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https://www.readbyqxmd.com/read/29235978/rigid-amphipathic-fusion-inhibitors-demonstrate-antiviral-activity-against-african-swine-fever-virus
#1
Astghik Hakobyan, Inmaculada Galindo, Almudena Nañez, Erik Arabyan, Zaven Karalyan, Alexey A Chistov, Philipp P Streshnev, Vladimir A Korshun, Covadonga Alonso, Hovakim Zakaryan
Rigid amphipathic fusion inhibitors (RAFIs) are a family of nucleoside derivatives that inhibit the infectivity of several enveloped viruses by interacting with virion envelope lipids and inhibiting fusion between viral and cellular membranes. Here we tested the antiviral activity of two RAFIs, 5-(Perylen-3-ylethynyl)-arabino-uridine (aUY11) and 5-(Perylen-3-ylethynyl)uracil-1-acetic acid (cm1UY11) against African swine fever virus (ASFV), for which no effective vaccine is available. Both compounds displayed a potent, dose-dependent inhibitory effect on ASFV infection in Vero cells...
December 13, 2017: Journal of General Virology
https://www.readbyqxmd.com/read/29235201/assessment-of-bone-dimensions-in-the-anterior-maxilla-a-cone-beam-computed-tomography-study
#2
Sandra AlTarawneh, Abeer AlHadidi, Ahmad As Hamdan, Murad Shaqman, Emad Habib
PURPOSE: To evaluate labial and palatal bone thickness at the maxillary anterior teeth as well as distance from cemento-enamel junction (CEJ) to bone crest using cone beam computed tomography (CBCT). MATERIALS AND METHODS: Measurements were obtained for maxillary anterior teeth of 120 subject CBCT volumes including thickness of labial and palatal plates of bone (coronal, middle, and apical thirds), and distance between CEJ and alveolar bone crest mid-labially, mesially, and distally...
December 13, 2017: Journal of Prosthodontics: Official Journal of the American College of Prosthodontists
https://www.readbyqxmd.com/read/29235158/single-staged-implant-placement-using-bone-ring-technique-with-and-without-membrane-placement-an-experimental-study-in-the-beagle-dog
#3
Maiko Haga-Tsujimura, Ken Nakahara, Eizaburo Kobayashi, Kensuke Igarashi, Benoit Schaller, Nikola Saulacic
AIM: To evaluate the impact of a collagen membrane on bone remodeling and osseointegration of implants placed simultaneously with a bone ring technique. MATERIAL AND METHODS: Standardized, vertical alveolar bone defects in the mandibles of six dogs were created. Tapered dental implants designed for two-stage subcrestal placement were inserted simultaneously with a bone ring technique. On one side of the mandible, the augmented sites were covered with a collagenous membrane...
December 12, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/29234749/sinus-lift-grafting-with-anorganic-bovine-bone-vs-50-autologous-bone-mixed-with-50-anorganic-bovine-bone-2-years-after-loading-results-from-a-randomised-controlled-trial
#4
Silvio Mario Meloni, Sascha Alekshander Jovanovic, Milena Pisano, Erta Xhanari, Giacomo De Riu, Antonio Tullio, Marco Tallarico
PURPOSE: To compare the outcome of implants inserted in maxillary sinuses augmented with anorganic bovine bone (ABB) grafts vs mixed 50% ABB and 50% autologous bone graft, using a lateral window approach. MATERIALS AND METHODS: This study was designed as a randomised controlled trial of parallel groups. Patients in need of an implant-supported prosthesis in a maxillary posterior area with a residual alveolar bone height no greater than 4 mm (range 0-4 mm) were recruited for lateral sinus grafting...
2017: European Journal of Oral Implantology
https://www.readbyqxmd.com/read/29234060/heat-killed-lactobacillus-casei-confers-broad-protection-against-influenza-a-virus-primary-infection-and-develops-heterosubtypic-immunity-against-future-secondary-infection
#5
Yu-Jin Jung, Young-Tae Lee, Vu Le Ngo, Young-Hee Cho, Eun-Ju Ko, Sung-Moon Hong, Ki-Hye Kim, Ji-Hun Jang, Joon-Suk Oh, Min-Kyung Park, Cheol-Hyun Kim, Jun Sun, Sang-Moo Kang
Lactic acid bacteria (LAB) are the common probiotics. Here, we investigated the antiviral protective effects of heat-killed LAB strain Lactobacillus casei DK128 (DK128) on influenza viruses. Intranasal treatment of mice with DK128 conferred protection against different subtypes of influenza viruses by lessening weight loss and lowering viral loads. Protection via heat-killed DK128 was correlated with an increase in alveolar macrophage cells in the lungs and airways, early induction of virus specific antibodies, reduced levels of pro-inflammatory cytokines and innate immune cells...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233858/enhancement-of-glycolysis-by-inhibition-of-oxygen-sensing-prolyl-hydroxylases-protects-alveolar-epithelial-cells-from-acute-lung-injury
#6
Kentaro Tojo, Nao Tamada, Yusuke Nagamine, Takuya Yazawa, Shuhei Ota, Takahisa Goto
Cellular bioenergetic failure caused by mitochondrial dysfunction is a key process of alveolar epithelial injury during acute respiratory distress syndrome (ARDS). Prolyl hydroxylases (PHDs) act as cellular oxygen sensors, and their inhibition activates hypoxia-inducible factor (HIF), resulting in enhanced cellular glycolytic activity, which could compensate for impaired mitochondrial function and protect alveolar epithelial cells from ARDS. Here, we evaluated the effects of pharmacological PHD inhibition with dimethyloxalylglycine (DMOG) on alveolar epithelial cell injury using in vitro and in vivo ARDS models...
December 12, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29233703/the-risk-of-osteonecrosis-on-alveolar-healing-after-tooth-extraction-and-systemic-administration-of-antiresorptive-drugs-in-rodents-a-systematic-review
#7
REVIEW
Victor Lousan do Nascimento Poubel, Carolina Amália Barcellos Silva, Luis André Mendonça Mezzomo, Graziela De Luca Canto, Elena Riet Correa Rivero
PURPOSE: There is much concern about the increasing number of patients with medication-related osteonecrosis of the jaw (MRONJ), and many studies have been published in an attempt to understand the pathophysiology of this condition. This study aimed to systematically review the literature on MRONJ arising in rodents under antiresorptive drug therapy after tooth extraction. METHODS: A search of electronic databases, including LILACS, PROQUEST, PubMed, SCOPUS, and the Web of Science...
November 20, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29233471/resolvin-d1-regulates-epithelial-ion-transport-and-inflammation-in-cystic-fibrosis-airways
#8
Fiona C Ringholz, Gerard Higgins, Aurélie Hatton, Ali Sassi, Ahmad Moukachar, Coral Fustero-Torre, Monika Hollenhorst, Isabelle Sermet-Gaudelus, Brian J Harvey, Paul McNally, Valerie Urbach
BACKGROUND: Cystic Fibrosis (CF) lung disease is characterised by dysregulated ion transport that promotes chronic bacterial infection and inflammation. The impact of the specialised pro-resolution mediator resolvin D1 (RvD1) on airway surface liquid (ASL) dynamics and innate defence had not yet been investigated in CF airways. METHODS: Ex vivo studies were performed on primary cultures of alveolar macrophages and bronchial epithelial cells from children with CF and in human bronchial epithelial cell lines; in vivo studies were performed in homozygous F508del-CFTR mice treated with vehicle control or RvD1 (1-100nM)...
December 7, 2017: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29232398/remote-ischemic-preconditioning-attenuates-cardiopulmonary-bypass-induced-lung-injury
#9
Xiaona Zhou, Runzhu Jiang, Yucai Dong, Lifeng Wang
The use of cardiopulmonary bypass (CPB) in cardiac surgeries is known to induce pathological changes in vital organs such as lungs. Remote ischemic preconditioning (RIPC) is a protective strategy that has shown to be able to reduce tissue damage related to ischemia-reperfusion injury (IRI). The current study seeks to evaluate the beneficial effects of limb RIPC on lung tissues and function in a rat CPB model. RIPC, which consisted of three cycles of 5-min ischemia and subsequently 5-min reperfusion, was induced in the hind limbs of the animals via a tourniquet...
2017: PloS One
https://www.readbyqxmd.com/read/29232204/the-zygoma-and-the-symphysis-new-extra-alveolar-sites-for-long-mini-implants
#10
Carlos Villegas, Niloufar Azami, Ravindra Nanda, Flavio A Uribe
No abstract text is available yet for this article.
October 2017: Journal of Clinical Orthodontics: JCO
https://www.readbyqxmd.com/read/29232038/novel-techniques-and-preliminary-results-of-ex-vivo-liver-resection-and-autotransplantation-for-end-stage%C3%A2-hepatic-alveolar-echinococcosis-a-study-of-31-cases
#11
Xianwei Yang, Yiwen Qiu, Bin Huang, Wentao Wang, Shu Shen, Xi Feng, Yonggang Wei, Jianyong Lei, Jichun Zhao, Bo Li, Tianfu Wen, Lunan Yan
Ex vivo liver resection combined with autotransplantation is a recently introduced approach to cure end-stage hepatic alveolar echinococcosis (HAE), which is considered unresectable by conventional radical resection due to echinococcal dissemination into the crucial intrahepatic conduits and adjacent structures. This manuscript aims discuss the manipulation details and propose reasonable indications for this promising technique. All patients successfully underwent liver autotransplantation with no intraoperative mortality...
December 12, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29231967/therapeutic-potential-of-porcine-bronchoalveolar-fluid-derived-mesenchymal-stromal-cells-in-a-pig-model-of-lps-induced-ali
#12
Mahesh Khatri, Levi Arthur Richardson
In this study, we isolated mesenchymal stromal (stem) cells (MSCs) from broncho-alveolar lavage fluid (BAL) of 2-6 week-old commercial pigs. BAL-MSCs displayed fibroblastic morphology and possessed self-renewal properties. Similar to bone-marrow MSCs, BAL-MSCs expressed mesenchymal markers and both cell types lacked the expression of hematopoetic markers. BAL-MSCs, when cultured in differentiation induction media, differentiated into adipocytes, osteocytes and chondrocytes. Next, we examined if BAL-MSCs have the ability to treat lipopolysaccharide (LPS)-induced acute lung injury (ALI) in a pig model...
December 12, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29231883/silver-nanoparticles-in-the-lung-toxic-effects-and-focal-accumulation-of-silver-in-remote-organs
#13
Martin Wiemann, Antje Vennemann, Franziska Blaske, Michael Sperling, Uwe Karst
The distribution of silver (Ag) into remote organs secondary to the application of Ag nanoparticles (Ag-NP) to the lung is still incompletely understood and was investigated in the rat with imaging methods. Dose-finding experiments were carried out with 50 nm- or 200 nm-sized polyvinyl pyrrolidine (PVP)-coated Ag-NP using alveolar macrophages in vitro and female rats, which received Ag-NP via intratracheal instillation. In the main study, we administered 37.5-300 µg per rat lung of the more toxic Ag50-PVP and assessed the broncho-alveolar lavage fluid (BALF) for inflammatory cells, total protein and fibronectin after three and 21 days...
December 12, 2017: Nanomaterials
https://www.readbyqxmd.com/read/29230219/functional-impairment-of-mononuclear-phagocyte-system-by-the-human-respiratory-syncytial-virus
#14
REVIEW
Karen Bohmwald, Janyra A Espinoza, Raúl A Pulgar, Evelyn L Jara, Alexis M Kalergis
The mononuclear phagocyte system (MPS) comprises of monocytes, macrophages (MΦ), and dendritic cells (DCs). MPS is part of the first line of immune defense against a wide range of pathogens, including viruses, such as the human respiratory syncytial virus (hRSV). The hRSV is an enveloped virus that belongs to the Pneumoviridae family, Orthopneumovirus genus. This virus is the main etiological agent causing severe acute lower respiratory tract infection, especially in infants, children and the elderly. Human RSV can cause bronchiolitis and pneumonia and it has also been implicated in the development of recurrent wheezing and asthma...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29229731/activation-of-porcine-alveolar-macrophages-by-actinobacillus-pleuropneumoniae-lipopolysaccharide-via-the-tlr4-nf-%C3%AE%C2%BAb-mediated-pathway
#15
Bi Li, Jing Fang, Zhicai Zuo, Sirui Yin, Tingting He, Mingxian Yang, Junliang Deng, Liuhong Shen, Xiaoping Ma, Shumin Yu, Ya Wang, Zhihua Ren
Actinobacillus pleuropneumoniae (A. pleuropneumoniae) is a causative agent of the porcine contagious pleuropneumonia. Overproduction of pro-inflammatory cytokines like IL-1β, IL-6, TNF-α and Resistin in lung is an important feature of A. pleuropneumoniae infection. These pro-inflammatory cytokines enhance inflammatory and immunological responses. However, the mechanism that leads to cytokines production remains unclear. As a major virulent factor of A. pleuropneumoniae, lipopolysaccharide (LPS) may act as a potent stimulator of TLR4, triggering a number of intracellular signaling pathways that lead to synthesis of pro-inflammatory cytokines...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29229365/repair-of-maxillary-cystic-bone-defects-with-mesenchymal-stem-cells-seeded-on-a-cross-linked-serum-scaffold
#16
Luis Miguel Redondo, Verónica García, Beatriz Peral, Alberto Verrier, José Becerra, Ana Sánchez, Javier García-Sancho
Tissue engineering combining cross-linked serum scaffolds with bone-derived mesenchymal stem cells has displayed excellent results for repair of maxillofacial bone defects in animal models, but it had not been tested in humans yet. We present here a pilot clinical trial using autologous bone-derived mesenchymal stem cells (H-MSV) grown in a serum cross-linked scaffold (BioMax) for treatment of maxillary cysts in 9 patients. Cells obtained from alveolar bone were seeded in the BioMax scaffold prepared from autologous serum, expanded under GMP conditions, and subjected to osteogenic differentiation for 3-4 weeks before application...
November 16, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29229273/mannose-functionalized-solid-lipid-nanoparticles-are-effective-in-targeting-alveolar-macrophages
#17
Ana Costa, Bruno Sarmento, Vítor Seabra
Mannose receptor is highly expressed on alveolar macrophages, being a potential target to promote the specific local drug delivery of anti-tuberculosis agents through the use of functionalized nanocarriers. In this work, isoniazid (Isn)-loaded solid lipid nanoparticles (SLN), reinforced with stearylamine (SA) were produced by double emulsion technique and further surface-functionalized with mannose in a straightforward chemical approach. Upon pre-formulation assessment, SLN close to 500 nm average size, positively charged and with association efficiency of ISN close to 50% were obtained...
December 8, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29229270/intratracheal-instillation-of-alveolar-type-ii-cells-enhances-recovery-from-acute-lung-injury-in-rats
#18
Raquel Guillamat-Prats, Ferranda Puig, Marta Camprubí-Rimblas, Raquel Herrero, Anna Serrano-Mollar, Maria Nieves Gómez, Jessica Tijero, Michael A Matthay, Lluís Blanch, Antonio Artigas
BACKGROUND: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are characterized by excess production of inflammatory factors. Alveolar type II (ATII) cells help repair damaged lung tissue, rapidly proliferating and differentiating into alveolar type I cells after epithelial cell injury. In ALI, the lack of viable ATII favors progression to more severe lung injury. ATII cells regulate the immune response by synthesizing surfactant and other anti-inflammatory proteins and lipids...
November 8, 2017: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/29229259/effects-of-positive-airway-pressure-and-mechanical-ventilation-of-the-lungs-during-cardiopulmonary-bypass-on-pulmonary-adverse-events-after-cardiac-surgery-a-systematic-review-and-meta-analysis
#19
Yi-Chia Wang, Chi-Hsiang Huang, Yu-Kang Tu
OBJECTIVE: To investigate whether different ventilation strategies during cardiopulmonary bypass (CPB) can improve outcomes in adult cardiac surgery patients. DESIGN: Systematic review of randomized controlled trials with meta-analyses. SETTING: Clinical trials for human studies up to July 2016 were obtained from electronic databases (Medline, Embase, PubMed, and the Cochrane Central Register of Controlled Trials) and reference lists of relevant randomized trials and review articles...
September 14, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29229098/pulmonary-veno-occlusive-disease-an-important-consideration-in-patients-with-pulmonary-hypertension
#20
REVIEW
Ryan Balko, Hawa Edriss, Kenneth Nugent, Victor Test
Pulmonary veno-occlusive disease is a rare subcategory of pulmonary arterial hypertension (WHO Group 1). The disease is poorly understood and difficult to diagnose; it has no definitive cure to date. These patients present with nonspecific symptoms, including dyspnea, exercise intolerance, and weakness. Chest x-rays sometimes differ from idiopathic pulmonary arterial hypertension and may demonstrate alveolar infiltrates and pleural effusions. High resolution computed tomography scans reveal ground glass opacities, interlobular septal thickening, and lymphadenopathy...
November 2017: Respiratory Medicine
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