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https://www.readbyqxmd.com/read/28446645/hypothalamus-as-a-mediator-of-chronic-migraine-evidence-from-high-resolution-fmri
#1
Laura H Schulte, Angie Allers, Arne May
OBJECTIVE: To identify pathophysiologic mechanisms of migraine chronification using a recently standardized protocol for high-resolution brainstem imaging of trigeminal nociceptive stimulation. METHODS: Eighteen episodic migraineurs (EMs), 17 chronic migraineurs (CMs), and 19 healthy controls (HCs) underwent painful ammonia stimulation of the left nostril in a 3T MRI scanner. Functional images were acquired with a brainstem-optimized protocol for high-resolution echo-planar imaging...
April 26, 2017: Neurology
https://www.readbyqxmd.com/read/28442975/ultrasound-guided-trigeminal-nerve-block-for-faciomaxillary-surgeries
#2
Amarjeet Kumar, Ajeet Kumar, Chandni Sinha, Akhilesh Kumar Singh
No abstract text is available yet for this article.
April 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28442409/sinonasal-mucosal-melanoma-a-44-case-study-and-literature-analysis
#3
M Dréno, M Georges, F Espitalier, C Ferron, A Charnolé, B Dréno, O Malard
OBJECTIVES: Sinonasal mucosal melanoma is a rare disease, representing 4% of nasal cavity and paranasal sinus malignancies. The aim of this study was to assess the clinical characteristics, progression and treatment of this disease and to identify prognostic factors. MATERIAL AND METHODS: This retrospective review presents a cohort of 44 patients treated for a melanoma arising from the nasal cavity and paranasal sinuses, in the ENT Head and Neck Surgery Department of the University Hospital of Nantes (France) between 1988 and 2015...
April 22, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28440673/mechanisms-of-craniofacial-pain
#4
Juliana Geremias Chichorro, Frank Porreca, Barry Sessle
Aim To provide an overview of mechanisms underlying craniofacial pain; to highlight peripheral and central adaptations that may promote chronification of pain in craniofacial pain states such as migraine and temporomandibular disorders (TMD). Background Pain is a common symptom associated with disorders involving craniofacial tissues including the teeth and their supporting structures, the temporomandibular joint and the muscles of the head. Most acute painful craniofacial conditions are easily recognized and well managed, but others, especially those that are chronic (e...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28439158/trigemino-cardiac-reflex-a-phenomenon-neglected-in-maxillofacial-surgery
#5
Udupikrishna M Joshi, Ashwini Munnangi, Kundan Shah, Satishkumar G Patil, Nitin Thakur
BACKGROUND: Trigemino-cardiac reflex is a physiologic response of the body to pressure effects in the region of distribution of the trigeminal nerve. Oral and maxillofacial surgical procedures can induce the development of this reflex, which leads to significant changes in the heart rate and sinus rhythms. This study intends to evaluate the effects of this reflex in patients with facial fractures and its subsequent management. PATIENTS AND METHODS: A total of thirty-seven patients with facial fractures who reported to the Department of Oral and Maxillofacial Surgery at Basaveswar Teaching and General Hospital, Gulbarga during a period from July 2015-March 2016 were considered for the study...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28439155/extracranial-trigeminal-schwannomas-a-retrospective-analysis
#6
Aviral Agrawal, Virendra Singh, Amrish Bhagol, Pradeep Kumar, Anjali Narwal
OBJECTIVE: To analyse the clinic-radiological features and treatment outcome of extracranial trigeminal schwannomas. METHOD: Medical records and radiographs of patients treated, from January 2011 to December 2013, for neurogenic tumors were retrospectively reviewed. Extracranial schwannomas other than those of trigeminal nerve were also excluded. A number of parameters, including the patient's age, gender, site, clinical features, radiographic features, histologic variants and treatment provided as well as any associated complications were recorded and analysed...
June 2017: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/28437509/thermal-perception-as-a-key-factor-for-assessing-effects-of-trigeminal-nerve-injury
#7
Hye-Kyoung Kim, Ki-Suk Kim, Mee-Eun Kim
AIMS: To conduct a functional examination using multimodal exploration of a sample of patients with iatrogenic trigeminal nerve injury to understand the underlying mechanisms of neuropathic pain following trigeminal nerve injury. METHODS: Subjective and objective symptoms and responses to thermal and electrical quantitative sensory testing (QST) were evaluated in 85 patients with unilateral trigeminal nerve injury. Objective symptoms were measured by seven clinical sensory tests...
April 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28435111/meta-analysis-on-safety-and-efficacy-of-microsurgical-and-radiosurgical-treatment-of-trigeminal-neuralgia
#8
REVIEW
Arthur Gubian, Steffen K Rosahl
No abstract text is available yet for this article.
April 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28434965/trochlear-schwannoma-presenting-with-isolated-trigeminal-neuralgia
#9
Cody L Nesvick, Avital Perry, Christopher S Graffeo, Aditya Raghunathan, Julie E Hammack, Jamie J Van Gompel
BACKGROUND: Schwannomas arising from the cranial nerves controlling extraocular eye movements are very rare and usually present with some degree of diplopia. CASE DESCRIPTION: We report a 50-year-old woman who presented with isolated left-sided trigeminal neuralgia of six months' duration. Imaging demonstrated a homogeneously enhancing mass in the left ambient cistern, and the patient was taken to the operating room for resection. A retrosigmoid approach was used, and the mass was directly visualized arising from the trochlear nerve and compressing on the dorsal root entry zone of the trigeminal nerve...
April 18, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28432602/sphenopalatine-ganglion-block-in-the-management-of-chronic-headaches
#10
REVIEW
Jeffery Mojica, Bi Mo, Andrew Ng
PURPOSE OF REVIEW: Sphenopalatine ganglion (SPG) block has been used by clinicians in the treatment of a variety of headache disorders, facial pain syndromes, and other facial neuralgias. The sensory and autonomic fibers that travel through the SPG provided the scientific rationale for symptoms associated with these head and neck syndromes. Yet, despite the elucidation of this pathogenic target, the optimal method to block its pain-producing properties has not been determined. Clinicians have developed various invasive and non-invasive techniques, each of which has shown variable rates of success...
June 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28430869/inhibition-of-the-p2x7-panx1-complex-suppresses-spreading-depolarization-and-neuroinflammation
#11
Shih-Pin Chen, Tao Qin, Jessica L Seidel, Yi Zheng, Matthias Eikermann, Michel D Ferrari, Arn M J M van den Maagdenberg, Michael A Moskowitz, Cenk Ayata, Katharina Eikermann-Haerter
Spreading depolarization is a wave of neuronal and glial depolarization. Within minutes after spreading depolarization, the neuronal hemichannel pannexin 1 (PANX1) opens and forms a pore complex with the ligand-gated cation channel P2X7, allowing the release of excitatory neurotransmitters to sustain spreading depolarization and activate neuroinflammation. Here, we explore the hypothesis that the P2X7-PANX1 pore complex is a critical determinant of spreading depolarization susceptibility with important consequences for neuroinflammation and trigeminovascular activation...
April 20, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28430860/increased-brainstem-perfusion-but-no-blood-brain-barrier-disruption-during-attacks-of-migraine-with-aura
#12
Anders Hougaard, Faisal M Amin, Casper E Christensen, Samaira Younis, Frauke Wolfram, Stig P Cramer, Henrik B W Larsson, Messoud Ashina
The migraine aura is characterized by transient focal cortical disturbances causing dramatic neurological symptoms that are usually followed by migraine headache. It is currently not understood how the aura symptoms are related to the headache phase of migraine. Animal studies suggest that cortical spreading depression, the likely mechanism of migraine aura, causes disruption of the blood-brain barrier and noxious stimulation of trigeminal afferents leading to activation of brainstem nuclei and triggering of migraine headache...
April 18, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28430035/noninvasive-neuromodulation-and-thalamic-mapping-with-low-intensity-focused-ultrasound
#13
Robert F Dallapiazza, Kelsie F Timbie, Stephen Holmberg, Jeremy Gatesman, M Beatriz Lopes, Richard J Price, G Wilson Miller, W Jeffrey Elias
OBJECTIVE Ultrasound can be precisely focused through the intact human skull to target deep regions of the brain for stereotactic ablations. Acoustic energy at much lower intensities is capable of both exciting and inhibiting neural tissues without causing tissue heating or damage. The objective of this study was to demonstrate the effects of low-intensity focused ultrasound (LIFU) for neuromodulation and selective mapping in the thalamus of a large-brain animal. METHODS Ten Yorkshire swine ( Sus scrofa domesticus) were used in this study...
April 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28429608/two-times-of-trigeminal-neuralgia-resolution-following-hydrocephalus-treatment-in-a-patient-with-a-high-voltage-electric-shock-to-his-head-a-case-report-and-a-review-of-the-literature
#14
Seyed Mohammad Ghodsi, Mahdi Safdarian
Hydrocephalus has rarely been reported to be associated with trigeminal neuralgia. Here we report for the first time a case of trigeminal neuralgia associated with hydrocephalus, whose symptoms completely resolved twice after ventriculoperitoneal shunting. The patient had a high-voltage electric shock to his head, which has not been reported in a patient with ventriculoperitoneal shunt to the best of our knowledge. The possible underlying mechanism of this situation is discussed in addition to a brief review of the literature...
April 21, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28426550/neuropathic-pain-after-chronic-nerve-constriction-may-not-correlate-with-chloride-dysregulation-in-mouse-trigeminal-nucleus-caudalis-neurons
#15
Alberto Castro, Ying Li, Charles Raver, Ramesh Chandra, Radi Masri, Mary Kay Lobo, Asaf Keller
Changes in chloride reversal potential in rat spinal cord neurons have previously been associated with persistent pain in nerve injury and inflammation models. These changes correlate with a decrease in the expression of the potassium% chloride transporter, KCC2, and with increases in neuronal excitability. Here, we test the hypothesis that similar changes occur in mice with neuropathic pain induced by chronic constriction injury of the trigeminal infraorbital nerve (CCI¬-ION). This model allows us to distinguish an acute pain phase (3-¬5 days after injury) from a persistent pain phase (12¬-14 days after CCI-¬ION)...
April 18, 2017: Pain
https://www.readbyqxmd.com/read/28425324/persistent-idiopathic-facial-pain
#16
Rafael Benoliel, Charly Gaul
Background Persistent idiopathic facial pain (PIFP) is a chronic disorder recurring daily for more than two hours per day over more than three months, in the absence of clinical neurological deficit. PIFP is the current terminology for Atypical Facial Pain and is characterized by daily or near daily pain that is initially confined but may subsequently spread. Pain cannot be attributed to any pathological process, although traumatic neuropathic mechanisms are suspected. When present intraorally, PIFP has been termed 'Atypical Odontalgia', and this entity is discussed in a separate article in this special issue...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28425266/nitroglycerin-challenge-induces-lateralized-headache-in-nasociliarynerve-ligated-rats-implications-for-chronic-migraine
#17
Didem Akçali, Ahmet Deniz Belen, Avni Babacan, Hayrunnisa Bolay
BACKGROUND/AIM: Chronic migraine is a common debilitating disease with limited treatment options. We aimed to develop a novel model for chronic migraine by ligating the nasociliary nerve (NCL) and administering nitroglycerin (NTG) to exacerbate acute headache attacks. MATERIALS AND METHODS: Exacerbation of the headache was induced by NTG (10 mg/kg, subcutaneously) administered to male Wistar rats (n = 36) 14 days following unilateral NCL. Cutaneous and cold allodynia was tested using Von Frey (VF) filaments and acetone, respectively...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28424990/proteomic-analysis-of-the-hippocampus-in-mouse-models-of-trigeminal-neuralgia-and-inescapable-shock-induced-depression
#18
Qing-Huan Guo, Qing-He Tong, Ning Lu, Hong Cao, Liu Yang, Yu-Qiu Zhang
To investigate the behavioral and biomolecular similarity between neuralgia and depression, a trigeminal neuralgia (TN) mouse model was established by constriction of the infraorbital nerve (CION) to mimic clinical trigeminal neuropathic pain. A mouse learned helplessness (LH) model was developed to investigate inescapable foot-shock-induced psychiatric disorders like depression in humans. Mass spectrometry was used to assess changes in the biomolecules and signaling pathways in the hippocampus from TN or LH mice...
April 19, 2017: Neuroscience Bulletin
https://www.readbyqxmd.com/read/28424485/in-vivo-dynamics-of-aav-mediated-gene-delivery-to-sensory-neurons-of-the-trigeminal-ganglia
#19
Chung H Dang, Martine Aubert, Harshana S De Silva Feelixge, Kurt Diem, Michelle A Loprieno, Pavitra Roychoudhury, Daniel Stone, Keith R Jerome
The ability to genetically manipulate trigeminal ganglion (TG) neurons would be useful in the study of the craniofacial nervous system and latent alphaherpesvirus infections. We investigated adeno-associated virus (AAV) vectors for gene delivery to the TG after intradermal whiskerpad delivery in mice. We demonstrated that AAV vectors of serotypes 1, 7, 8, and 9 trafficked from the whiskerpad into TG neurons and expressed transgenes within cell bodies and axons of sensory neurons in all three branches of the TG...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28421829/hydrocephalus-and-trigeminal-neuralgia-exploring-the-association-and-management-options
#20
Yuuki Charlie Barke Na, Shyam Vijay Pujara, Ahmad Abdelhai Moussa, Amy Charlotte Gerrish, Surajit Basu
We report the successful surgical management of three patients with trigeminal neuralgia and hydrocephalus. MRI revealed no neurovascular contact at the trigeminal root entry zone. Trigeminal neuralgic symptoms were controlled following alleviation of hydrocephalus. We hypothesize that trigeminal nerve traction, secondary to hydrocephalus, as the cause for their trigeminal neuralgia.
April 19, 2017: British Journal of Neurosurgery
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