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Lung SBRT

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https://www.readbyqxmd.com/read/27912764/sbrt-for-centrally-localized-nsclc-what-is-too-central
#1
J Roesch, C Panje, F Sterzing, F Mantel, U Nestle, N Andratschke, M Guckenberger
PURPOSE: Current guidelines recommend stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer (NSCLC) in medically inoperable patients. There are excellent outcome and toxicity data for SBRT of peripheral lung tumors. However, the discussion on SBRT for centrally located tumors is controversial. This study evaluated current clinical practice regarding SBRT of centrally located lung tumors, to identify common fractionation schedules and commonly accepted contraindications for SBRT...
December 3, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27908621/radiotherapy-with-curative-intent-in-patients-with-early-stage-medically-inoperable-non-small-cell-lung-cancer-a-systematic-review
#2
REVIEW
Conrad B Falkson, Emily T Vella, Edward Yu, Medhat El-Mallah, Robert Mackenzie, Peter M Ellis, Yee C Ung
Patients with early-stage non-small-cell lung cancer (NSCLC) who are unable to undergo surgery can be offered radiation therapy (RT). Previously, conventional RT was offered; however, newer techniques such as stereotactic body RT (SBRT) have become available. The objective of the present systematic review was to investigate the effectiveness of RT with curative intent in patients with early-stage medically inoperable NSCLC. MEDLINE, EMBASE, and the Cochrane Library were searched for studies comparing stereotactic RT with curative intent compared with observation or other types of RT for early-stage, medically inoperable, NSCLC...
October 27, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27908620/location-matters-stage-i-non-small-cell-carcinomas-of-the-lower-lobes-treated-with-stereotactic-body-radiation-therapy-are-associated-with-poor-outcomes
#3
Narek Shaverdian, Darlene Veruttipong, Jason Wang, Patrick Kupelian, Michael Steinberg, Percy Lee
INTRODUCTION: The lung is a heterogeneous organ with relative overperfusion of the lung bases. We determined whether a lower lobe primary tumor location was associated with poor outcomes in the setting of stage I non-small-cell lung cancer (NSCLC) treated with stereotactic body radiation therapy (SBRT). PATIENTS AND METHODS: The data from consecutive patients with stage I NSCLC treated from 2009 to 2014 with curative intent SBRT were analyzed. Primary tumors in the right and left lower lobes were compared against the tumors in all other locations to determine whether a lower lobe location was associated with worse local, regional, and distant control and worse relapse-free and overall survival...
October 28, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27890568/dose-calculation-algorithm-accuracy-for-small-fields-in-non-homogeneous-media-the-lung-sbrt-case
#4
REVIEW
Antonella Fogliata, Luca Cozzi
This review addresses the theme of dose calculation accuracy in the case of the stereotactic treatment of lung lesions. Based on the classical categories of type "a", "b" and "c" algorithms (according to their degree of complexity in the management of charged particle transport), a summary of findings from literature is reported. Two main critical areas have been identified: the use of small fields and the presence of low density medium. Concerning the latter point, the algorithm accuracy is intrinsic of the algorithm core, and, notwithstanding the materials discretization and their chemical composition knowledge, type "c" are, at the most, able to reproduce the actual physical dose distribution in heterogeneous media...
November 24, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27876604/predictors-and-patterns-of-regional-recurrence-following-lung-sbrt-a-report-from-the-elekta-lung-research-group
#5
Meredith E Giuliani, Andrew Hope, Victor Mangona, Matthias Guckenberger, Frederick Mantel, Heike Peulen, Jan-Jakob Sonke, José Belderbos, Maria Werner-Wasik, Hong Ye, Inga S Grills
INTRODUCTION: The objective of this study was to determine the predictors and patterns of regional recurrence (RR) following stereotactic body radiotherapy (SBRT) for primary lung cancers. MATERIAL AND METHODS: Details of patient factors, treatment, and outcome factors were extracted from a multi-institutional (5) database. All events were calculated from the end of radiotherapy. Estimates of local recurrence, RR, and distant metastases (DM) were calculated using the competing risk method...
October 26, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27876603/canadian-phase-iii-randomized-trial-of-stereotactic-body-radiotherapy-versus-conventionally-hypofractionated-radiotherapy-for-stage-i-medically-inoperable-non-small-cell-lung-cancer-rationale-and-protocol-design-for-the-ontario-clinical-oncology-group-ocog
#6
Anand Swaminath, Marcin Wierzbicki, Sameer Parpia, James R Wright, Theodoros K Tsakiridis, Gordon S Okawara, Vijayananda Kundapur, Alexis Bujold, Naseer Ahmed, Khalid Hirmiz, Elizabeth Kurien, Edith Filion, Zsolt Gabos, Sergio Faria, Alexander V Louie, Timothy Owen, Elaine Wai, Kevin Ramchandar, Elisa K Chan, Jim Julian, Kathryn Cline, Timothy J Whelan
We describe a Canadian phase III randomized controlled trial of stereotactic body radiotherapy (SBRT) versus conventionally hypofractionated radiotherapy (CRT) for the treatment of stage I medically inoperable non-small-cell lung cancer (OCOG-LUSTRE Trial). Eligible patients are randomized in a 2:1 fashion to either SBRT (48 Gy in 4 fractions for peripherally located lesions; 60 Gy in 8 fractions for centrally located lesions) or CRT (60 Gy in 15 fractions). The primary outcome of the study is 3-year local control, which we hypothesize will improve from 75% with CRT to 87...
October 3, 2016: Clinical Lung Cancer
https://www.readbyqxmd.com/read/27871671/tumor-control-probability-modeling-for-stereotactic-body-radiation-therapy-of-early-stage-lung-cancer-using-multiple-bio-physical-models
#7
REVIEW
Feng Liu, An Tai, Percy Lee, Tithi Biswas, George X Ding, Isaam El Naqa, Jimm Grimm, Andrew Jackson, Feng-Ming Spring Kong, Tamara LaCouture, Billy Loo, Moyed Miften, Timothy Solberg, X Allen Li
This work is to analyze pooled clinical data using different radiobiological models and to understand the relationship between biologically effective dose (BED) and tumor control probability (TCP) for stereotactic body radiotherapy (SBRT) of early-stage non-small cell lung cancer (NSCLC). The clinical data of 1-, 2-, 3-, and 5-year actuarial or Kaplan-Meier TCP from 46 selected studies were collected for SBRT of NSCLC in the literature. The TCP data were separated for Stage T1 and T2 tumors if possible, otherwise collected for combined stages...
November 18, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27869080/the-effect-of-biologically-effective-dose-and-radiation-treatment-schedule-on-overall-survival-in-stage-i-non-small-cell-lung-cancer-patients-treated-with-stereotactic-body-radiation-therapy
#8
John M Stahl, Rudi Ross, Eileen M Harder, Brandon R Mancini, Pamela R Soulos, Steven E Finkelstein, Timothy D Shafman, Arie P Dosoretz, Suzanne B Evans, Zain A Husain, James B Yu, Cary P Gross, Roy H Decker
PURPOSE: To determine the effect of biologically effective dose (BED10) and radiation treatment schedule on overall survival (OS) in patients with early-stage non-small cell lung cancer (NSCLC) undergoing stereotactic body radiation therapy (SBRT). METHODS AND MATERIALS: Using data from 65 treatment centers in the United States, we retrospectively reviewed the records of T1-2 N0 NSCLC patients undergoing SBRT alone from 2006 to 2014. Biologically relevant covariates, including dose per fraction, number of fractions, and time between fractions, were used to quantify BED10 and radiation treatment schedule...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27846900/4dct-and-cbct-based-ptv-margin-in-stereotactic-body-radiotherapy-sbrt-of-non-small-cell-lung-tumor-adhered-to-chest-wall-or-diaphragm
#9
Yi Li, Jing-Lu Ma, Xin Chen, Feng-Wen Tang, Xiao-Zhi Zhang
BACKGROUND: Large tumor motion often leads to larger treatment volumes, especially the lung tumor located in lower lobe and adhered to chest wall or diaphragm. The purpose of this work is to investigate the impacts of planning target volume (PTV) margin on Stereotactic Body Radiotherapy (SBRT) in non-small cell lung cancer (NSCLC). METHODS: Subjects include 20 patients with the lung tumor located in lower lobe and adhered to chest wall or diaphragm who underwent SBRT...
November 15, 2016: Radiation Oncology
https://www.readbyqxmd.com/read/27843031/influence-of-institutional-experience-and-technological-advances-on-outcome-of-stereotactic-body-radiation-therapy-for-oligometastatic-lung-disease
#10
Juliane Rieber, Nasrin Abbassi-Senger, Sonja Adebahr, Nicolaus Andratschke, Oliver Blanck, Marciana Duma, Michael J Eble, Iris Ernst, Michael Flentje, Sabine Gerum, Peter Hass, Christoph Henkenberens, Guido Hildebrandt, Detlef Imhoff, Henning Kahl, Nathalie Desirée Klass, Robert Krempien, Fabian Lohaus, Frank Lohr, Cordula Petersen, Elsge Schrade, Jan Streblow, Lorenz Uhlmann, Andrea Wittig, Florian Sterzing, Matthias Guckenberger
PURPOSE: Many technological and methodical advances have made stereotactic body radiotherapy (SBRT) more accurate and more efficient during the last years. This study aims to investigate whether experience in SBRT and technological innovations also translated into improved local control (LC) and overall survival (OS). METHODS AND MATERIALS: A database of 700 patients treated with SBRT for lung metastases in 20 German centers between 1997 and 2014 was used for analysis...
September 26, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27843029/stereotactic-body-radiation-therapy-and-the-influence-of-chemotherapy-on-overall-survival-for-large-%C3%A2-5-centimeter-non-small-cell-lung-cancer
#11
Vivek Verma, Matthew T McMillan, Surbhi Grover, Charles B Simone
PURPOSE: Stereotactic body radiation therapy (SBRT) for ≥5 cm lesions is poorly defined, largely owing to the low sample sizes in existing studies. The present analysis examined the SBRT outcomes and assessed the effect of chemotherapy in this population. METHODS AND MATERIALS: The National Cancer Data Base was queried for primary non-small cell lung cancer ≥5 cm treated with SBRT (≤10 fractions). Patient, tumor, and treatment parameters were extracted. The primary outcome was overall survival (OS)...
September 29, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27819875/clinical-outcomes-after-lung-stereotactic-body-radiation-therapy-in-patients-with-or-without-a-prior-lung-resection
#12
Ying Hou, Gretchen Hermann, John H Lewis, Hugo J Aerts, Elizabeth H Baldini, Aileen B Chen, Yolonda L Colson, Fred L Hacker, Joseph H Killoran, David E Kozono, Matthew Wagar, Jon O Wee, Raymond H Mak
OBJECTIVES: Tumor control (TC), toxicity and survival, following stereotactic body radiation therapy (SBRT) were compared between patients with and without a prior lung resection (PLR). MATERIALS AND METHODS: The study is comprised of 130 patients with 141 peripheral tumors treated with SBRT at our institution from 2009 to 2013. Primary TC and lobar control (LC) were defined per RTOG 0236. Toxicity was scored using Common Terminology Criteria for Adverse Events version 4...
November 4, 2016: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27806589/real-time-4d-dose-reconstruction-for-tracked-dynamic-mlc-deliveries-for-lung-sbrt
#13
Cornelis Ph Kamerling, Martin F Fast, Peter Ziegenhein, Martin J Menten, Simeon Nill, Uwe Oelfke
PURPOSE: This study provides a proof of concept for real-time 4D dose reconstruction for lung stereotactic body radiation therapy (SBRT) with multileaf collimator (MLC) tracking and assesses the impact of tumor tracking on the size of target margins. METHODS: The authors have implemented real-time 4D dose reconstruction by connecting their tracking and delivery software to an Agility MLC at an Elekta Synergy linac and to their in-house treatment planning software (TPS)...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27805837/dosimetric-factors-predicting-radiation-pneumonitis-after-cyberknife-stereotactic-body-radiotherapy-for-peripheral-lung-cancer
#14
Masaki Nakamura, Hideki Nishimura, Masao Nakayama, Hiroshi Mayahara, Haruka Uezono, Aya Harada, Naoki Hashimoto, Yasuo Ejima, Takeaki Ishihara, Ryohei Sasaki
OBJECTIVE: The aims of this study were to investigate the frequency of symptomatic radiation pneumonitis (RP) after CyberKnife lung stereotactic body radiotherapy (SBRT) and to evaluate predictive factors of symptomatic RP. METHODS: 56 patients with peripheral non-small-cell lung cancer were treated using the CyberKnife(®) VSI(™) System (Accuracy Inc., Sunnyvale, CA) between May 2013 and September 2015. Total radiation doses ranged from 48 to 56 Gy, as delivered in four equal fractions...
December 2016: British Journal of Radiology
https://www.readbyqxmd.com/read/27798931/radiation-pneumonitis-changes-over-time-after-stereotactic-body-radiation-therapy-for-lung-tumors-post-treatment-cavity-sunny-side-up-egg-like-changes
#15
Toshiya Maebayashi, Naoya Ishibashi, Takuya Aizawa, Masakuni Sakaguchi, Tsutomu Sato, Jiro Kawamori, Yoshiaki Tanaka
BACKGROUND: Stereotactic body radiation therapy (SBRT) is a viable treatment option for stage I non-small cell lung carcinoma (NSCLC) in non-surgical candidates. Although treatment with a 100 Gy biological effective dose is considered to carry a low risk of local recurrence, only a few reports have focused on changes in tumors or surrounding intact portions of the lung after SBRT. Such changes are assessed using diagnostic imaging specifically for radiation pneumonitis, which can be difficult to distinguish from local tumor recurrence...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27798905/non-small-cell-lung-cancer-nsclc-in-octogenarians-in-clinical-practice
#16
Hirsh Koyi, Gunnar Hillerdal, Karl-Gustav Kölbeck, Daniel Brodin, Per Liv, Eva Brandén
BACKGROUND/AIM: Globally, an increasing proportion of cancer patients are aged >65 years and many are aged >70 years. Treatment of the elderly with lung cancer has, therefore, become an important issue. We performed a retrospective study of our patients to demonstrate how octogenarians with non-small cell lung cancer (NSCLC) are treated in real-life clinical practice. PATIENTS AND METHODS: This was a retrospective observational study of all elderly (≥80 years) patients with NSCLC referred to the Department of Respiratory Medicine and Allergy, Karolinska Hospital, Sweden, 2003-2010, and followed until June, 2016...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27787380/is-surgery-indicated-for-elderly-patients-with-early-stage-nonsmall-cell-lung-cancer-in-the-era-of-stereotactic-body-radiotherapy
#17
Nam P Nguyen, Juan Godinez, Wei Shen, Vincent Vinh-Hung, Helena Gorobets, Juliette Thariat, Fred Ampil, Jacqueline Vock, Ulf Karlsson, Alexander Chi
BACKGROUND: The aim of this article is to assess the influence of comorbidities among elderly patients (at least 70 year old) undergoing surgery for early stage nonsmall cell lung cancer (NSCLC) and to explore the tolerability and efficacy of surgery in relation to stereotactic body radiotherapy (SBRT) in this patient population. METHODS: A review of the literature on the prevalence of comorbidities among elderly patients with early stage NSCLC, and the impact of comorbidity factors on survival following surgery was conducted...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27782711/the-effect-of-density-variation-on-photon-dose-calculation-and-its-impact-on-intensity-modulated-radiotherapy-and-stereotactic-body-radiotherapy
#18
Qiang Liu, Jian Liang, Carl W Stanhope, Di Yan
PURPOSE: Inaccurate density information may introduce dose calculation errors when inhomogeneity correction is applied. The aim of the present study was to examine the effect of density variation on photon dose calculation accuracy using the convolution/superposition (CS) algorithm with the focus on newer treatment technologies including intensity modulated radiotherapy, volumetric modulated arc radiotherapy, and stereotactic body radiotherapy (SBRT). METHODS: Calculations were first performed using simple inhomogeneity phantoms in order to determine clinically relevant tolerance levels for different tissue types...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27782698/a-pencil-beam-dose-calculation-model-for-cyberknife-system
#19
Bin Liang, Yongbao Li, Bo Liu, Fugen Zhou, Shouping Xu, Qiuwen Wu
PURPOSE: CyberKnife system is initially equipped with fixed circular cones for stereotactic radiosurgery. Two dose calculation algorithms, Ray-Tracing and Monte Carlo, are available in the supplied treatment planning system. A multileaf collimator system was recently introduced in the latest generation of system, capable of arbitrarily shaped treatment field. The purpose of this study is to develop a model based dose calculation algorithm to better handle the lateral scatter in an irregularly shaped small field for the CyberKnife system...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27751617/single-fraction-flattening-filter-free-volumetric-modulated-arc-therapy-for-lung-cancer-dosimetric-results-and-comparison-with-flattened-beams-technique
#20
Sara Barbiero, Alexandra Rink, Fabrizio Matteucci, David Fedele, Fabiola Paiar, Francesco Pasqualetti, Michele Avanzo
PURPOSE: To report on single-fraction stereotactic body radiotherapy (RT) (SBRT) with flattening filter (FF)-free (FFF) volumetric modulated arc therapy (VMAT) for lung cancer and to compare dosimetric results with VMAT with FF. METHODS AND MATERIALS: Overall, 25 patients were treated with 6-MV FFF VMAT (Varian TrueBeam STx LINAC) to a prescribed dose of 24Gy in a single fraction. Treatment plans were recreated using FF VMAT. Dose-volume indices, monitor units (MU), and treatment times were compared between FFF and FF VMAT techniques...
October 14, 2016: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
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