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Subclinical hypothyroidism children

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https://www.readbyqxmd.com/read/29769501/thyroid-status-in-children-with-transfusion-dependent-hb-e-%C3%AE-thalassaemia
#1
T Sharmin, A H Mollah, A A Morshed, M K Chowdhury
Despite improved haematological care, multi-endocrine dysfunction is a common complication in thalassemia. Iron overload is thought to be the most likely mechanism in thyroid dysfunction in these patients. Moreover, chronic tissue hypoxia might havedirect toxic effect on thyroid gland resulting in hypothyroidism. This study was designed to evaluate the thyroid status of children with Hb-E β-thalassemia. This cross sectional analytic study was conducted among thepatients with Hb-E β-thalassemia attending both in-patient & out-patient department of Paediatrics, Dhaka Medical College & Hospital, Dhaka, Bangladesh from April 2012 to March 2013...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29768692/prevalence-of-subclinical-hypothyroidism-in-obese-children-or-adolescents-and-association-between-thyroid-hormone-and-the-components-of-metabolic-syndrome
#2
Hye Young Jin
AIM: Subclinical hypothyroidism is defined as elevated thyroid-stimulating hormone (TSH) levels with the normal concentrations of thyroxine (T4) or free thyroxine (fT4), and its clinical significance is unclear. The purpose of this study is to investigate the prevalence of subclinical hypothyroidism in children and adolescents and determine the relationship between lipid profiles, insulin resistance and thyroid hormones. METHODS: A retrospective, cross-sectional study was performed using data from a subset of the KNHANES VI...
May 16, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29744522/-impact-of-thyroid-diseases-on-bone
#3
REVIEW
E Tsourdi, F Lademann, H Siggelkow
Thyroid hormones are key regulators of skeletal development in childhood and bone homeostasis in adulthood, and thyroid diseases have been associated with increased osteoporotic fractures. Hypothyroidism in children leads to an impaired skeletal maturation and mineralization, but an adequate and timely substitution with thyroid hormones stimulates bone growth. Conversely, hyperthyroidism at a young age accelerates skeletal development, but may also cause short stature because of a premature fusion of the growth plates...
May 9, 2018: Der Internist
https://www.readbyqxmd.com/read/29737233/excessive-iodine-intake-and-subclinical-hypothyroidism-in-children-and-adolescents-aged-6-19-years-results-of-the-sixth-korean-national-health-and-nutrition-examination-survey-knhanes-2013-2015
#4
Min Jae Kang, Il Tae Hwang, Hye Rim Chung
BACKGROUND: Iodine is an important element for the thyroid hormone production, and its deficiency or excessive intake is associated with various thyroid diseases. Little is known about the association between iodine status and thyroid function among children and adolescents living in iodine-rich areas, therefore, we analyzed this association using data from a nationwide survey. METHODS: From the Korea National Health and Nutrition Examination Surveys (KNHANES) VI (2013-2015) data, 1288 subjects (711 male) aged 6-19 years who underwent urinary iodine concentration (UIC) test and 1000 subjects (564 male) aged 10-19 years who underwent thyroid function test were included in this study...
May 8, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29609448/the-relationship-between-subclinical-hypothyroidism-and-serum-levels-of-uric-acid-and-creatinine-in-children-aged-2-14-years
#5
Saba Sayari, Ziba Molaei, Zohre Torabi
PURPOSE: Hypothyroidism is a clinical syndrome that can lead to elevated levels of serum creatinine and uric acid by causing impaired renal function. Although many studies have been carried out on the relationship between overt hypothyroidism and renal function, few studies have been conducted on subclinical hypothyroidism and renal function, especially in pediatric patients. For this reason, we studied this issue in children, so as to provide a background for more useful research and future education...
March 2018: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29553046/prevalence-and-related-factors-of-euthyroid-sick-syndrome-in-children-with-untreated-cancer-according-to-two-different-criteria
#6
Ali Duyu, Elvan Çağlar Çıtak, Erdem Ak, Serhan Kupeli, Begül Yağcı Küpeli, İbrahim Bayram, Gülay Sezgin, Gülçin Eskendari, Kerem Sezer
OBJECTIVE: In this study, we evaluated the frequency of euthyroid sick syndrome (ESS) among patients with childhood cancer and its association with the stage of disease, nutritional parameters and cytokines levels. METHODS: Eighty newly diagnosed children were included into study. ESS was diagnosed in two different ways:Criteria 1; fT3 was below the lower limit, fT4 was within the normal or low limits, TSH was in normal range and in criteria 2 all the levels were same as criteria 1 but moreover rT3 was performed and was higher than normal limits...
March 19, 2018: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29508221/the-effect-of-antiepileptic-drugs-on-thyroid-hormonal-function-valproic-acid-and-phenobarbital
#7
REVIEW
Olcay Güngör, Ahmet Kağan Özkaya, Fatih Temiz
The aim of this study was to evaluate the thyroid function alterations in a group of epileptic children taking antiepileptic drugs. The study included a total of 183 pediatric epilepsy patients, aged 15 months-16 years, comprising 114 patients treated with valproic acid, 69 patients treated with phenobarbital, and 151 age-matched healthy volunteers as the control group. Serum levels of thyroid hormones were measured before the beginning of the antiepileptic therapy and after 12 months of treatment. Thyroid-stimulating hormone levels were significantly higher in the 12th month of phenobarbital and valproic acid treatment...
March 5, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29469795/eritema-anular-eosinof%C3%A3-lico-en-un-adulto-eosinophilic-anular-erythema-in-an-adult
#8
Marta Aguado Lobo, Elena Sierra Gonzalo, José Jiménez-Reyes
Eosinophilic annular erythema (EAE) is an uncommon eosinophilic dermatosis. Clinically it is characterized by recurrent episodes of annular or figurative plaques. The histopathological study shows a perivascular inflammatory infiltrate in the superficial and deep dermis, composed of lymphocytes and eosinophils. It was originally described in children. We report an adult woman who presented with recurrent erythematous annular plaques on the trunk and extremities. A biopsy showed a mainly perivascular lymphocytic infiltrate with numerous eosinophils in the dermis...
October 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29463525/maternal-thyroid-function-and-child-educational-attainment-prospective-cohort-study
#9
Scott M Nelson, Caroline Haig, Alex McConnachie, Naveed Sattar, Susan M Ring, George D Smith, Debbie A Lawlor, Robert S Lindsay
OBJECTIVE: To determine if first trimester maternal thyroid dysfunction is a critical determinant of child scholastic performance and overall educational attainment. DESIGN: Prospective cohort study. SETTING: Avon Longitudinal Study of Parents and Children cohort in the UK. PARTICIPANTS: 4615 mother-child pairs with an available first trimester sample (median 10 weeks gestation, interquartile range 8-12). EXPOSURES: Free thyroxine, thyroid stimulating hormone, and thyroid peroxidase antibodies assessed as continuous measures and the seven clinical categories of maternal thyroid function...
February 20, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29454373/subclinical-hypothyroidism-in-children-is-it-always-subclinical
#10
R Gallizzi, C Crisafulli, T Aversa, G Salzano, F De Luca, M Valenzise, G Zirilli
Aim of this commentary is to report current knowledges on the main clinical and metabolic abnormalities which might be observed in children with longstanding and untreated subclinical hypothyroidism (SH) and to comment the most recent views about natural evolution of thyroid function in the cases with either idiopathic or Hashimoto's thyroiditis-related SH. On the basis of these preliminary remarks, the essential guidelines for an appropriate and tailored management of SH children are also proposed.
February 17, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29402856/dynamic-thiol-disulphide-homeostasis-in-children-and-adolescents-with-non-autoimmune-subclinical-hypothyroidism
#11
Seyit Ahmet Uçaktürk, Murat Alışık, Çağatay Uğur, Selin Elmaoğulları, Eda Mengen, Özcan Erel
OBJECTIVE: To evaluate the thiol/disulphide homeostasis in children with non-autoimmune subclinical hypothyroidism (SHT). SUBJECTS AND METHODS: Thiol/disulphide homeosta sis, involving native thiol (SH), disulphide (SS), and total thiol (SS + SH), was evaluated in 60 children and adolescents who were negative for thyroid auto-antibodies (anti-thyroid peroxidase, anti-thyroglobulin) and had a thyroid-stimulating hormone (TSH) value of > 5 mIU/L, and in 40 sex- and age-matched healthy control subjects who were negative for thyroid autoantibodies and had normal TSH levels...
2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29396214/hypothyroidism-during-pregnancy-and-its-association-to-perinatal-and-obstetric-morbidity-a-review
#12
María Martínez, Berta Soldevila, Anna Lucas, Inés Velasco, Lluis Vila, Manel Puig-Domingo
There is currently no consensus among the different scientific societies on screening for thyroid dysfunction in the first trimester of pregnancy. Indeed, diagnosis and treatment of subclinical hypothyroidism during pregnancy are controversial, as no cut-off value for thyrotropin (TSH) is universally accepted. TSH measurement may be influenced by different factors throughout pregnancy, but especially during the first trimester. The association between overt hypothyroidism during pregnancy and obstetric and perinatal complications is well established...
February 2018: Endocrinología, Diabetes y Nutrición
https://www.readbyqxmd.com/read/29369370/evaluation-of-qt-dispersion-and-tp-e-interval-in-children-with-subclinical-hypothyroidism
#13
Alper Akın, Edip Unal, Ruken Yıldırım, Mehmet Türe, Hasan Balık, Yusuf Kenan Haspolat
BACKGROUND: Studies on adults, have shown increased dispersion of QT and corrected QT (cQT), peak-to-end interval of the T wave (Tp-e), Tp-e/QT ratio and Tp-e/QTc ratio in subclinical hypothyroidism (SH), but there have been no paediatric studies MATERIALS AND METHODS: A total of 40 SH patients were compared with 40 healthy children in respect of serum thyroid stimulating hormone (TSH), serum free level of triiodothyronine (fT3) and free level of thyroxine (fT4). SH diagnosis was accepted as TSH above the laboratory accepted upper limit (> 4...
January 25, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29333819/hashimoto-s-disease-in-a-cohort-of-29-children-and-adolescents-epidemiology-clinical-course-and-comorbidities-in-the-short-and-long-term
#14
Eliot Gómez López, Ana P Nso-Roca, Mercedes Juste Ruiz, Ernesto Cortés Castell
Hashimoto's thyroiditis is the most common cause of goiter and hypothyroidism among children and adolescents. Its clinical manifestations and course vary. The objective of this study was to review the clinical and evolutionary characteristics of Hashimoto's disease in the pediatric population. Clinical, analytical, ultrasound, epidemiological, and evolutionary data of patients with autoimmune thyroiditis seen at Hospital Universitario San Juan de Alicante between January 2010 and January 2016 were analyzed...
February 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29325223/maternal-thyroid-hormone-insufficiency-during-pregnancy-and-risk-of-neurodevelopmental-disorders-in-offspring-a-systematic-review-and-meta-analysis
#15
William Thompson, Ginny Russell, Genevieve Baragwanath, Justin Matthews, Bijay Vaidya, Jo Thompson-Coon
BACKGROUND: In the last 2 decades, several studies have examined the association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children and shown conflicting results. AIM: This systematic review aimed to assess the evidence for an association between maternal thyroid hormone insufficiency during pregnancy and neurodevelopmental disorders in children. We also sought to assess whether levothyroxine treatment for maternal thyroid hormone insufficiency improves child neurodevelopment outcomes...
April 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29285443/cardiovascular-risk-factors-in-children-and-adolescents-with-subclinical-hypothyroidism
#16
Yogesh Yadav, Uma Kaimal Saikia, Dipti Sarma, Manoj Hazarika
Background: Subclinical hypothyroidism (SCH) is a commonly encountered entity in day-to-day clinical practice and has been associated with adverse cardiovascular risk profile in adults and children. Data on children and adolescents with SCH, from India, are limited. Materials and Methods: This study was a cross-sectional case-control study, conducted at a tertiary care center in Northeast India. Twenty-seven children and adolescents aged 11 ± 2.4 years with SCH and thyroid-stimulating hormone >7...
November 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29249510/bone-health-and-endocrine-comorbidities-in-pediatric-epilepsy
#17
Nancy A McNamara, Erin Marie Fedak Romanowski, David P Olson, Renee A Shellhaas
Antiseizure medications and dietary therapies have associated effects on the endocrine system. We provided an overview of the relationship between epilepsy treatment and bone health in children with epilepsy. Additionally, we discussed the effects of epilepsy treatment on other endocrine systems including thyroid function, growth, reproduction, and weight. The effect of epilepsy on bone health is multifactorial; there are direct and indirect effects of medication and dietary treatments as well as a decrease in physical activity, decreased sunlight exposure, decreased vitamin D levels, and additional comorbidities...
November 2017: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/29242418/subclinical-hypothyroidism-a-prospective-observational-study-from-southern-india
#18
Mathrubootham Sridhar, Shriraam Mahadevan, Latha Vishwanathan, Anbezhil Subbarayan
OBJECTIVE: To assess the natural history and progression of subclinical hypothyroidism and to study factors which help predict evolution of subclinical hypothyroidism into overt hypothyroidism. METHODS: Longitudinal study in 40 children (2-16 yrs) presenting with subclinical hypothyroidism in a tertiary care unit in Chennai, India. Patients showing evidence of overt hypothyroidism or thyroid stimulating hormone ≥ 15 mIU/mL during follow-up were started on thyroxine...
December 14, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29193939/-prevalence-of-subclinical-hypothyroidism-in-pediatric-patients-with-drug-resistant-epilepsy
#19
Adriana Lorena Aparicio-Claure, Jesús Darío Rayo-Mares, Elisa Nishimura-Meguro, Julia Rocío Herrera-Márquez, Juan Pablo Muñoz-Montúfar, Juan Carlos Núñez-Enríquez
BACKGROUND: In several studies it has been reported a high prevalence of subclinical hypothyroidism in children with epilepsy secondary to the use of monotherapy with valproic acid, carbamazepine and phenytoin. The aim of this article is to determine the prevalence of subclinical hypothyroidism in children with drug-resistant epilepsy treated at the Pediatric Neurology Service of the Hospital de Pediatría, Centro Médico Nacional Siglo XXI in Mexico City. METHODS: We conducted a descriptive cross-sectional study...
September 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/29127763/thyroid-evaluation-of-children-and-adolescents-with-williams-syndrome-in-zhejiang-province
#20
Wei-Jun Chen, Chai Ji, Dan Yao, Zheng-Yan Zhao
BACKGROUND: The objective of the study was to describe the prevalence of abnormal thyroid function and volume in children and adolescents with Williams syndrome (WS) in Zhejiang Province, China. METHODS: Thyroid function, including thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and thyroid antibodies (thyroid peroxidase and thyroglobulin) were measured in 83 patients with WS, aged 0.2-16.5 years. Twenty-three patients were followed for an average of 1...
November 27, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
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