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https://www.readbyqxmd.com/read/29351128/fluid-removal-with-ultrasound-guided-protocol-improves-the-efficacy-and-safety-of-dehydration-in-post-resuscitated-critically-ill-patients-a-quasi-experimental-before-and-after-study
#1
Luhao Wang, Chunfang Qiu, Xiangdong Guan, Minying Chen, Juan Chen, Xiang Si, Zhicheng Du, Yanqiu Liu, Bin Ouyang
Fluid overload is associated with increased morbidity and mortality in critically ill patients. However, researches rarely study the precise start or end point of fluid removal and no protocol was developed to control the fluid removal process. We hypothesized that individualized fluid removal with ultrasound-guided protocol could improve the efficacy and safety of fluid removal in post-resuscitated critically ill patients. A quasi-experimental, before and after trial was conducted to identify the benefits of ultrasound-guided fluid removal...
January 18, 2018: Shock
https://www.readbyqxmd.com/read/29347765/laser-excited-motion-of-liquid-crystals-confined-in-a-microsized-volume-with-a-free-surface
#2
A V Zakharov, P V Maslennikov
The thermally excited vortical flow in a microsized liquid crystal (LC) volume with a free LC-air interface has been investigated theoretically based on the nonlinear extension of the Ericksen-Leslie theory, with accounting the entropy balance equation. Analysis of the numerical results show that due to interaction between the gradients of the director field ∇n[over ̂] and temperature field ∇T, caused by the focused heating, the thermally excited vortical fluid flow is maintained in the vicinity of the heat source...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347684/scalable-and-fast-heterogeneous-molecular-simulation-with-predictive-parallelization-schemes
#3
Horacio V Guzman, Christoph Junghans, Kurt Kremer, Torsten Stuehn
Multiscale and inhomogeneous molecular systems are challenging topics in the field of molecular simulation. In particular, modeling biological systems in the context of multiscale simulations and exploring material properties are driving a permanent development of new simulation methods and optimization algorithms. In computational terms, those methods require parallelization schemes that make a productive use of computational resources for each simulation and from its genesis. Here, we introduce the heterogeneous domain decomposition approach, which is a combination of an heterogeneity-sensitive spatial domain decomposition with an a priori rearrangement of subdomain walls...
November 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347504/ion-beam-plasma-interaction-effects-on-electrostatic-solitary-wave-propagation-in-ultradense-relativistic-quantum-plasmas
#4
I S Elkamash, I Kourakis, F Haas
Understanding the transport properties of charged particle beams is important not only from a fundamental point of view but also due to its relevance in a variety of applications. A theoretical model is established in this article, to model the interaction of a tenuous positively charged ion beam with an ultradense quantum electron-ion plasma, by employing a rigorous relativistic quantum-hydrodynamic (fluid plasma) electrostatic model proposed in McKerr et al. [M. McKerr, F. Haas, and I. Kourakis, Phys. Rev...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347117/molecular-dynamics-study-on-characteristics-of-energy-and-tangential-momentum-accommodation-coefficients
#5
Hiroki Yamaguchi, Yu Matsuda, Tomohide Niimi
Gas-surface interaction is studied by the molecular dynamics method to investigate qualitatively characteristics of accommodation coefficients. A large number of trajectories of gas molecules colliding to and scattering from a surface are statistically analyzed to calculate the energy (thermal) accommodation coefficient (EAC) and the tangential momentum accommodation coefficient (TMAC). Considering experimental measurements of the accommodation coefficients, the incident velocities are stochastically sampled to represent a bulk condition...
July 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346864/effects-of-particle-fluid-density-ratio-on-the-interactions-between-the-turbulent-channel-flow-and-finite-size-particles
#6
Zhaosheng Yu, Zhaowu Lin, Xueming Shao, Lian-Ping Wang
A parallel direct-forcing fictitious domain method is employed to perform fully resolved numerical simulations of turbulent channel flow laden with finite-size particles. The effects of the particle-fluid density ratio on the turbulence modulation in the channel flow are investigated at the friction Reynolds number of 180, the particle volume fraction of 0.84%, and the particle-fluid density ratio ranging from 1 to 104.2. The results show that the variation of the flow drag with the particle-fluid density ratio is not monotonic, with a larger flow drag for the density ratio of 10...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29345541/running-mechanics-and-metabolic-responses-with-water-bottles-and-bottle-belt-holders
#7
Heather K Vincent, Laura A Zdziarski, Kyle Fallgatter, Giorgio Negron, Cong Chen, Trevor Leavitt, MaryBeth Horodyski, Joseph G Wasser, Kevin R Vincent
PURPOSE: This study determined whether differential kinematics, kinetics, rates of energy use and cardiopulmonary responses occurred during running with water bottles and bottle belt holders compared to running only. METHODS: Trained runners (N=42; 27.2±6.4 yr) ran on an instrumented treadmill for four conditions in a randomized order: 1) control run (CON); 2) hand-held full water bottle (FULL, 16.9 fluid oz; 454 g); 3) hand-held half-full water bottle (HALF, 8...
January 18, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29344350/the-sensitivity-of-the-human-thirst-response-to-changes-in-plasma-osmolality-a-systematic-review
#8
REVIEW
Fintan Hughes, Monty Mythen, Hugh Montgomery
Background: Dehydration is highly prevalent and is associated with adverse cardiovascular and renal events. Clinical assessment of dehydration lacks sensitivity. Perhaps a patient's thirst can provide an accurate guide to fluid therapy. This systematic review examines the sensitivity of thirst in responding to changes in plasma osmolality in participants of any age with no condition directly effecting their sense of thirst. Methods: Medline and EMBASE were searched up to June 2017...
2018: Perioperative Medicine
https://www.readbyqxmd.com/read/29343798/structural-and-functional-insights-into-s-thiolation-of-human-serum-albumins
#9
Fumie Nakashima, Takahiro Shibata, Kohei Kamiya, Jun Yoshitake, Ryosuke Kikuchi, Tadashi Matsushita, Isao Ishii, Juan A Giménez-Bastida, Claus Schneider, Koji Uchida
Human serum albumin (HSA) is the most abundant serum protein, contributing to the maintenance of redox balance in the extracellular fluids. One single free cysteine residue at position 34 is believed to be a target of oxidation. However, the molecular details and functions of oxidized HSAs remain obscure. Here we analyzed serum samples from normal subjects and hyperlipidemia patients and observed an enhanced S-thiolation of HSA in the hyperlipidemia patients as compared to the control individuals. Both cysteine and homocysteine were identified as the low molecular weight thiols bound to the HSAs...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29342458/glucocorticoids-modulate-th1-and-th2-responses-in-asthmatic-mouse-models-by-inhibition-of-notch1-signaling
#10
Chengping Hu, Zhifang Li, Juntao Feng, Yongjun Tang, Ling Qin, Xinyue Hu, Yan Zhang, Ruoxi He
BACKGROUND: Notch1 has been linked to the pathogenesis of asthma due to its contribution on Th1/Th2 imbalance. γ-Secretase inhibitor (GSI) acts as an effective blocker of Notch1 signaling. Glucocorticoids (GCs) are the most effective anti-inflammatory drugs for asthma. The present study investigated the involvement of the Notch1 pathway in the anti-inflammatory effect of GCs and its association with Th1/Th2 balance. METHODS: The asthma model was established in BALB/c mice by sensitization with ovalbumin (OVA)...
January 18, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29340799/fully-automated-life-support-an-implementation-and-feasibility-pilot-study-in-healthy-pigs
#11
Wilfried Klingert, Jörg Peter, Christian Thiel, Karolin Thiel, Wolfgang Rosenstiel, Kathrin Klingert, Christian Grasshoff, Alfred Königsrainer, Martin Schenk
BACKGROUND: Automated systems are available in various application areas all over the world for the purpose of reducing workload and increasing safety. However, such support systems that would aid caregivers are still lacking in the medical sector. With respect to workload and safety, especially, the intensive care unit appears to be an important and challenging application field. Whereas many closed-loop subsystems for single applications already exist, no comprehensive system covering multiple therapeutic aspects and interactions is available yet...
January 16, 2018: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/29339230/balanced-crystalloids-vs-0-9-saline-for-adult-patients-undergoing-non-renal-surgery-a-meta-analysis
#12
REVIEW
Lili Huang, Xiaoshuang Zhou, Hai Yu
BACKGROUND: Fluid maintenance and resuscitation is an important strategy during major surgeries. There has been a debate on the choice of crystalloids over the past decades. 0.9% saline (normal saline) is more likely to cause hyperchloremic acidosis when compared to balanced crystalloids with low chloride content. Meta-analyses comparing these two kinds of crystalloids have been performed in renal transplantations. We aim to compare the safety of balanced crystalloids to normal saline among adult patients undergoing non-renal surgery...
January 12, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29332562/the-delicate-balance-between-the-good-and-the-bad-il-1-proinflammatory-effects-in-endometriosis
#13
Justyna Sikora, Simone Ferrero, Aleksandra Mielczarek-Palacz, Zdzislawa Kondera-Anasz
BACKGROUND: Endometriosis is an inflammatory gynaecological disease with an associated chronic inflammation. Interleukin(IL)-1 is one of the most important immune and proinflammatory factors, produced mainly by monocytes and macrophages. Studies indicate the role of the cytokine from IL-1 family in endometrium-related disorders, particularly in endometriosis. METHODS: The information about the impact of cytokine from IL-1 cytokine family on the pathogenesis and development of endometriosis was obtained with an electronic literature search based on the PubMed and Medline databases, spanning the period of January 1950 to July 2017 and includes associated references in the published studies...
January 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29332180/cd39-adenosinergic-axis-in-renal-pathophysiology-and-therapeutics
#14
REVIEW
Bellamkonda K Kishore, Simon C Robson, Karen M Dwyer
Extracellular ATP interacts with purinergic type 2 (P2) receptors and elicits many crucial biological functions. Extracellular ATP is sequentially hydrolyzed to ADP and AMP by the actions of defined nucleotidases, such as CD39, and AMP is converted to adenosine, largely by CD73, an ecto-5'-nucleotidase. Extracellular adenosine interacts with P1 receptors and often opposes the effects of P2 receptor activation. The balance between extracellular ATP and adenosine in the blood and extracellular fluid is regulated chiefly by the activities of CD39 and CD73, which constitute the CD39-adenosinergic axis...
January 13, 2018: Purinergic Signalling
https://www.readbyqxmd.com/read/29326837/one-stage-approach-for-hybrid-atrial-fibrillation-treatment
#15
Vincent Umbrain, Christian Verborgh, Gian-Battista Chierchia, Carlo De Asmundis, Pedro Brugada, Mark La Meir
The one-stage approach for hybrid atrial fibrillation involves the simultaneous and close cooperation of different medical specialties. This review attempts to describe its challenging issues, exposing a plan to balance thrombotic risk and bleeding risk. It describes the combined surgical-electrophysiological procedure. Specific topics, involving hemodynamic, fluid and respiratory management during surgery are considered, and problems related to postoperative pain are surveyed.
December 2017: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/29324487/renal-replacement-therapy-in-critically-ill-patients-who-when-why-and-how
#16
Melanie Meersch, Alexander Zarbock
PURPOSE OF REVIEW: The increasing incidence of acute kidney injury has the immediate effect of a growing need for renal replacement therapy (RRT). Shedding light on the questions of who, when, why, and how RRT should be performed is difficult to accomplish because of ambiguous study results, poor quality evidence, and low standardization. RECENT FINDINGS: Critically ill patients are exposed to multiple factors known to deteriorate kidney function. Especially severe fluid overload is strongly associated with worse outcome and may be considered as a trigger for initiating RRT...
January 10, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29318981/magnesium-homeostasis-in-cattle-absorption-and-excretion
#17
Holger Martens, Sabine Leonhard-Marek, Monika Röntgen, Friederike Stumpff
Magnesium (Mg2+) is an essential mineral without known specific regulatory mechanisms. In ruminants, plasma Mg2+ concentration depends primarily on the balance between Mg2+ absorption and Mg2+ excretion. The primary site of Mg2+ absorption is the rumen, where Mg2+ is apically absorbed by both potential-dependent and potential-independent uptake mechanisms, reflecting involvement of ion channels and electroneutral transporters, respectively. Transport is energised in a secondary active manner by a basolateral Na+/Mg2+ exchanger...
January 10, 2018: Nutrition Research Reviews
https://www.readbyqxmd.com/read/29318729/validation-of-modelflow-estimates-of-cardiac-output-in-hemodialysis-patients
#18
Clare MacEwen, Sheera Sutherland, Jonathan Daly, Christopher Pugh, Lionel Tarassenko
Volume-clamp technology (e.g. Finometer) has become a popular method of collecting continuous, non-invasive, hemodynamic information during hemodialysis. There is minimal data validating the technique in this patient group. A gold standard cardiac output measurement can be obtained using ultrasound dilution in patients with arterio-venous fistulae. Continuous cardiac output was measured in 124 hemodialysis sessions in 27 patients using a volume-clamp device (Finometer PRO). Ultrasound dilution measurement was first taken at baseline (Transonic HD03), then used to calibrate the Finometer...
January 10, 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29316623/neurodegeneration-and-sensorimotor-deficits-in-the-mouse-model-of-traumatic-brain-injury
#19
Saurav Bhowmick, Veera D'Mello, Nizmi Ponery, P M Abdul-Muneer
Traumatic brain injury (TBI) can result in persistent sensorimotor and cognitive deficits, which occur through a cascade of deleterious pathophysiological events over time. In this study, we investigated the hypothesis that neurodegeneration caused by TBI leads to impairments in sensorimotor function. TBI induces the activation of the caspase-3 enzyme, which triggers cell apoptosis in an in vivo model of fluid percussion injury (FPI). We analyzed caspase-3 mediated apoptosis by terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining and poly (ADP-ribose) polymerase (PARP) and annexin V western blotting...
January 6, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29316334/geriatric-assessment-of-physical-and-cognitive-functioning-in-a-diverse-cohort-of-systemic-lupus-erythematosus-patients-a-pilot-study
#20
Laura Plantinga, Benjamin D Tift, Charmayne Dunlop-Thomas, S Sam Lim, C Barrett Bowling, Cristina Drenkard
OBJECTIVE: To use multi-domain functional assessment, commonly performed in geriatric patients but novel among SLE patients, to better understand functional impairment in SLE. METHODS: We recruited 60 adult participants [aged 20-39 (26.7%), 40-59 (50.0%), and ≥60 (23.3%); 80.0% black; 90.0% female] from an existing cohort of SLE patients. During in-person visits (10/16-4/17), we evaluated physical performance (range 0-4; higher scores = better performance); cognitive performance (five fluid cognition domains; adjusted t-scores); and self-reported measures including physical functioning (t-scores), activities of daily living (ADLs), falls, and life-space mobility...
January 5, 2018: Arthritis Care & Research
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