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binari endometrial cancer

Josef Chovanec, Iveta Selingerova, Kristina Greplova, Sofie Leisby Antonsen, Monika Nalezinska, Claus Høgdall, Estrid Høgdall, Erik Søgaard-Andersen, Kirsten M Jochumsen, Pavel Fabian, Dalibor Valik, Lenka Zdrazilova-Dubska
Background: We investigated the efficacy of circulating biomarkers together with histological grade and age to predict deep myometrial invasion (dMI) in endometrial cancer patients. Methods: HE4ren was developed adjusting HE4 serum levels towards decreased glomerular filtration rate as quantified by the eGFR-EPI formula. Preoperative HE4, HE4ren, CA125, age, and grade were evaluated in the context of perioperative depth of myometrial invasion in endometrial cancer (EC) patients...
December 8, 2017: Oncotarget
Matthew Schlumbrecht, Jordan A Baeker Bispo, Raymond R Balise, Marilyn Huang, Brian Slomovitz, Erin Kobetz
BACKGROUND: Minorities have demonstrated an increased risk for type II endometrial cancers, but no data exists about risk among minority subpopulations. Our objective was to evaluate heterogeneity in risk of type II endometrial cancer (EC) histologies across race and Hispanic sub-groups using data from Florida's statewide cancer registry (FCDS). METHODS: FCDS contains data on N=26,416 women diagnosed with EC from 2004 to 2013. Our analysis included women ≥18years of age who were classified as non-Hispanic White (NHW), non-Hispanic Black (NHB) or belonged to one of five Hispanic sub-groups, and had a histology code consistent with type I or type II EC...
November 2017: Gynecologic Oncology
Amelie Schramm, Florian Ebner, Emanuel Bauer, Wolfgang Janni, Ulrike Friebe-Hoffmann, Miriam Pellegrino, Nikolaus De Gregorio, Thomas W P Friedl
PURPOSE: Histological confirmation of endometrial cancer by dilatation/curettage (D/C) in women with postmenopausal bleeding (PMB) can be challenging due to anesthesiological and/or surgical risks. Thus, less invasive methods for diagnostics are required to identify patients with minimal risk for endometrial cancer (EC) to avoid unnecessary surgical intervention. The objective of this single-center cohort study was to assess the diagnostic validity of transvaginal ultrasound (TVUS) measurements of endometrial thickness (ET) in patients with PMB for the detection of EC...
August 2017: Archives of Gynecology and Obstetrics
Koji Matsuo, Hiroko Machida, Omar M Ragab, Tsuyoshi Takiuchi, Huyen Q Pham, Lynda D Roman
OBJECTIVE: To examine trends of adjuvant radiotherapy choice and to examine associations between pelvic lymphadenectomy and radiotherapy choice for women with early-stage endometrial cancer. METHODS: The Surveillance, Epidemiology, and End Results Program was used to identify surgically treated stage I-II endometrial cancer between 1983 and 2012 (type 1 n=79,474, and type 2 n=25,020). Piecewise linear regression models were used to examine temporal trends of intracavitary brachytherapy (ICBT) and whole pelvic radiotherapy (WPRT) use, pelvic lymphadenectomy rate, and sampled node counts...
March 2017: Gynecologic Oncology
Fatemeh Kaveh, Lars O Baumbusch, Daniel Nebdal, Anne-Lise Børresen-Dale, Ole Christian Lingjærde, Hege Edvardsen, Vessela N Kristensen, Hiroko K Solvang
BACKGROUND: Detection and localization of genomic alterations and breakpoints are crucial in cancer research. The purpose of this study was to investigate, in a methodological and biological perspective, different female, hormone-dependent cancers to identify common and diverse DNA aberrations, genes, and pathways. METHODS: In this work, we analyzed tissue samples from patients with breast (n = 112), ovarian (n = 74), endometrial (n = 84), or cervical (n = 76) cancer...
November 22, 2016: BMC Cancer
Xi Yang, Qin-ping Liao, Cheng Wu, Nai-yi Zhang, Jian Zhao, Rui Chen, Nan Zhang, Xiu-hua Ma, Yu-nong Gao, Wan-li Gao, Hong Zheng, Zhen Zeng, Jia Wen, Ying Dong
OBJECTIVE: To evaluate the accuracy of endometrial cytology test (ECT) for the diagnosis of endometrial cancer or precancerous lesions and then discuss the value of ECT as a screening tool for endometrial cancer.Secondly, to investigate related characteristics and independent risk factors of epidemiology of endometrial carcinomas and atypical endometrial hyperplasia to advise proper crowd for endometrial carcinomas screening and monitoring. METHODS: Totally 1717 preoperative questionnaires on hysteroscopy + dilation & curettage, histopathology and endometrial cytological tests in Peking University First Hospital, People's Hospital of Beijing Daxing District and Beijing Cancer Hospital, from March 2009 to May 2013 were completed...
December 2013: Zhonghua Fu Chan Ke za Zhi
Joyce N Barlin, Robert A Soslow, Megan Lutz, Qin C Zhou, Caryn M St Clair, Mario M Leitao, Alexia Iasonos, Martee L Hensley, Richard R Barakat, Xavier Matias-Guiu, Nadeem R Abu-Rustum
OBJECTIVE: We propose a new staging system for stage I endometrial cancer and compare its performance to the 1988 and 2009 International Federation of Gynecology and Obstetrics (FIGO) systems. METHODS: We analyzed patients with 1988 FIGO stage I endometrial cancer from January 1993 to August 2011. Low-grade carcinoma consisted of endometrioid grade 1 to grade 2 lesions. High-grade carcinoma consisted of endometrioid grade 3 or nonendometrioid carcinomas (serous, clear cell, and carcinosarcoma)...
November 2013: International Journal of Gynecological Cancer
Kristy K Ward, Angelica M Roncancio, Nina R Shah, Mitzie-Ann Davis, Cheryl C Saenz, Michael T McHale, Steven C Plaxe
OBJECTIVE: We sought to quantify the relationship of uterine malignancy with body mass index (BMI). STUDY DESIGN: The University HealthSystem Consortium database was queried to identify all women undergoing total hysterectomy with a recorded BMI in the overweight and obese categories. Least squares regression was applied to evaluate the association between increasing BMI and the proportion of women with a diagnosis of uterine malignancy. Multivariate binary logistic regression was performed to adjust for other known risk factors including age, race, and other comorbidities...
December 2013: American Journal of Obstetrics and Gynecology
Joyce N Barlin, Qin Zhou, Caryn M St Clair, Alexia Iasonos, Robert A Soslow, Kaled M Alektiar, Martee L Hensley, Mario M Leitao, Richard R Barakat, Nadeem R Abu-Rustum
OBJECTIVE: The objectives of the study are to evaluate which clinicopathologic factors influenced overall survival (OS) in endometrial carcinoma and to determine if the surgical effort to assess para-aortic (PA) lymph nodes (LNs) at initial staging surgery impacts OS. METHODS: All patients diagnosed with endometrial cancer from 1/1993-12/2011 who had LNs excised were included. PALN assessment was defined by the identification of one or more PALNs on final pathology...
September 2013: Gynecologic Oncology
G Larry Maxwell, Jay Allard, Chandramouli V R Gadisetti, Tracy Litzi, Yovanni Casablanca, Uma Chandran, Kathleen M Darcy, Douglas A Levine, Andrew Berchuck, Chad A Hamilton, Thomas P Conrads, John I Risinger
OBJECTIVE: Previous studies suggest that differences in molecular features of endometrial cancers between racial groups may contribute to the poorer survival in Blacks. The objective of this investigation was to determine whether gene expression among endometrial cancers is different between Blacks and Whites. METHODS: Fresh frozen tumors from 25 Black patients were matched by stage, grade, and histology to endometrial cancer specimens from 25 White patients. Each case was macrodissected to produce specimens possessing a minimum of 75% cancer cellularity...
July 2013: Gynecologic Oncology
Budiman Kharma, Tsukasa Baba, Masaki Mandai, Noriomi Matsumura, Susan K Murphy, Hyun Sook Kang, Koji Yamanoi, Junzo Hamanishi, Ken Yamaguchi, Yumiko Yoshioka, Ikuo Konishi
Endometrial cancer, one of the most common gynecologic malignancies, is increasing in Japan, nearly doubling over the last decade. High-grade disease patients are often resistant to conventional chemotherapy with platinum agents; therefore, discovery of efficacious new drugs in this setting is required to benefit chemorefractory cases. The 50% growth-inhibitory (GI50) concentration of 27 clinically relevant drugs was measured in the NCI60 panel of cell lines. Gene expression data were analyzed using Bayesian binary regression, to first generate a response signature for each drug and then to calculate individual susceptibility scores using in vivo endometrial cancer data (GSE2109; http://www...
November 2013: International Journal of Cancer. Journal International du Cancer
Diego A Garcia-Dios, Diether Lambrechts, Lieve Coenegrachts, Ingrid Vandenput, An Capoen, Penelope M Webb, Kaltin Ferguson, Lars A Akslen, Bart Claes, Ignace Vergote, Philippe Moerman, Johan Van Robays, Janusz Marcickiewicz, Helga B Salvesen, Amanda B Spurdle, Frédéric Amant
OBJECTIVE: Endometrial cancer patients may benefit from systemic adjuvant chemotherapy, alone or in combination with targeted therapies. Prognostic and predictive markers are needed, however, to identify patients amenable for these therapies. METHODS: Primary endometrial tumors were genotyped for >100 hot spot mutations in genes potentially acting as prognostic or predictive markers. Mutations were correlated with tumor characteristics in a discovery cohort, replicated in independent cohorts and finally, confirmed in the overall population (n=1063)...
February 2013: Gynecologic Oncology
Nasuh Utku Dogan, Tayfun Gungor, Fatih Karsli, Emre Ozgu, Mustafa Besli
OBJECTIVE: To investigate the involvement of lymph nodes in para-aortic (PA) region particularly above and below the inferior mesenteric artery (IMA) in patients with endometrial cancer who had complete systemic pelvic and PA lymphadenectomy. METHODS: A total of 165 consecutive patients with endometrial cancer surgically staged from January 2008 to March 2011 in the gynecologic oncology unit of a tertiary maternity center, Zekai Tahir Burak Hospital, Ankara, Turkey, were included retrospectively...
May 2012: International Journal of Gynecological Cancer
Yonghua Chen, Yuanyang Yao, Lili Zhang, Xiaoping Li, Yue Wang, Lijun Zhao, Jianliu Wang, Gongwei Wang, Danhua Shen, Lihui Wei, Jianqing Zhao
PURPOSE: The main objective of this study was to refine more precisely the gene expression patterns used to distinguish serous from endometrioid endometrial carcinoma. METHODS: A low-density cDNA microarray containing 492 genes was designed and constructed. The gene expression profiles of 32 endometrioid and 5 serous endometrial cancer tissue samples were compared. The expression of 5 differentially expressed genes: NDC80, BUB1, FUT8, ANXA4 and BBC3 in endometrioid and serous adenocarcinoma samples was further evaluated by quantitative real-time PCR and immunohistochemistry...
August 2011: Experimental and Molecular Pathology
P Mhawech-Fauceglia, R F Herrmann, J Kesterson, I Izevbaye, S Lele, K Odunsi
AIMS: To explore and to compare the outcome of patients diagnosed with stage II/III/IV and stage III/IV endometrioid adenocarcinoma (EAC) with their serous carcinoma (USC) counterparts. MATERIALS AND METHODS: A total of 107 patients (73 EAC and 34 USC) were evaluated. For statistical analysis, the following baseline variables were considered for their prognostic value: the patient's age at presentation, the tumor size, the depth of myometrial invasion (MI), the lympho-vascular involvement (LVI) and the USC and the EAC subtypes (considered as binary variables)...
December 2010: European Journal of Surgical Oncology
Marcus Q Bernardini, Joan K Murphy
The development of surgical staging in the management of endometrial cancer has arisen over the last several decades with anticipated benefits including prognostic information, tailoring of adjuvant treatment, and a possible therapeutic effect. This review addresses the important issues surrounding lymphadenectomy in endometrial cancer. Other issues including the use of sentinel lymph node techniques, advanced imaging modalities and the consideration of a binary grading system to simplify triaging of patients will also be discussed...
March 15, 2009: Journal of Surgical Oncology
O Gemer, L Uriev, M Voldarsky, M Gdalevich, D Ben-Dor, F Barak, E Y Anteby, O Lavie
OBJECTIVE: To compare the interobserver reproducibility and prognostic value of the FIGO grading system with the histological parameters employed in the various recently proposed binary grading systems of endometrial cancer. METHODS: Seventy two consecutive stage I endometrioid endometrial carcinomas from hysterectomy specimens were independently graded by two pathologists. Clinical data and outcome were obtained from the patients' records. The following histological parameters were evaluated: FIGO grade (dichotomized to grades 1 and 2 vs...
March 2009: European Journal of Surgical Oncology
Lesley Lomo, Marisa R Nucci, Kenneth R Lee, Ming-Chieh Lin, Michelle S Hirsch, Christopher P Crum, George L Mutter
Diffuse p53 immunostaining distinguishes 85% of serous (Type II) from endometrioid (Type I) carcinomas and is an independent marker for poor prognosis. Interobserver reproducibility for the diagnosis of these entities, as well as selection and prediction of p53 immunostaining results, is unknown. Reproducibility of three pathologists regarding: (1) a two (I and II) and (2) three part classification (I, II or indeterminate); (3) recommendation for p53 staining and (4) expectations of p53 staining results were computed with the kappa (k) statistic...
August 2008: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Michael A Bidus, John I Risinger, Gadisetti V R Chandramouli, Lou A Dainty, Tracy J Litzi, Andrew Berchuck, J Carl Barrett, G Larry Maxwell
PURPOSE: To characterize the gene expression profiles of endometrioid endometrial cancers associated with lymph node metastasis in an effort to identify genes associated with metastatic spread. EXPERIMENTAL DESIGN: Tumors from 41 patients with endometrioid endometrial cancer grossly confined to the uterine cavity were evaluated. Positive lymph nodes were noted in 12 of 41 patients. RNA was analyzed for gene expression using the Affymetrix HG133A and HG133B GeneChip set, representing 45,000 array features covering >28,000 UniGene clusters...
January 1, 2006: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Francesca Sanseverino, Rosa Santopietro, Michela Torricelli, Giuseppina D'Andrilli, Giuseppe Russo, Gabriele Cevenini, Alessandro Bovicelli, Lorenzo Leoncini, Giovanni Scambia, Felice Petraglia, Pier Paolo Claudio, Antonio Giordano
PURPOSE: Endometrial cancer is the most common gynecologic malignancy. Established prognostic factors are histologic grade, depth of myometrial invasion, and extrauterine spread including retroperitoneal lymph node metastases. Tumorigenesis is a multistep process involving different genetic changes resulting in uncontrolled cellular proliferation, inhibition of apoptosis, and enhanced vascular proliferation among other events. Angiogenesis, the formation of new blood vessels from a preexisting vascular network, is necessary for invasive tumor growth and metastasis and constitutes an important point in the control of cancer progression...
January 2006: Cancer Biology & Therapy
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