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Lung SBRT

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https://www.readbyqxmd.com/read/28215851/a-novel-neoadjuvant-therapy-for-operable-locally-invasive-non-small-cell-lung-cancer-phase-i-study-of-neoadjuvant-stereotactic-body-radiotherapy-linnearre-i-nct02433574
#1
Nhu-Tram A Nguyen, Naghmeh Isfahanian, Gregory Pond, Wael Hanna, Jean-Claude Cutz, James Wright, Anand Swaminath, Yaron Shargall, Tom Chow, Marcin Wierzbicki, Gordon Okawara, Kimmen Quan, Christian Finley, Rosalyn Juergens, Theodoros Tsakiridis
BACKGROUND: Despite improved staging and surgical techniques, the rate of incomplete resection (R1) of non-small-cell lung cancer (NSCLC) has not significantly decreased. Patients with R1 resection have worse survival compared with those with complete resection (R0). Stereotactic body radiotherapy (SBRT) is a rapid and convenient radiotherapy treatment that delivers high-dose radiotherapy to tumors with high precision while sparing normal organs. Although its efficacy in treating small lung tumors is documented, its use as neoadjuvant therapy for locally advanced (LA) NSCLC has not been examined...
January 31, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28195507/predicting-risk-factors-for-radiation-pneumonitis-after-stereotactic-body-radiation-therapy-for-primary-or-metastatic-lung-tumors
#2
Mitsuru Okubo, Tomohiro Itonaga, Tatsuhiko Saito, Sachika Shiraishi, Ryuji Mikami, Hidetugu Nakayama, Akira Sakurada, Shinji Sugahara, Kiyoshi Koizumi, Koichi Tokuuye
OBJECTIVES: To investigate risk factors for radiation-induced pneumonitis (RP) after hypofractionated stereotactic body radiotherapy (SBRT) in patients with lung tumors. METHODS: From May 2004 to January 2016, 66 patients with 71 primary or metastatic lung tumors were treated with SBRT; these 71 cases were retrospectively analyzed for RP. To explore the risk factors for RP, the following factors were investigated: age, sex, performance status, operability, number of treatments, respiratory gating, pulmonary emphysema, tumor location, and subclinical interstitial lung disease (ILD)...
February 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28169042/nomogram-based-overall-survival-prediction-in-stereotactic-body-radiotherapy-for-oligo-metastatic-lung-disease
#3
S Tanadini-Lang, J Rieber, A R Filippi, M M Fode, J Streblow, S Adebahr, N Andratschke, O Blanck, J Boda-Heggemann, M Duma, M J Eble, I Ernst, M Flentje, S Gerum, P Hass, C Henkenberens, G Hildebrandt, D Imhoff, H Kahl, N D Klass, R Krempien, F Lohaus, C Petersen, E Schrade, T G Wendt, A Wittig, M Høyer, U Ricardi, F Sterzing, M Guckenberger
BACKGROUND: Radical local treatment of pulmonary metastases is practiced with increasing frequency due to acknowledgment and better understanding of oligo-metastatic disease. This study aimed to develop a nomogram predicting overall survival (OS) after stereotactic body radiotherapy (SBRT) for pulmonary metastases. PATIENTS AND METHODS: A multi-institutional database of 670 patients treated with SBRT for pulmonary metastases was used as training cohort. Cox regression analysis with bidirectional variable elimination was performed to identify factors to be included into the nomogram model to predict 2-year OS...
February 3, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28168606/strategies-for-translating-evidence-based-medicine-in-lung-cancer-into-community-practice
#4
REVIEW
Stephen A Rosenberg, Andrew M Baschnagel, Stephen J Bagley, Nadine Housri
The landscape of non-small cell lung cancer (NSCLC) treatment has rapidly evolved over the past decade. This is exemplified by the use of molecular targeted agents, immunotherapies, and newer technologies such as stereotactic body radiotherapy (SBRT). As the translation of preclinical discoveries into clinical practice continues, the effective dissemination and implementation of evidence-based treatment of NSCLC will remain a foremost challenge for oncologists. To further extend evidence-based medicine into the community setting, community oncologists are being engaged on multiple fronts including leadership and participation in national clinical trials and utilization of internet-based resources...
January 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28156666/patterns-of-radiation-therapy-technology-use-in-the-treatment-of-bone-metastases
#5
Robert Anton Olson, Shilo Lefresne, Michael R McKenzie
: 211 Background: In recent years, there has been a transition from two-dimensional radiation therapy (2DRT) planning towards more advanced techniques such as three-dimensional conformal radiation therapy (3D-CRT), volumetric modulated arc therapy (VMAT), and stereotactic body radiation therapy (SBRT). Our study aim was to analyze these trends in the treatment of bone metastases. METHODS: All patients aged 18 and older who had received palliative intent RT for bone metastases between 2009-2014 and referred to any 1 of 6 regional cancer centers in British Columbia, Canada were reviewed...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28143558/lung-metastases-treated-with-stereotactic-body-radiotherapy-the-rssearch%C3%A2-patient-registry-s-experience
#6
Anthony Ricco, Joanne Davis, William Rate, Jun Yang, David Perry, John Pablo, David D'Ambrosio, Sanjeev Sharma, Srinath Sundararaman, James Kolker, Kimberly M Creach, Rachelle Lanciano
OBJECTIVES: To report overall survival and local control for patients identified in the RSSearch® Patient Registry with metastatic cancer to the lung treated with SBRT. METHODS: Seven hundred two patients were identified with lung metastases in the RSSearch® Registry. Of these patients, 577 patients had SBRT dose and fractionation information available. Patients were excluded if they received prior surgery, radiation, or radiofrequency ablation to the SBRT treated area...
February 1, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28133758/feasibility-of-robotic-stereotactic-body-radiotherapy-of-lung-tumors-with-kilovoltage-x-ray-beams
#7
Susana V Sánchez-Arreola, Héctor M Garnica-Garza
PURPOSE: Robotic Stereotactic body radiation therapy (SBRT) for lung tumors is treatment modality that, for cases of inoperable lung tumors, has shown excellent treatment outcomes. The typical photon energy when delivering this type of treatments is 6MeV. In this work, using Monte Carlo simulation and realistic patient models we evaluate the characteristics of the absorbed dose distributions that result when x-ray beams of peak spectral energy of 220keV are used to irradiate lung tumors assuming a robotic SBRT delivery mode...
January 30, 2017: Medical Physics
https://www.readbyqxmd.com/read/28133340/-long-term-local-control-with-radiofrequency-ablation-or-radiotherapy-for-second-third-and-fourth-lung-tumors-after-lobectomy-for-primary-lung-cancer
#8
Hideoki Yokouchi, Masaki Miyazaki, Takeaki Miyamoto, Takafumi Minami, Fumio Tsuji, Koji Mikami, Kohei Murata
A 78-year-old woman developed second, third, and fourth lung tumors at intervals of 1-3 years after left upper lobectomy for primary lung cancer. The tumors were controlled with radiofrequency ablation(RFA)or conventionalconformalradiotherapy for 9 years postoperatively. For the treatment of second primary lung cancer or lung metastasis after surgical resection of the primary lung cancer, reoperation is not recommended because of the impaired respiratory reserve. Thus, local therapy such as radiotherapy or RFA is applied in some cases...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28130055/optimal-dose-and-fraction-number-in-sbrt-of-lung-tumours-a-radiobiological-analysis
#9
Ruggero Ruggieri, Pavel Stavrev, Stefania Naccarato, Nadejda Stavreva, Filippo Alongi, Alan E Nahum
The efficacy of Stereotactic Body Radiation Therapy (SBRT) in early-stage non-small cell lung cancer for severely hypofractionated schedules is clinically proven. Tumour control probability (TCP) modelling might further optimize prescription dose and number of treatment fractions (n). To this end, we will discuss the following controversial questions. Which is the most plausible cell-survival model at doses per fraction (d) as high as 20Gy? Do clinical data support a dose-response relationship with saturation over some threshold-dose? Given the reduced re-oxygenation for severe hypofractionation, is the inclusion of tumour hypoxia in TCP modelling relevant? Can iso-effective schedules be derived by assuming a homogeneous tumour-cell population with α/β≈10Gy, or should distinct cell subpopulations, with different α/β values, be taken into account? Is there scope for patient-specific individualization of n? Despite the difficulty of providing definite answers to the above questions, reasonable suggestions for lung SBRT can be derived from the literature...
January 24, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28117078/treating-patients-with-dynamic-wave-arc-first-clinical-experience
#10
Manuela Burghelea, Dirk Verellen, Jennifer Dhont, Cecilia Hung, Thierry Gevaert, Robbe Van den Begin, Christine Collen, Kenneth Poels, Koen Tournel, Marlies Boussaer, Cyril Jaudet, Truus Reynders, Viorica Simon, Mark de Ridder
BACKGROUND AND PURPOSE: Dynamic Wave Arc (DWA) is a system-specific noncoplanar arc technique that combines synchronized gantry-ring rotation with D-MLC optimization. This paper presents the clinical workflow, quality assurance program, and reports the geometric and dosimetric results of the first patient cohort treated with DWA. METHODS AND MATERIALS: The RayStation TPS was clinically integrated on the Vero SBRT platform for DWA treatments. The first 15 patients treated with DWA represent a broad range of treatment sites: breast boost, prostate, lung SBRT and bone metastases, which allowed us to explore the potentials and assess the limitations of the current DWA site-specific template solution...
January 20, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28114239/clinical-outcomes-of-stereotactic-body-radiotherapy-in-oligometastatic-gynecological-cancer
#11
Concetta Laliscia, Maria Grazia Fabrini, Durim Delishaj, Riccardo Morganti, Carlo Greco, Martina Cantarella, Roberta Tana, Fabiola Paiar, Angiolo Gadducci
OBJECTIVE: The objective of this study was to assess the role of stereotactic body radiotherapy (SBRT) in the treatment of distantly recurrent, oligometastatic gynecological cancer. METHODS: The hospital records of 45 patients with F-fluorodeoxyglucose (F-FDG) positron emission tomography positive, distantly recurrent, oligometastatic gynecological cancer were reviewed. All these patients had a number of target lesions less than 5, with largest diameter less than 6 cm...
February 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28110960/dose-effect-analysis-of-radiation-induced-rib-fractures-after-thoracic-sbrt
#12
Barbara Stam, Erik van der Bijl, Heike Peulen, Maddalena M G Rossi, José S A Belderbos, Jan-Jakob Sonke
BACKGROUND AND PURPOSE: To determine a dose-effect relation for radiation induced rib fractures after stereotactic body radiation therapy (SBRT) in early stage non-small cell lung cancer (NSCLC). Automatic rib delineation has enabled the analysis of a large patient group. MATERIAL AND METHODS: Four-hundred and sixty-six patients with stage I/II NSCLC received SBRT with a median of 54Gy in 3 fractions. The optimal EQD2-corrected dose parameter to predict (a)symptomatic fractures was found using Cox regression...
January 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28102933/what-if-a-tumor-is-significantly-enlarged-just-before-stereotactic-body-radiation-therapy-a-case-report-and-review-of-the-literature
#13
Hung-Jen Chen, Ji-An Liang, Chih-Yi Chen, Yang-Hao Yu, Chun-Ru Chien
Stereotactic body radiation therapy (SBRT) plays an important role in early stage non-small cell lung cancer. Tumor growth before radiotherapy planning (RTP) or during SBRT has been reported in lung cancer patients; however, little is known of growth during the period in-between (i.e. after RTP but before SBRT). An 83-year-old man referred to our hospital and diagnosed with medically inoperable non-small cell lung cancer was noted to have significant tumor progression on day 1 of cone beam computed tomography just before the planned SBRT delivery...
November 18, 2016: Thoracic Cancer
https://www.readbyqxmd.com/read/28089158/cardiac-dose-and-survival-after-stereotactic-body-radiotherapy-for-early-stage-non-small-cell-lung-cancer
#14
Amode R Tembhekar, Cari L Wright, Megan E Daly
INTRODUCTION: Recent analyses have identified cardiac dose as an important predictor of overall survival (OS) after chemoradiation for locally advanced non-small-cell lung cancer (NSCLC). However, the survival influence of the cardiac dose after stereotactic body radiotherapy (SBRT) is unknown. We performed a dose-volume histogram (DVH) analysis of patients treated with SBRT for early stage NSCLC to examine survival and cardiac toxicity. MATERIALS AND METHODS: We reviewed the medical records of patients who had undergone SBRT for early-stage NSCLC from June 2007 to June 2015 and documented the cardiac DVH parameters, including the maximum and mean dose and percentage of volume receiving >5, >10, >20, and >30 Gy (V5, V10, V20, and V30, respectively)...
December 22, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28073946/a-randomized-phase-iii-trial-of-comparing-two-dose-fractionations-stereotactic-body-radiotherapy-sbrt-for-medically-inoperable-stage-ia-non-small-cell-lung-cancer-or-small-lung-lesions-clinically-diagnosed-as-primary-lung-cancer-japan-clinical-oncology-group
#15
EDITORIAL
Tomoki Kimura, Yasushi Nagata, Junko Eba, Shuichi Ozawa, Satoshi Ishikura, Taro Shibata, Yoshinori Ito, Masahiro Hiraoka, Yasumasa Nishimura
A randomized Phase III trial commenced in Japan in February 2016. Currently, 42 Gy in four fractions of stereotactic body radiotherapy prescribed at the D95% of the planning target volume, which is considered equal to the commonly used 48 Gy in four fractions at the isocenter using an old dose calculation algorithm, is the standard treatment in Japan for medically inoperable Stage IA non-small cell lung cancer and small lung lesions clinically diagnosed as primary lung cancer. This study aims to examine the superiority of 55 Gy in four fractions over 42 Gy in four fractions...
January 9, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28070470/assessing-the-need-for-adjuvant-chemotherapy-after-stereotactic-body-radiation-therapy-in-early-stage-non-small-cell-lung-carcinoma
#16
Raphaël Jumeau, Houda Bahig, Édith Filion, Marie-Pierre Campeau, Louise Lambert, David Roberge, Andrei-Bogdan Gorgos, Toni Vu
PURPOSE: Surgery remains the standard treatment for medically operable patients with early-stage non-small cell lung carcinoma (NSCLC). Following surgical resection, adjuvant chemotherapy is recommended for large tumors >4 cm. For unfit patients, stereotactic body radiation therapy (SBRT) has emerged as an excellent alternative to surgery. This study aims to assess patterns of recurrence and discuss the role of chemotherapy after SBRT for NSCLC. METHODS: We reviewed patients treated with SBRT for primary early-stage NSCLC between 2009 and 2015...
November 29, 2016: Curēus
https://www.readbyqxmd.com/read/28057036/clinical-outcomes-of-stage-i-and-iia-non-small-cell-lung-cancer-patients-treated-with-stereotactic-body-radiotherapy-using-a-real-time-tumor-tracking-radiotherapy-system
#17
Norio Katoh, Itaru Soda, Hiroyasu Tamamura, Shotaro Takahashi, Yusuke Uchinami, Hiromichi Ishiyama, Kiyotaka Ota, Tetsuya Inoue, Rikiya Onimaru, Keiko Shibuya, Kazushige Hayakawa, Hiroki Shirato
PURPOSE: To investigate the clinical outcomes of stage I and IIA non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using a real-time tumor-tracking radiotherapy (RTRT) system. MATERIALS AND METHODS: Patterns-of-care in SBRT using RTRT for histologically proven, peripherally located, stage I and IIA NSCLC was retrospectively investigated in four institutions by an identical clinical report format. Patterns-of-outcomes was also investigated in the same manner...
January 5, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28054139/-local-ablative-radiotherapy-of-oligometastatic-colorectal-cancer
#18
C Petersen, T Gauer
BACKGROUND: Colorectal cancer (CRC) often presents as oligometastatic disease. Currently available intensive systemic treatment regimens, including combination chemotherapy and molecular targeted agents, result in tumor response and transient to long-term disease control in a high percentage of patients, thus raising the question of further management. Secondary resection and ablation, e.g. by surgery or radiofrequency may contribute to long-term survival and even be curative or at least allow a relevant chemotherapy-free interval...
February 2017: Der Radiologe
https://www.readbyqxmd.com/read/28054137/-local-treatment-of-solitary-intrapulmonary-malignant-nodules
#19
J Op den Winkel, F Eichhorn, S Rieken, H Dienemann
DEFINITION: Intrapulmonary nodules generally represent an incidental finding in the roentgenogram or computed tomography (CT) scan of the chest. They are defined as single, well-circumscribed, radiographic opaque lesions that measures up to 3 cm in diameter and are surrounded completely by aerated lung. The probability of malignancy directly correlates with increasing diameter. Lesions that have a diameter of 1 cm or larger require direct evaluation. THERAPY: Surgery is the first option for patients with a malignant lesion, given an acceptable perioperative risk; for high-risk patients either radiofrequency ablation (RFA) or stereotactic body radiation therapy (SBRT) should be offered...
February 2017: Der Radiologe
https://www.readbyqxmd.com/read/28048907/su-f-r-46-predicting-distant-failure-in-lung-sbrt-using-multi-objective-radiomics-model
#20
Z Zhou, M Folkert, P Iyengar, Y Zhang, J Wang
PURPOSE: To predict distant failure in lung stereotactic body radiation therapy (SBRT) in early stage non-small cell lung cancer (NSCLC) by using a new multi-objective radiomics model. METHODS: Currently, most available radiomics models use the overall accuracy as the objective function. However, due to data imbalance, a single object may not reflect the performance of a predictive model. Therefore, we developed a multi-objective radiomics model which considers both sensitivity and specificity as the objective functions simultaneously...
June 2016: Medical Physics
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