keyword
MENU ▼
Read by QxMD icon Read
search

Frontotemporal deterioration

keyword
https://www.readbyqxmd.com/read/27929803/an-autopsy-verified-case-of-ftld-tdp-type-a-with-upper-motor-neuron-predominant-motor-neuron-disease-mimicking-mm2-thalamic-type-sporadic-creutzfeldt-jakob-disease
#1
Yuichi Hayashi, Yasushi Iwasaki, Akira Takekoshi, Nobuaki Yoshikura, Takahiko Asano, Maya Mimuro, Akio Kimura, Katsuya Satoh, Tetsuyuki Kitamoto, Mari Yoshida, Takashi Inuzuka
Here we report an autopsy-verified case of frontotemporal lobar degeneration (FTLD)-transactivation responsive region (TAR) DNA binding protein (TDP) type A with upper motor neuron-predominant motor neuron disease mimicking MM2-thalamic-type sporadic Creutzfeldt-Jakob disease (sCJD). A 69-year-old woman presented with an 11-month history of progressive dementia, irritability, insomnia, and gait disturbance without a family history of dementia or prion disease. Neurological examination revealed severe dementia, frontal signs, and exaggerated bilateral tendon reflexes...
November 2016: Prion
https://www.readbyqxmd.com/read/27831627/-pathological-gambling-and-epilepsy-in-patients-with-frontotemporal-dementia-two-case-reports
#2
Sheila Castro-Suarez, Peggy Martinez, María Meza
Frontotemporal dementia is a neurodegenerative disorder of which the behavioral variant is most common. This condition is currently considered the most common cause of dementia in people younger than 60 years. Here, we present two unrelated cases in which the typical symptoms were cognitive and behavioral progressive deterioration and psychiatric disorders such as disinhibition, impulsive acts, apathy, lack of empathy, stereotypies, and changes in eating habits. The first case exhibited pathological gambling as the initial symptom and resided in a psychiatric facility for a year...
July 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/27741293/transient-global-amnesia-deteriorates-the-network-efficiency-of-the-theta-band
#3
Young Ho Park, Jeong-Youn Kim, SangHak Yi, Jae-Sung Lim, Jae-Won Jang, Chang-Hwan Im, SangYun Kim
Acute perturbation of the hippocampus, one of the connector hubs in the brain, is a key step in the pathophysiological cascade of transient global amnesia (TGA). We tested the hypothesis that network efficiency, meaning the efficiency of information exchange over a network, is impaired during the acute stage of TGA. Graph theoretical analysis was applied to resting-state EEG data collected from 21 patients with TGA. The EEG data were obtained twice, once during the acute stage (< 24 hours after symptom onset) and once during the resolved stage (> 2 months after symptom onset) of TGA...
2016: PloS One
https://www.readbyqxmd.com/read/27380626/identifying-specific-clinical-symptoms-of-behavioral-variant-frontotemporal-dementia-versus-differential-psychiatric-disorders-in-patients-presenting-with-a-late-onset-frontal-lobe-syndrome
#4
Annemiek Dols, Saskia van Liempt, Flora Gossink, Welmoed A Krudop, Sietske Sikkes, Yolande A L Pijnenburg, Max L Stek
OBJECTIVE: Early differentiation between psychiatric disorders and behavioral variant frontotemporal dementia (bvFTD) is of paramount importance in patients with the late-onset frontal lobe syndrome. As bvFTD in patients will deteriorate, psychiatric disorders are treatable. To date, misdiagnosis often occurs due to an overlap of symptoms and lack of specific biomarkers. The aim of our study was to investigate whether specific symptoms could separate bvFTD from psychiatric disorders. METHODS: In a naturalistic, prospective, multicenter study, 137 patients (aged 45-75 years, 72% male) with a late-onset frontal lobe syndrome were included based on their scores on the Frontal Behavioral Inventory (FBI) and the Stereotypy Rating Inventory (SRI) from April 2011 to June 2013...
July 5, 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27367173/preservation-of-cognitive-and-musical-abilities-of-a-musician-following-surgery-for-chronic-drug-resistant-temporal-lobe-epilepsy-a-case-report
#5
Shantala Hegde, Rose Dawn Bharath, Malla Bhaskara Rao, Karthik Shiva, Arivazhagan Arimappamagan, Sanjib Sinha, Jamuna Rajeswaran, Parthasarathy Satishchandra
Mesial temporal lobe epilepsy (TLE) affects a range of cognitive functions and musical abilities. We report a 16-year-old boy diagnosed with drug-resistant right-medial TLE. He is a professional musician, trained in Carnatic classical music. Clinical, electrophysiological, magnetic resonance imaging (MRI) and positron emission tomography evaluation localized the seizure focus to the right medial temporal lobe. Patient underwent detailed neuropsychological evaluation and functional MRI (fMRI) for musical abilities prior to surgery...
July 1, 2016: Neurocase
https://www.readbyqxmd.com/read/27258418/uncovering-the-neural-bases-of-cognitive-and-affective-empathy-deficits-in%C3%A2-alzheimer-s-disease-and-the-behavioral-variant-of-frontotemporal-dementia
#6
Nadene Dermody, Stephanie Wong, Rebekah Ahmed, Olivier Piguet, John R Hodges, Muireann Irish
Loss of empathy is a core presenting feature of the behavioral-variant of frontotemporal dementia (bvFTD), resulting in socioemotional difficulties and behavioral transgressions. In contrast, interpersonal functioning remains relatively intact in Alzheimer's disease (AD), despite marked cognitive decline. The neural substrates mediating these patterns of loss and sparing in social functioning remain unclear, yet are relevant for our understanding of the social brain. We investigated cognitive versus affective aspects of empathy using the Interpersonal Reactivity Index (IRI) in 25 AD and 24 bvFTD patients and contrasted their performance with 22 age- and education-matched controls...
May 30, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27190928/behavioural-variant-frontotemporal-dementia-with-bilateral-insular-hypometabolism-a-case-report
#7
Ananya Mahapatra, Mamta Sood, Roshan Bhad, Manjari Tripathi
Fronto-Temporal Dementia (FTD) is a cluster of syndromes, characterized by progressive deterioration of cognition, language and/or behavioural changes associated with degeneration of the frontal and temporal lobes. A 53-year-old man was admitted with a history of gradually progressive behavioural disturbances, disinhibition, unprovoked anger outbursts, apathy, disorganised behaviour and impaired self-care. A clinical diagnosis of Fronto temporal Dementia (behavioural variant) was made. Extensive investigations found no abnormality except in FDG-PET scan of the brain which revealed hypo metabolism in bilateral anterior insular region...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27134676/use-of-interleukin-2-for-management-of-natalizumab-associated-progressive-multifocal-leukoencephalopathy-case-report-and-review-of-literature
#8
REVIEW
Divyanshu Dubey, Yinan Zhang, Donna Graves, Allen D DeSena, Elliot Frohman, Benjamin Greenberg
A 51-year-old woman with relapsing-remitting multiple sclerosis (RRMS) and 3-year history of natalizumab use developed expressive aphasia. A brain magnetic resonance image (MRI) showed left frontotemporal and right parietal lesion with mild contrast enhancement and cerebrospinal fluid (CSF) was positive for John Cunningham virus (JCV) by polymerase chain reaction (PCR). The patient received five cycles of plasmapheresis followed by intravenous immunoglobulin. Despite this intervention, her speech deteriorated and she developed right hemiparesis...
May 2016: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/27104894/dementia-and-rapid-mortality-who-is-at-risk
#9
Salka S Staekenborg, Yolande A L Pijnenburg, Afina W Lemstra, Philip Scheltens, Wiesje M Vd Flier
BACKGROUND: Dementia is typically known for its insidious onset and slowly progressive course, but a subgroup deteriorates fast and dies within years or even months. OBJECTIVE: The purpose of this study was to characterize dementia patients with a rapidly progressive course to death and evaluate their cause of death. METHODS: We retrospectively included all patients from the Amsterdam Dementia Cohort who died within two years after diagnosis...
April 19, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27042904/frontotemporal-dementias
#10
Elizabeth C Finger
PURPOSE OF REVIEW: This article reviews the common behavioral and cognitive features of frontotemporal dementia (FTD) and related disorders as well as the distinguishing clinical, genetic, and pathologic features of the most common subtypes. RECENT FINDINGS: Advances in clinical phenotyping, genetics, and biomarkers have enabled improved predictions of the specific underlying molecular pathology associated with different presentations of FTD. Evaluation of large international cohorts has led to recent refinements in diagnostic criteria for several of the FTD subtypes...
April 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27011635/study-of-visuospatial-skill-in-patients-with-dementia
#11
Asutosh Pal, Atanu Biswas, Alak Pandit, Arijit Roy, Debsankar Guin, Goutam Gangopadhyay, Asit Kumar Senapati
OBJECTIVES: To assess the visuospatial function in different types of dementia with the visual object and space perception (VOSP) battery and to relate the degree of visuospatial dysfunction with different types and stages of dementia. MATERIALS AND METHODS: A sample of 53 participants with dementia and equal number of age-, sex-, and education-matched controls were recruited for the study. Participants were evaluated for visuospatial skill using VOSP test battery...
January 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27011398/a-study-of-cortical-excitability-central-motor-conduction-and-cortical-inhibition-using-single-pulse-transcranial-magnetic-stimulation-in-patients-with-early-frontotemporal-and-alzheimer-s-dementia
#12
Sadanandavalli Retnaswami Chandra, Thomas Gregor Issac, B C Nagaraju, Mariamma Philip
INTRODUCTION: Degenerative cortical dementias affect several million people worldwide. Early diagnosis and categorization are essential for initiating appropriate pharmacological and nonpharmacological treatment so that deterioration can be postponed, and disability adjusted life years can be saved both for the patient and for the caregiver. Therefore, an early, simple, noninvasive biomarker will serve as a boon. PATIENTS AND METHODS: Patients who satisfied probable Alzheimer's disease (AD) or frontotemporal dementia (FTD) using international consensus criteria for FTD and National Institute of Neurological Disorders and Stroke-AD and Related Disorders Association criteria for AD were evaluated using single pulse transcranial magnetic stimulation with figure of eight coil and motor evoked potential from right first dorsal interossei...
January 2016: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/26890749/longitudinal-memory-profiles-in-behavioral-variant-frontotemporal-dementia-and-alzheimer-s-disease
#13
Samantha Schubert, Cristian E Leyton, John R Hodges, Olivier Piguet
BACKGROUND: Alzheimer's disease (AD) and behavioral-variant of frontotemporal dementia (bvFTD) can present with an overlapping neuropsychological profile, which often hinders their clinical differentiation. OBJECTIVE: To compare changes over time in memory, general cognition tasks, and functional scales between bvFTD and AD. METHODS: Consecutive cases diagnosed with probable bvFTD (n = 22) and typical AD (n = 31) with at least two clinical visits were selected...
2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26847526/advance-care-planning-in-motor-neuron-disease-a-qualitative-study-of-caregiver-perspectives
#14
Leigh Murray, Phyllis N Butow, Kate White, Matthew C Kiernan, Natalie D'Abrew, Helen Herz
BACKGROUND: Motor neuron disease is a fatal disease, characterised by progressive loss of motor function, often associated with cognitive deterioration and, in some, the development of frontotemporal dementia. Life-sustaining technologies are available (e.g. non-invasive ventilation and enteral nutrition) but may compromise quality of life for some patients. Timely commencement of 'Advance Care Planning' enables patients to participate in future care choices; however, this approach has rarely been explored in motor neuron disease...
May 2016: Palliative Medicine
https://www.readbyqxmd.com/read/26827640/different-patterns-of-cortical-gray-matter-loss-over-time-in-behavioral-variant-frontotemporal-dementia-and-alzheimer-s-disease
#15
Christiane Möller, Anne Hafkemeijer, Yolande A L Pijnenburg, Serge A R B Rombouts, Jeroen van der Grond, Elise Dopper, John van Swieten, Adriaan Versteeg, Martijn D Steenwijk, Frederik Barkhof, Philip Scheltens, Hugo Vrenken, Wiesje M van der Flier
We examined patterns of cortical thickness loss and cognitive decline over time in 19 patients with Alzheimer's disease (AD), 10 with behavioral variant frontotemporal dementia (bvFTD), and 34 controls with a mean interval of 2.1 ± 0.4 years. We measured vertexwise and regional cortical thickness changes of 6 lobar regions of interest between groups with the longitudinal FreeSurfer pipeline. Compared with controls, AD and bvFTD had a steeper rate of cognitive decline and showed faster cortical thinning per year...
February 2016: Neurobiology of Aging
https://www.readbyqxmd.com/read/26803583/validation-of-the-lille-s-apathy-rating-scale-in-very-mild-to-moderate-dementia
#16
Marta Fernández-Matarrubia, Jordi A Matías-Guiu, Teresa Moreno-Ramos, María Valles-Salgado, Alberto Marcos-Dolado, Rocío García-Ramos, Jorge Matías-Guiu
OBJECTIVE: Apathy is one of the most common and disabling syndromes of dementia and presents at all stages of the disease. Comprehensive and structured methods to assess apathy in dementia are still needed. Lille's Apathy Rating Scale (LARS) has shown good psychometric properties for apathy evaluation in Parkinson disease but has not been validated in dementia. The aim of this study was to validate the LARS in a cohort of patients with very mild to moderate dementia. METHODS: 101 patients with cognitive impairment (Clinical Dementia Rating ≤ 2) and 50 healthy subjects were recruited...
July 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/26682693/the-language-profile-of-behavioral-variant-frontotemporal-dementia
#17
Chris J D Hardy, Aisling H Buckley, Laura E Downey, Manja Lehmann, Vitor C Zimmerer, Rosemary A Varley, Sebastian J Crutch, Jonathan D Rohrer, Elizabeth K Warrington, Jason D Warren
BACKGROUND: The language profile of behavioral variant frontotemporal dementia (bvFTD) remains to be fully defined. OBJECTIVE: We aimed to quantify the extent of language deficits in this patient group. METHODS: We assessed a cohort of patients with bvFTD (n = 24) in relation to patients with semantic variant primary progressive aphasia (svPPA; n = 14), nonfluent variant primary progressive aphasia (nfvPPA; n = 18), and healthy age-matched individuals (n = 24) cross-sectionally and longitudinally using a comprehensive battery of language and general neuropsychological tests...
2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/26537902/frontotemporal-lobar-degeneration-mechanisms-and-therapeutic-strategies
#18
Ya-Qing Li, Meng-Shan Tan, Jin-Tai Yu, Lan Tan
Frontotemporal lobar degeneration (FTLD) is characterized by progressive deterioration of frontal and anterior temporal lobes of the brain and often exhibits frontotemporal dementia (FTD) on clinic, in <65-year-old patients at the time of diagnosis. Interdisciplinary approaches combining genetics, molecular and cell biology, and laboratory animal science have revealed some of its potential molecular mechanisms. Although there is still no effective treatment to delay, prevent, and reverse the progression of FTD, emergence of agents targeting molecular mechanisms has been beginning to promote potential pharmaceutical development...
November 4, 2015: Molecular Neurobiology
https://www.readbyqxmd.com/read/26459094/site-and-size-of-multiple-sclerosis-lesions-predict-enhanced-or-decreased-female-orgasmic-function
#19
Klemens Winder, Frank Seifert, Julia Koehn, Martina Deutsch, Tobias Engelhorn, Arnd Dörfler, De-Hyung Lee, Ralf A Linker, Max J Hilz
Neuroimaging identified brain areas involved in female orgasm. In women with multiple sclerosis (MS), associations between orgasmic function and the site and size of MS-related magnetic resonance imaging (MRI) changes are undetermined. This study intended to correlate MS-associated cerebral lesion load and location with clinical scores of female orgasmic function. In 50 women with MS (mean age 37.0 ± 9.9 years), we assessed Female Sexual Function Index (FSFI) scores for orgasmic frequency, difficulty and satisfaction...
December 2015: Journal of Neurology
https://www.readbyqxmd.com/read/26429216/motor-neuron-disease-current-management-and-future-prospects
#20
REVIEW
N G Simon, W Huynh, S Vucic, K Talbot, M C Kiernan
Motor neuron disease (MND) is characterised by progressive neurological deterioration and coexistence of upper and lower motor neuron signs. Over the past decade, evidence has emerged of unique pathophysiological processes, including glutamate-mediated excitotoxicity, which has resulted in the development of novel diagnostic investigations and uncovered potential therapeutic targets. Advances in genetics, including the recently discovered C9orf72 gene, have radically changed the pathological mindset, from MND being classified as a neuromuscular disease to one that MND forms a continuum with other primary neurodegenerative disorders, including frontotemporal dementia...
October 2015: Internal Medicine Journal
keyword
keyword
46163
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"