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https://www.readbyqxmd.com/read/28231367/fiddler-s-neck-a-review
#1
Calvin W Myint, Amy L Rutt, Robert T Sataloff
Fiddler's neck is a common dermatologic condition associated with instrument use in violin and viola players. It typically manifests as a submandibular and/or supraclavicular lesion. It is a benign condition, but it may be mistaken for lymphedema or a salivary gland malignancy. Otolaryngologists who treat patients with fiddler's neck should be aware of appropriate management protocols and the need to avoid surgical excision. We obtained informed consent from 3 violinists to present their cases as specific examples of fiddler's neck...
February 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28230590/modified-lateral-surgical-approach-to-the-pterygopalatine-fossa
#2
Masataka Uehara, Masaaki Sasaguri, Shunji Shiiba, Kazuhiro Tominaga
Oral cancer, especially that originates in the maxillary tuberosity, buccal mucosa, and maxillary alveolus, is apt to invade the pterygopalatine fossa, where an intraoral approach is nearly impossible. There are 2 main types of extraoral approach to the pterygopalatine fossa; the anterior approach and the lateral approach. Although the lateral approach has an advantage compared with the anterior approach in terms of cosmetics, after the operation numbness of the lower lip occurs due to the sacrifice of the mental nerve...
February 22, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28228909/igg4-related-disease-in-an-adolescent-with-radiologic-pathologic-correlation
#3
Renato Cesar Ferreira da Silva, Scott M Lieberman, Henry T Hoffman, Bruno Policeni, Amani Bashir, Richard J H Smith, T Shawn Sato
Immunoglobulin G4-related disease (IgG4RD) is an immune-mediated condition characterized by lymphoplasmacytic infiltrates and fibrosis of affected organs. IgG4RD may affect many different organs either individually or together in a multiorgan condition and, thus, incorporates a wide range of fibroinflammatory phenotypes with shared pathologic features. Although IgG4RD most commonly occurs in late adulthood, it may affect children and adolescents. Only one case of IgG4RD presenting as isolated submandibular gland involvement has been reported in the pediatric population...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28223859/histatin-peptides-pharmacological-functions-and-their-applications-in-dentistry
#4
REVIEW
Zohaib Khurshid, Shariq Najeeb, Maria Mali, Syed Faraz Moin, Syed Qasim Raza, Sana Zohaib, Farshid Sefat, Muhammad Sohail Zafar
There are many human oral antimicrobial peptides responsible for playing important roles including maintenance, repairing of oral tissues (hard or soft) and defense against oral microbes. In this review we have highlighted the biochemistry, physiology and proteomics of human oral histatin peptides, secreted from parotid and submandibular salivary glands in human. The significance of these peptides includes capability for ionic binding that can kill fungal Candida albicans. They have histidine rich amino acid sequences (7-12 family members; corresponding to residues 12-24, 13-24, 12-25, 13-25, 5-11, and 5-12, respectively) for Histatin-3...
January 2017: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/28222888/acinar-cell-response-to-liquid-diet-during-rats-growth-period-differs-in-submandibular-and-sublingual-glands-from-that-in-parotid-glands
#5
Shigeru Takahashi, Hiroki Uekita, Hiroto Taniwaki, Takanori Domon
Continuously feeding a liquid diet to growing rodents strongly inhibits parotid gland growth, due to suppressed growth of acinar cells. This study investigated whether a liquid diet had a similar effect on submandibular and sublingual glands of growing rats. Rats were weaned on day 21 after birth and then fed a pellet diet in the control group and a liquid diet in the experimental group for 0, 1, 2, 4, and 8 weeks. Their submandibular and sublingual glands were excised, weighed, and examined histologically, immunohistochemically (using antibodies to 5'-bromo-2-deoxyuridine and cleaved caspase 3), and ultrastructurally...
February 8, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28216207/musculoskeletal-pain-and-occupational-variables-in-teachers-with-voice-disorders-and-in-those-with-healthy-voices-a-pilot-study
#6
Jhonatan da Silva Vitor, Larissa Thaís Donalonso Siqueira, Vanessa Veis Ribeiro, Janine Santos Ramos, Alcione Ghedini Brasolotto, Kelly Cristina Alves Silverio
PURPOSE: This study aimed to compare musculoskeletal pain perception in teachers with voice disorders and in those with healthy voices, and to investigate the relationship between musculoskeletal pain and occupational variables (ie, work journey per week and working period). METHOD: Forty-three classroom teachers were divided into two groups: dysphonic group (DG), 32 classroom teachers with voice complaints and voice disorders; and non-DG, 11 classroom teachers without voice complaints and who are vocally healthy...
February 16, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28208029/l1-peptide-conjugated-fibrin-hydrogels-promote-salivary-gland-regeneration
#7
K Nam, C-S Wang, C L M Maruyama, P Lei, S T Andreadis, O J Baker
Hyposalivation contributes to dental caries, periodontitis, and microbial infections. Additionally, it impairs activities of daily living (e.g., speaking, chewing, and swallowing). Treatments for hyposalivation are currently limited to medications (e.g., the muscarinic receptor agonists pilocarpine and cevimeline) that induce saliva secretion from residual acinar cells and the use of saliva substitutes. However, given that these therapies provide only temporary relief, the development of alternative treatments to restore gland function is essential...
February 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28207533/lymphoepithelial-carcinoma-of-the-salivary-glands
#8
Yeun J Kim, Hyun S Hong, Sun H Jeong, Eun H Lee, Min J Jung
RATIONALE: Lymphoepithelial carcinoma (LEC) is a rare malignancy with the histopathological feature of undifferentiated carcinoma and an intermixed reactive lymphoplasmacytic infiltration. Although clinically significant because of its malignant nature, it is difficult to make a differential diagnosis by preoperative imaging. Here, we report 3 cases of primary LEC arising in the major salivary glands, which showed unusual imaging features unlike other malignant tumors. PATIENT CONCERNS: Our first case is a 44-year-old man with LEC in the right parotid gland, the second case is a 71-year-old woman with LEC in the right submandibular gland, and the third case is a 35-year-old woman with LEC in the right parotid gland...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28205307/segmentation-of-organs-at-risks-in-head-and-neck-ct-images-using-convolutional-neural-networks
#9
Bulat Ibragimov, Lei Xing
PURPOSE: Accurate segmentation of organs-at-risks (OARs) is the key step for efficient planning of radiation therapy for head and neck (HaN) cancer treatment. In the work, we proposed the first deep learning-based algorithm, for segmentation of OARs in HaN CT images, and compared its performance against state-of-the-art automated segmentation algorithms, commercial software, and interobserver variability. METHODS: Convolutional neural networks (CNNs)-a concept from the field of deep learning-were used to study consistent intensity patterns of OARs from training CT images and to segment the OAR in a previously unseen test CT image...
February 2017: Medical Physics
https://www.readbyqxmd.com/read/28194862/patterns-of-care-and-survival-of-adjuvant-radiation-for-major-salivary-adenoid-cystic-carcinoma
#10
Anna Lee, Babak Givi, Virginia W Osborn, David Schwartz, David Schreiber
OBJECTIVES/HYPOTHESIS: National Cancer Care Network guidelines suggest consideration of adjuvant radiation even for early stage adenoid cystic carcinoma of the salivary glands. We used the National Cancer Data Base (NCDB) to analyze practice patterns and outcomes of postoperative radiotherapy for adenoid cystic carcinomas. STUDY DESIGN: Retrospective NCDB review. METHODS: Patients with nonmetastatic adenoid cystic carcinoma of the parotid, submandibular, or another major salivary gland from 2004 to 2012 were identified...
February 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28191301/plunging-ranula-in-children-case-report-and-literature-review
#11
Veronica Carlini, Valeria Calcaterra, Noemi Pasqua, Marinella Guazzotti, Mario Fusillo, Gloria Pelizzo
Few cases of plunging ranulas (PRs) occur during childhood and the lesions are frequently misdiagnosed. Here, a PR in a child is reported along with a literature review. A seven-year-old female complaining of swelling in the midline neck, left-submandibular region, was evaluated. No oral cavity or major salivary glands abnormalities were detected. On palpation, a soft, painless, and fluid-containing mass was observed. The suspicion PR was performed by ultrasound. The diagnosis was confirmed with a histopathological examination...
November 17, 2016: Pediatric Reports
https://www.readbyqxmd.com/read/28184199/oxidative-modification-in-the-salivary-glands-of-high-fat-diet-induced-insulin-resistant-rats
#12
Urszula Kołodziej, Mateusz Maciejczyk, Agnieszka Miąsko, Jan Matczuk, Małgorzata Knaś, Piotr Żukowski, Małgorzata Żendzian-Piotrowska, Jan Borys, Anna Zalewska
Still little is known about the role of oxidative stress (OS) in the pathogenesis of the salivary gland dysfunction in the course of insulin resistance (IR). To induce IR rats was fed with a high fat diet (HFD) during 8 weeks. Stimulated and non-stimulated salivary flow rate, total protein, as well as oxidative damage markers: 4-HNE protein adduct, 8-isoprostanes (8-isoP), 8-hydroxy-D-guanosine (8-OHdG), advanced oxidation protein product (AOPP), and protein carbonyls (PC) were determined in the plasma and submandibular and parotid glands of IR and control rats...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28182103/filarial-abscess-aspiration-of-adult-gravid-female-worm-from-submandibular-region-an-unusual-presentation
#13
Ruquiya Afrose, Mohammad Feroz Alam, Syed Shamshad Ahmad, Mohammed Naim
Microfilaria is a major public health problem in tropical and subtropical countries and is an endemic problem in India. Wuchereria bancrofti is the most common filarial infection. In some cases, microfilariae and adult filarial worm have been incidentally detected in fine-needle aspirates of various lesions; detection of microfilaria from subcutaneous site or from abscess site is even rarer. We here report an unusual case of Bancroftian microfilariasis in a 68-year-old female coming from endemic area presenting with right submandibular abscess...
January 2017: Journal of Cytology
https://www.readbyqxmd.com/read/28177730/impaired-mitochondria-and-intracellular-calcium-transients-in-the-salivary-glands-of-obese-rats
#14
Jitjiroj Ittichaicharoen, Nattayaporn Apaijai, Pongpan Tanajak, Piangkwan Sa-Nguanmoo, Nipon Chattipakorn, Siriporn C Chattipakorn
PURPOSE: Long-term consumption of a high-fat diet (HFD) causes not only obese-insulin resistance, but is also associated with mitochondrial dysfunction in several organs. However, the effect of obese-insulin resistance on salivary glands has not been investigated. We hypothesized that obese-insulin resistance induced by HFD impaired salivary gland function by reducing salivation, increasing inflammation and fibrosis, as well as impairing mitochondrial function and calcium transient signaling...
December 21, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28163943/radiation-for-malt-of-the-submandibular-gland
#15
Juskaran Chadha, Marita S Teng, Julie Teruya-Feldstein, Richard L Bakst
We are reporting a case of a 27-year-old woman with a history of swelling in the left submandibular region. This swelling was associated with a mass, and this was pathologically confirmed to be an extranodal marginal zone lymphoma (MALT). The patient underwent surgical excision and postoperative adjuvant radiation therapy. The patient tolerated treatments well and remains free of disease. Here, we describe the case and management described in the current literature.
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/28161362/ngf-dependent-axon-growth-and-regeneration-are-altered-in-sympathetic-neurons-of-dystrophic-mdx-mice
#16
Loredana Lombardi, Irene Persiconi, Alessandra Gallo, Casper C Hoogenraad, Maria Egle De Stefano
Duchenne muscular dystrophy (DMD) is a lethal disease, determined by lack of dystrophin (Dp427), a muscular cytoskeletal protein also expressed by selected neuronal populations. Consequently, besides muscular wasting, both human patients and DMD animal models suffer several neural disorders. In previous studies on the superior cervical ganglion (SCG) of wild type and dystrophic mdx mice (Lombardi et al. 2008), we hypothesized that Dp427 could play some role in NGF-dependent axonal growth, both during development and adulthood...
February 2, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/28161190/a-spontaneous-high-grade-undifferentiated-mammary-carcinoma-in-a-seven-week-old-female-rat
#17
Ana I Faustino-Rocha, Adelina Gama, Paula A Oliveira, Antonieta Alvarado, Rita Ferreira, Mário Ginja
The present work describes a rare case of a spontaneous high-grade carcinoma in a seven-week-old Sprague-Dawley female rat that had been included in the control group of an assay of mammary carcinogenesis. The mass was detected at 50days of age, it grown quickly and the animal was humanely sacrificed eight days later. The tumor was located in the left cervical region, in the vicinity of the left submandibular and sublingual glands. It was soft and reddish and had several dens with a bloody content. The tumor was PAS negative and exhibited immunostaining for ER-α...
February 1, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28159752/studies-of-an-androgen-binding-protein-knockout-corroborate-a-role-for-salivary-abp-in-mouse-communication
#18
Amanda G Chung, Phillip M Belone, Barbora Vošlajerová Bímová, Robert M Karn, Christina M Laukaitis
The house mouse Androgen-binding protein (Abp) gene family is comprised of 64 paralogs, 30 Abpa and 34 Abpbg, encoding the alpha (ABPA) and betagamma (ABPBG) protein subunits that are disulfide-bridged to form dimers in secretions. Only 14 Abp genes are expressed in distinct patterns in the lacrimal (11) and submandibular glands (3). We created a knockout mouse line lacking two of the three genes expressed in submandibular glands, Abpa27 and Abpbg27, by replacing them with the neomycin resistance gene. The knockout genotype (-/-) showed no Abpa27 or Abpbg27 transcripts in submandibular gland cDNA libraries and there was a concomitant lack of protein expression of ABPA27 and ABPBG27 in the -/- genotype saliva, shown by elimination of these two proteins from the saliva proteome and the loss of cross-reactive material in the acinar cells of the submandibular glands...
February 3, 2017: Genetics
https://www.readbyqxmd.com/read/28154872/monitoring-the-biochemical-alterations-in-hypertension-affected-salivary-gland-tissues-using-fourier-transform-infrared-hyperspectral-imaging
#19
Shaiju S Nazeer, Rarinthorn Samrid, David Perez-Guaita, Parichat Prachaney, Kowit Chaisiwamongkol, Poungrat Pakdeechote, Ponlatham Chaiyarit, Bayden R Wood
Fourier transform infrared spectroscopy (FTIR) imaging has been applied to investigate biochemical differences between salivary glands from control and hypertensive rats. Male Sprague-Dawley rats were divided into two groups including a control group and another hypertension group that were treated orally, with N-nitro-l-arginine methyl ester (l-NAME) via drinking water for 3 weeks to develop hypertension. In the control group, rats were treated with only drinking water for 3 weeks. The formalin-fixed paraffin embedded tissue specimens from submandibular and sublingual glands were analysed with a FTIR focal plane array imaging spectrometer and multi-composite images of all tissue sections were analysed simultaneously using Unsupervised Hierarchical Cluster Analysis (UHCA) and the extracted spectra were further analysed using Partial Least Squares Discriminant Analysis (PLS-DA)...
February 3, 2017: Analyst
https://www.readbyqxmd.com/read/28150012/-a%C3%A2-submandibular-tumor
#20
C Breunig, S Lodes, Ph Benter, B Fleige, W Flügel, M Bloching
No abstract text is available yet for this article.
February 1, 2017: HNO
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