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Subclinical hypothyroidism children

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https://www.readbyqxmd.com/read/28049529/analysis-of-the-factors-affecting-the-evolution-over-time-of-subclinical-hypothyroidism-in-children
#1
EDITORIAL
Mariella Valenzise, Tommaso Aversa, Giuseppina Zirilli, Giuseppina Salzano, Domenico Corica, Simona Santucci, Filippo De Luca
Aim of this commentary is to report the most recent views about natural history of subclinical hypothyroidism (SH) according to the different etiologies. In children with idiopathic SH the natural evolution is often favourable, with a high percentage of cases reverting to euthyroidism or remaining SH even after a prolonged follow-up. By contrast, the risk of a significant deterioration of thyroid status is distinctly higher in the SH children with Hashimoto's thyroiditis (HT). This risk is even higher in the cases with both HT-related SH and chromosomal abnormalities, such as Turner or Down's syndrome...
January 3, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28008862/subclinical-hypothyroidism-in-children-may-lead-to-dyslipidemia-and-increased-carotid-intima-media-thickness
#2
Edip Ünal, Alper Akın, Ruken Yıldırım, Vasfiye Demir, İsmail Yıldız, Yusuf Kenan Haspolat
OBJECTIVE: Subclinical hypothyroidism (SH) is defined as elevated serum thyroid stimulating hormone (TSH) level with normal range of free thyroxine (fT4). There are very few studies in the literature reporting on the effect of SH on lipid metabolism and carotid intima-media thickness (CIMT) in children. METHODS: The study included 38 children diagnosed with SH and a control group comprising 38 healthy, euthyroid children. Subclinical hypothyroidism was diagnosed based on elevated TSH level (4...
December 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28008293/hormonal-and-echocardiographic-abnormalities-in-adult-patients-with-sickle-cell-anemia-in-bahrain
#3
Taysir S Garadah, Ahmed A Jaradat, Mohammed E Alalawi, Adla B Hassan
BACKGROUND: Adrenal, thyroid, and parathyroid gland hormonal changes are recognized in children with homozygous (HbSS) sickle-cell anemia (SCA), but are not clear in adult patients with SCA. AIM: To assess the metabolic and endocrine abnormalities in adult patients with SCA and evaluate left ventricular (LV) systolic and diastolic functions compared with patients with no SCA and further study the relationship between serum levels of cortisol, free thyroxine (T4), and testosterone with serum ferritin...
2016: Journal of Blood Medicine
https://www.readbyqxmd.com/read/27914141/unfavorable-course-of-subclinical-hypothyroidism-in-children-with-hashimoto-s-thyroiditis-compared-to-those-with-isolated-non-autoimmune-hyperthyrotropinemia
#4
Yun Jeong Lee, So Yoon Jung, Hae Woon Jung, So Youn Kim, Young Ah Lee, Seong Yong Lee, Choong Ho Shin, Sei Won Yang
Subclinical hypothyroidism (SCH) is a common problem in pediatric population, and the natural history of SCH varies depending on its etiology. Whether Hashimoto's thyroiditis (HT) negatively affects the natural course of SCH was investigated in pediatric patients without concomitant diseases. Predictors for levothyroxine medication were also evaluated. Medical records of 109 children with SCH (91 girls, 5?18 years) diagnosed between 2005 and 2014 were retrospectively reviewed. Patients were classified into HT (n = 37) and isolated non-autoimmune hyperthyrotropinemia (iso-NAHT, n = 72)...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27837466/thyroid-disruption-by-perfluorooctane-sulfonate-pfos-and-perfluorooctanoate-pfoa
#5
REVIEW
F Coperchini, O Awwad, M Rotondi, F Santini, M Imbriani, L Chiovato
BACKGROUND: Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) are two fluorinated compounds widely used in industry because of their useful chemical characteristics. They were identified as endocrine disruptors due to their ability to interfere with thyroid function. The resistance of PFOA and PFOS to environmental degradation, their bio-accumulation in food chains, and their long half-life raised concern in the scientific community, and several studies were performed with the aim to establish the real dangerousness of these compounds for the human health...
February 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27784959/endocrine-manifestations-in-celiac-disease
#6
REVIEW
Hugh James Freeman
Celiac disease (CD) is an autoimmune small intestinal mucosal disorder that often presents with diarrhea, malabsorption and weight loss. Often, one or more associated endocrine disorders may be associated with CD. For this review, methods involved an extensive review of published English-language materials. In children and adolescents, prospective studies have demonstrated a significant relationship to insulin-dependent or type 1 diabetes, whereas in adults, autoimmune forms of thyroid disease, particularly hypothyroidism, may commonly co-exist...
October 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27779276/the-debate-on-treating-subclinical-hypothyroidism
#7
Eng Loon Tng
Subclinical hypothyroidism (SCH) represents a mild or compensated form of primary hypothyroidism. The diagnosis of SCH is controversial, as its symptoms are non-specific and its biochemical diagnosis is arbitrary. The treatment of SCH was examined among non-pregnant adults, pregnant adults and children. In non-pregnant adults, treatment of SCH may prevent its progression to overt hypothyroidism, reduce the occurrence of coronary heart disease, and improve neuropsychiatric and musculoskeletal symptoms associated with hypothyroidism...
October 2016: Singapore Medical Journal
https://www.readbyqxmd.com/read/27611730/subclinical-hypothyroidism-in-danish-lean-and-obese-children-and-adolescents
#8
Maria Dahl, Johanne Dam Ohrt, Cilius Esmann Fonvig, Julie Tonsgaard Kloppenborg, Oluf Pedersen, Torben Hansen, Jens Christian Holm
OBJECTIVE: Thyroid abnormalities are common in obese children. The aim of the present study was to examine the prevalence of subclinical hypothyroidism (SH) and to determine how circulating thyroid hormone concentrations correlate with anthropometrics in Danish lean and obese children and adolescents. METHODS: We included 3,006 children and adolescents, aged 6-18 years, from the Registry of the Danish Childhood Obesity Biobank in this cross-sectional study. The overweight/obese group (n=1,796) consisted of study participants with a body mass index (BMI) standard deviation score (SDS) ≥1...
September 9, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27610347/subclinical-hypothyroidism-in-atopic-south-italian-children
#9
Marcella Pedullà, Vincenzo Fierro, Pierluigi Marzuillo, Ester Del Tufo, Anna Grandone, Laura Perrone, Emanuele Miraglia Del Giudice
AIM: To verify if subclinical hypothyroidism (SCH) could be associated to atopy in children. METHODS: Seven hundred and thirty-two Caucasian children from South Italy presenting symptoms of allergic disease were enrolled and submitted to atopy, obesity, chronic low grade inflammation, and SCH work up. RESULTS: Four hundred and forty-five out of 705 (63.12%) children affected by allergic disease were diagnosed as atopic and 260 (36.88%) as not atopic...
August 8, 2016: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/27552012/-hypovitaminosis-d-in-children-with-hashimoto%C3%A2-s-thyroiditis
#10
Ergün Sönmezgöz, Samet Ozer, Resul Yilmaz, Yalçın Önder, Ilknur Bütün, Serap Bilge
BACKGROUND: Vitamin D deficiency or insufficiency may play a role in the pathogenesis of certain autoimmune diseases. AIM: To measure vitamin D levels in children with Hashimoto’s thyroiditis (HT) (either with subclinical or marked hypothyroidism) and in healthy controls. MATERIAL AND METHODS: We included 68 children with HT aged 12 ± 4 years (39 females) from a pediatric outpatient clinic and 68 healthy children aged 10 ± 4 years (37 females)...
May 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27541075/five-year-prospective-evaluation-of-thyroid-function-test-evolution-in-children-with-hashimoto-s-thyroiditis-presenting-with-either-euthyroidism-or-subclinical-hypothyroidism
#11
Tommaso Aversa, Andrea Corrias, Mariacarolina Salerno, Daniele Tessaris, Raffaella Di Mase, Mariella Valenzise, Domenico Corica, Filippo De Luca, Malgorzata Wasniewska
BACKGROUND: Whether the course of thyroid function in Hashimoto's thyroiditis (HT) differs in children who present with either euthyroidism or subclinical hypothyroidism (SH) has been incompletely investigated. AIM: Using a five-year prospective evaluation of 234 children with HT and no prognostic risk factors, this study investigated whether the evolution of the thyroid status is influenced by the biochemical pattern at initial diagnosis. RESULTS: In the entire series, thyrotropin values significantly increased during follow-up, while free thyroxine values decreased and the proportion of children with a thyroid dysfunction increased from 27...
October 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27528870/evaluation-of-subclinical-hypothyroidism-in-children-and-adolescents-a-single-center-study
#12
Kamila Such, Aneta Gawlik, Aleksandra Dejner, Malgorzata Wasniewska, Agnieszka Zachurzok, Aleksandra Antosz, Tomasz Gawlik, Ewa Malecka-Tendera
The main purpose of our retrospective study was to evaluate the medical care of the patients with subclinical hypothyroidism (sHT) and to investigate the rationale for administering L-thyroxine (LT-4) to young sHT patients. Patients and Methods. Based on a retrospective review of the charts of 261 patients referred to the Endocrinology Outpatient Clinic between 2009 and 2014 with suspicion of sHT, 55 patients were enrolled for further analysis. Data collected was baseline age, anthropometric measurements, serum TSH, fT4, fT3, anti-thyroid autoantibodies, positive family history, absence/presence of clinical symptoms, length of follow-up, and data concerning LT-4 therapy (therapy: T1; no therapy: T0)...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27489467/celiac-disease-in-children-and-adolescents-with-hashimoto-thyroiditis
#13
Hale Tuhan, Sakine Işık, Ayhan Abacı, Erdem Şimşek, Ahmet Anık, Özden Anal, Ece Böber
AIM: The aim of this study was to evaluate clinical and laboratory findings and determine the prevalence of celiac disease (CD) in children with Hashimoto thyroiditis (HT). MATERIAL AND METHODS: The data of a total of 80 patients with positive anti-thyroid antibodies who were aged between 6 and 17.9 years were retrospectively studied. Age, gender, complaints at the time of presentation, family history of thyroid disorders, clinical and laboratory findings were recorded...
June 2016: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/27467896/pseudohypoparathyroidism-type-1a-subclinical-hypothyroidism-and-rapid-weight-gain-as-early-clinical-signs-a-clinical-review-of-10-cases
#14
Simon Kayemba-Kay's, Cedric Tripon, Anne Heron, Peter Hindmarsh
OBJECTIVE: To evaluate the clinical signs and symptoms that would help clinicians to consider pseudohypoparathyroidism (PHP) type 1A as a diagnosis in a child. METHODS: A retrospective review of the medical records of children diagnosed by erythrocyte Gsα activity and/or GNAS1 gene study and followed-up for PHP type 1A. Clinical and biochemical parameters along with epidemiological data were extracted and analyzed. Weight gain during infancy and early childhood was calculated as change in weight standard deviation score (SDS), using the French growth reference values...
1, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/27370068/iodine-status-and-prevalence-of-thyroid-disorders-after-introduction-of-mandatory-universal-salt-iodization-for-16-years-in-china-a-cross-sectional-study-in-10-cities
#15
Zhongyan Shan, Lulu Chen, Xiaolan Lian, Chao Liu, Bingyin Shi, Lixin Shi, Nanwei Tong, Shu Wang, Jianping Weng, Jiajun Zhao, Xiaochun Teng, Xiaohui Yu, Yaxin Lai, Weiwei Wang, Chenyan Li, Jinyuan Mao, Yongze Li, Chenling Fan, Weiping Teng
BACKGROUND: The goal of eliminating iodine deficiency worldwide was successfully achieved in China after the implementation of a mandatory universal salt iodization program for the last 16 years. Thus, China has been assessed as a country with more than adequate iodine levels. This survey aimed to investigate the current iodine status in China and the effects of an increased iodine intake on the spectrum and prevalence of thyroid disorders. METHODS: A total of 15,008 adult subjects from 10 cities in eastern and central China were investigated...
August 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27367720/thyroid-function-among-breastfed-children-with-chronically-excessive-iodine-intakes
#16
Inger Aakre, Tor A Strand, Trine Bjøro, Ingrid Norheim, Ingrid Barikmo, Susana Ares, Marta Duque Alcorta, Sigrun Henjum
Iodine excess may impair thyroid function and trigger adverse health consequences for children. This study aims to describe iodine status among breastfed infants with high iodine exposure in the Saharawi refugee camps Algeria, and further assess thyroid function and iodine status among the children three years later. In 2010, a cross-sectional study among 111 breastfed children aged 0-6 months was performed (baseline study). In 2013, a second cross-sectional study (follow-up study) was conducted among 289 children; 213 newly selected and 76 children retrieved from baseline...
June 28, 2016: Nutrients
https://www.readbyqxmd.com/read/27364598/subclinical-hypothyroidism-in-childhood-current-knowledge-and-open-issues
#17
REVIEW
Mariacarolina Salerno, Donatella Capalbo, Manuela Cerbone, Filippo De Luca
Subclinical hypothyroidism is defined as serum levels of TSH above the upper limit of the reference range, in the presence of normal concentrations of total T4 or free T4. This biochemical profile might be an indication of mild hypothyroidism, with a potential increased risk of metabolic abnormalities and cardiovascular disease recorded among adults. Whether subclinical hypothyroidism results in adverse health outcomes among children is a matter of debate and so management of this condition remains challenging...
December 2016: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/27228485/serum-polybrominated-diphenyl-ether-concentrations-and-thyroid-function-in-young-children
#18
Melanie H Jacobson, Dana B Barr, Michele Marcus, Andrew B Muir, Robert H Lyles, Penelope P Howards, Larissa Pardo, Lyndsey A Darrow
Thyroid hormones are essential for proper neurodevelopment in early life. There is evidence that exposure to polybrominated diphenyl ethers (PBDEs) affects thyroid function, but previous studies have been inconsistent, and no studies among children have been conducted in the United States where PBDE levels are particularly high. Serum levels of seven PBDE congeners and thyroid hormones and other thyroid parameters were measured in 80 children aged 1-5 years from the southeastern United States between 2011 and 2012...
August 2016: Environmental Research
https://www.readbyqxmd.com/read/27146071/evaluation-of-p-wave-dispersion-diastolic-function-and-atrial-electromechanical-conduction-in-pediatric-patients-with-subclinical-hypothyroidism
#19
Ahmet Irdem, Derya Aydın Sahin, Mehmet Kervancioglu, Osman Baspinar, Murat Sucu, Mehmet Keskin, Metin Kilinc
AIM: This study aimed to evaluate ventricular diastolic dysfunction, inter- and intraatrial conduction delay, and P-wave dispersion in pediatric patients with subclinical hypothyroidism. METHODS: The study comprised a total of 30 pediatric patients with subclinical hypothyroidism (SH) (mean age 7.8 ± 3.2 years) and 30 healthy children (mean age 8.4 ± 3.6 years) as the control group. A SH diagnosis was made in the event of increased serum thyroid-stimulating hormone (TSH) and decreased serum free triiodothyronine (T3 ) and free thyroxine (T4 ) concentrations...
September 2016: Echocardiography
https://www.readbyqxmd.com/read/27099936/duration-of-valproic-acid-monotherapy-correlates-with-subclinical-thyroid-dysfunction-in-children-with-epilepsy
#20
Violeta Ilić, Dragana Bogićević, Branislava Miljković, Maja Ješić, Marijana Kovačević, Milica Prostran, Sandra Vezmar Kovačević
To identify potential risk factors for the development of subclinical hypothyroidism following long-term valproic acid monotherapy in children with epilepsy. Serum levels of thyroid-stimulating hormone, free thyroxine, free triiodothyronine, thyreoglobulin antibodies, and thyroid peroxidase antibodies were determined in 41 patients and in 41 sex- and age-matched healthy children. Mean valproic acid treatment duration was 2.80±1.96 years. The valproic acid group had higher serum thyroid-stimulating hormone (p<0...
June 1, 2016: Epileptic Disorders: International Epilepsy Journal with Videotape
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