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https://www.readbyqxmd.com/read/29656537/histological-evaluation-of-the-repair-process-of-replanted-rat-teeth-after-storage-in-resveratrol-dissolved-in-dimethyl-sulfoxide
#1
Wilson Roberto Poi, Celso Koogi Sonoda, Marina Fuzette Amaral, Alfredo Franco Queiroz, Alline Batistussi França, Daniela Atili Brandini
BACKGROUND/AIM: The storage media is directly related to the prognosis of avulsed teeth, with resveratrol drawing attention due to its antioxidant and anti-inflammatory proprieties. The aim of this study was to evaluate the repair process in rat teeth following delayed replantation after storage in resveratrol (R) dissolved in dimethyl sulfoxide (DMSO). MATERIAL AND METHODS: The upper right central incisors of 36 rats were divided into 4 groups. In Group I, the teeth were extracted and immediately replanted...
April 14, 2018: Dental Traumatology: Official Publication of International Association for Dental Traumatology
https://www.readbyqxmd.com/read/29656307/alveolar-bone-protective-effect-of-hiziki-extracts-on-the-progression-of-periodontitis
#2
Don-Gil Lee, Yu-Kyong Shin, Jae-Hee Park, Sang-Yong Park, Eunson Hwang, Jung-Eun Yang, Hae Jo, Ki-Young Kim, Gafurjon T Mavlonov, Tae-Hoo Yi
The purpose of this study was to evaluate the effects of hiziki extract on alveolar bone loss, inflammation, and osteo-biomarker expression in hPDL cells (10, 50, 100 μg/ml final concentrations in culture medium) and on a ligature-induced periodontitis rat model (50, 100, 200 mg/kg with oral administration). Hiziki extract increased alkaline phosphatase activity and mineralized nodule formation in hPDL cell. In western blot analysis, hiziki extract resulted in increased expression of osteoblast markers, including transforming growth factor beta (TGF-β), SMAD anchor for receptor activation (SARA) and runt-related transcription factor 2 (RUNX2) in hDPL cells...
April 14, 2018: Marine Biotechnology
https://www.readbyqxmd.com/read/29655703/the-effects-of-wild-bitter-gourd-fruit-extracts-on-icam-1-expression-in-pulmonary-epithelial-cells-of-c57bl-6j-mice-and-microrna-221-222-knockout-mice-involvement-of-the-mir-221-222-pi3k-akt-nf-%C3%AE%C2%BAb-pathway
#3
Hsin-Ching Sung, Chen-Wei Liu, Chien-Yu Hsiao, Shu-Rung Lin, I-Shing Yu, Shu-Wha Lin, Ming-Hsien Chiang, Chan-Jung Liang, Chi-Ming Pu, Yu-Chen Chen, Ming-Shian Lin, Yuh-Lien Chen
BACKGROUND: The extracts from wild bitter gourd fruit (WBGE) were reported to possess numerous pharmacological activities. However, the anti-inflammatory effects of WBGE on human lung epithelial cells and the underlying mechanisms have not been determined. PURPOSE: To evaluate the molecular basis of the effects of WBGE on intercellular adhesion molecule-1 (ICAM-1) expression in alveolar epithelial (A549) cells, C57BL/6 wild-type (WT) mice and microRNA (miR)-221/-222 knockout (KO) mice with or without tumor necrosis factor (TNF-α; 3 ng/ml) treatment...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655569/activation-of-the-porcine-alveolar-macrophages-via-toll-like-receptor-4-nf-%C3%AE%C2%BAb-mediated-pathway-provides-a-mechanism-of-resistin-leading-to-inflammation
#4
Bi Li, Jing Fang, Zhicai Zuo, Sirui Yin, Tingting He, Mingxian Yang, Junliang Deng, Liuhong Shen, Xiaoping Ma, Shumin Yu, Ya Wang, Zhihua Ren, Hengmin Cui
Resistin, a previously discovered cysteine-rich adipokine known to regulate glucose metabolism, has been emerged as a mediator in inflammation and immunity. Its level was supposed to be related to the expression of indicators, such as interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) in inflammation. Toll-like receptor 4 (TLR4) was reported to be a receptor for resistin in cells, like leukocytes and peripheral blood mononuclear cells (PBMC). However, the pro-inflammatory role of resistin and its intracellular mechanisms in alveolar macrophages have not been thoroughly validated...
April 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29652806/excessive-extracellular-atp-desensitizes-p2y2-and-p2x4-atp-receptors-provoking-surfactant-impairment-ending-in-ventilation-induced-lung-injury
#5
REVIEW
Djo Hasan, Joshua Satalin, Philip van der Zee, Michaela Kollisch-Singule, Paul Blankman, Atsuko Shono, Peter Somhorst, Corstiaan den Uil, Han Meeder, Toru Kotani, Gary F Nieman
Stretching the alveolar epithelial type I (AT I) cells controls the intercellular signaling for the exocytosis of surfactant by the AT II cells through the extracellular release of adenosine triphosphate (ATP) (purinergic signaling). Extracellular ATP is cleared by extracellular ATPases, maintaining its homeostasis and enabling the lung to adapt the exocytosis of surfactant to the demand. Vigorous deformation of the AT I cells by high mechanical power ventilation causes a massive release of extracellular ATP beyond the clearance capacity of the extracellular ATPases...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652756/radiological-evaluation-of-the-dimensions-of-lower-molar-alveoli
#6
Claudio Agostinelli, Agnese Agostinelli, Marco Berardini, Paolo Trisi
PURPOSE: The aim of the present radiological study was to analyze the alveolar bone morphology of the lower molars in physiological conditions. The main goal is to describe the bone anatomy of a hypothetically postextractive site in lower molar area. MATERIALS AND METHODS: Computed tomography scans of 100 patients were examined. Axial, paraxial, and Panorex sections were analyzed using a dedicated software. Precise reference points were encoded to make the bone measurements clear and repeatable...
April 12, 2018: Implant Dentistry
https://www.readbyqxmd.com/read/29652608/immunomodulatory-role-of-stem-cell-from-human-exfoliated-deciduous-teeth-on-periodontal-regeneration
#7
Xianling Gao, Zongshan Shen, Meiliang Guan, Qiting Huang, Lingling Chen, Wei Qin, Xiaohu Ge, Haijia Chen, Yin Xiao, Zhengmei Lin
Periodontitis is initiated by the infection of periodontal bacteria and subsequent tissue inflammation due to immunoreaction, eventually leading to periodontal apparatus loss. Stem cells from human exfoliated deciduous teeth (SHEDs) have exhibited beneficial characteristics in dental tissue regeneration. However, the immunomodulatory functions of SHEDs have not been elucidated in the context of periodontitis treatment. In this study, we investigated the potential immunomodulatory effects of SHEDs on experimental periodontitis and demonstrated that multi-dose delivery of SHEDs led to periodontal tissue regeneration...
March 20, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29652537/subphenotyping-and-classification-of-cleft-lip-and-alveolus-in-adult-unoperated-patients-a-new-embryological-approach
#8
Christl Vermeij-Keers, Anna M Rozendaal, Antonius J M Luijsterburg, Benny S Latief, Costas Lekkas, Lea Kragt, Edwin M Ongkosuwito
OBJECTIVE: Previously, a new embryological classification was introduced subdividing oral clefts into fusion and/or differentiation defects. This subdivision was used to classify all subphenotypes of cleft lip with or without alveolus (CL±A). Subsequently, it was investigated whether further morphological grading of incomplete CLs is clinically relevant, and which alveolar part is deficient in fusion/differentiation defects. DESIGN: Observational cohort study. SETTING: Three hundred fifty adult unoperated Indonesian cleft patients presented themselves for operation...
January 1, 2018: Cleft Palate-craniofacial Journal
https://www.readbyqxmd.com/read/29652291/whole-lung-lavage-in-a-patient-with-pulmonary-alveolar-proteinosis
#9
Lindsay R Hunter Guevara, Shane M Gillespie, Alan M Klompas, Norman E Torres, David W Barbara
Pulmonary alveolar proteinosis (PAP) is a rare syndrome in which phospholipoproteinaceous matter accumulates in the alveoli leading to compromised gas exchange. Whole-lung lavage is considered the gold standard for severe autoimmune PAP and offers favorable long-term outcomes. In this case report, we describe the perioperative management and procedural specifics of a patient undergoing WLL for PAP in which an anesthesiologist serves as the proceduralist and a separate anesthesiologist provides anesthesia care for the patient...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29652241/bacterial-burden-in-critically-injured-ventilated-patients-does-not-correlate-with-progression-to-pneumonia
#10
Bradley M Dennis, Richard D Betzold, Daryl Patton, Herbert A Hopper, Judith Jenkins, Chris Fonnesbeck, Wonder Drake, Addison K May
BACKGROUND: Ventilator-associated pneumonia (VAP) is common in critically injured patients. The pathogenesis of VAP is not completely understood. We hypothesized that mechanically ventilated trauma patients who develop pneumonia have a progressive increase in pathogen burden over the course of ventilation until a threshold for symptomatic pneumonia is reached, leading to clinical suspicion of VAP. METHODS: Critically injured adults ventilated for more than two successive days were enrolled...
March 13, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29652170/pulmonary-transplantation-of-human-ipsc-derived-macrophages-ameliorates-pulmonary-alveolar-proteinosis
#11
Christine Happle, Nico Lachmann, Mania Ackermann, Anja Mirenska, Gudrun Göhring, Kathrin Thomay, Adele Mucci, Miriam Hetzel, Torsten Glomb, Takuji Suzuki, Claudia Chalk, Silke Glage, Oliver Dittrich-Breiholz, Bruce Trapnell, Thomas Moritz, Gesine Hansen
Rationale While the transplantation of induced pluripotent stem cell (iPSC)-derived cells harbors enormous potential for the treatment of pulmonary diseases, in vivo data demonstrating clear therapeutic benefits of human iPSC-derived cells in lung disease models is missing. Objective We here tested the therapeutic potential of iPSC-derived macrophages in a humanized disease model of hereditary pulmonary alveolar proteinosis (herPAP). herPAP is caused by a genetic defect of the GM-CSF-receptor, which leads to disturbed macrophage differentiation and protein/surfactant degradation in the lungs subsequently resulting in severe respiratory insufficiency...
April 13, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29652024/intra-alveolar-extraction-of-impacted-distoangular-mandibular-third-molars-a-novel-technique
#12
K Santhosh Kumar, A Emmanuel Dhiravia Sargunam, C Ravindran, Gvv Giri
Recent trends in maxillofacial surgery are to reduce the trauma to the adjacent soft tissue. The distoangular impaction presents a challenge to the maxillofacial surgeon and also results in more surgical morbidity. Here, we present a minimally invasive extraction technique for the distoangular mandibular third molar impaction.
March 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29651856/postoperative-fixation-after-repositioning-of-premaxilla-in-a-patient-with-bilateral-cleft-lip-and-palate-case-report
#13
M Koťová, M Dušková, E Leamerová, W Urbanová, K Schwarzmannová, K Novotná, A Sukop
This article presents orthodontic-surgical treatment in an eight-year-old patient with bilateral cleft lip and palate where premaxilla was surgically repositioned in the mixed dentition stage. By cranial and dorsal insertion of the premaxilla were created satisfactory occlusal relationship for ongoing eruption of permanent teeth, together with functional lip closure, improved pronunciation and a positive change in appearance of the centrofacial area. Reposition of premaxilla was associated with bilateral alveolar bone grafting of the cleft defect with cancellous bone from the iliac crest...
2018: Acta Chirurgiae Plasticae
https://www.readbyqxmd.com/read/29651173/in-vitro-anticancer-activity-of-staphyloxanthin-pigment-extracted-from-staphylococcus-gallinarum-kx912244-a-gut-microbe-of-bombyx-mori
#14
Delicia Avilla Barretto, Shyam Kumar Vootla
The present study reports the in vitro biological nature of the pigment produced by Staphylococcus gallinarum KX912244, isolated as the gut microflora bacterium of the insect Bombyx mori . The purified pigment was characterized as Staphyloxanthin based on bio-physical characterization techniques like Fourier transform infrared spectroscopy, high performance liquid chromatography, Proton nuclear magnetic resonance spectroscopy (1 H NMR), Liquid chromatography-Mass spectroscopy and Gas chromatography-Mass spectroscopy...
June 2018: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/29650962/vascular-endothelial-growth-factor-mediates-the-therapeutic-efficacy-of-mesenchymal-stem-cell-derived-extracellular-vesicles-against-neonatal-hyperoxic-lung-injury
#15
So Yoon Ahn, Won Soon Park, Young Eun Kim, Dong Kyung Sung, Se In Sung, Jee Yin Ahn, Yun Sil Chang
We previously reported the role of vascular endothelial growth factor (VEGF) secreted by mesenchymal stem cells (MSCs) in protecting against neonatal hyperoxic lung injuries. Recently, the paracrine protective effect of MSCs was reported to be primarily mediated by extracellular vesicle (EV) secretion. However, the therapeutic efficacy of MSC-derived EVs and the role of the VEGF contained within EVs in neonatal hyperoxic lung injury have not been elucidated. The aim of the study was to determine whether MSC-derived EVs attenuate neonatal hyperoxic lung injury and, if so, whether this protection is mediated via the transfer of VEGF...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29650822/-a-case-of-poorly-differentiated-carcinoma-of-unknown-primary-site-with-risk-of-choriocarcinoma-syndrome-effectively-treated-with-reduced-bleomycin-cisplatin-etoposide-combination-regimen-bep-regimen
#16
Motohiko Okano, Hiroyasu Oda, Mikiya Ishihara, Satoshi Tamaru, Kanako Saito, Yoshiki Yamashita, Toshiro Mizuno, Naoyuki Katayama
A 64-year-old man visited his physician complaining of bilateral gynecomastia and left shoulder pain. Chest X-ray showed multiple bilateral masses in the lung, and he was referred to our hospital. Radiographical findings, elevation of serum total hCG, and histological findings of the cervical lymph node revealed multiple pulmonary, nodal, and brain metastases of poorly differentiated carcinoma of an unknown primary site with choriocarcinoma components. He was administered a regimen of reduced bleomycin, cisplatin, etoposide combination(reduced BEP regimen)to reduce the risk of acute respiratory failure with intra-alveolar hemorrhage related to post-chemotherapy early tumor necrosis...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650461/towards-designing-a-synthetic-antituberculosis-vaccine-the-rv3587c-peptide-inhibits-mycobacterial-entry-to-host-cells
#17
Mary Lilian Carabali-Isajar, Marisol Ocampo, Deisy Carolina Rodriguez, Magnolia Vanegas, Hernando Curtidor, Manuel Alfonso Patarroyo, Manuel Elkin Patarroyo
Mycobacterium tuberculosis is considered one of the most successful pathogens in the history of mankind, having caused 1.7 million deaths in 2016. The amount of resistant and extensively resistant strains has increased; BCG has been the only vaccine to be produced in more than 100 years though it is still unable to prevent the disease's most disseminated form in adults; pulmonary tuberculosis. The search is thus still on-going for candidate antigens for an antituberculosis vaccine. This paper reports the use of a logical and rational methodology for finding such antigens, this time as peptides derived from the Rv3587c membrane protein...
April 4, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29650311/an-object-oriented-computational-model-to-study-cardiopulmonary-hemodynamic-interactions-in-humans
#18
Chuong Ngo, Stephan Dahlmanns, Thomas Vollmer, Berno Misgeld, Steffen Leonhardt
BACKGROUND AND OBJECTIVE: This work introduces an object-oriented computational model to study cardiopulmonary interactions in humans. METHODS: Modeling was performed in object-oriented programing language Matlab Simscape, where model components are connected with each other through physical connections. Constitutive and phenomenological equations of model elements are implemented based on their non-linear pressure-volume or pressure-flow relationship. The model includes more than 30 physiological compartments, which belong either to the cardiovascular or respiratory system...
June 2018: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/29649906/knockdown-of-lncrna-malat1-contributes-to-the-suppression-of-inflammatory-responses-by-up-regulating-mir-146a-in-lps-induced-acute-lung-injury
#19
Lingling Dai, Guojun Zhang, Zhe Cheng, Xi Wang, Liuqun Jia, Xiaogang Jing, Huan Wang, Rui Zhang, Meng Liu, Tianci Jiang, Yuanjian Yang, Meng Yang
BACKGROUND: Acute lung injury (ALI) is a type of severe pulmonary inflammatory disease with high rates of morbidity and mortality. Now, an increasing number of studies suggest that lncRNAs may act as key regulators of the inflammatory response and play a crucial role in the pathogenesis of many inflammatory diseases. Our study firstly explored the function and underlying mechanism of lncRNA metastasis-associated lung adenocarcinoma transcription 1 (MALAT1) in regulating the inflammatory response of lipopolysaccharide (LPS)-induced ALI in rats...
April 13, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29649372/autogenous-bone-graft-versus-bovine-bone-graft-in-association-with-platelet-rich-plasma-for-the-reconstruction-of-alveolar-clefts-a-pilot-study
#20
Bruno Torres Bezerra, John Nadson Andrade Pinho, Fabrício Eneas Diniz Figueiredo, José Renato Moraes Carvalho Barreto Brandão, Lucas Celestino Guerzet Ayres, Luiz Carlos Ferreira da Silva
OBJECTIVE: To compare the outcomes of 2 different bone graft materials: autogenous bone grafts from mandibular symphysis and bovine bone grafts associated with platelet-rich plasma (PRP). METHODS: Twenty individuals met the inclusion criteria and accepted to participate in the study. Group A patients underwent alveolar bone grafting using autologous bone and group B patients using a bovine bone graft associated with PRP. Cone beam computed tomography scans were taken and reconstructed 3-dimensionally for all patients preoperatively and 1 year postoperatively...
January 1, 2018: Cleft Palate-craniofacial Journal
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