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https://www.readbyqxmd.com/read/29676804/the-biphasic-effect-of-extracellular-glucose-concentration-on-carbachol-induced-fluid-secretion-from-mouse-submandibular-glands
#1
Momomi Terachi, Chikara Hirono, Michinori Kitagawa, Makoto Sugita
Cholinergic agonists evoke elevations of the cytoplasmic free-calcium concentration ([Ca2+ ]i ) to stimulate fluid secretion in salivary glands. Salivary flow rates are significantly reduced in diabetic patients. However, it remains elusive how salivary secretion is impaired in diabetes. Here, we used an ex vivo submandibular gland perfusion technique to characterize the dependency of salivary flow rates on extracellular glucose concentration and activities of glucose transporters expressed in the glands. The cholinergic agonist carbachol (CCh) induced sustained fluid secretion, the rates of which were modulated by the extracellular glucose concentration in a biphasic manner...
April 20, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29675626/imaging-of-the-sublingual-and-submandibular-spaces
#2
REVIEW
Swapnil Patel, Alok A Bhatt
Divided by the mylohyoid muscle, the sublingual and submandibular spaces represent a relatively small part of the oral cavity, but account for a disproportionate amount of pathological processes. These entities are traditionally separated into congenital, infectious/inflammatory, vascular and neoplastic aetiologies. This article reviews the relevant anatomy, clinical highlights and distinguishing imaging features necessary for accurate characterisation. TEACHING POINTS: • The mylohyoid sling is a key anatomical landmark useful in surgical planning...
April 19, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29672325/primary-mammary-analog-secretory-carcinoma-masc-of-the-vulva-with-etv6-ntrk3-fusion-a-case-report
#3
Jane K Nguyen, Julia A Bridge, Chandrika Joshi, Jesse K McKenney
Mammary analog secretory carcinoma is a primary salivary gland neoplasm with histologic, immunophenotypic, and molecular features identical to those of secretory carcinoma of the breast. Similar neoplasms have now been reported to occur in various nonmammary sites including the parotid gland, submandibular gland, sinuses, lip, skin, thyroid gland, and lung. We report, to our knowledge, the first example of a primary vulvar neoplasm with pathologic features identical to secretory carcinoma of the breast and an ETV6-NTRK3 fusion...
April 19, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29670741/coexisting-sublingual-dermoid-cyst-and-heterotopic-gastrointestinal-cyst-case-report
#4
Göksel Şimşek-Kaya, İrem-Hicran Özbudak, Dinçer Kader
A heterotopic oral gastrointestinal cyst coexisting with a lingual dermoid cyst is a rare condition, with only 3 reported cases in the English-language literature. Clinically, both gastrointestinal and dermoid cysts tend to manifest as an asymptomatic swelling. Cysts above the mylohyoid often present with sublingual swelling, whereas those below the mylohyoid present with submental swelling. Increased salivation, altered speech, dyspnea and difficulties in eating, swallowing and respiration may be present, depending on the size of the cyst...
February 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29670723/plunging-ranula-in-a-78-year-old-male-a-rare-case-report
#5
Arunkumar Kamalakaran, Balaji Jayaraman, Saravanan Balasubramaniam, Rohini Thirunavukkarasu, Bharathi Ramakrishnan
The term Ranula is a Latin word meaning frog. It refers to a bluish translucent cystic lesion in the floor of the mouth resembling the underbelly of a frog. Ranulas can be true cysts occurring due to ductal obstruction of the sublingual gland or a minor salivary gland or a pseudocyst as a result of ductal injury leading to extravasation and accumulation of saliva in the surrounding tissues. Clinically ranulas present as intraoral or plunging ranulas. The prevalence of ranula is 0.2% per 1000 patients Ranulas account for 6% of all salivary gland cysts...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29670709/comparative-study-of-the-osteogenic-potential-of-mesenchymal-stem-cells-derived-from-different-sources
#6
Iman M Aboushady, Zeinab A Salem, Dina Sabry, Abbas Mohamed
Background: Mesenchymal stem cells (MSCs) can regenerate missing tissues and treat diseases. Hence, the current work aimed to compare the proliferation rate and the osteogenic differentiation potential of bone marrow MSCs (BMSCs), gingival MSCs (GMSCs) and submandibular MSCs (SMSCs). Material and Methods: MSCs derived from bone marrow, gingiva and submandibular salivary gland were isolated and cultured from rats. The proliferation capacity was judged by MTT proliferation Assay...
January 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29668308/ultrasound-elastography-in-diagnosis-and-follow-up-for-patients-with-sialolithiasis
#7
Christoph A Reichel, Teresa Vincek, Donata Gellrich, Florian Schrötzlmair, Dirk Clevert, Pamela Zengel
OBJECTIVE: This study aims to answer whether Acoustic Radiation Force Impulse Imaging (ARFI) can reasonably be employed in initial examination and follow-up during therapy in patients with sialolithiasis, one of the most common non-malignant disorders of the salivary glands. METHODS: Mechanical tissue properties of affected and contralateral healthy salivary glands were analyzed by ARFI in 129 patients with sialolithiasis. In different subgroup analyses, ARFI shear wave velocity values were compared between healthy and diseased submandibular or parotid glands, salivary glands with calculi exhibiting different sizes, as well as before and after therapy...
April 18, 2018: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/29656688/sensory-preservation-in-neck-dissection-outcomes-of-a-sub-sternocleidomastoid-approach
#8
Keigo Honda, Ryo Asato, Jun Tsuji, Masakazu Miyazaki, Shinpei Kada, Yukiko Kataoka, Akiko Taura, Mami Morita
OBJECTIVE: Cutaneous anesthesia in early postoperative period is common after neck dissection even if the cervical nerve (CN) rootlets are preserved. The aim of this study was to evaluate if the preservation of the terminal branches of CNs using sub-sternocleidomastoid (SCM) approach combined with medially placed skin incision can prevent early postoperative anesthesia. MATERIAL AND METHODS: A retrospective chart review was performed on 129 neck dissections in 87 head and neck cancer patients...
April 14, 2018: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/29656342/prosaposin-and-its-receptors-are-differentially-expressed-in-the-salivary-glands-of-male-and-female-rats
#9
Farzana Islam, Md Sakirul Islam Khan, Hiroaki Nabeka, Shouichiro Saito, Xuan Li, Tetsuya Shimokawa, Kimiko Yamamiya, Naoto Kobayashi, Seiji Matsuda
Salivary glands produce various neurotrophins that are thought to regulate salivary function during normal and pathological conditions. Prosaposin (PSAP) is a potent neurotrophin found in several tissues and various biological fluids and may play roles in the regulation of salivary function. However, little is known about PSAP in salivary glands. As the functions of salivary glands are diverse based on age and sex, this study examines whether PSAP and its receptors, G protein-coupled receptor 37 (GPR37) and GPR37L1, are expressed in the salivary glands of rats and whether sex and aging affect their expression...
April 14, 2018: Cell and Tissue Research
https://www.readbyqxmd.com/read/29651363/surgical-management-of-the-drooling-child
#10
REVIEW
Rachael Lawrence, Neil Bateman
Purpose of Review: Our goal is to present the most up-to-date options in the surgical management of drooling in the paediatric population. While the clinical assessment of the drooling child and conservative management options are discussed, this review focuses on the most recent evidence for surgical interventions to treat drooling in children. Recent Findings: In terms of advances in the management of drooling, further experience and outcomes with the use of botulinum toxin injections is discussed...
2018: Current Otorhinolaryngology Reports
https://www.readbyqxmd.com/read/29649431/diagnosis-and-management-of-children-with-mycobacterium-abscessus-infections-in-the-head-and-neck
#11
Justine Moe, Roy Rajan, Shelley Caltharp, Shelly Abramowicz
PURPOSE: Controversy exists regarding the most appropriate treatment strategy for children with nontuberculous mycobacterial (NTM) cervical lymphadenitis. Mycobacterium abscessus (MAB) is an uncommon cause of NTM cervical lymphadenitis. The purpose of the present study was to evaluate diagnosis, management, and treatment outcomes in children with MAB-associated cervical lymphadenitis resulting from a pulpotomy. MATERIALS AND METHODS: This was a retrospective chart review of children with NTM lymphadenitis of the head and neck caused by MAB treated at Children's Healthcare of Atlanta hospitals (Atlanta, GA)...
March 22, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29649019/nut-carcinoma-of-the-salivary-glands-clinicopathologic-and-molecular-analysis-of-3-cases-and-a-survey-of-nut-expression-in-salivary-gland-carcinomas
#12
Abbas Agaimy, Isabel Fonseca, Carmo Martins, Khin Thway, Ryan Barrette, Kevin J Harrington, Arndt Hartmann, Christopher A French, Cyril Fisher
NUT carcinoma (NC) represents a rare subset of highly aggressive poorly differentiated carcinomas characterized by rearrangement of the NUT (aka NUTM1, nuclear protein in testis) gene, most commonly fused to BRD4. Originally described as a mediastinal/thymic malignancy, NC has been reported at a variety of anatomic regions including the upper and lower aerodigestive tract. To date, only 7 NC cases of probable salivary gland origin have been reported. We herein describe 3 new cases (all affecting the parotid gland) in 2 women (39- and 55-y old) and 1 man (35-y old)...
April 11, 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29628996/regulatory-mechanisms-of-branching-morphogenesis-in-mouse-submandibular-gland-rudiments
#13
REVIEW
Masanori Kashimata, Toru Hayashi
Branching morphogenesis is an important developmental process for many organs, including the salivary glands. Whereas epithelial-mesenchymal interactions, which are cell-to-cell communications, are known to drive branching morphogenesis, the molecular mechanisms responsible for those inductive interactions are still largely unknown. Cell growth factors and integrins are known to be regulators of branching morphogenesis of salivary glands. In addition, functional microRNAs (miRNAs) have recently been reported to be present in the developing submandibular gland...
February 2018: Japanese Dental Science Review
https://www.readbyqxmd.com/read/29627151/warthin-s-tumour-in-oral-and-maxillofacial-regions-an-18-year-retrospective-study-of-1084-cases-in-an-eastern-chinese-population
#14
W Xu, H Lu, Y Zhu, M Ruan, C Zhang, W Yang, S Liu
There is little information in the English-language literature regarding Warthin's tumour (WT) in the eastern-Chinese population. A large retrospective study (1084 primary tumours over a period of 18years) was carried out to investigate the clinicopathological features (patients' gender, age and tumour location) of these tumours in this population. A total of 994 (91.7%) patients were male and 90 (8.3%) were female, with a male/female ratio of 11:1. The mean age was 56.48years (range 20-89years), with a peak incidence in the fifth to seventh decade (82...
April 4, 2018: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29624878/elastographic-ultrasound-an-additional-image-tool-in-sj%C3%A3-gren-s-syndrome
#15
Eric Kimura-Hayama, Sergio Criales-Vera, Luis Azpeitia-Espinosa, Carlos Pacheco-Molina, Edgardo Reyes, Guadalupe Lima, Diego Hernandez-Ramirez, Luis Llorente, Gabriela Hernandez-Molina
AIM: To evaluate the stiffness of parotid and submandibular glands using elastography ultrasound and to correlate it with B-mode ultrasonographical, clinical and serological features, salivary profibrotic and inflammatory chemokines, and salivary gland fibrosis. METHODS: We performed B-mode and elastography ultrasound of major salivary glands of 26 patients with primary Sjögren's syndrome. We registered the shear wave velocity (SWV) and correlated it with the morphologic ultrasonographic changes assessed by the Hocevar scale...
April 6, 2018: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/29622116/imaging-of-submandibular-and-sublingual-salivary-glands
#16
REVIEW
Amit K Agarwal, Sangam G Kanekar
The submandibular and sublingual salivary glands are major salivary glands with a wide spectrum of pathologic conditions. The corresponding spaces along the floor of mouth have complex anatomy, best evaluated with cross-sectional imaging. The spectrum of diseases in these regions varies from simple infection to advanced malignancy, not just from the gland itself but also from the surrounding structures. The most common abnormalities in these spaces are inflammatory and infectious, and computed tomography is currently the most common imaging modality used...
May 2018: Neuroimaging Clinics of North America
https://www.readbyqxmd.com/read/29620185/procaine-stimulates-aquaporin%C3%A2-5-expression-in-human-salivary-gland-ductal-cells-via-the-suppression-of-dna-methyltransferase%C3%A2-1
#17
Fan Wu, Jintao Wang, Jianming Sun, Liman Shen, Meijuan Liu, Erjun Zhao
The present study aimed to investigate whether procaine may upregulate the expression of aquaporin‑5 (AQP5) in human salivary gland ductal cells and the underlying mechanisms of this upregulation. Immortalized normal human salivary gland ductal cells (NS‑SV‑DC), lacking AQP5 protein expression, were used to measure the glandular secretion rate following treatment with procaine, and the protein expression levels of AQP5 in NS‑SV‑DC cells were measured by western blotting. In order to investigate the mechanism of procaine action on AQP5 protein expression, the protein expression and activity of DNA methyltransferase (DNMT)1, and the CpG methylation of AQP5, were investigated further...
March 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29617700/vasoactive-intestinal-peptide-protects-salivary-glands-against-structural-injury-and-secretory-dysfunction-via-il-17a-and-aqp5-regulation-in-a-model-of-sj%C3%A3-gren-syndrome
#18
Chengyin Li, Fenglin Zhu, Bin Wu, Yue Wang
OBJECTIVE: Sjögren syndrome (SS) is an autoimmune disease involving exocrine glands. Currently, drugs that can improve both abnormal immunity and exocrine gland function are needed. The study aimed to investigate the effect and mechanism of vasoactive intestinal peptide (VIP) on the immune response and exocrine gland function in SS. METHODS: We investigated the effects of VIP on the immune response and secretory function of submandibular glands using NOD mice, and analyzed the expression of IL-17A and AQP5 (aquaporin 5)...
April 4, 2018: Neuroimmunomodulation
https://www.readbyqxmd.com/read/29614832/ixeris-dentata-extract-increases-salivary-secretion-through-the-regulation-of-endoplasmic-reticulum-stress-in-a-diabetes-induced-xerostomia-rat-model
#19
Kashi Raj Bhattarai, Hwa-Young Lee, Seung-Hyun Kim, Hyung-Ryong Kim, Han-Jung Chae
This study aimed to investigate the molecular mechanism of diabetes mellitus (DM)-induced dry mouth and an application of natural products from Ixeris dentata (IXD), a recently suggested regulator of amylase secretion in salivary cells. Vehicle-treated or diabetic rats were orally treated with either water or an IXD extract for 10 days to observe the effect on salivary flow. We found that the IXD extract increased aquaporin 5 (AQP5) and alpha-amylase protein expression in the submandibular gland along with salivary flow rate...
April 2, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29606544/management-of-duct-obstruction-in-transplanted-submandibular-glands
#20
Jia-Zeng Su, Zhi-Gang Cai, Xiao-Jing Liu, Lan Lv, Guang-Yan Yu
BACKGROUND: Submandibular gland (SMG) transplantation is a successful treatment approach for patients with severe dry eye. However, duct obstruction can occur post-transplant. METHODS: We studied nineteen patients with duct obstruction of transplanted SMGs, including five interventional modalities: stone removal; secretory stimulation (to mimic "internal irrigation" with substantial secretory flow); irrigation; surgical opening of stenosis and orifice reconstruction; cephalic vein bypass and Wharton's duct reconstruction...
March 14, 2018: Journal of Cranio-maxillo-facial Surgery
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