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https://www.readbyqxmd.com/read/29470564/a-painful-submandibular-mass-in-a-patient-with-bruxism
#1
M Boyd Gillespie, Huaihong Chen, Tate Naylor
No abstract text is available yet for this article.
February 22, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29470127/telemedicine-physical-examination-utilizing-a-consumer-device-demonstrates-poor-concordance-with-in-person-physical-examination-in-emergency-department-patients-with-sore-throat-a-prospective-blinded-study
#2
Moneeb Akhtar, Paul G Van Heukelom, Azeemuddin Ahmed, Rachel D Tranter, Erinn White, Nathaniel Shekem, David Walz, Catherine Fairfield, J Priyanka Vakkalanka, Nicholas M Mohr
BACKGROUND: Telemedicine allows patients to connect with healthcare providers remotely. It has recently expanded to evaluate low-acuity illnesses such as pharyngitis by using patients' personal communication devices. The purpose of our study was to compare the telemedicine-facilitated physical examination with an in-person examination in emergency department (ED) patients with sore throat. MATERIALS AND METHODS: This was a prospective, observational, blinded diagnostic concordance study of patients being seen for sore throat in a 60,000-visit Midwestern academic ED...
February 22, 2018: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/29465614/radiation-induced-painful-neurogenic-hypertrophy-treated-with-botulinum-toxin-a
#3
Alexandra Filippakis, Doreen T Ho, Juan E Small, Kirstin M Small, Erik R Ensrud
Painful neurogenic hypertrophy is a rare complication of radiation therapy. We report a 27-year-old woman with a history of adenoid cystic carcinoma of the submandibular gland presented with painful twitching of her left shoulder. Electrodiagnostic studies were consistent with a diagnosis of radiation-induced spinal accessory nerve hyperactivity. The patient failed conventional medical therapy. She was treated with an injection of botulinum toxin A, and within 1 month experienced significant relief of symptoms...
March 2018: Journal of Clinical Neuromuscular Disease
https://www.readbyqxmd.com/read/29465352/immune-response-against-the-coiled-coil-domain-of-sj%C3%A3-gren-s-syndrome-associated-autoantigen-ro52-induces-salivary-gland-dysfunction
#4
Magdalena Sroka, Harini Bagavant, Indranil Biswas, Abigail Ballard, Umesh S Deshmukh
OBJECTIVES: The structural domains of Ro52, termed the RING, B-box, coiled coil (CC) and B30.2/SPRY are targets of anti-Ro52 in multiple autoimmune disorders. In Sjögren's syndrome patients, the presence of anti-Ro52 is associated with higher disease severity, and in mice, they induce salivary gland hypofunction. This study was undertaken to investigate whether immune responses against different domains of Ro52, influences salivary gland disease in mice. METHODS: Female NZM2758 mice were immunised with Ro52 domains expressed as recombinant fusion proteins with maltose binding protein (MBP) [MBP-RING-B-box, MBP-CC, MBP-CC(ΔC19), MBP-B30...
January 31, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29464006/delivery-of-sonic-hedgehog-gene-repressed-irradiation-induced-cellular-senescence-in-salivary-glands-by-promoting-dna-repair-and-reducing-oxidative-stress
#5
Bo Hai, Qingguo Zhao, Michael A Deveau, Fei Liu
Rationale: Irreversible hypofunction of salivary glands or xerostomia is common in head and neck cancer survivors treated with radiotherapy even when various new techniques are applied to minimize the irradiation (IR) damage. This condition severely impairs the quality of life of patients and can only be temporarily relieved with current treatments. We found recently that transient expression of Sonic Hedgehog (Shh) in salivary glands after IR rescued salivary function, but the underlying mechanisms are not totally clear...
2018: Theranostics
https://www.readbyqxmd.com/read/29462154/functional-characterization-and-genomic-studies-of-a-novel-murine-submandibular-gland-epithelial-cell-line
#6
Sangwon Min, Eun-Ah Christine Song, Akinsola Oyelakin, Christian Gluck, Kirsten Smalley, Rose-Anne Romano
A better understanding of the normal and diseased biology of salivary glands (SG) has been hampered, in part, due to difficulties in cultivating and maintaining salivary epithelial cells. Towards this end, we have generated a mouse salivary gland epithelial cell (mSGc) culture system that is well-suited for the molecular characterization of SG cells and their differentiation program. We demonstrate that mSGc can be maintained for multiple passages without a loss of proliferation potential, readily form 3D-spheroids and importantly express a panel of well-established salivary gland epithelial cell markers...
2018: PloS One
https://www.readbyqxmd.com/read/29460161/saliva-changes-in-parkinson-s-disease-patients-after-injection-of-botulinum-neurotoxin-type-a
#7
Janne Tiigimäe-Saar, Tiia Tamme, Marika Rosenthal, Liis Kadastik-Eerme, Pille Taba
Patients with Parkinson's disease (PD) are compromised by poor oral condition due to oropharyngeal bradykinesia, dysphagia, and the side effects of treatment. Intrasalivary gland injections of Botulinum neurotoxin type A (BNT-A) have been known to treat sialorrhea effectively in these patients. However, the decreased amount of saliva reduces self-cleaning ability that deteriorates oral hygiene and increases dental caries. The aim of this study was to determine the changes in the oral microflora and saliva in patients with PD treated for sialorrhea by means of sonography-controlled BNT-A injections into the bilateral parotid and submandibular glands...
February 19, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/29460025/combined-model-based-and-patient-specific-dosimetry-for-18-f-dcfpyl-a-psma-targeted-pet-agent
#8
Donika Plyku, Esther Mena, Steven P Rowe, Martin A Lodge, Zsolt Szabo, Steve Y Cho, Martin G Pomper, George Sgouros, Robert F Hobbs
PURPOSE: Prostate-specific membrane antigen (PSMA), a type-II integral membrane protein highly expressed in prostate cancer, has been extensively used as a target for imaging and therapy. Among the available PET radiotracers, the low molecular weight agents that bind to PSMA are proving particularly effective. We present the dosimetry results for18 F-DCFPyL in nine patients with metastatic prostate cancer. METHODS: Nine patients were imaged using sequential PET/CT scans at approximately 1, 12, 35 and 70 min, and a final PET/CT scan at approximately 120 min after intravenous administration of 321 ± 8 MBq (8...
February 19, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29456769/a-case-of-schwannoma-of-the-submandibular-region
#9
Babatunde O Bamgbose, Akiko Sato, Yoshinobu Yanagi, Miki Hisatomi, Yohei Takeshita, Irfan Sugianto, Junichi Asaumi
Background: We herein described a rare case of schwannoma of the hypoglossal nerve in the submandibular region with diagnostic imaging and histopathological findings. Case Report: A 31-years-old woman has had a palpable firm, rubbery, freely mobile mass in the submandibular region. Of imaging, MR images showed homogeneous isointensity on T1-weighted imaging (T1-WI), heterogeneous hypointensity on T2-WI, heterogeneous hyperintensity on short T1 inversion recovery (STIR), and heterogeneous enhancement on contrast-enhanced T1-WI...
2018: Open Dentistry Journal
https://www.readbyqxmd.com/read/29454757/open-reduction-and-internal-fixation-of-mandibular-condylar-base-and-neck-fractures-using-strut-plates
#10
Carolin Lechler, Florian Probst, Carl-Peter Cornelius, Wenko Smolka
PURPOSE: To evaluate clinical, radiologic, and functional outcomes of patients with condylar neck or base fractures treated with open reduction and internal fixation using strut plates. PATIENTS AND METHODS: Thirty patients with 34 condylar neck and base fractures were included in the study. Transoral endoscopically assisted, submandibular, or transparotid approaches were performed. Clinical and radiologic outcomes were evaluated. Functional outcomes were assessed with the Helkimo index in a subgroup of 15 patients...
February 2, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29454083/incidence-of-acute-suppurative-sialadenitis-in-end-stage-cancer-patients-a-retrospective-observational-study
#11
Hiroaki Watanabe, Takuya Odagiri, Yasuyuki Asai
CONTEXT: Acute suppurative sialadenitis (hereafter referred to as sialadenitis) is accompanied by pain and fever and can diminish the quality of life (QOL) in end-stage cancer patients; however, its incidence is not clear. OBJECTIVES: We conducted this study to elucidate the incidence of sialadenitis in end-stage cancer patients. METHODS: Retrospective review, observational study based on patients' medical records SUBJECTS: 726 consecutive cancer patients who died on the palliative care unit of our hospital between April 2012 and November 2016 were included...
February 14, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29449722/current-usefulness-of-aspiration-cytology-fnac-in-the-head-and-neck-diagnosis
#12
S Dallari, P M Gusella, P Campanella, M Ciommi, P Pantanetti, E Tortato, A Castriotta
Background: Fine Needle Aspiration Cytology (FNAC) is a well established and widely used method for both a preliminary and sometime final non-invasive pathologic diagnosis. FNAC is a simple and inexpensive diagnostic tool and should represent the standard of care in developing and resource-poor countries while maintaining its diagnostic usefulness in developed and advanced ones. Methods: The concordance between preoperative FNAC and final histology was evaluated in 168 patients operated on at the Otorhinolaryngology Unit, "A...
December 2017: Pathologica
https://www.readbyqxmd.com/read/29447642/is-it-just-a-psoriasiform-dermatitis
#13
Olalla Figueroa-Silva, Martina Espasandín-Arias, Francisco Javier García-Martínez, Virginia Fernández-Redondo, Jaime Toribio
Bazex syndrome (BS) is a rare paraneoplastic syndrome most frequently associated with squamous cell carcinomas of the upper aerodigestive tractand other tumours. Characteristically, cutaneous lesions precede the diagnosis of malignancy. We report a 72-year-old patient with 1-year history of acral dermatitis. The diagnosis of BS was based on the presence of psoriasiform acral dermatitis and the evidence of two simultaneous tumors (prostate adenocarcinoma and undifferentiated carcinoma ofthe submandibular gland)...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29440787/submandibular-fossa-augmentation-in-implant-dentistry
#14
Amin Rahpeyma, Saeedeh Khajehahmadi
Background: There are two limiting factors for determining the dental implant fixture length in mandibular posterior edentulous region: Inferior dental canal and submandibular fossa. Purpose: Submandibular fossa augmentation is a suggested way to overcome the problem of lingual undercut beneath the mylohyoid ridge in implant dentistry. Materials and Methods: Patients with lingual posterior bony undercut that interferes with the placement of a standard implant with a length of 10 mm were enrolled in this study...
May 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29435205/percutaneous-salivary-gland-ablation-using-ethanol-in-a-rat-model
#15
Emma Burch, Lacey Lubeley, James Murakami
Objectives: Sialorrhea is a common health and psychosocial problem for children with neuromuscular dysfunction secondary to a variety of disorders such as cerebral palsy. Current accepted treatments include the injection of botulinum toxin into the submandibular glands for temporary symptom relief. The purpose of this study is to demonstrate the feasibility of percutaneous ethanol injection for longer lasting salivary gland ablation in an animal model. Material and Methods: Twenty rats were used in this study...
October 2017: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/29434684/intraglandular-transplantation-of-adipose-derived-stem-cells-combined-with-platelet-rich-fibrin-extract-for-the-treatment-of-irradiation-induced-salivary-gland-damage
#16
Zhifa Wang, Hongyan Xing, Hanqing Hu, Taiqiang Dai, Yan Wang, Zhijin Li, Ran An, Haiyan Xu, Yanpu Liu, Bin Liu
The aim of the present study was to determine the effect of adipose-derived mesenchymal stem cells (ADSCs) combined with heterologous platelet-rich fibrin extract (PRFe) on irradiation-induced salivary gland (SG) damage. ADSCs were isolated from C3H mice, whereas PRFe was obtained from New Zealand rabbits. Twelve weeks post irradiation, the ADSCs or PRFe or their combination were transplanted into the submandibular glands of C3H mice with irradiation-induced damage. The salivary flow rate (SFR) was determined and histopathological analysis was performed at 12 weeks post transplantation...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434340/glucocorticoid-receptor-expression-in-resident-and-hematopoietic-cells-in-igg4-related-disease
#17
Taku Iguchi, Koji Takaori, Akiko Mii, Yuki Sato, Yasunori Suzuki, Hajime Yoshifuji, Hiroshi Seno, Osamu Ogawa, Koichi Omori, Kazuhisa Bessho, Satoru Kondo, Tomokazu Yoshizaki, Hitoshi Nakashima, Takao Saito, Tsuneyo Mimori, Hironori Haga, Mitsuhiro Kawano, Motoko Yanagita
Immunoglobulin G4-related disease is a rare immune-mediated disease characterized by the infiltration of IgG4-positive plasma cells and unique storiform fibrosis of multiple organs. The majority of IgG4-related disease patients respond to glucocorticoids, yet the precise mechanism of their action remains unclear. Pathological sections of the submaxillary gland, kidney, and retroperitoneum from 20 patients in total diagnosed with IgG4-related disease were analyzed for glucocorticoid receptor expression and the cell types expressing glucocorticoid receptor...
February 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29432741/dietary-nitrate-protects-submandibular-gland-from-hyposalivation-in-ovariectomized-rats-via-suppressing-cell-apoptosis
#18
Yipu Xu, Baoxing Pang, Liang Hu, Xiaoyu Feng, Lei Hu, Jingsong Wang, Chunmei Zhang, Songlin Wang
Xerostomia, a major oral symptom of menopause, is a subjective feeling of dry mouth associated with oral pain and difficulties in deglutition and speech, which significantly reduces patient's quality of life. Dietary nitrate, which can be converted to nitric oxide, has multiple physiological functions in the body, including antioxidant activity and vasodilatation; however, its protective effect against xerostomia remains poorly understood. The present study aimed to evaluate the effects of dietary nitrate on estrogen deficiency-induced xerostomia...
February 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29430238/a-case-of-advanced-submandibular-gland-cancer-in-which-increased-prostate-specific-antigen-and-multiple-bone-metastases-wrongly-suggested-concurrent-prostate-cancer
#19
Yoko Fukasawa, Takeshi Honda, Maika Natsume, Terunobu Haruyama, Masashi Ishihara, Takahiko Sakamoto, Ryo Usui, Shigeru Tanzawa, Shuji Ota, Yasuko Ichikawa, Kiyotaka Watanabe, Koji Saito, Nobuhiko Seki
A 73-year-old man, followed for prostatic hyperplasia, developed submandibular gland cancer. Initially, because of the concurrent presence of elevated serum prostate-specific antigen (PSA) and multiple bone metastases, he was clinically determined as having stage IV prostate cancer in addition to stage II submandibular gland cancer, and radical surgery for his submandibular gland cancer was performed first. However, subsequent detailed examinations of the prostate gland showed no prostate cancer, and a diagnosis of advanced submandibular gland cancer with increased PSA and multiple bone metastases was established...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29428494/survival-in-patients-with-submandibular-gland-carcinoma-results-of-a-multi-institutional-retrospective-study
#20
Koichiro Yamada, Keigo Honda, Hisanobu Tamaki, Shinzo Tanaka, Shogo Shinohara, Shinji Takebayashi, Ichiro Tateya, Morimasa Kitamura, Masanobu Mizuta, Toshiki Maetani, Tsuyoshi Kojima, Yoshiharu Kitani, Ryo Asato, Kazuyuki Ichimaru, Yohei Kumabe, Koji Ushiro, Koichi Omori
OBJECTIVE: Clinical studies demonstrating the prognostic factors in submandibular gland carcinoma are limited because the tumor is relatively rare. The aim of this study was to identify clinical outcomes and prognostic factors in submandibular gland carcinoma. METHODS: The study included 65 patients with submandibular gland carcinoma who underwent initial surgical treatment at the Kyoto University and its affiliated hospitals. RESULTS: The 3-year overall survival (OS), disease specific survival, locoregional control (LRC), and no distant metastasis (NDM) rates were 74...
February 7, 2018: Auris, Nasus, Larynx
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