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Lung SBRT

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https://www.readbyqxmd.com/read/28325266/stage-i-small-cell-lung-cancer-a-new-potential-option-for-stereotactic-ablative-radiation-therapy-a-review-of-literature
#1
REVIEW
Filippo Alongi, Stefano Arcangeli, Berardino De Bari, Niccolò Giaj-Levra, Alba Fiorentino, Rosario Mazzola, Marco Trovò
Small cell lung cancer (SCLC) is relative rare histology in lung cancer patients. The standard treatment, in patients with an intra-thoracic disease, is represented by the use of concurrent chemo-radiotherapy; while patients with early SCLC stage, surgical resection could be recommended. Stereotactic body radiotherapy (SBRT) is a recently introduced technique allowing the delivery of very high radiation doses to limited target volumes and it is considered the standard approach in the treatment of not operable stage I Non Small-Cell Lung Cancer (NSCLC)...
April 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28323733/linear-endobronchial-ultrasound-guided-insertion-of-a-fiducial-marker-a-new-tool-for-tracking-central-lesions
#2
Alessio Casutt, Angela Koutsokera, Nicolas Peguret, Alban Lovis
Stereotactic body radiotherapy (SBRT) is an effective method for the treatment of localized primary lung tumors. Cyberknife, a highly accurate SBRT technique, follows the target during respiratory cycles using a metallic fiducial marker (FM) previously inserted into the lesion. Various methods have been described for the placement of an FM in peripheral pulmonary lesions; however, none of these is appropriate for mediastinal or hilar tumors. The placement of FMs in central lesions to achieve accurate SBRT is particularly relevant due to their higher mobility during respiratory and cardiac cycles...
April 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28317123/motion-management-strategies-and-technical-issues-associated-with-stereotactic-body-radiotherapy-of-thoracic-and-upper-abdominal-tumors-a-review-from-nrg-oncology
#3
Edward D Brandner, Indrin J Chetty, Tawfik G Giaddui, Ying Xiao, M Saiful Huq
The efficacy of stereotactic body radiotherapy (SBRT) has been well demonstrated. However, it presents unique challenges for accurate planning and delivery especially in the lungs and upper abdomen where respiratory motion can be significantly confounding accurate targeting and avoidance of normal tissues. In this paper we review the current literature on SBRT for lung and upper abdominal tumors with particular emphasis on addressing respiratory motion and its affects. We provide recommendations on strategies to manage motion for different, patient specific situations...
March 20, 2017: Medical Physics
https://www.readbyqxmd.com/read/28297459/on-the-use-of-a-convolution-superposition-algorithm-for-plan-checking-in-lung-stereotactic-body-radiation-therapy
#4
Nicholas Hardcastle, Bradley M Oborn, Annette Haworth
Stereotactic body radiation therapy (SBRT) aims to deliver a highly conformal ablative dose to a small target. Dosimetric verification of SBRT for lung tumors presents a challenge due to heterogeneities, moving targets, and small fields. Recent software (M3D) designed for dosimetric verification of lung SBRT treatment plans using an advanced convolution-superposition algorithm was evaluated. Ten lung SBRT patients covering a range of tumor volumes were selected. 3D CRT plans were created using the XiO treatment planning system (TPS) with the superposition algorithm...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297432/difference-in-dose-volumetric-data-between-the-analytical-anisotropic-algorithm-the-dose-to-medium-and-the-dose-to-water-reporting-modes-of-the-acuros-xb-for-lung-stereotactic-body-radiation-therapy
#5
Wambaka A Mampuya, Mitsuhiro Nakamura, Yoshinori Hirose, Takashi Ishigaki, Takashi Mizowaki, Masahiro Hiraoka
The purpose of this study was to evaluate the difference in dose-volumetric data between the analytical anisotropic algorithms (AAA) and the two dose reporting modes of the Acuros XB, namely, the dose to water (AXB-Dw) and dose to medium (AXB-Dm) in lung stereotactic body radiotherapy (SBRT). Thirty-eight plans were generated using the AXB-Dm in Eclipse Treatment Planning System (TPS) and then recalculated with the AXB-Dw and AAA, using identical beam setup. A dose of 50 Gy in 4 fractions was prescribed to the isocenter and the planning target volume (PTV) D95%...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297341/assessment-of-monte-carlo-algorithm-for-compliance-with-rtog-0915-dosimetric-criteria-in-peripheral-lung-cancer-patients-treated-with-stereotactic-body-radiotherapy
#6
Damodar Pokhrel, Sumit Sood, Rajeev Badkul, Hongyu Jiang, Christopher McClinton, Christopher Lominska, Parvesh Kumar, Fen Wang
The purpose of the study was to evaluate Monte Carlo-generated dose distributions with the X-ray Voxel Monte Carlo (XVMC) algorithm in the treatment of peripheral lung cancer patients using stereotactic body radiotherapy (SBRT) with non-protocol dose-volume normalization and to assess plan outcomes utilizing RTOG 0915 dosimetric compliance criteria. The Radiation Therapy Oncology Group (RTOG) protocols for non-small cell lung cancer (NSCLC) currently require radiation dose to be calculated using tissue density heterogeneity corrections...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297307/development-and-evaluation-of-a-clinical-model-for-lung-cancer-patients-using-stereotactic-body-radiotherapy-sbrt-within-a-knowledge-based-algorithm-for-treatment-planning
#7
Karen Chin Snyder, Jinkoo Kim, Anne Reding, Corey Fraser, James Gordon, Munther Ajlouni, Benjamin Movsas, Indrin J Chetty
The purpose of this study was to describe the development of a clinical model for lung cancer patients treated with stereotactic body radiotherapy (SBRT) within a knowledge-based algorithm for treatment planning, and to evaluate the model performance and applicability to different planning techniques, tumor locations, and beam arrangements. 105 SBRT plans for lung cancer patients previously treated at our institution were included in the development of the knowledge-based model (KBM). The KBM was trained with a combination of IMRT, VMAT, and 3D CRT techniques...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297281/a-survey-on-table-tolerances-and-couch-overrides-in-radiotherapy
#8
Bonnie Chinsky, Rakesh Patel, Joshua Panfil, Murat Surucu, John C Roeske
The purpose of this study was to survey current departmental policies on treatment couch overrides and the values of table tolerances used clinically. A 25-question electronic survey on couch overrides and tolerances was sent to full members of the American Association of Physicists in Medicine (AAPM). The first part of the survey asked participants if table overrides were allowed at their institution, who was allowed to perform these overrides, and if imaging was required with overrides. The second part of the survey asked individuals to provide table tolerance data for the following treatment sites: brain/head and neck (H&N), lung, breast, abdomen/pelvis and prostate...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296314/effect-of-the-normalized-prescription-isodose-line-on-the-magnitude-of-monte-carlo-vs-pencil-beam-target-dose-differences-for-lung-stereotactic-body-radiotherapy
#9
Dandan Zheng, Qinghui Zhang, Xiaoying Liang, Xiaofeng Zhu, Vivek Verma, Shuo Wang, Sumin Zhou
In lung stereotactic body radiotherapy (SBRT) cases, the pencil beam (PB) dose calculation algorithm is known to overestimate target dose as compared to the more accurate Monte Carlo (MC) algorithm. We investigated whether changing the normalized prescription isodose line affected the magnitude of MC vs. PB target dose differences. Forty-eight patient plans and twenty virtual-tumor phantom plans were studied. For patient plans, four alternative plans prescribed to 60%, 70%, 80%, and 90% isodose lines were each created for 12 patients who previously received lung SBRT treatments...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28285694/sbrt-for-oligoprogressive-oncogene-addicted-nsclc
#10
REVIEW
L Basler, S G C Kroeze, M Guckenberger
Lung cancer is one of the leading causes of cancer death in men and women and treatment outcome continues to lag behind other common cancer types. A subset of lung adenocarcinoma patients exhibit a somatic mutation in EGFR or an ALK rearrangement. In these patients, targeted TKI therapy results in higher response rates, improved PFS and reduced side effects compared with platinum-based chemotherapy. Despite initial activity of the TKIs, ultimately all patients present with disease progression after about a year on TKI therapy due to resistance development...
April 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28273349/a-radiobiological-model-of-reoxygenation-and-fractionation-effects
#11
Mariana Guerrero, David J Carlson
PURPOSE: To develop a radiobiological model of reoxygenation that fulfills the following goals.: 1 Quantify the reoxygenation effect for different fractionations. 2 Model the hypoxic fraction in tumors as a function of the number of radiation treatments. 3 Develop a simple analytical expression for a reoxygenation term in biological effect calculations. METHOD: The model considers tumor cells in two compartments: an aerobic (or normoxic) population of cells and a hypoxic population including cells under a range of reduced oxygen concentrations...
March 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28273341/still-equivalent-for-dose-calculation-in-the-monte-carlo-era-a-comparison-of-free-breathing-and-average-intensity-projection-ct-datasets-for-lung-sbrt-using-three-generations-of-dose-calculation-algorithms
#12
Kristina Zvolanek, Rongtao Ma, Christina Zhou, Xiaoying Liang, Shuo Wang, Vivek Verma, Xiaofeng Zhu, Qinghui Zhang, Joseph Driewer, Chi Lin, Weining Zhen, Andrew Wahl, Su-Min Zhou, Dandan Zheng
PURPOSE: Inhomogeneity dose modeling and respiratory motion description are two critical technical challenges for lung stereotactic body radiotherapy, an important treatment modality for small size primary and secondary lung tumors. Recent studies revealed lung density-dependent target dose differences between Monte Carlo (Type-C) algorithm and earlier algorithms. Therefore, this study aimed to investigate the equivalence of the two most popular CT datasets for treatment planning, free breathing (FB) and average intensity projection (AIP) CTs, using Type-C algorithms, and comparing with two older generation algorithms (Type-A and Type-B)...
March 8, 2017: Medical Physics
https://www.readbyqxmd.com/read/28270731/guideline-for-radiotherapy-with-curative-intent-in-patients-with-early-stage-medically-inoperable-non-small-cell-lung-cancer
#13
C B Falkson, E T Vella, E Yu, M El-Mallah, R Mackenzie, P M Ellis, Y C Ung
OBJECTIVES: For this guideline, we investigated the effectiveness of radiotherapy with curative intent in medically inoperable patients with early-stage non-small-cell lung cancer (nsclc). METHODS: The guideline was developed by Cancer Care Ontario's Program in Evidence-Based Care and by the Lung Cancer Disease Site Group through a systematic review of mainly retrospective studies, expert consensus, and formal internal and external reviews. RECOMMENDATIONS: ■ Stereotactic body radiation therapy (sbrt) with curative intent is an option that should be considered for patients with early-stage, node-negative, medically inoperable nsclc...
February 2017: Current Oncology
https://www.readbyqxmd.com/read/28266166/prognositc-significance-of-suvmax-on-pretreatment-18-f-fdg-pet-ct-in-early-stage-non-small-cell-lung-cancer-treated-with-stereotactic-body-radiotherapy-a-meta-analysis
#14
Min Dong, Jing Liu, Xiaorong Sun, Ligang Xing
INTRODUCTION: The prognostic importance of the (18) F-FDG PET maximum standardized uptake value (SUVmax ) for early stage non-small cell lung cancer (NSCLC) patients receiving stereotactic body radiotherapy (SBRT) is not well defined. The purpose of this meta-analysis is to evaluate the efficacy of SUVmax on pretreatment (18) F-FDG PET imaging to predict prognosis after SBRT. METHODS: All published English-language studies that assessed the treatment response after SBRT in patients with early-stage NSCLC using (18) F-FDG PET were collected from the EMBASE and MEDLINE databases...
March 7, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28258901/stereotactic-body-radiation-therapy-in-octo-and-nonagenarians-for-the-treatment-of-early-stage-lung-cancer
#15
Meredith Giuliani, Andrew Hope, Matthias Guckenberger, Frederick Mantel, Heike Peulen, Jan-Jakob Sonke, José Belderbos, Maria Werner-Wasik, Hong Ye, Inga S Grills
PURPOSE: To determine the safety and efficacy of lung stereotactic body radiation therapy (SBRT) in octo- and nonagenarians and to compare their outcomes with those of younger patients. METHODS AND MATERIALS: Patients with primary lung cancer treated with SBRT were identified from a multi-institutional (5 institutions) database of 1083 cases. Details of patient factors, treatment specifics, toxicity, and clinical outcomes were extracted from the database. All events were calculated from the end of radiation therapy...
January 9, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28244414/influence-of-fractionation-scheme-and-tumor-location-on-toxicities-after-stereotactic-body-radiation-therapy-for-large-%C3%A2-5-cm-non-small-cell-lung-cancer-a-multi-institutional-analysis
#16
Vivek Verma, Valerie K Shostrom, Weining Zhen, Mutian Zhang, Steve E Braunstein, John Holland, Christopher L Hallemeier, Matthew M Harkenrider, Adrian Iskhanian, Salma K Jabbour, Albert Attia, Percy Lee, Kyle Wang, Roy H Decker, Ronald C McGarry, Charles B Simone
PURPOSE: To describe the impact of fractionation scheme and tumor location on toxicities in stereotactic body radiation therapy (SBRT) for ≥5-cm non-small cell lung cancer (NSCLC), as part of a multi-institutional analysis. METHODS: Patients with primary ≥5-cm N0 M0 NSCLC who underwent ≤5-fraction SBRT were examined across multiple high-volume SBRT centers. Collected data included clinical/treatment parameters; toxicities were prospectively assessed at each institution according to the Common Terminology Criteria for Adverse Events...
March 15, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28242140/mri-guided-lung-sbrt-present-and-future-developments
#17
REVIEW
Martin J Menten, Andreas Wetscherek, Martin F Fast
Stereotactic body radiotherapy (SBRT) is rapidly becoming an alternative to surgery for the treatment of early-stage non-small cell lung cancer patients. Lung SBRT is administered in a hypo-fractionated, conformal manner, delivering high doses to the target. To avoid normal-tissue toxicity, it is crucial to limit the exposure of nearby healthy organs-at-risk (OAR). Current image-guided radiotherapy strategies for lung SBRT are mostly based on X-ray imaging modalities. Although still in its infancy, magnetic resonance imaging (MRI) guidance for lung SBRT is not exposure-limited and MRI promises to improve crucial soft-tissue contrast...
February 24, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28238577/geometrical-and-dosimetrical-uncertainties-in-hypofractionated-radiotherapy-of-the-lung-a-review
#18
REVIEW
Marco Schwarz, Giovanni Mauro Cattaneo, Livia Marrazzo
The application of high precision hypofractionated regimes (a.k.a. stereotactic body radiotherapy (SBRT)) to the treatment of lung cancer is a 'success story' of radiotherapy. From the technical perspective, lung SBRT is a challenging technique as all aspects of the treatment workflow, from imaging to dose calculation to treatment delivery, should be carefully handled in order to ensure consistency between planned and delivered dose. In this review such technical aspects are presented and discussed, looking at what has been developed over the years...
February 23, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28215851/a-novel-neoadjuvant-therapy-for-operable-locally-invasive-non-small-cell-lung-cancer-phase-i-study-of-neoadjuvant-stereotactic-body-radiotherapy-linnearre-i-nct02433574
#19
Nhu-Tram A Nguyen, Naghmeh Isfahanian, Gregory Pond, Wael Hanna, Jean-Claude Cutz, James Wright, Anand Swaminath, Yaron Shargall, Tom Chow, Marcin Wierzbicki, Gordon Okawara, Kimmen Quan, Christian Finley, Rosalyn Juergens, Theodoros Tsakiridis
BACKGROUND: Despite improved staging and surgical techniques, the rate of incomplete resection (R1) of non-small-cell lung cancer (NSCLC) has not significantly decreased. Patients with R1 resection have worse survival compared with those with complete resection (R0). Stereotactic body radiotherapy (SBRT) is a rapid and convenient radiotherapy treatment that delivers high-dose radiotherapy to tumors with high precision while sparing normal organs. Although its efficacy in treating small lung tumors is documented, its use as neoadjuvant therapy for locally advanced (LA) NSCLC has not been examined...
January 31, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/28195507/predicting-risk-factors-for-radiation-pneumonitis-after-stereotactic-body-radiation-therapy-for-primary-or-metastatic-lung-tumors
#20
Mitsuru Okubo, Tomohiro Itonaga, Tatsuhiko Saito, Sachika Shiraishi, Ryuji Mikami, Hidetugu Nakayama, Akira Sakurada, Shinji Sugahara, Kiyoshi Koizumi, Koichi Tokuuye
OBJECTIVES: To investigate risk factors for radiation-induced pneumonitis (RP) after hypofractionated stereotactic body radiotherapy (SBRT) in patients with lung tumors. METHODS: From May 2004 to January 2016, 66 patients with 71 primary or metastatic lung tumors were treated with SBRT; these 71 cases were retrospectively analyzed for RP. To explore the risk factors for RP, the following factors were investigated: age, sex, performance status, operability, number of treatments, respiratory gating, pulmonary emphysema, tumor location, and subclinical interstitial lung disease (ILD)...
February 14, 2017: British Journal of Radiology
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