT) such as radiation dose reduction. However, the role of DT in pulmonary nodule management remains investigative. We compared DT against CT for pulmonary nodule detection and size measurement. A clinical population comprising 54 nodules from 30 patients and a screening population comprising 42 nodules from 52 patients were included. Scans were independently read by two radiologists. Agreement in nodule measurements between readers and between modalities was assessed by Bland-Altman analysis using a 95% level of significance...
September 13, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28910959/-ischemia-reperfusion-injury-study-in-isolated-mouse-hearts-using-a-pressure-volume-curve
#11
J B Jiang, Z W Huamei, Gourdie Robert G, Zhiwei Zhang
Objective: To establish and assess the feasibility and sensitivity of left ventricular elasticity, compliance and stiffness for study of ischemia/reperfusion injury in an isolated mouse heart model utilizing the pressure-volume curve framework. Methods: An isolated, balloon-in-ventricle, isovolumically contracting, crystalloid-perfused Langendorff heart preparation was set up from 15 male C57/6BL mice aged 12-14 weeks. End-systolic pressure-volume relationship (ESPVR) and end-diastolic pressure-volume relationship (EDPVR) were obtained by measuring left ventricular (LV) systolic pressure (LVSP) and diastolic pressure under different balloon volumes...
September 12, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28910365/acute-effects-of-strength-exercises-and-effects-of-regular-strength-training-on-cell-free-dna-concentrations-in-blood-plasma
#12
Suzan Tug, Anna-Katharina Tross, Patrick Hegen, Elmo Wanja Immanuel Neuberger, Susanne Helmig, Wolfgang Schöllhorn, Perikles Simon
Creatine kinase (CK) is a marker for muscle cell damage with limited potential as marker for training load in strength training. Recent exercise studies identified cell free DNA (cfDNA) as a marker for aseptic inflammation and cell damage. Here we overserved in a pilot study the acute effects during strength exercise and chronic effects of regular strength training on cfDNA concentrations over a period of four weeks in three training groups applying conservation training (CT) at 60% of the 1 repetition maximum, high intensity-low repetition training (HT) at 90% of the 1 repetition maximum and differential training (DT) at 60% of the 1 repetition maximum...
2017: PloS One
https://www.readbyqxmd.com/read/28906384/the-safety-and-efficacy-of-oral-anticoagulants-with-dual-versus-single-antiplatelet-therapy-in-patients-after-percutaneous-coronary-intervention-a-meta-analysis
#13
Jie Chen, Li-Yu Wang, Chao Deng, Xing-Hua Jiang, Tu-Gang Chen
BACKGROUND: A growing number of patients require oral anticoagulant (OAC) after undergoing percutaneous coronary intervention (PCI) with stent implantation due to the development of atrial fibrillation, but the optimal antithrombotic regimen remains controversial in these patients. METHODS: We systematically searched PUBMED, EMBASE, and CENTRAL from inception until September 2016 for randomized controlled trials or cohort studies that evaluated the comparative effects of TT versus DT...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28906378/the-need-for-psycho-oncological-support-for-melanoma-patients-central-role-of-patients-self-evaluation
#14
Simone Mayer, Martin Teufel, Norbert Schaeffeler, Ulrike Keim, Claus Garbe, Thomas Kurt Eigentler, Stephan Zipfel, Andrea Forschner
Despite an increasing number of promising treatment options, only a limited number of studies concerning melanoma patients' psycho-oncological distress have been carried out. However, multiple screening tools are in use to assess the need for psycho-oncological support. This study aimed first to identify parameters in melanoma patients that are associated with a higher risk for being psycho-oncologically distressed and second to compare patients' self-evaluation concerning the need for psycho-oncological support with the results of established screening tools...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28906062/gemcitabine-pyrrologemcitabine-and-2-fluoro-2-deoxycytidines-synthesis-physical-properties-and-impact-of-sugar-fluorination-on-silver-ion-mediated-base-pairing
#15
Frank Seela, Xiurong Guo, Peter Leonard, Sachin Asaram Ingale
The stability of silver mediated "dC-dC" base pairs relies not only on the structure of the nucleobase but also is sensitive to structural modification on the sugar moiety. 2'-Fluorinated 2'-deoxycytidines with fluorine atoms in the arabino (up) and the ribo (down) configuration, as well as with geminal fluorine substitution (anticancer drug gemcitabine) and the novel fluorescent phenylpyrrolo-gemcitabine (phPyrGem) were synthesized. All nucleosides display the recognition face of naturally occurring 2'-deoxycytidine...
September 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28902391/parental-distress-6-months-after-a-pediatric-cancer-diagnosis-in-relation-to-family-psychosocial-risk-at-diagnosis
#16
Sasja A Schepers, Simone M Sint Nicolaas, Heleen Maurice-Stam, Lotte Haverman, Chris M Verhaak, Martha A Grootenhuis
BACKGROUND: This study was aimed at assessing fathers' and mothers' distress 6 months after a pediatric cancer diagnosis and at determining whether this is related to the level of family psychosocial risk 1 month after the diagnosis. METHODS: A sample of 192 families completed the electronic Psychosocial Assessment Tool (ePAT) 1 month after the diagnosis. At 6 months after the diagnosis, 119 mothers and 98 fathers completed the Distress Thermometer for Parents (DT-P; of which n=132 had also completed the ePAT at baseline)...
September 13, 2017: Cancer
https://www.readbyqxmd.com/read/28895187/education-related-inequality-in-restorative-dental-treatment-need-over-11-years-in-two-areas-of-finland
#17
Eero Raittio, Miira M Vehkalahti, Sari Helminen, Anna L Suominen
OBJECTIVES: This study aimed to analyse education-related inequality in restorative dental treatment need among adults aged 30 years and older living in Northern and Southern Finland in 2000 and 2011. METHODS: Data were taken from the Health 2000 and 2011 population-based follow-up surveys, including information gathered by interviews and clinical dental examination. Final effective sample sizes were 2423 people in 2000 and 1192 people in 2011. Restorative dental treatment need was measured with number of decayed and/or fractured teeth (DT + FrT)...
September 11, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/28894910/drought-alleviated-the-negative-effects-of-elevated-o3-on-lonicera-maackii-in-urban-area
#18
Sheng Xu, Wei Fu, Xingyuan He, Wei Chen, Weiwei Zhang, Bo Li, Yanqing Huang
Open top chambers were used to study the changes in photosynthesis, physiology and stomata characteristics in 1-year-old Lonicera maackii seedlings exposed to drought (DT, 30%-35% soil saturated water content) or/and elevated ozone (EO, 80 ppb). The results showed that DT or/and EO significantly decreased net photosynthetic rate (Pn), stomatal conductance (gs), maximum photochemical efficiency (Fv/Fm), but increased the activity of superoxide dismutase (SOD), and malondialdehyde content (p < 0.05). Compared with EO alone, the combination of EO and DT caused higher values in Pn, Fv/Fm, SOD activity (p < 0...
September 11, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28893187/does-dual-task-training-improve-walking-performance-of-older-adults-with-concern-of-falling
#19
B Wollesen, S Schulz, L Seydell, K Delbaere
BACKGROUND: Older adults with concerns of falling show decrements of gait stability under single (ST) and dual task (DT) conditions. To compare the effects of a DT training integrating task managing strategies for independent living older adults with and without concern about falling (CoF) to a non-training control group on walking performance under ST and DT conditions. METHODS: Single center parallel group single blind randomized controlled trial with group-based interventions (DT-managing balance training) compared to a control group (Ninety-five independent living older adults; 71...
September 11, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28891942/automatic-classification-of-tremor-severity-in-parkinson-s-disease-using-a-wearable-device
#20
Hyoseon Jeon, Woongwoo Lee, Hyeyoung Park, Hong Ji Lee, Sang Kyong Kim, Han Byul Kim, Beomseok Jeon, Kwang Suk Park
Although there is clinical demand for new technology that can accurately measure Parkinsonian tremors, automatic scoring of Parkinsonian tremors using machine-learning approaches has not yet been employed. This study aims to fill this gap by proposing machine-learning algorithms as a way to predict the Unified Parkinson's Disease Rating Scale (UPDRS), which are similar to how neurologists rate scores in actual clinical practice. In this study, the tremor signals of 85 patients with Parkinson's disease (PD) were measured using a wrist-watch-type wearable device consisting of an accelerometer and a gyroscope...
September 9, 2017: Sensors
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