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https://www.readbyqxmd.com/read/27916388/application-of-dual-protease-column-for-hdx-ms-analysis-of-monoclonal-antibodies
#1
Sasidhar N Nirudodhi, Justin B Sperry, Jason C Rouse, James A Carroll
A co-immobilized, dual protease column was developed and implemented to more efficiently digest IgG molecules for hydrogen/deuterium exchange mass spectrometry (HDX-MS). The low-pH proteolytic enzymes pepsin and type XIII protease from Aspergillus were packed into a single column to most effectively combine the complementary specificities. The method was optimized using an IgG2 monoclonal antibody as a substrate because they are known to be more difficult to efficiently digest. The general applicability of the method was then demonstrated using IgG1 and IgG4 mAbs...
December 1, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27915195/hydrogen-deuterium-exchange-a-unique-and-effective-method-for-ms-fragmentation-behavior-elucidation-of-ginkgolides-and-its-application-to-systematic-research-in-ginkgo-biloba
#2
Xingliang Niu, Jun Luo, Deran Xu, Hongyan Zou, Lingyi Kong
Ginkgolides, the main active constituents of Ginkgo biloba, possess significant selectively inhibition on platelet-activating factor and pancreatic lipase and attract wide attention in pharmacological research area. In our study, an effective hydrogen/deuterium (H/D) exchange method was developed by exchanging the α-Hs of lactone groups in ginkgolides with Ds, which was very useful for the elucidation of the fragmentation patterns of ginkgolides in Quadrupole Time-of-flight Mass Spectrometry (Q-TOF-MS), especially in accurately distinguishing the type and position of substituent in framework of ginkgolides...
November 26, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27910726/the-effect-of-deuterium-oxide-on-the-conformational-stability-and-aggregation-of-bovine-serum-albumin
#3
Mouhamad Reslan, Veysel Kayser
Protein aggregation is a significant problem affecting the integrity of proteins, and is a major hindrance to the development of biopharmaceutical products. Deuterium Oxide (D2O), widely used in protein characterization studies, has been shown to promote protein aggregation when used as a substitute for water in most buffered protein solutions; however, a few studies have reported minor improvements in melting point temperatures for some proteins. Our study aims to investigate the effect of D2O on protein stability, using bovine serum albumin (BSA) as a model...
December 2, 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/27910689/high-resolution-main-ion-charge-exchange-spectroscopy-in-the-diii-d-h-mode-pedestal
#4
B A Grierson, K H Burrell, C Chrystal, R J Groebner, S R Haskey, D H Kaplan
A new high spatial resolution main-ion (deuterium) charge-exchange spectroscopy system covering the tokamak boundary region has been installed on the DIII-D tokamak. Sixteen new edge main-ion charge-exchange recombination sightlines have been combined with nineteen impurity sightlines in a tangentially viewing geometry on the DIII-D midplane with an interleaving design that achieves 8 mm inter-channel radial resolution for detailed profiles of main-ion temperature, velocity, charge-exchange emission, and neutral beam emission...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910679/neutron-emission-spectroscopy-of-dt-plasmas-at-enhanced-energy-resolution-with-diamond-detectors
#5
L Giacomelli, M Nocente, M Rebai, D Rigamonti, A Milocco, M Tardocchi, Z J Chen, T F Du, T S Fan, Z M Hu, X Y Peng, A Hjalmarsson, G Gorini
This work presents measurements done at the Peking University Van de Graaff neutron source of the response of single crystal synthetic diamond (SD) detectors to quasi-monoenergetic neutrons of 14-20 MeV. The results show an energy resolution of 1% for incoming 20 MeV neutrons, which, together with 1% detection efficiency, opens up to new prospects for fast ion physics studies in high performance nuclear fusion devices such as SD neutron spectrometry of deuterium-tritium plasmas heated by neutral beam injection...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910664/two-photon-lif-on-the-hit-si3-experiment-absolute-density-and-temperature-measurements-of-deuterium-neutrals
#6
Drew Elliott, Derek Sutherland, Umair Siddiqui, Earl Scime, Chris Everson, Kyle Morgan, Aaron Hossack, Brian Nelson, Tom Jarboe
Two-photon laser-induced fluorescence measurements were performed on the helicity injected torus (HIT-SI3) device to determine the density and temperature of the background neutral deuterium population. Measurements were taken in 2 ms long pulsed plasmas after the inductive helicity injectors were turned off. Attempts to measure neutrals during the main phase of the plasma were unsuccessful, likely due to the density of neutrals being below the detection threshold of the diagnostic. An unexpectedly low density of atomic deuterium was measured in the afterglow; roughly 100 times lower than the theoretical prediction of 10(17) m(-3)...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910661/spider-beam-dump-as-diagnostic-of-the-particle-beam
#7
M Zaupa, M Dalla Palma, E Sartori, M Brombin, R Pasqualotto
The beam power produced by the negative ion source for the production of ion of deuterium extracted from RF plasma is mainly absorbed by the beam dump component which has been designed also for measuring the temperatures on the dumping panels for beam diagnostics. A finite element code has been developed to characterize, by thermo-hydraulic analysis, the sensitivity of the beam dump to the different beam parameters. The results prove the capability of diagnosing the beam divergence and the horizontal misalignment, while the entity of the halo fraction appears hardly detectable without considering the other foreseen diagnostics like tomography and beam emission spectroscopy...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910639/performance-of-the-prototype-labr3-spectrometer-developed-for-the-jet-gamma-ray-camera-upgrade
#8
D Rigamonti, A Muraro, M Nocente, V Perseo, G Boltruczyk, A Fernandes, J Figueiredo, L Giacomelli, G Gorini, M Gosk, V Kiptily, S Korolczuk, S Mianowski, A Murari, R C Pereira, E P Cippo, I Zychor, M Tardocchi
In this work, we describe the solution developed by the gamma ray camera upgrade enhancement project to improve the spectroscopic properties of the existing JET γ-ray camera. Aim of the project is to enable gamma-ray spectroscopy in JET deuterium-tritium plasmas. A dedicated pilot spectrometer based on a LaBr3 crystal coupled to a silicon photo-multiplier has been developed. A proper pole zero cancellation network able to shorten the output signal to a length of 120 ns has been implemented allowing for spectroscopy at MHz count rates...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910625/gamma-ray-spectroscopy-at-mhz-counting-rates-with-a-compact-labr3-detector-and-silicon-photomultipliers-for-fusion-plasma-applications
#9
M Nocente, D Rigamonti, V Perseo, M Tardocchi, G Boltruczyk, A Broslawski, A Cremona, G Croci, M Gosk, V Kiptily, S Korolczuk, M Mazzocco, A Muraro, E Strano, I Zychor, G Gorini
Gamma-ray spectroscopy measurements at MHz counting rates have been carried out, for the first time, with a compact spectrometer based on a LaBr3 scintillator and silicon photomultipliers. The instrument, which is also insensitive to magnetic fields, has been developed in view of the upgrade of the gamma-ray camera diagnostic for α particle measurements in deuterium-tritium plasmas of the Joint European Torus. Spectra were measured up to 2.9 MHz with a projected energy resolution of 3%-4% in the 3-5 MeV range, of interest for fast ion physics studies in fusion plasmas...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910612/jet-diagnostic-enhancements-in-preparation-for-dt-operations
#10
J Figueiredo, A Murari, C Perez Von Thun, D Marocco, M Tardocchi, F Belli, M García Muñoz, A Silva, S Soare, T Craciunescu, M Santala, P Blanchard, I Balboa, N Hawkes
In order to complete the exploitation of the JET ITER-like Wall and to take full benefit from deuterium-tritium experiments on JET, a set of diagnostic system refurbishments or upgrades is in progress. These diagnostic enhancements focus mainly on neutron, gamma, fast ions, instabilities, and operations support. These efforts intend to provide better spatial, temporal, and energy resolution while increasing measurement coverage. Also previously non-existing capabilities, such as Doppler reflectometry is now available for scientific exploitation...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910604/response-function-of-single-crystal-synthetic-diamond-detectors-to-1-4-mev-neutrons-for-spectroscopy-of-d-plasmas
#11
M Rebai, L Giacomelli, A Milocco, M Nocente, D Rigamonti, M Tardocchi, F Camera, C Cazzaniga, Z J Chen, T F Du, T S Fan, A Giaz, Z M Hu, T Marchi, X Y Peng, G Gorini
A Single-crystal Diamond (SD) detector prototype was installed at Joint European Torus (JET) in 2013 and the achieved results have shown its spectroscopic capability of measuring 2.5 MeV neutrons from deuterium plasmas. This paper presents measurements of the SD response function to monoenergetic neutrons, which is a key point for the development of a neutron spectrometer based on SDs and compares them with Monte Carlo simulations. The analysis procedure allows for a good reconstruction of the experimental results...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910573/polycapillary-lenses-for-soft-x-ray-transmission-in-iter-model-comparison-with-experiments-and-potential-application
#12
D Mazon, C Liegeard, A Jardin, R Barnsley, M Walsh, M O'Mullane, A Sirinelli, F Dorchies
Measuring Soft X-Ray (SXR) radiation [0.1 keV; 15 keV] in tokamaks is a standard way of extracting valuable information on the particle transport and magnetohydrodynamic activity. Generally, the analysis is performed with detectors positioned close to the plasma for a direct line of sight. A burning plasma, like the ITER deuterium-tritium phase, is too harsh an environment to permit the use of such detectors in close vicinity of the machine. We have thus investigated in this article the possibility of using polycapillary lenses in ITER to transport the SXR information several meters away from the plasma in the complex port-plug geometry...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910565/first-neutron-spectroscopy-measurements-with-a-pixelated-diamond-detector-at-jet
#13
A Muraro, L Giacomelli, M Nocente, M Rebai, D Rigamonti, F Belli, P Calvani, J Figueiredo, M Girolami, G Gorini, G Grosso, A Murari, S Popovichev, D M Trucchi, M Tardocchi
A prototype Single crystal Diamond Detector (SDD) was installed at the Joint European Torus (JET) in 2013 along an oblique line of sight and demonstrated the possibility to carry out neutron spectroscopy measurements with good energy resolution and detector stability in discharges heated by neutral beam injection and radio-frequency waves. Starting from these positive results, within the Vertical Neutron Spectrometer project of the Joint European Torus, we have developed a pixelated instrument consisting of a matrix of 12 independent SDDs, called the Diamond Vertical Neutron Spectrometer (DVNS), which boosts the detection efficiency of a single SDD by an order of magnitude...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910563/a-neutron-activation-spectrometer-and-neutronic-experimental-platform-for-the-national-ignition-facility-invited
#14
C B Yeamans, N Gharibyan
At the National Ignition Facility, the diagnostic instrument manipulator-based neutron activation spectrometer is used as a diagnostic of implosion performance for inertial confinement fusion experiments. Additionally, it serves as a platform for independent neutronic experiments and may be connected to fast recording systems for neutron effect tests on active electronics. As an implosion diagnostic, the neutron activation spectrometers are used to quantify fluence of primary DT neutrons, downscattered neutrons, and neutrons above the primary DT neutron energy created by reactions of upscattered D and T in flight...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910549/developments-of-scintillator-based-soft-x-ray-diagnostic-in-lhd-with-csi-tl-and-p47-scintillators
#15
T Bando, S Ohdachi, Y Suzuki
Multi-channel soft x-ray (SX) diagnostic has been used in the large helical device (LHD) to research magnetohydrodynamic equilibria and activities. However, in the coming deuterium plasma experiments of LHD, it will be difficult to use semiconductor systems near LHD. Therefore, a new type of SX diagnostic, a scintillator-based type diagnostic, has been investigated in order to avoid damage from the radiation. A fiber optic plate coated by P47 scintillator will be used to detect SX emission. Scintillation light will be transferred by pure silica core optical fibers and detected by photomultiplier tubes...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910544/absolute-calibration-of-neutron-detectors-on-the-c-2u-advanced-beam-driven-frc
#16
R M Magee, R Clary, S Korepanov, F Jauregui, I Allfrey, E Garate, T Valentine, A Smirnov
In the C-2U fusion energy experiment, high power neutral beam injection creates a large fast ion population that sustains a field-reversed configuration (FRC) plasma. The diagnosis of the fast ion pressure in these high-performance plasmas is therefore critical, and the measurement of the flux of neutrons from the deuterium-deuterium (D-D) fusion reaction is well suited to the task. Here we describe the absolute, in situ calibration of scintillation neutron detectors via two independent methods: firing deuterium beams into a high density gas target and calibration with a 2 × 10(7) n/s AmBe source...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910543/extending-helium-partial-pressure-measurement-technology-to-jet-dte2-and-iter
#17
C C Klepper, T M Biewer, U Kruezi, S Vartanian, D Douai, D L Hillis, C Marcus
The detection limit for helium (He) partial pressure monitoring via the Penning discharge optical emission diagnostic, mainly used for tokamak divertor effluent gas analysis, is shown here to be possible for He concentrations down to 0.1% in predominantly deuterium effluents. This result from a dedicated laboratory study means that the technique can now be extended to intrinsically (non-injected) He produced as fusion reaction ash in deuterium-tritium experiments. The paper also examines threshold ionization mass spectroscopy as a potential backup to the optical technique, but finds that further development is needed to attain with plasma pulse-relevant response times...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910515/proton-pinhole-imaging-on-the-national-ignition-facility
#18
A B Zylstra, H-S Park, J S Ross, F Fiuza, J A Frenje, D P Higginson, C Huntington, C K Li, R D Petrasso, B Pollock, B Remington, H G Rinderknecht, D Ryutov, F H Séguin, D Turnbull, S C Wilks
Pinhole imaging of large (mm scale) carbon-deuterium (CD) plasmas by proton self-emission has been used for the first time to study the microphysics of shock formation, which is of astrophysical relevance. The 3 MeV deuterium-deuterium (DD) fusion proton self-emission from these plasmas is imaged using a novel pinhole imaging system, with up to five different 1 mm diameter pinholes positioned 25 cm from target-chamber center. CR39 is used as the detector medium, positioned at 100 cm distance from the pinhole for a magnification of 4 ×...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910497/analysis-techniques-for-diagnosing-runaway-ion-distributions-in-the-reversed-field-pinch
#19
J Kim, J K Anderson, W Capecchi, P J Bonofiglo, S H Sears
An advanced neutral particle analyzer (ANPA) on the Madison Symmetric Torus measures deuterium ions of energy ranges 8-45 keV with an energy resolution of 2-4 keV and time resolution of 10 μs. Three different experimental configurations measure distinct portions of the naturally occurring fast ion distributions: fast ions moving parallel, anti-parallel, or perpendicular to the plasma current. On a radial-facing port, fast ions moving perpendicular to the current have the necessary pitch to be measured by the ANPA...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910487/combined-neutron-and-x-ray-imaging-at-the-national-ignition-facility-invited
#20
C R Danly, K Christensen, V E Fatherley, D N Fittinghoff, G P Grim, R Hibbard, N Izumi, D Jedlovec, F E Merrill, D W Schmidt, R A Simpson, K Skulina, P L Volegov, C H Wilde
X-ray and neutrons are commonly used to image inertial confinement fusion implosions, providing key diagnostic information on the fuel assembly of burning deuterium-tritium (DT) fuel. The x-ray and neutron data provided are complementary as the production of neutrons and x-rays occurs from different physical processes, but typically these two images are collected from different views with no opportunity for co-registration of the two images. Neutrons are produced where the DT fusion fuel is burning; X-rays are produced in regions corresponding to high temperatures...
November 2016: Review of Scientific Instruments
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