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https://www.readbyqxmd.com/read/29753689/molecular-characterization-and-gene-expression-analysis-of-hypoxia-inducible-factor-and-its-inhibitory-factors-in-kuruma-shrimp-marsupenaeus-japonicus
#1
Yo Okamura, Tohru Mekata, Gehad Elsaid Elshopakey, Toshiaki Itami
In shrimp aquaculture, overcrowded farming causes fluctuations in dissolved oxygen concentrations. Low-oxygen conditions (hypoxia) affect shrimp growth. Hypoxia-inducible factor (HIF) is a transcriptional factor in the basic helix-loop-helix/PAS family and is activated in response to hypoxic stress. However, little is known about HIF and other inhibitors of the HIF pathway in crustaceans. In this study, we cloned MjHIF-1α, an inhibitory factor, MjFIH-1 (factor inhibiting HIF-1α), and MjVHL (Von Hippel-Lindau tumor suppressor) from kuruma shrimp (Marsupenaeus japonicus)...
May 10, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29740509/chiari-i-malformation-with-acute-neurological-deficit-after-craniocervical-trauma-case-report-imaging-and-anatomic-considerations
#2
Josha A Woodward, David E Adler
Background: In patients with Chiari I malformation (CMI), the occurrence of acute neurologic deficit after craniocervical trauma is rare. However, the pathologic potential of exacerbating anatomic overcrowding of the posterior fossa has immense clinical consequences and prompt recognition is essential. Case Description: This case study describes a 41-year-old male who sustained a single blow to the face, fell, and struck the occiput. On admission, neurological examination revealed a profound paraparesis, upper extremity diplegia, a C4 sensory level and apnea that required intubation...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29739205/hollow-microgels-squeezed-in-overcrowded-environments
#3
A Scotti, M Brugnoni, A A Rudov, J E Houston, I I Potemkin, W Richtering
We study how a cavity changes the response of hollow microgels with respect to regular ones in overcrowded environments. The structural changes of hollow poly(N-isopropylacrylamide) microgels embedded within a matrix of regular ones are probed by small-angle neutron scattering with contrast variation. The form factors of the microgels at increasing compressions are directly measured. The decrease of the cavity size with increasing concentration shows that the hollow microgels have an alternative way with respect to regular cross-linked ones to respond to the squeezing due to their neighbors...
May 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29715251/time-spent-in-the-emergency-department-and-outcomes-in-patients-with-severe-sepsis-and-septic-shock
#4
RaeAnn Hirschy, Ethan Sterk, Rachel Dobersztyn, Megan A Rech
A majority of patients with severe sepsis and septic shock are first evaluated in the emergency department (ED). Methods such as screening tools have proven advantageous in earlier identification, allowing for timely initiation of treatment. Delay in symptom presentation and ED overcrowding contribute to deferment of sepsis bundle components and admission. To examine the impact of time from ED arrival to inpatient admission on mortality and length of stay (LOS) in patients with severe sepsis or septic shock...
April 2018: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/29706806/factors-associated-with-emergency-room-visits-within-30-days-of-outpatient-foot-and-ankle-surgeries
#5
Naohiro Shibuya, Himani Patel, Colin Graney, Daniel C Jupiter
The number of emergency department (ED) visits within 30 days after elective surgery has been utilized as a quality measure by many institutions. The significance of the measure as a postoperative complication in foot and ankle surgery, and risk factors for it, are unknown. We conducted a retrospective cohort study involving 386 patients to determine risk factors associated with ED visits after outpatient foot and ankle surgeries. After adjusting for clinically relevant covariates, we found that previous ED visits within 6 months of surgery, and nonelective surgeries were associated with the postoperative ED visit...
April 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29706056/changes-in-medical-care-due-to-the-absence-of-internal-medicine-physicians-in-emergency-departments
#6
Kyoung Ho Kim, Jang Young Lee, Won Suk Lee, Won Young Sung, Sang Won Seo
Objective: Especially in emergency departments (EDs), a lack of internal medicine (IM) residents in charge causes difficulties in medical care and ED overcrowding. Thus, protocols without IM residents in EDs is needed. This study aimed to investigate changes in medical care when emergency medicine residents replaced the roles of IM residents. Methods: This study was conducted at a single-site ED of a university medical center. The study group contained patients admitted to the IM department between September and December 2015, during which IM residents were absent in the ED...
April 30, 2018: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29702700/what-capacity-exists-to-provide-essential-inpatient-care-to-small-and-sick-newborns-in-a-high-mortality-urban-setting-a-cross-sectional-study-in-nairobi-city-county-kenya
#7
Georgina A V Murphy, David Gathara, Nancy Abuya, Jacintah Mwachiro, Sam Ochola, Robert Ayisi, Mike English
INTRODUCTION: Appropriate demand for, and supply of, high quality essential neonatal care is key to improving newborn survival but evaluating such provision has received limited attention in low- and middle-income countries. Moreover, specific local data are needed to support healthcare planning for this vulnerable population. METHODS: We conducted health facility assessments between July 2015-April 2016, with retrospective review of admission events between 1st July 2014 and 30th June 2015, and used estimates of population-based incidence of neonatal conditions in Nairobi to explore access and evaluate readiness of public, private not-for-profit (mission), and private-for-profit (private) sector facilities providing 24/7 inpatient neonatal care in Nairobi City County...
2018: PloS One
https://www.readbyqxmd.com/read/29702340/in-vitro-photodynamic-activity-of-lipid-vesicles-with-zinc-phthalocyanine-derivative-against-enterococcus-faecalis
#8
Lukasz Sobotta, Jolanta Dlugaszewska, Piotr Kasprzycki, Sebastian Lijewski, Anna Teubert, Jadwiga Mielcarek, Maria Gdaniec, Tomasz Goslinski, Piotr Fita, Ewa Tykarska
Zinc(II) phthalocyanine bearing eight non-peripheral 2-propoxy substituents was subjected to physicochemical study and, after incorporation in lipid vesicles, assessed as a potential photosensitizer for antibacterial photodynamic therapy. The phthalocyanine derivative obtained in the macrocyclization reaction was characterized by MS and NMR techniques. Moreover, its chemical purity was confirmed by HPLC analysis. X-ray structural analysis revealed that overcrowding of the phthalocyanine derivative leads to a strong out-of-plane distortion of the π-system of the macrocycle core...
April 17, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29701852/epidemiology-and-risk-factors-for-cryptosporidiosis-in-children-from-eight-low-income-sites-results-from-the-mal-ed-study
#9
Poonum S Korpe, Cristian Valencia, Rashidul Haque, Mustafa Mahfuz, Monica McGrath, Eric Houpt, Margaret Kosek, Benjamin J J McCormick, Pablo Penataro Yori, Sudhir Babji, Gagandeep Kang, Dennis Lang, Michael Gottlieb, Amidou Samie, Pascal Bessong, A S G Faruque, Esto Mduma, Rosemary Nshama, Alexandre Havt, Ila F N Lima, Aldo A M Lima, Ladaporn Bodhidatta, Ashish Shreshtha, William A Petri, Tahmeed Ahmed, Priya Duggal
Background: Cryptosporidium spp are enteric protozoa that cause significant morbidity and mortality in children worldwide. We characterized the epidemiology of Cryptosporidium in children from eight resource-limited sites of the MAL-ED study. Methods: Children were enrolled within 17 days of birth, and followed twice weekly for 24 months. Diarrheal and monthly surveillance stool samples were tested for Cryptosporidium by ELISA. Socioeconomic data were collected by survey and anthropometry was measured monthly...
April 26, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29665984/emergency-department-overcrowding-quality-improvement-in-a-taiwan-medical-center
#10
Chen-Mei Hsu, Li-Lin Liang, Yun-Te Chang, Wang-Chuan Juang
BACKGROUND/PURPOSE: Overcrowding of hospital emergency departments (ED) is a worldwide health problem. The Taiwan Joint Commission on Hospital Accreditation has stressed the importance of finding solutions to overcrowding, including, reducing the number of patients with >48 h stay in the ED. Moreover, the Ministry of Health and Welfare aims at transferring non-critical patients to district or regional hospitals. We report the results of our Quality Improvement Project (QIP) on ED overcrowding, especially focusing on reducing length of stay (LOS) in ED...
April 14, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29652816/the-emergency-medical-system-in-greece-opening-aeolus-bag-of-winds
#11
Ourania S Kotsiou, David S Srivastava, Panagiotis Kotsios, Aristomenis K Exadaktylos, Konstantinos I Gourgoulianis
An Emergency Medical Service (EMS) system must encompass a spectrum of care, with dedicated pre-hospital and in-hospital medical facilities. It has to be organised in such a way as to include all necessary services—such as triage accurate initial assessment, prompt resuscitation, efficient management of emergency cases, and transport to definitive care. The global economic downturn has had a direct effect on the health sector and poses additional threats to the healthcare system. Greece is one of the hardest-hit countries...
April 13, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29626129/light-activated-helical-inversion-in-cholesteric-liquid-crystal-microdroplets
#12
Piotr Sleczkowski, Ye Zhou, Supitchaya Iamsaard, Juan J de Pablo, Nathalie Katsonis, Emmanuelle Lacaze
Cholesteric liquid crystal (CLC) droplets exhibit nontrivial topological features, which are controlled by the ratio between the cholesteric pitch and the droplet radius. The radial spherical structure (RSS) is of particular interest, as it reveals an onion-like concentric organization of the cholesteric helices, leading to the expression of spherical Bragg microcavities. Using an overcrowded alkene-based unidirectional molecular motor as a dopant, we show that the topological defect structure in the droplet can be activated by illumination...
April 6, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29619913/emergency-department-boarding-a-descriptive-analysis-and-measurement-of-impact-on-outcomes
#13
Leila Salehi, Prashant Phalpher, Rahim Valani, Christopher Meaney, Qamar Amin, Kiki Ferrari, Mathew Mercuri
CLINICIAN'S CAPSULE What is known about the topic? Bed boarding is one of the major contributors to emergency department overcrowding. What did this study ask? What are the characteristics of patients with prolonged boarding times, and what are the impacts on patient-oriented outcomes? What did this study find? Patients who were older, sicker, and had isolation and telemetry requirements experienced longer boarding times, and longer inpatient length of stay even after correcting for confounders. Why does this study matter to clinicians? Organization-wide interventions to improve efficiency and flow are required to mitigate the burden of bed boarding...
April 5, 2018: CJEM
https://www.readbyqxmd.com/read/29619309/stimuli-directed-dynamic-reconfiguration-in-self-organized-helical-superstructures-enabled-by-chemical-kinetics-of-chiral-molecular-motors
#14
Jian Sun, Ruochen Lan, Yanzi Gao, Meng Wang, Wanshu Zhang, Ling Wang, Lanying Zhang, Zhou Yang, Huai Yang
Dynamic controllability of self-organized helical superstructures in spatial dimensions is a key step to promote bottom-up artificial nanoarchitectures and functional devices for diverse applications in a variety of areas. Here, a light-driven chiral overcrowded alkene molecular motor with rod-like substituent is designed and synthesized, and its thermal isomerization reaction exhibits an increasing structural entropy effect on chemical kinetic analysis in anisotropic achiral liquid crystal host than that in isotropic organic liquid...
February 2018: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/29608022/ivermectin-and-permethrin-for-treating-scabies
#15
REVIEW
Stefanie Rosumeck, Alexander Nast, Corinna Dressler
BACKGROUND: Scabies is an intensely itchy parasitic infection of the skin. It occurs worldwide, but is particularly problematic in areas of poor sanitation, overcrowding, and social disruption. In recent years, permethrin and ivermectin have become the most relevant treatment options for scabies. OBJECTIVES: To assess the efficacy and safety of topical permethrin and topical or systemic ivermectin for scabies in people of all ages. SEARCH METHODS: We searched the following databases up to 25 April 2017: the Cochrane Infectious Diseases Group Specialized Register, CENTRAL, MEDLINE, Embase, LILACS, and IndMED...
April 2, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29605480/emergency-department-boarding-and-adverse-hospitalization-outcomes-among-patients-admitted-to-a-general-medical-service
#16
Kito Lord, Vivek Parwani, Andrew Ulrich, Emily B Finn, Craig Rothenberg, Beth Emerson, Alana Rosenberg, Arjun K Venkatesh
OBJECTIVE: Overcrowding in the emergency department (ED) has been associated with patient harm, yet little is known about the association between ED boarding and adverse hospitalization outcomes. We sought to examine the association between ED boarding and three common adverse hospitalization outcomes: rapid response team activation (RRT), escalation in care, and mortality. METHOD: We conducted an observational analysis of consecutive patient encounters admitted from the ED to the general medical service between February 2013 and June 2015...
March 20, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29601462/incident-reporting-to-improve-patient-safety-the-effects-of-process-variance-on-pediatric-patient-safety-in-the-emergency-department
#17
Karen J OʼConnell, Kathy N Shaw, Richard M Ruddy, Prashant V Mahajan, Richard Lichenstein, Cody S Olsen, Tomohiko Funai, Stephen Blumberg, James M Chamberlain
OBJECTIVE: Medical errors threaten patient safety, especially in the pediatric emergency department (ED) where overcrowding, multiple handoffs, and workflow interruptions are common. Errors related to process variance involve situations that are not consistent with standard ED operations or routine patient care. SETTING/PARTICIPANTS: We performed a planned subanalysis of the Pediatric Emergency Care Applied Research Network incident reporting data classified as process variance events...
April 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29598769/revisiting-the-housing-health-relationship-for-hiv-positive-persons-qualitative-evidence-from-the-lower-manya-krobo-district-ghana
#18
Mabel Teye-Kau, Eric Y Tenkorang, Paul B Adjei
The relationship between housing and HIV infection is complex. On one hand, poor housing arrangements may affect the health of persons living with HIV/AIDS (PLWHAs). On the other hand, PLWHAs may be more likely to live in substandard homes because of their health. We used qualitative in-depth individual interviews of 38 PLWHAs attending voluntary counseling services at two government hospitals in the Lower Manya Krobo District (LMKD) in the Eastern region of Ghana to examine their housing and health outcomes...
March 1, 2018: Qualitative Health Research
https://www.readbyqxmd.com/read/29589695/-standing-orders-and-quality-of-care-at-triage-in-emergency-services-integrative-review
#19
Marie-Claude Lacroix, Roxane Borgès Da Silva
INTRODUCTION: Overcrowding of emergency services is a widespread problem in western countries. This situation results in negative patient outcomes and influences the quality of care. Standing orders are a possible way to improve the quality and performance of the health system. The aim of this article is to identify, based on a review of the literature, the effects of standing orders initiated by triage nurses in emergency services on the quality of care. METHODS: The quality of care dimensions of the Institute of Medicine (2001) were used as a frame of reference...
January 2018: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29584625/association-of-overcrowding-and-turnover-with-self-harm-in-a-swiss-pre-trial-prison
#20
Stéphanie Baggio, Laurent Gétaz, Nguyen Toan Tran, Nicolas Peigné, Komal Chacowry Pala, Diane Golay, Patrick Heller, Patrick Bodenmann, Hans Wolff
Self-harm is a common issue in detention and includes both suicidal and non-suicidal behaviours. Beyond well-known individual risk factors, institutional factors such as overcrowding (i.e., when the prison population exceeds its capacity) and turnover (i.e., the rate at which the prison population is renewed), may also increase the risk of self-harm. However, these factors are understudied or previous studies reported inconsistent findings. This study investigated the association of self-harm with overcrowding and turnover in the largest pre-trial Swiss prison in Geneva...
March 27, 2018: International Journal of Environmental Research and Public Health
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