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https://www.readbyqxmd.com/read/28647429/musculoskeletal-pain-and-voice-related-quality-of-life-in-dysphonic-and-non-dysphonic-subjects
#1
Ana Carolina Ramos, Rebeca Liaschi Floro, Vanessa Veis Ribeiro, Alcione Ghedini Brasolotto, Kelly Cristina Alves Silverio
PURPOSE: This study aimed to compare and correlate musculoskeletal pain and voice-related quality of life of dysphonic and non-dysphonic individuals. METHOD: This is a retrospective case-control study. A total of 74 adults were divided into two groups: the experimental group (EG) comprising 37 individuals with vocal complaints and hyperfunctional dysphonia, and the control group (CG) comprising 37 individuals without vocal complaints and with healthy voices. Both groups presented similar gender and age (28 females and 9 males for each group; average age = 31...
June 21, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28645176/efficacy-of-histatin5-in-a-murine-model-of-vulvovaginal-candidiasis-caused-by-candida-albicans
#2
Hong Liao, Shanling Liu, He Wang, Hang Su, Zhenjun Liu
Histatin5 (Hst-5) is a member of the histatin family of antimicrobial peptides secreted by human parotid and submandibular glands. With the natural antibacterial activity, it plays an important role in the first-line barrier of oral cave against pathogens, especially for the fungal intrusion. In this study, we explored the utility of Hst-5 in the treatment of vulvovaginal candidiasis, a common condition of women of the childbearing age. we used a synthesized Hst-5 over five consecutive days as the topical treatment in a murine model of vulvovaginal candidiasis...
June 22, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/28645101/co-localization-of-endogenous-arf6-and-its-activator-efa6d-in-the-granular-convoluted-tubule-cells-of-mouse-submandibular-glands-under-normal-conditions-and-when-stimulated-by-isoproterenol-noradrenaline-and-carbachol
#3
Apussara Tachow, Wipawee Thoungseabyoun, Laorrat Phuapittayalert, Kanoktip Petcharat, Hiroyuki Sakagami, Hisatake Kondo, Wiphawi Hipkaeo
OBJECTIVE: This study proposed to investigate the localization at light and electron microscopic levels of Arf6 and its activator EFA6D in the mouse submandibular gland (SMG) under normal conditions and when stimulated by adrenergic or cholinergic agonists. MATERIALS AND METHODS: SMGs of male adult mice were utilized for immunoblotting and immuno-light and -electron microscopic analyses. Isoproterenol and noradrenalin were used as adrenergics, while carbachol was used for the cholinergic stimulant...
June 13, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28640094/effects-of-first-radioiodine-ablation-on-functions-of-salivary-glands-in-patients-with-differentiated-thyroid-cancer
#4
Arun Upadhyaya, Zhaowei Meng, Peng Wang, Guizhi Zhang, Qiang Jia, Jian Tan, Xue Li, Tianpeng Hu, Na Liu, Pingping Zhou, Sen Wang, Xiaoxia Liu, Huiying Wang, Chunmei Zhang, Fengxiao Zhao, Ziyu Yan
The aim of this study was to evaluate the effects of the first radioactive iodine (I) therapy on functions of salivary glands in patients with differentiated thyroid carcinoma (DTC).There were 36 consented patients with DTC enrolled in this study, who received 3.7 GBq (100mCi) I for ablation after total thyroidectomy. Salivary gland function was assessed using salivary gland scintigraphy in two phases, one 4 hours before and the other 6 months after I therapy (both under thyrotropin stimulation condition)...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28639844/diagnostic-sensitivity-of-cutoff-values-of-igg4-positive-plasma-cell-number-and-igg4-positive-cd138-positive-cell-ratio-in-typical-multiple-lesions-of-patients-with-igg4-related-disease
#5
Ichiro Mizushima, Kazunori Yamada, Kenichi Harada, Shoko Matsui, Takako Saeki, Satoru Kondo, Masayuki Takahira, Yuko Waseda, Yasuhito Hamaguchi, Hiroshi Fujii, Masakazu Yamagishi, Mitsuhiro Kawano
OBJECTIVES: This study aimed to investigate the diagnostic sensitivity of the cutoff values of IgG4-positive plasma cell (PC) number and IgG4-positive/CD138-positive cell ratio proposed by the International consensus statement (ICS) on the pathology of IgG4-related disease (IgG4-RD) in typical multiple lesions of patients with IgG4-RD. METHODS: We evaluated IgG4-positive PC number and IgG4-positive/CD138-positive cell ratio in 39 samples from 18 IgG4-RD patients having more than two typical lesions of IgG4-RD...
June 22, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28637099/aggregation-and-phosphorylation-of-%C3%AE-synuclein-with-proteinase-k-resistance-in-focal-%C3%AE-synucleinopathy-predominantly-localized-to-the-cardiac-sympathetic-nervous-system
#6
Nei Fukasawa, Takahiro Fukuda, Masato Nagaoka, Tohru Harada, Hiroyuki Takahashi, Masahiro Ikegami
Aggregates of α-synuclein, a major component of Lewy bodies (LBs) and Lewy neurites (LNs), are distributed throughout the nervous system, including the central nervous system (CNS), sympathetic ganglia, enteric nervous system (ENS), cardiac and pelvic plexuses, submandibular gland, adrenal medulla and skin, in incidental Lewy body disease (ILBD), Parkinson's disease (PD), dementia with Lewy bodies (DLB), and pure autonomic failure (PAF) [1-3]. Here we report focal α-synucleinopathy predominantly localized to the cardiac sympathetic nervous system (SNS)...
June 21, 2017: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/28634562/a-simple-bone-cyst-in-cervical-vertebrae-of-an-adolescent-patient
#7
Adriana Bruges Boude, Lina González Vásquez, Fernando Alvarado-Gomez, María Constanza Bedoya, Andrés Rodríguez-Múnera, Luis Carlos Morales-Saenz
INTRODUCTION: Spinal simple bone cysts, also known as solitary cysts, are extremely unusual benign primary bone tumors with few cases reported in the literature. CASE PRESENTATION: Incidental Magnetic Resonance Imaging (MRI) finding of a C2 Simple bone cyst in a 13-year-old female patient is reported. Complementary studies suggested the benign nature of the lesion. Patient underwent cervical curettage followed by tumor excision. A lateral submandibular approach to the upper cervical spine was used and careful bone resection was possible with a radiofrequency assisted burr and no instrumentation or fixation was required...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/28630793/bilaterally-diffuse-lacrimal-gland-involvement-initial-presentation-of-systemic-sarcoidosis
#8
Pınar Bingöl Kızıltunç, Fatma Çiftçi, Banu Hoşal, Gülşah Kaygusuz
Orbital involvement in systemic sarcoidosis is a rare condition. We report a case of orbital sarcoidosis with bilaterally huge lacrimal gland involvement as the initial manifestation of systemic sarcoidosis. A 20-year-old woman admitted the ophthalmology department with progressive bilateral upper eyelid swelling for 6 months. The only pathologic finding was the presence of bilateral, symmetrical, solid, lobular masses at the lateral upper eyelids at the location of lacrimal glands. On systemic examination, bilateral parotid and submandibular glands appeared swollen...
June 2017: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28628162/-distant-metastases-of-malignant-salivary-gland-carcinoma-after-treated-by-125-i
#9
(no author information available yet)
OBJECTIVE: To investigate clinical features of distant metastases from malignant salivary gland carcinomas after treated by (125)I internal brachy therapy alone. METHODS: Between 2002 and 2010, 43 patients with locally advanced unresectable or recurrent malignant salivary gland carcinomas were treated by (125)I internal brachy therapy alone at Peking University School and Hospital of Stomatology. All of them had been follow-up at least 2 years. The primary sites of malignant salivary gland carcinomas were the parotid for 12 patients, infratemporal fossa for 9 patients, tongue for 7 patients, maxilla for 6 patients, parapharyngeal for 4 patients, floor of months for 3 patients, submandibular gland for 1 patient, and lip for 1 patient...
June 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/28623687/microcalcifications-in-stone-obstructed-human-submandibular-gland-are-associated-with-apoptosis-and-cell-proliferation
#10
Ivan Lau, Ajay Potluri, Cliff-Lawrence Ibeh, Robert S Redman, Edina Paal, Bidhan C Bandyopadhyay
OBJECTIVE: Human submandibular gland (SMG) stones are associated with inflammation, fibrosis and microcalcifications in the surrounding tissues. However, there is little information about the accompanying cell injury-repair process, apoptosis, and cell proliferation. The purpose of this study was to investigate such an association and its clinical significance. DESIGN OF STUDY: Mid-gland paraffin sections of human SMGs ("stone glands") and normal SMGs ("non-stone glands") were subjected to stains for general histology (hematoxylin and eosin), fibrosis (Masson's trichrome), and calcification (alizarin red) and to immunohistochemistry for proliferative activity (Ki-67), and apoptosis (Caspase-3)...
June 7, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28615711/identification-and-characterization-of-a-rich-population-of-cd34-mesenchymal-stem-stromal-cells-in-human-parotid-sublingual-and-submandibular-glands
#11
Padma Priya Togarrati, Robson T Sasaki, Mohamed Abdel-Mohsen, Nuntana Dinglasan, Xutao Deng, Shivani Desai, Elaine Emmerson, Elizabeth Yee, William R Ryan, Marcelo C P da Silva, Sarah M Knox, Satish K Pillai, Marcus O Muench
Mesenchymal stem/stromal cells (MSCs) play crucial roles in maintaining tissue homeostasis during physiological turnovers and injuries. Very little is known about the phenotype, distribution and molecular nature of MSCs in freshly isolated human salivary glands (SGs) as most reports have focused on the analysis of cultured MSCs. Our results demonstrate that the cell adhesion molecule CD34 was widely expressed by the MSCs of human major SGs, namely parotid (PAG), sublingual (SLG) and submandibular (SMG) glands...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28615430/characterization-of-patients-with-longstanding-idiopathic-rem-sleep-behavior-disorder
#12
Alex Iranzo, Ambra Stefani, Monica Serradell, Maria Jose Martí, Francisco Lomeña, Philipp Mahlknecht, Heike Stockner, Carles Gaig, Ana Fernández-Arcos, Werner Poewe, Eduard Tolosa, Birgit Högl, Joan Santamaria
OBJECTIVE: To evaluate the presence of prodromal markers of Parkinson disease (PD) in patients with longstanding idiopathic REM sleep behavior disorder (IRBD), a small subgroup of individuals with IRBD with long-term follow-up thought not to be at risk of developing PD. METHODS: Demographic, clinical, and neuroimaging markers of PD were evaluated in 20 patients with polysomnographic-confirmed long-standing IRBD and in 32 matched controls. RESULTS: Patients were 16 men and 4 women with mean age of 72...
June 14, 2017: Neurology
https://www.readbyqxmd.com/read/28614225/immunoglobulin-g4-related-disease-preceded-by-lung-involvement-a-case-report
#13
Miki Abo, Hazuki Takato, Satoshi Watanabe, Kazumasa Kase, Tamami Sakai, Hayato Koba, Johsuke Hara, Takashi Sone, Hideharu Kimura, Kazuo Kasahara
RATIONALE: Immunoglobulin G4-related disease (IgG4-RD) is a systemic condition involving various organs and vessels including the pancreas, bile duct, salivary glands, periorbital tissues, kidneys, lungs, lymph nodes, meninges, and aorta. Recently, some cases of IgG4-RD have been reported, in which only pulmonary lesions were present. It is not known whether IgG4-RD can be diagnosed on the basis of pulmonary lesions only, because increases in serum IgG4 levels and infiltration of IgG4-positive plasma cells into the lung tissue also occur in other inflammatory conditions...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28610838/bcl-2-expression-is-essential-for-development-and-normal-physiological-properties-of-tooth-hard-tissue-and-saliva-production
#14
Mohammad Ali Saghiri, Armen Asatourian, Zafer Gurel, Christine M Sorenson, Nader Sheibani
BACKGROUND: Apoptosis plays a fundamental role in appropriate tissue development and function. Although expression of Bcl-2 has been reported during tooth and submandibular gland (SMG) development, the physiological role Bcl-2 plays during these processes has not been addressed. This study was performed to evaluate the impact of Bcl-2 expression on the formation and properties of tooth hard tissue, and saliva production. METHODS: Twenty-four mice (12 males and 12 females) were divided into three groups of eight (n=8): group A (Bcl-2 +/+), group B (Bcl-2 +/-), and group C (Bcl-2 -/-) and subjected to micro-CT analyses...
June 10, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28608179/anterior-submandibular-retropharyngeal-odontoid-osteotomy-and-posterior-atlantoaxial-fusion-for-irreducible-atlantoaxial-dislocation-associated-with-odontoid-fracture-malunion
#15
Cheng Li, Jingzhu Duan, Lei Li
PURPOSE: To report a case of complex odontoid fracture malunion accompanied by atlantoaxial dislocation which was treated with a new surgical approach. METHODS: A 53-year-old female was admitted due to progressive symptoms with a stiff limp and unsteady gait. Preoperative examination, diagnostic radiography, computed tomography, and magnetic resonance imaging were performed following admission. The examinations showed odontoid fracture malunion, an old right axial zygapophyseal fracture, atlantoaxial dislocation, and spinal cord injury...
June 12, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28607892/manifestations-of-tuberculosis-in-otorhinolaryngology-practice-a-retrospective-study-conducted-in-a-coastal-city-of-south-india
#16
Rithika Sriram, Kiran M Bhojwani
Tuberculosis (TB) of the head and neck has proved to be a diagnostic challenge for otorhinolarynologists around the world and is often misdiagnosed as cancer. To contribute to a better understanding of TB in the head and neck region by assessing its various manifestations, presentations, diagnostic techniques, risk factors, coexisting illnesses and treatment modalities. This was a retrospective study conducted over a 3 year period (2012-2014) in 2 hospitals in South India, among patients diagnosed to have TB of the head and neck...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28600120/effects-of-cevimeline-on-excitability-of-parasympathetic-preganglionic-neurons-in-the-superior-salivatory-nucleus-of-rats
#17
Yoshihiro Mitoh, Hirotaka Ueda, Hiroyuki Ichikawa, Masako Fujita, Motoi Kobashi, Ryuji Matsuo
The superior salivatory nucleus (SSN) contains parasympathetic preganglionic neurons innervating the submandibular and sublingual salivary glands. Cevimeline, a muscarinic acetylcholine receptor (mAChR) agonist, is a sialogogue that possibly stimulates SSN neurons in addition to the salivary glands themselves because it can cross the blood-brain barrier (BBB). In the present study, we examined immunoreactivities for mAChR subtypes in SSN neurons retrogradely labeled with a fluorescent tracer in neonatal rats...
May 30, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28589113/chondroradionecrosis-of-the-larynx-in-a-patient-with-laryngeal-a-case-report
#18
Aslan Ahmadi, Mohammad Mahdi Salem, Mahdi Safdarian, Shahriar Ilkhani, Roghaieh Hamidian, Mostafa Cheraghipour, Ali Daneshvar, Farzad Izadi
INTRODUCTION: Actinomycosis of the larynx has been rarely reported in the literature and usually occurs in patients with a history of laryngeal carcinoma and radiation therapy. However, its co-existence with chondroradionecrosis due to radiotherapy is even rarer. The most common site of infection is the cervicofacial region, especially in the submandibular area. CASE REPORT: Here we report a 63-year-old male with a history of chemoradiotherapy because of laryngeal cancer 1 year earlier who presented with laryngeal actinomycosis...
May 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28588783/salivary-duct-carcinoma-treated-with-cetuximab-based-targeted-therapy-a-case-report
#19
Kenta Kawahara, Akimitsu Hiraki, Ryoji Yoshida, Hidetaka Arita, Yuichiro Matsuoka, Toshio Yamashita, Kan-Ichi Koga, Masashi Nagata, Akiyuki Hirosue, Daiki Fukuma, Hideki Nakayama
Salivary duct carcinoma is a highly aggressive disease with a poor prognosis. Surgical resection is currently the only curative treatment, as there is no effective systemic therapy for this malignancy. Recently, trastuzumab has been shown to exhibit therapeutic efficacy in the treatment of salivary duct carcinoma; similarly, molecularly targeted agents, such as cetuximab, are expected to be useful for salivary duct carcinoma treatment. We herein describe the case of a 56-year-old man diagnosed with salivary duct carcinoma in the left submandibular region, with ipsilateral multiple metastases to the neck lymph nodes...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28588500/temporal-expression-patterns-of-clock-genes-and-aquaporin-5-anoctamin-1-in-rat-submandibular-gland-cells
#20
Ryouichi Satou, Masaki Sato, Maki Kimura, Yoichi Ishizuka, Masakazu Tazaki, Naoki Sugihara, Yoshiyuki Shibukawa
Circadian rhythms are essential for health and regulate various physiological functions. These rhythms are regulated by a negative-feedback loop involving clock genes in the suprachiasmatic nucleus (SCN) and peripheral tissues. The rate of secretion of salivary substances, ions, and water follows a circadian rhythm, however, the relationship between the molecular mechanism of salivary secretion and peripheral circadian rhythm is not yet clear. Anoctamin 1 (ANO1, also known as TMEM16A) and Aquaporin 5 (AQP5) play an important role in the transport of ions and water in the submandibular glands (SGs)...
2017: Frontiers in Physiology
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