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Autism, autistic spectrum disorder, comorbidity, bipolar disorder,

Vincent Guinchat, Cora Cravero, Lautaro Diaz, Didier Périsse, Jean Xavier, Claire Amiet, Isabelle Gourfinkel-An, Nicolas Bodeau, Lee Wachtel, David Cohen, Angèle Consoli
During adolescence, some individuals with autism spectrum disorder (ASD) engage in severe challenging behaviors, such as aggression, self-injury, disruption, agitation and tantrums. We aimed to assess risk factors associated with very acute behavioral crises in adolescents with ASD admitted to a dedicated neurobehavioral unit. We included retrospectively in 2008 and 2009 29 adolescents and young adults with ASD hospitalized for severe challenging behaviors and proposed a guideline (Perisse et al., 2010) that we applied prospectively for 29 patients recruited for the same indications between 2010 and 2012...
March 2015: Research in Developmental Disabilities
Kiyoharu Takara, Tsuyoshi Kondo
BACKGROUND: The present study aims to examine if autism spectrum disorder (ASD) is a risk factor for suicide attempts among adult depressed patients and to elucidate the characteristics of suicide attempts in adult depressed patients with ASD. METHODS: We conducted a case-control study. Subjects consisted of 336 retrospectively recruited first-time visit patients to our outpatient clinic with a current major depressive episode; 31 of the 336 patients had attempted suicide...
2014: Annals of General Psychiatry
Makoto Ishitobi, Masao Kawatani, Mizuki Asano, Hirotaka Kosaka, Takashi Goto, Michio Hiratani, Yuji Wada
BACKGROUND: Bipolar disorder (BD) has been linked with the manifestation of catatonia in subjects with autism spectrum disorders (ASD). Idiopathic basal ganglia calcification (IBGC) is characterized by movement disorders and various neuropsychiatric disturbances including mood disorder. CASE: We present a patient with ASD and IBGC who developed catatonia presenting with prominent dystonic feature caused by comorbid BD, which was treated effectively with quetiapine...
October 2014: Brain & Development
Gagan Joshi, Joseph Biederman, Carter Petty, Rachel L Goldin, Stephannie L Furtak, Janet Wozniak
OBJECTIVE: Although mood dysregulation is frequently associated with autism spectrum disorders (ASD) and autistic traits are common in youth with bipolar disorder, uncertainties remain regarding the comorbid occurrence of bipolar disorder and ASD. This study examines the clinical and familial correlates of bipolar disorder when it occurs with and without ASD comorbidity in a well-characterized, research-referred population of youth with bipolar disorder. We hypothesized that in youth with bipolar disorder, the clinical and familial correlates of bipolar disorder will be comparable irrespective of the comorbidity with ASD...
June 2013: Journal of Clinical Psychiatry
Rebecca E Rosenberg, Walter E Kaufmann, J Kiely Law, Paul A Law
We used a national online registry to examine variation in cumulative prevalence of community diagnosis of psychiatric comorbidity in 4343 children with autism spectrum disorders (ASD). Adjusted multivariate logistic regression models compared influence of individual, family, and geographic factors on cumulative prevalence of parent-reported anxiety disorder, depression, bipolar disorder, and attention deficit/hyperactivity disorder or attention deficit disorder. Adjusted odds of community-assigned lifetime psychiatric comorbidity were significantly higher with each additional year of life, with increasing autism severity, and with Asperger syndrome and pervasive developmental disorder-not otherwise specified compared with autistic disorder...
2011: Autism Research and Treatment
Norbert Skokauskas, Louise Gallagher
BACKGROUND: This review aimed to find relevant published studies on the co-morbidity of autism and Asperger's syndrome with psychotic, anxiety and/or mood disorders, assess them, synthesize the findings, present an overview and make recommendations for future research. METHODS: Systematic literature searches were performed using several databases. Selected articles had to describe an original study that provided prevalence and/or incidence estimates on autism and/or Asperger's syndrome co-morbidity with psychotic, anxiety and/or mood disorders...
2010: Psychopathology
Rebecca E Rosenberg, J Kiely Law, Gayane Yenokyan, John McGready, Walter E Kaufmann, Paul A Law
OBJECTIVES: To examine patterns of autism spectrum disorder (ASD) inheritance and other features in twin pairs by zygosity, sex, and specific ASD diagnosis. DESIGN: Cross-sectional study. SETTING: Internet-based autism registry for US residents. PARTICIPANTS: Survey results from 277 twin pairs (210 dizygotic [DZ] and 67 monozygotic [MZ]) aged 18 years or younger with at least 1 affected twin. MAIN EXPOSURES: Zygosity and sex...
October 2009: Archives of Pediatrics & Adolescent Medicine
T Munesue, Y Ono, K Mutoh, K Shimoda, H Nakatani, M Kikuchi
BACKGROUND: Psychiatric comorbidity of autism spectrum disorder (ASD) has not been well examined. METHODS: Mood disorders in 44 consecutive outpatients with high-functioning ASD were examined at a university hospital according to DSM-IV. Inclusion criteria were an IQ of 70 or higher on the Wechsler Intelligence Scale and age of 12 years or over. RESULTS: Sixteen patients (36.4%) were diagnosed with mood disorder. Of these 16 patients, four were diagnosed as having major depressive disorder, two patients as bipolar I disorder, six patients as bipolar II disorder, and four patients as bipolar disorder not otherwise specified...
December 2008: Journal of Affective Disorders
Stephanie A Bryson, Susan K Corrigan, Thomas P McDonald, Cheryl Holmes
Despite the presence of significant psychiatric comorbidity among children with autism spectrum disorders (ASDs), little research exists on those who receive community-based mental health services. This project examined one year (2004) of data from the database maintained by 26 community mental health centers (CMHCs) in the Midwestern US state of Kansas. Children with autism were compared to children with other ASDs - Asperger's disorder, Rett's disorder, and PDD-NOS. Children with autism predictably received more special education services than children with other ASDs, while the latter were more likely to have experienced prior psychiatric hospitalization...
January 2008: Autism: the International Journal of Research and Practice
O Stahlberg, H Soderstrom, M Rastam, C Gillberg
Individuals with attention-deficit/hyperactivity disorder (AD/HD) and autism spectrum disorders (ASD) often display symptoms from other diagnostic categories. Exclusion criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) and the International Statistical Classification of Diseases and Related Health Problems (ICD-10) impede the use of categorical diagnoses to describe the particular problem constellation in a patient. In this study, we describe the prevalence and patterns of comorbid bipolar and psychotic disorders in 241 consecutively referred adult patients with AD/HD and/or ASD...
July 2004: Journal of Neural Transmission
R DeLong, C Nohria
The authors obtained neurological assessments and psychiatric family history data for 40 children with autistic spectrum disorders (autism, Asperger syndrome and pervasive developmental disorder). Neurological evaluation included EEG, MRI, karyotyping and positron emission tomography as indicated. Family history data were obtained from family members during long-term follow-up. 20 probands had positive neurological findings, 18 with negative family history. 14 had no neurological findings and positive family histories; they tended to have higher function...
May 1994: Developmental Medicine and Child Neurology
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