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https://www.readbyqxmd.com/read/28931106/a-case-of-prethoracic-pain-radiating-upward-and-initiating-nervus-intermedius-neuralgia-and-migraine-headache-could-epicrania-fugax-pain-start-in-the-upper-body
#1
Yu Wang, Pei-Lin Kan, Yuan-Feng Tao, Xiao-Yan Li, Xiao-Juan Yang, Gui-Ling Liang
Epicrania fugax (EF) was recently classified as a primary headache in the Appendix of the International Classification of Headache Disorders, third edition (ICHD-III). It is characterized by a paroxysmal pain rapidly radiating forward or backward along a linear or zigzag trajectory on the surface of the head. This article reports a 76-year-old woman who newly developed a paroxysmal EF-type pain distributed not only in the territories of the trigeminal and occipital nerves, but also in the territories of the cervical and thoracic nerves...
September 20, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/28928638/affective-circuitry-alterations-in-patients-with-trigeminal-neuralgia
#2
Dave J Hayes, David Q Chen, Jidan Zhong, Ariel Lin, Brendan Behan, Matthew Walker, Mojgan Hodaie
Trigeminal neuralgia (TN) is a severe chronic neuropathic facial pain disorder. Affect-related behavioral and structural brain changes have been noted across chronic pain disorders, but have not been well-studied in TN. We examined the potential impact of TN (37 patients: 23 with right-sided TN, 14 with left-sided TN), compared to age- and sex-matched healthy controls, on three major white matter tracts responsible for carrying affect-related signals-i.e., cingulum, fornix, and medial forebrain bundle. Diffusion magnetic resonance imaging (dMRI), deterministic multi-tensor tractography for tract modeling, and a model-driven region-of-interest approach was used...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28927915/stereotactic-radiosurgery-for-type-1-versus-type-2-trigeminal-neuralgias
#3
Ching-Jen Chen, Gabriella Paisan, Thomas J Buell, Kristen Knapp, Dale Ding, Zhiyuan Xu, Daniel M Raper, Davis G Taylor, Robert F Dallapiazza, Cheng-Chia Lee, Jason P Sheehan
INTRODUCTION: It remains unclear whether if stereotactic radiosurgery (SRS) offers the same benefit for patients with type 2 trigeminal neuralgia (TN2) as for those with type 1 trigeminal neuralgia (TN1). The objective of this study is to compare the outcomes of patients with TN1 and TN2 following SRS. METHODS: SRS outcomes of trigeminal neuralgia patients treated at a single center from 1994 to 2016 were analyzed. Patients with TN1 were matched to those with TN2 in a 1:1 ratio based on sex, age, pre-treatment Barrow Neurological Institute (BNI) pain score, prior treatment, prior facial numbness, and maximum dose...
September 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28926781/a-leukomyeloencephalopathy-of-unknown-origin-in-an-azawakh-dog
#4
Maria Teresa Mandara, Alice Reginato, Federica Balducci, Marco Bernardini
A diffuse bilaterally symmetrical leukomyeloencephalopathy was observed in a 6-year-old male Azawakh dog showing a slowly progressive ataxia of six months duration associated with sensory disorders. Severe bilaterally symmetrical demyelination and vacuolisation were confined to the dorsal columns along the entire spinal cord with a minor axonal degeneration. The main changes of myelin sheaths consisted in splitting and intramyelin vacuolization. Naked axons were scattered in a network of astrocytic processes and collagen fibres...
September 5, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28925503/quantitative-analysis-of-mouse-dural-afferent-neurons-expressing-trpm8-vglut3-and-nf200
#5
Lynn Ren, Michelle Jaehee Chang, Zhiyu Zhang, Ajay Dhaka, Zhaohua Guo, Yu-Qing Cao
OBJECTIVE: To quantify the abundance of dural afferent neurons expressing transient receptor potential channel melastatin 8 (TRPM8), vesicular glutamate transporter 3 (VGLUT3), and neurofilament 200 (NF200) in adult mice. BACKGROUND: With the increasing use of mice as a model system to study headache mechanisms, it is important to understand the composition of dural afferent neurons in mice. In a previous study, we have measured the abundance of mouse dural afferent neurons that express neuropeptide calcitonin gene-related peptide as well as two TRP channels TRPV1 and TRPA1, respectively...
September 19, 2017: Headache
https://www.readbyqxmd.com/read/28922046/supraorbital-electrical-stimulation-in-management-of-chronic-type-tension-headache-a-randomized-controlled-study
#6
Nashwa S Hamed
BACKGROUND AND PURPOSE: Headache disorders are considered one of the ten most disabling conditions, for both males and females, according to the World Health Organization. Chronic type tension headache (CTTH) has a prevalence of 2-3% within the general population. The purpose of this research was to investigate the effect of stimulating noninvasively the trigeminal nerve in the supraorbital area (SOES) for treatment of CTTH. METHODS: In an 8-week period of intervention, 45 patients were divided equally into three groups...
September 18, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28920449/the-relationship-between-migraine-and-rosacea-systematic-review-and-meta-analysis
#7
Casper Emil Christensen, Frederikke Schelde Andersen, Nita Wienholtz, Alexander Egeberg, Jacob P Thyssen, Messoud Ashina
Objective To systematically review the association between migraine and rosacea. Background Migraine is a complex disorder with episodes of headache, nausea, photo- and phonophobia. Rosacea is an inflammatory skin condition with flushing, erythema, telangiectasia, papules, and pustules. Both are chronic disorders with exacerbations of symptoms almost exclusively in areas innervated by the trigeminal nerve. Previous studies found an association between these disorders. We review these findings, provide a meta-analysis, and discuss possible pathophysiological commonalities...
January 1, 2017: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/28920139/long-term-outcomes-of-microvascular-decompression-and-gamma-knife-surgery-for-trigeminal-neuralgia-a-retrospective-comparison-study
#8
EDITORIAL
Andras A Kemeny
No abstract text is available yet for this article.
September 18, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28920110/painful-neuropathy-caused-by-compression-of-the-inferior-alveolar-nerve-by-focal-osteosclerotic-lesion-of-the-mandible-a-case-report
#9
David Debevc, Tomaž Hitij, Andrej Kansky
Osteosclerotic lesions are a common finding on dental radiographs. They are considered developmental variants of a normal bone architecture and they usually do not need any treatment. The purpose of this article is to present a rare case of osteosclerotic lesion of the mandible causing trigeminal neuropathy by compression of the alveolar nerve. The pain started with dental hypersensitivity of the mandibular right first molar. Later on, signs of irreversible molar tooth pulpitis developed. Endodontic therapy and apicoectomy did not resolve the pain, which later intensified, and painful neuropathy localized to inferior alveolar nerve developed; therefore, surgical decompression was indicated...
2017: Quintessence International
https://www.readbyqxmd.com/read/28920040/parasympathetic-cholinergic-and-neuropeptide-mechanisms-of-migraine
#10
REVIEW
Nikita Mikhailov, Oleg V Mamontov, Alexei A Kamshilin, Rashid Giniatullin
CONTEXT: Migraine mechanisms remain largely uncovered for various reasons including a very high complexity of the neurophysiological mechanisms implicated in this disorder and a plethora of endogenous biologically active compounds involved in the pathological process. The functional role of parasympathetic innervation of meninges and cholinergic mechanisms of migraine are among little explored issues despite multiple evidence indirectly indicating the role of acetylcholine (ACh) and its analogues in migraine and other types of headache...
February 2017: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28919565/treatment-of-large-or-giant-cavernous-aneurysm-associated-with-a-persistent-trigeminal-artery-a-case-report-and-review-of-literature
#11
Tatsuya Ishikawa, Koji Yamaguchi, Hidenori Anami, Masatake Sumi, Tomomi Ishikawa, Takakazu Kawamata
BACKGROUND: Primitive trigeminal artery (PTA) is the most common anomaly of primitive carotid-basilar anastomosis and is associated with cerebrovascular anomalies, such as aneurysm. Large or giant cavernous aneurysm associated with PTA is rare, and the treatment strategies differ in comparison to large or giant aneurysm without PTA. In this article, we report an unusual case of a giant cavernous aneurysm associated with PTA and review treatment strategies for large or giant cavernous aneurysm associated with PTA...
September 14, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28919173/trigeminal-system-in-parkinson-s-disease-a-potential-avenue-to-detect-parkinson-specific-olfactory-dysfunction
#12
Cécilia Tremblay, Pascali Durand Martel, Johannes Frasnelli
BACKGROUND: Olfactory dysfunction (OD) is very frequent in Parkinson's disease (PD) and observed years before diagnosis. The trigeminal system, a chemosensory system allowing for the perception of spiciness, freshness, etc., is intimately connected to the olfactory system and although usually reduced in OD the trigeminal system is not well characterized in PD. We hypothesize that measuring trigeminal sensitivity potentially allows to discriminate between OD due to PD and OD due to other causes to potentially help the development of an early diagnostic tool...
September 11, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28918916/olfactory-deficits-decrease-the-time-resolution-for-trigeminal-lateralization
#13
A Oleszkiewicz, T Meusel, M Güpfert, B Westermann, T Hummel, A Welge-Lüssen
OBJECTIVES: To date the temporal resolution of the detection of almost simultaneously applied intranasal trigeminal stimuli is unknown. The aim of our study was to examine this temporal resolution in an/hyposmic subjects, who are known to have reduced trigeminal sensitivity and compare it with healthy controls. METHODS: Participants were 20 posttraumatic an/hyposmic patients, and 23 healthy controls (matched with regard to sex and age). Olfactory function was tested psychophysically using the Sniffin´ Sticks test battery...
September 15, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28918260/organization-of-sensory-feature-selectivity-in-the-whisker-system
#14
Michael R Bale, Miguel Maravall
Our sensory receptors are faced with an onslaught of different environmental inputs. Each sensory event or encounter with an object involves a distinct combination of physical energy sources impinging upon receptors. In the rodent whisker system, each primary afferent neuron located in the trigeminal ganglion innervates and responds to a single whisker and encodes a distinct set of physical stimulus properties - features - corresponding to changes in whisker angle and shape and the consequent forces acting on the whisker follicle...
September 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28914738/age-related-resting-state-functional-connectivity-in-the-olfactory-and-trigeminal-networks
#15
Prasanna Karunanayaka, Michael J Tobia, Qing X Yang
Brain networks for intranasal chemosensation have been shown to be intrinsically organized in humans . However, little is known about how changes in the intrinsic functional connectivity (FC) in chemosensory networks are related to aging. We, therefore, investigated the impact of age on resting-state FC in the olfactory and trigeminal networks (ON and TN) by combining two freely available resting-state fMRI data sets (obtained from the NITRC.org; Atlanta and New York) with data collected in our lab to generate a large sample size (N=103; 51 women) spanning the age range of 20-61 years...
October 18, 2017: Neuroreport
https://www.readbyqxmd.com/read/28911939/evaluation-of-airborne-sensory-irritants-for-setting-exposure-limits-or-guidelines-a-systematic-approach
#16
REVIEW
Gunnar Damgaard Nielsen, Peder Wolkoff
Sensory irritation of eyes and upper airways is an important endpoint for setting occupational exposure limits (OELs) and indoor air guidelines. Sensory irritants cause a painful burning, stinging and itching sensation. Controlled chamber studies are the "golden standard" for evaluations. Well conducted workplace studies offer another possibility. For generalization, the number of participants and their age, smoking, gender, and prior exposure, experience and mood has to be considered. Exposure assessments have to be reliable and exposure duration sufficiently long to establish time-response relationships...
September 11, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28911868/central-and-peripheral-expression-sites-of-phoenixin-14-immunoreactivity-in-rats
#17
Philip Prinz, Sophie Scharner, Tiemo Friedrich, Martha Schalla, Miriam Goebel-Stengel, Matthias Rose, Andreas Stengel
Phoenixin is a pleiotropic peptide involved in reproduction, anxiety and recently also implicated in the control of food intake. Besides the 20-amino acid phoenixin, the 14-amino acid phoenixin-14 also shows bioactive properties. However, the expression sites of phoenixin-14 in the brain and peripheral tissues are not yet described in detail. Therefore, a mapping of the brain and peripheral tissues from male and female Sprague-Dawley rats with a specific phoenixin-14 antibody was performed using western blot and immunohistochemistry...
September 11, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28910445/corneal-epithelium-derived-neurotrophic-factors-promote-nerve-regeneration
#18
Guohu Di, Xia Qi, Xiaowen Zhao, Songmei Zhang, Patrik Danielson, Qingjun Zhou
Purpose: To explore the neurotrophic factor expression in corneal epithelium and evaluate their effects on the trigeminal ganglion (TG) neurite outgrowth and corneal nerve regeneration in mice. Methods: The expression of neurotrophic factors was compared among the intact, regenerating, and regenerated mouse corneal epithelium. Mouse primary TG neurons were treated with the conditioned medium of mouse corneal epithelial cells. Nerve growth factor (NGF) neutralizing antibody and glial cell-derived neurotrophic factor (GDNF) neutralizing antibody were used to evaluate their roles in mouse corneal nerve regeneration and TG neurite outgrowth...
September 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28905370/neuromodulation-and-devices-in-trigeminal-neuralgia
#19
Kevin Weber
PREMISE: Trigeminal neuralgia is a severe facial pain disorder that has been studied for decades. Classical trigeminal neuralgia (CTN) is either idiopathic or caused by neurovascular compression. The related painful trigeminal neuropathies are often secondary to other causes, such as multiple sclerosis or trauma. PROBLEM: Therapies for trigeminal neuralgia and neuropathy have often been pharmacologic or surgical. Pharmacologic therapies are not effective in some cases and often cause side effects, some substantial...
September 14, 2017: Headache
https://www.readbyqxmd.com/read/28905114/long-term-outcomes-of-microvascular-decompression-and-gamma-knife-surgery-for-trigeminal-neuralgia-a-retrospective-comparison-study
#20
Takuro Inoue, Hisao Hirai, Ayako Shima, Fumio Suzuki, Masayuki Yamaji, Takanori Fukushima, Masayuki Matsuda
BACKGROUND: There is still no clear guideline for surgical treatment for patients with medically refractory trigeminal neuralgia (TN). When it comes to which surgical treatment to choose, microvascular decompression (MVD) or Gamma Knife surgery (GKS), we should know the long-term outcome of each treatment. METHODS: We analyzed 179 patients undergoing MVD and 52 patients undergoing GKS followed for 1 year or longer. We evaluated the patient's neurological status including pain relief, complications and recurrence...
September 14, 2017: Acta Neurochirurgica
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