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Zhongyang Lu, Yanchun Li, Colleen W Brinson, Keith L Kirkwood, Maria F Lopes-Virella, Yan Huang
BACKGROUND: We reported that high-fat diet (HFD)-induced metabolic syndrome (MetS) exacerbates lipopolysaccharide (LPS)-stimulated periodontitis and palmitate, the major saturated fatty acid in the HFD, amplified LPS-stimulated gene expression in vitro. Since CD36 is a major receptor for fatty acids, we investigated periodontal CD36 expression in mice with periodontitis and MetS, and the role of CD36 in inflammatory genes in macrophages stimulated by palmitate. METHODS: MetS and periodontitis were induced in mice by HFD and periodontal injection of LPS, respectively...
October 18, 2016: Oral Diseases
Amita Rani, Sujata Mohanty, Pankaj Sharma, Jitender Dabas
INTRODUCTION: Alveolar osteitis (AO) is a well-known complication following tooth extraction. Plethora of literature is available regarding its treatment modalities signifying that none of the treatment is as effective as any another treatment. LASER on the other hand, has been used to promote soft tissue healing. MATERIAL AND METHOD: In order to evaluate the effects of laser on healing of AO we undertook a randomized clinical trial. In the trial, sixty patients diagnosed with AO were randomly divided into three groups viz: alvogyl, diode laser and Er:Cr:YSGG laser (erbium chromium yttrium scandium gallium garnet)...
September 2016: Journal of Maxillofacial and Oral Surgery
Jia Shi, Jian-Bo Yu, Wei Liu, Dan Wang, Yuan Zhang, Li-Rong Gong, Shu-An Dong, Da-Quan Liu
Acute respiratory distress syndrome (ARDS) is one of the most devastating complications of sepsis lacking of effective therapy. Mitochondrial dynamics undergoing continuous fusion and fission play a crucial role in mitochondrial structure and function. Fis1, as a small protein located on the outer membrane of mitochondria, has been thought to be an important protein mediated mitochondrial fission. During ARDS, alveolar macrophages suffer from increased oxidative stress and apoptosis, and also accompanied by disrupted mitochondrial dynamics...
October 14, 2016: Experimental Cell Research
Shahbaz R Arain, Julie K Freed, Jutta Novalija, Paul S Pagel, Thomas J Ebert
OBJECTIVE: The mechanism of perioperative hypotension in patients taking an angiotensin-receptor blocker up to the time of surgery remains unclear. This study tested the hypothesis that short-term angiotensin-receptor blocker treatment attenuated the sympathetic and vascular responses to autonomic stimuli in volunteers undergoing anesthesia. DESIGN: Randomized, crossover, blinded, pilot design. SETTING: Zablocki Veterans Affairs Medical Center, Milwaukee, WI...
August 11, 2016: Journal of Cardiothoracic and Vascular Anesthesia
Alicia M Waters, Laura L Stafman, Evan F Garner, Smitha Mruthyunjayappa, Jerry E Stewart, Gregory K Friedman, Jennifer M Coleman, James M Markert, G Yancey Gillespie, Elizabeth A Beierle
Rhabdomyosarcoma (RMS), a tumor of skeletal muscle origin, is the most common sarcoma of childhood. Despite multidrug chemotherapy regimens, surgical intervention, and radiation treatment, outcomes remain poor, especially in advanced disease, and novel therapies are needed for the treatment of these aggressive malignancies. Genetically engineered oncolytic viruses, such as herpes simplex virus-1 (HSV), are currently being explored as treatments for pediatric tumors. M002, an oncolytic HSV, has both copies of the γ134...
October 2016: Translational Oncology
Yang Yang, Ben-Quan Wu, Yan-Hong Wang, Yun-Feng Shi, Jin-Mei Luo, Jun-Hui Ba, Hui Liu, Tian-Tuo Zhang
Macrophages play an important role in inflammatory responses; however, miRNA-mediated repolarization of macrophages is essential for fulfilling this function. To clarify a series of changes at the RNA level in alveolar macrophages under normal and inflammatory conditions, bronchial alveolar lavage liquid (BALF) was collected from healthy volunteers or patients with pneumonia. This approach, which differs from that used in previously, provides more accurate information about the states of macrophages in different lung microenvironments...
October 18, 2016: Immunopharmacology and Immunotoxicology
Frederick A Jakobiec, Anna M Stagner, Natalie Homer, Michael K Yoon
PURPOSE: To further define the histopathologic features of breast carcinoma conducive to orbital metastasis. METHODS: Ten new female patients with orbital or eyelid breast cancer metastases encountered between 2011 and 2016 had their medical records reviewed for determining their clinical characteristics. Microscopic glass slides from biopsies and immunohistochemical test results were also analyzed. Biomarkers studied included cytokeratin 7, nuclear estrogen and progesterone receptors, HER2, and E-cadherin...
October 5, 2016: Ophthalmic Plastic and Reconstructive Surgery
Claudia Dellavia, Michele Giammattei, Daniela Carmagnola, Federica Musto, Elena Canciani, Matteo Chiapasco
PURPOSE: The aim of this work was to compare histologically bone biopsies obtained during dental implant placement in atrophic jaws reconstructed with fresh-frozen bone (FFB) or autologous bone blocks. MATERIALS AND METHODS: Twenty partially or totally edentulous patients were treated either with iliac crest FFB grafts (14 patients; group A) or with iliac crest autografts (6 patients; group B). Seven to 9 months later, dental implants were placed in the reconstructed jaws and bone biopsies were harvested...
September 28, 2016: Implant Dentistry
Crystal N Marconett, Beiyun Zhou, Mitsuhiro Sunohara, Tiffany M Pouldar, HongJun Wang, Yixin Liu, Megan E Rieger, Evelyn Tran, Per Flodby, Kimberly D Siegmund, Edward D Crandall, Ite A Laird-Offringa, Zea Borok
Diseases involving the distal lung alveolar epithelium include chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and lung adenocarcinoma. Accurate labeling of specific cell types is critical for determining the contribution of each to pathogenesis of these diseases. The distal lung alveolar epithelium is comprised of two cell types, alveolar epithelial type 1 (AT1) and type 2 (AT2) cells. While cell type-specific markers, most prominently surfactant protein C (SFTPC), have allowed detailed lineage tracing studies of AT2 cell differentiation and their roles in disease, studies of AT1 cells have been hampered by lack of genes with expression unique to AT1 cells...
October 17, 2016: American Journal of Respiratory Cell and Molecular Biology
Erica Dos Santos Carvalho, Rogério Hadid Rosa, Flávia de Moura Pereira, Ana Lia Anbinder, Isabel Mello, Sandra Marcia Habitante, Denise Pontes Raldi
The search for effective protocols to reduce the incidence of root resorptions and allow periodontal ligament repair is still challenging, given the unpredictable outcome of late tooth replantation. The aim of this study was to assess the effects of both high-power diode laser irradiation (DL) and basic fibroblast growth factor (FGF) on the periodontal healing of replanted teeth after extended extra-oral dry time METHODS: Maxillary incisors of 50 male rats were extracted and assigned to three experimental and two control groups (n = 10)...
October 17, 2016: Dental Traumatology: Official Publication of International Association for Dental Traumatology
Takahiro Kaneko, Satoshi Nakamura, Shunsuke Hino, Norio Horie, Tetsuo Shimoyama
BACKGROUND: Sinus lift is a bone augmentation procedure that improves the alveolar crest height in an atrophic posterior maxilla. However, the regenerated bone volume can vary and generally has a tendency to decrease after sinus operation. This article describes nongrafted maxillary sinus lift using a bioresorbable unsintered hydroxyapatite combined with poly L-lactide (HA/PLLA) mesh plate device and dental implant placement in an atrophic posterior maxilla, after which continuous bone gain was observed around the implant apex during a postoperative follow-up period of 3 years...
December 2016: Int J Implant Dent
Fumihiro Nishimaki, Hiroshi Kurita, Shinya Tozawa, Yuji Teramoto, Rishiho Nishizawa, Shin-Ichi Yamada
BACKGROUND: The purpose of this retrospective study was to accumulate data regarding the quality of postoperative neurosensory function after inferior alveolar nerve (IAN) transposition for dental implant placement. METHODS: The study included seven consecutive patients who underwent IAN transposition surgery for the insertion of a dental implant into the atrophic posterior mandible. Of these, six patients (seven sides) were available for long-term assessment of postoperative IAN function...
December 2016: Int J Implant Dent
Yukimori Isoda, Eisaku Imamura, Daisuke Ueno, Tsubasa Akaike, Yoshiki Hamada
Iliac particulate cancellous bone and marrow (PCBM) is still the most predictable autogenous graft material for vertical ridge reconstruction because of its high cell content as well as osteoinductive and osteoconductive properties. However, postoperative meralgia paresthetica, gait disturbance, pain, and bleeding have been reported following conventional harvesting from the anterior iliac crest. We present a case of minimally invasive harvesting of iliac PCBM. A short incision was made, and the iliac crest was exposed after elevation of the periosteal membrane...
December 2016: Int J Implant Dent
Yasunori Hotta, Koji Ito, Shinichi Komatsu, Takashi Saito
A single-tooth implant restoration is generally performed for maxillary single-first-molar replacement. If the interdental space between the second premolar and the second molar is large enough, a double-implant placement can be performed to avoid creating mesiodistal cantilever and to distribute occlusal loading forces.If there is not adequate space for a double-implant placement to be performed mesiodistally along the crest of the alveolar ridge line, they should be placed along a diagonal line offset lingually to increase the space...
December 2015: Int J Implant Dent
Michael Stiller, Rainer Mengel, Sebastian Becher, Bernhard Brinkmann, Barbara Peleska, Esther Kluk
BACKGROUND: This retrospective study evaluated soft-tissue grafting as a surgical treatment option for peri-implantitis in case of unsuitable basic skeletal morphology of the alveolar bone and lack of keratinized mucosa. METHODS: Twenty-eight patients (21 females, 7 males, at a mean age 59.4 years) were included with a total of 54 implants. All implants showed peri-implantitis and attached keratinized buccal mucosa of ≤2 mm. A surgical procedure of soft-tissue grafting (STG) was made by inserting an inlay and inlay-onlay transplant...
December 2015: Int J Implant Dent
Kazuki Takaoka, Emi Segawa, Michiyo Yamamura, Yusuke Zushi, Masahiro Urade, Hiromitsu Kishimoto
Dental implants play an important role in postoperative rehabilitation after surgical treatment of oral cancer through the provision of prosthetic tooth replacement. Two major implant prosthesis designs are available: fixed implant-supported prostheses and implant-supported overdentures. We herein report a case of a 16-year-old female patient who underwent alveolar ridge resection for treatment of mandibular gingival carcinoma. Following surgery, oral rehabilitation was attempted using an implant-supported overdenture on a gold bar retainer splinting four implants...
December 2015: Int J Implant Dent
Elise G Zuiderveld, Henny J A Meijer, Arjan Vissink, Gerry M Raghoebar
Single immediate implant replacement is accompanied by excellent survival rates and a favorable esthetic outcome. The objective of this report was to describe a surgical approach for removal of a buccal or palatally located impacted secondary canine, combined with extraction of the failing primary canine, and immediate placement and provisionalization of an implant. A window technique was applied for surgical removal of the impacted canine. The alveolar crest was preserved. After extraction of the primary canine, the implant was inserted with primary stability...
December 2015: Int J Implant Dent
Masayuki Fukuda, Satoru Matsunaga, Kento Odaka, Yuuya Oomine, Masaaki Kasahara, Masahito Yamamoto, Shinichi Abe
BACKGROUND: The purpose of this study was to reveal the structural properties that need to be considered in dental implant treatment by investigating differences between dentulous and edentulous maxillae in the three-dimensional (3D) microstructure of the incisive canals (ICs) and their surrounding bone. METHODS: A total of 40 maxillary bones comprising 20 dentulous maxillae and 20 edentulous maxillae were imaged by micro-CT for 3D observation and measurement of the IC and alveolar bone in the anterior region of the IC...
December 2015: Int J Implant Dent
Neena Jain, Pooja Rawat Mathur, Shoyeb Khan, Arvind Khare, Veena Mathur, Surendra Sethi
BACKGROUND AND AIMS: Early extubation is a desirable goal after general anesthesia. Very few studies have compared the effect of bispectral index (BIS) monitoring versus standard end-tidal anesthetic gas (ETAG) concentration monitoring on tracheal extubation time for halothane-based anesthesia. The aim of this study was to compare the effect of BIS versus ETAG-guided anesthesia on time to tracheal extubation for halothane-based anesthesia in general surgical setting. METHODS: This was a randomized, controlled double-blind study...
September 2016: Anesthesia, Essays and Researches
Keelara Shivalingaiah Savitha, Radhika Dhanpal, J Shilpa
BACKGROUND: Multimodal analgesia (MMA) by synergy with volatile anesthetics minimizes their use thus decreasing operation theater pollution and greenhouse gas emission. AIMS: To estimate minimum alveolar concentration (MAC) requirement of isoflurane (ISO) for skin incision with use of MMA in the study group versus conventional regime in the control group for a constant bispectral index (BIS). To observe the side effects of analgesic drugs administered in the study...
September 2016: Anesthesia, Essays and Researches
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